OOIR: Observatory of International Research

Papers

(The TQCC of BMC Biotechnology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Efficient removal of Congo Red Dye using a MgAl-LDH/cuttlebone composite adsorbent	62
Parabacteroides distasonis promotes CXCL9 secretion of tumor-associated macrophages and enhances CD8+T cell activity to trigger anti-tumor immunity against anti-PD-1 treatment in non-small cell lung c	53
Simplified cloning and isolation of peptides from “sandwiched” SUMO-peptide-intein fusion proteins	47
Identification of a novel fully human anti-toxic shock syndrome toxin (TSST)-1 single-chain variable fragment antibody averting TSST-1-induced mitogenesis and cytokine secretion	45
A novel single-vector featuring bidirectional promoters for production of bispecific antibody against rabies virus	36
Improvement and prediction of the extraction parameters of lupeol and stigmasterol metabolites of Melia azedarach with response surface methodology	35
Optimized zymogram protocol from 3D spheroid cultures to study MMP-2 and -9 activities in tumor cells	33
N-terminal truncation of the foot-and-mouth disease virus VP0 protein promotes soluble co-expression and particle assembly stability of viral capsid proteins in Escherichia coli	31
Maximizing lipid accumulation in Tetradesmus obliquus under heavy metal stress for sustainable biodiesel innovation	29
Gellan gum/gelatin Schiff-base hydrogel for ocular drug delivery of timolol maleate	27
Enzymatic degradation is an effective means to reduce aflatoxin contamination in maize	25
Biosafety and pharmacokinetic characteristics of polyethylene pyrrolidone modified nano selenium in rats	25
3D printing of Ceffe-infused scaffolds for tailored nipple-like cartilage development	24
Biocompatibility and potential anticancer activity of gadolinium oxide (Gd2O3) nanoparticles against nasal squamous cell carcinoma	23
Synergistic effect of zinc oxide-cinnamic acid nanoparticles for wound healing management: in vitro and zebrafish model studies	22
Transgenic Arabidopsis thaliana plants expressing bacterial γ-hexachlorocyclohexane dehydrochlorinase LinA	21
Comparison of vector elements and process conditions in transient and stable suspension HEK293 platforms using SARS-CoV-2 receptor binding domain as a model protein	21
Highly multiplexed targeted sequencing strategy for infectious disease surveillance	21
Rice yellow mottle virus is a suitable amplicon vector for an efficient production of an anti-leishmianiasis vaccine in Nicotiana benthamiana leaves	20
Fusarium verticillioides pigment: production, response surface optimization, gamma irradiation and encapsulation studies	19
The ESRP1 promoter reporter can function as an in vivo sensor of DNA methyltransferase inhibition	19
Electrospun PCL membranes for localized drug delivery and bone regeneration	19
Evaluating the anticancer efficacy of Chara vulgaris ethanolic extract and selenium nanoformulation in Ehrlich carcinoma mice: role of autophagy and apoptosis	19
Fabrication and characterization of metformin-loaded PLGA/Collagen nanofibers for modulation of macrophage polarization for tissue engineering and regenerative medicine	19
Generation of a recombinant antibody for sensitive detection of Pseudomonas aeruginosa	18

Biochemical characterization and insights into the potency of the acidic Aspergillus niger NRC114 purified α-galactosidase in removing raffinose family oligosaccharides from soymilk yogurt	18
FOXD1, a hypoxia-related gene, accelerates prostate cancer cell growth by increasing glycolysis under hypoxia conditions	17
One-step fermentation for producing xylo-oligosaccharides from wheat bran by recombinant Escherichia coli containing an alkaline xylanase	16
Soft sensor modeling method for Pichia pastoris fermentation process based on substructure domain transfer learning	15
Purification and characterization of soluble recombinant Crimean-Congo hemorrhagic fever virus glycoprotein Gc expressed in mammalian 293F cells	15
Newly designed curcumin-loaded hybrid nanoparticles: a multifunctional strategy for combating oxidative stress, inflammation, and infections to accelerate wound healing and tissue regeneration	14
