Trends in Molecular Medicine

Article	Citations
Advisory Board and Contents	231
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Advisory Board and Contents	223
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Advisory Board and Contents	196
The right drug at the right time: key to IBD success	150
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Subscription and Copyright Information	128
m6A and beyond: RNA modifications shaping angiogenesis	126
Cellular senescence in neuroinflammatory disease: new therapies for old cells?	122
Pushing the boundaries of brain organoids to study Alzheimer’s disease	117
Beneath the radar: immune-evasive cell sources for stroke therapy	111
Bursts of brain erosion: seizures and age-dependent neurological vulnerability	100
Opportunities and challenges for biomarker discovery using electronic health record data	100
Consideration of the importance of measuring thermal discomfort in biomedical research	96
Lymph node microenvironment rewires ferroptosis redox defenses	95
Microbiota: a dawn for cancer metastasis therapy	92
Muscle-to-CNS signaling in physiological homeostasis, aging, and disease	91
Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes	88
Fc-optimized checkpoint antibodies for cancer immunotherapy	86
d-Amino acids: new clinical pathways for brain diseases	85
Neutrophils and extracellular traps in crystal-associated diseases	81
Advancements in intensive eating disorder treatments: the benefit of CBT-E and integrated care models	78
Amyloid and collagen templates in aortic valve calcification	75
Engineering cytokines for tumor-targeting and selective T cell activation	73

Insights from HIV-1 vaccine and passive immunization efficacy trials	72
Molecular mechanisms in the pathogenesis of dengue infections	71
Advisory Board and Contents	67
Emerging roles of cyclin-dependent kinase 7 in health and diseases	67
Subscription and Copyright Information	65
Brain-specific regulatory T cell expansion limits cognitive decline	65
Systemically administered alcadein peptide p3-Alcβ neutralizes brain Alzheimer’s Aβ oligomers	62
Erythropoietic protoporphyrias: updates and advances	62
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients	61
Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality	60
Acquired resistance to immunotherapy in solid tumors	56
Hormesis as an adaptive response to infection	54
Microbes and mood: innovative biomarker approaches in depression	54
Is endometriosis a progressive disease?	53
SOX17: escape route from immune destruction in early CRC	52
Keratinocytes: new perspectives in inflammatory skin diseases	52
Epigenetic regulation in intervertebral disc degeneration	52
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RNA immunotherapy: revolutionizing cancer and autoimmune disease treatments	52
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart	52
Three ‘E’ challenges for siRNA drug development	52
Shining a light on comorbidities	50
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Advisory Board and Contents	48
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Roadmap for developing biologically inspired therapeutics for genetic brain disorders	47
Advisory Board and Contents	47
Antibody signatures in inflammatory bowel disease: current developments and future applications	46
Leptin and male fertility: unraveling the molecular pathways, receptor functions, and therapeutic potential	44
Promoting proteostasis by cAMP/PKA and cGMP/PKG	44
Pathogenic mechanisms in genetically defined Ehlers–Danlos syndromes	43
Significant challenges to translating breakthrough science in Mexico	42
Tick-borne encephalitis: emerging clinical trends and challenges	42
The endoplasmic reticulum proteostasis network and bone disease	42
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation	41
Mitigating age-related somatic mutation burden	41
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Time-restricted feeding and Alzheimer’s disease: you are when you eat	39
Science around the world	39
Timing matters: maternal milk IgG sets weaning threshold	38
The bleeding edge: broadening horizons for hematopoietic stem cell therapies	38
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	37
Saving eyesight, one gene at a time	37
Translation of gene therapy strategies for amyotrophic lateral sclerosis	36
Decoding atopic dermatitis: pathophysiology, clinical diagnosis, and treatments	35
Targeting mitochondrial transfer as a promising therapeutic strategy	35
Focused ultrasound gene delivery for the treatment of neurological disorders	34
Maternal obesity: new placental paradigms unfolded	34
IL-15 in CAR engineering: striking an efficacy–safety balance	33
Two-pronged immune evasion of pseudouridine-modified RNA	33

The emerging Janus face of SVEP1 in development and disease	32
Naked mole-rats: at the heart of it	32
Advisory Board and Contents	31
Molecular disease mechanisms of human antineuronal monoclonal autoantibodies	31
Science around the world	31
Unraveling host genetics and microbiome genome crosstalk: a novel therapeutic approach	30
Fibroblasts in AKI: small army, big help	30
Incorporating placental pathology into clinical care and research	30
