Trends in Molecular Medicine

Papers
(The TQCC of Trends in Molecular Medicine is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)
ArticleCitations
Clinical crusade: zosurabalpin's charge against antibiotic resistance859189559
COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives417
Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies260
Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response197
Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus197
G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies181
Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies167
Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease163
Impact of the Natural Compound Urolithin A on Health, Disease, and Aging162
Cell-Free DNA and Apoptosis: How Dead Cells Inform About the Living145
Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome139
Ferroptosis in the tumor microenvironment: perspectives for immunotherapy127
Liquid Biopsy of Methylation Biomarkers in Cell-Free DNA123
The Gut Microbiota: Emerging Evidence in Autoimmune Diseases116
Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis102
Reducing Senescent Cell Burden in Aging and Disease98
Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer’s Disease94
Cell-to-Cell Transmission of Tau and α-Synuclein89
Metabolic Pathways That Control Skin Homeostasis and Inflammation89
Enhancers in disease: molecular basis and emerging treatment strategies80
Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases79
Ferroptosis in Parkinson’s disease: glia–neuron crosstalk75
Antibiotic Resistance by Enzymatic Modification of Antibiotic Targets69
Skin senescence: mechanisms and impact on whole-body aging66
COVID-19 in pregnancy: implications for fetal brain development65
Microbiota and sleep: awakening the gut feeling64
Extracellular matrix-based cancer targeting62
NIRF Nanoprobes for Cancer Molecular Imaging: Approaching Clinic62
Transcription Factor Inhibition: Lessons Learned and Emerging Targets62
Missing Pieces to the Endocannabinoid Puzzle59
NMDARs in Cell Survival and Death: Implications in Stroke Pathogenesis and Treatment59
Fertility Preservation: The Challenge of Freezing and Transplanting Ovarian Tissue58
Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation57
The gut vascular barrier: a new player in the gut–liver–brain axis57
Haptoglobin Therapeutics and Compartmentalization of Cell-Free Hemoglobin Toxicity55
Fibroblast Heterogeneity in Wound Healing: Hurdles to Clinical Translation50
Preimplantation Genetic Testing for Aneuploidy – a Castle Built on Sand50
Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective50
Bacterial Peptidoglycan as a Driver of Chronic Brain Inflammation49
Activity-Based Diagnostics: An Emerging Paradigm for Disease Detection and Monitoring49
Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines48
HDL and Reverse Remnant-Cholesterol Transport (RRT): Relevance to Cardiovascular Disease47
Mouth-Watering Results: Clinical Need, Current Approaches, and Future Directions for Salivary Gland Regeneration45
Mitochondria as Therapeutic Targets in Transplantation45
Circular RNA translation: novel protein isoforms and clinical significance44
Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia44
Bacterial Peptidoglycans from Microbiota in Neurodevelopment and Behavior43
Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery43
Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis42
Assessing Toxicity with Human Cell-Based In Vitro Methods42
Homeostatic maintenance of the lymphatic vasculature40
Journey to the Center of the Cell: Tracing the Path of AAV Transduction40
Chemical Chaperones as Novel Drugs for Parkinson’s Disease39
The Ground Zero of Organismal Life and Aging39
FABP4: A New Player in Obesity-Associated Breast Cancer39
Multitissue Multiomics Systems Biology to Dissect Complex Diseases39
Towards Advanced iPSC-based Drug Development for Neurodegenerative Disease37
Tooth Repair and Regeneration: Potential of Dental Stem Cells37
Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment37
Pro-cathepsin D, Prosaposin, and Progranulin: Lysosomal Networks in Parkinsonism36
Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases36
Therapeutic Modulation of RNA Splicing in Malignant and Non-Malignant Disease34
Meet Your Stress Management Professionals: The Endocannabinoids34
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health33
Staging of Alzheimer’s disease: past, present, and future perspectives33
Wound Repair, Scar Formation, and Cancer: Converging on Activin32
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?32
Polyhydroxyalkanoates and their advances for biomedical applications32
The gut microbiome as a biomarker of differential susceptibility to SARS-CoV-232
Leveraging Heterogeneity in Systemic Lupus Erythematosus for New Therapies31
Noncoding RNAs versus Protein Biomarkers in Cardiovascular Disease31
Adeno-Associated Virus Vector for Central Nervous System Gene Therapy30
