Trends in Molecular Medicine

Article	Citations
Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies	319
Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease	204
G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies	200
Impact of the Natural Compound Urolithin A on Health, Disease, and Aging	199
Ferroptosis in the tumor microenvironment: perspectives for immunotherapy	170
Liquid Biopsy of Methylation Biomarkers in Cell-Free DNA	160
Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome	159
Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis	132
The Gut Microbiota: Emerging Evidence in Autoimmune Diseases	129
Ferroptosis in Parkinson’s disease: glia–neuron crosstalk	119
Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer’s Disease	116
Skin senescence: mechanisms and impact on whole-body aging	111
Metabolic Pathways That Control Skin Homeostasis and Inflammation	106
Enhancers in disease: molecular basis and emerging treatment strategies	105
Cell-to-Cell Transmission of Tau and α-Synuclein	100
Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases	92
COVID-19 in pregnancy: implications for fetal brain development	85
The gut vascular barrier: a new player in the gut–liver–brain axis	80
Microbiota and sleep: awakening the gut feeling	79
Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation	76
Extracellular matrix-based cancer targeting	76
Fertility Preservation: The Challenge of Freezing and Transplanting Ovarian Tissue	71
Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment	70
Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines	62
Preimplantation Genetic Testing for Aneuploidy – a Castle Built on Sand	61

Circular RNA translation: novel protein isoforms and clinical significance	59
Fibroblast Heterogeneity in Wound Healing: Hurdles to Clinical Translation	58
HDL and Reverse Remnant-Cholesterol Transport (RRT): Relevance to Cardiovascular Disease	56
Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery	55
Tooth Repair and Regeneration: Potential of Dental Stem Cells	54
The Ground Zero of Organismal Life and Aging	52
FSP1: a key regulator of ferroptosis	51
Mitochondria as Therapeutic Targets in Transplantation	51
Journey to the Center of the Cell: Tracing the Path of AAV Transduction	50
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health	49
Polyhydroxyalkanoates and their advances for biomedical applications	48
Towards Advanced iPSC-based Drug Development for Neurodegenerative Disease	47
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?	46
Homeostatic maintenance of the lymphatic vasculature	46
Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis	46
Leveraging Heterogeneity in Systemic Lupus Erythematosus for New Therapies	44
Staging of Alzheimer’s disease: past, present, and future perspectives	44
Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia	44
Single extracellular vesicle analysis for early cancer detection	43
The physiology of bilirubin: health and disease equilibrium	41
Therapeutic Modulation of RNA Splicing in Malignant and Non-Malignant Disease	41
Pro-cathepsin D, Prosaposin, and Progranulin: Lysosomal Networks in Parkinsonism	40
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections	39
IBD disease-modifying therapies: insights from emerging therapeutics	38
Adeno-Associated Virus Vector for Central Nervous System Gene Therapy	38
Meet Your Stress Management Professionals: The Endocannabinoids	38
Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases	38
Translational Neuroendocrinology of Human Skin: Concepts and Perspectives	38
JAK–STAT Targeting Offers Novel Therapeutic Opportunities in Sepsis	37
Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing	36
Intestinal mucus barrier: a missing piece of the puzzle in food allergy	36
PD-L1 regulation revisited: impact on immunotherapeutic strategies	35
Wound Repair, Scar Formation, and Cancer: Converging on Activin	35
Cancer driver mutations: predictions and reality	35
Organoid models: assessing lung cell fate decisions and disease responses	34
N6-methyladenosine-mediated gene regulation and therapeutic implications	34
The Urgency of Justice in Research: Beyond COVID-19	34
The gut microbiome as a biomarker of differential susceptibility to SARS-CoV-2	34
