Trends in Molecular Medicine

Article	Citations
Advisory Board and Contents	241
Advisory Board and Contents	232
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Subscription and Copyright Information	211
Advisory Board and Contents	203
The right drug at the right time: key to IBD success	160
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m6A and beyond: RNA modifications shaping angiogenesis	128
Cellular senescence in neuroinflammatory disease: new therapies for old cells?	125
Beneath the radar: immune-evasive cell sources for stroke therapy	113
Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes	105
Muscle-to-CNS signaling in physiological homeostasis, aging, and disease	101
Lymph node microenvironment rewires ferroptosis redox defenses	99
Microbiota: a dawn for cancer metastasis therapy	98
Bursts of brain erosion: seizures and age-dependent neurological vulnerability	94
Consideration of the importance of measuring thermal discomfort in biomedical research	93
d-Amino acids: new clinical pathways for brain diseases	90
Opportunities and challenges for biomarker discovery using electronic health record data	89
Fc-optimized checkpoint antibodies for cancer immunotherapy	87
Neutrophils and extracellular traps in crystal-associated diseases	85
Pushing the boundaries of brain organoids to study Alzheimer’s disease	78
Microbes and mood: innovative biomarker approaches in depression	77
Advancements in intensive eating disorder treatments: the benefit of CBT-E and integrated care models	77
Hormesis as an adaptive response to infection	76

Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality	74
Advisory Board and Contents	69
Systemically administered alcadein peptide p3-Alcβ neutralizes brain Alzheimer’s Aβ oligomers	68
Brain-specific regulatory T cell expansion limits cognitive decline	68
Engineering cytokines for tumor-targeting and selective T cell activation	67
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients	64
Erythropoietic protoporphyrias: updates and advances	63
Epigenetic regulation in intervertebral disc degeneration	62
Molecular mechanisms in the pathogenesis of dengue infections	61
RNA immunotherapy: revolutionizing cancer and autoimmune disease treatments	59
Is endometriosis a progressive disease?	55
Amyloid and collagen templates in aortic valve calcification	54
Insights from HIV-1 vaccine and passive immunization efficacy trials	54
Emerging roles of cyclin-dependent kinase 7 in health and diseases	54
Keratinocytes: new perspectives in inflammatory skin diseases	53
Acquired resistance to immunotherapy in solid tumors	53
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Three ‘E’ challenges for siRNA drug development	53
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Advisory Board and Contents	52
Roadmap for developing biologically inspired therapeutics for genetic brain disorders	52
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Shining a light on comorbidities	51
Tick-borne encephalitis: emerging clinical trends and challenges	48
Significant challenges to translating breakthrough science in Mexico	48
SOX17: escape route from immune destruction in early CRC	48
Pathogenic mechanisms in genetically defined Ehlers–Danlos syndromes	47
The endoplasmic reticulum proteostasis network and bone disease	46
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation	45
Promoting proteostasis by cAMP/PKA and cGMP/PKG	44
Leptin and male fertility: unraveling the molecular pathways, receptor functions, and therapeutic potential	44
Mitigating age-related somatic mutation burden	43
Antibody signatures in inflammatory bowel disease: current developments and future applications	43
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart	41
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Saving eyesight, one gene at a time	40
The bleeding edge: broadening horizons for hematopoietic stem cell therapies	40
Science around the world	40
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	39
Translation of gene therapy strategies for amyotrophic lateral sclerosis	38
Maternal obesity: new placental paradigms unfolded	38
Two-pronged immune evasion of pseudouridine-modified RNA	37
Focused ultrasound gene delivery for the treatment of neurological disorders	36
Naked mole-rats: at the heart of it	36
IL-15 in CAR engineering: striking an efficacy–safety balance	36
Targeting mitochondrial transfer as a promising therapeutic strategy	35
Molecular disease mechanisms of human antineuronal monoclonal autoantibodies	34
Timing matters: maternal milk IgG sets weaning threshold	34
Decoding atopic dermatitis: pathophysiology, clinical diagnosis, and treatments	34
The emerging Janus face of SVEP1 in development and disease	33

Time-restricted feeding and Alzheimer’s disease: you are when you eat	33
Unraveling host genetics and microbiome genome crosstalk: a novel therapeutic approach	32
Advisory Board and Contents	32
Science around the world	32
HIF2 drives PTHrP-mediated cancer cachexia	31
Fibroblasts in AKI: small army, big help	31
Lipedema: a chronic adipose tissue disease	31
Translational opportunities emerge from genetic influences on health	30
