Trends in Immunology

Article	Citations
Subscription and Copyright Information	587
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Experimental immunologists in the era of artificial intelligence	454
DNA flexibility can shape the preferential hypermutation of antibody genes	276
Advisory Board and Contents	235
Metabolic and stress response adaptations in T cells to fever and physiological heat	191
Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?	125
Advisory Board and Contents	122
Advisory Board and Contents	115
On tending sprouts: empowering emerging immunologists in Latin America	103
Dietary fibers affecting gastrointestinal immunity	95
Unleashing dendritic cell-mediated tumor clearance by targeting Bcl-2	91
Novel insights and recent progress in osteoimmunology	88
Two models, one question: how does respiratory syncytial virus cause asthma?	83
Innate immunity: the bacterial connection	81
Contribution of gut-derived T cells to extraintestinal autoimmune diseases	77
Tensor-based insights into systems immunity and infectious disease	76
‘Smelling’ lipid cues: chemosensory receptors tune tumor-associated macrophage behavior	75
Loss of ARID1A ‘loops’ in STING	74
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EmBmem: will the real memory B cell please stand up?	67
Targeting WSTF degradation to resolve chronic inflammation	65
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections	61
Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine	55
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis	54

Oxidative battles in tuberculosis: walking the ferroptotic tightrope	54
DNA at the center of mammalian innate immune recognition of bacterial biofilms	54
Inflammatory and immune etiology of type 2 diabetes	53
KLHL6: a proteostatic guardian against T-cell exhaustion	50
Beyond the innate immune system: rethinking inflammasomes in multiple sclerosis	49
Risk factors of cytokine release syndrome: stress, catecholamines, and beyond	48
The tumor niche can reprogram long-lived protumorigenic neutrophils	47
Advisory Board and Contents	47
BCR signaling in germinal center B cell selection	47
Agents of cancer immunosurveillance: HSPs and dsDNA	47
Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics	47
Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy?	47
Genotype–phenotype landscapes for immune–pathogen coevolution	46
Leveraging community engagement to shape biomedical research priorities	45
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High endothelial venules as potential gateways for therapeutics	41
Microglia in systemic neuroimmune communication: functions beyond phagocytosis	41
The five senses of immunity	41
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology	41
Infusion of neutralization into Lassa vaccine design	40
The translational potential of studying bat immunity	39
Microglia as integrators of brain-associated molecular patterns	39
Secondary bile acids as immune and metabolic mediators	39
Unanticipated specificity in effector-triggered immunity	39
Cytokine specificity in macrophages: JAK-STAT and beyond	39
Cytosolic delivery of innate immune agonists	38
Targeting Th17 cells in HIV-1 remission/cure interventions	38
Advisory Board and Contents	38
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Original antigenic sin: not so sinful after all	37
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B cells masquerade as dendritic cells	36
Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens	35
Immunology as a guide to human relationships	34
Intracellular C1q – an unexpected player in neuronal proteostasis	33
Astrocytes ACLYmate to chronic neuroinflammation	33
Interleukin-22: the hub bridging gut homeostasis and metabolism	32
Bridging anatomical gaps between brain and immune system	32
Antigen presentation by MHC-E: a putative target for vaccination?	32
Balancing IL-17–mediated protection and IFN-γ–driven pathology at mucocutaneous barriers	32
Mitochondrial dysfunction in myeloid cells: a central deficit in autoimmune diseases	31
Calreticulin surface presentation can promote quality control of hematopoietic stem cells	31
Immune evasion in ovarian cancer: implications for immunotherapy and emerging treatments	31
TLR9 triggers MyD88-independent anti-inflammatory signaling in lupus	31
Spiking SARS-CoV-2 antiviral immunity in the respiratory tract	31
The complex immunological role of Helicobacter in modulating cancer	30
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Immunoferroptosis: ferroptosis meets tumor immunity and immunotherapy	30

Seven subsets, two fates: mouse γδ T cells in cancer immunity	30
Lymphoid tissue on the mind	29
Emerging roles for tRNAs in hematopoiesis and hematological malignancies	29
Targeting γδ T cells for immunotherapies against colorectal cancer	29
Transcription factor-driven regulation of ILC1 and ILC3	28
Protists protecting food tolerance	28
LNCing RNA to immunity	28
Advisory Board and Contents	28
Monoallelic expression in human immune cells: linking genotype to phenotype	28
