Expert Opinion on Therapeutic Targets

Article	Citations
Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma	105
TGF-beta: a master immune regulator	99
TRPA1 as a therapeutic target for nociceptive pain	92
The cytokine storm of COVID-19: a spotlight on prevention and protection	75
Therapeutic antibodies and fusion inhibitors targeting the spike protein of SARS-CoV-2	49
Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS)	49
Esophageal cancer: emerging therapeutics	49
Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatment	44
Cancer associated fibroblasts: role in breast cancer and potential as therapeutic targets	42
Alzheimer’s disease: microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation	42
New therapeutic targets in chronic kidney disease progression and renal fibrosis	40
Aberrations of DNA repair pathways in prostate cancer: a cornerstone of precision oncology	38
Glioblastoma multiforme: novel therapeutic targets	34
TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2	33
Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease	33
Targeting TLR4-dependent inflammation in post-hemorrhagic brain injury	32
The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma	32
Nutritional intervention in chronic pain: an innovative way of targeting central nervous system sensitization?	31
Omentin-1: a newly discovered warrior against metabolic related diseases	30
HSP47: a potential target for fibrotic diseases and implications for therapy	29
CCR5 is a potential therapeutic target for cancer	27
Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain	27
Duodenal inflammation: an emerging target for functional dyspepsia?	27
Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy	26
The role of microRNA in cisplatin resistance or sensitivity	26

ERAP1: a potential therapeutic target for a myriad of diseases	25
Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness	25
Glycogen synthase kinase-3β: a novel therapeutic target for pancreatic cancer	25
FGF2: a novel druggable target for glioblastoma?	24
Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations	24
Cysteine cathepsins as therapeutic targets in inflammatory diseases	23
Emerging therapeutic targets for neuromyelitis optica spectrum disorder	23
Targeting TANK-binding kinase 1 (TBK1) in cancer	23
Microglia as therapeutic targets after neurological injury: strategy for cell therapy	22
MET alterations and their impact on the future of non-small cell lung cancer (NSCLC) targeted therapies	22
Systemic lupus erythematosus (SLE): emerging therapeutic targets	22
PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date	21
The gut microbiome as a target for adjuvant therapy in obstructive sleep apnea	21
Sirtuins: potential therapeutic targets for regulating acute inflammatory response?	21
Activin A: an emerging target for improving cancer treatment?	20
Is neurotrophin-3 (NT-3): a potential therapeutic target for depression and anxiety?	20
Myeloperoxidase: a potential therapeutic target for coronary artery disease	20
Tumor-associated neutrophils: orchestrating cancer pathobiology and therapeutic resistance	20
Liver X receptor: a potential target in the treatment of atherosclerosis	20
Targeting p53 in chronic lymphocytic leukemia	19
The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer’s	19
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases	18
The mechanisms and therapeutic targets of ferroptosis in cancer	18
Alzheimer’s disease: phenotypic approaches using disease models and the targeting of tau protein	17
Autoimmune encephalitis: novel therapeutic targets at the preclinical level	17
TAM kinase inhibition and immune checkpoint blockade– a winning combination in cancer treatment?	17
Nrf2 as a therapeutic target in ischemic stroke	17
Targeting Fc effector function in vaccine design	17
CD36 as a target for metabolic modulation therapy in cardiac disease	17
The BAFF / APRIL system as therapeutic target in multiple sclerosis	16
The interaction between microbiome and host central nervous system: the gut-brain axis as a potential new therapeutic target in the treatment of obesity and cardiometabolic disease	16
Targeting TIM-3 in solid tumors: innovations in the preclinical and translational realm and therapeutic potential	16
Calpain as a therapeutic target in cancer	15
Emerging therapeutic targets for cerebral edema	15
Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability	15
Redox-sensitive TRP channels: a promising pharmacological target in chemotherapy-induced peripheral neuropathy	15
Targeting RUNX1 in acute myeloid leukemia: preclinical innovations and therapeutic implications	15
RNA in spinal muscular atrophy: therapeutic implications of targeting	15
Therapeutic application of GLP-1 and GIP receptor agonists in Parkinson’s disease	15
Epigenetic regulation in Alzheimer’s disease: is it a potential therapeutic target?	14
Emerging therapeutic targets for schizophrenia: a framework for novel treatment strategies for psychosis	14
Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles	13
Non-histone substrates of histone deacetylases as potential therapeutic targets in epilepsy	13
Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway	13
The necroptosis pathway and its role in age-related neurodegenerative diseases: will it open up new therapeutic avenues in the next decade?	13
Emerging therapeutic targets for cardiac hypertrophy	13
Mechanisms underlying priapism in sickle cell disease: targeting and key innovations on the preclinical landscape	13
