Expert Opinion on Therapeutic Targets

Article	Citations
Assessing platelet-derived extracellular vesicles for potential as therapeutic targets in cardiovascular diseases	77
A vasculature-centric approach to developing novel treatment options for glioblastoma	47
Gateway reflexes are neural circuits that establish the gateway of immune cells to regulate tissue specific inflammation	45
lncRNAs: potential therapeutic targets and biomarkers for pancreatic cancer?	39
Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy	38
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?	35
Targeting ALK receptors in non-small cell lung cancer: what is the road ahead?	33
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer	30
Mitochondrial permeability transition pore: a snapshot of a therapeutic target	29
Powering down the mitochondrial LonP1 protease: a novel strategy for anticancer therapeutics	28
Tolperisone induces UPR-mediated tumor inhibition and synergizes with proteasome inhibitor and immunotherapy by targeting LSD1	27
Mitochondria makeover: unlocking the path to healthy longevity	26
HIV Pol: does it offer therapeutic targets for HIV?	26
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy	24
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications	24
Fatty liver disease: time to target CCR5?	24
Acute myeloid leukemia: therapeutic targeting of stem cells	24
Novel therapeutic targets for diabetes-related wounds or ulcers: an update on preclinical and clinical research	23
Targeting VCAM-1: a therapeutic opportunity for vascular damage	23
Emerging therapeutic targets for narcolepsy	23
Dyskinesia and Parkinson’s disease: animal model, drug targets, and agents in preclinical testing	21
IL-36: a therapeutic target for ulcerative colitis?	21
Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential	20
Glucose-6-phosphate dehydrogenase: a therapeutic target for ovarian cancer	20
Glucocorticoid receptors participate in epilepsy in FCDII patients and MP model rats: A potential therapeutic target for epilepsy in patients with focal cortical dysplasia II (FCDII)	19

Human prion disease: molecular pathogenesis, and possible therapeutic targets and strategies	18
The ATP-sensitive potassium channel: a therapeutic target for neurodegeneration?	18
The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review	18
MET alterations and their impact on the future of non-small cell lung cancer (NSCLC) targeted therapies	18
An update on novel pharmacological agents for primary sclerosing cholangitis	18
Advances in cerebellar disorders: pre-clinical models, therapeutic targets, and challenges	17
Progress and challenges in glypican-3 targeting for hepatocellular carcinoma therapy	17
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA	17
Ubiquitin-specific protease 7 (USP7): an emerging drug target for cancer treatment	16
Understanding the role of galectins toward influenza A virus infection	16
Interleukin-18 in cancer immunology and immunotherapy	16
Druggable genes for therapeutic targeting in PTH signaling for osteoporosis	15
Retinal vein occlusion: drug targets and therapeutic implications	15
An overview of novel antimicrobial carbonic anhydrase inhibitors	15
Endothelial dysfunction: a therapeutic target in bacterial sepsis?	15
Targeting the CTLA-4/B7 axes in glioblastoma: preclinical evidence and clinical interventions	14
Targeted therapeutic strategies for the kidney	14
OXPHOS-targeting drugs in oncology: new perspectives	14
Galectin-3: therapeutic targeting in liver disease	14
TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2	14
Correction	14
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines	14
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?	14
Arenobufagin induces cell apoptosis by modulating the cell cycle regulator claspin and the JNK pathway in nasopharyngeal carcinoma cells	14
Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors?	13
Glycoproteins and longevity: an interview with Professor Gordan Lauc	13
VPS35 or retromer as a potential target for neurodegenerative disorders: barriers to progress	13
Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder	12
Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing	12
Can we suppress chronic systemic inflammation and postpone age-related diseases by targeting the IgG glycome?	12
Navigating the landscape of psoriasis therapy: novel targeted pathways and emerging trends	11
miR-26a-5p restoration via EZH2 silencing blocks the IL-6/STAT3 axis to repress the growth of prostate cancer	11
PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date	11
Cholangiocarcinoma: what are the most valuable therapeutic targets – cancer-associated fibroblasts, immune cells, or beyond T cells?	11
Unraveling therapeutic targets in acute myeloid leukemia through multiplexed genome editing CRISPR screening	11
Guillain–Barré syndrome: immunopathogenesis and therapeutic targets	10
