Current Opinion in Pharmacology

Article	Citations
Targeting CD73 to augment cancer immunotherapy	73
Next-generation drug repurposing using human genetics and network biology	56
The molecular link between oxidative stress, insulin resistance, and type 2 diabetes: A target for new therapies against cardiovascular diseases	49
Nanotechnology in pulmonary medicine	45
Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options	44
Prospects for COPD treatment	43
Alleviating tumor hypoxia with perfluorocarbon-based oxygen carriers	43
Adipose tissue depot differences in adipokines and effects on skeletal and cardiac muscle	41
Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus	40
Transforming targeted cancer therapy with PROTACs: A forward-looking perspective	35
The regulatory roles of dietary fibers on host health via gut microbiota-derived short chain fatty acids	34
Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy	32
Targeting the A2AR in cancer; early lessons from the clinic	31
Bile acid-activated receptors and the regulation of macrophages function in metabolic disorders	31
Targeting B cells for inflammatory bowel disease treatment: back to the future	31
Recent discoveries in HIV-1 reverse transcriptase inhibitors	30
Gut microbiota and regulation of myokine-adipokine function	29
Myokines and adipokines in sarcopenia: understanding cross-talk between skeletal muscle and adipose tissue and the role of exercise	28
Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistance	28
A review of emerging neuroprotective and neuroregenerative therapies in traumatic spinal cord injury	27
Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies	27
Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications	27
Antihypertensive effect of soybean bioactive peptides: A review	27
Targeting fibroblast-like synoviocytes in rheumatoid arthritis	27
Exercise and browning of white adipose tissue – a translational perspective	26

Astrocytes as cellular mediators of cue reactivity in addiction	24
Glutamate receptors and metaplasticity in addiction	24
Exercise as a drug for glucose management and prevention in type 2 diabetes mellitus	24
N-methyl-d-aspartate receptor function in neuronal and synaptic development and signaling	23
Monitoring vedolizumab and ustekinumab drug levels in patients with inflammatory bowel disease: hype or hope?	23
Circadian control of human cardiovascular function	23
The role of the liver in the modulation of glucose and insulin in non alcoholic fatty liver disease and type 2 diabetes	23
Chronotherapy of cardiac and vascular disease: timing medications to circadian rhythms to optimize treatment effects and outcomes	23
Treatments for COVID-19: Lessons from 2020 and new therapeutic options	22
Treatment of early rheumatoid arthritis: Methotrexate and beyond	22
Non-nucleoside reverse transcriptase inhibitors (NNRTIs): a brief overview of clinically approved drugs and combination regimens	22
Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis	22
Renal protection with glucagon-like peptide-1 receptor agonists	21
Alpha1-antitrypsin deficiency: New therapies on the horizon	20
Drug-resistance in rheumatoid arthritis: the role of p53 gene mutations, ABC family transporters and personal factors	20
Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use disorder	20
Current advances in the treatment of systemic sclerosis	20
The role of faecal microbiota transplantation in the treatment of inflammatory bowel disease	20
Metabolic adaptations after bariatric surgery: adipokines, myokines and hepatokines	20
Rethinking the clinical management of volumetric muscle loss in patients with spinal cord injury: Synergy among nutritional supplementation, pharmacotherapy, and rehabilitation	20
Circadian influence on inflammatory response during cardiovascular disease	20
The pleiotropic roles of autophagy in Alzheimer's disease: From pathophysiology to therapy	20
Anti-inflammatory glucocorticoid action: genomic insights and emerging concepts	19
Disruption of energy utilization in diabetic cardiomyopathy; a mini review	19
MicroRNAs as mediators of drug resistance mechanisms	18
Environmental enrichment-inspired pharmacological tools for the treatment of addiction	18
Does probiotics work for bacterial vaginosis and vulvovaginal candidiasis	18
Adoptive cell therapy for solid tumors: Chimeric antigen receptor T cells and beyond	18
Current state of CFTR modulators for treatment of Cystic Fibrosis	18
Applications of chemogenetics in non-human primates	18
Intersection of immunometabolism and immunosenescence during aging	17
