Trends in Immunology

Article	Citations
Advisory Board and Contents	428
Advisory Board and Contents	353
Advisory Board and Contents	340
Subscription and Copyright Information	299
Tensor-based insights into systems immunity and infectious disease	180
DNA flexibility can shape the preferential hypermutation of antibody genes	161
Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?	147
Dietary fibers affecting gastrointestinal immunity	138
Unleashing dendritic cell-mediated tumor clearance by targeting Bcl-2	127
On tending sprouts: empowering emerging immunologists in Latin America	119
Emerging roles of Dectin-1 in noninfectious settings and in the CNS	112
Lymph node stromal cells: subsets and functions in health and disease	104
Ragulator-Rag and ROS TORment gasdermin D pore formation	101
Novel insights and recent progress in osteoimmunology	94
Metabolic and stress response adaptations in T cells to fever and physiological heat	92
Innate immunity: the bacterial connection	84
Contribution of gut-derived T cells to extraintestinal autoimmune diseases	77
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EmBmem: will the real memory B cell please stand up?	73
Loss of ARID1A ‘loops’ in STING	71
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections	67
Oxidative battles in tuberculosis: walking the ferroptotic tightrope	65
Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics	63
Risk factors of cytokine release syndrome: stress, catecholamines, and beyond	63
The tumor niche can reprogram long-lived protumorigenic neutrophils	63

Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis	62
Inflammatory and immune etiology of type 2 diabetes	61
BCR signaling in germinal center B cell selection	59
DNA at the center of mammalian innate immune recognition of bacterial biofilms	59
Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine	57
Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy?	56
Agents of cancer immunosurveillance: HSPs and dsDNA	56
The five senses of immunity	52
Context-dependent regulation of follicular helper T cell survival	52
Subscription and Copyright Information	51
Leveraging community engagement to shape biomedical research priorities	50
Infusion of neutralization into Lassa vaccine design	49
Cytosolic delivery of innate immune agonists	49
Tumor microenvironment metabolites directing T cell differentiation and function	48
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology	48
Targeting Th17 cells in HIV-1 remission/cure interventions	46
High endothelial venules as potential gateways for therapeutics	45
Genotype–phenotype landscapes for immune–pathogen coevolution	45
Microglia as integrators of brain-associated molecular patterns	43
Unanticipated specificity in effector-triggered immunity	43
The translational potential of studying bat immunity	43
Advisory Board and Contents	42
Maternal inflammation and its ramifications on fetal neurodevelopment	42
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Astrocytes ACLYmate to chronic neuroinflammation	40
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Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens	40
Antigen presentation by MHC-E: a putative target for vaccination?	39
Natural resistance against infections: focus on COVID-19	39
Intracellular C1q – an unexpected player in neuronal proteostasis	39
B cells masquerade as dendritic cells	38
Original antigenic sin: not so sinful after all	38
Bridging anatomical gaps between brain and immune system	36
Immune evasion in ovarian cancer: implications for immunotherapy and emerging treatments	36
Monoallelic expression in human immune cells: linking genotype to phenotype	35
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The complex immunological role of Helicobacter in modulating cancer	33
TLR9 triggers MyD88-independent anti-inflammatory signaling in lupus	33
Spiking SARS-CoV-2 antiviral immunity in the respiratory tract	32
Emerging roles for tRNAs in hematopoiesis and hematological malignancies	32
LNCing RNA to immunity	32
Lymphoid tissue on the mind	30
Calreticulin surface presentation can promote quality control of hematopoietic stem cells	30
Old macrophages lose their (circadian) rhythm	30
Advisory Board and Contents	29
Advisory Board and Contents	29
Transcription factor-driven regulation of ILC1 and ILC3	29
Advisory Board and Contents	29

Signaling is the pathway to macrophage function	29
Protists protecting food tolerance	28
Gut microbiota–host post-translational modification axis in immunometabolic diseases	27
Putative role of STING-mitochondria associated membrane crosstalk in immunity	27
Targeting the metabolism of tumor-infiltrating regulatory T cells	27
Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities	27
Exploring mucosal immune development and function in utero	27
Chimeric antigen receptor Treg therapy in transplantation	26
Advisory Board and Contents	26
Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers	26