TGF-β as a therapeutic target in the infarcted and failing heart: cellular mechanisms, challenges, and opportunities	10
Tumor cells-derived extracellular vesicles carry circ_0064516 competitively inhibit microRNA-6805-3p and promote cervical cancer angiogenesis and tumor growth	10
Fatty acid-mediated signaling as a target for developing type 1 diabetes therapies	9
The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting	9
Renal ciliopathies: promising drug targets and prospects for clinical trials	9
Hypoplastic left heart syndrome (HLHS): molecular pathogenesis and emerging drug targets for cardiac repair and regeneration	9
Combining rejuvenation interventions in rodents: a milestone in biomedical gerontology whose time has come	9
NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): seven years between lights and shadows	9
Chemokine signaling in tumors: potential role of CXC chemokines and their receptors as glioblastoma therapeutic targets	9
Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway	9
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression	9
Targeting mucosal healing in Crohn’s disease: efficacy of novel pathways and therapeutic targets	9
The mineralocorticoid receptor signal could be a new molecular target for the treatment of diabetic retinal complication	8
Axial spondyloarthritis: emerging drug targets	8

Casein Kinase II exacerbates rheumatoid arthritis via promoting Th1 and Th17 cell inflammatory responses	8
The role of the sigma-1 receptor in neuroprotection: Comment on Nrf-2 as a therapeutic target in ischemic stroke	8
Emerging therapeutic targets for osteoarthritis	8
Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging	8
Hepatitis B virus: promising drug targets and therapeutic implications	8
Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications	8
Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?	8
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases	8
Toxoplasma gondii infection: novel emerging therapeutic targets	8
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets	8
Repurposing fluoxetine to treat lymphocytic leukemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction	8
Targeting SHP2 phosphatase in hematological malignancies	8
Leucine-rich repeat kinase 2 (LRRK2): an update on the potential therapeutic target for Parkinson’s disease	8
TRPC3: how current mechanistic understanding provides a basis for therapeutic targeting	8
Microglia as therapeutic targets after neurological injury: strategy for cell therapy	8
The role of immune response in the pathogenesis of idiopathic pulmonary fibrosis: far beyond the Th1/Th2 imbalance	8
Triple-negative breast cancer drug resistance, durable efficacy, and cure: how advanced biological insights and emerging drug modalities could transform progress	7
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement	7
Major depressive disorder (mdd): emerging immune targets at preclinical level	7
Targeting the EGFR signaling pathway in cancer therapy: What’s new in 2023?	7
Spotlight on liver macrophages for halting injury and progression in nonalcoholic fatty liver disease	7
Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets	7
Lipid metabolism in malignant tumor brain metastasis: reprogramming and therapeutic potential	7
Modulating multidrug resistance to drug-based antitumor therapies through NF-κB signaling pathway: mechanisms and perspectives	7
Targeting inflammasome complexes as a novel therapeutic strategy for mood disorders	7
Aberrations of DNA repair pathways in prostate cancer: a cornerstone of precision oncology	7
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers	7
The mechanisms and therapeutic targets of ferroptosis in cancer	7
Preclinical target validation for non-addictive therapeutics development for pain	7
Epigenetic regulatory mechanisms of histone acetylation in the treatment of cutaneous squamous cell carcinoma	7
MT1-MMP – A potential drug target for the management of the obesity	6
Therapeutic potential of RUNX1 and RUNX2 in bone metastasis of breast cancer	6
Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level	6
Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy	6
Innovations in treating acute graft-versus-host disease: a review of preclinical targets and strategies	6
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?	6
Duchenne cardiomyopathy: targeting ROS and NOX4 as a promising therapeutic strategy	6
Early clinical and pre-clinical therapy development in Nemaline myopathy	6
The endocannabinoid system as a therapeutic target in neuropathic pain: a review	6
Modulations of ferroptosis in lung cancer therapy	6
Tackling retinal ganglion cell apoptosis in glaucoma: role of adenosine receptors	6
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study	6
Novel therapeutic perspectives for crescentic glomerulonephritis through targeting parietal epithelial cell activation and proliferation	6
