Lab on a Chip

Article	Citations
Point-of-care testing detection methods for COVID-19	176
Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature	171
An outlook on microfluidics: the promise and the challenge	163
Conventional and emerging strategies for the fabrication and functionalization of PDMS-based microfluidic devices	137
High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows	131
Single-cell microfluidic impedance cytometry: from raw signals to cell phenotypes using data analytics	121
A microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay for rapid COVID-19 detection	115
Engineering neurovascular organoids with 3D printed microfluidic chips	92
Accelerating innovation and commercialization through standardization of microfluidic-based medical devices	86
Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures	85
Recent innovations in cost-effective polymer and paper hybrid microfluidic devices	78
Anin vitrovascularized micro-tumor model of human colorectal cancer recapitulatesin vivoresponses to standard-of-care therapy	75
HiPSC-derived multi-organoids-on-chip system for safety assessment of antidepressant drugs	74
Controllable fusion of human brain organoids using acoustofluidics	67
Standardisation needs for organ on chip devices	65
Simulating drug concentrations in PDMS microfluidic organ chips	65
Understanding and improving FDM 3D printing to fabricate high-resolution and optically transparent microfluidic devices	62
Microfluidic-based capture and release of cancer-derived exosomes via peptide–nanowire hybrid interface	62
Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?	62
Autonomous lab-on-paper for multiplexed, CRISPR-based diagnostics of SARS-CoV-2	61
Multiphysics microfluidics for cell manipulation and separation: a review	59
Microfluidic technologies for nanoparticle formation	59
Machine learning for microfluidic design and control	58
A thread/fabric-based band as a flexible and wearable microfluidic device for sweat sensing and monitoring	58
Neural network-enhanced real-time impedance flow cytometry for single-cell intrinsic characterization	57

Developing an advanced gut on chip model enabling the study of epithelial cell/fibroblast interactions	56
Nanoparticle protein corona: from structure and function to therapeutic targeting	55
A high-throughput multiplexed microfluidic device for COVID-19 serology assays	55
Engineering a sustainable future for point-of-care diagnostics and single-use microfluidic devices	55
A flux-adaptable pump-free microfluidics-based self-contained platform for multiplex cancer biomarker detection	55
Printed microfluidic sweat sensing platform for cortisol and glucose detection	54
3D printed microfluidics: advances in strategies, integration, and applications	54
Materials and methods for droplet microfluidic device fabrication	54
The acoustic droplet printing of functional tumor microenvironments	52
Thin-film-transistor digital microfluidics for high value in vitro diagnostics at the point of need	52
Speeding up reconstruction of 3D tomograms in holographic flow cytometry via deep learning	51
Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant read-outs for tissue permeability and vascular structure	51
Bubbles in microfluidics: an all-purpose tool for micromanipulation	49
Tubular human brain organoids to model microglia-mediated neuroinflammation	49
Membrane integration into PDMS-free microfluidic platforms for organ-on-chip and analytical chemistry applications	49
“One-to-three” droplet generation in digital microfluidics for parallel chemiluminescence immunoassays	49
Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out	48
Extracellular vesicle mediated feto-maternal HMGB1 signaling induces preterm birth	48
Inertial microfluidics: current status, challenges, and future opportunities	47
Biomedical optical fibers	46
Liquid marble-based digital microfluidics – fundamentals and applications	46
Self-powered droplet manipulation system for microfluidics based on triboelectric nanogenerator harvesting rotary energy	46
High throughput transepithelial electrical resistance (TEER) measurements on perfused membrane-free epithelia	45
Label-free microfluidic cell sorting and detection for rapid blood analysis	45
Fiber optic hydrogen sensor based on a Fabry–Perot interferometer with a fiber Bragg grating and a nanofilm	45
Liver organ-on-chip models for toxicity studies and risk assessment	44
Plasmonic nanobowtiefluidic device for sensitive detection of glioma extracellular vesicles by Raman spectrometry	44
Microneedle-based transdermal detection and sensing devices	44
Microliter ultrafast centrifuge platform for size-based particle and cell separation and extraction using novel omnidirectional spiral surface acoustic waves	42
Advances in microfluidic extracellular vesicle analysis for cancer diagnostics	42
Point-of-care diagnostics: recent developments in a pandemic age	42
