Trends in Immunology

Article	Citations
Subscription and Copyright Information	471
Advisory Board and Contents	391
DNA flexibility can shape the preferential hypermutation of antibody genes	381
Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?	206
Metabolic and stress response adaptations in T cells to fever and physiological heat	192
On tending sprouts: empowering emerging immunologists in Latin America	161
Novel insights and recent progress in osteoimmunology	152
Contribution of gut-derived T cells to extraintestinal autoimmune diseases	148
Unleashing dendritic cell-mediated tumor clearance by targeting Bcl-2	142
Tensor-based insights into systems immunity and infectious disease	122
Innate immunity: the bacterial connection	122
Ragulator-Rag and ROS TORment gasdermin D pore formation	120
Advisory Board and Contents	94
Dietary fibers affecting gastrointestinal immunity	92
Advisory Board and Contents	92
Subscription and Copyright Information	86
‘Smelling’ lipid cues: chemosensory receptors tune tumor-associated macrophage behavior	81
Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy?	77
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections	76
Loss of ARID1A ‘loops’ in STING	75
Subscription and Copyright Information	72
EmBmem: will the real memory B cell please stand up?	68
Risk factors of cytokine release syndrome: stress, catecholamines, and beyond	65
Oxidative battles in tuberculosis: walking the ferroptotic tightrope	64
DNA at the center of mammalian innate immune recognition of bacterial biofilms	64

BCR signaling in germinal center B cell selection	61
Targeting WSTF degradation to resolve chronic inflammation	60
The tumor niche can reprogram long-lived protumorigenic neutrophils	60
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis	58
Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine	58
Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics	53
Inflammatory and immune etiology of type 2 diabetes	51
Advisory Board and Contents	50
The five senses of immunity	50
Unanticipated specificity in effector-triggered immunity	48
Microglia as integrators of brain-associated molecular patterns	48
Infusion of neutralization into Lassa vaccine design	48
Cytosolic delivery of innate immune agonists	48
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology	47
The translational potential of studying bat immunity	46
Leveraging community engagement to shape biomedical research priorities	46
Genotype–phenotype landscapes for immune–pathogen coevolution	45
Subscription and Copyright Information	44
Tumor microenvironment metabolites directing T cell differentiation and function	44
Agents of cancer immunosurveillance: HSPs and dsDNA	44
Context-dependent regulation of follicular helper T cell survival	43
Maternal inflammation and its ramifications on fetal neurodevelopment	43
High endothelial venules as potential gateways for therapeutics	42
Targeting Th17 cells in HIV-1 remission/cure interventions	41
Subscription and Copyright Information	41
Astrocytes ACLYmate to chronic neuroinflammation	39
Mitochondrial dysfunction in myeloid cells: a central deficit in autoimmune diseases	38
Bridging anatomical gaps between brain and immune system	36
Antigen presentation by MHC-E: a putative target for vaccination?	36
Intracellular C1q – an unexpected player in neuronal proteostasis	36
Balancing IL-17–mediated protection and IFN-γ–driven pathology at mucocutaneous barriers	35
Natural resistance against infections: focus on COVID-19	34
Subscription and Copyright Information	33
Subscription and Copyright Information	33
Original antigenic sin: not so sinful after all	33
Subscription and Copyright Information	33
Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens	33
B cells masquerade as dendritic cells	33
Immune evasion in ovarian cancer: implications for immunotherapy and emerging treatments	32
Immunology as a guide to human relationships	32
Advisory Board and Contents	32
Monoallelic expression in human immune cells: linking genotype to phenotype	32
Calreticulin surface presentation can promote quality control of hematopoietic stem cells	31
Lymphoid tissue on the mind	31
Old macrophages lose their (circadian) rhythm	31
Emerging roles for tRNAs in hematopoiesis and hematological malignancies	30
TLR9 triggers MyD88-independent anti-inflammatory signaling in lupus	30
The complex immunological role of Helicobacter in modulating cancer	29
Subscription and Copyright Information	29
Spiking SARS-CoV-2 antiviral immunity in the respiratory tract	29

LNCing RNA to immunity	29
Transcription factor-driven regulation of ILC1 and ILC3	28
Advisory Board and Contents	28
Exploring mucosal immune development and function in utero	27
Chimeric antigen receptor Treg therapy in transplantation	27
Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities	27
Subscription and Copyright Information	27
Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers	27
Gut microbiota–host post-translational modification axis in immunometabolic diseases	27