Advisory Board and Contents	26
Subscription and Copyright Information	25
Subscription and Copyright Information	25
Sensory nerves unlock the TOLL-7 gate for cancer spread	25
The predictive power of systems immunology	25
Harder, better, faster, stronger: biochemistry and biophysics in the immunosurveillance concert	25
Protect, repair, rewire, and defend	25
Immune-featured decidual stromal cells: pregnancy's multitasking superstars	24
Immunotherapy response-associated Akkermansia: canary in a coal mine?	23
Regulation and impact of tumor-specific CD4+ T cells in cancer and immunotherapy	23
Th17 cells: from gut homeostasis to CNS pathogenesis	23
Multiple sclerosis: role of meningeal lymphoid aggregates in progression independent of relapse activity	23
Sensory neuronal control of skin barrier immunity	23
BCG vaccination induces cross-protective immunity against pathogenic microorganisms	23
TCR-sequencing in cancer and autoimmunity: barcodes and beyond	23
Overcoming gender bias in STEM	23
CD8+ Tregs kill pathogenic cells to avert autoimmunity	22
New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies	22
How do autoimmune CD4+ T cells handle exhaustion?	22
The diversity of cGLR receptors: shedding new light on innate immunity	22
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy	22
COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle	22
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Feeding the wrath with myelin	21
Inflammasome diversity: exploring novel frontiers in the innate immune response	21
Life and death of tolerogenic dendritic cells	21
Partners and guardians of the nervous and immune systems	21
Repurposing of old drugs for unleashing innate immunity	20
Development of a circadian immune system	20
B cell phylogenetics in the single cell era	20
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases	20
Lymph node fibroblast-produced extracellular matrix shapes immune function	19
RORγt protein modifications and IL-17-mediated inflammation	19
Finding your niche: immune evasion in quiescent tumor reservoirs	18
cGAS-like receptors: back to the future	18
SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences	18
The extracellular matrix and immunity: breaking the old barrier in cancer	18
Why are there so few (or so many) circulating coronaviruses?	17
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis	17
Advisory Board and Contents	17
Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunity	17
Early clues regarding the pathogenesis of long-COVID	17
Human neutrophil kinetics: a call to revisit old evidence	17
Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment	17
ICOS-play: dressing T cells for residency	17
Exhausted CD8+ T cells face a developmental fork in the road	16
RNA circuits and RNA-binding proteins in T cells	16
Breaking down IgA: Tomasiella immunophila enlightens microbiome–immune interactions	15
Lipid regulation of NLRP3 inflammasome activity through organelle stress	15
Physiological role of cytokines in the regulation of mammalian metabolism	15
Inflammasomopathies: mechanisms and disease signatures	15
Neuro–immune crosstalk: focus on innate lymphoid cells	15
Macrophage states: there's a method in the madness	15
Unraveling B cell trajectories at single cell resolution	14
Turning cold tumors hot: from molecular mechanisms to clinical applications	14
Prenatal inflammation shapes microglial immune response into adulthood	14
Advisory Board and Contents	14
CD4+ T cells that help B cells – a proposal for uniform nomenclature	14
Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?	14
Cancer germline antigens and tumor-agnostic CD8+ T cell evasion	14
Restriction factors regulating human herpesvirus infections	14
A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development	14
T cell TET2 disruption cuts the breaks on antitumor CAR T cell therapy	14
Channel plan: control of adaptive immune responses by pannexins	14
Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine	13
The T cell subsetting challenge	13
Zebrafish: an underutilized tool for discovery in host–microbe interactions	13
New insights into transcription elongation control of HIV-1 latency and rebound	13
Unleashing TNF cytotoxicity to enhance cancer immunotherapy	13
Baby’s skin bacteria: first impressions are long-lasting	13

The meningeal lymphatics: regulators of Aβ immunotherapy?	12
Advisory Board and Contents	12
Monoclonal antibodies lock down SARS-CoV-2 spike	12
Advisory Board and Contents	12
Advisory Board and Contents	12
Subscription and Copyright Information	12
Trust your gut: an early life lesson for T cells	11
Enhancing tumor immunity via in vivo cDC1 reprogramming	11
Microglia replacement: from monocytic origin to therapy	11
Cryptic but critical: non-canonical antigens in cancer immunotherapy	11
Towards a quantitative theory of tolerance	11
Approaches for studying neuroimmune interactions in Alzheimer’s disease	11
Developing cultural humility in immunology and STEMM mentoring	11
