OOIR: Observatory of International Research

Papers

(The TQCC of Expert Opinion on Therapeutic Targets is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Esophageal cancer: emerging therapeutics	77
Aberrations of DNA repair pathways in prostate cancer: a cornerstone of precision oncology	47
Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease	41
Omentin-1: a newly discovered warrior against metabolic related diseases	39
TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2	37
CCR5 is a potential therapeutic target for cancer	35
HSP47: a potential target for fibrotic diseases and implications for therapy	35
PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date	33
Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations	28
Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy	27
Microglia as therapeutic targets after neurological injury: strategy for cell therapy	26
The mechanisms and therapeutic targets of ferroptosis in cancer	26
Calpain as a therapeutic target in cancer	25
Systemic lupus erythematosus (SLE): emerging therapeutic targets	25
Is neurotrophin-3 (NT-3): a potential therapeutic target for depression and anxiety?	25
The gut microbiome as a target for adjuvant therapy in obstructive sleep apnea	25
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases	24
MET alterations and their impact on the future of non-small cell lung cancer (NSCLC) targeted therapies	24
The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer’s	24
Tumor-associated neutrophils: orchestrating cancer pathobiology and therapeutic resistance	23
An overview of novel antimicrobial carbonic anhydrase inhibitors	23
Liver X receptor: a potential target in the treatment of atherosclerosis	23
Therapeutic application of GLP-1 and GIP receptor agonists in Parkinson’s disease	21
Redox-sensitive TRP channels: a promising pharmacological target in chemotherapy-induced peripheral neuropathy	21
Targeting Fc effector function in vaccine design	20

Emerging therapeutic targets for cerebral edema	20
CD36 as a target for metabolic modulation therapy in cardiac disease	19
Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability	19
TAM kinase inhibition and immune checkpoint blockade– a winning combination in cancer treatment?	18
Autoimmune encephalitis: novel therapeutic targets at the preclinical level	18
Endothelial dysfunction: a therapeutic target in bacterial sepsis?	18
Non-histone substrates of histone deacetylases as potential therapeutic targets in epilepsy	18
Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity	18
Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases	18
Targeting RUNX1 in acute myeloid leukemia: preclinical innovations and therapeutic implications	18
Epigenetic regulation in Alzheimer’s disease: is it a potential therapeutic target?	17
Disease progression pathways of wet AMD: opportunities for new target discovery	17
Nrf2 as a therapeutic target in ischemic stroke	17
Potassium channels as prominent targets and tools for the treatment of epilepsy	17
Targeting TIM-3 in solid tumors: innovations in the preclinical and translational realm and therapeutic potential	17
Novel immune targets for the treatment of triple-negative breast cancer	16
Targeting the EGFR signaling pathway in cancer therapy: What’s new in 2023?	16
Emerging therapeutic targets for cardiac hypertrophy	16
Emerging therapeutic targets for schizophrenia: a framework for novel treatment strategies for psychosis	16
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)	15
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study	15
GDF15: a potential therapeutic target for type 1 diabetes	15
The potential for immune checkpoint modulators in cerebrovascular injury and inflammation	15
The CB2 cannabinoid receptor as a therapeutic target in the central nervous system	14
Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway	14
Transglutaminase 2 as a therapeutic target for neurological conditions	14
Emerging therapeutic targets for sepsis	14
A vasculature-centric approach to developing novel treatment options for glioblastoma	14
Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles	14
The role of immune response in the pathogenesis of idiopathic pulmonary fibrosis: far beyond the Th1/Th2 imbalance	14
Renal fibrosis as a hallmark of diabetic kidney disease: potential role of targeting transforming growth factor-beta (TGF-β) and related molecules	14
The Nrf2 pathway in psychiatric disorders: pathophysiological role and potential targeting	13
Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) – the involvement of mitochondrial quality control, autophagy, and antioxidant response	13
OXPHOS-targeting drugs in oncology: new perspectives	13
Emerging therapeutic targets for gastric cancer from a host-Helicobacter pylori interaction perspective	13
Fatty acid synthase: a druggable driver of breast cancer brain metastasis	12
Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging	12
Targeting the tumor microenvironment in cholangiocarcinoma: implications for therapy	12
Targeting SHP2 phosphatase in hematological malignancies	12
The α9α10 nicotinic acetylcholine receptor: a compelling drug target for hearing loss?	11
Glutamatergic dysregulation in mood disorders: opportunities for the discovery of novel drug targets	11
Riboswitches as therapeutic targets: promise of a new era of antibiotics	11
NTRK fusions in colorectal cancer: clinical meaning and future perspective	11
TROP2 (trophoblast cell-surface antigen 2): a drug target for breast cancer	11
Peripheral vascular disease: preclinical models and emerging therapeutic targeting of the vascular endothelial growth factor ligand-receptor system	11
Emerging therapeutic targets for osteoarthritis	11
Beyond basic research: the contribution of cathepsin B to cancer development, diagnosis and therapy	10
Bromodomain-containing protein 4 (BRD4): a key player in inflammatory bowel disease and potential to inspire epigenetic therapeutics	10
Tenosynovial giant cell tumors (TGCT): molecular biology, drug targets and non-surgical pharmacological approaches	10
Emerging role for the Serum Response Factor (SRF) as a potential therapeutic target in cancer	9

