Lab on a Chip

Article	Citations
Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature	153
Point-of-care testing detection methods for COVID-19	148
An outlook on microfluidics: the promise and the challenge	117
Conventional and emerging strategies for the fabrication and functionalization of PDMS-based microfluidic devices	114
Single-cell microfluidic impedance cytometry: from raw signals to cell phenotypes using data analytics	109
High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows	106
A microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay for rapid COVID-19 detection	102
Engineering neurovascular organoids with 3D printed microfluidic chips	71
Accelerating innovation and commercialization through standardization of microfluidic-based medical devices	70
Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures	67
Recent innovations in cost-effective polymer and paper hybrid microfluidic devices	62
Microfluidic-based capture and release of cancer-derived exosomes via peptide–nanowire hybrid interface	57
HiPSC-derived multi-organoids-on-chip system for safety assessment of antidepressant drugs	57
Anin vitrovascularized micro-tumor model of human colorectal cancer recapitulatesin vivoresponses to standard-of-care therapy	56
Controllable fusion of human brain organoids using acoustofluidics	55
Understanding and improving FDM 3D printing to fabricate high-resolution and optically transparent microfluidic devices	54
A flux-adaptable pump-free microfluidics-based self-contained platform for multiplex cancer biomarker detection	52
A high-throughput multiplexed microfluidic device for COVID-19 serology assays	52
Autonomous lab-on-paper for multiplexed, CRISPR-based diagnostics of SARS-CoV-2	52
Simulating drug concentrations in PDMS microfluidic organ chips	52
Standardisation needs for organ on chip devices	51
Developing an advanced gut on chip model enabling the study of epithelial cell/fibroblast interactions	50
Neural network-enhanced real-time impedance flow cytometry for single-cell intrinsic characterization	48
Multiphysics microfluidics for cell manipulation and separation: a review	48
The acoustic droplet printing of functional tumor microenvironments	47

A thread/fabric-based band as a flexible and wearable microfluidic device for sweat sensing and monitoring	47
Microfluidic technologies for nanoparticle formation	46
Engineering a sustainable future for point-of-care diagnostics and single-use microfluidic devices	45
Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out	45
Machine learning for microfluidic design and control	44
Liquid marble-based digital microfluidics – fundamentals and applications	42
Tubular human brain organoids to model microglia-mediated neuroinflammation	42
Extracellular vesicle mediated feto-maternal HMGB1 signaling induces preterm birth	41
Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?	41
Bubbles in microfluidics: an all-purpose tool for micromanipulation	40
Printed microfluidic sweat sensing platform for cortisol and glucose detection	40
Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant read-outs for tissue permeability and vascular structure	40
Thin-film-transistor digital microfluidics for high value in vitro diagnostics at the point of need	39
Membrane integration into PDMS-free microfluidic platforms for organ-on-chip and analytical chemistry applications	39
Self-powered droplet manipulation system for microfluidics based on triboelectric nanogenerator harvesting rotary energy	39
Speeding up reconstruction of 3D tomograms in holographic flow cytometry via deep learning	39
Advances in microfluidic extracellular vesicle analysis for cancer diagnostics	38
“One-to-three” droplet generation in digital microfluidics for parallel chemiluminescence immunoassays	37
Biomedical optical fibers	37
Plasmonic nanobowtiefluidic device for sensitive detection of glioma extracellular vesicles by Raman spectrometry	36
Liver organ-on-chip models for toxicity studies and risk assessment	36
Interfacing cells with organic transistors: a review ofin vitroandin vivoapplications	35
Unconventional acoustic approaches for localized and designed micromanipulation	35
Fiber optic hydrogen sensor based on a Fabry–Perot interferometer with a fiber Bragg grating and a nanofilm	35
Inertial microfluidics: current status, challenges, and future opportunities	35
User-friendly image-activated microfluidic cell sorting technique using an optimized, fast deep learning algorithm	35
Materials and methods for droplet microfluidic device fabrication	34
High throughput transepithelial electrical resistance (TEER) measurements on perfused membrane-free epithelia	34
Direct isolation of circulating extracellular vesicles from blood for vascular risk profiling in type 2 diabetes mellitus	33
Simple and fast isolation of circulating exosomes with a chitosan modified shuttle flow microchip for breast cancer diagnosis	33
