Trends in Molecular Medicine

Article	Citations
Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies	323
Impact of the Natural Compound Urolithin A on Health, Disease, and Aging	209
Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease	208
Ferroptosis in the tumor microenvironment: perspectives for immunotherapy	171
Liquid Biopsy of Methylation Biomarkers in Cell-Free DNA	163
Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome	159
Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis	133
Ferroptosis in Parkinson’s disease: glia–neuron crosstalk	124
Skin senescence: mechanisms and impact on whole-body aging	112
Metabolic Pathways That Control Skin Homeostasis and Inflammation	108
Enhancers in disease: molecular basis and emerging treatment strategies	107
Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases	93
COVID-19 in pregnancy: implications for fetal brain development	85
The gut vascular barrier: a new player in the gut–liver–brain axis	83
Microbiota and sleep: awakening the gut feeling	79
Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment	77
Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation	77
Extracellular matrix-based cancer targeting	76
Fertility Preservation: The Challenge of Freezing and Transplanting Ovarian Tissue	72
Circular RNA translation: novel protein isoforms and clinical significance	63
Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines	63
Preimplantation Genetic Testing for Aneuploidy – a Castle Built on Sand	61
Fibroblast Heterogeneity in Wound Healing: Hurdles to Clinical Translation	61
HDL and Reverse Remnant-Cholesterol Transport (RRT): Relevance to Cardiovascular Disease	58
Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery	55

Tooth Repair and Regeneration: Potential of Dental Stem Cells	54
FSP1: a key regulator of ferroptosis	54
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health	53
The Ground Zero of Organismal Life and Aging	52
Mitochondria as Therapeutic Targets in Transplantation	52
Polyhydroxyalkanoates and their advances for biomedical applications	52
Journey to the Center of the Cell: Tracing the Path of AAV Transduction	51
Towards Advanced iPSC-based Drug Development for Neurodegenerative Disease	47
Staging of Alzheimer’s disease: past, present, and future perspectives	46
Homeostatic maintenance of the lymphatic vasculature	46
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?	46
The physiology of bilirubin: health and disease equilibrium	45
Leveraging Heterogeneity in Systemic Lupus Erythematosus for New Therapies	44
Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia	44
Single extracellular vesicle analysis for early cancer detection	43
IBD disease-modifying therapies: insights from emerging therapeutics	42
Therapeutic Modulation of RNA Splicing in Malignant and Non-Malignant Disease	41
Adeno-Associated Virus Vector for Central Nervous System Gene Therapy	39
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections	39
Intestinal mucus barrier: a missing piece of the puzzle in food allergy	39
Translational Neuroendocrinology of Human Skin: Concepts and Perspectives	39
Cancer driver mutations: predictions and reality	39
Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases	38
JAK–STAT Targeting Offers Novel Therapeutic Opportunities in Sepsis	38
Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing	37
N6-methyladenosine-mediated gene regulation and therapeutic implications	36
Wound Repair, Scar Formation, and Cancer: Converging on Activin	35
Moyamoya disease emerging as an immune-related angiopathy	35
PD-L1 regulation revisited: impact on immunotherapeutic strategies	35
Organoid models: assessing lung cell fate decisions and disease responses	34
Adolescent PCOS: a postpubertal central obesity syndrome	34
The gut microbiome as a biomarker of differential susceptibility to SARS-CoV-2	34
The Urgency of Justice in Research: Beyond COVID-19	34
Extracellular Vesicles and Biomaterial Design: New Therapies for Cardiac Repair	33
Extinguishing the Embers: Targeting AML Metabolism	32
Can’t handle the stress? Mechanobiology and disease	32
Understanding human health through metatranscriptomics	32
Cancer Surgery 2.0: Guidance by Real-Time Molecular Technologies	32