A new mRNA structure prediction based approach to identifying improved signal peptides for bone morphogenetic protein 2	14
Anti-inflammatory potential of aspergillus unguis SP51-EGY: TLR4-dependent effects & chemical diversity via Q-TOF LC-HRMS	14
Chitosan nano-formulation enhances stability and bactericidal activity of the lytic phage HK6	14
Isolation and identification of antifungal, antibacterial and nematocide agents from marine bacillus gottheilii MSB1	13
Molecular and agro-morphological characterization of new barley genotypes in arid environments	13
A novel allogeneic acellular matrix scaffold for porcine cartilage regeneration	13
Aripiprazole-loaded niosome/chitosan-gold nanoparticles for breast cancer chemo-photo therapy	13
Gene cloning and molecular characterization of a thermostable chitosanase from Bacillus cereus TY24	13
A critical role for erythropoietin on vagus nerve Schwann cells in intestinal motility	13
Central position of histidine in the sequence of designed alternating polarity peptides enhances pH-responsive assembly with DNA	12
In silico screening and in vitro biological evaluation reveal Queuine as a promising MAP4K4 inhibitor for treating pancreatic cancer	12
A copper switch for inducing CRISPR/Cas9-based transcriptional activation tightly regulates gene expression in Nicotiana benthamiana	12
Protease sensitivity and stress adaptation of bioactive peptide-producing lactic acid bacteria: functional implications for food biopreservation	12
Efficient delivery of a large-size Cas9-EGFP vector in porcine fetal fibroblasts using a Lonza 4D-Nucleofector system	11
A magnetic solid phase chemiluminescent immunoassay for quantification of Cystatin C in human serum	11
Saccharification and co-fermentation of lignocellulosic biomass by a cockroach-gut bacterial symbiont and yeast cocktail for bioethanol production	11
Unlocking the antioxidant and antibacterial potential of exopolysaccharides produced by endophytic fungi (Aspergillus fumigatus and Preussia isabellae) isolated from Tanzania’s mangroves	11
Validation and calibration of a novel GEM biosensor for specific detection of Cd2+, Zn2+, and Pb2+	11
An engineered hypoxia-response promoter for human umbilical cord-derived mesenchymal stem cell-based therapeutics	11
ECM-mimetic, NSAIDs loaded thermo-responsive, immunomodulatory hydrogel for rheumatoid arthritis treatment	11
Improvements of gamma radiation-induced immunological, hematological, and some biochemical changes in male albino rats by custard apple (Annona squamosa) seed oil extract	10
Dexamethasone-boosted mesenchymal stem cell secretome: insight into hepatic protection	10
Derivation of a novel antimicrobial peptide from the Red Sea Brine Pools modified to enhance its anticancer activity against U2OS cells	10
Ferula latisecta gels for synthesis of zinc/silver binary nanoparticles: antibacterial effects against gram-negative and gram-positive bacteria and physicochemical characteristics	10
Aspergillus terreus camptothecin-sodium alginate/titanium dioxide nanoparticles as a novel nanocomposite with enhanced compatibility and anticancer efficiency in vivo	10
Enhancing the biotransformation of progesterone to the anticancer compound testololactone by Penicillium chrysogenum Ras3009: kinetic modelling and efficiency maximization	9
Establishment of an indirect ELISA antibody detection method based on the stable expression of LSDV P32 protein in CHO-K1 cells	9
An anti-idiotypic single domain antibody as Cry2Aa toxin mimotope and analysis of its binding region through molecular docking	9
High-performance internal circulation anaerobic granular sludge reactor for cattle slaughterhouse wastewater treatment and simultaneous biogas production	9
Fabrication of apigenin and adenosine-loaded nanoparticles against doxorubicin-induced myocardial infarction by reducing inflammation and oxidative stress	9
Rescue of an enterotropic Newcastle disease virus strain ZM10 from cloned cDNA and stable expressing an inserted foreign gene	9
