Expert Opinion on Therapeutic Targets

Article	Citations
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines	102
lncRNAs: potential therapeutic targets and biomarkers for pancreatic cancer?	56
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy	52
Mitochondrial permeability transition pore: a snapshot of a therapeutic target	45
IL-36: a therapeutic target for ulcerative colitis?	37
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects	36
Interleukin-18 in cancer immunology and immunotherapy	35
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA	35
NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): seven years between lights and shadows	33
Axial spondyloarthritis: emerging drug targets	33
Aberrations of DNA repair pathways in prostate cancer: a cornerstone of precision oncology	30
Glycoproteins and longevity: an interview with Professor Gordan Lauc	30
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement	30
Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications	29
Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing	28
The sigma-1 receptor: a mechanistically-informed therapeutic target for antidepressants	26
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets	25
MDA-9/Syntenin as a therapeutic cancer metastasis target: current molecular and preclinical understanding	25
Current challenges in the discovery of treatments against Mayaro fever	25
A short report on NGM282/aldafermin for the treatment of nonalcoholic steatohepatitis (NASH)	24
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer	24
Clostridioides difficile: innovations in target discovery and potential for therapeutic success	23
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study	23
The potential of multimolecular G-quadruplex structures for targeted treatment of Amyotrophic Lateral Sclerosis	23
Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy	23

Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age	22
Novel signatures of prostate cancer progression and therapeutic resistance	22
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath	22
The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?	22
The challenges and potential of microRNA-based therapy for patients with liver failure syndromes and hepatocellular carcinoma	21
Antibacterial carbonic anhydrase inhibitors targeting Vibrio cholerae enzymes	21
Esophageal cancer: emerging therapeutics	20
Uncovering key targets of success for immunotherapy in pancreatic cancer	20
Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis	20
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling	19
The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin	19
What do we know about the renin angiotensin system and inflammatory bowel disease?	19
Progeria: a perspective on potential drug targets and treatment strategies	18
Molecular pharmacology of multitarget cyclin-dependent kinase inhibitors in human colorectal carcinoma cells	18
Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABAB R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model	17
Tenosynovial giant cell tumors (TGCT): molecular biology, drug targets and non-surgical pharmacological approaches	16
Targeting PRL phosphatases in hematological malignancies	16
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)	15
Promising therapeutic targets for the treatment of urine storage dysfunction: what’s the status?	15
Hepatocellular carcinoma (HCC): the most promising therapeutic targets in the preclinical arena based on tumor biology characteristics	15
Targeting acid-sensing ion channels in glioblastoma: is there any therapeutic potential?	15
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update	14
Granzyme B as a therapeutic target: an update in 2022	14
Emerging therapeutic targets for anorexia nervosa	14
Myocarditis: causes, mechanisms, and evolving therapies	14
Sjögren’s syndrome: shedding light on emerging and key drug targets	14
Atypical teratoid rhabdoid tumor (ATRT): disease mechanisms and potential drug targets	14
ULK1 as a therapeutic target in kidney diseases: Current perspective	14
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications	13
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?	13
GDF15: a potential therapeutic target for type 1 diabetes	13
Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy	13
Mitochondria makeover: unlocking the path to healthy longevity	12
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer	12
Hypoplastic left heart syndrome (HLHS): molecular pathogenesis and emerging drug targets for cardiac repair and regeneration	12
Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential	12
Retinal vein occlusion: drug targets and therapeutic implications	12
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets	12
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?	12
The mechanisms and therapeutic targets of ferroptosis in cancer	11
