OOIR: Observatory of International Research

Papers

(The TQCC of Tuberculosis is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Mycobacterium bovis mutant in the virulence factors PhoP, ESAT-6 and CFP-10 persisted in mouse organs after a year post-vaccination	57
Preclinical tests for salicylhydrazones derivatives to explore their potential for new antituberculosis agents	40
Predictive biomarkers for latent Mycobacterium tuberculosis infection	29
Tuberculosis and autoimmunity: Common features	28
IgG antibody response to Mycobacterium tuberculosis curli pili (MTP) in people from different geographical regions in Sub-Saharan Africa	28
The evaluation of Phenylalanine-tRNA ligase beta unit (PheT), as a potential target in Mycobacterium abscessus	28
Enhanced efficacy of BCG vaccine formulated in adjuvant is dependent on IL-17A expression	26
Sensitive lipid biomarker detection for tuberculosis in late Neanderthal skeletons from Subalyuk Cave, Hungary	25
A novel chemogenomic discovery platform identifies bioactive hits with rapid bactericidal activity against Mycobacteroides Abscessus	24
Biofilms in tuberculosis: What have we learnt in the past decade and what is still unexplored?	23
Editorial Board	22
The use of Mycobacterium tuberculosis H37Ra-infected immunocompetent mice as an in vivo model of persisters	21
Editorial Board	21
MicroRNAs in exhaled breath Condensate: Novel non-invasive biomarkers for tuberculosis diagnosis	20
The Rv3874-Rv3875 chimeric protein shows a promiscuous serodiagnostic potential for tuberculosis	20
Domestic pigs experimentally infected with Mycobacterium bovis and Mycobacterium tuberculosis exhibit different disease outcomes	20
Upper Paleolithic tuberculosis: A probable case illustrated by paleoimaging methods (Azilian site of Les Iboussières, France)	19
Immunogenicity and protection against Mycobacterium avium with a heterologous RNA prime and protein boost vaccine regimen	19
Exhaled breath analysis: A promising triage test for tuberculosis in young children	18
Constructive appraisal of Zhong et al.’s study on Mycobacterium tuberculosis dormant antigens and PB2-DIMQ vaccine: Opportunities for translational strengthening	17
GlfT1 down-regulation affects Mycobacterium tuberculosis biofilm formation and its in-vitro and in-vivo survival	15
Editorial Board	15
Editorial Board	15
The immunomodulatory effects of Mesenchymal stem cells on THP-1-derived macrophages against Mycobacterium tuberculosis H37Ra infection	14
Cerebrospinal fluid AFB smear in adults with tuberculous meningitis: A systematic review and diagnostic test accuracy meta-analysis	13

An immunocompetent rat model of Mycobacterium abscessus multinodular granulomatous lung infection	13
Utilization of Truenat chips in defining XDR, pre-XDR and MDR in tuberculous meningitis	13
METTL3 contributes to M.tb-induced injury and inflammation in THP-1 macrophages by mediating m6A methylation of IRF8 to activate TLR4/NF-kB pathway	13
Assessment of DNA aptamers targeting GlcB and HspX antigens for application in the diagnosis of abdominal tuberculosis	13
In-vivo expressed mycobacterial transcripts as diagnostic targets for pulmonary tuberculosis	12
Macrophage-targeted versus free calcitriol as host-directed adjunct therapy against Mycobacterium tuberculosis infection in mice is bacteriostatic and mitigates tissue pathology	12
Low performance of interferon gamma release assay Quantiferon-TB gold coupled or not with Pst1/3/lipoglycan humoral detection to predict Mycobacterium tuberculosis complex disease in a low-burden area	12
Oldest evidence of tuberculosis in the Mediterranean islands: From the mainland to Cyprus	11
Editorial Board	11
Characterizing in vivo loss of virulence of an HN878 Mycobacterium tuberculosis isolate from a genetic duplication event	11
Nanotechnology and tuberculosis: An old disease with new treatment strategies	11