Subscription and Copyright Information	27
Advisory Board and Contents	27
Advisory Board and Contents	27
Signaling is the pathway to macrophage function	26
The lingering shadow of epidemics: post-acute sequelae across history	26
Chimeric antigen receptor Treg therapy in transplantation	26
Gut microbiota–host post-translational modification axis in immunometabolic diseases	26
Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers	26
Targeting the metabolism of tumor-infiltrating regulatory T cells	26
Exploring mucosal immune development and function in utero	26
Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities	26
Putative role of STING-mitochondria associated membrane crosstalk in immunity	26
Advisory Board and Contents	25
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Protect, repair, rewire, and defend	24
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The predictive power of systems immunology	23
Redefining nucleotide-binding oligomerization domain-like receptors: from immune sentinels to multifunctional regulators	23
Advisory Board and Contents	23
Advisory Board and Contents	23
Lactation, tissue-resident immunity, and protection against breast cancer	22
Immune-featured decidual stromal cells: pregnancy's multitasking superstars	22
Immunotherapy response-associated Akkermansia: canary in a coal mine?	22
Regulation and impact of tumor-specific CD4+ T cells in cancer and immunotherapy	21
Overcoming gender bias in STEM	21
Multiple sclerosis: role of meningeal lymphoid aggregates in progression independent of relapse activity	21
Sensory nerves unlock the TOLL-7 gate for cancer spread	21
New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies	21
Repurposing of old drugs for unleashing innate immunity	20
Sensory neuronal control of skin barrier immunity	20
Feeding the wrath with myelin	20
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy	20
COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle	20
SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences	19
CD8+ Tregs kill pathogenic cells to avert autoimmunity	19
Microbes, molecules, and the maternal–fetal interface: rethinking the gut–placenta axis	19
The diversity of cGLR receptors: shedding new light on innate immunity	19
Inflammasome diversity: exploring novel frontiers in the innate immune response	19
Development of a circadian immune system	19
Lymph node fibroblast-produced extracellular matrix shapes immune function	19
How do autoimmune CD4+ T cells handle exhaustion?	18
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The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases	18
B cell phylogenetics in the single cell era	17
Dancing immunity	17
Partners and guardians of the nervous and immune systems	17
The extracellular matrix and immunity: breaking the old barrier in cancer	16
Advisory Board and Contents	16
Life and death of tolerogenic dendritic cells	16
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis	16
Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment	16
Finding your niche: immune evasion in quiescent tumor reservoirs	16
Molecular mechanisms of type 2 innate immune sensing	16
Human neutrophil kinetics: a call to revisit old evidence	15
Post-translational modifications of NLRP3: to prime or not to prime?	15
News from the T cell trogocytosis front	15
cGAS-like receptors: back to the future	15
Local cues, local killers: human natural killer cells across tissues	15
Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunity	15
Neuro–immune crosstalk: focus on innate lymphoid cells	14
RNA circuits and RNA-binding proteins in T cells	14
Advisory Board and Contents	14
Molecular mimicry as a driver of T cell-mediated tumour immunity	14
Breaking down IgA: Tomasiella immunophila enlightens microbiome–immune interactions	14
Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice	13
Macrophage states: there's a method in the madness	13
Turning cold tumors hot: from molecular mechanisms to clinical applications	13
Restriction factors regulating human herpesvirus infections	13
Exhausted CD8+ T cells face a developmental fork in the road	13
Physiological role of cytokines in the regulation of mammalian metabolism	13
Revisiting the macrophage disappearance reaction	13

Inflammasomopathies: mechanisms and disease signatures	13
Cancer germline antigens and tumor-agnostic CD8+ T cell evasion	13
Advisory Board and Contents	12
Zebrafish: an underutilized tool for discovery in host–microbe interactions	12
T cell TET2 disruption cuts the breaks on antitumor CAR T cell therapy	12
Advisory Board and Contents	12
Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?	12
Prenatal inflammation shapes microglial immune response into adulthood	12
Channel plan: control of adaptive immune responses by pannexins	11
The T cell subsetting challenge	11
New insights into transcription elongation control of HIV-1 latency and rebound	11
Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine	11
Advisory Board and Contents	11
A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development	11
