Trends in Molecular Medicine

(The median citation count of Trends in Molecular Medicine is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)
COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives393
Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies196
Mitophagy and Neuroprotection196
PRMTs and Arginine Methylation: Cancer’s Best-Kept Secret?170
Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus165
Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response160
G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies154
Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies148
Mitochondria–Lysosome Crosstalk: From Physiology to Neurodegeneration138
Impact of the Natural Compound Urolithin A on Health, Disease, and Aging126
Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease124
Immunomodulatory TGF-β Signaling in Hepatocellular Carcinoma122
Cell-Free DNA and Apoptosis: How Dead Cells Inform About the Living118
Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function113
Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome110
The Gut Microbiota: Emerging Evidence in Autoimmune Diseases107
Regulation of Mitochondrial ATP Production: Ca2+ Signaling and Quality Control103
Ferroptosis in the tumor microenvironment: perspectives for immunotherapy101
The Mitochondrion as an Emerging Therapeutic Target in Cancer99
Reducing Senescent Cell Burden in Aging and Disease85
Cisplatin-Induced Ototoxicity: Updates on Molecular Targets85
Liquid Biopsy of Methylation Biomarkers in Cell-Free DNA84
Microglia as Dynamic Cellular Mediators of Brain Function83
Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer’s Disease80
Cell-to-Cell Transmission of Tau and α-Synuclein79
Crosstalk between Sertoli and Germ Cells in Male Fertility74
Mitochondrial Defects Drive Degenerative Retinal Diseases66
Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis63
Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases63
Drug Development for the Therapy of Mitochondrial Diseases62
Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases?61
Vitamins for the Gut Microbiome60
Metabolic Pathways That Control Skin Homeostasis and Inflammation60
Antibiotic Resistance by Enzymatic Modification of Antibiotic Targets59
Transcription Factor Inhibition: Lessons Learned and Emerging Targets59
Missing Pieces to the Endocannabinoid Puzzle59
NIRF Nanoprobes for Cancer Molecular Imaging: Approaching Clinic58
Extracellular matrix-based cancer targeting54
tRNA Deregulation and Its Consequences in Cancer52
Applications of Spherical Nucleic Acid Nanoparticles as Delivery Systems51
The Vicious Cycle of Arterial Stiffness and Arterial Media Calcification49
NMDARs in Cell Survival and Death: Implications in Stroke Pathogenesis and Treatment48
Enhancers in disease: molecular basis and emerging treatment strategies48
Haptoglobin Therapeutics and Compartmentalization of Cell-Free Hemoglobin Toxicity47
COVID-19 in pregnancy: implications for fetal brain development47
Visualizing Mitochondrial Form and Function within the Cell47
Astrocytes: Emerging Therapeutic Targets in Neurological Disorders47
Ferroptosis in Parkinson’s disease: glia–neuron crosstalk46
Microbiota and sleep: awakening the gut feeling46
Fertility Preservation: The Challenge of Freezing and Transplanting Ovarian Tissue46
An Organ-On-A-Chip Engineered Platform to Study the Microbiota–Gut–Brain Axis in Neurodegeneration46
Activity-Based Diagnostics: An Emerging Paradigm for Disease Detection and Monitoring44
Skin senescence: mechanisms and impact on whole-body aging44
Pregnancy and Breast Cancer: Pathways to Understand Risk and Prevention42
Preimplantation Genetic Testing for Aneuploidy – a Castle Built on Sand42
Deciphering the Ecology of Cystic Fibrosis Bacterial Communities: Towards Systems-Level Integration42
Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective42
Mitochondrial Regulation of Stem Cells in Bone Homeostasis40
Fibroblast Heterogeneity in Wound Healing: Hurdles to Clinical Translation40
Bacterial Peptidoglycan as a Driver of Chronic Brain Inflammation39
The gut vascular barrier: a new player in the gut–liver–brain axis39
Mouth-Watering Results: Clinical Need, Current Approaches, and Future Directions for Salivary Gland Regeneration38
Mitochondria as Therapeutic Targets in Transplantation38
Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia38
HDL and Reverse Remnant-Cholesterol Transport (RRT): Relevance to Cardiovascular Disease38
Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery37
Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines37
Chemical Chaperones as Novel Drugs for Parkinson’s Disease37
Bacterial Peptidoglycans from Microbiota in Neurodevelopment and Behavior36
Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation36
Multitissue Multiomics Systems Biology to Dissect Complex Diseases35
The Ground Zero of Organismal Life and Aging34
Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis34
Checkpoint Inhibition and Infectious Diseases: A Good Thing?33
Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases32
Assessing Toxicity with Human Cell-Based In Vitro Methods32
FABP4: A New Player in Obesity-Associated Breast Cancer30
Homeostatic maintenance of the lymphatic vasculature30
Pro-cathepsin D, Prosaposin, and Progranulin: Lysosomal Networks in Parkinsonism30
Towards Advanced iPSC-based Drug Development for Neurodegenerative Disease30
Applications of CRISPR/Cas9 Technology in the Treatment of Lung Cancer28
Meet Your Stress Management Professionals: The Endocannabinoids28
Modeling Hypertrophic Cardiomyopathy: Mechanistic Insights and Pharmacological Intervention28
Targeting GPCRs Activated by Fatty Acid-Derived Lipids in Type 2 Diabetes28
Strengthening Causal Inference for Complex Disease Using Molecular Quantitative Trait Loci28
Journey to the Center of the Cell: Tracing the Path of AAV Transduction27
Emergence of New Disease: How Can Artificial Intelligence Help?27
The gut microbiome as a biomarker of differential susceptibility to SARS-CoV-227
Polyhydroxyalkanoates and their advances for biomedical applications27
Toward in silico Identification of Tumor Neoantigens in Immunotherapy27
Extinguishing the Embers: Targeting AML Metabolism26
Circular RNA translation: novel protein isoforms and clinical significance26
Direct Lineage Reprogramming for Brain Repair: Breakthroughs and Challenges26
Leveraging Heterogeneity in Systemic Lupus Erythematosus for New Therapies26
PD-L1 regulation revisited: impact on immunotherapeutic strategies25
Extracellular Vesicles and Biomaterial Design: New Therapies for Cardiac Repair25
Therapeutic Modulation of RNA Splicing in Malignant and Non-Malignant Disease25
Wound Repair, Scar Formation, and Cancer: Converging on Activin25
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?25
CRISPR Diagnosis and Therapeutics with Single Base Pair Precision25
Targeted Avenues for Cancer Treatment: The MEK5–ERK5 Signaling Pathway25
Noncoding RNAs versus Protein Biomarkers in Cardiovascular Disease25
The 3D Genome as a Target for Anticancer Therapy24
Staying in Healthy Contact: How Peroxisomes Interact with Other Cell Organelles24
Tooth Repair and Regeneration: Potential of Dental Stem Cells24
Commercialization of Organoids24
Adeno-Associated Virus Vector for Central Nervous System Gene Therapy24
Type 2 Diabetes Mellitus Drugs for Alzheimer’s Disease: Current Evidence and Therapeutic Opportunities24
Clinical Potential of Kisspeptin in Reproductive Health23
Antibody-Mediated Enzyme Therapeutics and Applications in Glycogen Storage Diseases23
The Urgency of Justice in Research: Beyond COVID-1923
Editing Cytoprotective Autophagy in Glioma: An Unfulfilled Potential for Therapy23
JAK–STAT Targeting Offers Novel Therapeutic Opportunities in Sepsis23
Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing22
Endocannabinoid and Prostanoid Crosstalk in Pain22
DNA Methylation-Based Point-of-Care Cancer Detection: Challenges and Possibilities22
Translational Neuroendocrinology of Human Skin: Concepts and Perspectives22
Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging22
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health21
The Centrosome Linker and Its Role in Cancer and Genetic Disorders21
The COVID-19 Pandemic from an Ophthalmologist’s Perspective20
Low Production of Reactive Oxygen Species Drives Systemic Lupus Erythematosus20
It’s in Our Blood: A Glimpse of Personalized Medicine20
Data-Driven Modeling of Pregnancy-Related Complications20
Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation20
Staging of Alzheimer’s disease: past, present, and future perspectives20
Vaccination against Allergy: A Paradigm Shift?20
Glucocorticoid Maturation of Fetal Cardiovascular Function20
Considering the Immune System during Fecal Microbiota Transplantation for Clostridioides difficile Infection19
Breakthroughs and bottlenecks in autophagy research19
First Trial of CRISPR-Edited T cells in Lung Cancer19
Therapeutic and Diagnostic Implications of T Cell Scarring in Celiac Disease and Beyond19
Circadian molecular clock disruption in chronic pulmonary diseases18
Microbe–MUC1 Crosstalk in Cancer-Associated Infections18
Cancer Surgery 2.0: Guidance by Real-Time Molecular Technologies18
T Cells as Guardians of Pain Resolution18
PD-L1 and B7-1 Cis-Interaction: New Mechanisms in Immune Checkpoints and Immunotherapies18
AAV capsid design: A Goldilocks challenge18
Intestinal mucus barrier: a missing piece of the puzzle in food allergy17
Organoid models: assessing lung cell fate decisions and disease responses17
Genetic and Genomic Mechanisms of Primary Aldosteronism17
Treatment and Prevention of Neurocristopathies17
Sirtuins: To Be or Not To Be in Diabetic Cardiomyopathy17
Therapeutic Approaches in Facioscapulohumeral Muscular Dystrophy17
Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging17
Single extracellular vesicle analysis for early cancer detection17
Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology17
Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors17
CRISPR Craze to Transform Cardiac Biology16
TLR2 as a Therapeutic Target in Bacterial Infection16
Challenges and Opportunities for Translation of Therapies to Improve Cognition in Down Syndrome16
Breakthroughs and Bottlenecks in Microbiome Research16
Molecular pathology of rare progeroid diseases16
Influenza A Viruses: Understanding Human Host Determinants16
Historical Perspective of Clinical Nano and Microparticle Formulations for Delivery of Therapeutics16
Topical Microbial Therapeutics against Respiratory Viral Infections16
Shaping Striated Muscles with Ubiquitin Proteasome System in Health and Disease16
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections16
The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis16
Mislocalisation of Activated Receptor Tyrosine Kinases – Challenges for Cancer Therapy16
Can’t handle the stress? Mechanobiology and disease15
Post-Transcriptional Regulation in Skeletal Muscle Development, Repair, and Disease15
Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment15
Organoid technologies for the study of intestinal microbiota–host interactions15
Harnessing Therapeutic IgE Antibodies to Re-educate Macrophages against Cancer15
Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?14
Emerging Targets for Cardiovascular Disease Prevention in Diabetes14
DNA Damage Repair Deficiency and Synthetic Lethality for Cancer Treatment14
Predicting and Overcoming Taxane Chemoresistance14
Cell-free circulating tumor DNA profiling in cancer management14
Blocking Signalopathic Events to Treat Cerebral Cavernous Malformations14
mRNA therapeutics: beyond vaccine applications14
Ectopic Lymphoid Organs and Immune-Mediated Diseases: Molecular Basis for Pharmacological Approaches14
Role and therapeutic implications of protein glycosylation in neuroinflammation14
A map of the altered glioma metabolism13
Redefining Microglial Identity in Health and Disease at Single-Cell Resolution13
Pluripotent Stem Cell-Based Therapeutics for Muscular Dystrophies13
Exposing the role of metals in neurological disorders: a focus on manganese13
Targeting synaptic plasticity in schizophrenia: insights from genomic studies13
Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance13
CGRP Receptor Antagonism in COVID-19: Potential Cardiopulmonary Adverse Effects13
Priming the Proteasome to Protect against Proteotoxicity12
COVID-19 vaccines in pregnancy12
Development of Humanized Ossicles: Bridging the Hematopoietic Gap12
Multivalent Probes in Molecular Imaging: Reality or Future?12
Therapeutic potential of interleukin-2 in autoimmune diseases12
A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes12
Nutrition interventions in congenital disorders of glycosylation11
Clock-modulated checkpoints in time-restricted eating11
Strategies of pluripotent stem cell-based therapy for retinal degeneration: update and challenges11
Mining Helminths for Novel Therapeutics11
Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease11
Linking liver metabolic and vascular disease via bile acid signaling11
Organoids, Where We Stand and Where We Go11
Organotypic Neurovascular Models: Past Results and Future Directions10
Moyamoya disease emerging as an immune-related angiopathy10
Adult Pancreatic Acinar Progenitor-like Populations in Regeneration and Cancer10
In Utero Gene Therapy: Progress and Challenges10
Resilience to Stress and Resilience to Pain: Lessons from Molecular Neurobiology and Genetics9
iPSCs and DRGs: stepping stones to new pain therapies9
Molecular Mechanisms and Treatment Options of Nephropathic Cystinosis9
CircRNA perspective: new strategies for RNA therapy9
Molecular Underpinnings Governing Genetic Complexity of ETS-Fusion-Negative Prostate Cancer9
Role of inflammasomes in HIV-1 infection and treatment9
Advances in Inflammasome Research: Recent Breakthroughs and Future Hurdles9
Self-DNA Sensing Fuels HIV-1-Associated Inflammation9
Maternal obesity: new placental paradigms unfolded8
Cardiac Glycosides as Senolytic Compounds8
Pathogenic associations between oral and gastrointestinal diseases8
β Cell Senescence as a Common Contributor to Type 1 and Type 2 Diabetes8
Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates8
ERα in the Control of Mitochondrial Function and Metabolic Health8
Deciphering the Identity of Renin Cells in Health and Disease8
Cell-based regenerative medicine for renovascular disease7
Secondary failure: immune responses to approved protein therapeutics7
Cellular Models and High-Throughput Screening for Genetic Causality of Intellectual Disability7
AAV-Mediated Gene Therapy for Glycosphingolipid Biosynthesis Deficiencies7
Cellular senescence in neuroinflammatory disease: new therapies for old cells?7
