Trends in Immunology

Article	Citations
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis	847
Turning cold tumors hot: from molecular mechanisms to clinical applications	238
Macrophage diversity in cancer revisited in the era of single-cell omics	236
A Potential Role of Interleukin 10 in COVID-19 Pathogenesis	232
NF-κB: blending metabolism, immunity, and inflammation	210
The ‘cytokine storm’: molecular mechanisms and therapeutic prospects	204
Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines	155
T Cells: Warriors of SARS-CoV-2 Infection	143
Tolerogenic Dendritic Cells in Autoimmunity and Inflammatory Diseases	140
VISTA: A Mediator of Quiescence and a Promising Target in Cancer Immunotherapy	122
Cytokine-skewed Tfh cells: functional consequences for B cell help	111
Unraveling B cell trajectories at single cell resolution	110
Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)	107
Early clues regarding the pathogenesis of long-COVID	98
Tissue-resident macrophages: guardians of organ homeostasis	92
Dual Nature of Type I Interferons in SARS-CoV-2-Induced Inflammation	88
Single B cell technologies for monoclonal antibody discovery	86
Transcription Factor Bhlhe40 in Immunity and Autoimmunity	83
Polyamines and Kynurenines at the Intersection of Immune Modulation	81
Immune imprinting and SARS-CoV-2 vaccine design	81
Decoding the Heterogeneity of Human Dendritic Cell Subsets	80
Monocyte Regulation in Homeostasis and Malignancy	80
Structural Basis of SARS-CoV-2 and SARS-CoV Antibody Interactions	79
RORγt protein modifications and IL-17-mediated inflammation	78
Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment	76

Predicting and Preventing Immune Checkpoint Inhibitor Toxicity: Targeting Cytokines	75
The cholesterol pathway: impact on immunity and cancer	74
CD4+ T cells that help B cells – a proposal for uniform nomenclature	74
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy	74
Emerging mechanisms of immunocoagulation in sepsis and septic shock	63
Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions	61
Context-Dependent Glioblastoma–Macrophage/Microglia Symbiosis and Associated Mechanisms	59
Maternal inflammation and its ramifications on fetal neurodevelopment	54
Sodium and its manifold impact on our immune system	51
Lymph node fibroblastic reticular cells steer immune responses	51
K63 ubiquitination in immune signaling	51
Differential roles of interferons in innate responses to mucosal viral infections	51
Diversity and Function of Glial Cell Types in Multiple Sclerosis	50
LFA-1 in T cell priming, differentiation, and effector functions	48
New insights into TCR β-selection	46
The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics	45
The tetraspan MS4A family in homeostasis, immunity, and disease	45
Combining Antivirals and Immunomodulators to Fight COVID-19	43
Host immunity and cellular responses to bacterial outer membrane vesicles	43
Tissue-specific differentiation of CD8+ resident memory T cells	41
ADAR1 and ZBP1 in innate immunity, cell death, and disease	40
Complement Factors in COVID-19 Therapeutics and Vaccines	40
Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks	39
Succinate Receptor 1: An Emerging Regulator of Myeloid Cell Function in Inflammation	38
NF-κB and Extrinsic Cell Death Pathways – Entwined Do-or-Die Decisions for T cells	38
Unleashing TNF cytotoxicity to enhance cancer immunotherapy	37
Neuroimmune cleanup crews in brain injury	37
The NLRP3 inflammasome: regulation by metabolic signals	36
Hematopoiesis in numbers	35
Decoding the dynamics of multilayered stochastic antiviral IFN-I responses	35
OTULIN in NF-κB signaling, cell death, and disease	35
The heightened importance of the microbiome in cancer immunotherapy	34
The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder	34
Understanding mast cell heterogeneity at single cell resolution	34
Guillain-Barré syndrome: expanding the concept of molecular mimicry	33
Cell death checkpoints in the TNF pathway	33
Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers	33
Parkinson's disease: connecting mitochondria to inflammasomes	33
NAD+ in COVID-19 and viral infections	33
NLRP3 inflammasomes that induce antitumor immunity	32
Metabolic regulation of the cancer-immunity cycle	32
