Trends in Immunology

Article	Citations
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis	769
Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses	602
Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity	348
The Role of Astrocytes in CNS Inflammation	265
A Potential Role of Interleukin 10 in COVID-19 Pathogenesis	218
Organoid Models of Tumor Immunology	210
Inflammation and Skeletal Muscle Regeneration: Leave It to the Macrophages!	198
Turning cold tumors hot: from molecular mechanisms to clinical applications	179
Macrophage diversity in cancer revisited in the era of single-cell omics	159
The ‘cytokine storm’: molecular mechanisms and therapeutic prospects	155
Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines	149
Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?	145
Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses	145
T Cells: Warriors of SARS-CoV-2 Infection	136
The Contribution of Epigenetics to Cancer Immunotherapy	136
NF-κB: blending metabolism, immunity, and inflammation	128
CRAC Channels and Calcium Signaling in T Cell-Mediated Immunity	118
To Kill a Microglia: A Case for CSF1R Inhibitors	117
Sialoglycans and Siglecs Can Shape the Tumor Immune Microenvironment	115
Tolerogenic Dendritic Cells in Autoimmunity and Inflammatory Diseases	113
Neuroimmune Connections in Aging and Neurodegenerative Diseases	109
Tissue-Specific Features of Innate Lymphoid Cells	104
Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?	93
VISTA: A Mediator of Quiescence and a Promising Target in Cancer Immunotherapy	90
AID in Antibody Diversification: There and Back Again	89

Cytokine-skewed Tfh cells: functional consequences for B cell help	88
Dual Nature of Type I Interferons in SARS-CoV-2-Induced Inflammation	83
Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)	83
Early clues regarding the pathogenesis of long-COVID	79
Unraveling B cell trajectories at single cell resolution	78
Opportunities for Small Molecules in Cancer Immunotherapy	78
Structural Basis of SARS-CoV-2 and SARS-CoV Antibody Interactions	77
Tissue-resident macrophages: guardians of organ homeostasis	76
How Neutrophils Meet Their End	76
Immune imprinting and SARS-CoV-2 vaccine design	74
A20 and Cell Death-driven Inflammation	69
Decoding the Heterogeneity of Human Dendritic Cell Subsets	68
Polyamines and Kynurenines at the Intersection of Immune Modulation	68
Transcription Factor Bhlhe40 in Immunity and Autoimmunity	66
Monocyte Regulation in Homeostasis and Malignancy	64
Single B cell technologies for monoclonal antibody discovery	64
CD4+ T cells that help B cells – a proposal for uniform nomenclature	63
Predicting and Preventing Immune Checkpoint Inhibitor Toxicity: Targeting Cytokines	61
The Role of TGFβ Signaling in Microglia Maturation and Activation	60
RORγt protein modifications and IL-17-mediated inflammation	60
Sarcoidosis and the mTOR, Rac1, and Autophagy Triad	56
The Speckled Protein (SP) Family: Immunity’s Chromatin Readers	54
Emerging mechanisms of immunocoagulation in sepsis and septic shock	52
Immunotherapeutic Potential of TGF-β Inhibition and Oncolytic Viruses	51
The cholesterol pathway: impact on immunity and cancer	51
Teaching Old Dogs New Tricks? The Plasticity of Lung Alveolar Macrophage Subsets	51
Cardiac Mast Cells: Underappreciated Immune Cells in Cardiovascular Homeostasis and Disease	49
Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment	49
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy	48
Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions	48
Circadian Influences of Diet on the Microbiome and Immunity	48
Sodium and its manifold impact on our immune system	47
Rewriting History: Epigenetic Reprogramming of CD8+ T Cell Differentiation to Enhance Immunotherapy	43
Combining Antivirals and Immunomodulators to Fight COVID-19	43
Activation and Suppression of Group 3 Innate Lymphoid Cells in the Gut	43
LFA-1 in T cell priming, differentiation, and effector functions	43
The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics	43
Context-Dependent Glioblastoma–Macrophage/Microglia Symbiosis and Associated Mechanisms	42
Diversity and Function of Glial Cell Types in Multiple Sclerosis	42
Helper-like Innate Lymphoid Cells in Humans and Mice	40