Interfacing cells with organic transistors: a review ofin vitroandin vivoapplications	41
Tailored point-of-care biosensors for liquid biopsy in the field of oncology	41
Intelligent acoustofluidics enabled mini-bioreactors for human brain organoids	41
Microscopic artificial cilia – a review	41
Recent advances in the microfluidic production of functional microcapsules by multiple-emulsion templating	40
Simple and fast isolation of circulating exosomes with a chitosan modified shuttle flow microchip for breast cancer diagnosis	40
Biologically inspired micro-robotic swimmers remotely controlled by ultrasound waves	39
Nonlinear microfluidics: device physics, functions, and applications	39
Lateral flow assays for hormone detection	39
Unconventional acoustic approaches for localized and designed micromanipulation	39
User-friendly image-activated microfluidic cell sorting technique using an optimized, fast deep learning algorithm	38
Microdissected “cuboids” for microfluidic drug testing of intact tissues	38
Tumor-on-a-chip platforms to study cancer–immune system crosstalk in the era of immunotherapy	38
Direct isolation of circulating extracellular vesicles from blood for vascular risk profiling in type 2 diabetes mellitus	37
Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy	37
A multilayered blood vessel/tumor tissue chip to investigate T cell infiltration into solid tumor tissues	37
Interstitial flow enhances the formation, connectivity, and function of 3D brain microvascular networks generated within a microfluidic device	37
Retinal organoids on-a-chip: a micro-millifluidic bioreactor for long-term organoid maintenance	37
A portable, 3D printed, microfluidic device for multiplexed, real time, molecular detection of the porcine epidemic diarrhea virus, transmissible gastroenteritis virus, and porcine deltacoronavirus at	37

Recent microfluidic advances in submicron to nanoparticle manipulation and separation	36
A 3D human adipose tissue model within a microfluidic device	36
Ultraviolet-induced in situ gold nanoparticles for point-of-care testing of infectious diseases in loop-mediated isothermal amplification	36
Vasculature-on-a-chip platform with innate immunity enables identification of angiopoietin-1 derived peptide as a therapeutic for SARS-CoV-2 induced inflammation	36
Simultaneous single-cell phenotype analysis of hepatocellular carcinoma CTCs using a SERS-aptamer based microfluidic chip	36
Cascaded filter deterministic lateral displacement microchips for isolation and molecular analysis of circulating tumor cells and fusion cells	36
Rapid and precise tumor cell separation using the combination of size-dependent inertial and size-independent magnetic methods	35
Gear-shaped micromixer for synthesis of silica particles utilizing inertio-elastic flow instability	35
Establishment of a human three-dimensional chip-based chondro-synovial coculture joint model for reciprocal cross talk studies in arthritis research	35
Construction of a high fidelity epidermis-on-a-chip for scalable in vitro irritation evaluation	35
Deciphering impedance cytometry signals with neural networks	35
Submicron-precision particle characterization in microfluidic impedance cytometry with double differential electrodes	34
Wearable chem-biosensing devices: from basic research to commercial market	34
Automated biophysical classification of apoptotic pancreatic cancer cell subpopulations by using machine learning approaches with impedance cytometry	34
Fabrication of tunable, high-molecular-weight polymeric nanoparticles via ultrafast acoustofluidic micromixing	34
Sensing morphogenesis of bone cells under microfluidic shear stress by holographic microscopy and automatic aberration compensation with deep learning	34
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips	34
A microfluidic cathodic photoelectrochemical biosensor chip for the targeted detection of cytokeratin 19 fragments 21-1	34
Review of microfluidic approaches for fabricating intelligent fiber devices: importance of shape characteristics	33
Recent advances in lab-on-paper diagnostic devices using blood samples	33
A novel human arterial wall-on-a-chip to study endothelial inflammation and vascular smooth muscle cell migration in early atherosclerosis	33
Investigations on T cell transmigration in a human skin-on-chip (SoC) model	33
Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers	33
Fabrication of monodisperse alginate microgel beads by microfluidic picoinjection: a chelate free approach	33
A review on microrobots driven by optical and magnetic fields	33
An electricity- and instrument-free infectious disease sensor based on a 3D origami paper-based analytical device	33
Real-time isothermal DNA amplification monitoring in picoliter volumes using an optical fiber sensor	33
A 3-dimensional microfluidic platform for modeling human extravillous trophoblast invasion and toxicological screening	32