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?	11
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression	11
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies	11
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers	11
NTRK fusions in colorectal cancer: clinical meaning and future perspective	11
Epigenetic regulatory mechanisms of histone acetylation in the treatment of cutaneous squamous cell carcinoma	10
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential	10
Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness	10
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	10
Tackling retinal ganglion cell apoptosis in glaucoma: role of adenosine receptors	10

Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations	10
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders	10
Leveraging AI to identify dual-purpose aging and disease targets	10
Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level	10
Neuromodulatory effects of SARS-CoV2 infection: Possible therapeutic targets	10
Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies	10
The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies	9
Influence of the inflammasome complex on psychiatric disorders: clinical and preclinical studies	9
An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models	9
Current strategies for targeting HPK1 in cancer and the barriers to preclinical progress	9
Cellular role of CD93 and its potential as a future therapeutic target	9
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2	9
Shedding light on emerging therapeutic targets for chordoma	9
Emerging therapeutic targets for epilepsy: preclinical insights	9
ORF6, a repressor of the MHC class I pathway: new molecular target for SARS-CoV-2 drug discovery?	9
The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state	9
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment	9
TAR DNA-binding protein of 43 kDa (TDP-43) and amyotrophic lateral sclerosis (ALS): a promising therapeutic target	9
Tumor-associated neutrophils: orchestrating cancer pathobiology and therapeutic resistance	9
Ways of modulating GABA transporters to treat neurological disease	9
Cardiac conduction diseases: understanding the molecular mechanisms to uncover targets for future treatments	8
New therapeutic targets for endometrial cancer: a glimpse into the preclinical sphere	8
Medulloblastoma: novel insights into emerging therapeutic targets	8
Restoring FXR expression as a novel treatment strategy in liver cancer and other liver disorders	8
The potential for OGG1 inhibition to be a therapeutic strategy for pulmonary diseases	8
Role of the P2Y12 receptor on thrombus formation and evolution in therapeutic strategies	8
Targeting the Tumor-Tumor Microenvironment Crosstalk	8
An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection	8
Targeting the TRPV1 pain pathway in osteoarthritis of the knee	8
Potential therapeutic targets to prevent organ damage in chronic pulmonary sarcoidosis	8
The emerging role of TIM-3 in colorectal cancer: a promising target for immunotherapy	8
Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles	8
Considerations on the implementation of MAP4K4 inhibitors as cancer treatment	8
The emerging role of Tetraspanin 32 in autoimmune diseases: from discovery to relevant theranostics?	8
Enteroviruses and coronaviruses: similarities and therapeutic targets	8
TROP2 (trophoblast cell-surface antigen 2): a drug target for breast cancer	7
Emerging drug targets for triple-negative breast cancer: a guided tour of the preclinical landscape	7
Renal fibrosis as a hallmark of diabetic kidney disease: potential role of targeting transforming growth factor-beta (TGF-β) and related molecules	7
Emerging role for the Serum Response Factor (SRF) as a potential therapeutic target in cancer	7
A two-decade journey in identifying high mobility group box 1 (HMGB1) and procathepsin L (pCTS-L) as potential therapeutic targets for sepsis	7
Gateway reflexes are neural circuits that establish the gateway of immune cells to regulate tissue specific inflammation	7
aMMP-8 point-of-care - diagnostic methods and treatment modalities in periodontitis and peri-implantitis	7
Pharmacological targeting of ECM homeostasis, fibroblast activation and invasion for the treatment of pulmonary fibrosis	7
Acute myeloid leukemia: therapeutic targeting of stem cells	7
Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors?	6
Tumor cells-derived extracellular vesicles carry circ_0064516 competitively inhibit microRNA-6805-3p and promote cervical cancer angiogenesis and tumor growth	6
Repurposing fluoxetine to treat lymphocytic leukemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction	6
Renal ciliopathies: promising drug targets and prospects for clinical trials	6
Can targeting the FGF23-αKlotho signaling system delay phosphate-driven organ damage?	6
Fatty liver disease: time to target CCR5?	6