Tumor-on-a-chip platforms to study cancer–immune system crosstalk in the era of immunotherapy	33
Intelligent acoustofluidics enabled mini-bioreactors for human brain organoids	33
Nonlinear microfluidics: device physics, functions, and applications	33
Biologically inspired micro-robotic swimmers remotely controlled by ultrasound waves	33
A 3D human adipose tissue model within a microfluidic device	33
Microliter ultrafast centrifuge platform for size-based particle and cell separation and extraction using novel omnidirectional spiral surface acoustic waves	32
A multilayered blood vessel/tumor tissue chip to investigate T cell infiltration into solid tumor tissues	32
Deciphering impedance cytometry signals with neural networks	32
Microdissected “cuboids” for microfluidic drug testing of intact tissues	32
Cascaded filter deterministic lateral displacement microchips for isolation and molecular analysis of circulating tumor cells and fusion cells	32
Point-of-care diagnostics: recent developments in a pandemic age	32
Retinal organoids on-a-chip: a micro-millifluidic bioreactor for long-term organoid maintenance	31
Review: tomographic imaging flow cytometry	31
Review of microfluidic approaches for fabricating intelligent fiber devices: importance of shape characteristics	31
Ultraviolet-induced in situ gold nanoparticles for point-of-care testing of infectious diseases in loop-mediated isothermal amplification	31
Submicron-precision particle characterization in microfluidic impedance cytometry with double differential electrodes	31
Nanoparticle protein corona: from structure and function to therapeutic targeting	31
Label-free microfluidic cell sorting and detection for rapid blood analysis	31
Tailored point-of-care biosensors for liquid biopsy in the field of oncology	30
Microscopic artificial cilia – a review	30

A digital protein microarray for COVID-19 cytokine storm monitoring	30
Gear-shaped micromixer for synthesis of silica particles utilizing inertio-elastic flow instability	29
Wearable chem-biosensing devices: from basic research to commercial market	29
A microfluidic cathodic photoelectrochemical biosensor chip for the targeted detection of cytokeratin 19 fragments 21-1	29
Microfluidic platforms for extracellular vesicle isolation, analysis and therapy in cancer	29
3D printed microfluidics: advances in strategies, integration, and applications	29
Rapid and precise tumor cell separation using the combination of size-dependent inertial and size-independent magnetic methods	29
Simultaneous single-cell phenotype analysis of hepatocellular carcinoma CTCs using a SERS-aptamer based microfluidic chip	29
A portable, 3D printed, microfluidic device for multiplexed, real time, molecular detection of the porcine epidemic diarrhea virus, transmissible gastroenteritis virus, and porcine deltacoronavirus at	29
Recent advances in the microfluidic production of functional microcapsules by multiple-emulsion templating	29
Lateral flow assays for hormone detection	29
An integrated microfluidic system for early detection of sepsis-inducing bacteria	29
FertDish: microfluidic sperm selection-in-a-dish for intracytoplasmic sperm injection	29
Construction of a high fidelity epidermis-on-a-chip for scalable in vitro irritation evaluation	28
In vitro assay for single-cell characterization of impaired deformability in red blood cells under recurrent episodes of hypoxia	28
Microfluidic channel integrated with a lattice lightsheet microscopic system for continuous cell imaging	28
Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers	28
Real-time isothermal DNA amplification monitoring in picoliter volumes using an optical fiber sensor	28
Sensing morphogenesis of bone cells under microfluidic shear stress by holographic microscopy and automatic aberration compensation with deep learning	28
Recent advances in lab-on-paper diagnostic devices using blood samples	28
Vasculature-on-a-chip platform with innate immunity enables identification of angiopoietin-1 derived peptide as a therapeutic for SARS-CoV-2 induced inflammation	28
Investigations on T cell transmigration in a human skin-on-chip (SoC) model	27
Fabrication of tunable, high-molecular-weight polymeric nanoparticles via ultrafast acoustofluidic micromixing	27
A 3-dimensional microfluidic platform for modeling human extravillous trophoblast invasion and toxicological screening	27
A fully transparent, flexible PEDOT:PSS–ITO–Ag–ITO based microelectrode array for ECoG recording	27
An electricity- and instrument-free infectious disease sensor based on a 3D origami paper-based analytical device	27
Recent progress on wearable point-of-care devices for ocular systems	27
Interstitial flow enhances the formation, connectivity, and function of 3D brain microvascular networks generated within a microfluidic device	27
A novel human arterial wall-on-a-chip to study endothelial inflammation and vascular smooth muscle cell migration in early atherosclerosis	27
3-D swimming microdrone powered by acoustic bubbles	26