Can’t handle the stress? Mechanobiology and disease	32
Extracellular Vesicles and Biomaterial Design: New Therapies for Cardiac Repair	32
Extinguishing the Embers: Targeting AML Metabolism	32
Moyamoya disease emerging as an immune-related angiopathy	32
Adolescent PCOS: a postpubertal central obesity syndrome	32
Cancer Surgery 2.0: Guidance by Real-Time Molecular Technologies	31
Understanding human health through metatranscriptomics	31
AAV capsid design: A Goldilocks challenge	31
Molecular pathology of rare progeroid diseases	30
Circadian molecular clock disruption in chronic pulmonary diseases	30
Data-Driven Modeling of Pregnancy-Related Complications	30
Therapeutic potential of interleukin-2 in autoimmune diseases	30

Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors	30
Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging	29
Clinical Potential of Kisspeptin in Reproductive Health	29
Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation	29
Dysfunctional tRNA reprogramming and codon-biased translation in cancer	28
New insights into vitamin K biology with relevance to cancer	28
ABC transporters: human disease and pharmacotherapeutic potential	27
Strategies of pluripotent stem cell-based therapy for retinal degeneration: update and challenges	27
Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?	27
Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology	26
The global human gut microbiome: genes, lifestyles, and diet	26
Sirtuins: To Be or Not To Be in Diabetic Cardiomyopathy	26
Influenza A Viruses: Understanding Human Host Determinants	25
It’s in Our Blood: A Glimpse of Personalized Medicine	25
PD-L1 and B7-1 Cis-Interaction: New Mechanisms in Immune Checkpoints and Immunotherapies	25
T Cells as Guardians of Pain Resolution	25
Treatment and Prevention of Neurocristopathies	24
Readthrough compounds for nonsense mutations: bridging the translational gap	24
Therapeutic Approaches in Facioscapulohumeral Muscular Dystrophy	24
Organoid technologies for the study of intestinal microbiota–host interactions	24
Role and therapeutic implications of protein glycosylation in neuroinflammation	24
Pulmonary fibrosis: from pathogenesis to clinical decision-making	23
Adenoviruses in medicine: innocuous pathogen, predator, or partner	23
Exposing the role of metals in neurological disorders: a focus on manganese	23
Breakthroughs and Bottlenecks in Microbiome Research	23
Targeting synaptic plasticity in schizophrenia: insights from genomic studies	23
A map of the altered glioma metabolism	22
Multivalent Probes in Molecular Imaging: Reality or Future?	22
Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines	22
Post-Transcriptional Regulation in Skeletal Muscle Development, Repair, and Disease	22
Pathogenic associations between oral and gastrointestinal diseases	22
Genetic and Genomic Mechanisms of Primary Aldosteronism	22
Linking liver metabolic and vascular disease via bile acid signaling	21
Brain gene therapy with Trojan horse lipid nanoparticles	21
Epigenetic regulation in intervertebral disc degeneration	21
The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis	21
Mislocalisation of Activated Receptor Tyrosine Kinases – Challenges for Cancer Therapy	21
Bridging rapid and sustained antidepressant effects of ketamine	21
mRNA therapeutics: beyond vaccine applications	21
Maternal obesity: new placental paradigms unfolded	21
Topical Microbial Therapeutics against Respiratory Viral Infections	21
Redefining Microglial Identity in Health and Disease at Single-Cell Resolution	20
Breakthroughs and bottlenecks in autophagy research	20
Historical Perspective of Clinical Nano and Microparticle Formulations for Delivery of Therapeutics	20
Fibroblasts in pancreatic cancer: molecular and clinical perspectives	19
iPSCs and DRGs: stepping stones to new pain therapies	19
Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance	19
Blocking Signalopathic Events to Treat Cerebral Cavernous Malformations	19
Ectopic Lymphoid Organs and Immune-Mediated Diseases: Molecular Basis for Pharmacological Approaches	19
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes	18
How aging impacts vaccine efficacy: known molecular and cellular mechanisms and future directions	18
