Trends in Immunology

Article	Citations
Advisory Board and Contents	363
Metabolic and stress response adaptations in T cells to fever and physiological heat	318
Novel insights and recent progress in osteoimmunology	296
Advisory Board and Contents	267
Advisory Board and Contents	150
Innate immunity: the bacterial connection	144
Subscription and Copyright Information	141
Tonsil organoids: peering down the throat of human immunity	131
DNA flexibility can shape the preferential hypermutation of antibody genes	117
Contribution of gut-derived T cells to extraintestinal autoimmune diseases	115
Unleashing dendritic cell-mediated tumor clearance by targeting Bcl-2	114
Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?	109
On tending sprouts: empowering emerging immunologists in Latin America	101
Lymph node stromal cells: subsets and functions in health and disease	89
Tensor-based insights into systems immunity and infectious disease	88
Ragulator-Rag and ROS TORment gasdermin D pore formation	84
Dietary fibers affecting gastrointestinal immunity	81
Emerging roles of Dectin-1 in noninfectious settings and in the CNS	76
DNA at the center of mammalian innate immune recognition of bacterial biofilms	71
Carbohydrates in allergy: from disease to novel immunotherapies	70
Subscription and Copyright Information	70
Inflammatory and immune etiology of type 2 diabetes	65
Loss of ARID1A ‘loops’ in STING	64
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections	64
EmBmem: will the real memory B cell please stand up?	62

The tumor niche can reprogram long-lived protumorigenic neutrophils	62
Risk factors of cytokine release syndrome: stress, catecholamines, and beyond	58
Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics	57
Oxidative battles in tuberculosis: walking the ferroptotic tightrope	57
BCR signaling in germinal center B cell selection	55
Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine	54
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis	53
High endothelial venules as potential gateways for therapeutics	51
Targeting Th17 cells in HIV-1 remission/cure interventions	50
Unanticipated specificity in effector-triggered immunity	48
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology	48
Agents of cancer immunosurveillance: HSPs and dsDNA	47
The five senses of immunity	46
Genotype–phenotype landscapes for immune–pathogen coevolution	46
Maternal inflammation and its ramifications on fetal neurodevelopment	45
Subscription and Copyright Information	45
Context-dependent regulation of follicular helper T cell survival	44
Leveraging community engagement to shape biomedical research priorities	43
The translational potential of studying bat immunity	43
Tumor microenvironment metabolites directing T cell differentiation and function	43
Original antigenic sin: not so sinful after all	41
Microglia as integrators of brain-associated molecular patterns	41
Advisory Board and Contents	41
Cytosolic delivery of innate immune agonists	41
Subscription and Copyright Information	40
Subscription and Copyright Information	40
B cells masquerade as dendritic cells	39
Subscription and Copyright Information	39
Subscription and Copyright Information	39
Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens	38
Antigen presentation by MHC-E: a putative target for vaccination?	37
Bridging anatomical gaps between brain and immune system	37
Natural resistance against infections: focus on COVID-19	37
Astrocytes ACLYmate to chronic neuroinflammation	37
Immune evasion in ovarian cancer: implications for immunotherapy and emerging treatments	37
Intracellular C1q – an unexpected player in neuronal proteostasis	37
Neuroimmune cleanup crews in brain injury	35
Calreticulin surface presentation can promote quality control of hematopoietic stem cells	34
Transcription factor-driven regulation of ILC1 and ILC3	34
Old macrophages lose their (circadian) rhythm	34
Subscription and Copyright Information	34
Subscription and Copyright information	33
Lymphoid tissue on the mind	32
Spiking SARS-CoV-2 antiviral immunity in the respiratory tract	32
Monoallelic expression in human immune cells: linking genotype to phenotype	32
The complex immunological role of Helicobacter in modulating cancer	32
TLR9 triggers MyD88-independent anti-inflammatory signaling in lupus	31
LNCing RNA to immunity	30
Understanding mast cell heterogeneity at single cell resolution	30
Advisory Board and Contents	29

Emerging roles for tRNAs in hematopoiesis and hematological malignancies	29
Advisory Board and Contents	28
Advisory Board and Contents	28
Signaling is the pathway to macrophage function	27
Advisory Board and Contents	27
Protists protecting food tolerance	26
Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers	25
Advisory Board and Contents	25
Chimeric antigen receptor Treg therapy in transplantation	25
Advisory Board and Contents	25
Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities	25
