Expert Opinion on Therapeutic Targets

Article	Citations
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy	80
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects	57
CDK7 as a New therapeutic target in pancreatic and lung cancer: current evidence and future perspectives	46
Targeting transcription in neuroblastoma: focus on the core regulatory circuit	45
Interleukin-18 in cancer immunology and immunotherapy	44
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA	44
IL-36: a therapeutic target for ulcerative colitis?	39
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines	39
Mitochondrial permeability transition pore: a snapshot of a therapeutic target	38
Emergent RNA targets in cardiovascular disease: likely candidates for treatment development	38
P2 receptors as emerging therapeutic targets in neglected parasitic diseases	33
Glycoproteins and longevity: an interview with Professor Gordan Lauc	30
Molecular basis for targeting TBK1 in CAR-T cell therapies for cancer	28
The membrane receptor CD44: roles in neurodegenerative diseases	27
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement	26
The sigma–1 receptor: a mechanistically–informed therapeutic target for antidepressants	25
The potential of multimolecular G-quadruplex structures for targeted treatment of Amyotrophic Lateral Sclerosis	24
Identification of target sites in the VHR (DUSP3) enzyme unlocking potential avenues for future sepsis treatment	23
Blocking glycan production by targeting GALNT7 for prostate cancer therapy	22
The role of human complement factor H in retinal immune response and the prospects for targeted therapy for age-related macular degeneration (AMD)	22
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer	22
Advances in CGRP therapeutic targets for migraine: where do we stand 5 years later?	22
Current challenges in the discovery of treatments against Mayaro fever	22
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets	22
MDA-9/Syntenin as a therapeutic cancer metastasis target: current molecular and preclinical understanding	22

Bridging neurotransmission and tumor biology: the emerging focus on CHRM1 in skin cancer therapy	21
The challenges and potential of microRNA-based therapy for patients with liver failure syndromes and hepatocellular carcinoma	21
Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy	20
The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin	20
Novel signatures of prostate cancer progression and therapeutic resistance	20
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age	20
KRAS mutations in colorectal cancer: impacts on tumor microenvironment and therapeutic implications	20
Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis	20
Antibacterial carbonic anhydrase inhibitors targeting Vibrio cholerae enzymes	20
The trap becomes the target: molecular basis for targeted inhibition of neutrophil extracellular traps in the pre-metastatic niche	19
Molecular pharmacology of multitarget cyclin-dependent kinase inhibitors in human colorectal carcinoma cells	19
RBM47 as a therapeutic target in selected human diseases	18
Promising therapeutic targets for the treatment of urine storage dysfunction: what’s the status?	18
What do we know about the renin angiotensin system and inflammatory bowel disease?	17
Targeting PRL phosphatases in hematological malignancies	17
Lipopolysaccharide-targeting treatments for multidrug-resistant Pseudomonas aeruginosa	17
Novel therapeutic targets for abdominal aortic aneurysm treatment: evidence from recent preclinical research	17
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling	17
Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABAB R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model	17
Granzyme B as a therapeutic target: an update in 2022	16
ULK1 as a therapeutic target in kidney diseases: Current perspective	16
Sjögren’s syndrome: shedding light on emerging and key drug targets	16
Feasibility of remnant cholesterol as a therapeutic target for atherosclerotic cardio-vascular disease	16
Myocarditis: causes, mechanisms, and evolving therapies	15
The Werner syndrome RECQ helicase as a therapeutic target: new insights	15
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?	15
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer	15
Emerging therapeutic targets for anorexia nervosa	15
Mitochondria makeover: unlocking the path to healthy longevity	15
What is the potential of formyl peptide receptor 1 (FPR1) as a therapeutic target in human disease?	15
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?	15
Targeting acid-sensing ion channels in glioblastoma: is there any therapeutic potential?	15
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update	15
YAP1 signaling and cancer: molecular pathways reveal novel targeting opportunities	15
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications	15
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies	14
XPO-1 targeting in chronic lymphocytic leukemia: is there potential for therapeutic strategy?	14
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets	14
Metabolic hallmarks of trastuzumab resistance	14