AAV capsid design: A Goldilocks challenge	32
Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors	31
Therapeutic potential of interleukin-2 in autoimmune diseases	31
Data-Driven Modeling of Pregnancy-Related Complications	31
Circadian molecular clock disruption in chronic pulmonary diseases	31
Molecular pathology of rare progeroid diseases	30
Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation	30
Clinical Potential of Kisspeptin in Reproductive Health	29
Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging	29
Dysfunctional tRNA reprogramming and codon-biased translation in cancer	28
Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?	28
New insights into vitamin K biology with relevance to cancer	28

ABC transporters: human disease and pharmacotherapeutic potential	27
Strategies of pluripotent stem cell-based therapy for retinal degeneration: update and challenges	27
The global human gut microbiome: genes, lifestyles, and diet	27
Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology	27
PD-L1 and B7-1 Cis-Interaction: New Mechanisms in Immune Checkpoints and Immunotherapies	26
Sirtuins: To Be or Not To Be in Diabetic Cardiomyopathy	26
Influenza A Viruses: Understanding Human Host Determinants	25
T Cells as Guardians of Pain Resolution	25
It’s in Our Blood: A Glimpse of Personalized Medicine	25
Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines	24
Readthrough compounds for nonsense mutations: bridging the translational gap	24
Organoid technologies for the study of intestinal microbiota–host interactions	24
Therapeutic Approaches in Facioscapulohumeral Muscular Dystrophy	24
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes	24
Role and therapeutic implications of protein glycosylation in neuroinflammation	24
Pulmonary fibrosis: from pathogenesis to clinical decision-making	24
Treatment and Prevention of Neurocristopathies	24
Adenoviruses in medicine: innocuous pathogen, predator, or partner	23
Exposing the role of metals in neurological disorders: a focus on manganese	23
Breakthroughs and Bottlenecks in Microbiome Research	23
Targeting synaptic plasticity in schizophrenia: insights from genomic studies	23
Linking liver metabolic and vascular disease via bile acid signaling	22
Post-Transcriptional Regulation in Skeletal Muscle Development, Repair, and Disease	22
Redefining Microglial Identity in Health and Disease at Single-Cell Resolution	22
Multivalent Probes in Molecular Imaging: Reality or Future?	22
Pathogenic associations between oral and gastrointestinal diseases	22
A map of the altered glioma metabolism	22
The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis	21
Topical Microbial Therapeutics against Respiratory Viral Infections	21
Bridging rapid and sustained antidepressant effects of ketamine	21
The ubiquitin–proteasome system in breast cancer	21
Maternal obesity: new placental paradigms unfolded	21
Epigenetic regulation in intervertebral disc degeneration	21
mRNA therapeutics: beyond vaccine applications	21
Brain gene therapy with Trojan horse lipid nanoparticles	21
Breakthroughs and bottlenecks in autophagy research	21
Historical Perspective of Clinical Nano and Microparticle Formulations for Delivery of Therapeutics	20
Fibroblasts in pancreatic cancer: molecular and clinical perspectives	20
Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance	20
Ectopic Lymphoid Organs and Immune-Mediated Diseases: Molecular Basis for Pharmacological Approaches	19
iPSCs and DRGs: stepping stones to new pain therapies	19
Predicting and Overcoming Taxane Chemoresistance	18
The NRF2/Keap1 pathway as a therapeutic target in inflammatory bowel disease	18
Dietary interventions and precision nutrition in cancer therapy	18
Molecular Mechanisms and Treatment Options of Nephropathic Cystinosis	18
How aging impacts vaccine efficacy: known molecular and cellular mechanisms and future directions	18
COVID-19 vaccines in pregnancy	18
Clock-modulated checkpoints in time-restricted eating	18
The spike hypothesis in vaccine-induced adverse effects: questions and answers	18
Organoids, Where We Stand and Where We Go	18
Role of inflammasomes in HIV-1 infection and treatment	17
Unlocking the potential of agonist antibodies for treating cancer using antibody engineering	17