Advisory Board and Contents	30
Autoantibodies as drivers of neuropathic pain	28
The overlooked uterine factor: unlocking endometrium potential in premature ovarian insufficiency	28
Advisory Board and Contents	28
Cystic fibrosis at a glance: from disease mechanism to therapy	28
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Molecular basis and clinical implications of TANGO2 deficiency disorder	28
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health	27
Gasdermins in pyroptosis, inflammation, and cancer	27
Incorporating placental pathology into clinical care and research	27
ABC transporters: human disease and pharmacotherapeutic potential	27
Leveraging zebrafish to investigate pancreatic development, regeneration, and diabetes	27
Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer	27
Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery	27
The global human gut microbiome: genes, lifestyles, and diet	26
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes	26
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Biodiversity: the overlooked source of human health	25
Advisory Board and Contents	25
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Dissecting mechanisms of fecal microbiota transplantation efficacy in disease	24
BH3 mimetic therapies for CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia	24
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	24
Novel universal vaccines to mitigate emerging avian influenza viruses	24
Advisory Board and Contents	24
Human dopaminergic system in the exercise-cognition link	24
iPSC-derived models for anorexia nervosa research	24
TIM-3 blockade: immune and targeted therapy in DIPG	23
Vaccine-based immunotherapy and related preclinical models for glioma	23
Circadian molecular clock disruption in chronic pulmonary diseases	23
Autoimmune diseases and cardiovascular risk	23
Advisory Board and Contents	23
Molecular basis and clinical implications of HIFs in cardiovascular diseases	23
Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias	23
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Vitiligo: advances in pathophysiology research and treatment development	22
Epigenetic remodeling after viral pneumonia accelerates lung tumorigenesis	21
Glycosylation of blood cells during the onset and progression of atherosclerosis and myocardial infarction	21
Tumor microenvironment and metabolic reprogramming in MASLD-related hepatocellular carcinoma	21
Renin–angiotensin system: a novel target for brain health	21
Deciphering the MYCN-driven metabolic microenvironment of neuroblastoma	21
Asthma exacerbations: the Achilles heel of asthma care	21
Advisory Board and Contents	20
mRNA vaccine platforms to prevent bacterial infections	20
The future of phage therapy in the USA	20
HPV integration and cervical cancer: a failed evolutionary viral trait	20
Organ-specific aging in the plasma proteome predicts disease	20
Staging of Alzheimer’s disease: past, present, and future perspectives	20
Predicting healthspan and disease risks through biological age	19
Common mechanisms in pediatric acute liver failure	19
The dual role of the TSC complex in cancer	19
Repurposing of microbial proteins as new-generation therapeutic agents for biomedical applications	19
Thirty years of molecular medicine: reflections from an academic physician-scientist, 1995–2025	19
Treating Niemann-Pick C lysosomal storage: approved and emerging approaches	19
Redefining metalloproteases specificity through network proteolysis	19
Why we must fight ignorance about COVID-19 vaccines and menstrual cycles	19
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases	19
Missing links in preeclampsia cell model systems of endothelial dysfunction	19
Copy number alterations: a catastrophic orchestration of the breast cancer genome	18
There is nothing as inconsistent as the OSFED diagnostic criteria	18
Telomere biology disorders: time for moving towards the clinic?	18
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections	18
Tertiary lymphoid structures in the central nervous system	18
Primary cilia shape hallmarks of health and aging	18
Dysfunctional tRNA reprogramming and codon-biased translation in cancer	18
IL-6: a pivotal molecule for tumor–brain dysfunction interaction	17
Treatment and research needs for severe eating disorders: a response to Dr Ayton	17
Clinical crusade: zosurabalpin's charge against antibiotic resistance	17
Rejuvenating the human gut microbiome	17
The aging lipidome: exercise is medicine	17
Advisory Board and Contents	17
Nanocarrier vaccines for respiratory infections	17

Advisory Board and Contents	17
Dynamic rewiring of neurovasculature in health and disease	17
Multiomics tools for improved atherosclerotic cardiovascular disease management	17
Adenoviruses in medicine: innocuous pathogen, predator, or partner	16
Targeting endoplasmic reticulum stress and nitroso–redox imbalance in cancer progression	16
Digital health applications for eating disorders treatment	16
Nontraditional models as research tools: the road not taken	16
Cancer driver mutations: predictions and reality	16
Advances in Hodgkin lymphoma research	16
Advisory Board and Contents	16