Biodiversity: the overlooked source of human health	29
Leveraging zebrafish to investigate pancreatic development, regeneration, and diabetes	27
HIF2 drives PTHrP-mediated cancer cachexia	27
Advisory Board and Contents	27
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health	27
Translational opportunities emerge from genetic influences on health	27
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Advisory Board and Contents	26
Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery	26
Autoantibodies as drivers of neuropathic pain	26
The overlooked uterine factor: unlocking endometrium potential in premature ovarian insufficiency	26
Lipedema: a chronic adipose tissue disease	26
ABC transporters: human disease and pharmacotherapeutic potential	26
Gasdermins in pyroptosis, inflammation, and cancer	25
Cystic fibrosis at a glance: from disease mechanism to therapy	25
Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer	25
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BH3 mimetic therapies for CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia	24
Molecular basis and clinical implications of HIFs in cardiovascular diseases	24
The global human gut microbiome: genes, lifestyles, and diet	24
Advisory Board and Contents	24
iPSC-derived models for anorexia nervosa research	24
Advisory Board and Contents	24
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes	24
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Novel universal vaccines to mitigate emerging avian influenza viruses	24
Renin–angiotensin system: a novel target for brain health	23
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	23
Stratum corneum as polymer sheet: concept and cornification processes	23
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Human dopaminergic system in the exercise-cognition link	23
TIM-3 blockade: immune and targeted therapy in DIPG	23
Circadian molecular clock disruption in chronic pulmonary diseases	23
Dissecting mechanisms of fecal microbiota transplantation efficacy in disease	23
Staging of Alzheimer’s disease: past, present, and future perspectives	22
Asthma exacerbations: the Achilles heel of asthma care	22
Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias	22
Vaccine-based immunotherapy and related preclinical models for glioma	22
Advisory Board and Contents	22
Autoimmune diseases and cardiovascular risk	22
Vitiligo: advances in pathophysiology research and treatment development	21
Deciphering the MYCN-driven metabolic microenvironment of neuroblastoma	20
Epigenetic remodeling after viral pneumonia accelerates lung tumorigenesis	20
Glycosylation of blood cells during the onset and progression of atherosclerosis and myocardial infarction	20
mRNA vaccine platforms to prevent bacterial infections	20
Advisory Board and Contents	19
Common mechanisms in pediatric acute liver failure	19
The dual role of the TSC complex in cancer	19
Organ-specific aging in the plasma proteome predicts disease	19
Redefining metalloproteases specificity through network proteolysis	19
HPV integration and cervical cancer: a failed evolutionary viral trait	19
The future of phage therapy in the USA	19
Primary cilia shape hallmarks of health and aging	18
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases	18
Treating Niemann-Pick C lysosomal storage: approved and emerging approaches	18
Why we must fight ignorance about COVID-19 vaccines and menstrual cycles	18
Predicting healthspan and disease risks through biological age	18
Thirty years of molecular medicine: reflections from an academic physician-scientist, 1995–2025	18
Missing links in preeclampsia cell model systems of endothelial dysfunction	18
Dysfunctional tRNA reprogramming and codon-biased translation in cancer	18
Copy number alterations: a catastrophic orchestration of the breast cancer genome	18
There is nothing as inconsistent as the OSFED diagnostic criteria	18
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections	18
Tertiary lymphoid structures in the central nervous system	17
Advisory Board and Contents	17
Telomere biology disorders: time for moving towards the clinic?	17
Treatment and research needs for severe eating disorders: a response to Dr Ayton	17
Advisory Board and Contents	17
Repurposing of microbial proteins as new-generation therapeutic agents for biomedical applications	17
IL-6: a pivotal molecule for tumor–brain dysfunction interaction	17
Advisory Board and Contents	16
Multiomics tools for improved atherosclerotic cardiovascular disease management	16

The aging lipidome: exercise is medicine	16
Safety of non-replicative and oncolytic replication-selective HSV vectors	16
Bearing allostatic load: insights into a more equitable future within cardio-oncology	16
Digital health applications for eating disorders treatment	16
Cancer driver mutations: predictions and reality	16
Rejuvenating the human gut microbiome	16
Adenoviruses in medicine: innocuous pathogen, predator, or partner	16
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Targeting endoplasmic reticulum stress and nitroso–redox imbalance in cancer progression	16
Dynamic rewiring of neurovasculature in health and disease	16