Signal peptide peptidase: a potential therapeutic target for parasitic and viral infections	6
Can we target insulin signalling for cognition therapeutics?	6
The role of Nrf2 in immune cells and inflammatory autoimmune diseases: a comprehensive review	5
A short report on NGM282/aldafermin for the treatment of nonalcoholic steatohepatitis (NASH)	5
PI3K and tankyrase inhibitors as therapeutic targets in colorectal cancer	5
XBP1 as a novel molecular target to attenuate drug resistance in hepatocellular carcinoma	5
An update on the development on tubulin inhibitors for the treatment of solid tumors	5
How will the identification and therapeutic intervention of genetic targets in oncology evolve for future therapy?	5
Focusing on oligomeric tau as a therapeutic target in Alzheimer’s disease and other tauopathies	5
Targeting RUNX1 in acute myeloid leukemia: preclinical innovations and therapeutic implications	5
Advances in molecular therapies for targeting pathophysiology in spinal cord injury	5
Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity	5
NTRK fusions in colorectal cancer: clinical meaning and future perspective	5
Leveraging AI to identify dual-purpose aging and disease targets	5
Epigenetic regulation of immune cells in systemic lupus erythematosus: insight from chromatin accessibility	5
Potential of αvβ6 and αvβ1 integrin inhibition for treatment of idiopathic pulmonary fibrosis	5
Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness	5
Glycometabolic rearrangements–aerobic glycolysis in pancreatic ductal adenocarcinoma (PDAC): roles, regulatory networks, and therapeutic potential	5
Targeting HIF-1 for prostate cancer: a synthesis of preclinical evidence	5
Novel and emerging targets for cholangiocarcinoma progression: therapeutic implications	5
Cytokines of the interleukin-6 family as emerging targets in inflammatory bowel disease	5
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	5
Current challenges in the discovery of treatments against Mayaro fever	5
The brain heme oxygenase/biliverdin reductase system as a target in drug research and development	5
Therapeutic application of GLP-1 and GIP receptor agonists in Parkinson’s disease	5
A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function	4
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential	4
Exploring PKG signaling as a therapeutic avenue for pressure overload, ischemia, and HFpEF	4
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders	4
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2	4
Targeting cyclin-dependent kinases in rheumatoid arthritis and psoriasis – a review of current evidence	4
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer	4
Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations	4
Unlocking the potential of melanotransferrin (CD228): implications for targeted drug development and novel therapeutic avenues	4
CD36 as a target for metabolic modulation therapy in cardiac disease	4
Kv1.3 in the spotlight for treating immune diseases	4
Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies	4

Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets	4
Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases	4
Therapeutic approaches targeting oncogenic proteins in myeloid leukemia: challenges and perspectives	4
The molecular mechanisms and targeting strategies of transcription factors in cholangiocarcinoma	3
Targeting fetal hemoglobin expression to treat β hemoglobinopathies	3
Clostridioides difficile: innovations in target discovery and potential for therapeutic success	3
Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis	3
Potential therapeutic targets for Mpox: the evidence to date	3
Neuropathogenesis of HIV and emerging therapeutic targets	3
H3K27-altered diffuse midline glioma: a paradigm shifting opportunity in direct delivery of targeted therapeutics	3
Refining targeted therapeutic approaches in pancreatic cancer: from histology and molecular pathology to the clinic	3
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath	3
Parasite and host kinases as targets for antimalarials	3
High levels of HDAC expression correlate with microglial aging	3
BRCA mutations in pancreatic cancer and progress in their targeting	3
The case for complement component 5 as a target in neurodegenerative disease	3
Emerging pharmacologic interventions for pre-eclampsia treatment	3
Alternative antigen to defuse SARS-CoV-2 delta variant and its ensuing evolutionary lineage	3
Emerging therapeutic targets for cardiac hypertrophy	3
Type 1 diabetes: key drug targets and how they could influence future therapeutics	3
Correspondence regarding: TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2	3
Neuromodulatory effects of SARS-CoV2 infection: Possible therapeutic targets	3
Targeting protein clearance pathways in GBA1-associated Parkinson disease	3