A sample-to-answer, quantitative real-time PCR system with low-cost, gravity-driven microfluidic cartridge for rapid detection of SARS-CoV-2, influenza A/B, and human papillomavirus 16/18	32
Review: tomographic imaging flow cytometry	32
Microfluidic platforms for extracellular vesicle isolation, analysis and therapy in cancer	32
Enzyme-based digital bioassay technology – key strategies and future perspectives	32
An integrated microfluidic system for early detection of sepsis-inducing bacteria	32
In vitro assay for single-cell characterization of impaired deformability in red blood cells under recurrent episodes of hypoxia	32
A digital protein microarray for COVID-19 cytokine storm monitoring	32
A robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology	32
Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies	32
Recent advances in integrated solid-state nanopore sensors	31
Tuning particle inertial separation in sinusoidal channels by embedding periodic obstacle microstructures	31
Microfluidic point-of-care device for detection of early strains and B.1.1.7 variant of SARS-CoV-2 virus	31
A fully transparent, flexible PEDOT:PSS–ITO–Ag–ITO based microelectrode array for ECoG recording	31
Microfluidic channel integrated with a lattice lightsheet microscopic system for continuous cell imaging	31
Recent progress on wearable point-of-care devices for ocular systems	30
FertDish: microfluidic sperm selection-in-a-dish for intracytoplasmic sperm injection	30
A simple and reversible glass–glass bonding method to construct a microfluidic device and its application for cell recovery	30
A rapid nucleic acid concentration measurement system with large field of view for a droplet digital PCR microfluidic chip	30
Rapid nitrate determination with a portable lab-on-chip device based on double microstructured assisted reactors	29
A graphene oxide coated tapered microfiber acting as a super-sensor for rapid detection of SARS-CoV-2	29
Cancer drug screening with an on-chip multi-drug dispenser in digital microfluidics	29
Immuno-biosensor on a chip: a self-powered microfluidic-based electrochemical biosensing platform for point-of-care quantification of proteins	29
Microfluidic-based in vitro thrombosis model for studying microplastics toxicity	29
Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion	29
Recent methods of droplet microfluidics and their applications in spheroids and organoids	29
Bacterial classification and antibiotic susceptibility testing on an integrated microfluidic platform	29
Application of a gut–liver-on-a-chip device and mechanistic modelling to the quantitative in vitro pharmacokinetic study of mycophenolate mofetil	29
3-D swimming microdrone powered by acoustic bubbles	29
Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models	28
Measuring barrier function in organ-on-chips with cleanroom-free integration of multiplexable electrodes	28
Slip formation of a high-density droplet array for nucleic acid quantification by digital LAMP with a random-access system	28
Emerging point-of-care technologies for anemia detection	28
Engineering a deformation-free plastic spiral inertial microfluidic system for CHO cell clarification in biomanufacturing	28
Oxygen control: the often overlooked but essential piece to create betterin vitrosystems	28
Postoperative evaluation of tumours based on label-free acoustic separation of circulating tumour cells by microstreaming	28
Three-dimensional imaging on a chip using optofluidics light-sheet fluorescence microscopy	28
Deep imaging flow cytometry	27
Predicting the fluid behavior of random microfluidic mixers using convolutional neural networks	27
Assessing red blood cell deformability from microscopy images using deep learning	27
Zigzag microchannel for rigid inertial separation and enrichment (Z-RISE) of cells and particles	27
Digital microfluidics for biological analysis and applications	27
Acoustic valves in microfluidic channels for droplet manipulation	27
Inertial focusing of circulating tumor cells in whole blood at high flow rates using the microfluidic CTCKey™ device for CTC enrichment	27
Isolation and recovery of extracellular vesicles using optically-induced dielectrophoresis on an integrated microfluidic platform	27
Tunnel dielectrophoresis for ultra-high precision size-based cell separation	26
Microfluidic formation of crystal-like structures	26
Technologies for measuring red blood cell deformability	26
Multi-oscillation microrheology via acoustic force spectroscopy enables frequency-dependent measurements on endothelial cells at high-throughput	26
On-chip rapid drug screening of leukemia cells by acoustic streaming	26
Microfluidic droplet-based functional materials for cell manipulation	26
Intestinal explant barrier chip: long-term intestinal absorption screening in a novel microphysiological system using tissue explants	26
Integration of segmented microflow chemistry and online HPLC/MS analysis on a microfluidic chip system enabling enantioselective analyses at the nanoliter scale	26

