OOIR: Observatory of International Research

Papers

(The TQCC of BMC Biotechnology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Optimization of chemical transfection in airway epithelial cell lines	66
MiR-125b-5p ameliorates ox-LDL-induced vascular endothelial cell dysfunction by negatively regulating TNFSF4/TLR4/NF-κB signaling	61
Early osteogenic differentiation of human dental stem cells by gelatin/calcium phosphate- Punica granatum nanocomposite scaffold	43
HPV16 mutant E6/E7 construct is protective in mouse model	34
Enhancing the biotransformation of progesterone to the anticancer compound testololactone by Penicillium chrysogenum Ras3009: kinetic modelling and efficiency maximization	30
In vitro evaluation of PLGA loaded hesperidin on colorectal cancer cell lines: an insight into nano delivery system	28
High-performance internal circulation anaerobic granular sludge reactor for cattle slaughterhouse wastewater treatment and simultaneous biogas production	26
Strain-specific features of Pleurotus ostreatus growth in vitro and some of its biological activities	25
Toxic effects of trace phenol/guanidine isothiocyanate (P/GI) on cells cultured nearby in covered 96-well plates	25
Validation of a rapid collagenase activity detection technique based on fluorescent quenched gelatin with synovial fluid samples	22
Development of a CHO cell line for stable production of recombinant antibodies against human MMP9	21
Aspergillus terreus camptothecin-sodium alginate/titanium dioxide nanoparticles as a novel nanocomposite with enhanced compatibility and anticancer efficiency in vivo	21
Development of a chemiluminescent immunoassay based on magnetic solid phase for quantification of homocysteine in human serum	19
Establishment of a novel cell line for producing replication-competent adenovirus-free adenoviruses	19
Metabolic engineering of energycane to hyperaccumulate lipids in vegetative biomass	19
Activating the healing process: three-dimensional culture of stem cells in Matrigel for tissue repair	18
An efficient and specific CRISPR-Cas9 genome editing system targeting soybean phytoene desaturase genes	17
Deep orange gene editing triggers temperature-sensitive lethal phenotypes in Ceratitis capitata	17
Extraction and analysis of high-quality chloroplast DNA with reduced nuclear DNA for medicinal plants	16
Expression and characterization of recombinant IL-1Ra in Aspergillus oryzae as a system	16
Expansion of targetable sites for the ribonucleoprotein-based CRISPR/Cas9 system in the silkworm Bombyx mori	15
Screening of Candida spp. in wastewater in Brazil during COVID-19 pandemic: workflow for monitoring fungal pathogens	14
Simplified cloning and isolation of peptides from “sandwiched” SUMO-peptide-intein fusion proteins	14
Development of a thrombin-antithrombin complex detection kit and study in venous thromboembolism complicated by cervical cancer	13
Analysis of conventional and alternative CRISPR/Cas9 genome editing to enhance a single-base pair knock-in mutation	12