An expert update on novel therapeutic targets for hyperphosphatemia in chronic kidney disease: preclinical and clinical innovations	13
Potassium channels as prominent targets and tools for the treatment of epilepsy	13
Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity	13

The potential for immune checkpoint modulators in cerebrovascular injury and inflammation	13
Emerging therapeutic targets for neuroblastoma	13
Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) – the involvement of mitochondrial quality control, autophagy, and antioxidant response	12
Cepharanthine hydrochloride induces mitophagy targeting GPR30 in hepatocellular carcinoma (HCC)	12
GDF15: a potential therapeutic target for type 1 diabetes	12
Fumarate hydratase as a therapeutic target in renal cancer	12
Emerging therapeutic targets for gastric cancer from a host-Helicobacter pylori interaction perspective	12
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study	12
The bone marrow stromal niche: a therapeutic target of hematological myeloid malignancies	11
Endothelial dysfunction: a therapeutic target in bacterial sepsis?	11
Renal fibrosis as a hallmark of diabetic kidney disease: potential role of targeting transforming growth factor-beta (TGF-β) and related molecules	11
Emerging therapeutic targets for sepsis	11
The ceramide-S1P pathway as a druggable target to alleviate peripheral neuropathic pain	11
The gut-brain axis and gut inflammation in Parkinson’s disease: stopping neurodegeneration at the toll gate	11
Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases	11
Deciphering Alzheimer’s disease: predicting new therapeutic strategies via improved understanding of biology and pathogenesis	11
Novel drug targets for treatment of cryptosporidiosis	11
Novel immune targets for the treatment of triple-negative breast cancer	11
Desmoplastic small round cell tumor (DSRCT): emerging therapeutic targets and future directions for potential therapies	10
Glutamatergic dysregulation in mood disorders: opportunities for the discovery of novel drug targets	10
Fatty acid synthase: a druggable driver of breast cancer brain metastasis	10
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)	10
Salivary gland cancer in the era of immunotherapy: can we exploit tumor microenvironment?	10
Transglutaminase 2 as a therapeutic target for neurological conditions	10
Targeting the tumor microenvironment in cholangiocarcinoma: implications for therapy	10
Therapeutic targets for enterovirus infections	10
Emerging therapeutic targets for nasopharyngeal carcinoma: opportunities and challenges	9
The CB2 cannabinoid receptor as a therapeutic target in the central nervous system	9
NTRK fusions in colorectal cancer: clinical meaning and future perspective	9
A vasculature-centric approach to developing novel treatment options for glioblastoma	9
Targeting the N332-supersite of the HIV-1 envelope for vaccine design	9
Prognostic relevance of programmed cell death protein 1/programmed death-ligand 1 pathway in thymic malignancies with combined immunohistochemical and biomolecular approach	9
Novel regulators of PrPC expression as potential therapeutic targets in prion diseases	9
Beyond type 2 cytokines in asthma - new insights from old clinical trials	9
The Nrf2 pathway in psychiatric disorders: pathophysiological role and potential targeting	9
Targeting SHP2 phosphatase in hematological malignancies	9
Emerging therapeutic targets for osteoarthritis	8
Cholangiocarcinoma: what are the most valuable therapeutic targets – cancer-associated fibroblasts, immune cells, or beyond T cells?	8
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models	8
Peripheral vascular disease: preclinical models and emerging therapeutic targeting of the vascular endothelial growth factor ligand-receptor system	8
Ephrin or not? Six tough questions on Eph targeting	8
Inflammasomes: a preclinical assessment of targeting in atherosclerosis	8
Preclinical insights into therapeutic targeting of KCC2 for disorders of neuronal hyperexcitability	8
Emerging role for the Serum Response Factor (SRF) as a potential therapeutic target in cancer	8
Uncovering key targets of success for immunotherapy in pancreatic cancer	8
Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging	8
Casein Kinase II exacerbates rheumatoid arthritis via promoting Th1 and Th17 cell inflammatory responses	8
New insights into targeting hepatic cystogenesis in autosomal dominant polycystic liver and kidney disease	8
Disease progression pathways of wet AMD: opportunities for new target discovery	8
The α9α10 nicotinic acetylcholine receptor: a compelling drug target for hearing loss?	8
Emerging therapeutic targets for cardiac arrhythmias: role of STAT3 in regulating cardiac fibroblast function	8
Glycans: potential therapeutic targets for cholangiocarcinoma and their therapeutic and diagnostic implications	7
Dapagliflozin mitigates ovalbumin-prompted airway inflammatory-oxidative successions and associated bronchospasm in a rat model of allergic asthma	7
Targeting the intrinsically disordered architectural High Mobility Group A (HMGA) oncoproteins in breast cancer: learning from the past to design future strategies	7
The role of immune response in the pathogenesis of idiopathic pulmonary fibrosis: far beyond the Th1/Th2 imbalance	7
Retinal vein occlusion: drug targets and therapeutic implications	7
Enteroviruses and coronaviruses: similarities and therapeutic targets	7
Potential of IDH mutations as immunotherapeutic targets in gliomas: a review and meta-analysis	7
Targeting fetal hemoglobin expression to treat β hemoglobinopathies	7