Advisory Board and Contents	26
Signaling is the pathway to macrophage function	26
Targeting the metabolism of tumor-infiltrating regulatory T cells	25
Putative role of STING-mitochondria associated membrane crosstalk in immunity	25
Protists protecting food tolerance	25
Advisory Board and Contents	25
Sensory nerves unlock the TOLL-7 gate for cancer spread	25
Advisory Board and Contents	25
Sensory neuronal control of skin barrier immunity	24
Regulation and impact of tumor-specific CD4+ T cells in cancer and immunotherapy	24
Multiple sclerosis: role of meningeal lymphoid aggregates in progression independent of relapse activity	24
Protect, repair, rewire, and defend	24
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy	24
TCR-sequencing in cancer and autoimmunity: barcodes and beyond	24
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New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies	23
Overcoming gender bias in STEM	23
Subscription and Copyright Information	23
Immune-featured decidual stromal cells: pregnancy's multitasking superstars	22
Advisory Board and Contents	22
Harder, better, faster, stronger: biochemistry and biophysics in the immunosurveillance concert	22
Th17 cells: from gut homeostasis to CNS pathogenesis	21
The predictive power of systems immunology	20
How do autoimmune CD4+ T cells handle exhaustion?	20
Immunotherapy response-associated Akkermansia: canary in a coal mine?	20
BCG vaccination induces cross-protective immunity against pathogenic microorganisms	20
Inflammasome diversity: exploring novel frontiers in the innate immune response	19
Partners and guardians of the nervous and immune systems	19
COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle	19
Repurposing of old drugs for unleashing innate immunity	19
Feeding the wrath with myelin	19
SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences	18
B cell phylogenetics in the single cell era	18
RORγt protein modifications and IL-17-mediated inflammation	18
Life and death of tolerogenic dendritic cells	18
CD8+ Tregs kill pathogenic cells to avert autoimmunity	18
Subscription and Copyright Information	18
The diversity of cGLR receptors: shedding new light on innate immunity	18
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases	18
Development of a circadian immune system	17
Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment	17
Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunity	17
Lymph node fibroblast-produced extracellular matrix shapes immune function	17
Early clues regarding the pathogenesis of long-COVID	17
Human neutrophil kinetics: a call to revisit old evidence	16
Finding your niche: immune evasion in quiescent tumor reservoirs	16
The extracellular matrix and immunity: breaking the old barrier in cancer	16
News from the T cell trogocytosis front	16
cGAS-like receptors: back to the future	16
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis	16
Advisory Board and Contents	15
Breaking down IgA: Tomasiella immunophila enlightens microbiome–immune interactions	15
Inflammasomopathies: mechanisms and disease signatures	15
Molecular mimicry as a driver of T cell-mediated tumour immunity	15
Macrophage states: there's a method in the madness	15
Neuro–immune crosstalk: focus on innate lymphoid cells	15
ICOS-play: dressing T cells for residency	15
Restriction factors regulating human herpesvirus infections	14
Turning cold tumors hot: from molecular mechanisms to clinical applications	14
Physiological role of cytokines in the regulation of mammalian metabolism	14
Exhausted CD8+ T cells face a developmental fork in the road	14
Channel plan: control of adaptive immune responses by pannexins	14
RNA circuits and RNA-binding proteins in T cells	14
Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice	14
Unraveling B cell trajectories at single cell resolution	14
Cancer germline antigens and tumor-agnostic CD8+ T cell evasion	13
Zebrafish: an underutilized tool for discovery in host–microbe interactions	13
Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?	13
The T cell subsetting challenge	13
Unleashing TNF cytotoxicity to enhance cancer immunotherapy	13
New insights into transcription elongation control of HIV-1 latency and rebound	13

Baby’s skin bacteria: first impressions are long-lasting	13
The meningeal lymphatics: regulators of Aβ immunotherapy?	13
A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development	13
Advisory Board and Contents	12
Malaria: influence of Anopheles mosquito saliva on Plasmodium infection	12
Enhancing tumor immunity via in vivo cDC1 reprogramming	12
Prenatal inflammation shapes microglial immune response into adulthood	12
Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine	12
Developing cultural humility in immunology and STEMM mentoring	12
T cell TET2 disruption cuts the breaks on antitumor CAR T cell therapy	12
Advisory Board and Contents	12
SARS-CoV-2 vaccination washes away original antigenic sin	12
Cryptic but critical: non-canonical antigens in cancer immunotherapy	11
