Trends in Molecular Medicine

Article	Citations
Advisory Board and Contents	269
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Advisory Board and Contents	228
Advisory Board and Contents	170
Subscription and Copyright Information	141
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Fc-optimized checkpoint antibodies for cancer immunotherapy	140
Consideration of the importance of measuring thermal discomfort in biomedical research	137
Cellular senescence in neuroinflammatory disease: new therapies for old cells?	123
Lymph node microenvironment rewires ferroptosis redox defenses	116
Opportunities and challenges for biomarker discovery using electronic health record data	109
Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes	102
Beneath the radar: immune-evasive cell sources for stroke therapy	102
Neutrophils and extracellular traps in crystal-associated diseases	102
m6A and beyond: RNA modifications shaping angiogenesis	96
Microbiota: a dawn for cancer metastasis therapy	96
The right drug at the right time: key to IBD success	93
Muscle-to-CNS signaling in physiological homeostasis, aging, and disease	92
d-Amino acids: new clinical pathways for brain diseases	88
Bursts of brain erosion: seizures and age-dependent neurological vulnerability	86
Systemically administered alcadein peptide p3-Alcβ neutralizes brain Alzheimer’s Aβ oligomers	82
Pushing the boundaries of brain organoids to study Alzheimer’s disease	82
Advisory Board and Contents	82
Brain-specific regulatory T cell expansion limits cognitive decline	81

Erythropoietic protoporphyrias: updates and advances	79
Amyloid and collagen templates in aortic valve calcification	73
Is endometriosis a progressive disease?	73
Hormesis as an adaptive response to infection	71
Advancements in intensive eating disorder treatments: the benefit of CBT-E and integrated care models	66
Insights from HIV-1 vaccine and passive immunization efficacy trials	66
Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality	64
Engineering cytokines for tumor-targeting and selective T cell activation	61
RNA immunotherapy: revolutionizing cancer and autoimmune disease treatments	60
Molecular mechanisms in the pathogenesis of dengue infections	59
Epigenetic regulation in intervertebral disc degeneration	58
Three ‘E’ challenges for siRNA drug development	58
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients	57
Microbes and mood: innovative biomarker approaches in depression	57
Acquired resistance to immunotherapy in solid tumors	57
Emerging roles of cyclin-dependent kinase 7 in health and diseases	56
Keratinocytes: new perspectives in inflammatory skin diseases	56
Mitigating age-related somatic mutation burden	55
Promoting proteostasis by cAMP/PKA and cGMP/PKG	54
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation	54
Tick-borne encephalitis: emerging clinical trends and challenges	53
SOX17: escape route from immune destruction in early CRC	52
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Shining a light on comorbidities	51
Roadmap for developing biologically inspired therapeutics for genetic brain disorders	50
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Leptin and male fertility: unraveling the molecular pathways, receptor functions, and therapeutic potential	46
Significant challenges to translating breakthrough science in Mexico	46
The endoplasmic reticulum proteostasis network and bone disease	45
Overcoming rabies immune evasion via monoclonal antibody therapeutics	45
Antibody signatures in inflammatory bowel disease: current developments and future applications	44
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart	44
Pathogenic mechanisms in genetically defined Ehlers–Danlos syndromes	44
Subscription and Copyright Information	41
Science around the world	41
The bleeding edge: broadening horizons for hematopoietic stem cell therapies	40
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	40
Saving eyesight, one gene at a time	40
Time-restricted feeding and Alzheimer’s disease: you are when you eat	39
Decoding atopic dermatitis: pathophysiology, clinical diagnosis, and treatments	39
Translation of gene therapy strategies for amyotrophic lateral sclerosis	38
Naked mole-rats: at the heart of it	38
Timing matters: maternal milk IgG sets weaning threshold	38
Two-pronged immune evasion of pseudouridine-modified RNA	38
Focused ultrasound gene delivery for the treatment of neurological disorders	37
Molecular disease mechanisms of human antineuronal monoclonal autoantibodies	36
The emerging Janus face of SVEP1 in development and disease	35
Targeting mitochondrial transfer as a promising therapeutic strategy	34
Maternal obesity: new placental paradigms unfolded	34

IL-15 in CAR engineering: striking an efficacy–safety balance	34
CaMKK2: A tumor stress-integration node	34
Advisory Board and Contents	33
Science around the world	33
Leveraging zebrafish to investigate pancreatic development, regeneration, and diabetes	32
Unraveling host genetics and microbiome genome crosstalk: a novel therapeutic approach	31
Advisory Board and Contents	31
Translational opportunities emerge from genetic influences on health	31
