OOIR: Observatory of International Research

Papers

(The TQCC of Tuberculosis is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Constructive appraisal of Zhong et al.’s study on Mycobacterium tuberculosis dormant antigens and PB2-DIMQ vaccine: Opportunities for translational strengthening	63
Sensitive lipid biomarker detection for tuberculosis in late Neanderthal skeletons from Subalyuk Cave, Hungary	46
IgG antibody response to Mycobacterium tuberculosis curli pili (MTP) in people from different geographical regions in Sub-Saharan Africa	35
MicroRNAs in exhaled breath Condensate: Novel non-invasive biomarkers for tuberculosis diagnosis	34
Enhanced efficacy of BCG vaccine formulated in adjuvant is dependent on IL-17A expression	31
A novel chemogenomic discovery platform identifies bioactive hits with rapid bactericidal activity against Mycobacteroides Abscessus	28
Editorial Board	26
Predictive biomarkers for latent Mycobacterium tuberculosis infection	25
The Rv3874-Rv3875 chimeric protein shows a promiscuous serodiagnostic potential for tuberculosis	25
Upper Paleolithic tuberculosis: A probable case illustrated by paleoimaging methods (Azilian site of Les Iboussières, France)	24
Preclinical tests for salicylhydrazones derivatives to explore their potential for new antituberculosis agents	23
The use of Mycobacterium tuberculosis H37Ra-infected immunocompetent mice as an in vivo model of persisters	22
Responses to comments on “A comparative study between milk- and serum-based antibody detection assays for Johne's disease in New Zealand dairy cattle”	22
Exhaled breath analysis: A promising triage test for tuberculosis in young children	20
Mycobacterium bovis mutant in the virulence factors PhoP, ESAT-6 and CFP-10 persisted in mouse organs after a year post-vaccination	20
The evaluation of Phenylalanine-tRNA ligase beta unit (PheT), as a potential target in Mycobacterium abscessus	18
Immunogenicity and protection against Mycobacterium avium with a heterologous RNA prime and protein boost vaccine regimen	17
Tuberculosis and autoimmunity: Common features	17
Editorial Board	15
GlfT1 down-regulation affects Mycobacterium tuberculosis biofilm formation and its in-vitro and in-vivo survival	15
The immunomodulatory effects of Mesenchymal stem cells on THP-1-derived macrophages against Mycobacterium tuberculosis H37Ra infection	15
METTL3 contributes to M.tb-induced injury and inflammation in THP-1 macrophages by mediating m6A methylation of IRF8 to activate TLR4/NF-kB pathway	14
Editorial Board	14
Assessment of DNA aptamers targeting GlcB and HspX antigens for application in the diagnosis of abdominal tuberculosis	14
Utilization of Truenat chips in defining XDR, pre-XDR and MDR in tuberculous meningitis	14

Low performance of interferon gamma release assay Quantiferon-TB gold coupled or not with Pst1/3/lipoglycan humoral detection to predict Mycobacterium tuberculosis complex disease in a low-burden area	13
An immunocompetent rat model of Mycobacterium abscessus multinodular granulomatous lung infection	13
Nanotechnology and tuberculosis: An old disease with new treatment strategies	13
Macrophage-targeted versus free calcitriol as host-directed adjunct therapy against Mycobacterium tuberculosis infection in mice is bacteriostatic and mitigates tissue pathology	13
In-vivo expressed mycobacterial transcripts as diagnostic targets for pulmonary tuberculosis	12
Cerebrospinal fluid AFB smear in adults with tuberculous meningitis: A systematic review and diagnostic test accuracy meta-analysis	12
Implementation of a mycobacterial CRISPRi platform in Mycobacterium abscessus and demonstration of the essentiality of ftsZ	12
Oldest evidence of tuberculosis in the Mediterranean islands: From the mainland to Cyprus	12
The role of programmed cell death pathways in the host response to Mycobacterium tuberculosis: Insights from gene expression analysis in active pulmonary tuberculosis patients	12
Leprosy: The age-old companion of humans – Re-evaluation and comparative analysis of Avar-period cases with Hansen's disease from the Danube-Tisza Interfluve, Hungary	11