Microglia replacement: from monocytic origin to therapy	11
Aching to defend: spleen innervation drives humoral immunity	11
Using TCR-CAR dual signaling for precise cancer targeting	11
Approaches for studying neuroimmune interactions in Alzheimer’s disease	11
Affinity-independent plasma cell differentiation in germinal centers	11
Ghrelin and leptin regulating wound healing	11
Advisory Board and Contents	10
Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond	10
Monoclonal antibodies lock down SARS-CoV-2 spike	10
Uniting innate and adaptive immunity in glioblastoma; an α-CTLA-4 quest	10
Host immunity and cellular responses to bacterial outer membrane vesicles	10
Towards a quantitative theory of tolerance	10
Locus architecture and RAG scanning determine antibody diversity	10
Inflammatory and immune effects on tumor progression	10
Regional specialization within the mammalian respiratory immune system	10
Advisory Board and Contents	10
Humans pIKK-up NLRP3 to skip NEK7	10
Subscription and Copyright Information	10
Introducing the 'Significance' box in Trends in Immunology articles	10
Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death	9
Advisory Board and Contents	9
Deciphering SARS-CoV-2 evolution under antibody immune pressure	8
Targeting immune evasion in hepatocellular carcinoma-initiating cells	8
Genetic conflicts and the origin of self/nonself-discrimination in the vertebrate immune system	8
Pseudomonas aeruginosa: a pathogen making itself at home	8
Enlightening Per2-suasive role of neutrophils in antibacterial immunity	8
Microglia pack a toolbox for life	8
Subscription and Copyright Information	8
Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus	8
Multiscale geometric and topological analyses for characterizing and predicting immune responses from single cell data	8
Germinal centre B cell disruption by non-typhoidal Salmonella	8
Gutsy sensations modulate intestinal disease	8
Memory B cell diversity: insights for optimized vaccine design	8
Subscription and Copyright Information	8
Structure-based mechanisms of 2′3′-cGAMP intercellular transport in the cGAS–STING immune pathway	7
Lung tumor immunity: redirecting macrophages through infection-induced inflammation	7
Mutagenic repair during antibody diversification: emerging insights	7
Advisory Board and Contents	7
Embryonic microglia maintain the brain's cortical fault lines	7
ADAR1 and ZBP1 in innate immunity, cell death, and disease	7
Subscription and Copyright Information	7
Decoding microglial functions in Alzheimer’s disease: insights from human models	6
Deconstructing iNKT cell development at single-cell resolution	6
Towards decoding the space-time continuum of pregnancy	6
Modeling human immune responses to vaccination in vitro	6
Why do central nervous system barriers host a diverse immune landscape?	6
The Vibrio cholerae maneuver	6
The putative contribution of cellular senescence to driving tauopathies	6
Boosting peripheral immunity to fight neurodegeneration in the brain	6
Diet and immune response: how today’s plate shapes tomorrow’s health	6
Allogeneic hematopoietic stem cell transplantation: lessons learned by a molecular immunologist/transplant patient	6
Leveraging deep learning to improve vaccine design	6
The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder	6
Transcriptional control of natural killer cell antitumor activity	6
The heightened importance of the microbiome in cancer immunotherapy	6
Helper ILCs in the human hematopoietic system	6
Advisory Board and Contents	6
Tracking tumor-specific CD8+ T cell responses	6
Approaches for studying human macrophages	6
Recombinant snake antivenoms get closer to the clinic	6
Over but not gone: lingering epigenetic effects of COVID-19	6
Immunomodulatory impact of α-fetoprotein	6
NF-κB: blending metabolism, immunity, and inflammation	5
Restraining the killers: regulation of T cell quiescence	5
A mother's touch: microbial guardians of early immune imprinting	5
Subscription and Copyright Information	5
On developmental programming of the immune system	5
The cancer cell-derived extracellular vesicle glycocode in immunoevasion	5
Complement(ing) long-COVID thromboinflammation and pathogenesis	5
Mitochondrial lipid metabolism in tumor immunosurveillance and evasion	5
Nanotube-mediated mitochondrial transfer: power to the T cells!	5
The Janus face of NK cells in neurodevelopment	5
Advisory Board and Contents	5
Base editors dissect genetic variants in human hematopoietic cells on a large scale	5
Lipopolysaccharide delivery systems in innate immunity	5
Macrophage immunotherapy: overcoming impediments to realize promise	5
Beyond antiviral: role of IFN-I in brain development	5
Breaking tolerance: an update of Treg dysfunction in autoimmunity	5
ZBTB46 in ILC3: shared transcriptional infrastructure defines gut-protective capabilities	5
Subscription and Copyright Information	5
One degree of separation: urgent questions surrounding new USA laws in women’s healthcare	5
cGAS-like receptors: ancient catchers of viral nucleic acids	5