OOIR: Observatory of International Research

Papers

(The TQCC of Expert Opinion on Therapeutic Targets is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy	80
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects	57
CDK7 as a New therapeutic target in pancreatic and lung cancer: current evidence and future perspectives	46
Targeting transcription in neuroblastoma: focus on the core regulatory circuit	45
Interleukin-18 in cancer immunology and immunotherapy	44
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA	44
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines	39
IL-36: a therapeutic target for ulcerative colitis?	39
Mitochondrial permeability transition pore: a snapshot of a therapeutic target	38
Emergent RNA targets in cardiovascular disease: likely candidates for treatment development	38
P2 receptors as emerging therapeutic targets in neglected parasitic diseases	33
Glycoproteins and longevity: an interview with Professor Gordan Lauc	30
Molecular basis for targeting TBK1 in CAR-T cell therapies for cancer	28
The membrane receptor CD44: roles in neurodegenerative diseases	27
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement	26
The sigma–1 receptor: a mechanistically–informed therapeutic target for antidepressants	25
The potential of multimolecular G-quadruplex structures for targeted treatment of Amyotrophic Lateral Sclerosis	24
Identification of target sites in the VHR (DUSP3) enzyme unlocking potential avenues for future sepsis treatment	23
Blocking glycan production by targeting GALNT7 for prostate cancer therapy	22
The role of human complement factor H in retinal immune response and the prospects for targeted therapy for age-related macular degeneration (AMD)	22
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer	22
Advances in CGRP therapeutic targets for migraine: where do we stand 5 years later?	22
Current challenges in the discovery of treatments against Mayaro fever	22
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets	22
MDA-9/Syntenin as a therapeutic cancer metastasis target: current molecular and preclinical understanding	22

Bridging neurotransmission and tumor biology: the emerging focus on CHRM1 in skin cancer therapy	21
The challenges and potential of microRNA-based therapy for patients with liver failure syndromes and hepatocellular carcinoma	21
Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis	20
Antibacterial carbonic anhydrase inhibitors targeting Vibrio cholerae enzymes	20
Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy	20
The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin	20
Novel signatures of prostate cancer progression and therapeutic resistance	20
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age	20
KRAS mutations in colorectal cancer: impacts on tumor microenvironment and therapeutic implications	20
Molecular pharmacology of multitarget cyclin-dependent kinase inhibitors in human colorectal carcinoma cells	19
The trap becomes the target: molecular basis for targeted inhibition of neutrophil extracellular traps in the pre-metastatic niche	19
RBM47 as a therapeutic target in selected human diseases	18
Promising therapeutic targets for the treatment of urine storage dysfunction: what’s the status?	18
Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABA_B R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model	17
What do we know about the renin angiotensin system and inflammatory bowel disease?	17
Targeting PRL phosphatases in hematological malignancies	17
Lipopolysaccharide-targeting treatments for multidrug-resistant Pseudomonas aeruginosa	17
Novel therapeutic targets for abdominal aortic aneurysm treatment: evidence from recent preclinical research	17
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling	17
Granzyme B as a therapeutic target: an update in 2022	16
ULK1 as a therapeutic target in kidney diseases: Current perspective	16
Sjögren’s syndrome: shedding light on emerging and key drug targets	16
Feasibility of remnant cholesterol as a therapeutic target for atherosclerotic cardio-vascular disease	16
Myocarditis: causes, mechanisms, and evolving therapies	15
The Werner syndrome RECQ helicase as a therapeutic target: new insights	15
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?	15
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer	15
Emerging therapeutic targets for anorexia nervosa	15
Mitochondria makeover: unlocking the path to healthy longevity	15
What is the potential of formyl peptide receptor 1 (FPR1) as a therapeutic target in human disease?	15
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?	15
Targeting acid-sensing ion channels in glioblastoma: is there any therapeutic potential?	15
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update	15
YAP1 signaling and cancer: molecular pathways reveal novel targeting opportunities	15
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications	15
The contribution of fibronectin in epileptogenesis: therapeutic potential and mechanistic complexity	14
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers	14
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies	14
XPO-1 targeting in chronic lymphocytic leukemia: is there potential for therapeutic strategy?	14
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets	14
Metabolic hallmarks of trastuzumab resistance	14
AQP7 suppresses cell stemness and metastasis by targeting Wnt signaling in basal-like breast cancer	14
Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness	13
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression	13
Rare tumors, real targets: patient-derived models for the discovery and validation of precision therapies	13
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?	13
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	13
Molecular understanding for therapeutic targeting of hypoxia in breast cancer	13
Unveiling the role of mineralocorticoid receptor antagonists in epilepsy: the intersection of seizures, stress, and neuroinflammation	12
Leveraging AI to identify dual-purpose aging and disease targets	12

Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies	12
Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level	12
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders	11
IGFBP-6 as a potential therapeutic target in musculoskeletal disorders	11
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment	11
Cellular role of CD93 and its potential as a future therapeutic target	11
Shedding light on emerging therapeutic targets for chordoma	11
An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models	11
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential	11
Molecular basis for targeting Caveolin-1 in multiple myeloma therapy	11
FAM171A2 in Parkinson’s disease: mechanistic insights for a future therapeutic target	11
Considerations on the implementation of MAP4K4 inhibitors as cancer treatment	10
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2	10
The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state	10
ORF6, a repressor of the MHC class I pathway: new molecular target for SARS-CoV-2 drug discovery?	10
The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies	10
New therapeutic targets for endometrial cancer: a glimpse into the preclinical sphere	10
TAR DNA-binding protein of 43 kDa (TDP-43) and amyotrophic lateral sclerosis (ALS): a promising therapeutic target	10