Type IIA Secreted Phospholipase A2 in Host Defense against Bacterial Infections	40
Overcoming Immune Checkpoint Blockade Resistance via EZH2 Inhibition	40
Differential roles of interferons in innate responses to mucosal viral infections	39
Lymph node fibroblastic reticular cells steer immune responses	37
Complement Factors in COVID-19 Therapeutics and Vaccines	37
New insights into TCR β-selection	36
Investigating Microglia in Health and Disease: Challenges and Opportunities	35
Immunological Features of Non-neuronal Brain Cells: Implications for Alzheimer’s Disease Immunotherapy	35
Host immunity and cellular responses to bacterial outer membrane vesicles	34
Maternal inflammation and its ramifications on fetal neurodevelopment	34

NF-κB and Extrinsic Cell Death Pathways – Entwined Do-or-Die Decisions for T cells	33
SARS Coronavirus Redux	33
K63 ubiquitination in immune signaling	33
The tetraspan MS4A family in homeostasis, immunity, and disease	32
Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks	32
Tissue-specific differentiation of CD8+ resident memory T cells	31
Decoding the dynamics of multilayered stochastic antiviral IFN-I responses	30
Succinate Receptor 1: An Emerging Regulator of Myeloid Cell Function in Inflammation	30
Cell Cycle Regulation Meets Tumor Immunosuppression	30
Unleashing TNF cytotoxicity to enhance cancer immunotherapy	30
Metabolic regulation of the cancer-immunity cycle	29
OTULIN in NF-κB signaling, cell death, and disease	28
NAD+ in COVID-19 and viral infections	28
Neuroimmune cleanup crews in brain injury	28
Enemy or ally? Fasting as an essential regulator of immune responses	28
NLRP3 inflammasomes that induce antitumor immunity	27
Remnant Epitopes Generating Autoimmunity: From Model to Useful Paradigm	27
miRNA-Based Therapies in B Cell Non-Hodgkin Lymphoma	27
C3-targeted therapy in periodontal disease: moving closer to the clinic	27
Systemic Immunoregulatory Consequences of Gut Commensal Translocation	26
Guillain-Barré syndrome: expanding the concept of molecular mimicry	25
Developing pan-β-coronavirus vaccines against emerging SARS-CoV-2 variants of concern	25
Early Events Triggering the Initiation of a Type 2 Immune Response	25
Hematopoiesis in numbers	25
‘Rinse and Replace’: Boosting T Cell Turnover To Reduce HIV-1 Reservoirs	24
Understanding mast cell heterogeneity at single cell resolution	24
T Cell Development: Old Tales Retold By Single-Cell RNA Sequencing	24
Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice	23
Lighting up the tumor fire with low-dose irradiation	23
Emerging roles of Dectin-1 in noninfectious settings and in the CNS	22
Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers	22
ATM: Translating the DNA Damage Response to Adaptive Immunity	21
The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder	21
Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunity	21
BCG vaccination induces cross-protective immunity against pathogenic microorganisms	21
Transcriptional Control of Mature B Cell Fates	21
Lipid regulation of NLRP3 inflammasome activity through organelle stress	20
The Paradoxical Roles of Inflammation during PD-1 Blockade in Cancer	20
The NLRP3 inflammasome: regulation by metabolic signals	20
TCR-sequencing in cancer and autoimmunity: barcodes and beyond	19
Macrophage immunotherapy: overcoming impediments to realize promise	19
Modeling Potential Autophagy Pathways in COVID-19 and Sarcoidosis	19
How metabolism bridles cytotoxic CD8+ T cells through epigenetic modifications	19
The heightened importance of the microbiome in cancer immunotherapy	19
ADAR1 and ZBP1 in innate immunity, cell death, and disease	19
Tick host immunity: vector immunomodulation and acquired tick resistance	19
Lymph node stromal cells: subsets and functions in health and disease	18
Parkinson's disease: connecting mitochondria to inflammasomes	18
Natural resistance against infections: focus on COVID-19	17
Noncanonical Functions of Antibodies	17
Tumor microenvironment metabolites directing T cell differentiation and function	17
Breadth of Antibody Responses during Influenza Virus Infection and Vaccination	17
Genes, Environments, and Phenotypic Plasticity in Immunology	17
NF-κB dynamics in the language of immune cells	17
SARS-CoV-2 vaccination washes away original antigenic sin	16
