Expert Opinion on Therapeutic Targets

Papers
(The TQCC of Expert Opinion on Therapeutic Targets is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines102
lncRNAs: potential therapeutic targets and biomarkers for pancreatic cancer?56
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy52
Mitochondrial permeability transition pore: a snapshot of a therapeutic target45
IL-36: a therapeutic target for ulcerative colitis?37
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects36
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA35
Interleukin-18 in cancer immunology and immunotherapy35
NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): seven years between lights and shadows33
Axial spondyloarthritis: emerging drug targets33
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement30
Aberrations of DNA repair pathways in prostate cancer: a cornerstone of precision oncology30
Glycoproteins and longevity: an interview with Professor Gordan Lauc30
Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications29
Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing28
The sigma-1 receptor: a mechanistically-informed therapeutic target for antidepressants26
MDA-9/Syntenin as a therapeutic cancer metastasis target: current molecular and preclinical understanding25
Current challenges in the discovery of treatments against Mayaro fever25
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets25
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer24
A short report on NGM282/aldafermin for the treatment of nonalcoholic steatohepatitis (NASH)24
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study23
The potential of multimolecular G-quadruplex structures for targeted treatment of Amyotrophic Lateral Sclerosis23
Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy23
Clostridioides difficile: innovations in target discovery and potential for therapeutic success23
The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?22
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age22
Novel signatures of prostate cancer progression and therapeutic resistance22
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath22
Antibacterial carbonic anhydrase inhibitors targeting Vibrio cholerae enzymes21
The challenges and potential of microRNA-based therapy for patients with liver failure syndromes and hepatocellular carcinoma21
Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis20
Esophageal cancer: emerging therapeutics20
Uncovering key targets of success for immunotherapy in pancreatic cancer20
What do we know about the renin angiotensin system and inflammatory bowel disease?19
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling19
The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin19
Progeria: a perspective on potential drug targets and treatment strategies18
Molecular pharmacology of multitarget cyclin-dependent kinase inhibitors in human colorectal carcinoma cells18
Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABAB R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model17
Tenosynovial giant cell tumors (TGCT): molecular biology, drug targets and non-surgical pharmacological approaches16
Targeting PRL phosphatases in hematological malignancies16
Hepatocellular carcinoma (HCC): the most promising therapeutic targets in the preclinical arena based on tumor biology characteristics15
Targeting acid-sensing ion channels in glioblastoma: is there any therapeutic potential?15
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)15
Promising therapeutic targets for the treatment of urine storage dysfunction: what’s the status?15
Myocarditis: causes, mechanisms, and evolving therapies14
Sjögren’s syndrome: shedding light on emerging and key drug targets14
Atypical teratoid rhabdoid tumor (ATRT): disease mechanisms and potential drug targets14
ULK1 as a therapeutic target in kidney diseases: Current perspective14
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update14
Granzyme B as a therapeutic target: an update in 202214
Emerging therapeutic targets for anorexia nervosa14
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?13
GDF15: a potential therapeutic target for type 1 diabetes13
Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy13
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications13
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets12
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?12
Mitochondria makeover: unlocking the path to healthy longevity12
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer12
Hypoplastic left heart syndrome (HLHS): molecular pathogenesis and emerging drug targets for cardiac repair and regeneration12
Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential12
Retinal vein occlusion: drug targets and therapeutic implications12
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers11
NTRK fusions in colorectal cancer: clinical meaning and future perspective11
The mechanisms and therapeutic targets of ferroptosis in cancer11
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?11
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression11
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies11
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders10
Leveraging AI to identify dual-purpose aging and disease targets10
Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level10
Neuromodulatory effects of SARS-CoV2 infection: Possible therapeutic targets10
Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies10
Epigenetic regulatory mechanisms of histone acetylation in the treatment of cutaneous squamous cell carcinoma10
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential10
Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness10
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses10
Tackling retinal ganglion cell apoptosis in glaucoma: role of adenosine receptors10
Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations10
Emerging therapeutic targets for epilepsy: preclinical insights9
The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies9
ORF6, a repressor of the MHC class I pathway: new molecular target for SARS-CoV-2 drug discovery?9
Influence of the inflammasome complex on psychiatric disorders: clinical and preclinical studies9
Tumor-associated neutrophils: orchestrating cancer pathobiology and therapeutic resistance9
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-29
Ways of modulating GABA transporters to treat neurological disease9
Shedding light on emerging therapeutic targets for chordoma9
An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models9
The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state9
Current strategies for targeting HPK1 in cancer and the barriers to preclinical progress9
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment9
Cellular role of CD93 and its potential as a future therapeutic target9
TAR DNA-binding protein of 43 kDa (TDP-43) and amyotrophic lateral sclerosis (ALS): a promising therapeutic target9
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