Epidemiology and molecular characterization of Mycobacterium tuberculosis including a drug-resistant strain associated with mortality of Asian elephants in Nepal 2019–2022	11
Evaluation of immune profiles associated with control of mycobacterial growth in systemic lupus erythematosus (SLE) patients	11
Characterizing in vivo loss of virulence of an HN878 Mycobacterium tuberculosis isolate from a genetic duplication event	11
Construction and expression of multi-stage antigen fusion protein RPC4 vaccine for Mycobacterium tuberculosis and its immunogenicity analysis in combination with adjuvant DIMQ	11
Serodiagnosis of paucibacillary and multibacillary leprosy using a recombinant chimeric protein composed of specific B-cell epitopes derived from Mycobacterium leprae proteins	11
Editorial Board	11
"Tuberculosis on the spot" – Discussion of a probable sternal tuberculosis from a late medieval cemetery from Hungary	11
Culture independent markers of nontuberculous mycobacterial (NTM) lung infection and disease in the cystic fibrosis airway	11
Proteome and immunogenicity differences in BCG Pasteur ATCC 35734 and its derivative, the vaccine candidate BCGΔBCG1419c during planktonic growth in 7H9 and Proskauer Beck media	11
Activating transcription factor 3 protects alveolar epithelial type II cells from Mycobacterium tuberculosis infection-induced inflammation	10
Efficient cell model for assessing inflammatory responsive genes in Mycobacterium tuberculosis and SARS-CoV-2 co-infection	10
Stimulated expression of ELR+ chemokines, VEGFA and TNF-AIP3 promote mycobacterial dissemination in extrapulmonary tuberculosis patients and Cavia porcellus model of tuberculosis	10
Replication and transmission features of two experimental vaccine candidates against bovine tuberculosis subcutaneously administrated in a murine model	10
Letter to Editor: manuscript entitled “Utility of pleural fluid-derived extracellular vesicles as a source of Mycobacterium tuberculosis antigens MPT51 and MPT64 for pleural TB diagnosis: a proof-of-c	10
Corrigendum to “Inhibition of mycobacteria proliferation in macrophages by diaryl ether derivatives of Dehydrozingerone compound and repurposed drugs (Rebamipide, Sofalcone) via NF-κB pathway inhibiti	10
Microneedle-mediated intradermal delivery of Bacille Calmette-Guérin (BCG) vaccines for single-dose tuberculosis vaccination	10
Host urinary biomarkers in HIV positive and HIV negative patients with tubercular uveitis and other uveitic diseases	10
Diagnostic value of five Mycobacterium tuberculosis dormant highly expressed antigens in latent infections and immunogenicity assessment of a novel subunit vaccine PB2-DIMQ	10
Transmission of drug-resistant Mycobacterium tuberculosis isolates between Finnish- and foreign-born cases, 2014–2021: A molecular epidemiological study	10
A comparative study between milk- and serum-based antibody detection assays for Johne's disease in New Zealand dairy cattle	10
Analysis and comparison of image processing and artificial intelligence algorithms to detect AFB in pulmonary tuberculosis images	9
Effect of Metformin on systemic chemokine responses during anti-tuberculosis chemotherapy	9
Targeting HspX of Mycobacterium tuberculosis: Advances in diagnostics, treatment, and vaccine development	9
Adaptation to the intracellular environment of primary human macrophages influences drug susceptibility of Mycobacterium tuberculosis	9
In vitro and in vivo antibacterial activity of sudapyridine (WX-081) combined with other drugs against Mycobacterium abscessus	9
METTL3-deficiency m6A-dependently degrades MALAT1 to suppress NLRP3-mediated pyroptotic cell death and inflammation in Mycobacterium tuberculosis (H37Ra strain)-infected mouse macrophages	9
Towards the development of subunit vaccines against tuberculosis: The key role of adjuvant	9
Response to letter: Protocol signals or study effects in direct sputum whole-genome sequencing of Mycobacterium tuberculosis?	8
Assessment of transcriptional markers for the differentiation of Mycobacterium mungi infection status in free-ranging banded mongoose (Mungos mungo)	8
Rv3371, a triacylglycerol synthase promotes survival of Mycobacterium tuberculosis in the host through its contributions to redox homeostasis and propionate detoxification	8