Nanocarrier vaccines for respiratory infections	16
Clinical crusade: zosurabalpin's charge against antibiotic resistance	16
Brain-related sexual dimorphism in tuberous sclerosis complex: an overlooked matter	15
Science around the world	15
Clonal hematopoiesis of indeterminate potential: the root cause of, and fertile ground for, hematological malignancies	15
Targeting the hyaluronic acid–CD44 axis in hepatocellular carcinoma	15
Short-chain fatty acids in fetal development and metabolism	15
Advances in Hodgkin lymphoma research	15
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Nontraditional models as research tools: the road not taken	15
Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases	15
Advisory Board and Contents	15
Are GLP-1R agonists the long-sought-after panacea for obesity?	15
Nanobodies as a powerful platform for biomedicine	14
Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements	14
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Pig models for translational Duchenne muscular dystrophy research	14
Novel bladder-sparing approaches in patients with muscle-invasive bladder cancer	14
Understanding preeclampsia: from phenotypes to treatment	14
Block, expose, and immunize: triple attack on cancer	14
Targeting pathological ERK1/2 signaling in cancer and beyond	13
Advisory Board and Contents	13
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Epigenetic regulation of tumor-immune symbiosis in glioma	13
Interdisciplinary approaches for the discovery of novel antifungals	13
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Gene therapy for β-thalassemia: current and future options	13
Updates and advances in pyruvate kinase deficiency	13
Advisory Board and Contents	13
Next-generation immune profiling – beyond blood cancer cells	12
Correction to: siRNA modification and delivery for drug development	12
Advancements and challenges in mouse models of Alzheimer’s disease	12
Erythrophagocytes in hemolytic anemia, wound healing, and cancer	12
Genetic causes of obesity: mapping a path forward	12
Can’t handle the stress? Mechanobiology and disease	11
Exposing the role of metals in neurological disorders: a focus on manganese	11
Patients as biomedical researchers	11
Exploiting pancreatic cancer metabolism: challenges and opportunities	11
Pulmonary fibrosis: from pathogenesis to clinical decision-making	11
Cholesterol efflux in HIV-associated atherosclerosis: mechanisms and targets	11
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Cell-free and extrachromosomal DNA profiling of small cell lung cancer	11
Recent insights into lysosomal acid lipase deficiency	11
From pathophysiology to treatment in transthyretin cardiac amyloidosis	11
Barrier organ mechanomedicine and therapeutic insights	11
Development of asparagine endopeptidase inhibitors for treating neurodegenerative diseases	10
The body is not just impacted by eating disorders – biology drives them	10
A sex-biased target against demyelination in Alzheimer’s disease	10
ILC2s in cancer: good, bad, or stay tuned?	10
Physical activity, cathepsin B, and cognitive health	10
Science around the world	10
Metabolic symphony coordinates the muscle regeneration niche	10
Antibody class-switching as a strategy to improve HIV-1 neutralization	10
Nutrition interventions in congenital disorders of glycosylation	10
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Advisory Board and Contents	9
Powering immunity: mitochondrial dynamics in natural killer cells	9
Patient-specific liver assembloids for disease modeling	9
Molecular therapy for polyQ disorders: from bench to clinical trials	9
Advisory Board and Contents	9
SARS-CoV-2 targets the liver and manipulates glucose metabolism	9
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Polycystic kidney disease: novel insights into polycystin function	9
Post-acute anti-NMDAR encephalitis mirrors schizophrenia	9
Convalescent plasma to deliver therapeutic antibodies against COVID-19	9
Burden of hereditary enamel disorders	9
Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies	9
Psoriatic arthritis: diagnosis, pathogenesis, and emerging therapies	8
Microbiome-targeted interventions for the control of oral–gut dysbiosis and chronic systemic inflammation	8
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Technologies for chimeric antigen receptor transgene delivery	8
Patient-specific trophoblast stem cells for placental medicine	8
Imaging genomics: data fusion in uncovering disease heritability	8
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Narcolepsy type 1: an autoimmune disease	8
RyR-mediated calcium release in hippocampal health and disease	8
Suicide prevention in cancer: earlier is better	8
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Rett syndrome: a complex disorder with promising therapeutic prospects	8
Circular RNA translation: novel protein isoforms and clinical significance	8
Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications	8
COVID-19 vaccines in pregnancy	7
Circadian phase instability in bipolar disorder: a neglected essence	7
New insights into gut microbiota–prostate cancer crosstalk	7
Tryptophan metabolites at the service of neuroimmune sensing of microbes	7