OOIR: Observatory of International Research

Papers

(The TQCC of Expert Opinion on Therapeutic Targets is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines	121
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA	60
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects	56
Mitochondrial permeability transition pore: a snapshot of a therapeutic target	55
Targeting transcription in neuroblastoma: focus on the core regulatory circuit	45
CDK7 as a New therapeutic target in pancreatic and lung cancer: current evidence and future perspectives	40
Interleukin-18 in cancer immunology and immunotherapy	40
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy	39
IL-36: a therapeutic target for ulcerative colitis?	37
Glycoproteins and longevity: an interview with Professor Gordan Lauc	33
The membrane receptor CD44: roles in neurodegenerative diseases	33
Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications	33
Molecular basis for targeting TBK1 in CAR-T cell therapies for cancer	33
Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing	32
The sigma–1 receptor: a mechanistically–informed therapeutic target for antidepressants	32
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement	31
MDA-9/Syntenin as a therapeutic cancer metastasis target: current molecular and preclinical understanding	30
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer	30
The potential of multimolecular G-quadruplex structures for targeted treatment of Amyotrophic Lateral Sclerosis	28
Current challenges in the discovery of treatments against Mayaro fever	26
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets	25
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study	25
Identification of target sites in the VHR (DUSP3) enzyme unlocking potential avenues for future sepsis treatment	24
Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy	24
Uncovering key targets of success for immunotherapy in pancreatic cancer	23

Clostridioides difficile: innovations in target discovery and potential for therapeutic success	22
The challenges and potential of microRNA-based therapy for patients with liver failure syndromes and hepatocellular carcinoma	22
Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis	21
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath	20
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age	20
KRAS mutations in colorectal cancer: impacts on tumor microenvironment and therapeutic implications	20
The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?	19
Antibacterial carbonic anhydrase inhibitors targeting Vibrio cholerae enzymes	18
Esophageal cancer: emerging therapeutics	18
Novel signatures of prostate cancer progression and therapeutic resistance	18
The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin	18
The trap becomes the target: molecular basis for targeted inhibition of neutrophil extracellular traps in the pre-metastatic niche	18
Progeria: a perspective on potential drug targets and treatment strategies	18
Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABA_B R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model	18
Molecular pharmacology of multitarget cyclin-dependent kinase inhibitors in human colorectal carcinoma cells	17
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling	17
Promising therapeutic targets for the treatment of urine storage dysfunction: what’s the status?	17
RBM47 as a therapeutic target in selected human diseases	17
Targeting PRL phosphatases in hematological malignancies	17
ULK1 as a therapeutic target in kidney diseases: Current perspective	16
Myocarditis: causes, mechanisms, and evolving therapies	16
Tenosynovial giant cell tumors (TGCT): molecular biology, drug targets and non-surgical pharmacological approaches	16
What do we know about the renin angiotensin system and inflammatory bowel disease?	16
Targeting acid-sensing ion channels in glioblastoma: is there any therapeutic potential?	16
Atypical teratoid rhabdoid tumor (ATRT): disease mechanisms and potential drug targets	16
Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy	15
GDF15: a potential therapeutic target for type 1 diabetes	15
Sjögren’s syndrome: shedding light on emerging and key drug targets	15
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?	15
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update	15
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications	15
Emerging therapeutic targets for anorexia nervosa	15
Granzyme B as a therapeutic target: an update in 2022	15
What is the potential of formyl peptide receptor 1 (FPR1) as a therapeutic target in human disease?	14
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?	14
Mitochondria makeover: unlocking the path to healthy longevity	14
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers	13
Metabolic hallmarks of trastuzumab resistance	13
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer	13
The contribution of fibronectin in epileptogenesis: therapeutic potential and mechanistic complexity	13
The mechanisms and therapeutic targets of ferroptosis in cancer	13
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies	13
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression	12
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?	12
Rare tumors, real targets: patient-derived models for the discovery and validation of precision therapies	12
Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness	12
Unveiling the role of mineralocorticoid receptor antagonists in epilepsy: the intersection of seizures, stress, and neuroinflammation	12
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets	12
Leveraging AI to identify dual-purpose aging and disease targets	12
Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies	12

Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level	11
Cellular role of CD93 and its potential as a future therapeutic target	11
TAR DNA-binding protein of 43 kDa (TDP-43) and amyotrophic lateral sclerosis (ALS): a promising therapeutic target	11
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment	11
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential	11
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	11
Epigenetic regulatory mechanisms of histone acetylation in the treatment of cutaneous squamous cell carcinoma	11
Shedding light on emerging therapeutic targets for chordoma	11
The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state	11
The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies	11
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders	11
Emerging therapeutic targets for epilepsy: preclinical insights	11
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2	11
An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models	11