Targeting the metabolism of tumor-infiltrating regulatory T cells	25
Putative role of STING-mitochondria associated membrane crosstalk in immunity	25
The predictive power of systems immunology	24
Overcoming gender bias in STEM	24
Subscription and Copyright Information	24
Sensory nerves unlock the TOLL-7 gate for cancer spread	23
Th17 cells: from gut homeostasis to CNS pathogenesis	23
New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies	23
Protect, repair, rewire, and defend	23
BCG vaccination induces cross-protective immunity against pathogenic microorganisms	23
Harder, better, faster, stronger: biochemistry and biophysics in the immunosurveillance concert	23
Sensory neuronal control of skin barrier immunity	22
Multiple sclerosis: role of meningeal lymphoid aggregates in progression independent of relapse activity	22
Immunotherapy response-associated Akkermansia: canary in a coal mine?	22
Partners and guardians of the nervous and immune systems	21
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy	21
TCR-sequencing in cancer and autoimmunity: barcodes and beyond	21
Subscription and Copyright Information	21
Regulation and impact of tumor-specific CD4+ T cells in cancer and immunotherapy	21
B cell phylogenetics in the single cell era	21
Immune-featured decidual stromal cells: pregnancy's multitasking superstars	21
Life and death of tolerogenic dendritic cells	20
How do autoimmune CD4+ T cells handle exhaustion?	20
Lymph node fibroblast-produced extracellular matrix shapes immune function	20
Feeding the wrath with myelin	20
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases	20
CD8+ Tregs kill pathogenic cells to avert autoimmunity	20
The diversity of cGLR receptors: shedding new light on innate immunity	20
COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle	20
Enemy or ally? Fasting as an essential regulator of immune responses	19
RORγt protein modifications and IL-17-mediated inflammation	19
SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences	19
Inflammasome diversity: exploring novel frontiers in the innate immune response	19
cGAS-like receptors: back to the future	19
The extracellular matrix and immunity: breaking the old barrier in cancer	18
Early clues regarding the pathogenesis of long-COVID	17
Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment	17
Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions	17
Human neutrophil kinetics: a call to revisit old evidence	17
Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunity	17
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis	17
Why are there so few (or so many) circulating coronaviruses?	17
Finding your niche: immune evasion in quiescent tumor reservoirs	17
ICOS-play: dressing T cells for residency	16
Advisory Board and Contents	16
Subscription and Copyright Information	16
Macrophage states: there's a method in the madness	15
Exhausted CD8+ T cells face a developmental fork in the road	15
Physiological role of cytokines in the regulation of mammalian metabolism	15
Turning cold tumors hot: from molecular mechanisms to clinical applications	14
Breaking down IgA: Tomasiella immunophila enlightens microbiome–immune interactions	14
CD4+ T cells that help B cells – a proposal for uniform nomenclature	14
Unraveling B cell trajectories at single cell resolution	14
Restriction factors regulating human herpesvirus infections	14
Lipid regulation of NLRP3 inflammasome activity through organelle stress	14
RNA circuits and RNA-binding proteins in T cells	14
Inflammasomopathies: mechanisms and disease signatures	14
Channel plan: control of adaptive immune responses by pannexins	13
Cancer germline antigens and tumor-agnostic CD8+ T cell evasion	13
New insights into transcription elongation control of HIV-1 latency and rebound	13
A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development	13
Advisory Board and Contents	13
Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine	13
T cell TET2 disruption cuts the breaks on antitumor CAR T cell therapy	13
Prenatal inflammation shapes microglial immune response into adulthood	13
Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?	12
The meningeal lymphatics: regulators of Aβ immunotherapy?	12
Advisory Board and Contents	12
Unleashing TNF cytotoxicity to enhance cancer immunotherapy	12

Zebrafish: an underutilized tool for discovery in host–microbe interactions	12
Cytokine-skewed Tfh cells: functional consequences for B cell help	12
Baby’s skin bacteria: first impressions are long-lasting	12
Monoclonal antibodies lock down SARS-CoV-2 spike	12
Introducing the 'Significance' box in Trends in Immunology articles	11
Advisory Board and Contents	11
Uniting innate and adaptive immunity in glioblastoma; an α-CTLA-4 quest	11
Advisory Board and Contents	11
Aching to defend: spleen innervation drives humoral immunity	11
Subscription and Copyright Information	11
Subscription and Copyright Information	11
A new perspective on mesenchymal–immune interactions in adipose tissue	10