IEL–IEC circuit in barrier immunity and beyond	11
Advisory Board and Contents	10
Monoclonal antibodies lock down SARS-CoV-2 spike	10
Aching to defend: spleen innervation drives humoral immunity	10
Advisory Board and Contents	10
Ghrelin and leptin regulating wound healing	10
Introducing the 'Significance' box in Trends in Immunology articles	10
Uniting innate and adaptive immunity in glioblastoma; an α-CTLA-4 quest	10
Subscription and Copyright Information	10
Regional specialization within the mammalian respiratory immune system	10
Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond	9
Enhancing tumor immunity via in vivo cDC1 reprogramming	9
Cell intrinsic versus cell extrinsic control of plasma cell longevity	9
Humans pIKK-up NLRP3 to skip NEK7	9
Cryptic but critical: non-canonical antigens in cancer immunotherapy	9
Towards a quantitative theory of tolerance	9
Malaria: influence of Anopheles mosquito saliva on Plasmodium infection	9
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Affinity-independent plasma cell differentiation in germinal centers	8
Targeting TLR2 agonists as immunomodulators with broad antiviral activity	8
Enlightening Per2-suasive role of neutrophils in antibacterial immunity	8
Locus architecture and RAG scanning determine antibody diversity	8
Microglia replacement: from monocytic origin to therapy	8
Gutsy sensations modulate intestinal disease	8
Advisory Board and Contents	8
Using TCR-CAR dual signaling for precise cancer targeting	8
Approaches for studying neuroimmune interactions in Alzheimer’s disease	8
Targeting immune evasion in hepatocellular carcinoma-initiating cells	7
Multiscale geometric and topological analyses for characterizing and predicting immune responses from single cell data	7
Deciphering SARS-CoV-2 evolution under antibody immune pressure	7
Mutagenic repair during antibody diversification: emerging insights	7
Germinal centre B cell disruption by non-typhoidal Salmonella	7
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Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death	7
Maternal diet shapes the development and identity of tissue-resident macrophages	7
Microglia pack a toolbox for life	7
Pseudomonas aeruginosa: a pathogen making itself at home	7
Advisory Board and Contents	7
Memory B cell diversity: insights for optimized vaccine design	7
Structure-based mechanisms of 2′3′-cGAMP intercellular transport in the cGAS–STING immune pathway	7
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Embryonic microglia maintain the brain's cortical fault lines	7
Genetic conflicts and the origin of self/nonself-discrimination in the vertebrate immune system	7
ADAR1 and ZBP1 in innate immunity, cell death, and disease	7
The putative contribution of cellular senescence to driving tauopathies	6
Towards decoding the space-time continuum of pregnancy	6
Tracking tumor-specific CD8+ T cell responses	6
The Vibrio cholerae maneuver	6
Transcriptional control of natural killer cell antitumor activity	6
Get with the program: regulation of T cell death	6
Helper ILCs in the human hematopoietic system	6
Advisory Board and Contents	6
The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder	6
Over but not gone: lingering epigenetic effects of COVID-19	6
Immunomodulatory impact of α-fetoprotein	6
Neuronal inflammasomes: balancing immunity, neuroinflammation, and homeostasis	6
Recombinant snake antivenoms get closer to the clinic	6
Allogeneic hematopoietic stem cell transplantation: lessons learned by a molecular immunologist/transplant patient	6
Lung tumor immunity: redirecting macrophages through infection-induced inflammation	6
Got milk? how T cells shape lactation and beyond	6
Diet and immune response: how today’s plate shapes tomorrow’s health	5
Decoding microglial functions in Alzheimer’s disease: insights from human models	5
Why do central nervous system barriers host a diverse immune landscape?	5
Approaches for studying human macrophages	5
The Janus face of NK cells in neurodevelopment	5
Modeling human immune responses to vaccination in vitro	5
Deconstructing iNKT cell development at single-cell resolution	5
Endothelial cells modulate immune cell responses during atherosclerosis	5
A mother's touch: microbial guardians of early immune imprinting	5
Boosting peripheral immunity to fight neurodegeneration in the brain	5
Cholesterol sensing and metabolic adaptation in tissue immunity	5
Leveraging deep learning to improve vaccine design	5
The heightened importance of the microbiome in cancer immunotherapy	5
Epigenetically programmed identity crisis to combat diffuse large B cell lymphoma	5
Macrophage immunotherapy: overcoming impediments to realize promise	5
NF-κB: blending metabolism, immunity, and inflammation	5
Complement(ing) long-COVID thromboinflammation and pathogenesis	5
Breaking tolerance: an update of Treg dysfunction in autoimmunity	4
The extracellular matrix in solid tumor immunotherapy	4
Lipopolysaccharide delivery systems in innate immunity	4
Mitochondrial lipid metabolism in tumor immunosurveillance and evasion	4