Versatile acoustic manipulation of micro-objects using mode-switchable oscillating bubbles: transportation, trapping, rotation, and revolution	26
Machine learning assisted fast prediction of inertial lift in microchannels	26
Flowmetering for microfluidics	26
Closed-loop feedback control of microfluidic cell manipulation via deep-learning integrated sensor networks	25
Cell-sorting centrifugal microfluidic chip with a flow rectifier	25
Microfluidic model with air-walls reveals fibroblasts and keratinocytes modulate melanoma cell phenotype, migration, and metabolism	25
Disposable photonics for cost-effective clinical bioassays: application to COVID-19 antibody testing	25
A microfluidic chip with a serpentine channel enabling high-throughput cell separation using surface acoustic waves	25
On the acoustically induced fluid flow in particle separation systems employing standing surface acoustic waves – Part I	25
Size-tuneable isolation of cancer cells using stretchable inertial microfluidics	25
Recent advances in microfluidic devices for single-cell cultivation: methods and applications	25
High-throughput and label-free enrichment of malignant tumor cells and clusters from pleural and peritoneal effusions using inertial microfluidics	25
Automated sample-to-answer centrifugal microfluidic system for rapid molecular diagnostics of SARS-CoV-2	25
Optimized design of obstacle sequences for microfluidic mixing in an inertial regime	25
Bridging the academic–industrial gap: application of an oxygen and pH sensor-integrated lab-on-a-chip in nanotoxicology	24
Non-small cell lung carcinoma spheroid models in agarose microwells for drug response studies	24
Human neuromuscular junction on micro-structured microfluidic devices implemented with a custom micro electrode array (MEA)	24
Advances in droplet digital polymerase chain reaction on microfluidic chips	24
High-throughput digital pathology via a handheld, multiplexed, and AI-powered ptychographic whole slide scanner	24
A continuous flow PCR array microfluidic chip applied for simultaneous amplification of target genes of periodontal pathogens	24
A fully integrated biomimetic microfluidic device for evaluation of sperm response to thermotaxis and chemotaxis	24
A microfluidic device enabling deterministic single cell trapping and release	24
Portable sample processing for molecular assays: application to Zika virus diagnostics	24
Engineering inclined orientations of piezoelectric films for integrated acoustofluidics and lab-on-a-chip operated in liquid environments	24
Blood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research	24
Hotspots of root-exuded amino acids are created within a rhizosphere-on-a-chip	24
Stromal cell identity modulates vascular morphogenesis in a microvasculature-on-a-chip platform	24
A sequentially bioconjugated optofluidic laser for wash-out-free and rapid biomolecular detection	24
Microfluidic single-cell transcriptomics: moving towards multimodal and spatiotemporal omics	23
Microfluidic quantum sensing platform for lab-on-a-chip applications	23
Automated fluorescence quantification of extracellular vesicles collected from blood plasma using dielectrophoresis	23
A microphysiological early metastatic niche on a chip reveals how heterotypic cell interactions and inhibition of integrin subunit β3 impact breast cancer cell extravasation	23
Surfactant-laden droplet size prediction in a flow-focusing microchannel: a data-driven approach	23
High performance inkjet printed embedded electrochemical sensors for monitoring hypoxia in a gut bilayer microfluidic chip	23
Microfluidic technologies for immunotherapy studies on solid tumours	23
Deep learning detector for high precision monitoring of cell encapsulation statistics in microfluidic droplets	23
Spatial trans-epithelial electrical resistance (S-TEER) integrated in organs-on-chips	23
Label-free inertial-ferrohydrodynamic cell separation with high throughput and resolution	23
Multi-parametric functional imaging of cell cultures and tissues with a CMOS microelectrode array	23
The vascular niche in next generation microphysiological systems	23
High-throughput injection molded microfluidic device for single-cell analysis of spatiotemporal dynamics	23
Rapid isolation of circulating cancer associated fibroblasts by acoustic microstreaming for assessing metastatic propensity of breast cancer patients	23
A microfluidic cartridge for fast and accurate diagnosis of Mycobacterium tuberculosis infections on standard laboratory equipment	23
Multiplex amplification of target genes of periodontal pathogens in continuous flow PCR microfluidic chip	22
Will the next generation of chemical plants be in miniaturized flow reactors?	22
Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip	22
Dosage-controlled intracellular delivery mediated by acoustofluidics for lab on a chip applications	22
Development of a human neuromuscular tissue-on-a-chip model on a 24-well-plate-format compartmentalized microfluidic device	22
