OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Pharmacology is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling	92
Native botulinum toxin type A vs. redesigned botulinum toxins in pain: What did we learn so far?	86
Editorial Board	75
The role of extracellular ATP in homeostatic immune cell migration	60
Therapeutic Hurdles in Acute Myeloid Leukemia: Leukemic Stem Cells, Inflammation and Immune Dysfunction	58
The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies	57
Splice-switching as cancer therapy	44
Lipid raft disruption as an opportunity for peripheral analgesia	43
Recent advances in emerging PCOS therapies	42
Gastrointestinal issue: Advances in gastrointestinal oncology	34
Optofluidic neural interfaces for in vivo photopharmacology	33
Editorial Board	33
Artemisinins and their impact on inhibitory neurotransmission	32
Technological advancements to study cellular signaling pathways in inherited retinal degenerative diseases	31
Current status of hepatitis delta	31
Optic nerve regeneration: Potential treatment approaches	29
Considerations for individualized first-line systemic treatment in advanced hepatocellular carcinoma	29
Pancreatic alpha cells and glucagon secretion: Novel functions and targets in glucose homeostasis	29
Editorial overview: Special issue on “Rheumatology: Therapeutic advances for autoimmune and musculoskeletal diseases”	29
Photo-isomerizable tweezers to probe ionotropic receptor mechanisms	29
Three-dimensional culture models to study glioblastoma — current trends and future perspectives	29
Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistance	28
Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus	28
Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration	26
A review of emerging neuroprotective and neuroregenerative therapies in traumatic spinal cord injury	26

Editorial Board	26
Animal models of cystic fibrosis in the era of highly effective modulator therapies	25
Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration	25
Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis	25
Exercise as a drug for glucose management and prevention in type 2 diabetes mellitus	24
Effects of functional electrical stimulation on muscle health after spinal cord injury	24
Plant-based vaccine research development against viral diseases with emphasis on Ebola virus disease: A review study	22
Integrating single-cell transcriptomics and microcircuit computer modeling	22
Current state of CFTR modulators for treatment of Cystic Fibrosis	22
Editorial Board	22
Gene therapies for RyR1-related myopathies	21
Promising therapeutic approaches in pulmonary arterial hypertension	21
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside	21
Photopharmacological approaches for dissecting potassium channel physiology	21
Therapeutic approaches in different congenital myopathies	21
Very-low-calorie ketogenic diet: An alternative to a pharmacological approach to improve glycometabolic and gonadal profile in men with obesity	20
Next-gen therapeutics to spare and expand beta-cell mass	20
Editorial overview: An initiative toward Ebolavirus disease (EVD) free world: An edited special anti-infective issue on Ebola virus disease	20
Antihypertensive effect of soybean bioactive peptides: A review	19
Oncohistone-sculpted epigenetic mechanisms in pediatric brain cancer	19
Non-alcoholic fatty liver disease: Current therapeutic options	19
Treatment of severe alcoholic hepatitis: A systematic review	19
Drug development for the treatment of RyR1-related skeletal muscle diseases	19
Autophagy in neuronal physiology and disease	19
Oligonucleotide-based therapies for cystic fibrosis	19
Host membrane proteins in the HIV-induced membrane fusion: Role in pathogenesis and therapeutic potential of autoantibodies	18
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”	18
Photopharmacological control of cell signaling with photoswitchable lipids	17
Organotypic human ex vivo models for coronavirus disease 2019 research and drug development	17
Nutraceuticals in mental diseases — Bridging the gap between traditional use and modern pharmacology	17
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer	17
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration	17
Antibiotics, the microbiome and gastrointestinal cancers: A causal interference?	16
Purinergic signalling in graft-versus-host disease	16
MicroRNA: A mediator of diet-induced cardiovascular protection	16
Editorial overview: COVID-19 therapy: From lung disease to systemic disorder	16
Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction	15
Light-activated receptor tyrosine kinases: Designs and applications	15
PRRT for higher-grade neuroendocrine neoplasms: What is still acceptable?	15
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway	15
Functional role of the ER stress transducer IRE1α in CF airway epithelial inflammation	15
Adoptive cell therapy for solid tumors: Chimeric antigen receptor T cells and beyond	15
Fluorescent chemigenetic actuators and indicators for use in living animals	15
Targeting fibroblast-like synoviocytes in rheumatoid arthritis	15
Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies	15
Editorial Board	15
Targeting the endocannabinoid system for the management of low back pain	15
Advances in tethered photopharmacology for precise optical control of signaling proteins	14
The expanding role of split protein complementation in opsin-free optogenetics	14
Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscle	14

CFTR RNA- and DNA-based therapies	14
Editorial overview: Introduction to the musculoskeletal section of current opinion in pharmacology	14
Immune dysfunction after spinal cord injury – A review of autonomic and neuroendocrine mechanisms	14
Modulation of immune response in Ebola virus disease	13
Environmental toxicants, brown adipose tissue, and potential links to obesity and metabolic disease	13
Towards eradication of HBV: Treatment approaches and status of clinical trials	13
Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation	13
TMEM16A (ANO1) as a therapeutic target in cystic fibrosis	13
Caffeine consumption and schizophrenia: A highlight on adenosine receptor–independent mechanisms	13
Editorial Board	13
Is there still a place for radiotherapy in gastric cancer?	13
Novel treatments for dry eye syndrome	13
Editorial Board	13
NMR applications to GPCR recognition by peptide ligands	13
Corrigendum to “Antihypertensive effect of soybean bioactive peptides: A review” [Curr Opin Pharmacol (62) (2022) 74–81]	13
Innate and adaptive immune mechanisms regulating central nervous system remyelination	13
Effects of protein glycation and protective mechanisms against glycative stress	13
Auxiliary subunits of the AMPA receptor: The Shisa family of proteins	13
AI-driven GPCR analysis, engineering, and targeting	13