Mining Helminths for Novel Therapeutics	17
Stratum corneum as polymer sheet: concept and cornification processes	17
ROS/RNS as molecular signatures of chronic liver diseases	17
Nasal vaccines: solutions for respiratory infectious diseases	16
ERα in the Control of Mitochondrial Function and Metabolic Health	16
CircRNA perspective: new strategies for RNA therapy	16
Unleashing cell-penetrating peptide applications for immunotherapy	16
Omaveloxolone: a groundbreaking milestone as the first FDA-approved drug for Friedreich ataxia	16
Future medicine: from molecular pathways to the collective intelligence of the body	16
Particulate matter and Alzheimer’s disease: an intimate connection	16
DNA Damage Repair Deficiency and Synthetic Lethality for Cancer Treatment	16
Nutrition interventions in congenital disorders of glycosylation	16
Molecular disease mechanisms of human antineuronal monoclonal autoantibodies	16
CGRP Receptor Antagonism in COVID-19: Potential Cardiopulmonary Adverse Effects	16
Cellular senescence in neuroinflammatory disease: new therapies for old cells?	16
Advances in Inflammasome Research: Recent Breakthroughs and Future Hurdles	15
Understanding the tuberculosis granuloma: the matrix revolutions	15
Cell-free circulating tumor DNA profiling in cancer management	15
PIK3CA-related overgrowth: silver bullets from the cancer arsenal?	15
In Utero Gene Therapy: Progress and Challenges	15
Biological principles of adult degenerative scoliosis	14
NK cells in the brain: implications for brain tumor development and therapy	14
Developing Novel Tests to Screen for Fetal Growth Restriction	14
Polycystic kidney disease: novel insights into polycystin function	14
Erythrophagocytes in hemolytic anemia, wound healing, and cancer	14
siRNA modification and delivery for drug development	14
Microglia–T cell conversations in brain cancer progression	14
d-Amino acids: new clinical pathways for brain diseases	14

Recent insights into lysosomal acid lipase deficiency	14
The microbiome, guard or threat to infant health	14
Deciphering the Identity of Renin Cells in Health and Disease	14
Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease	13
Pushing the boundaries of brain organoids to study Alzheimer’s disease	13
Biodiversity: the overlooked source of human health	13
Rejuvenating the human gut microbiome	13
Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates	13
The sense of antisense therapies in ALS	13
Environmental perception and control of gastrointestinal immunity by the enteric nervous system	13
Meeting the needs of patients with ultrarare diseases	13
Methodological considerations for circulating long noncoding RNA quantification	12
A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes	12
A call for disability health curricula in medical schools	12
Molecular basis and clinical implications of HIFs in cardiovascular diseases	12
Antibody signatures in inflammatory bowel disease: current developments and future applications	12
Cutaneous neuroimmune crosstalk in pruritus	11
Modeling glioblastoma complexity with organoids for personalized treatments	11
Medical education empowered by generative artificial intelligence large language models	11
Strategies to Identify Genetic Variants Causing Infertility	11
Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies	11
Choroideremia: molecular mechanisms and therapies	11
Ubiquitin-modifying enzymes as regulators of colitis	11
The variant landscape and function of DDX3X in cancer and neurodevelopmental disorders	11
Therapeutic Opportunities for Repair GPCRs during Intestinal Mucosal Wound Healing	11
Clinical implications of vitamin B12 as redox-active cofactor	11
Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery	10
Immunogenicity of SARS-CoV-2 vaccines in patients with cancer	10
Drug Discovery Inspired from Nuclear Receptor Sensing of Microbial Signals	10
Oligodendrocyte pathology in Huntington’s disease: from mechanisms to therapeutics	10
IL-33–ILC2 axis in the female reproductive tract	10
Nerve–stem cell crosstalk in skin regeneration and diseases	10
Cellular Models and High-Throughput Screening for Genetic Causality of Intellectual Disability	10
Targeting ACC for NASH resolution	10
