OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Pharmacology is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-01-01 to 2025-01-01.)

Article	Citations
Recent advances in emerging PCOS therapies	64
Metabolic comorbidities of adrenal insufficiency: Focus on steroid replacement therapy and chronopharmacology	63
Interrogating the function of GABAA receptors in the brain with optogenetic pharmacology	59
Novel strategies to promote resolution of inflammation to treat lower extremity artery disease	54
The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies	48
Editorial overview: Immune regulation and cancers	47
Editorial Board	45
Established and novel human translational models to advance cystic fibrosis research, drug discovery, and optimize CFTR-targeting therapeutics	42
Routine neoadjuvant chemotherapy for all patients with resectable pancreatic ductal adenocarcinoma? A review of the evidence	41
Editorial overview – 2022 respiratory issue: Cystic fibrosis pathophysiology, models, and novel therapies	40
Impact of amino acids on microglial activation and CNS remyelination	37
The role of extracellular ATP in homeostatic immune cell migration	35
Lipid raft disruption as an opportunity for peripheral analgesia	32
Editorial Board	32
Editorial Board	31
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration	31
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”	30
Host membrane proteins in the HIV-induced membrane fusion: Role in pathogenesis and therapeutic potential of autoantibodies	29
Organotypic human ex vivo models for coronavirus disease 2019 research and drug development	29
Editorial Board	28
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer	27
Quantitative assessment of volumetric muscle loss: Dual-energy X-ray absorptiometry and ultrasonography	26
Drug effects on neuropeptides and their receptors: Big hopes but moderate success in the treatment of chronic pain	25
Non-alcoholic fatty liver disease: Current therapeutic options	25
MicroRNA: A mediator of diet-induced cardiovascular protection	25

From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling	25
Dietary serine supplementation: Friend or foe?	24
Beyond the AMPA receptor: Diverse roles of SynDIG/PRRT brain-specific transmembrane proteins at excitatory synapses	24
Splice-switching as cancer therapy	23
Nutraceuticals in mental diseases — Bridging the gap between traditional use and modern pharmacology	23
The 2013–2016 Ebola virus disease outbreak in West Africa	23
Stress, kisspeptin, and functional hypothalamic amenorrhea	22
Nutraceuticals use and type 2 diabetes mellitus	22
New CARs on and off the road: challenges and new developments in CAR-T cell therapy	21
Current pharmacological treatment of hepatocellular carcinoma	21
Role of metformin and other metabolic drugs in the prevention and therapy of endocrine-related cancers	21
Emerging drugs for the treatment of primary sclerosing cholangitis	21
Circulating factors that influence the central nervous system remyelination	21
Metabolic regulation of tissue-resident memory CD8+ T cells	21
Pharmacologic treatment of gastroparesis: What is (still) on the horizon?	20
Photopharmacological control of cell signaling with photoswitchable lipids	20
Native botulinum toxin type A vs. redesigned botulinum toxins in pain: What did we learn so far?	19
Targeting the soluble epoxide hydrolase pathway as a novel therapeutic approach for the treatment of pain	18
N-methyl-d-aspartate receptor function in neuronal and synaptic development and signaling	17
The active kinome: The modern view of how active protein kinase networks fit in biological research	17
Photoswitchable allosteric modulators for metabotropic glutamate receptors	17
How organoids can improve personalized treatment in patients with gastro-esophageal tumors	17
Prospects for COPD treatment	17
The blood pressure lowering effects of glucagon-like peptide-1 receptor agonists: A mini-review of the potential mechanisms	17
Tropical fruits from Australia as potential treatments for metabolic syndrome	17
Interventional functional diagnostics in gastrointestinal endoscopy: Combining diagnostic and therapeutic tools in the endoscopy suite with the functional lumen imaging probe	17
Corrigendum to ‘JAK inhibitors: Current position in treatment strategies for use in inflammatory bowel disease’	17
Elexacaftor–tezacaftor–ivacaftor: The new paradigm to treat people with cystic fibrosis with at least one p.Phe508del mutation	17
Integrating network pharmacology: The next-generation approach in ocular drug discovery	17
Hormonal drugs for the treatment of endometriosis	17
Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options	17
Disease-modifying therapies in short bowel syndrome	16
Corticosteroids and circadian rhythms in the cardiovascular system	16
New developments in treatments for systemic vasculitis	16
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway	16
Adenosine signaling as target in cardiovascular pharmacology	16
Chronotherapy of cardiac and vascular disease: timing medications to circadian rhythms to optimize treatment effects and outcomes	16
Targeting the altered duodenal microenvironment in functional dyspepsia	15
Targeting fibroblast-like synoviocytes in rheumatoid arthritis	15
Remyelinating strategies: What can be learned from normal brain development	15
Considerations for individualized first-line systemic treatment in advanced hepatocellular carcinoma	15
Editorial Board	15
Polyphenols affect the humoral response in cancer, infectious and allergic diseases and autoimmunity by modulating the activity of TH1 and TH2 cells	15
Editorial overview: Endocrine and metabolic diseases (2023)	14
Gastrointestinal issue: Advances in gastrointestinal oncology	14
Cancer 2021: New therapeutic approaches for the treatment of cancer — building on advances in cancer biology and the molecular genetics of cancer	14
Functional role of the ER stress transducer IRE1α in CF airway epithelial inflammation	14
Editorial Board	14
A computational overview on phylogenetic characterization, pathogenic mutations, and drug targets for Ebola virus disease	14
Editorial overview: COVID-19 therapy: From lung disease to systemic disorder	14

Editorial Board	13
From serendipity to rational drug design in brain disorders: in silico, in vitro, and in vivo approaches	13
Optofluidic neural interfaces for in vivo photopharmacology	13
Recent developments and strategies of Ebola virus vaccines	13
Practical application of breath tests in disorders of gut–brain interaction	13
Artemisinins and their impact on inhibitory neurotransmission	13
Editorial overview: Neuroscience: Advances in the field	13
Bioprinted nanocomposite hydrogels: A proposed approach to functional restoration of skeletal muscle and vascular tissue following volumetric muscle loss	13
The complement pathway as a therapeutic target for neovascular age-related macular degeneration-mediated subretinal fibrosis	13
Technological advancements to study cellular signaling pathways in inherited retinal degenerative diseases	13
Targeting intramuscular adipose tissue expansion to preserve contractile function in volumetric muscle loss: A potentially novel therapy?	13
Antibiotics, the microbiome and gastrointestinal cancers: A causal interference?	13
Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction	13
Nonsteroidal mineralcorticoid receptor antagonists: Novel therapeutic implication in the management of patients with type 2 diabetes	13
Astrocytes as cellular mediators of cue reactivity in addiction	12
Optic nerve regeneration: Potential treatment approaches	12
Type 2 diabetic women are not small type 2 diabetic men: Sex-and-gender differences in antidiabetic drugs	12
The potential pharmacological mechanisms of β-hydroxybutyrate for improving cognitive functions	12
The hypodopaminergic state ten years after: transcranial magnetic stimulation as a tool to test the dopamine hypothesis of drug addiction	12
Current status of hepatitis delta	12
Photo-isomerizable tweezers to probe ionotropic receptor mechanisms	12
Hepatic arterial infusion chemotherapy for patients with hepatocellular carcinoma: Applicability in Western countries	12
Applications of chemogenetics in non-human primates	12
Targeting drug memory reconsolidation: a neural analysis	12
Purinergic signalling in graft-versus-host disease	12