Slip formation of a high-density droplet array for nucleic acid quantification by digital LAMP with a random-access system	26
Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion	26
Inertial focusing of circulating tumor cells in whole blood at high flow rates using the microfluidic CTCKey™ device for CTC enrichment	26
Automated biophysical classification of apoptotic pancreatic cancer cell subpopulations by using machine learning approaches with impedance cytometry	26
Rapid nitrate determination with a portable lab-on-chip device based on double microstructured assisted reactors	26
A rapid nucleic acid concentration measurement system with large field of view for a droplet digital PCR microfluidic chip	26
Microfluidic formation of crystal-like structures	25
Microfluidic point-of-care device for detection of early strains and B.1.1.7 variant of SARS-CoV-2 virus	25
A graphene oxide coated tapered microfiber acting as a super-sensor for rapid detection of SARS-CoV-2	25
Fabrication of monodisperse alginate microgel beads by microfluidic picoinjection: a chelate free approach	25
A simple and reversible glass–glass bonding method to construct a microfluidic device and its application for cell recovery	25
Enzyme-based digital bioassay technology – key strategies and future perspectives	24
Three-dimensional imaging on a chip using optofluidics light-sheet fluorescence microscopy	24
Microfluidic-based in vitro thrombosis model for studying microplastics toxicity	24
Recent advances in integrated solid-state nanopore sensors	24
Measuring barrier function in organ-on-chips with cleanroom-free integration of multiplexable electrodes	24
Deep imaging flow cytometry	24
A microfluidic device enabling deterministic single cell trapping and release	24
A robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology	24
Tuning particle inertial separation in sinusoidal channels by embedding periodic obstacle microstructures	24
Integration of segmented microflow chemistry and online HPLC/MS analysis on a microfluidic chip system enabling enantioselective analyses at the nanoliter scale	24
Tunnel dielectrophoresis for ultra-high precision size-based cell separation	24
Establishment of a human three-dimensional chip-based chondro-synovial coculture joint model for reciprocal cross talk studies in arthritis research	24
Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies	24
Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy	23
Closed-loop feedback control of microfluidic cell manipulation via deep-learning integrated sensor networks	23
Immuno-biosensor on a chip: a self-powered microfluidic-based electrochemical biosensing platform for point-of-care quantification of proteins	23
Isolation and recovery of extracellular vesicles using optically-induced dielectrophoresis on an integrated microfluidic platform	23
Bacterial classification and antibiotic susceptibility testing on an integrated microfluidic platform	23
Microfluidic model with air-walls reveals fibroblasts and keratinocytes modulate melanoma cell phenotype, migration, and metabolism	22
Engineering a deformation-free plastic spiral inertial microfluidic system for CHO cell clarification in biomanufacturing	22
A microfluidic chip with a serpentine channel enabling high-throughput cell separation using surface acoustic waves	22
Label-free inertial-ferrohydrodynamic cell separation with high throughput and resolution	22
Acoustic valves in microfluidic channels for droplet manipulation	22
Multi-oscillation microrheology via acoustic force spectroscopy enables frequency-dependent measurements on endothelial cells at high-throughput	22
A sample-to-answer, quantitative real-time PCR system with low-cost, gravity-driven microfluidic cartridge for rapid detection of SARS-CoV-2, influenza A/B, and human papillomavirus 16/18	22
Cancer drug screening with an on-chip multi-drug dispenser in digital microfluidics	22
Emerging point-of-care technologies for anemia detection	22
Focused surface acoustic wave locally removes cells from culture surface	22
Optimized design of obstacle sequences for microfluidic mixing in an inertial regime	22
Zigzag microchannel for rigid inertial separation and enrichment (Z-RISE) of cells and particles	22
Oxygen control: the often overlooked but essential piece to create betterin vitrosystems	22
A review on microrobots driven by optical and magnetic fields	21
Microneedle-based transdermal detection and sensing devices	21
On-chip rapid drug screening of leukemia cells by acoustic streaming	21
Machine learning assisted fast prediction of inertial lift in microchannels	21
Generation of flow and droplets with an ultra-long-range linear concentration gradient	21
On the acoustically induced fluid flow in particle separation systems employing standing surface acoustic waves – Part I	21
Multi-parametric functional imaging of cell cultures and tissues with a CMOS microelectrode array	21
