OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Molecular Medicine is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Subscription and Copyright Information	227
Advisory Board and Contents	206
Subscription and Copyright Information	196
Subscription and Copyright Information	163
Advisory Board and Contents	160
Subscription and Copyright Information	154
Advisory Board and Contents	132
Subscription and Copyright Information	124
Stories in Molecular Medicine December 2021	124
Advisory Board and Contents	120
Consideration of the importance of measuring thermal discomfort in biomedical research	113
Beneath the radar: immune-evasive cell sources for stroke therapy	108
Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes	103
Opportunities and challenges for biomarker discovery using electronic health record data	103
Pushing the boundaries of brain organoids to study Alzheimer’s disease	96
Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates	95
Neutrophils and extracellular traps in crystal-associated diseases	91
m6A and beyond: RNA modifications shaping angiogenesis	91
Fc-optimized checkpoint antibodies for cancer immunotherapy	85
Bursts of brain erosion: seizures and age-dependent neurological vulnerability	79
Cellular senescence in neuroinflammatory disease: new therapies for old cells?	78
d-Amino acids: new clinical pathways for brain diseases	77
Subscription and Copyright Information	72
Advancements in intensive eating disorder treatments: the benefit of CBT-E and integrated care models	70
Stories in Molecular Medicine November 2021	69

RNA immunotherapy: revolutionizing cancer and autoimmune disease treatments	67
Keratinocytes: new perspectives in inflammatory skin diseases	66
Microbes and mood: innovative biomarker approaches in depression	65
Cell-free circulating tumor DNA profiling in cancer management	64
Acquired resistance to immunotherapy in solid tumors	64
Brain-specific regulatory T cell expansion limits cognitive decline	61
Systemically administered alcadein peptide p3-Alcβ neutralizes brain Alzheimer’s Aβ oligomers	59
Insights from HIV-1 vaccine and passive immunization efficacy trials	58
Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality	54
Advisory Board and Contents	54
iPSCs and DRGs: stepping stones to new pain therapies	53
Three ‘E’ challenges for siRNA drug development	52
Amyloid and collagen templates in aortic valve calcification	52
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients	51
Emerging roles of cyclin-dependent kinase 7 in health and diseases	51
Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging	51
Erythropoietic protoporphyrias: updates and advances	48
Epigenetic regulation in intervertebral disc degeneration	46
Engineering cytokines for tumor-targeting and selective T cell activation	46
Hormesis as an adaptive response to infection	46
Molecular mechanisms in the pathogenesis of dengue infections	46
Significant challenges to translating breakthrough science in Mexico	44
Promoting proteostasis by cAMP/PKA and cGMP/PKG	44
Pathogenic mechanisms in genetically defined Ehlers–Danlos syndromes	43
Roadmap for developing biologically inspired therapeutics for genetic brain disorders	42
Advisory Board and Contents	42
Leptin and male fertility: unraveling the molecular pathways, receptor functions, and therapeutic potential	42
Subscription and Copyright Information	42
Advisory Board and Contents	42
Shining a light on comorbidities	42
Mitigating age-related somatic mutation burden	39
Subscription and Copyright Information	39
SOX17: escape route from immune destruction in early CRC	39
The endoplasmic reticulum proteostasis network and bone disease	38
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation	38
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart	38
Antibody signatures in inflammatory bowel disease: current developments and future applications	38
CircRNA perspective: new strategies for RNA therapy	37
Clinical implications of vitamin B12 as redox-active cofactor	37
Science around the world	36
Subscription and Copyright Information	36
The bleeding edge: broadening horizons for hematopoietic stem cell therapies	35
Focused ultrasound gene delivery for the treatment of neurological disorders	35
Naked mole-rats: at the heart of it	34
Saving eyesight, one gene at a time	34
Two-pronged immune evasion of pseudouridine-modified RNA	34
Translation of gene therapy strategies for amyotrophic lateral sclerosis	34
Targeting mitochondrial transfer as a promising therapeutic strategy	33
Molecular disease mechanisms of human antineuronal monoclonal autoantibodies	32
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	32

Time-restricted feeding and Alzheimer’s disease: you are when you eat	32