Targeting the hyaluronic acid–CD44 axis in hepatocellular carcinoma	16
Brain-related sexual dimorphism in tuberous sclerosis complex: an overlooked matter	16
Safety of non-replicative and oncolytic replication-selective HSV vectors	16
Bearing allostatic load: insights into a more equitable future within cardio-oncology	16
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Short-chain fatty acids in fetal development and metabolism	16
Are GLP-1R agonists the long-sought-after panacea for obesity?	16
Science around the world	15
Clonal hematopoiesis of indeterminate potential: the root cause of, and fertile ground for, hematological malignancies	15
Updates and advances in pyruvate kinase deficiency	15
Targeting the NAD+–PARP1–XRCC1 axis in ALS	15
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Interdisciplinary approaches for the discovery of novel antifungals	15
Targeting pathological ERK1/2 signaling in cancer and beyond	15
Advisory Board and Contents	15
Gene therapy for β-thalassemia: current and future options	15
Novel bladder-sparing approaches in patients with muscle-invasive bladder cancer	14
Understanding preeclampsia: from phenotypes to treatment	14
Pig models for translational Duchenne muscular dystrophy research	14
Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements	14
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Epigenetic regulation of tumor-immune symbiosis in glioma	13
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Block, expose, and immunize: triple attack on cancer	13
Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases	13
Nanobodies as a powerful platform for biomedicine	13
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Development of asparagine endopeptidase inhibitors for treating neurodegenerative diseases	12
Correction to: siRNA modification and delivery for drug development	12
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Antibody class-switching as a strategy to improve HIV-1 neutralization	12
Advisory Board and Contents	12
From pathophysiology to treatment in transthyretin cardiac amyloidosis	12
Patients as biomedical researchers	12
Nutrition interventions in congenital disorders of glycosylation	12
Advisory Board and Contents	12
Physical activity, cathepsin B, and cognitive health	12
ILC2s in cancer: good, bad, or stay tuned?	12
Cholesterol efflux in HIV-associated atherosclerosis: mechanisms and targets	11
Advancements and challenges in mouse models of Alzheimer’s disease	11
Advisory Board and Contents	11
Barrier organ mechanomedicine and therapeutic insights	11
Erythrophagocytes in hemolytic anemia, wound healing, and cancer	11
Metabolic symphony coordinates the muscle regeneration niche	11
Erythroid–hormonal axis in long COVID	11
The body is not just impacted by eating disorders – biology drives them	11
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Exploiting pancreatic cancer metabolism: challenges and opportunities	10
Exposing the role of metals in neurological disorders: a focus on manganese	10
Science around the world	10
Next-generation immune profiling – beyond blood cancer cells	10
Cell-free and extrachromosomal DNA profiling of small cell lung cancer	10
Can’t handle the stress? Mechanobiology and disease	10
Recent insights into lysosomal acid lipase deficiency	10
Genetic causes of obesity: mapping a path forward	10
Pulmonary fibrosis: from pathogenesis to clinical decision-making	10
Psoriatic arthritis: diagnosis, pathogenesis, and emerging therapies	9
Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies	9
A sex-biased target against demyelination in Alzheimer’s disease	9
Advisory Board and Contents	9
Microbiome-targeted interventions for the control of oral–gut dysbiosis and chronic systemic inflammation	9
Advisory Board and Contents	9
Patient-specific liver assembloids for disease modeling	9
Polycystic kidney disease: novel insights into polycystin function	9
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Subscription and Copyright Information	9
Molecular therapy for polyQ disorders: from bench to clinical trials	8
SARS-CoV-2 targets the liver and manipulates glucose metabolism	8
Imaging genomics: data fusion in uncovering disease heritability	8
Narcolepsy type 1: an autoimmune disease	8
RyR-mediated calcium release in hippocampal health and disease	8
Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications	8
Powering immunity: mitochondrial dynamics in natural killer cells	8
Post-acute anti-NMDAR encephalitis mirrors schizophrenia	8
Suicide prevention in cancer: earlier is better	8
Patient-specific trophoblast stem cells for placental medicine	8
Circadian phase instability in bipolar disorder: a neglected essence	7
COVID-19 vaccines in pregnancy	7
The inaccessible road to science for people with disabilities	7
New strategies for the treatment of chronic hepatitis B	7
Molecular links between allergy and cancer	7
β2ARs: double edge sword in heart function	7
Could venom-derived therapeutics resolve treatment resistance in refractory EAC?	7
Cancer quiescence: non-coding RNAs in the spotlight	7
Endometriosis and comorbidities: molecular mechanisms and clinical implications	7