Molecular Mechanisms and Treatment Options of Nephropathic Cystinosis	18
Predicting and Overcoming Taxane Chemoresistance	18
The spike hypothesis in vaccine-induced adverse effects: questions and answers	18
The ubiquitin–proteasome system in breast cancer	18
Clock-modulated checkpoints in time-restricted eating	18
COVID-19 vaccines in pregnancy	18
Organoids, Where We Stand and Where We Go	17
Role of inflammasomes in HIV-1 infection and treatment	17
Stratum corneum as polymer sheet: concept and cornification processes	17
Unlocking the potential of agonist antibodies for treating cancer using antibody engineering	17
Mining Helminths for Novel Therapeutics	17
Nutrition interventions in congenital disorders of glycosylation	16
ERα in the Control of Mitochondrial Function and Metabolic Health	16
CircRNA perspective: new strategies for RNA therapy	16
Cellular senescence in neuroinflammatory disease: new therapies for old cells?	16
DNA Damage Repair Deficiency and Synthetic Lethality for Cancer Treatment	16
Nasal vaccines: solutions for respiratory infectious diseases	16
Future medicine: from molecular pathways to the collective intelligence of the body	16
The NRF2/Keap1 pathway as a therapeutic target in inflammatory bowel disease	16
Unleashing cell-penetrating peptide applications for immunotherapy	16
Molecular disease mechanisms of human antineuronal monoclonal autoantibodies	16
CGRP Receptor Antagonism in COVID-19: Potential Cardiopulmonary Adverse Effects	16
Particulate matter and Alzheimer’s disease: an intimate connection	16
Dietary interventions and precision nutrition in cancer therapy	16
In Utero Gene Therapy: Progress and Challenges	15
PIK3CA-related overgrowth: silver bullets from the cancer arsenal?	15
Cell-free circulating tumor DNA profiling in cancer management	15
Resilience to Stress and Resilience to Pain: Lessons from Molecular Neurobiology and Genetics	15
Understanding the tuberculosis granuloma: the matrix revolutions	15

Erythrophagocytes in hemolytic anemia, wound healing, and cancer	14
Microglia–T cell conversations in brain cancer progression	14
Advances in Inflammasome Research: Recent Breakthroughs and Future Hurdles	14
The microbiome, guard or threat to infant health	14
ROS/RNS as molecular signatures of chronic liver diseases	14
siRNA modification and delivery for drug development	14
Developing Novel Tests to Screen for Fetal Growth Restriction	14
Deciphering the Identity of Renin Cells in Health and Disease	14
Polycystic kidney disease: novel insights into polycystin function	13
Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease	13
Pushing the boundaries of brain organoids to study Alzheimer’s disease	13
Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates	13
NK cells in the brain: implications for brain tumor development and therapy	13
Rejuvenating the human gut microbiome	13
Meeting the needs of patients with ultrarare diseases	13
Biodiversity: the overlooked source of human health	13
Environmental perception and control of gastrointestinal immunity by the enteric nervous system	13
Recent insights into lysosomal acid lipase deficiency	12
Biological principles of adult degenerative scoliosis	12
d-Amino acids: new clinical pathways for brain diseases	12
Molecular basis and clinical implications of HIFs in cardiovascular diseases	12
Methodological considerations for circulating long noncoding RNA quantification	12
A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes	12
Therapeutic Opportunities for Repair GPCRs during Intestinal Mucosal Wound Healing	11
Cutaneous neuroimmune crosstalk in pruritus	11
Modeling glioblastoma complexity with organoids for personalized treatments	11
A call for disability health curricula in medical schools	11
The variant landscape and function of DDX3X in cancer and neurodevelopmental disorders	11
Choroideremia: molecular mechanisms and therapies	11
Antibody signatures in inflammatory bowel disease: current developments and future applications	11
Clinical implications of vitamin B12 as redox-active cofactor	10
Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies	10
Updates and advances in pyruvate kinase deficiency	10
Nerve–stem cell crosstalk in skin regeneration and diseases	10