"Tuberculosis on the spot" – Discussion of a probable sternal tuberculosis from a late medieval cemetery from Hungary	11
Evaluation of immune profiles associated with control of mycobacterial growth in systemic lupus erythematosus (SLE) patients	11
Implementation of a mycobacterial CRISPRi platform in Mycobacterium abscessus and demonstration of the essentiality of ftsZ	11
Serodiagnosis of paucibacillary and multibacillary leprosy using a recombinant chimeric protein composed of specific B-cell epitopes derived from Mycobacterium leprae proteins	11
Proteome and immunogenicity differences in BCG Pasteur ATCC 35734 and its derivative, the vaccine candidate BCGΔBCG1419c during planktonic growth in 7H9 and Proskauer Beck media	11
Leprosy: The age-old companion of humans – Re-evaluation and comparative analysis of Avar-period cases with Hansen's disease from the Danube-Tisza Interfluve, Hungary	11
Host urinary biomarkers in HIV positive and HIV negative patients with tubercular uveitis and other uveitic diseases	10
Transmission of drug-resistant Mycobacterium tuberculosis isolates between Finnish- and foreign-born cases, 2014–2021: A molecular epidemiological study	10
Epidemiology and molecular characterization of Mycobacterium tuberculosis including a drug-resistant strain associated with mortality of Asian elephants in Nepal 2019–2022	10
Construction and expression of multi-stage antigen fusion protein RPC4 vaccine for Mycobacterium tuberculosis and its immunogenicity analysis in combination with adjuvant DIMQ	10
Microneedle-mediated intradermal delivery of Bacille Calmette-Guérin (BCG) vaccines for single-dose tuberculosis vaccination	10
Replication and transmission features of two experimental vaccine candidates against bovine tuberculosis subcutaneously administrated in a murine model	10
Culture independent markers of nontuberculous mycobacterial (NTM) lung infection and disease in the cystic fibrosis airway	10
METTL3-deficiency m6A-dependently degrades MALAT1 to suppress NLRP3-mediated pyroptotic cell death and inflammation in Mycobacterium tuberculosis (H37Ra strain)-infected mouse macrophages	10
Efficient cell model for assessing inflammatory responsive genes in Mycobacterium tuberculosis and SARS-CoV-2 co-infection	10
An accurate artificial intelligence system for the detection of pulmonary and extra pulmonary Tuberculosis	10
Adaptation to the intracellular environment of primary human macrophages influences drug susceptibility of Mycobacterium tuberculosis	9
A comparative study between milk- and serum-based antibody detection assays for Johne's disease in New Zealand dairy cattle	9
Towards the development of subunit vaccines against tuberculosis: The key role of adjuvant	9
Ferroptosis-related gene SOCS1, a marker for tuberculosis diagnosis and treatment, involves in macrophage polarization and facilitates bone destruction in tuberculosis	9
Letter to Editor: manuscript entitled “Utility of pleural fluid-derived extracellular vesicles as a source of Mycobacterium tuberculosis antigens MPT51 and MPT64 for pleural TB diagnosis: a proof-of-c	9
Analysis and comparison of image processing and artificial intelligence algorithms to detect AFB in pulmonary tuberculosis images	9
Stimulated expression of ELR+ chemokines, VEGFA and TNF-AIP3 promote mycobacterial dissemination in extrapulmonary tuberculosis patients and Cavia porcellus model of tuberculosis	9
Targeting HspX of Mycobacterium tuberculosis: Advances in diagnostics, treatment, and vaccine development	9
Activating transcription factor 3 protects alveolar epithelial type II cells from Mycobacterium tuberculosis infection-induced inflammation	9
Diagnostic value of five Mycobacterium tuberculosis dormant highly expressed antigens in latent infections and immunogenicity assessment of a novel subunit vaccine PB2-DIMQ	9
Effect of Metformin on systemic chemokine responses during anti-tuberculosis chemotherapy	8
