OOIR: Observatory of International Research

Papers

(The TQCC of Expert Opinion on Therapeutic Targets is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects	91
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA	68
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines	49
Emergent RNA targets in cardiovascular disease: likely candidates for treatment development	46
P2 receptors as emerging therapeutic targets in neglected parasitic diseases	41
Mitochondrial permeability transition pore: a snapshot of a therapeutic target	40
CDK7 as a New therapeutic target in pancreatic and lung cancer: current evidence and future perspectives	39
Interleukin-18 in cancer immunology and immunotherapy	39
Targeting transcription in neuroblastoma: focus on the core regulatory circuit	36
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy	33
Glycoproteins and longevity: an interview with Professor Gordan Lauc	32
Molecular basis for targeting TBK1 in CAR-T cell therapies for cancer	32
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement	28
The protective role of SIRT1 in cardiovascular disease: from molecular mechanisms to potential therapeutic strategies	28
The membrane receptor CD44: roles in neurodegenerative diseases	28
Blocking glycan production by targeting GALNT7 for prostate cancer therapy	26
The sigma–1 receptor: a mechanistically–informed therapeutic target for antidepressants	26
Current challenges in the discovery of treatments against Mayaro fever	25
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer	25
The role of human complement factor H in retinal immune response and the prospects for targeted therapy for age-related macular degeneration (AMD)	25
Identification of target sites in the VHR (DUSP3) enzyme unlocking potential avenues for future sepsis treatment	25
The potential of multimolecular G-quadruplex structures for targeted treatment of Amyotrophic Lateral Sclerosis	24
Advances in CGRP therapeutic targets for migraine: where do we stand 5 years later?	24
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets	23
The challenges and potential of microRNA-based therapy for patients with liver failure syndromes and hepatocellular carcinoma	23

MDA-9/Syntenin as a therapeutic cancer metastasis target: current molecular and preclinical understanding	23
Bridging neurotransmission and tumor biology: the emerging focus on CHRM1 in skin cancer therapy	22
Novel signatures of prostate cancer progression and therapeutic resistance	21
Antibacterial carbonic anhydrase inhibitors targeting Vibrio cholerae enzymes	21
Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy	20
KRAS mutations in colorectal cancer: impacts on tumor microenvironment and therapeutic implications	20
Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis	20
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age	20
The PDPK1–RSK2 axis as a potential convergent therapeutic vulnerability in B-cell lymphomas	19
Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABA_B R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model	19
Breakthroughs in our molecular understanding of therapeutic targets for pulmonary hypertension	19
What do we know about the renin angiotensin system and inflammatory bowel disease?	18
Targeting inflammatory persistence in axial spondyloarthritis: from cytokine blockade to pathway convergence	18
Molecular pharmacology of multitarget cyclin-dependent kinase inhibitors in human colorectal carcinoma cells	18
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling	18
Lipopolysaccharide-targeting treatments for multidrug-resistant Pseudomonas aeruginosa	18
RBM47 as a therapeutic target in selected human diseases	18
The trap becomes the target: molecular basis for targeted inhibition of neutrophil extracellular traps in the pre-metastatic niche	18
Promising therapeutic targets for the treatment of urine storage dysfunction: what’s the status?	18
The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin	17
Targeting PRL phosphatases in hematological malignancies	17
APE1/Ref-1: multifunctional biology, selective inhibition, and the path to clinical translation	17
Novel therapeutic targets for abdominal aortic aneurysm treatment: evidence from recent preclinical research	16
Sjögren’s syndrome: shedding light on emerging and key drug targets	16
Feasibility of remnant cholesterol as a therapeutic target for atherosclerotic cardio-vascular disease	16
ULK1 as a therapeutic target in kidney diseases: Current perspective	16
Emerging therapeutic targets for anorexia nervosa	16
Myocarditis: causes, mechanisms, and evolving therapies	16
YAP1 signaling and cancer: molecular pathways reveal novel targeting opportunities	15
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update	15
Targeting acid-sensing ion channels in glioblastoma: is there any therapeutic potential?	15
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?	15
Granzyme B as a therapeutic target: an update in 2022	15
The Werner syndrome RECQ helicase as a therapeutic target: new insights	15
What is the potential of formyl peptide receptor 1 (FPR1) as a therapeutic target in human disease?	14
Mitochondria makeover: unlocking the path to healthy longevity	14
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer	14
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications	14
Molecular understanding for therapeutic targeting of hypoxia in breast cancer	13
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies	13
The contribution of fibronectin in epileptogenesis: therapeutic potential and mechanistic complexity	13
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?	13
AQP7 suppresses cell stemness and metastasis by targeting Wnt signaling in basal-like breast cancer	13
Metabolic hallmarks of trastuzumab resistance	13
XPO-1 targeting in chronic lymphocytic leukemia: is there potential for therapeutic strategy?	13
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression	12
The role of bile acid receptors in cholestatic liver disease: pathophysiological insights and therapeutic advances	12
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers	12
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	11
Leveraging AI to identify dual-purpose aging and disease targets	11

Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness	11
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential	11
Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level	11
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?	11
Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies	11
Rare tumors, real targets: patient-derived models for the discovery and validation of precision therapies	11
An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models	10
Cellular role of CD93 and its potential as a future therapeutic target	10
The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies	10
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2	10
Unveiling the role of mineralocorticoid receptor antagonists in epilepsy: the intersection of seizures, stress, and neuroinflammation	10
Molecular basis for targeting Caveolin-1 in multiple myeloma therapy	10
IGFBP-6 as a potential therapeutic target in musculoskeletal disorders	10
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment	10
FAM171A2 in Parkinson’s disease: mechanistic insights for a future therapeutic target	9
ORF6, a repressor of the MHC class I pathway: new molecular target for SARS-CoV-2 drug discovery?	9
Current strategies for targeting HPK1 in cancer and the barriers to preclinical progress	9
Targeting BUB1B-driven cancer stemness in lung adenocarcinoma: a novel therapeutic strategy via PI3K/AKT pathway modulation	9
Shedding light on emerging therapeutic targets for chordoma	9
Targeting the Tumor-Tumor Microenvironment Crosstalk	9
New therapeutic targets for endometrial cancer: a glimpse into the preclinical sphere	9
Ways of modulating GABA transporters to treat neurological disease	9
The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state	9
Targeting the TRPV1 pain pathway in osteoarthritis of the knee	9
Considerations on the implementation of MAP4K4 inhibitors as cancer treatment	9
The potential for OGG1 inhibition to be a therapeutic strategy for pulmonary diseases	9
The biological role of CCR4 and its ligands CCL17 and CCL22 in atopic dermatitis: therapeutic implications and future directions	9