Extracellular Vesicles and Biomaterial Design: New Therapies for Cardiac Repair30
Translational Neuroendocrinology of Human Skin: Concepts and Perspectives30
Extinguishing the Embers: Targeting AML Metabolism29
PD-L1 regulation revisited: impact on immunotherapeutic strategies29
Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing29
Targeted Avenues for Cancer Treatment: The MEK5–ERK5 Signaling Pathway29
Single extracellular vesicle analysis for early cancer detection28
The Urgency of Justice in Research: Beyond COVID-1928
Emergence of New Disease: How Can Artificial Intelligence Help?27
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections27
Commercialization of Organoids27
Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation27
CRISPR Diagnosis and Therapeutics with Single Base Pair Precision27
Data-Driven Modeling of Pregnancy-Related Complications27
JAK–STAT Targeting Offers Novel Therapeutic Opportunities in Sepsis27
Circadian molecular clock disruption in chronic pulmonary diseases26
Type 2 Diabetes Mellitus Drugs for Alzheimer’s Disease: Current Evidence and Therapeutic Opportunities26
Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging26
Editing Cytoprotective Autophagy in Glioma: An Unfulfilled Potential for Therapy26
Intestinal mucus barrier: a missing piece of the puzzle in food allergy26
Organoid models: assessing lung cell fate decisions and disease responses24
Vaccination against Allergy: A Paradigm Shift?24
Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?24
Clinical Potential of Kisspeptin in Reproductive Health24
AAV capsid design: A Goldilocks challenge24
Cancer Surgery 2.0: Guidance by Real-Time Molecular Technologies24
The Centrosome Linker and Its Role in Cancer and Genetic Disorders24
Influenza A Viruses: Understanding Human Host Determinants24
It’s in Our Blood: A Glimpse of Personalized Medicine23
TLR2 as a Therapeutic Target in Bacterial Infection23
The physiology of bilirubin: health and disease equilibrium23
Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors23
The COVID-19 Pandemic from an Ophthalmologist’s Perspective23
Can’t handle the stress? Mechanobiology and disease22
Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology22
PD-L1 and B7-1 Cis-Interaction: New Mechanisms in Immune Checkpoints and Immunotherapies22
Therapeutic Approaches in Facioscapulohumeral Muscular Dystrophy22
Considering the Immune System during Fecal Microbiota Transplantation for Clostridioides difficile Infection22
Microbe–MUC1 Crosstalk in Cancer-Associated Infections22
Sirtuins: To Be or Not To Be in Diabetic Cardiomyopathy21
Therapeutic potential of interleukin-2 in autoimmune diseases21
Molecular pathology of rare progeroid diseases21
T Cells as Guardians of Pain Resolution21
Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging20
Topical Microbial Therapeutics against Respiratory Viral Infections20
First Trial of CRISPR-Edited T cells in Lung Cancer20
Breakthroughs and bottlenecks in autophagy research20
Genetic and Genomic Mechanisms of Primary Aldosteronism20
Strategies of pluripotent stem cell-based therapy for retinal degeneration: update and challenges20
Exposing the role of metals in neurological disorders: a focus on manganese19
Organoid technologies for the study of intestinal microbiota–host interactions19
Post-Transcriptional Regulation in Skeletal Muscle Development, Repair, and Disease19
Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance18
Mislocalisation of Activated Receptor Tyrosine Kinases – Challenges for Cancer Therapy18
mRNA therapeutics: beyond vaccine applications18
Role and therapeutic implications of protein glycosylation in neuroinflammation18
Treatment and Prevention of Neurocristopathies18
Breakthroughs and Bottlenecks in Microbiome Research18
The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis17
Historical Perspective of Clinical Nano and Microparticle Formulations for Delivery of Therapeutics17
Adolescent PCOS: a postpubertal central obesity syndrome17
Targeting synaptic plasticity in schizophrenia: insights from genomic studies17
A map of the altered glioma metabolism17
Predicting and Overcoming Taxane Chemoresistance16
Ectopic Lymphoid Organs and Immune-Mediated Diseases: Molecular Basis for Pharmacological Approaches16
IBD disease-modifying therapies: insights from emerging therapeutics16
Blocking Signalopathic Events to Treat Cerebral Cavernous Malformations16
Redefining Microglial Identity in Health and Disease at Single-Cell Resolution16
Linking liver metabolic and vascular disease via bile acid signaling16
Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines16
Harnessing Therapeutic IgE Antibodies to Re-educate Macrophages against Cancer16
Role of inflammasomes in HIV-1 infection and treatment16
New insights into vitamin K biology with relevance to cancer16
Moyamoya disease emerging as an immune-related angiopathy16
Bridging rapid and sustained antidepressant effects of ketamine16
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