Rv3371, a triacylglycerol synthase promotes survival of Mycobacterium tuberculosis in the host through its contributions to redox homeostasis and propionate detoxification	8
Mycobacterium bovis BCG dodecin gene codes a functional protein despite of a start codon mutation	8
Increasing circulation of multi-drug resistant tuberculosis strains in Buryatia, high-burden and ethnically diverse region in the Russian Far East	8
Integrative and comparative genomic analyses of mammalian macrophage responses to intracellular mycobacterial pathogens	8
In vitro and in vivo antibacterial activity of sudapyridine (WX-081) combined with other drugs against Mycobacterium abscessus	8
In vitro and in vivo activities of a novel benzothiopyranone candidate NTB-3119M against Mycobacterium tuberculosis	8
Steroid immune responsive gene regulation in Mycobacterium tuberculosis infection in vitro	8
Lumbosacral tuberculosis, a rare manifestation of Pott's disease – How identified human skeletons from the pre-antibiotic era can be used as reference cases to establish a palaeopathological diagnosis	8
Editorial Board	8
CountFU: Ditching CFUs for qPCR enumeration of Mycobacterium tuberculosis and a call to join the revolution	8
Assessment of transcriptional markers for the differentiation of Mycobacterium mungi infection status in free-ranging banded mongoose (Mungos mungo)	8
Franz Tappeiner (1816–1902) and his pioneering studies on tuberculosis	8

Identification of anti-lipoarabinomannan antibodies against mannan core and their effects on phagocytosis of mycobacteria by human neutrophils	8
Analysis of the cross-study replicability of tuberculosis gene signatures using 49 curated human transcriptomic datasets	7
Pharmacogenetic testing for NAT2 genotypes in a Tanzanian population across the lifespan to guide future personalized isoniazid dosing	7
Editorial Board	7
The paradoxes of Mycobacterium tuberculosis molecular evolution and consequences for the inference of tuberculosis emergence date	7
Enhanced immunogenicity of the tuberculosis subunit Rv0572c vaccine delivered in DMT liposome adjuvant as a BCG-booster	7
Response to “Prevalence of non-tuberculous mycobacteria by Line-Probe Assay”	7
Concurrent evaluation of cytokines improves the accuracy of antibodies against Mycobacterium tuberculosis antigens in the diagnosis of active tuberculosis	7
Computational drug repositioning identifies niclosamide and tribromsalan as inhibitors of Mycobacterium tuberculosis and Mycobacterium abscessus	7
Genomic comparison of two strains of Mycobacterium avium subsp. paratuberculosis with contrasting pathogenic phenotype	7
Distinct blood transcriptomic signature of treatment in latent tuberculosis infected individuals at risk of developing active disease	6
Raman spectroscopy and machine learning-based optical probe for tuberculosis diagnosis via sputum	6
Editorial Board	6
The PPE2 protein of Mycobacterium tuberculosis is secreted during infection and facilitates mycobacterial survival inside the host	6
Spray dried tigecycline dry powder aerosols for the treatment of Nontuberculous mycobacterial pulmonary infections	6
Flow cytometry-based method using diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease	6
Deferiprone-gallium-protoporphyrin (IX): A promising treatment modality against Mycobacterium abscessus	6
Gut bacterial diversity in bovines infected with Mycobacterium tuberculosis var. bovis: insights on tuberculosis pathogenesis	6
Hippocampal syndrome secondary to tuberculosis: From neuroinflammation to neurodegeneration	6
Down-regulation of GAS5 has diagnostic value for tuberculosis and regulates the inflammatory response in mycobacterium tuberculosis infected THP-1 cells	6
Mycobacterium abscessus drug discovery using machine learning	6
Analysis of genetic characteristics associated with reduced bedaquiline susceptibility in multidrug-resistant Mycobacterium tuberculosis	6