Immunogenicity of SARS-CoV-2 vaccines in patients with cancer	10
PRDM12: New Opportunity in Pain Research	10
Strategies to Identify Genetic Variants Causing Infertility	10
The sense of antisense therapies in ALS	10
Medical education empowered by generative artificial intelligence large language models	10
Secondary failure: immune responses to approved protein therapeutics	10
Drug Discovery Inspired from Nuclear Receptor Sensing of Microbial Signals	10
Targeting ACC for NASH resolution	10
Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery	10
Omaveloxolone: a groundbreaking milestone as the first FDA-approved drug for Friedreich ataxia	10
Ubiquitin-modifying enzymes as regulators of colitis	10
Cellular Models and High-Throughput Screening for Genetic Causality of Intellectual Disability	10
Leveraging cellular mechano-responsiveness for cancer therapy	9
Acting on ethics and governance of aging research	9
Oligodendrocyte pathology in Huntington’s disease: from mechanisms to therapeutics	9
Control of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Cancer	9
Immunobiology of pregnancy: from basic science to translational medicine	9
AMPK is mitochondrial medicine for neuromuscular disorders	9
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart	9
Epigenetic priming in neurodevelopmental disorders	9
Microbiome-targeted interventions for the control of oral–gut dysbiosis and chronic systemic inflammation	9
IL-33–ILC2 axis in the female reproductive tract	9
Integrating single-cell genomics pipelines to discover mechanisms of stem cell differentiation	9
Three ‘E’ challenges for siRNA drug development	9
Translating osteoarthritis genetics research: challenging times ahead	9
Gene-based delivery of immune-activating cytokines for cancer treatment	8
Human autophagy measurement: an underappreciated barrier to translation	8
AAV-Mediated Gene Therapy for Glycosphingolipid Biosynthesis Deficiencies	8
Optical Coherence Tomography Angiography: A Window into Central Nervous System Neurodegeneration	8
Cell-based regenerative medicine for renovascular disease	8
Transmission of Polycystic Ovary Syndrome via Epigenetic Inheritance	8
Compartmentalization and regulation of GTP in control of cellular phenotypes	8
Novel Therapies for Pneumonia-Associated Severe Asthma Phenotypes	8
Calpains as mechanistic drivers and therapeutic targets for ocular disease	8
RNA Therapeutics Are Stepping Out of the Maze	8
Telomere biology disorders: time for moving towards the clinic?	8
Transplantation of neural progenitor cells into the human CNS	8
Circadian Angiopoietin-Like-4 as a Novel Therapy in Cardiovascular Disease	7
Mitigating age-related somatic mutation burden	7
Dysfunctional T Cell Mitochondria Lead to Premature Aging	7
Nanobodies as a powerful platform for biomedicine	7
Delivery of therapeutic AAV9 vectors via cisterna magna to treat neurological disorders	7
New strategies for the treatment of chronic hepatitis B	7
Opportunities and challenges for biomarker discovery using electronic health record data	7
Neuronal Reprogramming for Brain Repair: Challenges and Perspectives	7
Focused ultrasound gene delivery for the treatment of neurological disorders	7
Accelerated Approval or Risk Reduction? How Response Biomarkers Advance Therapeutics through Clinical Trials in Cystic Fibrosis	7
Asthma exacerbations: the Achilles heel of asthma care	7
Diabetes: a tipping point in neurodegenerative diseases	6
PARsylation-mediated ubiquitylation: lessons from rare hereditary disease Cherubism	6
Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality	6
A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies	6
Convalescent plasma to deliver therapeutic antibodies against COVID-19	6
ARID1A mutations in lung cancer: biology, prognostic role, and therapeutic implications	6
InFUSing antisense oligonucleotides for treating ALS	6
Monoamines' role in islet cell function and type 2 diabetes risk	6
Engineering Strategies for Allogeneic Solid Tissue Acceptance	6
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation	6
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients	6
Primary cilia shape hallmarks of health and aging	6
Harnessing the healing power of love	6