PIK3CA-related overgrowth: silver bullets from the cancer arsenal?7
Leveraging cellular mechano-responsiveness for cancer therapy7
Rejuvenating the human gut microbiome7
The spike hypothesis in vaccine-induced adverse effects: questions and answers7
Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies7
The microbiome, guard or threat to infant health7
Therapeutic Opportunities for Repair GPCRs during Intestinal Mucosal Wound Healing7
PRDM12: New Opportunity in Pain Research7
MCL1 as a Therapeutic Target in Parkinson's Disease?7
Translating osteoarthritis genetics research: challenging times ahead7
Glutamine Skipping the Q into Mitochondria6
The physiology of bilirubin: health and disease equilibrium6
Control of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Cancer6
NK cells in the brain: implications for brain tumor development and therapy6
Ubiquitin-modifying enzymes as regulators of colitis6
Molecular disease mechanisms of human antineuronal monoclonal autoantibodies6
RNA Therapeutics Are Stepping Out of the Maze6
Human autophagy measurement: an underappreciated barrier to translation6
Drug Discovery Inspired from Nuclear Receptor Sensing of Microbial Signals6
Epigenetic priming in neurodevelopmental disorders6
Meeting the needs of patients with ultrarare diseases6
Integrating single-cell genomics pipelines to discover mechanisms of stem cell differentiation6
Immunogenicity of SARS-CoV-2 vaccines in patients with cancer6
New insights into vitamin K biology with relevance to cancer6
Adenoviruses in medicine: innocuous pathogen, predator, or partner6
Mitochondria – A Powerful Therapeutic Target6
Epigenetic regulation in intervertebral disc degeneration6
Hair(y) Matters in Melanoma Biology6
Understanding the tuberculosis granuloma: the matrix revolutions6
Stratum corneum as polymer sheet: concept and cornification processes6
Microglia–T cell conversations in brain cancer progression6
Adolescent PCOS: a postpubertal central obesity syndrome6
Transmission of Polycystic Ovary Syndrome via Epigenetic Inheritance6
Environmental perception and control of gastrointestinal immunity by the enteric nervous system6
Clinical implications of vitamin B12 as redox-active cofactor6
A lncRNA Decoy Predicts Sensitivity to Cisplatin5
Microbiome Metabolite Mimics Accelerate Drug Discovery5
Unleashing cell-penetrating peptide applications for immunotherapy5
Dysfunctional T Cell Mitochondria Lead to Premature Aging5
siRNA modification and delivery for drug development5
Understanding human health through metatranscriptomics5
Antibody signatures in inflammatory bowel disease: current developments and future applications5
Readthrough compounds for nonsense mutations: bridging the translational gap5
Accelerated Approval or Risk Reduction? How Response Biomarkers Advance Therapeutics through Clinical Trials in Cystic Fibrosis5
Joining Forces: Improving Clinical Response to Cellular Immunotherapies with Small-Molecule Inhibitors5
Human Narratives in Science: The Power of Storytelling5
Heart Failure and Adipose Mesenchymal Stem Cells5
Exciting Times in the Field of Nucleic Acid Therapeutics5
Unlocking the potential of agonist antibodies for treating cancer using antibody engineering5
Targeting ACC for NASH resolution5
Cutaneous neuroimmune crosstalk in pruritus5
Erythrophagocytes in hemolytic anemia, wound healing, and cancer5
ABC transporters: human disease and pharmacotherapeutic potential5
Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines5
Modeling glioblastoma complexity with organoids for personalized treatments4
Novel Therapies for Pneumonia-Associated Severe Asthma Phenotypes4
IL-33–ILC2 axis in the female reproductive tract4
Calpains as mechanistic drivers and therapeutic targets for ocular disease4
A call for disability health curricula in medical schools4
Compartmentalization and regulation of GTP in control of cellular phenotypes4
Bridging rapid and sustained antidepressant effects of ketamine4
Transplantation of neural progenitor cells into the human CNS4
Neuronal Reprogramming for Brain Repair: Challenges and Perspectives4
Circadian Angiopoietin-Like-4 as a Novel Therapy in Cardiovascular Disease4
Choroideremia: molecular mechanisms and therapies4
LDL-C augments whereas HDL-C prevents inflammatory innate immune memory4
InFUSing antisense oligonucleotides for treating ALS4
Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias4
Molecular basis and clinical implications of HIFs in cardiovascular diseases4
Special delivery! CAR-T cells transport RN7SL1 to the tumor microenvironment4
Nasal vaccines: solutions for respiratory infectious diseases4
Developing Novel Tests to Screen for Fetal Growth Restriction4
Combinatorial therapies for rescuing myotonic dystrophy type 1 skeletal muscle defects4
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart4
A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies4