Trends in Immunology

Article	Citations
Advisory Board and Contents	439
Advisory Board and Contents	364
Advisory Board and Contents	352
Subscription and Copyright Information	187
DNA flexibility can shape the preferential hypermutation of antibody genes	168
Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?	149
Dietary fibers affecting gastrointestinal immunity	146
Unleashing dendritic cell-mediated tumor clearance by targeting Bcl-2	136
On tending sprouts: empowering emerging immunologists in Latin America	120
Lymph node stromal cells: subsets and functions in health and disease	116
Ragulator-Rag and ROS TORment gasdermin D pore formation	115
Novel insights and recent progress in osteoimmunology	110
Innate immunity: the bacterial connection	93
Contribution of gut-derived T cells to extraintestinal autoimmune diseases	87
Tensor-based insights into systems immunity and infectious disease	83
Metabolic and stress response adaptations in T cells to fever and physiological heat	75
Emerging roles of Dectin-1 in noninfectious settings and in the CNS	73
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EmBmem: will the real memory B cell please stand up?	66
Loss of ARID1A ‘loops’ in STING	66
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections	65
BCR signaling in germinal center B cell selection	65
DNA at the center of mammalian innate immune recognition of bacterial biofilms	64
Risk factors of cytokine release syndrome: stress, catecholamines, and beyond	63
Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics	60

Inflammatory and immune etiology of type 2 diabetes	59
Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy?	57
Targeting WSTF degradation to resolve chronic inflammation	55
The tumor niche can reprogram long-lived protumorigenic neutrophils	53
Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine	53
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis	53
Agents of cancer immunosurveillance: HSPs and dsDNA	52
Oxidative battles in tuberculosis: walking the ferroptotic tightrope	52
Context-dependent regulation of follicular helper T cell survival	50
The five senses of immunity	50
Infusion of neutralization into Lassa vaccine design	48
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Cytosolic delivery of innate immune agonists	45
Leveraging community engagement to shape biomedical research priorities	45
Tumor microenvironment metabolites directing T cell differentiation and function	45
The translational potential of studying bat immunity	44
Targeting Th17 cells in HIV-1 remission/cure interventions	44
Microglia as integrators of brain-associated molecular patterns	43
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology	43
High endothelial venules as potential gateways for therapeutics	43
Maternal inflammation and its ramifications on fetal neurodevelopment	42
Unanticipated specificity in effector-triggered immunity	42
Genotype–phenotype landscapes for immune–pathogen coevolution	41
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Advisory Board and Contents	40
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Subscription and Copyright Information	40
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Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens	39
Natural resistance against infections: focus on COVID-19	38
Astrocytes ACLYmate to chronic neuroinflammation	38
B cells masquerade as dendritic cells	37
Bridging anatomical gaps between brain and immune system	36
Original antigenic sin: not so sinful after all	35
Intracellular C1q – an unexpected player in neuronal proteostasis	34
Immune evasion in ovarian cancer: implications for immunotherapy and emerging treatments	33
Antigen presentation by MHC-E: a putative target for vaccination?	33
Monoallelic expression in human immune cells: linking genotype to phenotype	32
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The complex immunological role of Helicobacter in modulating cancer	31
Spiking SARS-CoV-2 antiviral immunity in the respiratory tract	30
Old macrophages lose their (circadian) rhythm	30
TLR9 triggers MyD88-independent anti-inflammatory signaling in lupus	30
Lymphoid tissue on the mind	30
Emerging roles for tRNAs in hematopoiesis and hematological malignancies	30
Calreticulin surface presentation can promote quality control of hematopoietic stem cells	30
Advisory Board and Contents	29
Transcription factor-driven regulation of ILC1 and ILC3	29
LNCing RNA to immunity	29
Advisory Board and Contents	28

Advisory Board and Contents	28
Signaling is the pathway to macrophage function	27
Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers	27
Gut microbiota–host post-translational modification axis in immunometabolic diseases	27
Protists protecting food tolerance	27
Exploring mucosal immune development and function in utero	26
Putative role of STING-mitochondria associated membrane crosstalk in immunity	26
Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities	26
Chimeric antigen receptor Treg therapy in transplantation	25
Advisory Board and Contents	25
Harder, better, faster, stronger: biochemistry and biophysics in the immunosurveillance concert	25
Advisory Board and Contents	25
Immunotherapy response-associated Akkermansia: canary in a coal mine?	25
New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies	25
Targeting the metabolism of tumor-infiltrating regulatory T cells	25
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Overcoming gender bias in STEM	25
Protect, repair, rewire, and defend	24
The predictive power of systems immunology	24
Immune-featured decidual stromal cells: pregnancy's multitasking superstars	24
Th17 cells: from gut homeostasis to CNS pathogenesis	23
Multiple sclerosis: role of meningeal lymphoid aggregates in progression independent of relapse activity	23
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BCG vaccination induces cross-protective immunity against pathogenic microorganisms	23
TCR-sequencing in cancer and autoimmunity: barcodes and beyond	23
Sensory nerves unlock the TOLL-7 gate for cancer spread	23
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CD8+ Tregs kill pathogenic cells to avert autoimmunity	22
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy	22
Regulation and impact of tumor-specific CD4+ T cells in cancer and immunotherapy	22
Sensory neuronal control of skin barrier immunity	22
Life and death of tolerogenic dendritic cells	22
COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle	21
Feeding the wrath with myelin	21
Partners and guardians of the nervous and immune systems	21
Development of a circadian immune system	20
B cell phylogenetics in the single cell era	20
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases	20
The diversity of cGLR receptors: shedding new light on innate immunity	20
Repurposing of old drugs for unleashing innate immunity	19
SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences	19
RORγt protein modifications and IL-17-mediated inflammation	18
How do autoimmune CD4+ T cells handle exhaustion?	18
Lymph node fibroblast-produced extracellular matrix shapes immune function	18
Finding your niche: immune evasion in quiescent tumor reservoirs	18
Inflammasome diversity: exploring novel frontiers in the innate immune response	18
Why are there so few (or so many) circulating coronaviruses?	17
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis	17
cGAS-like receptors: back to the future	17
The extracellular matrix and immunity: breaking the old barrier in cancer	17
Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment	17
Human neutrophil kinetics: a call to revisit old evidence	17
News from the T cell trogocytosis front	17
Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunity	16
Early clues regarding the pathogenesis of long-COVID	16
ICOS-play: dressing T cells for residency	15
RNA circuits and RNA-binding proteins in T cells	15
Advisory Board and Contents	15
Physiological role of cytokines in the regulation of mammalian metabolism	14
Inflammasomopathies: mechanisms and disease signatures	14
Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice	14
Macrophage states: there's a method in the madness	14
Advisory Board and Contents	14
Breaking down IgA: Tomasiella immunophila enlightens microbiome–immune interactions	14
Restriction factors regulating human herpesvirus infections	14
Neuro–immune crosstalk: focus on innate lymphoid cells	14
Unraveling B cell trajectories at single cell resolution	14
Lipid regulation of NLRP3 inflammasome activity through organelle stress	14
Exhausted CD8+ T cells face a developmental fork in the road	14
Molecular mimicry as a driver of T cell-mediated tumour immunity	14
Turning cold tumors hot: from molecular mechanisms to clinical applications	14
T cell TET2 disruption cuts the breaks on antitumor CAR T cell therapy	13
The meningeal lymphatics: regulators of Aβ immunotherapy?	13
Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?	13
The T cell subsetting challenge	13
Cancer germline antigens and tumor-agnostic CD8+ T cell evasion	13
A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development	13
Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine	12
Zebrafish: an underutilized tool for discovery in host–microbe interactions	12
Monoclonal antibodies lock down SARS-CoV-2 spike	12

Channel plan: control of adaptive immune responses by pannexins	12
Baby’s skin bacteria: first impressions are long-lasting	12
Advisory Board and Contents	12
Prenatal inflammation shapes microglial immune response into adulthood	12
Unleashing TNF cytotoxicity to enhance cancer immunotherapy	12
New insights into transcription elongation control of HIV-1 latency and rebound	12
Advisory Board and Contents	11
Towards a quantitative theory of tolerance	11
Approaches for studying neuroimmune interactions in Alzheimer’s disease	11
Uniting innate and adaptive immunity in glioblastoma; an α-CTLA-4 quest	11
Advisory Board and Contents	11
Enhancing tumor immunity via in vivo cDC1 reprogramming	11