Lumbosacral tuberculosis, a rare manifestation of Pott's disease – How identified human skeletons from the pre-antibiotic era can be used as reference cases to establish a palaeopathological diagnosis	8
In vitro and in vivo activities of a novel benzothiopyranone candidate NTB-3119M against Mycobacterium tuberculosis	8
Steroid immune responsive gene regulation in Mycobacterium tuberculosis infection in vitro	8
Pharmacogenetic testing for NAT2 genotypes in a Tanzanian population across the lifespan to guide future personalized isoniazid dosing	8
CountFU: Ditching CFUs for qPCR enumeration of Mycobacterium tuberculosis and a call to join the revolution	8
Mycobacterium bovis BCG dodecin gene codes a functional protein despite of a start codon mutation	8
Integrative and comparative genomic analyses of mammalian macrophage responses to intracellular mycobacterial pathogens	8
Increasing circulation of multi-drug resistant tuberculosis strains in Buryatia, high-burden and ethnically diverse region in the Russian Far East	8
Response to “Correspondence on ‘Analysis of the cross-study replicability of tuberculosis gene signatures using 49 curated human transcriptomic datasets’”	7
Genomic comparison of two strains of Mycobacterium avium subsp. paratuberculosis with contrasting pathogenic phenotype	7

Editorial Board	7
Deferiprone-gallium-protoporphyrin (IX): A promising treatment modality against Mycobacterium abscessus	7
Analysis of the cross-study replicability of tuberculosis gene signatures using 49 curated human transcriptomic datasets	7
Response to “Prevalence of non-tuberculous mycobacteria by Line-Probe Assay”	7
The paradoxes of Mycobacterium tuberculosis molecular evolution and consequences for the inference of tuberculosis emergence date	7
Mab2780c, a TetV-like efflux pump, confers high-level spectinomycin resistance in mycobacterium abscessus	6
Computational drug repositioning identifies niclosamide and tribromsalan as inhibitors of Mycobacterium tuberculosis and Mycobacterium abscessus	6
Hippocampal syndrome secondary to tuberculosis: From neuroinflammation to neurodegeneration	6
Spray dried tigecycline dry powder aerosols for the treatment of Nontuberculous mycobacterial pulmonary infections	6
Demonstration of extracellular traps in tuberculous pleural effusion from adult patients.	6
Raman spectroscopy and machine learning-based optical probe for tuberculosis diagnosis via sputum	6
Enhanced immunogenicity of the tuberculosis subunit Rv0572c vaccine delivered in DMT liposome adjuvant as a BCG-booster	6
Plasma biomarkers CRP, iFABP, and zonulin as predictors of tuberculosis progression in household contacts of pulmonary TB patients	6
Analysis of genetic characteristics associated with reduced bedaquiline susceptibility in multidrug-resistant Mycobacterium tuberculosis	6
Detection of Mycobacterium tuberculosis complex in saliva by quantitative PCR: A potential alternative specimen for pulmonary tuberculosis diagnosis	6
Analysis of tuberculosis infection dynamics using Caputo fractional-order models with diagnosis and treatment interventions	6
Mycobacterial growth control is heterogeneous but maintained during treatment in patients with tuberculosis disease	6
Identification of BMVC-8C3O as a novel Pks13 inhibitor with anti-tuberculosis activity	6
Gut bacterial diversity in bovines infected with Mycobacterium tuberculosis var. bovis: insights on tuberculosis pathogenesis	6
Flow cytometry-based method using diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease	6
Editorial Board	6
Utility of pleural fluid-derived extracellular vesicles as a source of Mycobacterium tuberculosis antigens MPT51 and MPT64 for pleural TB diagnosis: a proof-of-concept study	6
Molecular epidemiology of tuberculosis in the general and prison populations in the interior of São Paulo: analysis of MIRU-VNTR and RDRio sublineage	6
The PPE2 protein of Mycobacterium tuberculosis is secreted during infection and facilitates mycobacterial survival inside the host	6
Transient, inhaled gene therapy with gamma interferon mitigates pathology induced by host response in a mouse model of tuberculosis	5