Intestinal mucus barrier: a missing piece of the puzzle in food allergy	31
Maternal obesity: new placental paradigms unfolded	31
Skin senescence: mechanisms and impact on whole-body aging	30
The emerging Janus face of SVEP1 in development and disease	30
IL-15 in CAR engineering: striking an efficacy–safety balance	29
Advisory Board and Contents	29
Advisory Board and Contents	28
Science around the world	28
Incorporating placental pathology into clinical care and research	28
Biodiversity: the overlooked source of human health	27
Cystic fibrosis at a glance: from disease mechanism to therapy	27
Clock-modulated checkpoints in time-restricted eating	27
Leveraging zebrafish to investigate pancreatic development, regeneration, and diabetes	26
Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery	26
Unraveling host genetics and microbiome genome crosstalk: a novel therapeutic approach	26
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health	26
Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer	25
Gasdermins in pyroptosis, inflammation, and cancer	25
Fibroblasts in AKI: small army, big help	25
Advisory Board and Contents	25
Autoantibodies as drivers of neuropathic pain	25
Translational opportunities emerge from genetic influences on health	25
ABC transporters: human disease and pharmacotherapeutic potential	24
Advisory Board and Contents	24
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes	24
The global human gut microbiome: genes, lifestyles, and diet	24
Leveraging cellular mechano-responsiveness for cancer therapy	24
Molecular basis and clinical implications of HIFs in cardiovascular diseases	23
Subscription and Copyright Information	23
Subscription and Copyright Information	23
Advisory Board and Contents	23
Novel universal vaccines to mitigate emerging avian influenza viruses	23
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	23
iPSC-derived models for anorexia nervosa research	22
Stratum corneum as polymer sheet: concept and cornification processes	22
Dissecting mechanisms of fecal microbiota transplantation efficacy in disease	21
Human dopaminergic system in the exercise-cognition link	21
Circadian molecular clock disruption in chronic pulmonary diseases	21
Subscription and Copyright Information	20
Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias	19
Advisory Board and Contents	19
Subscription and Copyright Information	19
TIM-3 blockade: immune and targeted therapy in DIPG	19
AAV capsid design: A Goldilocks challenge	19
Autoimmune diseases and cardiovascular risk	19
Glycosylation of blood cells during the onset and progression of atherosclerosis and myocardial infarction	19
Vaccine-based immunotherapy and related preclinical models for glioma	19
Understanding the tuberculosis granuloma: the matrix revolutions	18
Advisory Board and Contents	18
Missing links in preeclampsia cell model systems of endothelial dysfunction	18
HPV integration and cervical cancer: a failed evolutionary viral trait	18
Asthma exacerbations: the Achilles heel of asthma care	18
Vitiligo: advances in pathophysiology research and treatment development	18
mRNA vaccine platforms to prevent bacterial infections	18
Deciphering the MYCN-driven metabolic microenvironment of neuroblastoma	18
Staging of Alzheimer’s disease: past, present, and future perspectives	18
There is nothing as inconsistent as the OSFED diagnostic criteria	17
The future of phage therapy in the USA	17
Thymic stroma and TFII-I: towards new targeted therapies	17
Copy number alterations: a catastrophic orchestration of the breast cancer genome	17
Primary cilia shape hallmarks of health and aging	17
Thirty years of molecular medicine: reflections from an academic physician-scientist, 1995–2025	17
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections	16
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases	16
Common mechanisms in pediatric acute liver failure	16
Tertiary lymphoid structures in the central nervous system	16
Treating Niemann-Pick C lysosomal storage: approved and emerging approaches	16
Why we must fight ignorance about COVID-19 vaccines and menstrual cycles	16
Telomere biology disorders: time for moving towards the clinic?	16
Redefining metalloproteases specificity through network proteolysis	16
Extracellular matrix-based cancer targeting	16
Organ-specific aging in the plasma proteome predicts disease	15
Clinical crusade: zosurabalpin's charge against antibiotic resistance	15
Dysfunctional tRNA reprogramming and codon-biased translation in cancer	15
Cancer driver mutations: predictions and reality	15
Treatment and research needs for severe eating disorders: a response to Dr Ayton	15
Advisory Board and Contents	15
Safety of non-replicative and oncolytic replication-selective HSV vectors	15
The dual role of the TSC complex in cancer	15