Expert Opinion on Therapeutic Targets

Article	Citations
Esophageal cancer: emerging therapeutics	77
Aberrations of DNA repair pathways in prostate cancer: a cornerstone of precision oncology	47
Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease	41
Omentin-1: a newly discovered warrior against metabolic related diseases	39
TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2	37
HSP47: a potential target for fibrotic diseases and implications for therapy	35
CCR5 is a potential therapeutic target for cancer	35
PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date	33
Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations	28
Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy	27
Microglia as therapeutic targets after neurological injury: strategy for cell therapy	26
The mechanisms and therapeutic targets of ferroptosis in cancer	26
Is neurotrophin-3 (NT-3): a potential therapeutic target for depression and anxiety?	25
The gut microbiome as a target for adjuvant therapy in obstructive sleep apnea	25
Calpain as a therapeutic target in cancer	25
Systemic lupus erythematosus (SLE): emerging therapeutic targets	25
The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer’s	24
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases	24
MET alterations and their impact on the future of non-small cell lung cancer (NSCLC) targeted therapies	24
Liver X receptor: a potential target in the treatment of atherosclerosis	23
Tumor-associated neutrophils: orchestrating cancer pathobiology and therapeutic resistance	23
An overview of novel antimicrobial carbonic anhydrase inhibitors	23
Redox-sensitive TRP channels: a promising pharmacological target in chemotherapy-induced peripheral neuropathy	21
Therapeutic application of GLP-1 and GIP receptor agonists in Parkinson’s disease	21
Emerging therapeutic targets for cerebral edema	20

Targeting Fc effector function in vaccine design	20
Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability	19
CD36 as a target for metabolic modulation therapy in cardiac disease	19
Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases	18
Targeting RUNX1 in acute myeloid leukemia: preclinical innovations and therapeutic implications	18
TAM kinase inhibition and immune checkpoint blockade– a winning combination in cancer treatment?	18
Autoimmune encephalitis: novel therapeutic targets at the preclinical level	18
Endothelial dysfunction: a therapeutic target in bacterial sepsis?	18
Non-histone substrates of histone deacetylases as potential therapeutic targets in epilepsy	18
Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity	18
Potassium channels as prominent targets and tools for the treatment of epilepsy	17
Targeting TIM-3 in solid tumors: innovations in the preclinical and translational realm and therapeutic potential	17
Epigenetic regulation in Alzheimer’s disease: is it a potential therapeutic target?	17
Disease progression pathways of wet AMD: opportunities for new target discovery	17
Nrf2 as a therapeutic target in ischemic stroke	17
Emerging therapeutic targets for schizophrenia: a framework for novel treatment strategies for psychosis	16
Novel immune targets for the treatment of triple-negative breast cancer	16
Targeting the EGFR signaling pathway in cancer therapy: What’s new in 2023?	16
Emerging therapeutic targets for cardiac hypertrophy	16
GDF15: a potential therapeutic target for type 1 diabetes	15
The potential for immune checkpoint modulators in cerebrovascular injury and inflammation	15
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)	15
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study	15
Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles	14
The role of immune response in the pathogenesis of idiopathic pulmonary fibrosis: far beyond the Th1/Th2 imbalance	14
Renal fibrosis as a hallmark of diabetic kidney disease: potential role of targeting transforming growth factor-beta (TGF-β) and related molecules	14
The CB2 cannabinoid receptor as a therapeutic target in the central nervous system	14
Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway	14
Transglutaminase 2 as a therapeutic target for neurological conditions	14
Emerging therapeutic targets for sepsis	14
A vasculature-centric approach to developing novel treatment options for glioblastoma	14
OXPHOS-targeting drugs in oncology: new perspectives	13
Emerging therapeutic targets for gastric cancer from a host-Helicobacter pylori interaction perspective	13
The Nrf2 pathway in psychiatric disorders: pathophysiological role and potential targeting	13
Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) – the involvement of mitochondrial quality control, autophagy, and antioxidant response	13
Targeting SHP2 phosphatase in hematological malignancies	12
Fatty acid synthase: a druggable driver of breast cancer brain metastasis	12
Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging	12
Targeting the tumor microenvironment in cholangiocarcinoma: implications for therapy	12
TROP2 (trophoblast cell-surface antigen 2): a drug target for breast cancer	11
Peripheral vascular disease: preclinical models and emerging therapeutic targeting of the vascular endothelial growth factor ligand-receptor system	11
Emerging therapeutic targets for osteoarthritis	11
The α9α10 nicotinic acetylcholine receptor: a compelling drug target for hearing loss?	11