Using TCR-CAR dual signaling for precise cancer targeting	11
Introducing the 'Significance' box in Trends in Immunology articles	11
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Trust your gut: an early life lesson for T cells	11
Affinity-independent plasma cell differentiation in germinal centers	11
Microglia replacement: from monocytic origin to therapy	11
Developing cultural humility in immunology and STEMM mentoring	10
Ghrelin and leptin regulating wound healing	10
Aching to defend: spleen innervation drives humoral immunity	10
Cryptic but critical: non-canonical antigens in cancer immunotherapy	10
Malaria: influence of Anopheles mosquito saliva on Plasmodium infection	10
Locus architecture and RAG scanning determine antibody diversity	10
Regional specialization within the mammalian respiratory immune system	10
SARS-CoV-2 vaccination washes away original antigenic sin	10
Inflammatory and immune effects on tumor progression	10
Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond	9
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Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus	9
Microglia pack a toolbox for life	9
Host immunity and cellular responses to bacterial outer membrane vesicles	9
Advisory Board and Contents	9
Gutsy sensations modulate intestinal disease	9
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Humans pIKK-up NLRP3 to skip NEK7	9
Genetic conflicts and the origin of self/nonself-discrimination in the vertebrate immune system	9
Deciphering SARS-CoV-2 evolution under antibody immune pressure	9
Targeting immune evasion in hepatocellular carcinoma-initiating cells	8
Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death	8
Enlightening Per2-suasive role of neutrophils in antibacterial immunity	8
Mutagenic repair during antibody diversification: emerging insights	8
Multiscale geometric and topological analyses for characterizing and predicting immune responses from single cell data	8
Structure-based mechanisms of 2′3′-cGAMP intercellular transport in the cGAS–STING immune pathway	8
Memory B cell diversity: insights for optimized vaccine design	8
ADAR1 and ZBP1 in innate immunity, cell death, and disease	8
Pseudomonas aeruginosa: a pathogen making itself at home	8
Advisory Board and Contents	7
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The Vibrio cholerae maneuver	7
Embryonic microglia maintain the brain's cortical fault lines	7
Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks	7
Tracking tumor-specific CD8+ T cell responses	6
The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder	6
Over but not gone: lingering epigenetic effects of COVID-19	6
Recombinant snake antivenoms get closer to the clinic	6
Advisory Board and Contents	6
Oxidative stress, malaria, sickle cell disease, and innate immunity	6
Helper ILCs in the human hematopoietic system	6
C3-targeted therapy in periodontal disease: moving closer to the clinic	6
Allogeneic hematopoietic stem cell transplantation: lessons learned by a molecular immunologist/transplant patient	6
Towards decoding the space-time continuum of pregnancy	6
Immunomodulatory impact of α-fetoprotein	6
Lung tumor immunity: redirecting macrophages through infection-induced inflammation	6
The putative contribution of cellular senescence to driving tauopathies	6
Tissue-specific differentiation of CD8+ resident memory T cells	5
The heightened importance of the microbiome in cancer immunotherapy	5
Diet and immune response: how today’s plate shapes tomorrow’s health	5
Macrophage immunotherapy: overcoming impediments to realize promise	5
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Leveraging human immune organoids for rational vaccine design	5
Approaches for studying human macrophages	5
Deconstructing iNKT cell development at single-cell resolution	5
Complement(ing) long-COVID thromboinflammation and pathogenesis	5
Leveraging deep learning to improve vaccine design	5
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Why do central nervous system barriers host a diverse immune landscape?	5
Modeling human immune responses to vaccination in vitro	5
Decoding microglial functions in Alzheimer’s disease: insights from human models	5
Boosting peripheral immunity to fight neurodegeneration in the brain	5
NF-κB: blending metabolism, immunity, and inflammation	5
Advisory Board and Contents	5
Advisory Board and Contents	5
Keeping T cell memories in mind	4
Emerging roles of astrocytes as immune effectors in the central nervous system	4
Single B cell technologies for monoclonal antibody discovery	4
Mutant ARID1A: igniting cancer immunotherapy	4
Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis	4
The unusual metabolism of germinal center B cells	4
Splicing dysregulation in human hematologic malignancies: beyond splicing mutations	4
Sterols in asthma	4
The extracellular matrix in solid tumor immunotherapy	4
Mitochondria and lysosomes in T cell immunometabolism	4
DNA repair and antibody diversification: the 53BP1 paradigm	4
Liquid–liquid phase separation in innate immunity	4