Green and environmentally friendly synthesis of silver nanoparticles with antibacterial properties from some medicinal plants	9
An efficient and specific CRISPR-Cas9 genome editing system targeting soybean phytoene desaturase genes	9
Development of a CHO cell line for stable production of recombinant antibodies against human MMP9	9
Organosolv-derived lipids from hemicellulose and cellulose, and pre-extracted tannins as additives upon hydrothermal liquefaction (HTL) of spruce bark lignins to bio-oil	9
Utilizing non-clonal CHO cell derived materials for preclinical studies of complex molecules	8
Assessment of the bioactive compounds in gamma irradiated stevia (Stevia rebaudiana Bertoni) leaves	8
A novel starch-active lytic polysaccharide monooxygenase discovered with bioinformatics screening and its application in textile desizing	8
Synthesis and evaluation of nanosized aluminum MOF encapsulating Umbelliferon: assessing antioxidant, anti-inflammatory, and wound healing potential in an earthworm model	8
Exploring the microbial diversity and characterization of cellulase and hemicellulase genes in goat rumen: a metagenomic approach	8
Antifungal efficacy of Citrusfusion mediated silver nanoparticles in Candida species	8
Coupling fermentation of glutamic acid and γ-polyglutamic acid and preparation of poly(amino acid) superabsorbent polymers	8
Efficient extraction and antioxidant activity of polyphenols from Antrodia cinnamomea	8
Introduction of loxP sites by electroporation in the mouse genome; a simple approach for conditional allele generation in complex targeting loci	7

Assessment of biochar filter application in improving chromium stress tolerance and plant physiology in Chinese cabbage (Brassica rapa) under a flow-through water setup	7
Enhanced extracellular production of Coprinopsis cinerea laccase Lcc9 in Aspergillus niger by gene expression cassette and bioprocess optimization	7
Comparison of active site mutations at subsite + 2 of Anoxybacillus ayderensis A9 β-glucosidase for hydrolysis of pNPG and polydatin	7
Development of a chemically defined medium for Paenibacillus polymyxa by parallel online monitoring of the respiration activity in microtiter plates	7
Metabolomics-based analysis of the correlation between lipid metabolites and thyroid carcinoma	7
Influence of low-intensity artificial light on the fatty acid profile of the biotechnologically important culinary mushroom Pleurotus eryngii in vitro	7
Development of a chemiluminescence assay for tissue plasminogen activator inhibitor complex and its applicability to gastric cancer	7
Dual release of daptomycin and BMP-2 from a composite of β-TCP ceramic and ADA gelatin	7
Integration of ZnO nanorods with silver ions by a facile co-precipitation for antimicrobial, larvicidal, and ovicidal activity	7
Oleic acid based experimental evolution of Bacillus megaterium yielding an enhanced P450 BM3 variant	7
Optimization of culture conditions for HBV-specific T cell expansion in vitro from chronically infected patients	7
Bioconversion of wild Ipomoea pes-caprae and Suaeda fruticosa biomass: a novel application of thermostable xylanase from Neobacillus sedimentimangrovi	7
Prediction and optimization of indirect shoot regeneration of Passiflora caerulea using machine learning and optimization algorithms	7
Choosing an appropriate somatic embryogenesis medium of carrot (Daucus carota L.) by data mining technology	7
rocF affects the production of tetramethylpyrazine in fermented soybeans with Bacillus subtilis BJ3-2	7
The transcriptional factor Clr-5 is involved in cellulose degradation through regulation of amino acid metabolism in Neurospora crassa	7
Orange peel-mediated synthesis of silver nanoparticles with antioxidant and antitumor activities	7
An engineered self-cleavage fusion system for the production of chimaera spider silk proteins	7
Effects of solid lipid nanocarrier containing methyl urolithin A by coating folate-bound chitosan and evaluation of its anti-cancer activity	7
Scientific and technological challenges of recombinant egg protein production	7