Host immunity and cellular responses to bacterial outer membrane vesicles	10
Regional specialization within the mammalian respiratory immune system	10
Trust your gut: an early life lesson for T cells	10
Enhancing tumor immunity via in vivo cDC1 reprogramming	10
Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond	10
Ghrelin and leptin regulating wound healing	10
Affinity-independent plasma cell differentiation in germinal centers	10
Humans pIKK-up NLRP3 to skip NEK7	10
Towards a quantitative theory of tolerance	10
Inflammatory and immune effects on tumor progression	10
SARS-CoV-2 vaccination washes away original antigenic sin	9
Malaria: influence of Anopheles mosquito saliva on Plasmodium infection	9
Subscription and Copyright Information	9
Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death	9
Developing cultural humility in immunology and STEMM mentoring	9
Locus architecture and RAG scanning determine antibody diversity	9
Subscription and Copyright Information	9
Approaches for studying neuroimmune interactions in Alzheimer’s disease	9
OTULIN in NF-κB signaling, cell death, and disease	9
Targeting immune evasion in hepatocellular carcinoma-initiating cells	9
Shaped by the epithelium – postnatal immune mechanisms of oral homeostasis	9
Gutsy sensations modulate intestinal disease	8
Structure-based mechanisms of 2′3′-cGAMP intercellular transport in the cGAS–STING immune pathway	8
Multiscale geometric and topological analyses for characterizing and predicting immune responses from single cell data	8
Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks	8
Microglia pack a toolbox for life	8
Emerging mechanisms of immunocoagulation in sepsis and septic shock	8
Memory B cell diversity: insights for optimized vaccine design	8
Mutagenic repair during antibody diversification: emerging insights	8
Pseudomonas aeruginosa: a pathogen making itself at home	8
Deciphering SARS-CoV-2 evolution under antibody immune pressure	8
Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus	8
ADAR1 and ZBP1 in innate immunity, cell death, and disease	8
Advisory Board and Contents	7
The putative contribution of cellular senescence to driving tauopathies	7
Immunomodulatory impact of α-fetoprotein	7
Helper ILCs in the human hematopoietic system	7
Over but not gone: lingering epigenetic effects of COVID-19	7
Embryonic microglia maintain the brain's cortical fault lines	7
Genetic conflicts and the origin of self/nonself-discrimination in the vertebrate immune system	7
C3-targeted therapy in periodontal disease: moving closer to the clinic	7
The Vibrio cholerae maneuver	7
Subscription and Copyright Information	7
The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder	7
Sodium and its manifold impact on our immune system	7
Advisory Board and Contents	6
Tracking tumor-specific CD8+ T cell responses	6
Why do central nervous system barriers host a diverse immune landscape?	6
Recombinant snake antivenoms get closer to the clinic	6
Towards decoding the space-time continuum of pregnancy	6
Oxidative stress, malaria, sickle cell disease, and innate immunity	6
Advisory Board and Contents	6
Allogeneic hematopoietic stem cell transplantation: lessons learned by a molecular immunologist/transplant patient	6
An immune window of opportunity to prevent childhood B cell leukemia	6
Modeling human immune responses to vaccination in vitro	5
Leveraging deep learning to improve vaccine design	5
The heightened importance of the microbiome in cancer immunotherapy	5
Macrophage immunotherapy: overcoming impediments to realize promise	5
Boosting peripheral immunity to fight neurodegeneration in the brain	5
Complement(ing) long-COVID thromboinflammation and pathogenesis	5
NF-κB: blending metabolism, immunity, and inflammation	5
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Tissue-specific differentiation of CD8+ resident memory T cells	5
Decoding microglial functions in Alzheimer’s disease: insights from human models	5
Deconstructing iNKT cell development at single-cell resolution	5
Approaches for studying human macrophages	5
Advisory Board and Contents	5
Diet and immune response: how today’s plate shapes tomorrow’s health	5
Leveraging human immune organoids for rational vaccine design	4
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Analyzing the unperturbed HIV-1 T cell reservoir	4
Liquid–liquid phase separation in innate immunity	4
Mutant ARID1A: igniting cancer immunotherapy	4
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Advisory Board and Contents	4
Sterols in asthma	4
Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis	4
Beyond antiviral: role of IFN-I in brain development	4
Lipopolysaccharide delivery systems in innate immunity	4
On developmental programming of the immune system	4
Splicing dysregulation in human hematologic malignancies: beyond splicing mutations	4
Keeping T cell memories in mind	4
The extracellular matrix in solid tumor immunotherapy	4