Emerging roles of Dectin-1 in noninfectious settings and in the CNS	31
Lipid regulation of NLRP3 inflammasome activity through organelle stress	31
Enemy or ally? Fasting as an essential regulator of immune responses	31
C3-targeted therapy in periodontal disease: moving closer to the clinic	30
Systemic Immunoregulatory Consequences of Gut Commensal Translocation	30
Macrophage immunotherapy: overcoming impediments to realize promise	30
BCG vaccination induces cross-protective immunity against pathogenic microorganisms	29
Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunity	28
Developing pan-β-coronavirus vaccines against emerging SARS-CoV-2 variants of concern	28

Lighting up the tumor fire with low-dose irradiation	26
Tick host immunity: vector immunomodulation and acquired tick resistance	26
Conditioning of the immune system by the microbiome	26
Early Events Triggering the Initiation of a Type 2 Immune Response	26
Metabolism and epigenetics at the heart of T cell function	25
T Cell Development: Old Tales Retold By Single-Cell RNA Sequencing	25
ATM: Translating the DNA Damage Response to Adaptive Immunity	25
TCR-sequencing in cancer and autoimmunity: barcodes and beyond	25
Testicular macrophages: development and function in health and disease	25
Oxidized mitochondrial DNA: a protective signal gone awry	24
Multiple sclerosis: role of meningeal lymphoid aggregates in progression independent of relapse activity	24
Lymph node stromal cells: subsets and functions in health and disease	24
Genes, Environments, and Phenotypic Plasticity in Immunology	23
NF-κB dynamics in the language of immune cells	23
The evolutionary and functional significance of germline immunoglobulin gene variation	22
Immunomodulatory impact of α-fetoprotein	22
Genetic and hormonal mechanisms underlying sex-specific immune responses in tuberculosis	22
Metabolites and secretory immunoglobulins: messengers and effectors of the host–microbiota intestinal equilibrium	22
The Paradoxical Roles of Inflammation during PD-1 Blockade in Cancer	22
How metabolism bridles cytotoxic CD8+ T cells through epigenetic modifications	21
Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis	21
Programming cytomegalovirus as an HIV vaccine	21
Tumor microenvironment metabolites directing T cell differentiation and function	20
Thymic mimetic cells: tolerogenic masqueraders	19
Synovial macrophages: from ordinary eaters to extraordinary multitaskers	19
SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences	19
Targeting butyrophilins for cancer immunotherapy	19
Friendly fungi: symbiosis with commensal Candida albicans	18
Type 1 conventional dendritic cells: ontogeny, function, and emerging roles in cancer immunotherapy	18
Baby’s skin bacteria: first impressions are long-lasting	18
Natural resistance against infections: focus on COVID-19	18
Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond	18
Zebrafish: an underutilized tool for discovery in host–microbe interactions	18
All is not lost: learning from 9p21 loss in cancer	18
Developing cultural humility in immunology and STEMM mentoring	18
LNCing RNA to immunity	18
Transcription factor-driven regulation of ILC1 and ILC3	18
Noradrenergic Signaling and Neuroinflammation Crosstalk Regulate Toxoplasma gondii-Induced Behavioral Changes	17
Type 2 immunity: a two-edged sword in schistosomiasis immunopathology	17
pH sensing at the intersection of tissue homeostasis and inflammation	17
Antigen presentation by MHC-E: a putative target for vaccination?	17
Obesity and dysregulated innate immune responses: impact of micronutrient deficiencies	17
miRNA effects on gut homeostasis: therapeutic implications for inflammatory bowel disease	17
An ordeal that does not heal: understanding barriers to a cure for HIV-1 infection	17
The cancer cell-derived extracellular vesicle glycocode in immunoevasion	17
Targeting Skin-Resident Memory T Cells via Vaccination to Combat Staphylococcus aureus Infections	17
Lymph node lymphatic endothelial cells as multifaceted gatekeepers in the immune system	16
Innate antiviral immunity: how prior exposures can guide future responses	16
Cell-intrinsic view of the aryl hydrocarbon receptor in tumor immunity	16
Gata6+ large peritoneal macrophages: an evolutionarily conserved sentinel and effector system for infection and injury	16