TMEM16A (ANO1) as a therapeutic target in cystic fibrosis	17
Updated pharmacological effects of Lonicerae japonicae flos, with a focus on its potential efficacy on coronavirus disease–2019 (COVID-19)	17
New drugs in the pipeline for the treatment of inflammatory bowel diseases: what is coming?	17
Role of the endocannabinoid system in the regulation of the skeletal muscle response to exercise	17
Cost-effectiveness of therapeutic drug monitoring in inflammatory bowel disease	17
Photopharmacological control of cell signaling with photoswitchable lipids	17
Testosterone therapy for prevention and reversal of type 2 diabetes in men with low testosterone	16
Beyond antibodies: ankyrins and DARPins. From basic research to drug approval	16
Kinase inhibitors in the treatment of obstructive pulmonary diseases	16
Phosphodiesterase isoforms and cAMP compartments in the development of new therapies for obstructive pulmonary diseases	16
Current pharmacological intervention and development of targeting IVIG resistance in Kawasaki disease	16
Integrating the roles of liver X receptors in inflammation and infection: mechanisms and outcomes	16
The 2013–2016 Ebola virus disease outbreak in West Africa	15
Probing function in 3D neuronal cultures: A survey of 3D multielectrode array advances	15
Effects of functional electrical stimulation on muscle health after spinal cord injury	15
Lipid deposition and metaflammation in diabetic kidney disease	14
Prospects for severe asthma treatment	14
Optical control of Class A G protein-coupled receptors with photoswitchable ligands	14
The hypodopaminergic state ten years after: transcranial magnetic stimulation as a tool to test the dopamine hypothesis of drug addiction	14

Oxygenation and A2AR blockade to eliminate hypoxia/HIF-1α-adenosinergic immunosuppressive axis and improve cancer immunotherapy	14
Immunogenicity, breakthrough infection, and underlying disease flare after SARS-CoV-2 vaccination among individuals with systemic autoimmune rheumatic diseases	14
Regulation of adipose tissue and skeletal muscle substrate metabolism by the stomach-derived hormone, ghrelin	14
RNAi therapeutics: an antiviral strategy for human infections	14
Lipid metabolism as a mechanism of immunomodulation in macrophages: the role of liver X receptors	14
Microbiota-gut-brain axis: A novel potential target of ketogenic diet for epilepsy	14
The e-psychonaut drugs’ psychopharmacology	14
Lynx1 prototoxins: critical accessory proteins of neuronal nicotinic acetylcholine receptors	14
Mechanisms underlying N3-PUFA regulation of white adipose tissue endocrine function	14
Non-alcoholic fatty liver disease: Current therapeutic options	14
Role of intestinal glucose absorption in glucose tolerance	13
The changing landscape of the cystic fibrosis lung environment: From the perspective of Pseudomonas aeruginosa	13
Genetic risk scores and personalization of care in fatty liver disease	13
Role of CD38/cADPR signaling in obstructive pulmonary diseases	13
Immune dysfunction after spinal cord injury – A review of autonomic and neuroendocrine mechanisms	13
Pharmacological modulation of GABAA receptors	13
Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration	13
Targeting cellular senescence as a new approach to chronic obstructive pulmonary disease therapy	12
Recent insights into astrocytes as therapeutic targets for demyelinating diseases	12
Tackling inflammation in atherosclerosis: Are we there yet and what lies beyond?	12
Targeting drug memory reconsolidation: a neural analysis	12
Therapeutics development for Ebola virus disease: A recent scenario	12
Promising therapeutic approaches in pulmonary arterial hypertension	12
Design strategies for long-acting anti-HIV pharmaceuticals	12
Elexacaftor–tezacaftor–ivacaftor: The new paradigm to treat people with cystic fibrosis with at least one p.Phe508del mutation	12
Contribution of the bone marrow stromal cells in mediating drug resistance in hematopoietic tumors	12
Molecular routes to sarcopenia and biomarker development: per aspera ad astra	12
Evolving understanding of cardiovascular protection by SGLT2 inhibitors: focus on renal protection, myocardial effects, uric acid, and magnesium balance	12
Targeting cellular senescence as a novel treatment for osteoarthritis	11
Pharmacology of pannexin channels	11
Recent advances in the role of interleukin-6 in health and disease	11
Quantitative assessment of volumetric muscle loss: Dual-energy X-ray absorptiometry and ultrasonography	11
Highland mate: Edible and functional foods in traditional medicine for the prevention and treatment of hypoxia-related symptoms	11