Improvement and prediction of the extraction parameters of lupeol and stigmasterol metabolites of Melia azedarach with response surface methodology	11
Antimicrobial and cytotoxic activities of flavonoid and phenolics extracted from Sepia pharaonis ink (Mollusca: Cephalopoda)	11
Designing, optimization, and validation of whole blood direct T-ARMS PCR for precise and rapid genotyping of complex vertebral malformation in cattle	11
A nano-Liposomal formulation potentiates antioxidant, anti-inflammatory, and fibrinolytic activities of Allolobophora caliginosa coelomic fluid: formulation and characterization	11
Optimization of expression, purification and secretion of functional recombinant human growth hormone in Escherichia coli using modified staphylococcal protein a signal peptide	11
Identification of a novel fully human anti-toxic shock syndrome toxin (TSST)-1 single-chain variable fragment antibody averting TSST-1-induced mitogenesis and cytokine secretion	11
Genome-scale model reconstruction of the methylotrophic yeast Ogataea polymorpha	11
Efficient expression of fusion human epidermal growth factor in tobacco chloroplasts	11
Fabrication of apigenin and adenosine-loaded nanoparticles against doxorubicin-induced myocardial infarction by reducing inflammation and oxidative stress	10
Screening approaches and potential of isolated lactic acid bacteria for improving fermentation of Saccharina latissima	10
Comparison of lipidome profiles in serum from lactating dairy cows supplemented with Acremonium terrestris culture based on UPLC-QTRAP-MS/MS	10
Fertility protective effects of Brillantaisia patula leaf extract against cyclophosphamide-induced ovarian damage in Wistar rats	10
Levan from Leuconostoc citreum BD1707: production optimization and changes in molecular weight distribution during cultivation	10
Characterization, modeling, and anticancer activity of L.arginase production from marine Bacillus licheniformis OF2	10
Evaluating the impact of Cold plasma on Seedling Growth properties, seed germination, and soybean antioxidant enzyme activity	10
Engineered FGF19ΔKLB protects against intrahepatic cholestatic liver injury in ANIT-induced and Mdr2-/- mice model	10
Green and environmentally friendly synthesis of silver nanoparticles with antibacterial properties from some medicinal plants	10
A novel starch-active lytic polysaccharide monooxygenase discovered with bioinformatics screening and its application in textile desizing	9
Transcriptomic and targeted metabolomic analyses provide insights into the flavonoids biosynthesis in the flowers of Lonicera macranthoides	9
Synergistic effect of zinc oxide-cinnamic acid nanoparticles for wound healing management: in vitro and zebrafish model studies	9
Chemical and Heat Treatment for Viral Inactivation in Porcine-Derived Gelatin	9
Black glucose-releasing silicon elastomer rings for fed-batch operation allow measurement of the oxygen transfer rate from the top and optical signals from the bottom for each well of a microtiter pla	9
A simplified Gibson assembly method for site directed mutagenesis by re-use of standard, and entirely complementary, mutagenesis primers	8
Rescue of an enterotropic Newcastle disease virus strain ZM10 from cloned cDNA and stable expressing an inserted foreign gene	8
Insights from molecular docking and molecular dynamics on the potential of vitexin as an antagonist candidate against lipopolysaccharide (LPS) for microglial activation in neuroinflammation	8
Comparative evaluation of different molecular methods for DNA extraction from individual Teladorsagia circumcincta nematodes	8
Modification of improved-genome editing via oviductal nucleic acids delivery (i-GONAD)-mediated knock-in in rats	8
Development of a microbial protease for composting swine carcasses, optimization of its production and elucidation of its catalytic hydrolysis mechanism	8
Improving the regeneration rate of deep lethal mutant protoplasts by fusion to promote efficient L-lysine fermentation	8
Efficient gene delivery into the embryonic chicken brain using neuron-specific promoters and in ovo electroporation	7
Modeling and optimizing in vitro percentage and speed callus induction of carrot via Multilayer Perceptron-Single point discrete GA and radial basis function	7
Determination of serum CA724 levels using fluorescence immunochromatography	7
Development of Virus-Like Particles (VLPs) for Hepatitis C Virus genotype 4: a novel approach for vaccine development in Egypt	7
Repurposing novel therapeutic candidate drugs for coronavirus disease-19 based on protein-protein interaction network analysis	7
αvβ3-targeted sEVs for efficient intracellular delivery of proteins using MFG-E8	7
Biocompatibility and potential anticancer activity of gadolinium oxide (Gd2O3) nanoparticles against nasal squamous cell carcinoma	7
In vitro assessment of the effect of magnetic fields on efficacy of biosynthesized selenium nanoparticles by Alborzia kermanshahica	6
Generation of genome-edited dogs by somatic cell nuclear transfer	6
Reductive enzymatic dynamic kinetic resolution affording 115 g/L (S)-2-phenylpropanol	6
Enzymatic degradation is an effective means to reduce aflatoxin contamination in maize	6
Solubility of lamotrigine in age-specific biorelevant media that simulated the fasted- and fed-conditions of the gastric and intestinal environments in pediatrics and adults: implications for traditio	6
Evaluating the biocontrol potential of Canadian strain Bacillus velezensis 1B-23 via its surfactin production at various pHs and temperatures	6
3D printing of Ceffe-infused scaffolds for tailored nipple-like cartilage development	5
The feasibility of sodium hydroxide pretreatment of rice straw for solid substrate preparation to enhance laccase production by solid state fermentation	5
Correction to: Failure to maintain full-term pregnancies in pig carrying klotho monoallelic knockout fetuses	5
Exploring the microbial diversity and characterization of cellulase and hemicellulase genes in goat rumen: a metagenomic approach	5
Systematic design and evaluation of aptamers for VEGF and PlGF biomarkers of Preeclampsia	5
Biochemical characterization of specific Alanine Decarboxylase (AlaDC) and its ancestral enzyme Serine Decarboxylase (SDC) in tea plants (Camellia sinensis)	5
The mechanism of degradation of alizarin red by a white-rot fungus Trametes gibbosa	5
Coupling fermentation of glutamic acid and γ-polyglutamic acid and preparation of poly(amino acid) superabsorbent polymers	5

Synthesis and evaluation of nanosized aluminum MOF encapsulating Umbelliferon: assessing antioxidant, anti-inflammatory, and wound healing potential in an earthworm model	5
Impact of media components from different suppliers on enterokinase productivity in Pichia pastoris	5
An improved HPAEC-PAD method for the determination of D-glucuronic acid and 4-O-methyl-D-glucuronic acid from polymeric and oligomeric xylan	5
Antibacterial, antibiofilm, and anticancer activity of silver-nanoparticles synthesized from the cell-filtrate of Streptomyces enissocaesilis	5