SARS-CoV-2 vaccination washes away original antigenic sin	16
Deconstructing iNKT cell development at single-cell resolution	16
Taking T-Cell Oncotherapy Off-the-Shelf	15
Targeting Th17 cells in HIV-1 remission/cure interventions	15
Putative role of STING-mitochondria associated membrane crosstalk in immunity	15
Human milk oligosaccharides: potential therapeutic aids for allergic diseases	15
Memory B cell diversity: insights for optimized vaccine design	15
Interrogating immune cells and cancer with CRISPR-Cas9	15
Physiological role of cytokines in the regulation of mammalian metabolism	15
Carbohydrates in allergy: from disease to novel immunotherapies	14
Malaria: influence of Anopheles mosquito saliva on Plasmodium infection	14
High endothelial venules as potential gateways for therapeutics	14
New insights into transcription elongation control of HIV-1 latency and rebound	14
The Roles of T cells in Bladder Pathologies	14
The evolution of powerful yet perilous immune systems	14
Short open reading frame genes in innate immunity: from discovery to characterization	13
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies	13
Clash of the titans: interferons and SARS-CoV-2	13
Harnessing prostaglandin E2 signaling to ameliorate autoimmunity	13
Exhausted CD8+ T cells face a developmental fork in the road	13
Human neutrophil kinetics: a call to revisit old evidence	13
Targeting the metabolism of tumor-infiltrating regulatory T cells	13
Immune defenses in the urinary tract	13
Shaped by the epithelium – postnatal immune mechanisms of oral homeostasis	13
Inflammatory and immune etiology of type 2 diabetes	12
Regional specialization of macrophages along the gastrointestinal tract	12
AID in Antibody Diversification: There and Back Again	12
On the Improper Use of the Term High-Density Neutrophils	12
Structure-based mechanisms of 2′3′-cGAMP intercellular transport in the cGAS–STING immune pathway	12
The Role of CD8 Downregulation during Thymocyte Differentiation	11

Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons	11
Zebrafish Models to Study Inflammasome-Mediated Regulation of Hematopoiesis	11
Making human immune systems more interpretable through systems immunology	11
Illuminating Epigenetics and Inheritance in the Immune System with Bioluminescence	11
Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?	11
IL-2-driven CD8+ T cell phenotypes: implications for immunotherapy	11
Insights into how SARS-CoV2 infection induces cytokine storms	10
Context-dependent regulation of follicular helper T cell survival	10
Secreted immune metabolites that mediate immune cell communication and function	10
Life and death of tolerogenic dendritic cells	10
Towards systems immunology of critical illness at scale: from single cell ‘omics to digital twins	10
Lysozyme: A Double-Edged Sword in the Intestine	10
Cancer germline antigens and tumor-agnostic CD8+ T cell evasion	9
Effector-triggered immunity in mammalian antiviral defense	9
Leveraging deep learning to improve vaccine design	9
The impact of age-related hypomethylated DNA on immune signaling upon cellular demise	9
Putative regulation of macrophage-mediated inflammation by catestatin	9
Impact of human CD95 mutations on cell death and autoimmunity: a model	9
Towards regulatory cellular therapies in solid organ transplantation	9
Ragulator-Rag and ROS TORment gasdermin D pore formation	9
Fostering experimental and computational synergy to modulate hyperinflammation	9
Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases	9
Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis	9
Gland Macrophages: Reciprocal Control and Function within Their Niche	9
Linking nutrient sensing, mitochondrial function, and PRR immune cell signaling in liver disease	9
Epigenetic liquid biopsies: a novel putative biomarker in immunology and inflammation	8
The extracellular matrix and immunity: breaking the old barrier in cancer	8
RNA decay machinery safeguards immune cell development and immunological responses	8
‘(m6)A’ stands for ‘autoimmunity’: reading, writing, and erasing RNA modifications during inflammation	8
Examining the cooperativity mode of antibody and CD8+ T cell immune responses for vaccinology	8
Genetic conflicts and the origin of self/nonself-discrimination in the vertebrate immune system	8