Targeting mucosal healing in Crohn’s disease: efficacy of novel pathways and therapeutic targets	6
Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets	6
Targeting SHP2 phosphatase in hematological malignancies	6
The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review	6
Fatty acid-mediated signaling as a target for developing type 1 diabetes therapies	6
Modulating multidrug resistance to drug-based antitumor therapies through NF-κB signaling pathway: mechanisms and perspectives	6
Toxoplasma gondii infection: novel emerging therapeutic targets	6
Cholangiocarcinoma: what are the most valuable therapeutic targets – cancer-associated fibroblasts, immune cells, or beyond T cells?	6
Arenobufagin induces cell apoptosis by modulating the cell cycle regulator claspin and the JNK pathway in nasopharyngeal carcinoma cells	6
Endothelial dysfunction: a therapeutic target in bacterial sepsis?	6
Kv1.3 in the spotlight for treating immune diseases	5
Novel and emerging targets for cholangiocarcinoma progression: therapeutic implications	5
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases	5
Focusing on oligomeric tau as a therapeutic target in Alzheimer’s disease and other tauopathies	5
Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy	5
Refining targeted therapeutic approaches in pancreatic cancer: from histology and molecular pathology to the clinic	5
Novel chromobox 2 inhibitory peptide decreases tumor progression	5
Enhancer of zeste homolog 2 (EZH2) in endocrine tumors: current knowledge and future directions	5
MT1-MMP – A potential drug target for the management of the obesity	5
Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging	5
Exploring PKG signaling as a therapeutic avenue for pressure overload, ischemia, and HFpEF	5
Unlocking the potential of melanotransferrin (CD228): implications for targeted drug development and novel therapeutic avenues	5
Targeting GABA receptors with chalcone derivative compounds, what is the evidence?	5
High levels of HDAC expression correlate with microglial aging	5
Sirtuins as therapeutic targets in diabetes	5
Therapeutic application of GLP-1 and GIP receptor agonists in Parkinson’s disease	5
Epigenetic regulation of immune cells in systemic lupus erythematosus: insight from chromatin accessibility	5
XBP1 as a novel molecular target to attenuate drug resistance in hepatocellular carcinoma	5
Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?	5
TGF-β as a therapeutic target in the infarcted and failing heart: cellular mechanisms, challenges, and opportunities	5

Glycometabolic rearrangements–aerobic glycolysis in pancreatic ductal adenocarcinoma (PDAC): roles, regulatory networks, and therapeutic potential	5
Feasibility and considerations of epsin2 as a candidate target for multiple system atrophy treatment	5
miR-181a : regulatory roles, cancer-associated signaling pathway disruptions, and therapeutic potential	5
Cytokines of the interleukin-6 family as emerging targets in inflammatory bowel disease	5
Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy	4
Type 1 diabetes: key drug targets and how they could influence future therapeutics	4
CDK6: an attractive therapeutic target for T-ALL/LBL	4
The role of ubiquitination in microbial infection induced endothelial dysfunction: potential therapeutic targets for sepsis	4
Glucocorticoid receptors participate in epilepsy in FCDII patients and MP model rats: A potential therapeutic target for epilepsy in patients with focal cortical dysplasia II (FCDII)	4
Candidate molecular targets uncovered in mouse lifespan extension studies	4
Potential molecular targets for the pharmacologic management of non-traumatic osteonecrosis	4
HIV Pol: does it offer therapeutic targets for HIV?	4
The molecular mechanisms and targeting strategies of transcription factors in cholangiocarcinoma	4
Therapeutic perspectives on PDE4B inhibition in adipose tissue dysfunction and chronic liver injury	4
Epigenetic determinants in soft tissue sarcomas: molecular mechanisms and therapeutic targets	4
Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) – the involvement of mitochondrial quality control, autophagy, and antioxidant response	4
Lipocalin-2 as a therapeutic target for diabetes neurological complications	4
Targeting endoplasmic reticulum stress—the responder to lipotoxicity and modulator of non-alcoholic fatty liver diseases	4
Peripheral vascular disease: preclinical models and emerging therapeutic targeting of the vascular endothelial growth factor ligand-receptor system	4
SCN1A as a therapeutic target for Dravet syndrome	4
Potential of IDH mutations as immunotherapeutic targets in gliomas: a review and meta-analysis	4
Airway smooth muscle in contractility and remodeling of asthma: potential drug target mechanisms	4
The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer’s	4
The participation of non-canonical autophagic proteins in the autophagy process and their potential as therapeutic targets	4