Uniting innate and adaptive immunity in glioblastoma; an α-CTLA-4 quest	11
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Affinity-independent plasma cell differentiation in germinal centers	11
Using TCR-CAR dual signaling for precise cancer targeting	11
Humans pIKK-up NLRP3 to skip NEK7	11
Introducing the 'Significance' box in Trends in Immunology articles	11
Regional specialization within the mammalian respiratory immune system	10
Aching to defend: spleen innervation drives humoral immunity	10
Host immunity and cellular responses to bacterial outer membrane vesicles	10
SARS-CoV-2 vaccination washes away original antigenic sin	10
Ghrelin and leptin regulating wound healing	10
Malaria: influence of Anopheles mosquito saliva on Plasmodium infection	10
Inflammatory and immune effects on tumor progression	10
Locus architecture and RAG scanning determine antibody diversity	10
Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond	9
Memory B cell diversity: insights for optimized vaccine design	9
Advisory Board and Contents	9
Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus	9
Mutagenic repair during antibody diversification: emerging insights	9
Deciphering SARS-CoV-2 evolution under antibody immune pressure	9
Gutsy sensations modulate intestinal disease	9
Genetic conflicts and the origin of self/nonself-discrimination in the vertebrate immune system	9
Targeting immune evasion in hepatocellular carcinoma-initiating cells	9
Multiscale geometric and topological analyses for characterizing and predicting immune responses from single cell data	9
Subscription and Copyright Information	9
Subscription and Copyright Information	9
Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death	8
Structure-based mechanisms of 2′3′-cGAMP intercellular transport in the cGAS–STING immune pathway	8
Advisory Board and Contents	8
Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks	8
Enlightening Per2-suasive role of neutrophils in antibacterial immunity	8
ADAR1 and ZBP1 in innate immunity, cell death, and disease	8
Embryonic microglia maintain the brain's cortical fault lines	8
Microglia pack a toolbox for life	8
Pseudomonas aeruginosa: a pathogen making itself at home	8
The Vibrio cholerae maneuver	8
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Over but not gone: lingering epigenetic effects of COVID-19	7
Lung tumor immunity: redirecting macrophages through infection-induced inflammation	7
The putative contribution of cellular senescence to driving tauopathies	7
C3-targeted therapy in periodontal disease: moving closer to the clinic	7
Helper ILCs in the human hematopoietic system	7
Immunomodulatory impact of α-fetoprotein	6
Boosting peripheral immunity to fight neurodegeneration in the brain	6
Decoding microglial functions in Alzheimer’s disease: insights from human models	6
Oxidative stress, malaria, sickle cell disease, and innate immunity	6
Advisory Board and Contents	6
Tracking tumor-specific CD8+ T cell responses	6
Deconstructing iNKT cell development at single-cell resolution	6
Leveraging deep learning to improve vaccine design	6
Towards decoding the space-time continuum of pregnancy	6
Recombinant snake antivenoms get closer to the clinic	6
Advisory Board and Contents	6
Complement(ing) long-COVID thromboinflammation and pathogenesis	6
Approaches for studying human macrophages	6
Diet and immune response: how today’s plate shapes tomorrow’s health	6
The heightened importance of the microbiome in cancer immunotherapy	6
The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder	6
Allogeneic hematopoietic stem cell transplantation: lessons learned by a molecular immunologist/transplant patient	6
Macrophage immunotherapy: overcoming impediments to realize promise	5
NF-κB: blending metabolism, immunity, and inflammation	5
Beyond antiviral: role of IFN-I in brain development	5
On developmental programming of the immune system	5
Why do central nervous system barriers host a diverse immune landscape?	5
Modeling human immune responses to vaccination in vitro	5
Advisory Board and Contents	5
One degree of separation: urgent questions surrounding new USA laws in women’s healthcare	5
Advisory Board and Contents	5
Tissue-specific differentiation of CD8+ resident memory T cells	5
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Leveraging human immune organoids for rational vaccine design	5
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Liquid–liquid phase separation in innate immunity	4
Sterols in asthma	4
Emerging roles of astrocytes as immune effectors in the central nervous system	4
Advisory Board and Contents	4
DNA repair and antibody diversification: the 53BP1 paradigm	4
The extracellular matrix in solid tumor immunotherapy	4
Mutant ARID1A: igniting cancer immunotherapy	4
Modulation of host immunity by sensory neurons	4
Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond	4
Single B cell technologies for monoclonal antibody discovery	4