Identification of host immune-related biomarkers in active tuberculosis: A comprehensive analysis of differentially expressed genes	5
Functional analysis of genetic mutations in ddn and fbiA linked to delamanid resistance in rifampicin-resistant Mycobacterium tuberculosis	5
Tuberculosis in prehistory in Eastern Central Europe (Hungary) – Chronological and geographical distribution	5
Analysis of T-lymphocyte subsets and risk factors in children with tuberculosis	5
Towards model-informed precision dosing of clofazimine, moxifloxacin, and terizidone/cycloserine in the treatment of drug-resistant tuberculosis: An external model evaluation study	5
Comments on “A comparative study between milk- and serum-based antibody detection assays for Johne's disease in New Zealand dairy cattle”	5
Treatment of tuberculous meningitis: Overdue for concerted action	5
The impact of genotype on the phenotype of Mycobacterium tuberculosis ΔsufR mutants	5
Functional impact of a deletion in Mycobacterium bovis BCG Moreau celA1 gene	5
Non-tuberculosis mycobacteria identified by line probe assays in respiratory and non-respiratory samples in South Africa between 2015 and 2019	5
Unraveling the metabolism of Mycobacterium caprae using comparative genomics	5
Epigenetic regulation of the immune response to Mycobacterium bovis infection in cattle: potential implications for diagnostic test sensitivity	5
Identification of an autophagy-related novel signature for spinal tuberculosis: a multi-cohort machine learning study and Mendelian randomization analysis	5
Reduced host cell-free DNA as a biomarker in latent tuberculosis infection among tuberculosis contacts	5
Knockdown of argininosuccinate lyase influences the growth of Mycolicibacterium smegmatis in vitro and in vivo	5
The expression of Nramp1 modulates the uptake of Mycobacterium tuberculosis by macrophages through alternating inflammatory responses	5
Inability of the BCG vaccine to protect mice of the H2f haplotype at advanced stages of TB infection is associated with defective CD4+ T-cell activation in spleen	5
Evaluation of AAICare®-TB sequence analysis tool for accurate diagnosis of drug-resistant tuberculosis: A comparative study with TB-Profiler and Mykrobe	5
Commentary on the potential effects of infection with Mycobacterium bovis during the first days of life on the immune response to, and performance of diagnostics for the detection of, infection with M	5
Corrigendum to “Down regulation of RANTES in pleural site is associated with inhibition of antigen specific response in tuberculosis” [Tuberculosis 116 (Supplement) (2019) S123–S130]	5
In silico identification of quinoline-pyridine hybrids binding to Mycobacterium protein kinase B, assessment by molecular dynamics simulation and quantum mechanics calculation, and in vitro validation	5
Fluctuations in circulating cell-free mitochondrial and nuclear DNA copy numbers in blood plasma after anti-tuberculosis drug intake in patients with drug-susceptible tuberculosis	5
Proteome overview of exosome derived from plasma of cows infected with Mycobacterium bovis	5
“The cytokine profiles of the inflammatory response in chronic granulomatous encephalitis caused by Mycobacterium tuberculosis do not influence the patient's clinical presentation"	5
A simplified and efficient method for single-step, targeted gene deletion in mycobacteria	5
Lysosomal enzymes and the oxygen burst capability of monocyte-derived macrophages in active drug-resistant tuberculosis patients in relation to cell attachment	5
Synergistic role of Mycobacterium indicus pranii and human beta Defensin-2 as adjunctive therapy against Mycobacterium tuberculosis	5
Differences in biomarker concentrations in serum and urine of patients with Ocular Tuberculosis – A prospective descriptive study	5
Metformin modulates corticosteroids hormones in adrenals cells promoting Mycobacterium tuberculosis elimination in human macrophages	5
Necrosis, netosis, and apoptosis in pulmonary tuberculosis and type-2 diabetes mellitus. Clues from the patient's serum	5
Characterization of the global bovine microRNAome of peripheral blood mononuclear cells isolated from Mycobacterium bovis exposed cattle	5