Updates and advances in pyruvate kinase deficiency	10
Secondary failure: immune responses to approved protein therapeutics	10
Three ‘E’ challenges for siRNA drug development	10
Control of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Cancer	10
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart	9
Epigenetic priming in neurodevelopmental disorders	9
Immunobiology of pregnancy: from basic science to translational medicine	9
RNA Therapeutics Are Stepping Out of the Maze	9
Primary cilia shape hallmarks of health and aging	9
Translating osteoarthritis genetics research: challenging times ahead	9
AMPK is mitochondrial medicine for neuromuscular disorders	9
Gene-based delivery of immune-activating cytokines for cancer treatment	9
Acting on ethics and governance of aging research	9
Telomere biology disorders: time for moving towards the clinic?	9
Microbiome-targeted interventions for the control of oral–gut dysbiosis and chronic systemic inflammation	9
Integrating single-cell genomics pipelines to discover mechanisms of stem cell differentiation	9
Leveraging cellular mechano-responsiveness for cancer therapy	9
Cell-based regenerative medicine for renovascular disease	8
Focused ultrasound gene delivery for the treatment of neurological disorders	8
AAV-Mediated Gene Therapy for Glycosphingolipid Biosynthesis Deficiencies	8
Novel Therapies for Pneumonia-Associated Severe Asthma Phenotypes	8
Calpains as mechanistic drivers and therapeutic targets for ocular disease	8
Compartmentalization and regulation of GTP in control of cellular phenotypes	8
Transplantation of neural progenitor cells into the human CNS	8
Transmission of Polycystic Ovary Syndrome via Epigenetic Inheritance	8
Human autophagy measurement: an underappreciated barrier to translation	8
Nanobodies as a powerful platform for biomedicine	7
Mitigating age-related somatic mutation burden	7
Accelerated Approval or Risk Reduction? How Response Biomarkers Advance Therapeutics through Clinical Trials in Cystic Fibrosis	7
Asthma exacerbations: the Achilles heel of asthma care	7
Circadian Angiopoietin-Like-4 as a Novel Therapy in Cardiovascular Disease	7
Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality	7
Alternative splicing: a bridge connecting NAFLD and HCC	7
Hyperthermia–embolization–immunotherapy: a potent trio in advancing cancer treatment	7
Delivery of therapeutic AAV9 vectors via cisterna magna to treat neurological disorders	7
New strategies for the treatment of chronic hepatitis B	7
Opportunities and challenges for biomarker discovery using electronic health record data	7
A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies	6
Unmasking BACE1 in aging and age-related diseases	6
Blocking CTGF-Mediated Tumor–Stroma Interplay in Pancreatic Cancer	6
Engineering of the microenvironment to accelerate vascular regeneration	6
Proteome balance in ciliopathies: the OFD1 protein example	6
PARsylation-mediated ubiquitylation: lessons from rare hereditary disease Cherubism	6
LDL-C augments whereas HDL-C prevents inflammatory innate immune memory	6
Engineering Strategies for Allogeneic Solid Tissue Acceptance	6
Harnessing the healing power of love	6
Convalescent plasma to deliver therapeutic antibodies against COVID-19	6
Antibody class-switching as a strategy to improve HIV-1 neutralization	6
Adaptive immune cell responses as therapeutic targets in antibody-mediated organ rejection	6
Diabetes: a tipping point in neurodegenerative diseases	6
ARID1A mutations in lung cancer: biology, prognostic role, and therapeutic implications	6
InFUSing antisense oligonucleotides for treating ALS	6
Monoamines' role in islet cell function and type 2 diabetes risk	6
Imaging genomics: data fusion in uncovering disease heritability	6
The Autoantigen Repertoire and the Microbial RNP World	6
Human dopaminergic system in the exercise-cognition link	6
Localized immunomodulation technologies to enable cellular and organoid transplantation	6
Disease association and therapeutic routes of aminoacyl-tRNA synthetases	6
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation	6
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients	6
CXCR2 chemokine receptor – a master regulator in cancer and physiology	5