Fate-mapping mice: new tools and technology for immune discovery	8
What’s the deal with efferocytosis and asthma?	8
Splicing dysregulation in human hematologic malignancies: beyond splicing mutations	8
Agents of cancer immunosurveillance: HSPs and dsDNA	8
Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications	8
Immune cell cholinergic signaling in adipose thermoregulation and immunometabolism	8
A new perspective on mesenchymal–immune interactions in adipose tissue	7
Archetypes of checkpoint-responsive immunity	7
Systems immunology of regulatory T cells: can one circuit explain it all?	7
Staggered starts in the race to T cell activation	7
Autoimmune thyroid diseases as a cost of physiological autoimmune surveillance	7
Neuro–epithelial–ILC2 crosstalk in barrier tissues	7
Primary cilia and their effects on immune cell functions and metabolism: a model	7
An immune window of opportunity to prevent childhood B cell leukemia	7
Monocyte differentiation within tissues: a renewed outlook	7
The RNA polymerase III–RIG-I axis in antiviral immunity and inflammation	7
How can polyreactive antibodies conquer rapidly evolving viruses?	7
Why are there so few (or so many) circulating coronaviruses?	7
Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity	7
Tfh cells induce intratumoral tertiary lymphoid structures	6
T cell asymmetry and metabolic crosstalk can fine-tune immunological synapses	6
Rationalizing Random Walks: Replicating Protective Antibody Trajectories	6
Regulation and impact of tumor-specific CD4+ T cells in cancer and immunotherapy	6
Keeping T cell memories in mind	6
The meningeal lymphatics: regulators of Aβ immunotherapy?	6
Lipopolysaccharide delivery systems in innate immunity	6
NLRP12 drives PANoptosis in response to heme	6
Th17 cells: from gut homeostasis to CNS pathogenesis	6
Magnesium for T cells: strong to the finish!	6
A model of Th2 differentiation based on polarizing cytokine repression	6
COVID-19 vaccines and a perspective on Africa	6
Antibody-mediated regulation of basophils: emerging views and clinical implications	6
Factors contributing to the potency of CD8+ T cells	6
Targeting MHC-I inhibitory pathways for cancer immunotherapy	6
The potential of mRNA vaccines in cancer nanomedicine and immunotherapy	5
Locked and loaded: strong TCR signaling primes anti-PD-1 therapy	5
B cell phylogenetics in the single cell era	5
Harder, better, faster, stronger: biochemistry and biophysics in the immunosurveillance concert	5
Rifampicin drug resistance and host immunity in tuberculosis: more than meets the eye	5
Ghrelin and leptin regulating wound healing	5
Liquid–liquid phase separation in innate immunity	5
Potential multi-modal effects of provirus integration on HIV-1 persistence: lessons from other viruses	5
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis	5
Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus	5
Microglia pack a toolbox for life	5
Circulating IRF8-expressing CD123+CD127+ lymphoid progenitors: key players in human hematopoiesis	5
Emerging roles for tRNAs in hematopoiesis and hematological malignancies	5
Deregulation of enhancer structure, function, and dynamics in acute lymphoblastic leukemia	5
Gasdermin D triggers cardiolipin-driven mitochondrial damage and pyroptosis	5
Innate immunity: the bacterial connection	5
Brain border-associated macrophages: common denominators in infection, aging, and Alzheimer’s disease?	4
Equity, diversity, and inclusion in academia: lessons from the Canadian Society of Immunology	4
How does the microbiota control systemic innate immunity?	4
Risk factors of cytokine release syndrome: stress, catecholamines, and beyond	4
Conservation and divergence in gene regulation between mouse and human immune cells deserves equal emphasis	4
MDSCs sneak CSCs out of (immuno)surveillance	4
Sterols in asthma	4
Mesoscale T cell antigen discrimination emerges from intercellular feedback	4
Acute Lymphoblastic Leukemia Cell Lines in Immunology Research	4
Cutting edge: interleukin-17a prompts HIF1α for wound healing	4
Modulation of host immunity by sensory neurons	4
Can Microbes Boost Tregs to Suppress Food Sensitivities?	4
Oxidative stress, malaria, sickle cell disease, and innate immunity	4
Tensor-based insights into systems immunity and infectious disease	4