Disposable photonics for cost-effective clinical bioassays: application to COVID-19 antibody testing	21

Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip	21
Assessing red blood cell deformability from microscopy images using deep learning	21
Rapid isolation of circulating cancer associated fibroblasts by acoustic microstreaming for assessing metastatic propensity of breast cancer patients	21
Postoperative evaluation of tumours based on label-free acoustic separation of circulating tumour cells by microstreaming	21
High-throughput injection molded microfluidic device for single-cell analysis of spatiotemporal dynamics	21
Microfluidic droplet-based functional materials for cell manipulation	21
A microphysiological early metastatic niche on a chip reveals how heterotypic cell interactions and inhibition of integrin subunit β3 impact breast cancer cell extravasation	21
A microfluidic cartridge for fast and accurate diagnosis of Mycobacterium tuberculosis infections on standard laboratory equipment	21
Advances in droplet digital polymerase chain reaction on microfluidic chips	20
Biohybrid sensor for odor detection	20
A continuous flow PCR array microfluidic chip applied for simultaneous amplification of target genes of periodontal pathogens	20
High-throughput and label-free enrichment of malignant tumor cells and clusters from pleural and peritoneal effusions using inertial microfluidics	20
Engineering inclined orientations of piezoelectric films for integrated acoustofluidics and lab-on-a-chip operated in liquid environments	20
Self-aligned sequential lateral field non-uniformities over channel depth for high throughput dielectrophoretic cell deflection	20
Blood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research	20
Size-tuneable isolation of cancer cells using stretchable inertial microfluidics	20
Lab-in-a-pencil graphite: A 3D-printed microfluidic sensing platform for real-time measurement of antipsychotic clozapine level	20
Practical microcircuits for handheld acoustofluidics	20
Development of a human neuromuscular tissue-on-a-chip model on a 24-well-plate-format compartmentalized microfluidic device	20
Intestinal explant barrier chip: long-term intestinal absorption screening in a novel microphysiological system using tissue explants	20
A fully integrated biomimetic microfluidic device for evaluation of sperm response to thermotaxis and chemotaxis	20
Predicting the fluid behavior of random microfluidic mixers using convolutional neural networks	20
Microfluidics for antibiotic susceptibility testing	19
Multiplex amplification of target genes of periodontal pathogens in continuous flow PCR microfluidic chip	19
Recent advances in microfluidic devices for single-cell cultivation: methods and applications	19
Stromal cell identity modulates vascular morphogenesis in a microvasculature-on-a-chip platform	19
Flowmetering for microfluidics	19
Bridging the academic–industrial gap: application of an oxygen and pH sensor-integrated lab-on-a-chip in nanotoxicology	19
Point-of-care microchip electrophoresis for integrated anemia and hemoglobin variant testing	19
Human neuromuscular junction on micro-structured microfluidic devices implemented with a custom micro electrode array (MEA)	19
Cell-sorting centrifugal microfluidic chip with a flow rectifier	19
Parallel multistep digital analysis SlipChip demonstrated with the quantification of nucleic acid by digital LAMP-CRISPR	19
Healthy and diseased in vitro models of vascular systems	19
Flexural wave-based soft attractor walls for trapping microparticles and cells	19
Technologies for measuring red blood cell deformability	19
Automated sample-to-answer centrifugal microfluidic system for rapid molecular diagnostics of SARS-CoV-2	19
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips	18
Automated fluorescence quantification of extracellular vesicles collected from blood plasma using dielectrophoresis	18
Application of a gut–liver-on-a-chip device and mechanistic modelling to the quantitative in vitro pharmacokinetic study of mycophenolate mofetil	18
Lateral flow device for water fecal pollution assessment: from troubleshooting of its microfluidics using bioluminescence to colorimetric monitoring of generic Escherichia coli	18
Programmable motion control and trajectory manipulation of microparticles through tri-directional symmetrical acoustic tweezers	18
Recent microfluidic advances in submicron to nanoparticle manipulation and separation	18
An epidermal wearable microfluidic patch for simultaneous sampling, storage, and analysis of biofluids with counterion monitoring	18
Scaffold-free generation of heterotypic cell spheroids using acoustofluidics	18
Dosage-controlled intracellular delivery mediated by acoustofluidics for lab on a chip applications	18
Spatial trans-epithelial electrical resistance (S-TEER) integrated in organs-on-chips	18
High-throughput digital pathology via a handheld, multiplexed, and AI-powered ptychographic whole slide scanner	18