Synovial macrophages: from ordinary eaters to extraordinary multitaskers	16
Programming cytomegalovirus as an HIV vaccine	16
Developing cultural humility in immunology and STEMM mentoring	16
Noradrenergic Signaling and Neuroinflammation Crosstalk Regulate Toxoplasma gondii-Induced Behavioral Changes	16
Testicular macrophages: development and function in health and disease	16
Protein Arginine Methyltransferase 5 in T Lymphocyte Biology	16
Type 1 conventional dendritic cells: ontogeny, function, and emerging roles in cancer immunotherapy	16
Cell-intrinsic view of the aryl hydrocarbon receptor in tumor immunity	16
Targeting butyrophilins for cancer immunotherapy	16
It Takes Three Receptors to Raise a B Cell	15
The evolutionary and functional significance of germline immunoglobulin gene variation	15
Metabolites and secretory immunoglobulins: messengers and effectors of the host–microbiota intestinal equilibrium	15
Taking T-Cell Oncotherapy Off-the-Shelf	15
Deubiquitinases: Pro-oncogenic Activity and Therapeutic Targeting in Blood Malignancies	15
Baby’s skin bacteria: first impressions are long-lasting	15
Targeting Skin-Resident Memory T Cells via Vaccination to Combat Staphylococcus aureus Infections	15
Deconstructing iNKT cell development at single-cell resolution	14
Conditioning of the immune system by the microbiome	14
The cancer cell-derived extracellular vesicle glycocode in immunoevasion	14
Effect of Low-Pathogenic Human Coronavirus-Specific Antibodies on SARS-CoV-2	14
Transcription factor-driven regulation of ILC1 and ILC3	14
Next-Generation Neuroimmunology: New Technologies to Understand Central Nervous System Autoimmunity	14
Innate antiviral immunity: how prior exposures can guide future responses	14
Zebrafish: an underutilized tool for discovery in host–microbe interactions	14
Interrogating immune cells and cancer with CRISPR-Cas9	13

Cell death checkpoints in the TNF pathway	13
A Synchronous IRF4-Dependent Gene Regulatory Network in B and Helper T Cells Orchestrating the Antibody Response	13
The Roles of T cells in Bladder Pathologies	13
Thymic mimetic cells: tolerogenic masqueraders	13
Immunomodulatory impact of α-fetoprotein	13
The evolution of powerful yet perilous immune systems	12
Type 2 immunity: a two-edged sword in schistosomiasis immunopathology	12
Friendly fungi: symbiosis with commensal Candida albicans	12
Metabolism and epigenetics at the heart of T cell function	12
LNCing RNA to immunity	12
All is not lost: learning from 9p21 loss in cancer	12
Multiple sclerosis: role of meningeal lymphoid aggregates in progression independent of relapse activity	12
An ordeal that does not heal: understanding barriers to a cure for HIV-1 infection	12
Antigen presentation by MHC-E: a putative target for vaccination?	12
On the Improper Use of the Term High-Density Neutrophils	12
Memory B cell diversity: insights for optimized vaccine design	12
Genetic and hormonal mechanisms underlying sex-specific immune responses in tuberculosis	11
Targeting Th17 cells in HIV-1 remission/cure interventions	11
The Role of CD8 Downregulation during Thymocyte Differentiation	11
Does Cross-neutralization of SARS-CoV-2 Only Relate to High Pathogenic Coronaviruses?	11
Microglia and Astrocyte Crosstalk in Immunity	11
Putative role of STING-mitochondria associated membrane crosstalk in immunity	11
Oxidized mitochondrial DNA: a protective signal gone awry	11
New insights into transcription elongation control of HIV-1 latency and rebound	11
Clash of the titans: interferons and SARS-CoV-2	11
Regional specialization of macrophages along the gastrointestinal tract	11
Obesity and dysregulated innate immune responses: impact of micronutrient deficiencies	10
miRNA effects on gut homeostasis: therapeutic implications for inflammatory bowel disease	10
Insights into how SARS-CoV2 infection induces cytokine storms	10
Carbohydrates in allergy: from disease to novel immunotherapies	10
Zebrafish Models to Study Inflammasome-Mediated Regulation of Hematopoiesis	10
Lymph node lymphatic endothelial cells as multifaceted gatekeepers in the immune system	10
AID in Antibody Diversification: There and Back Again	10
Shaped by the epithelium – postnatal immune mechanisms of oral homeostasis	10