Cystic fibrosis at a glance: from disease mechanism to therapy	30
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Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery	30
Advisory Board and Contents	30
Molecular basis and clinical implications of TANGO2 deficiency disorder	29
The overlooked uterine factor: unlocking endometrium potential in premature ovarian insufficiency	29
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health	29
HIF2 drives PTHrP-mediated cancer cachexia	29
Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer	29
Incorporating placental pathology into clinical care and research	28
ABC transporters: human disease and pharmacotherapeutic potential	28
The global human gut microbiome: genes, lifestyles, and diet	28
Endosomal signaling disorders: a new category for immune dysregulation	28
Autoantibodies as drivers of neuropathic pain	27
Gasdermins in pyroptosis, inflammation, and cancer	27
Fibroblasts in AKI: small army, big help	27
Lipedema: a chronic adipose tissue disease	27
Biodiversity: the overlooked source of human health	27
Advisory Board and Contents	26
iPSC-derived models for anorexia nervosa research	26
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes	26
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From pixels to patients: the evolution and future of deep learning in cancer diagnostics	26
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BH3 mimetic therapies for CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia	26
Advisory Board and Contents	26
Dissecting mechanisms of fecal microbiota transplantation efficacy in disease	25
Novel universal vaccines to mitigate emerging avian influenza viruses	25
Molecular basis and clinical implications of HIFs in cardiovascular diseases	25
Human dopaminergic system in the exercise-cognition link	25
TIM-3 blockade: immune and targeted therapy in DIPG	24
Vaccine-based immunotherapy and related preclinical models for glioma	24
Advisory Board and Contents	24
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Autoimmune diseases and cardiovascular risk	23
Keratin 16 puts the brakes on type I interferon signalling	23
Asthma exacerbations: the Achilles heel of asthma care	23
Vitiligo: advances in pathophysiology research and treatment development	23
Renin–angiotensin system: a novel target for brain health	23
Glycosylation of blood cells during the onset and progression of atherosclerosis and myocardial infarction	22
Deciphering the MYCN-driven metabolic microenvironment of neuroblastoma	22
Epigenetic remodeling after viral pneumonia accelerates lung tumorigenesis	22
Foxp3+ Tregs in HCC immunity and immunotherapy	22
mRNA vaccine platforms to prevent bacterial infections	22
Advisory Board and Contents	21
Tumor microenvironment and metabolic reprogramming in MASLD-related hepatocellular carcinoma	21
Organ-specific aging in the plasma proteome predicts disease	21
Staging of Alzheimer’s disease: past, present, and future perspectives	21
Thirty years of molecular medicine: reflections from an academic physician-scientist, 1995–2025	21
HPV integration and cervical cancer: a failed evolutionary viral trait	21
There is nothing as inconsistent as the OSFED diagnostic criteria	20
Amyotrophic lateral sclerosis: A rare but aggressive adult-onset disease	20
Missing links in preeclampsia cell model systems of endothelial dysfunction	20
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases	20
Redefining metalloproteases specificity through network proteolysis	20
Treating Niemann-Pick C lysosomal storage: approved and emerging approaches	20
Why we must fight ignorance about COVID-19 vaccines and menstrual cycles	20
Repurposing of microbial proteins as new-generation therapeutic agents for biomedical applications	20
Telomere biology disorders: time for moving towards the clinic?	20
Primary cilia shape hallmarks of health and aging	19
Engaging the ZBP1 axis: from nucleic acid stress to antitumor immunity	19
Copy number alterations: a catastrophic orchestration of the breast cancer genome	19
Common mechanisms in pediatric acute liver failure	19
The future of phage therapy in the USA	19
The dual role of the TSC complex in cancer	19
Predicting healthspan and disease risks through biological age	19
Tertiary lymphoid structures in the central nervous system	19
Advisory Board and Contents	18
Dysfunctional tRNA reprogramming and codon-biased translation in cancer	18
Treatment and research needs for severe eating disorders: a response to Dr Ayton	18
Rejuvenating the human gut microbiome	18
Precision medicine targeting ferroptosis in cerebrovascular diseases	18

Dynamic rewiring of neurovasculature in health and disease	17
Safety of non-replicative and oncolytic replication-selective HSV vectors	17
Clinical crusade: zosurabalpin's charge against antibiotic resistance	17
The aging lipidome: exercise is medicine	17
Advisory Board and Contents	17
Adenoviruses in medicine: innocuous pathogen, predator, or partner	17
Multiomics tools for improved atherosclerotic cardiovascular disease management	17
Nanocarrier vaccines for respiratory infections	17
