OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Immunology is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis	847
Turning cold tumors hot: from molecular mechanisms to clinical applications	238
Macrophage diversity in cancer revisited in the era of single-cell omics	236
A Potential Role of Interleukin 10 in COVID-19 Pathogenesis	232
NF-κB: blending metabolism, immunity, and inflammation	210
The ‘cytokine storm’: molecular mechanisms and therapeutic prospects	204
Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines	155
T Cells: Warriors of SARS-CoV-2 Infection	143
Tolerogenic Dendritic Cells in Autoimmunity and Inflammatory Diseases	140
VISTA: A Mediator of Quiescence and a Promising Target in Cancer Immunotherapy	122
Cytokine-skewed Tfh cells: functional consequences for B cell help	111
Unraveling B cell trajectories at single cell resolution	110
Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)	107
Early clues regarding the pathogenesis of long-COVID	98
Tissue-resident macrophages: guardians of organ homeostasis	92
Dual Nature of Type I Interferons in SARS-CoV-2-Induced Inflammation	88
Single B cell technologies for monoclonal antibody discovery	86
Transcription Factor Bhlhe40 in Immunity and Autoimmunity	83
Immune imprinting and SARS-CoV-2 vaccine design	81
Polyamines and Kynurenines at the Intersection of Immune Modulation	81
Decoding the Heterogeneity of Human Dendritic Cell Subsets	80
Monocyte Regulation in Homeostasis and Malignancy	80
Structural Basis of SARS-CoV-2 and SARS-CoV Antibody Interactions	79
RORγt protein modifications and IL-17-mediated inflammation	78
Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment	76

Predicting and Preventing Immune Checkpoint Inhibitor Toxicity: Targeting Cytokines	75
CD4+ T cells that help B cells – a proposal for uniform nomenclature	74
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy	74
The cholesterol pathway: impact on immunity and cancer	74
Emerging mechanisms of immunocoagulation in sepsis and septic shock	63
Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions	61
Context-Dependent Glioblastoma–Macrophage/Microglia Symbiosis and Associated Mechanisms	59
Maternal inflammation and its ramifications on fetal neurodevelopment	54
Differential roles of interferons in innate responses to mucosal viral infections	51
Sodium and its manifold impact on our immune system	51
Lymph node fibroblastic reticular cells steer immune responses	51
K63 ubiquitination in immune signaling	51
Diversity and Function of Glial Cell Types in Multiple Sclerosis	50
LFA-1 in T cell priming, differentiation, and effector functions	48
New insights into TCR β-selection	46
The tetraspan MS4A family in homeostasis, immunity, and disease	45
The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics	45
Host immunity and cellular responses to bacterial outer membrane vesicles	43
Combining Antivirals and Immunomodulators to Fight COVID-19	43
Tissue-specific differentiation of CD8+ resident memory T cells	41
Complement Factors in COVID-19 Therapeutics and Vaccines	40
ADAR1 and ZBP1 in innate immunity, cell death, and disease	40
Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks	39
NF-κB and Extrinsic Cell Death Pathways – Entwined Do-or-Die Decisions for T cells	38
Succinate Receptor 1: An Emerging Regulator of Myeloid Cell Function in Inflammation	38
Neuroimmune cleanup crews in brain injury	37
Unleashing TNF cytotoxicity to enhance cancer immunotherapy	37
The NLRP3 inflammasome: regulation by metabolic signals	36
Decoding the dynamics of multilayered stochastic antiviral IFN-I responses	35
OTULIN in NF-κB signaling, cell death, and disease	35
Hematopoiesis in numbers	35
The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder	34
Understanding mast cell heterogeneity at single cell resolution	34
The heightened importance of the microbiome in cancer immunotherapy	34
Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers	33
Parkinson's disease: connecting mitochondria to inflammasomes	33
NAD+ in COVID-19 and viral infections	33
Guillain-Barré syndrome: expanding the concept of molecular mimicry	33
Cell death checkpoints in the TNF pathway	33
Metabolic regulation of the cancer-immunity cycle	32
NLRP3 inflammasomes that induce antitumor immunity	32
Enemy or ally? Fasting as an essential regulator of immune responses	31
Emerging roles of Dectin-1 in noninfectious settings and in the CNS	31
Lipid regulation of NLRP3 inflammasome activity through organelle stress	31
Macrophage immunotherapy: overcoming impediments to realize promise	30
C3-targeted therapy in periodontal disease: moving closer to the clinic	30
Systemic Immunoregulatory Consequences of Gut Commensal Translocation	30
BCG vaccination induces cross-protective immunity against pathogenic microorganisms	29
Developing pan-β-coronavirus vaccines against emerging SARS-CoV-2 variants of concern	28
Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunity	28

Tick host immunity: vector immunomodulation and acquired tick resistance	26
Conditioning of the immune system by the microbiome	26
Early Events Triggering the Initiation of a Type 2 Immune Response	26
Lighting up the tumor fire with low-dose irradiation	26
ATM: Translating the DNA Damage Response to Adaptive Immunity	25
TCR-sequencing in cancer and autoimmunity: barcodes and beyond	25
Testicular macrophages: development and function in health and disease	25
Metabolism and epigenetics at the heart of T cell function	25
T Cell Development: Old Tales Retold By Single-Cell RNA Sequencing	25
Multiple sclerosis: role of meningeal lymphoid aggregates in progression independent of relapse activity	24
Lymph node stromal cells: subsets and functions in health and disease	24
Oxidized mitochondrial DNA: a protective signal gone awry	24
NF-κB dynamics in the language of immune cells	23
Genes, Environments, and Phenotypic Plasticity in Immunology	23
Genetic and hormonal mechanisms underlying sex-specific immune responses in tuberculosis	22
Metabolites and secretory immunoglobulins: messengers and effectors of the host–microbiota intestinal equilibrium	22
The Paradoxical Roles of Inflammation during PD-1 Blockade in Cancer	22
The evolutionary and functional significance of germline immunoglobulin gene variation	22
Immunomodulatory impact of α-fetoprotein	22
Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis	21
Programming cytomegalovirus as an HIV vaccine	21
How metabolism bridles cytotoxic CD8+ T cells through epigenetic modifications	21
Tumor microenvironment metabolites directing T cell differentiation and function	20
Synovial macrophages: from ordinary eaters to extraordinary multitaskers	19
SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences	19
Targeting butyrophilins for cancer immunotherapy	19
Thymic mimetic cells: tolerogenic masqueraders	19
Natural resistance against infections: focus on COVID-19	18
Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond	18
Zebrafish: an underutilized tool for discovery in host–microbe interactions	18
All is not lost: learning from 9p21 loss in cancer	18
Developing cultural humility in immunology and STEMM mentoring	18
LNCing RNA to immunity	18
Transcription factor-driven regulation of ILC1 and ILC3	18
Friendly fungi: symbiosis with commensal Candida albicans	18
Type 1 conventional dendritic cells: ontogeny, function, and emerging roles in cancer immunotherapy	18
Baby’s skin bacteria: first impressions are long-lasting	18
Antigen presentation by MHC-E: a putative target for vaccination?	17
Obesity and dysregulated innate immune responses: impact of micronutrient deficiencies	17
miRNA effects on gut homeostasis: therapeutic implications for inflammatory bowel disease	17
An ordeal that does not heal: understanding barriers to a cure for HIV-1 infection	17
The cancer cell-derived extracellular vesicle glycocode in immunoevasion	17
Targeting Skin-Resident Memory T Cells via Vaccination to Combat Staphylococcus aureus Infections	17
Noradrenergic Signaling and Neuroinflammation Crosstalk Regulate Toxoplasma gondii-Induced Behavioral Changes	17
Type 2 immunity: a two-edged sword in schistosomiasis immunopathology	17
pH sensing at the intersection of tissue homeostasis and inflammation	17
Cell-intrinsic view of the aryl hydrocarbon receptor in tumor immunity	16
Gata6+ large peritoneal macrophages: an evolutionarily conserved sentinel and effector system for infection and injury	16
SARS-CoV-2 vaccination washes away original antigenic sin	16
Deconstructing iNKT cell development at single-cell resolution	16
Lymph node lymphatic endothelial cells as multifaceted gatekeepers in the immune system	16
Innate antiviral immunity: how prior exposures can guide future responses	16
Putative role of STING-mitochondria associated membrane crosstalk in immunity	15
Human milk oligosaccharides: potential therapeutic aids for allergic diseases	15
Memory B cell diversity: insights for optimized vaccine design	15
Interrogating immune cells and cancer with CRISPR-Cas9	15
Physiological role of cytokines in the regulation of mammalian metabolism	15
Taking T-Cell Oncotherapy Off-the-Shelf	15
Targeting Th17 cells in HIV-1 remission/cure interventions	15
High endothelial venules as potential gateways for therapeutics	14
New insights into transcription elongation control of HIV-1 latency and rebound	14
The Roles of T cells in Bladder Pathologies	14
The evolution of powerful yet perilous immune systems	14
Carbohydrates in allergy: from disease to novel immunotherapies	14
Malaria: influence of Anopheles mosquito saliva on Plasmodium infection	14