AQP7 suppresses cell stemness and metastasis by targeting Wnt signaling in basal-like breast cancer	14
The contribution of fibronectin in epileptogenesis: therapeutic potential and mechanistic complexity	14
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers	14
Rare tumors, real targets: patient-derived models for the discovery and validation of precision therapies	13
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?	13
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	13
Molecular understanding for therapeutic targeting of hypoxia in breast cancer	13
Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness	13
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression	13
Unveiling the role of mineralocorticoid receptor antagonists in epilepsy: the intersection of seizures, stress, and neuroinflammation	12
Leveraging AI to identify dual-purpose aging and disease targets	12

Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies	12
Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level	12
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders	11
IGFBP-6 as a potential therapeutic target in musculoskeletal disorders	11
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment	11
Cellular role of CD93 and its potential as a future therapeutic target	11
Shedding light on emerging therapeutic targets for chordoma	11
An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models	11
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential	11
Molecular basis for targeting Caveolin-1 in multiple myeloma therapy	11
FAM171A2 in Parkinson’s disease: mechanistic insights for a future therapeutic target	11
ORF6, a repressor of the MHC class I pathway: new molecular target for SARS-CoV-2 drug discovery?	10
The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state	10
New therapeutic targets for endometrial cancer: a glimpse into the preclinical sphere	10
TAR DNA-binding protein of 43 kDa (TDP-43) and amyotrophic lateral sclerosis (ALS): a promising therapeutic target	10
The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies	10
Considerations on the implementation of MAP4K4 inhibitors as cancer treatment	10
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2	10
Targeting the TRPV1 pain pathway in osteoarthritis of the knee	9
Ways of modulating GABA transporters to treat neurological disease	9
Emerging pathways yielding opportunities for future treatments in pancreatic ductal adenocarcinoma	9
Current strategies for targeting HPK1 in cancer and the barriers to preclinical progress	9
Cardiac conduction diseases: understanding the molecular mechanisms to uncover targets for future treatments	9
Role of the P2Y12 receptor on thrombus formation and evolution in therapeutic strategies	9
Targeting BUB1B-driven cancer stemness in lung adenocarcinoma: a novel therapeutic strategy via PI3K/AKT pathway modulation	9
Targeting the Tumor-Tumor Microenvironment Crosstalk	9
The emerging role of TIM-3 in colorectal cancer: a promising target for immunotherapy	9
aMMP-8 point-of-care - diagnostic methods and treatment modalities in periodontitis and peri-implantitis	9
The emerging role of Tetraspanin 32 in autoimmune diseases: from discovery to relevant theranostics?	8
The potential for OGG1 inhibition to be a therapeutic strategy for pulmonary diseases	8
Gateway reflexes are neural circuits that establish the gateway of immune cells to regulate tissue specific inflammation	8
Restoring FXR expression as a novel treatment strategy in liver cancer and other liver disorders	8
An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection	8
Acute myeloid leukemia: therapeutic targeting of stem cells	8
TROP2 (trophoblast cell-surface antigen 2): a drug target for breast cancer	8
A two-decade journey in identifying high mobility group box 1 (HMGB1) and procathepsin L (pCTS-L) as potential therapeutic targets for sepsis	8
Renal fibrosis as a hallmark of diabetic kidney disease: potential role of targeting transforming growth factor-beta (TGF-β) and related molecules	8
Therapeutic potential for glial-derived octadecaneuropeptide in the treatment of obesity	8
The molecular role of RE1 silencing transcription factor in uterine diseases: is there potential for targeted therapeutic development?	7
Fatty acid-mediated signaling as a target for developing type 1 diabetes therapies	7
Targeting mucosal healing in Crohn’s disease: efficacy of novel pathways and therapeutic targets	7
Repurposing fluoxetine to treat lymphocytic leukemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction	7
Fatty liver disease: time to target CCR5?	7
Can targeting the FGF23-αKlotho signaling system delay phosphate-driven organ damage?	7
NRG/ErbB signaling: on the trail of a molecular fingerprint in mucinous carcinoma	7
Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets	7
Renal ciliopathies: promising drug targets and prospects for clinical trials	7
Pharmacological targeting of ECM homeostasis, fibroblast activation and invasion for the treatment of pulmonary fibrosis	7
Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors?	7
Assessing the current molecular understanding of therapeutic targets in osteosarcoma	7