IL-6: a pivotal molecule for tumor–brain dysfunction interaction	17
Cancer driver mutations: predictions and reality	17
Advisory Board and Contents	17
Short-chain fatty acids in fetal development and metabolism	16
Digital health applications for eating disorders treatment	16
Advisory Board and Contents	16
Brain-related sexual dimorphism in tuberous sclerosis complex: an overlooked matter	16
Nontraditional models as research tools: the road not taken	16
Bearing allostatic load: insights into a more equitable future within cardio-oncology	16
Are GLP-1R agonists the long-sought-after panacea for obesity?	16
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Advances in Hodgkin lymphoma research	16
Targeting the hyaluronic acid–CD44 axis in hepatocellular carcinoma	16
Targeting endoplasmic reticulum stress and nitroso–redox imbalance in cancer progression	16
Targeting the NAD+–PARP1–XRCC1 axis in ALS	15
Block, expose, and immunize: triple attack on cancer	15
Advisory Board and Contents	15
Interdisciplinary approaches for the discovery of novel antifungals	15
Science around the world	15
Epigenetic regulation of tumor-immune symbiosis in glioma	15
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Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements	14
Pig models for translational Duchenne muscular dystrophy research	14
Nanobodies as a powerful platform for biomedicine	14
Understanding preeclampsia: from phenotypes to treatment	14
Novel bladder-sparing approaches in patients with muscle-invasive bladder cancer	14
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Updates and advances in pyruvate kinase deficiency	13
Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases	13
Targeting pathological ERK1/2 signaling in cancer and beyond	13
Clonal hematopoiesis of indeterminate potential: the root cause of, and fertile ground for, hematological malignancies	13
Gene therapy for β-thalassemia: current and future options	13
Advisory Board and Contents	12
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Patients as biomedical researchers	12
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ILC2s in cancer: good, bad, or stay tuned?	12
Advisory Board and Contents	12
Correction to: siRNA modification and delivery for drug development	12
Metabolic symphony coordinates the muscle regeneration niche	12
Advisory Board and Contents	11
Physical activity, cathepsin B, and cognitive health	11
Development of asparagine endopeptidase inhibitors for treating neurodegenerative diseases	11
Antibody class-switching as a strategy to improve HIV-1 neutralization	11
Erythroid–hormonal axis in long COVID	11
From pathophysiology to treatment in transthyretin cardiac amyloidosis	11
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Barrier organ mechanomedicine and therapeutic insights	11
Can’t handle the stress? Mechanobiology and disease	11
Cholesterol efflux in HIV-associated atherosclerosis: mechanisms and targets	11
Patient-specific liver assembloids for disease modeling	10
SARS-CoV-2 targets the liver and manipulates glucose metabolism	10
The body is not just impacted by eating disorders – biology drives them	10
Genetic causes of obesity: mapping a path forward	10
Pulmonary fibrosis: from pathogenesis to clinical decision-making	10
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Psoriatic arthritis: diagnosis, pathogenesis, and emerging therapies	10
Science around the world	10
Cell-free and extrachromosomal DNA profiling of small cell lung cancer	10
Advancements and challenges in mouse models of Alzheimer’s disease	10
Recent insights into lysosomal acid lipase deficiency	10
Advisory Board and Contents	10
Post-acute anti-NMDAR encephalitis mirrors schizophrenia	10
Erythrophagocytes in hemolytic anemia, wound healing, and cancer	10
Exploiting pancreatic cancer metabolism: challenges and opportunities	10
Next-generation immune profiling – beyond blood cancer cells	10
Narcolepsy type 1: an autoimmune disease	9
Imaging genomics: data fusion in uncovering disease heritability	9
Powering immunity: mitochondrial dynamics in natural killer cells	9
Polycystic kidney disease: novel insights into polycystin function	9
Molecular therapy for polyQ disorders: from bench to clinical trials	9
A sex-biased target against demyelination in Alzheimer’s disease	9
Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies	9
Microbiome-targeted interventions for the control of oral–gut dysbiosis and chronic systemic inflammation	9
RyR-mediated calcium release in hippocampal health and disease	9
Burden of hereditary enamel disorders	9
Patient-specific trophoblast stem cells for placental medicine	9
Technologies for chimeric antigen receptor transgene delivery	9
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Tryptophan metabolites at the service of neuroimmune sensing of microbes	8
Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications	8
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Neurotransmitter-activated GPCR signaling in myelin plasticity	8
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Host–microbe interactions in NAD+ metabolism	8
Science around the world	8