Targeting the Tumor-Tumor Microenvironment Crosstalk	9
Taking the road less traveled – the therapeutic potential of CBP/β-catenin antagonists	9
Leucine-rich repeat kinase 2 (LRRK2): an update on the potential therapeutic target for Parkinson’s disease	9
Enteroviruses and coronaviruses: similarities and therapeutic targets	9
Dapagliflozin mitigates ovalbumin-prompted airway inflammatory-oxidative successions and associated bronchospasm in a rat model of allergic asthma	9
Glycometabolic rearrangements–aerobic glycolysis in pancreatic ductal adenocarcinoma (PDAC): roles, regulatory networks, and therapeutic potential	9
Retinal vein occlusion: drug targets and therapeutic implications	9
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models	9
Emerging therapeutic targets for cardiac arrhythmias: role of STAT3 in regulating cardiac fibroblast function	9
Cholangiocarcinoma: what are the most valuable therapeutic targets – cancer-associated fibroblasts, immune cells, or beyond T cells?	9
Early clinical and pre-clinical therapy development in Nemaline myopathy	8
Hypoplastic left heart syndrome (HLHS): molecular pathogenesis and emerging drug targets for cardiac repair and regeneration	8
Airway smooth muscle in contractility and remodeling of asthma: potential drug target mechanisms	8
Targeting calcium-mediated inter-organellar crosstalk in cardiac diseases	8
Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential	8
Targeting fetal hemoglobin expression to treat β hemoglobinopathies	8
Modulations of ferroptosis in lung cancer therapy	8
Casein Kinase II exacerbates rheumatoid arthritis via promoting Th1 and Th17 cell inflammatory responses	8
Veliparib (ABT-888), a PARP inhibitor potentiates the cytotoxic activity of 5-fluorouracil by inhibiting MMR pathway through deregulation of MSH6 in colorectal cancer stem cells	8
Defibrotide: potential for treating endothelial dysfunction related to viral and post-infectious syndromes	8
Uncovering key targets of success for immunotherapy in pancreatic cancer	8
Human prion disease: molecular pathogenesis, and possible therapeutic targets and strategies	8
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	8
Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets	8
Targeting neuroprotective functions of astrocytes in neuroimmune diseases	8
Glycans: potential therapeutic targets for cholangiocarcinoma and their therapeutic and diagnostic implications	8
NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): seven years between lights and shadows	8
Parasite and host kinases as targets for antimalarials	8