A polymer index-matched to water enables diverse applications in fluorescence microscopy	18
Monitoring the effects of chemical stimuli on live cells with metasurface-enhanced infrared reflection spectroscopy	18
Microfluidic technologies for immunotherapy studies on solid tumours	18
On-chip perivascularnichesupporting stemness of patient-derived glioma cells in a serum-free, flowable culture	18
Digital electrical impedance analysis for single bacterium sensing and antimicrobial susceptibility testing	18
A sequentially bioconjugated optofluidic laser for wash-out-free and rapid biomolecular detection	18
A photofabricated honeycomb micropillar array for loss-free trapping of microfluidic droplets and application to digital PCR	18
Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems	17
Quantitative particle agglutination assay for point-of-care testing using mobile holographic imaging and deep learning	17
3D micromixer for nanoliposome synthesis: a promising advance in high mass productivity	17
Flow shear stress controls the initiation of neovascularization via heparan sulfate proteoglycans within a biomimetic microfluidic model	17
An “occlusive thrombosis-on-a-chip” microfluidic device for investigating the effect of anti-thrombotic drugs	17
An antibiotic concentration gradient microfluidic device integrating surface-enhanced Raman spectroscopy for multiplex antimicrobial susceptibility testing	17
Microfluidic single-cell transcriptomics: moving towards multimodal and spatiotemporal omics	17
Versatile acoustic manipulation of micro-objects using mode-switchable oscillating bubbles: transportation, trapping, rotation, and revolution	17
Deep learning detector for high precision monitoring of cell encapsulation statistics in microfluidic droplets	17
Fluidic circuit board with modular sensor and valves enables stand-alone, tubeless microfluidic flow control in organs-on-chips	17
Microfluidic generation of ATPS droplets by transient double emulsion technique	17
Bio-inspired fractal textile device for rapid sweat collection and monitoring	17
Microfluidic studies of hydrostatic pressure-enhanced doxorubicin resistance in human breast cancer cells	17
Sheathless and high-throughput elasto-inertial bacterial sorting for enhancing molecular diagnosis of bloodstream infection	17
Origami paper-based sample preconcentration using sequentially driven ion concentration polarization	17
Low-cost rapid prototyping and assembly of an open microfluidic device for a 3D vascularized organ-on-a-chip	16
Hotspots of root-exuded amino acids are created within a rhizosphere-on-a-chip	16
Extraction of small extracellular vesicles by label-free and biocompatible on-chip magnetic separation	16
Sub-micron thick liquid sheets produced by isotropically etched glass nozzles	16
Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response	16
High performance inkjet printed embedded electrochemical sensors for monitoring hypoxia in a gut bilayer microfluidic chip	16
High-throughput microfluidic compressibility cytometry using multi-tilted-angle surface acoustic wave	16
Go with the flow: modeling unique biological flows in engineeredin vitroplatforms	16
Label-free detection and enumeration of rare circulating tumor cells by bright-field image cytometry and multi-frame image correlation analysis	16
IL-2 secretion-based sorting of single T cells using high-throughput microfluidic on-cell cytokine capture	16
Shape-based separation of drug-treated Escherichia coli using viscoelastic microfluidics	16
A microfluidic hanging drop-based spheroid co-culture platform for probing tumor angiogenesis	16
Efficient and gentle delivery of molecules into cells with different elasticity via Progressive Mechanoporation	16
Advanced continuous-flow microfluidic device for parallel screening of crystal polymorphs, morphology, and kinetics at controlled supersaturation	16
Directional anchoring patterned liquid-infused superamphiphobic surfaces for high-throughput droplet manipulation	16
Microfluidic acoustic sawtooth metasurfaces for patterning and separation using traveling surface acoustic waves	16
Small intestinal sampling capsule for inflammatory bowel disease type detection and management	16
Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy	16
On-board smartphone micromotor-based fluorescence assays	16
Size and density measurements of single sickle red blood cells using microfluidic magnetic levitation	16
Super-resolution optofluidic scanning microscopy	16
Label-free three-dimensional observations and quantitative characterisation of on-chip vasculogenesis using optical diffraction tomography	15
Cilo-seq: highly sensitive cell-in-library-out single-cell transcriptome sequencing with digital microfluidics	15
A survey of 3D printing technology applied to paper microfluidics	15
Synchronous control of magnetic particles and magnetized cells in a tri-axial magnetic field	15
Surfactant-laden droplet size prediction in a flow-focusing microchannel: a data-driven approach	15