Arenobufagin induces cell apoptosis by modulating the cell cycle regulator claspin and the JNK pathway in nasopharyngeal carcinoma cells	7
Tumor cells-derived extracellular vesicles carry circ_0064516 competitively inhibit microRNA-6805-3p and promote cervical cancer angiogenesis and tumor growth	7
The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review	7
Intrinsically disordered AF1 domain of steroid hormone receptors as a novel potential target for endocrine cancers	7
Epigenetic regulation of immune cells in systemic lupus erythematosus: insight from chromatin accessibility	6
Modulating multidrug resistance to drug-based antitumor therapies through NF-κB signaling pathway: mechanisms and perspectives	6
Potential therapeutic targets and biomarkers in testicular germ cell tumor oncogenesis	6
Enhancer of zeste homolog 2 (EZH2) in endocrine tumors: current knowledge and future directions	6
Investigating metabotropic glutamate receptors as molecular targets for next-generation pharmacotherapies for alcohol use disorder	6
Kv1.3 in the spotlight for treating immune diseases	6
Cytokines of the interleukin-6 family as emerging targets in inflammatory bowel disease	6
Sirtuins as therapeutic targets in diabetes	6
MT1-MMP – A potential drug target for the management of the obesity	6
Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?	6
TGF-β as a therapeutic target in the infarcted and failing heart: cellular mechanisms, challenges, and opportunities	6
Focusing on oligomeric tau as a therapeutic target in Alzheimer’s disease and other tauopathies	6
Exploring PKG signaling as a therapeutic avenue for pressure overload, ischemia, and HFpEF	6
MicroRNA-96 inhibition retarded the progression of atherosclerotic plaques via FOXO1/CYP7A1 mediated cholesterol-bile acid metabolism pathway	6
Unlocking the potential of melanotransferrin (CD228): implications for targeted drug development and novel therapeutic avenues	6
XBP1 as a novel molecular target to attenuate drug resistance in hepatocellular carcinoma	6
Understanding how bacterial cell wall peptidoglycan metabolism can be used to develop antimicrobial strategies	6
Toxoplasma gondii infection: novel emerging therapeutic targets	6
Autophagic failure with age: influence on metabolic disorders and prospects for therapeutic targeting	6
Modulating tonic NMDA receptor currents: mechanistic insights into ketamine, esketamine, and dextromethorphan for major depressive disorder and implications for the discovery and development of invest	6
GADD45: a crucial component of the DNA damage response and a potential cancer therapeutic target	6
Hide and seek: targeting nuclear receptor PXR with inhibitors and PROTACs to improve drug efficacy and safety	6
Paraspeckle component 1 in acute myeloid leukemia: prospects for therapeutic targeting	5
RNA-centric approaches in amyotrophic lateral sclerosis: prospects for future therapeutics	5
Lipocalin-2 as a therapeutic target for diabetes neurological complications	5
Novel chromobox 2 inhibitory peptide decreases tumor progression	5

High levels of HDAC expression correlate with microglial aging	5
Identifying targets at the blood-brain barrier for treating vascular cognitive impairment and dementia	5
Cataract-related mutations in EphA2: a survey of literature data and the relevance of the receptor Sam domain	5
Correction	5
The participation of non-canonical autophagic proteins in the autophagy process and their potential as therapeutic targets	5
miR-181a : regulatory roles, cancer-associated signaling pathway disruptions, and therapeutic potential	5
Potential molecular targets for the pharmacologic management of non-traumatic osteonecrosis	5
Airway smooth muscle in contractility and remodeling of asthma: potential drug target mechanisms	5
Sugars to signals: emerging roles of PAK1 in re-wiring glucose metabolism in cancers	5
Targeting GABA receptors with chalcone derivative compounds, what is the evidence?	5
Epigenetic determinants in soft tissue sarcomas: molecular mechanisms and therapeutic targets	5
HIV Pol: does it offer therapeutic targets for HIV?	5
Therapeutic targets for pulmonary arterial hypertension: insights into the emerging landscape	5
Uncovering immune pathways for therapeutic targeting of hypertension	5
The molecular mechanisms and targeting strategies of transcription factors in cholangiocarcinoma	5
Advancing our understanding of molecular targets for hepatic ischemia-reperfusion injury therapy	5
The role of ubiquitination in microbial infection induced endothelial dysfunction: potential therapeutic targets for sepsis	5
CDK6: an attractive therapeutic target for T-ALL/LBL	5
Type 1 diabetes: key drug targets and how they could influence future therapeutics	5
Feasibility and considerations of epsin2 as a candidate target for multiple system atrophy treatment	5
Therapeutic perspectives on PDE4B inhibition in adipose tissue dysfunction and chronic liver injury	5
SCN1A as a therapeutic target for Dravet syndrome	5
Targeting endoplasmic reticulum stress—the responder to lipotoxicity and modulator of non-alcoholic fatty liver diseases	5
Candidate molecular targets uncovered in mouse lifespan extension studies	5