Glutamatergic dysregulation in mood disorders: opportunities for the discovery of novel drug targets	11
Riboswitches as therapeutic targets: promise of a new era of antibiotics	11
NTRK fusions in colorectal cancer: clinical meaning and future perspective	11
Tenosynovial giant cell tumors (TGCT): molecular biology, drug targets and non-surgical pharmacological approaches	10
Beyond basic research: the contribution of cathepsin B to cancer development, diagnosis and therapy	10
Bromodomain-containing protein 4 (BRD4): a key player in inflammatory bowel disease and potential to inspire epigenetic therapeutics	10
Targeting citrullination in autoimmunity: insights learned from preclinical mouse models	9

Emerging therapeutic targets for cardiac arrhythmias: role of STAT3 in regulating cardiac fibroblast function	9
Cholangiocarcinoma: what are the most valuable therapeutic targets – cancer-associated fibroblasts, immune cells, or beyond T cells?	9
Emerging role for the Serum Response Factor (SRF) as a potential therapeutic target in cancer	9
Targeting the Tumor-Tumor Microenvironment Crosstalk	9
Taking the road less traveled – the therapeutic potential of CBP/β-catenin antagonists	9
Leucine-rich repeat kinase 2 (LRRK2): an update on the potential therapeutic target for Parkinson’s disease	9
Enteroviruses and coronaviruses: similarities and therapeutic targets	9
Dapagliflozin mitigates ovalbumin-prompted airway inflammatory-oxidative successions and associated bronchospasm in a rat model of allergic asthma	9
Glycometabolic rearrangements–aerobic glycolysis in pancreatic ductal adenocarcinoma (PDAC): roles, regulatory networks, and therapeutic potential	9
Retinal vein occlusion: drug targets and therapeutic implications	9
Human prion disease: molecular pathogenesis, and possible therapeutic targets and strategies	8
Targeting neuroprotective functions of astrocytes in neuroimmune diseases	8
Glycans: potential therapeutic targets for cholangiocarcinoma and their therapeutic and diagnostic implications	8
Parasite and host kinases as targets for antimalarials	8
Early clinical and pre-clinical therapy development in Nemaline myopathy	8
Hypoplastic left heart syndrome (HLHS): molecular pathogenesis and emerging drug targets for cardiac repair and regeneration	8
NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): seven years between lights and shadows	8
Airway smooth muscle in contractility and remodeling of asthma: potential drug target mechanisms	8
Targeting calcium-mediated inter-organellar crosstalk in cardiac diseases	8
Targeting fetal hemoglobin expression to treat β hemoglobinopathies	8
Modulations of ferroptosis in lung cancer therapy	8
Casein Kinase II exacerbates rheumatoid arthritis via promoting Th1 and Th17 cell inflammatory responses	8
Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential	8
Veliparib (ABT-888), a PARP inhibitor potentiates the cytotoxic activity of 5-fluorouracil by inhibiting MMR pathway through deregulation of MSH6 in colorectal cancer stem cells	8
Defibrotide: potential for treating endothelial dysfunction related to viral and post-infectious syndromes	8
Uncovering key targets of success for immunotherapy in pancreatic cancer	8
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	8
Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets	8
Atypical teratoid rhabdoid tumor (ATRT): disease mechanisms and potential drug targets	7
The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state	7
Advances in molecular therapies for targeting pathophysiology in spinal cord injury	7
Triple-negative breast cancer drug resistance, durable efficacy, and cure: how advanced biological insights and emerging drug modalities could transform progress	7
Ubiquitin-specific protease 7 (USP7): an emerging drug target for cancer treatment	7
Granzyme B as a therapeutic target: an update in 2022	7
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment	7
A short report on NGM282/aldafermin for the treatment of nonalcoholic steatohepatitis (NASH)	7
Dyskinesia and Parkinson’s disease: animal model, drug targets, and agents in preclinical testing	7
Galectin-3: therapeutic targeting in liver disease	7
Potential of IDH mutations as immunotherapeutic targets in gliomas: a review and meta-analysis	7
Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis	7
The role of the sigma-1 receptor in neuroprotection: Comment on Nrf-2 as a therapeutic target in ischemic stroke	7
Acute myeloid leukemia: therapeutic targeting of stem cells	7
Efflux systems as a target for anti-biofilm nanoparticles: perspectives on emerging applications	6
Emerging roles of autophagy in the development and treatment of urothelial carcinoma of the bladder	6
BRCA mutations in pancreatic cancer and progress in their targeting	6
Toxoplasma gondii infection: novel emerging therapeutic targets	6
Targeting the CTLA-4/B7 axes in glioblastoma: preclinical evidence and clinical interventions	6
Treatment update for vitiligo based on autoimmune inhibition and melanocyte protection	6
Sjögren’s syndrome: shedding light on emerging and key drug targets	6
Hepatocellular carcinoma (HCC): the most promising therapeutic targets in the preclinical arena based on tumor biology characteristics	6
Spotlight on liver macrophages for halting injury and progression in nonalcoholic fatty liver disease	6
Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?	6
Novel therapeutic targets for diabetes-related wounds or ulcers: an update on preclinical and clinical research	6
KRAS G12C inhibition and innate immune targeting	6
Tryptophan 2,3-dioxygenase, a novel therapeutic target for Parkinson’s disease	6
Neuropathic ocular surface pain: Emerging drug targets and therapeutic implications	6
Hepatitis B virus: promising drug targets and therapeutic implications	6
Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications	6
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling	5
Clostridioides difficile: innovations in target discovery and potential for therapeutic success	5
Cortical projection neurons as a therapeutic target in multiple sclerosis	5
Novel and emerging targets for cholangiocarcinoma progression: therapeutic implications	5
An update on novel pharmacological agents for primary sclerosing cholangitis	5
Emerging therapeutic targets for narcolepsy	5
Myocarditis: causes, mechanisms, and evolving therapies	5
Vitamin D/vitamin D receptor pathway in non-alcoholic fatty liver disease	5
Inhibition of MK2 kinase as a potential therapeutic target to control neuroinflammation in Alzheimer’s disease	5
The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies	5
Refining targeted therapeutic approaches in pancreatic cancer: from histology and molecular pathology to the clinic	5
Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy	5
The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting	5
lncRNAs: potential therapeutic targets and biomarkers for pancreatic cancer?	5
A two-decade journey in identifying high mobility group box 1 (HMGB1) and procathepsin L (pCTS-L) as potential therapeutic targets for sepsis	5
Targets for obstructive sleep apnea pharmacotherapy: principles, approaches, and emerging strategies	5
Targeting endoplasmic reticulum stress—the responder to lipotoxicity and modulator of non-alcoholic fatty liver diseases	5
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath	5
Emerging therapeutic targets for epilepsy: preclinical insights	5
The brain heme oxygenase/biliverdin reductase system as a target in drug research and development	5
Targeting Aggressive Fibroblasts to Enhance the Treatment of Pancreatic Cancer	5
The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review	5

aMMP-8 point-of-care - diagnostic methods and treatment modalities in periodontitis and peri-implantitis	5
Myelofibrosis: challenges for preclinical models and emerging therapeutic targets	5
Emerging pharmacologic interventions for pre-eclampsia treatment	4
Neuropathogenesis of HIV and emerging therapeutic targets	4
Focusing on oligomeric tau as a therapeutic target in Alzheimer’s disease and other tauopathies	4
Lipid metabolism in malignant tumor brain metastasis: reprogramming and therapeutic potential	4
What do we know about the renin angiotensin system and inflammatory bowel disease?	4
Potential therapeutic targets for Mpox: the evidence to date	4
Tackling retinal ganglion cell apoptosis in glaucoma: role of adenosine receptors	4
Modulating multidrug resistance to drug-based antitumor therapies through NF-κB signaling pathway: mechanisms and perspectives	4
The mineralocorticoid receptor signal could be a new molecular target for the treatment of diabetic retinal complication	4
Novel signatures of prostate cancer progression and therapeutic resistance	4
Emerging drug targets for colon cancer: A preclinical assessment	4
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders	4
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets	4
Glucocorticoid receptors participate in epilepsy in FCDII patients and MP model rats: A potential therapeutic target for epilepsy in patients with focal cortical dysplasia II (FCDII)	4
Tuft cells: an emerging therapeutic target for pancreatitis and pancreatic cancer?	3
Interleukin-18 in cancer immunology and immunotherapy	3
Emerging therapeutic targets for retinoblastoma	3
Emerging drug targets for triple-negative breast cancer: a guided tour of the preclinical landscape	3
Medulloblastoma: novel insights into emerging therapeutic targets	3
Novel chromobox 2 inhibitory peptide decreases tumor progression	3
The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?	3
A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function	3
Axial spondyloarthritis: emerging drug targets	3
Identifying molecular mechanisms of acute to chronic pain transition and potential drug targets	3
New therapeutic targets for endometrial cancer: a glimpse into the preclinical sphere	3
Progeria: a perspective on potential drug targets and treatment strategies	3
Influence of the inflammasome complex on psychiatric disorders: clinical and preclinical studies	3
H3K27-altered diffuse midline glioma: a paradigm shifting opportunity in direct delivery of targeted therapeutics	3
Fatty acid-mediated signaling as a target for developing type 1 diabetes therapies	3
Powering down the mitochondrial LonP1 protease: a novel strategy for anticancer therapeutics	3
Emerging therapeutic targets for anorexia nervosa	3
The genetic background of Parkinson’s disease and novel therapeutic targets	3
New drug targets for the treatment of gout arthritis: what’s new?	3
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age	3
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets	3