Apoptosis signal-regulating kinase 1 (ASK1) as a therapeutic target for neurological diseases	7
Hypoplastic left heart syndrome (HLHS): molecular pathogenesis and emerging drug targets for cardiac repair and regeneration	7
The role of the prolactin receptor pathway in the pathogenesis of glioblastoma: what do we know so far?	7
Polyglutamine spinocerebellar ataxias: emerging therapeutic targets	7
Tenosynovial giant cell tumors (TGCT): molecular biology, drug targets and non-surgical pharmacological approaches	7
Riboswitches as therapeutic targets: promise of a new era of antibiotics	7
Glycometabolic rearrangements–aerobic glycolysis in pancreatic ductal adenocarcinoma (PDAC): roles, regulatory networks, and therapeutic potential	7
Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential	7
A short report on NGM282/aldafermin for the treatment of nonalcoholic steatohepatitis (NASH)	6
The role of the sigma-1 receptor in neuroprotection: Comment on Nrf-2 as a therapeutic target in ischemic stroke	6
Acute myeloid leukemia: therapeutic targeting of stem cells	6
Defibrotide: potential for treating endothelial dysfunction related to viral and post-infectious syndromes	6
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment	6
Beyond basic research: the contribution of cathepsin B to cancer development, diagnosis and therapy	6
Modulations of ferroptosis in lung cancer therapy	6
Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications	6
Targeting calcium-mediated inter-organellar crosstalk in cardiac diseases	6
Taking the road less traveled – the therapeutic potential of CBP/β-catenin antagonists	6
BRCA mutations in pancreatic cancer and progress in their targeting	6
Targeting the EGFR signaling pathway in cancer therapy: What’s new in 2023?	6
Triple-negative breast cancer drug resistance, durable efficacy, and cure: how advanced biological insights and emerging drug modalities could transform progress	6

TROP2 (trophoblast cell-surface antigen 2): a drug target for breast cancer	6
Emerging roles of autophagy in the development and treatment of urothelial carcinoma of the bladder	6
The potential of Slit2 as a therapeutic target for central nervous system disorders	6
Airway smooth muscle in contractility and remodeling of asthma: potential drug target mechanisms	5
Parasite and host kinases as targets for antimalarials	5
Cortical projection neurons as a therapeutic target in multiple sclerosis	5
Targeting Aggressive Fibroblasts to Enhance the Treatment of Pancreatic Cancer	5
An update on novel pharmacological agents for primary sclerosing cholangitis	5
Novel therapeutic targets for diabetes-related wounds or ulcers: an update on preclinical and clinical research	5
Bromodomain-containing protein 4 (BRD4): a key player in inflammatory bowel disease and potential to inspire epigenetic therapeutics	5
Myelofibrosis: challenges for preclinical models and emerging therapeutic targets	5
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	5
Emerging therapeutic targets and preclinical models for severe asthma	5
Senescent cells: targeting and therapeutic potential of senolytics in age-related diseases with a particular focus on the heart	5
Emerging therapeutic targets for narcolepsy	5
An overview of novel antimicrobial carbonic anhydrase inhibitors	5
KRAS G12C inhibition and innate immune targeting	5
Clostridioides difficile: innovations in target discovery and potential for therapeutic success	5
Blockade of CD47 or SIRPα: a new cancer immunotherapy	5
Leucine-rich repeat kinase 2 (LRRK2): an update on the potential therapeutic target for Parkinson’s disease	5
Polycythemia vera: the current status of preclinical models and therapeutic targets	5
Dyskinesia and Parkinson’s disease: animal model, drug targets, and agents in preclinical testing	5
Genome-wide CRISPR screens for the identification of therapeutic targets for cancer treatment	4
Early clinical and pre-clinical therapy development in Nemaline myopathy	4
Hepatitis B virus: promising drug targets and therapeutic implications	4
Targeting the CTLA-4/B7 axes in glioblastoma: preclinical evidence and clinical interventions	4
Myocarditis: causes, mechanisms, and evolving therapies	4
LSD1: a viable therapeutic target in cutaneous squamous cell carcinoma?	4
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath	4
Emerging therapeutic targets for epilepsy: preclinical insights	4
Spotlight on liver macrophages for halting injury and progression in nonalcoholic fatty liver disease	4
NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): seven years between lights and shadows	4
Atypical teratoid rhabdoid tumor (ATRT): disease mechanisms and potential drug targets	4
Tryptophan 2,3-dioxygenase, a novel therapeutic target for Parkinson’s disease	4
Epigenetics in atherosclerosis: key features and therapeutic implications	4
Refining targeted therapeutic approaches in pancreatic cancer: from histology and molecular pathology to the clinic	4
Novel and emerging targets for cholangiocarcinoma progression: therapeutic implications	4
Toxoplasma gondii infection: novel emerging therapeutic targets	4
Expression of a short antibody heavy chain peptide effectively antagonizes adenosine 2A receptor in vitro and in vivo	4
Targeting neuroprotective functions of astrocytes in neuroimmune diseases	4
Hepatocellular carcinoma (HCC): the most promising therapeutic targets in the preclinical arena based on tumor biology characteristics	4
Mantle cell lymphoma: insights into therapeutic targets at the preclinical level	4