OOIR: Observatory of International Research

Papers

(The TQCC of Expert Opinion on Therapeutic Targets is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy	112
Mitochondrial permeability transition pore: a snapshot of a therapeutic target	56
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA	50
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects	41
Interleukin-18 in cancer immunology and immunotherapy	41
IL-36: a therapeutic target for ulcerative colitis?	37
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines	36
The sigma–1 receptor: a mechanistically–informed therapeutic target for antidepressants	35
Glycoproteins and longevity: an interview with Professor Gordan Lauc	32
Axial spondyloarthritis: emerging drug targets	32
Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications	31
Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing	30
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement	30
NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): seven years between lights and shadows	29
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer	28
MDA-9/Syntenin as a therapeutic cancer metastasis target: current molecular and preclinical understanding	27
Current challenges in the discovery of treatments against Mayaro fever	26
A short report on NGM282/aldafermin for the treatment of nonalcoholic steatohepatitis (NASH)	26
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study	25
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets	25
The potential of multimolecular G-quadruplex structures for targeted treatment of Amyotrophic Lateral Sclerosis	25
Clostridioides difficile: innovations in target discovery and potential for therapeutic success	24
Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy	24
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age	22
The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?	21

Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis	21
Antibacterial carbonic anhydrase inhibitors targeting Vibrio cholerae enzymes	21
Uncovering key targets of success for immunotherapy in pancreatic cancer	21
KRAS mutations in colorectal cancer: impacts on tumor microenvironment and therapeutic implications	21
Novel signatures of prostate cancer progression and therapeutic resistance	20
The challenges and potential of microRNA-based therapy for patients with liver failure syndromes and hepatocellular carcinoma	20
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath	20
Esophageal cancer: emerging therapeutics	19
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling	19
Tenosynovial giant cell tumors (TGCT): molecular biology, drug targets and non-surgical pharmacological approaches	18
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)	18
Hepatocellular carcinoma (HCC): the most promising therapeutic targets in the preclinical arena based on tumor biology characteristics	17
Progeria: a perspective on potential drug targets and treatment strategies	17
Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABA_B R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model	16
What do we know about the renin angiotensin system and inflammatory bowel disease?	16
The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin	16
Targeting PRL phosphatases in hematological malignancies	16
The trap becomes the target: molecular basis for targeted inhibition of neutrophil extracellular traps in the pre-metastatic niche	16
ULK1 as a therapeutic target in kidney diseases: Current perspective	15
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update	15
Molecular pharmacology of multitarget cyclin-dependent kinase inhibitors in human colorectal carcinoma cells	15
Promising therapeutic targets for the treatment of urine storage dysfunction: what’s the status?	15
Targeting acid-sensing ion channels in glioblastoma: is there any therapeutic potential?	15
Atypical teratoid rhabdoid tumor (ATRT): disease mechanisms and potential drug targets	15
Myocarditis: causes, mechanisms, and evolving therapies	14
GDF15: a potential therapeutic target for type 1 diabetes	14
Sjögren’s syndrome: shedding light on emerging and key drug targets	14
Emerging therapeutic targets for anorexia nervosa	14
Granzyme B as a therapeutic target: an update in 2022	14
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?	13
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications	13
Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy	13
Retinal vein occlusion: drug targets and therapeutic implications	13
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?	13
What is the potential of formyl peptide receptor 1 (FPR1) as a therapeutic target in human disease?	13
Mitochondria makeover: unlocking the path to healthy longevity	12
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression	12
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?	12
Epigenetic regulatory mechanisms of histone acetylation in the treatment of cutaneous squamous cell carcinoma	12
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers	12
The mechanisms and therapeutic targets of ferroptosis in cancer	12
Hypoplastic left heart syndrome (HLHS): molecular pathogenesis and emerging drug targets for cardiac repair and regeneration	12
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies	12
Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies	12
Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness	12
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer	12
Metabolic hallmarks of trastuzumab resistance	12
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets	12
Leveraging AI to identify dual-purpose aging and disease targets	12
NTRK fusions in colorectal cancer: clinical meaning and future perspective	12

Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	11
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential	11
The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies	11
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders	11
Emerging therapeutic targets for epilepsy: preclinical insights	11
Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level	11
An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models	11
Influence of the inflammasome complex on psychiatric disorders: clinical and preclinical studies	11
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment	10
Ways of modulating GABA transporters to treat neurological disease	10
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2	10
Considerations on the implementation of MAP4K4 inhibitors as cancer treatment	10
ORF6, a repressor of the MHC class I pathway: new molecular target for SARS-CoV-2 drug discovery?	10
TAR DNA-binding protein of 43 kDa (TDP-43) and amyotrophic lateral sclerosis (ALS): a promising therapeutic target	10
The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state	10
Medulloblastoma: novel insights into emerging therapeutic targets	10
Shedding light on emerging therapeutic targets for chordoma	10
Cellular role of CD93 and its potential as a future therapeutic target	10