Molecular link between circadian clocks and cardiac function: a network of core clock, slave clock, and effectors	11
Three-dimensional culture models to study glioblastoma — current trends and future perspectives	11
Recent advances in emerging PCOS therapies	11
Role of metformin and other metabolic drugs in the prevention and therapy of endocrine-related cancers	11
Targeting PKC in microglia to promote remyelination and repair in the CNS	11
Oxygen therapeutic agents to target hypoxia in cancer treatment	11
Hormonal drugs for the treatment of endometriosis	11
Stress, kisspeptin, and functional hypothalamic amenorrhea	11
Current pharmacological treatment of hepatocellular carcinoma	11
Smad-dependent pathways in the infarcted and failing heart	10
Metabokines in the regulation of systemic energy metabolism	10
Preclinical pharmacology modeling of chimeric antigen receptor T therapies	10
Polyphenols affect the humoral response in cancer, infectious and allergic diseases and autoimmunity by modulating the activity of TH1 and TH2 cells	10
Metformin: still the sweet spot for CV protection in diabetes?	10
JAK inhibitors: current position in treatment strategies for use in inflammatory bowel disease	10
Exploiting common aspects of obesity and cancer cachexia for future therapeutic strategies	10
An update on drug development for the treatment of metabolic (dysfunction) associated fatty liver disease: Progress and opportunities	10
Eosinophilic esophagitis: New molecules, better life?	10
Photopharmacology for vision restoration	10
Therapeutic drug monitoring of anti-tumor necrosis factor agents: lessons learned and remaining issues	10
Dietary serine supplementation: Friend or foe?	10
GLP-1 – Incretin and pleiotropic hormone with pharmacotherapy potential. Increasing secretion of endogenous GLP-1 for diabetes and obesity therapy	10
Reactive oxygen species modulators in pulmonary medicine	10
Recent developments and strategies of Ebola virus vaccines	10
Therapeutic strategies for treating juvenile idiopathic arthritis	10
Nutraceuticals use and type 2 diabetes mellitus	10
The active kinome: The modern view of how active protein kinase networks fit in biological research	10
Ubiquitin proteasome system in immune regulation and therapeutics	9
Exercise to mitigate cardiometabolic disorders after spinal cord injury	9
COVID-19 and retinal degenerative diseases: Promising link “Kaempferol”	9
Heart failure and diabetes: role of ATM	9
Impaired metabolism of oligodendrocyte progenitor cells and axons in demyelinated lesion and in the aged CNS	9
Role of fibro-adipogenic progenitor cells in muscle atrophy and musculoskeletal diseases	9
Gastrointestinal manifestations and SARS-CoV-2 infection	9
Advances in antiobesity mechanisms of capsaicin	9
Type 2 diabetic women are not small type 2 diabetic men: Sex-and-gender differences in antidiabetic drugs	9
The proton-sensing receptor ovarian cancer G-protein coupled receptor 1 (OGR1) in airway physiology and disease	9
Microglia as therapeutic targets for central nervous system remyelination	9
Circadian clocks regulate cardiac arrhythmia susceptibility, repolarization, and ion channels	9
Pharmacologic approaches to prevent skeletal muscle atrophy after spinal cord injury	9
Splice-switching as cancer therapy	9
Overview of CF lung pathophysiology	9
Understanding the biology of volumetric muscle loss for an individualized exercise rehabilitation approach in breast cancer patients	8
Repairing damaged lungs using regenerative therapy	8
Therapeutic approaches in different congenital myopathies	8
Sufficient numbers of anti-tumor T cells is a condition of maximal efficacy of anti-hypoxia-A2-adenosinergic drugs during cancer immunotherapy	8
Therapeutic avenues for restoring the gut microbiome in HIV infection	8

Neuroinflammation in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection: Pathogenesis and clinical manifestations	8
Potential mechanisms of macular degeneration protection by fatty fish consumption	8
Priming metabolism with the type 5 phosphodiesterase: the role of cGMP-hydrolyzing enzymes	8
The potential role of oxytocin in addiction: What is the target process?	8
Tropical fruits from Australia as potential treatments for metabolic syndrome	8
Emerging strategies for treating gout	8
Diabetes pharmacotherapy and circulating stem/progenitor cells. State of the art and evidence gaps	8
New trends in pharmacological control of neuropsychiatric symptoms of dementia	8
Auxiliary subunits of the AMPA receptor: The Shisa family of proteins	8
Choosing the right drug: status and future of endocannabinoid research for the prevention of drug-seeking reinstatement	8
Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?	8
Treatment of severe alcoholic hepatitis: A systematic review	8
Current status of hepatitis delta	8
Epigenetics in β-cell adaptation and type 2 diabetes	8
Novel aspects on the role of white adipose tissue in type 2 diabetes	8
Old and new biomarkers for volumetric muscle loss	8
Pituitary gonadotroph-specific patterns of gene expression and hormone secretion	8
Pharmacologic approaches to HIV-associated neurocognitive disorders	8
Caffeine consumption and schizophrenia: A highlight on adenosine receptor–independent mechanisms	8
Therapeutic potential and challenges of bitter taste receptors on lung cells	8
Novel treatments in multidrug-resistant tuberculosis	8
Treatment advances in antiphospholipid syndrome: 2022 update	8
Pancreatic alpha cells and glucagon secretion: Novel functions and targets in glucose homeostasis	8
GIP(3-30)NH2 – a tool for the study of GIP physiology	8
Molecular control of tissue-resident macrophage identity by nuclear receptors	7
Rethinking the adenosine-A2AR checkpoint: implications for enhancing anti-tumor immunotherapy	7
Nutrient weight against sarcopenia: regulation of the IGF-1/PI3K/Akt/FOXO pathway in quinoa metabolites	7
Advances in tethered photopharmacology for precise optical control of signaling proteins	7
Class C GPCRs in the airway	7
Very-low-calorie ketogenic diet: An alternative to a pharmacological approach to improve glycometabolic and gonadal profile in men with obesity	7
Functional implications of neutrophil metabolism during ischemic tissue repair	7
Small molecule screening as an approach to encounter inefficient myelin repair	7
Precision medicine in idiopathic pulmonary fibrosis therapy: From translational research to patient-centered care	7
Potential of glucocorticoids to treat intestinal inflammation during sepsis	7
Metabolic comorbidities of adrenal insufficiency: Focus on steroid replacement therapy and chronopharmacology	7
Precision medicine for rare diseases: The times they are A-Changin'	7
Cancer synthetic vulnerabilities to protein arginine methyltransferase inhibitors	7
Animal models of cystic fibrosis in the era of highly effective modulator therapies	7
CFTR RNA- and DNA-based therapies	7
The potential pharmacological mechanisms of β-hydroxybutyrate for improving cognitive functions	7
Metabolic regulation of tissue-resident memory CD8+ T cells	7
MicroRNA: A mediator of diet-induced cardiovascular protection	6
COVID-19 in Latin America and the caribbean region: Symptoms and morbidities in the epidemiology of infection	6
Impacts of the Filoviridae family	6
Breaking the barriers to remyelination in multiple sclerosis	6
Adipose tissue–heart crosstalk as a novel target for treatment of cardiometabolic diseases	6
Novel therapeutic avenues for kisspeptin	6
Management of blood pressure disorders in individuals with spinal cord injury	6
Bioprinted nanocomposite hydrogels: A proposed approach to functional restoration of skeletal muscle and vascular tissue following volumetric muscle loss	6
Established and novel human translational models to advance cystic fibrosis research, drug discovery, and optimize CFTR-targeting therapeutics	6
Autophagy in neuronal physiology and disease	6
Tapering biologic DMARDs in rheumatoid arthritis	6
Anabolic–androgenic steroid abuse and testicular function in men; recent insights	6
Plant-based vaccine research development against viral diseases with emphasis on Ebola virus disease: A review study	6
Towards eradication of HBV: Treatment approaches and status of clinical trials	6
Purinergic signalling in graft-versus-host disease	6
Nonsteroidal mineralcorticoid receptor antagonists: Novel therapeutic implication in the management of patients with type 2 diabetes	6
The role of diacylglycerol kinases in allergic airway disease	6
Mediterranean diet in type 2 diabetes: An updated overview of pharmacological activities of cardiometabolic and reproductive outcomes	6
The histone code in dementia: Transcriptional and chromatin plasticity fades away	6
Treatment approach to connective tissue disease-associated interstitial lung disease	6
Opportunities and challenges for nonaddictive interventions in chronic pain	6
Mechanisms of cardio-renal protection of sodium-glucose cotransporter-2 inhibitors	6
Immune tolerance therapies for autoimmune diseases: Shifting the goalpost to cure	6
RAD51 paralogs: Expanding roles in replication stress responses and repair	6
The blood pressure lowering effects of glucagon-like peptide-1 receptor agonists: A mini-review of the potential mechanisms	6