Short open reading frame genes in innate immunity: from discovery to characterization	9
High endothelial venules as potential gateways for therapeutics	9
Illuminating Epigenetics and Inheritance in the Immune System with Bioluminescence	9
Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond	9
Human neutrophil kinetics: a call to revisit old evidence	9
Physiological role of cytokines in the regulation of mammalian metabolism	9
Context-dependent regulation of follicular helper T cell survival	9
Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases	8
Harnessing prostaglandin E2 signaling to ameliorate autoimmunity	8
Ragulator-Rag and ROS TORment gasdermin D pore formation	8
Making human immune systems more interpretable through systems immunology	8
Lysozyme: A Double-Edged Sword in the Intestine	8
Targeting the metabolism of tumor-infiltrating regulatory T cells	8
Malaria: influence of Anopheles mosquito saliva on Plasmodium infection	7
Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?	7
Splicing dysregulation in human hematologic malignancies: beyond splicing mutations	7
How can polyreactive antibodies conquer rapidly evolving viruses?	7
The extracellular matrix and immunity: breaking the old barrier in cancer	7
An immune window of opportunity to prevent childhood B cell leukemia	7
Gata6+ large peritoneal macrophages: an evolutionarily conserved sentinel and effector system for infection and injury	7
Neuro–epithelial–ILC2 crosstalk in barrier tissues	7
Using Serology with Models to Clarify the Trajectory of the SARS-CoV-2 Emerging Outbreak	7
Putative regulation of macrophage-mediated inflammation by catestatin	7
Towards systems immunology of critical illness at scale: from single cell ‘omics to digital twins	7
Examining the cooperativity mode of antibody and CD8+ T cell immune responses for vaccinology	7
Staggered starts in the race to T cell activation	7
Inflammatory and immune etiology of type 2 diabetes	7
The impact of age-related hypomethylated DNA on immune signaling upon cellular demise	7
Fate-mapping mice: new tools and technology for immune discovery	7
Fostering experimental and computational synergy to modulate hyperinflammation	7
Redefining Memory T Cell Subsets	7
Exhausted CD8+ T cells face a developmental fork in the road	7
Agents of cancer immunosurveillance: HSPs and dsDNA	7
Gland Macrophages: Reciprocal Control and Function within Their Niche	7
Life and death of tolerogenic dendritic cells	7
Secreted immune metabolites that mediate immune cell communication and function	6
Cancer germline antigens and tumor-agnostic CD8+ T cell evasion	6
Why are there so few (or so many) circulating coronaviruses?	6
What’s the deal with efferocytosis and asthma?	6
Human milk oligosaccharides: potential therapeutic aids for allergic diseases	6
Primary cilia and their effects on immune cell functions and metabolism: a model	6
RNA decay machinery safeguards immune cell development and immunological responses	6
Effector-triggered immunity in mammalian antiviral defense	6
Impact of human CD95 mutations on cell death and autoimmunity: a model	6
The meningeal lymphatics: regulators of Aβ immunotherapy?	5
Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis	5
Archetypes of checkpoint-responsive immunity	5
Flipping the Switch from Inflammation to Cell Death	5
Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications	5
Equity, diversity, and inclusion in academia: lessons from the Canadian Society of Immunology	5
Emerging roles for tRNAs in hematopoiesis and hematological malignancies	5
Linking nutrient sensing, mitochondrial function, and PRR immune cell signaling in liver disease	5
Rationalizing Random Walks: Replicating Protective Antibody Trajectories	5
A new perspective on mesenchymal–immune interactions in adipose tissue	5
‘(m6)A’ stands for ‘autoimmunity’: reading, writing, and erasing RNA modifications during inflammation	5
Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons	5
Towards regulatory cellular therapies in solid organ transplantation	5
Th17 cells: from gut homeostasis to CNS pathogenesis	5
Harder, better, faster, stronger: biochemistry and biophysics in the immunosurveillance concert	4
Where There’s Smoke, There’s Fire: Inflammation Drives MDS	4
Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus	4