An antibiotic concentration gradient microfluidic device integrating surface-enhanced Raman spectroscopy for multiplex antimicrobial susceptibility testing	22
Parallel multistep digital analysis SlipChip demonstrated with the quantification of nucleic acid by digital LAMP-CRISPR	22
Development and future of droplet microfluidics	22
Point-of-care microchip electrophoresis for integrated anemia and hemoglobin variant testing	22
Emulating the chondrocyte microenvironment using multi-directional mechanical stimulation in a cartilage-on-chip	22
Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy	22
Focused surface acoustic wave locally removes cells from culture surface	22
Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems	22
Microfluidics for antibiotic susceptibility testing	22
Small intestinal sampling capsule for inflammatory bowel disease type detection and management	22
Practical microcircuits for handheld acoustofluidics	22
Generation of flow and droplets with an ultra-long-range linear concentration gradient	22
An “occlusive thrombosis-on-a-chip” microfluidic device for investigating the effect of anti-thrombotic drugs	22
Self-aligned sequential lateral field non-uniformities over channel depth for high throughput dielectrophoretic cell deflection	22
A polymer index-matched to water enables diverse applications in fluorescence microscopy	22
Lab-in-a-pencil graphite: A 3D-printed microfluidic sensing platform for real-time measurement of antipsychotic clozapine level	22
A plantar wearable pressure sensor based on hybrid lead zirconate-titanate/microfibrillated cellulose piezoelectric composite films for human health monitoring	21
A critical review of microfluidic systems for CRISPR assays	21
An epidermal wearable microfluidic patch for simultaneous sampling, storage, and analysis of biofluids with counterion monitoring	21
3D-printed capillaric ELISA-on-a-chip with aliquoting	21
Efficient and gentle delivery of molecules into cells with different elasticity via Progressive Mechanoporation	21
A microfluidic device and instrument prototypes for the detection of Escherichia coli in water samples using a phage-based bioluminescence assay	21
Recent advances in gold electrode fabrication for low-resource setting biosensing	21
Biohybrid sensor for odor detection	21
Fluidic circuit board with modular sensor and valves enables stand-alone, tubeless microfluidic flow control in organs-on-chips	21
Quantitative particle agglutination assay for point-of-care testing using mobile holographic imaging and deep learning	21
Integrated microfluidic platform with electrohydrodynamic focusing and a carbon-nanotube-based field-effect transistor immunosensor for continuous, selective, and label-free quantification of bacteria	21
Recent advances in microfluidics-based cell migration research	21
Programmable motion control and trajectory manipulation of microparticles through tri-directional symmetrical acoustic tweezers	21
IL-2 secretion-based sorting of single T cells using high-throughput microfluidic on-cell cytokine capture	20
A method of sequential liquid dispensing for the multiplexed genetic diagnosis of viral infections in a microfluidic device	20
Microfluidic recapitulation of circulating tumor cell–neutrophil clusters via double spiral channel-induced deterministic encapsulation	20
Lateral flow device for water fecal pollution assessment: from troubleshooting of its microfluidics using bioluminescence to colorimetric monitoring of generic Escherichia coli	20
Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response	20
Size and density measurements of single sickle red blood cells using microfluidic magnetic levitation	20
Bio-inspired fractal textile device for rapid sweat collection and monitoring	20
Extraction of small extracellular vesicles by label-free and biocompatible on-chip magnetic separation	20
Flexural wave-based soft attractor walls for trapping microparticles and cells	20
Scaffold-free generation of heterotypic cell spheroids using acoustofluidics	20
Microfluidic solutions for biofluids handling in on-skin wearable systems	20
Go with the flow: modeling unique biological flows in engineeredin vitroplatforms	20
Monitoring the effects of chemical stimuli on live cells with metasurface-enhanced infrared reflection spectroscopy	20
Label-free detection and enumeration of rare circulating tumor cells by bright-field image cytometry and multi-frame image correlation analysis	20
3D micromixer for nanoliposome synthesis: a promising advance in high mass productivity	20
On-chip perivascularnichesupporting stemness of patient-derived glioma cells in a serum-free, flowable culture	20
Sheathless and high-throughput elasto-inertial bacterial sorting for enhancing molecular diagnosis of bloodstream infection	20
Simplifying the complex: accessible microfluidic solutions for contemporary processes within in vitro diagnostics	20