Detection of Mycobacterium tuberculosis complex in saliva by quantitative PCR: A potential alternative specimen for pulmonary tuberculosis diagnosis	6
Response to “Correspondence on ‘Analysis of the cross-study replicability of tuberculosis gene signatures using 49 curated human transcriptomic datasets’”	6
Synergistic role of Mycobacterium indicus pranii and human beta Defensin-2 as adjunctive therapy against Mycobacterium tuberculosis	5
Knockdown of argininosuccinate lyase influences the growth of Mycolicibacterium smegmatis in vitro and in vivo	5
Utility of pleural fluid-derived extracellular vesicles as a source of Mycobacterium tuberculosis antigens MPT51 and MPT64 for pleural TB diagnosis: a proof-of-concept study	5
Evaluation of AAICare®-TB sequence analysis tool for accurate diagnosis of drug-resistant tuberculosis: A comparative study with TB-Profiler and Mykrobe	5
The expression of Nramp1 modulates the uptake of Mycobacterium tuberculosis by macrophages through alternating inflammatory responses	5
Inability of the BCG vaccine to protect mice of the H2f haplotype at advanced stages of TB infection is associated with defective CD4+ T-cell activation in spleen	5
Transient, inhaled gene therapy with gamma interferon mitigates pathology induced by host response in a mouse model of tuberculosis	5
“The cytokine profiles of the inflammatory response in chronic granulomatous encephalitis caused by Mycobacterium tuberculosis do not influence the patient's clinical presentation"	5
Treatment of tuberculous meningitis: Overdue for concerted action	5
Identification of host immune-related biomarkers in active tuberculosis: A comprehensive analysis of differentially expressed genes	5
A simplified and efficient method for single-step, targeted gene deletion in mycobacteria	5
Lysosomal enzymes and the oxygen burst capability of monocyte-derived macrophages in active drug-resistant tuberculosis patients in relation to cell attachment	5
Mab2780c, a TetV-like efflux pump, confers high-level spectinomycin resistance in mycobacterium abscessus	5
Analysis of tuberculosis infection dynamics using Caputo fractional-order models with diagnosis and treatment interventions	5
Reduced host cell-free DNA as a biomarker in latent tuberculosis infection among tuberculosis contacts	5
Metformin modulates corticosteroids hormones in adrenals cells promoting Mycobacterium tuberculosis elimination in human macrophages	5
Fluctuations in circulating cell-free mitochondrial and nuclear DNA copy numbers in blood plasma after anti-tuberculosis drug intake in patients with drug-susceptible tuberculosis	5
Functional impact of a deletion in Mycobacterium bovis BCG Moreau celA1 gene	5
Whole-genome sequencing as a tool for studying the microevolution of drug-resistant serial Mycobacterium tuberculosis isolates	5
Functional analysis of genetic mutations in ddn and fbiA linked to delamanid resistance in rifampicin-resistant Mycobacterium tuberculosis	5
Analysis of T-lymphocyte subsets and risk factors in children with tuberculosis	5
Identification of BMVC-8C3O as a novel Pks13 inhibitor with anti-tuberculosis activity	5
Tuberculosis in prehistory in Eastern Central Europe (Hungary) – Chronological and geographical distribution	5
Differences in biomarker concentrations in serum and urine of patients with Ocular Tuberculosis – A prospective descriptive study	5
Non-tuberculosis mycobacteria identified by line probe assays in respiratory and non-respiratory samples in South Africa between 2015 and 2019	5
Epigenetic regulation of the immune response to Mycobacterium bovis infection in cattle: potential implications for diagnostic test sensitivity	5
The impact of genotype on the phenotype of Mycobacterium tuberculosis ΔsufR mutants	5
Evaluating the effects of Cyclosporine A immunosuppression on Mycobacterial infection by inhaling of Cyclosporine A administrated BALB/c mice with live Bacillus Calmette Guérin	5