Current Opinion in Pharmacology

Article	Citations
From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling	92
Native botulinum toxin type A vs. redesigned botulinum toxins in pain: What did we learn so far?	86
Editorial Board	75
The role of extracellular ATP in homeostatic immune cell migration	60
Therapeutic Hurdles in Acute Myeloid Leukemia: Leukemic Stem Cells, Inflammation and Immune Dysfunction	58
The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies	57
Splice-switching as cancer therapy	44
Lipid raft disruption as an opportunity for peripheral analgesia	43
Recent advances in emerging PCOS therapies	42
Gastrointestinal issue: Advances in gastrointestinal oncology	34
Editorial Board	33
Optofluidic neural interfaces for in vivo photopharmacology	33
Artemisinins and their impact on inhibitory neurotransmission	32
Current status of hepatitis delta	31
Technological advancements to study cellular signaling pathways in inherited retinal degenerative diseases	31
Photo-isomerizable tweezers to probe ionotropic receptor mechanisms	29
Three-dimensional culture models to study glioblastoma — current trends and future perspectives	29
Optic nerve regeneration: Potential treatment approaches	29
Considerations for individualized first-line systemic treatment in advanced hepatocellular carcinoma	29
Pancreatic alpha cells and glucagon secretion: Novel functions and targets in glucose homeostasis	29
Editorial overview: Special issue on “Rheumatology: Therapeutic advances for autoimmune and musculoskeletal diseases”	29
Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus	28
Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistance	28
Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration	26
A review of emerging neuroprotective and neuroregenerative therapies in traumatic spinal cord injury	26

Editorial Board	26
Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis	25
Animal models of cystic fibrosis in the era of highly effective modulator therapies	25
Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration	25
Effects of functional electrical stimulation on muscle health after spinal cord injury	24
Exercise as a drug for glucose management and prevention in type 2 diabetes mellitus	24
Editorial Board	22
Plant-based vaccine research development against viral diseases with emphasis on Ebola virus disease: A review study	22
Integrating single-cell transcriptomics and microcircuit computer modeling	22
Current state of CFTR modulators for treatment of Cystic Fibrosis	22
Photopharmacological approaches for dissecting potassium channel physiology	21
Therapeutic approaches in different congenital myopathies	21
Gene therapies for RyR1-related myopathies	21
Promising therapeutic approaches in pulmonary arterial hypertension	21
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside	21
Editorial overview: An initiative toward Ebolavirus disease (EVD) free world: An edited special anti-infective issue on Ebola virus disease	20
Very-low-calorie ketogenic diet: An alternative to a pharmacological approach to improve glycometabolic and gonadal profile in men with obesity	20
Next-gen therapeutics to spare and expand beta-cell mass	20
Autophagy in neuronal physiology and disease	19
Oligonucleotide-based therapies for cystic fibrosis	19
Antihypertensive effect of soybean bioactive peptides: A review	19
Oncohistone-sculpted epigenetic mechanisms in pediatric brain cancer	19
Non-alcoholic fatty liver disease: Current therapeutic options	19
Treatment of severe alcoholic hepatitis: A systematic review	19
Drug development for the treatment of RyR1-related skeletal muscle diseases	19
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”	18
Host membrane proteins in the HIV-induced membrane fusion: Role in pathogenesis and therapeutic potential of autoantibodies	18
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration	17
Photopharmacological control of cell signaling with photoswitchable lipids	17
Organotypic human ex vivo models for coronavirus disease 2019 research and drug development	17
Nutraceuticals in mental diseases — Bridging the gap between traditional use and modern pharmacology	17
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer	17
Editorial overview: COVID-19 therapy: From lung disease to systemic disorder	16
Antibiotics, the microbiome and gastrointestinal cancers: A causal interference?	16
Purinergic signalling in graft-versus-host disease	16
MicroRNA: A mediator of diet-induced cardiovascular protection	16
Targeting fibroblast-like synoviocytes in rheumatoid arthritis	15
Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies	15
Editorial Board	15
Targeting the endocannabinoid system for the management of low back pain	15
Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction	15
Light-activated receptor tyrosine kinases: Designs and applications	15
PRRT for higher-grade neuroendocrine neoplasms: What is still acceptable?	15
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway	15
Functional role of the ER stress transducer IRE1α in CF airway epithelial inflammation	15
Adoptive cell therapy for solid tumors: Chimeric antigen receptor T cells and beyond	15
Fluorescent chemigenetic actuators and indicators for use in living animals	15
Editorial overview: Introduction to the musculoskeletal section of current opinion in pharmacology	14
Immune dysfunction after spinal cord injury – A review of autonomic and neuroendocrine mechanisms	14
Advances in tethered photopharmacology for precise optical control of signaling proteins	14

The expanding role of split protein complementation in opsin-free optogenetics	14
Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscle	14
CFTR RNA- and DNA-based therapies	14
Corrigendum to “Antihypertensive effect of soybean bioactive peptides: A review” [Curr Opin Pharmacol (62) (2022) 74–81]	13
Innate and adaptive immune mechanisms regulating central nervous system remyelination	13
Auxiliary subunits of the AMPA receptor: The Shisa family of proteins	13
Towards eradication of HBV: Treatment approaches and status of clinical trials	13
TMEM16A (ANO1) as a therapeutic target in cystic fibrosis	13
Modulation of immune response in Ebola virus disease	13
Environmental toxicants, brown adipose tissue, and potential links to obesity and metabolic disease	13
Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation	13
Novel treatments for dry eye syndrome	13
NMR applications to GPCR recognition by peptide ligands	13
Caffeine consumption and schizophrenia: A highlight on adenosine receptor–independent mechanisms	13
Editorial Board	13
Is there still a place for radiotherapy in gastric cancer?	13
Editorial Board	13
Effects of protein glycation and protective mechanisms against glycative stress	13
AI-driven GPCR analysis, engineering, and targeting	13
Mechanisms of cardio-renal protection of sodium-glucose cotransporter-2 inhibitors	12
Anabolic–androgenic steroid abuse and testicular function in men; recent insights	12
Newly identified tumor suppressor functions of ING proteins	12
Recent insights into astrocytes as therapeutic targets for demyelinating diseases	12
Functional visualization and manipulation in the marmoset brain using viral vectors	12
Probing function in 3D neuronal cultures: A survey of 3D multielectrode array advances	12
The molecular link between oxidative stress, insulin resistance, and type 2 diabetes: A target for new therapies against cardiovascular diseases	12
Repairing damaged lungs using regenerative therapy	12
Dysregulation of immune checkpoint proteins in hepatocellular carcinoma: Impact on metabolic reprogramming	12
Melatonin in neuroskeletal biology	12
Understanding the biology of volumetric muscle loss for an individualized exercise rehabilitation approach in breast cancer patients	12
Current and new targets for treating myositis	12
Physiological regulation of leptin as an integrative signal of reproductive readiness	12
Cancer synthetic vulnerabilities to protein arginine methyltransferase inhibitors	12
Targeting PKC in microglia to promote remyelination and repair in the CNS	12
Evolution of genetic testing supports precision medicine for caring Alzheimer's disease patients	12
Treatment of alcohol use disorder in patients with liver disease	12
Novel strategies to promote resolution of inflammation to treat lower extremity artery disease	11
Impact of amino acids on microglial activation and CNS remyelination	11
Corrigendum to ‘JAK inhibitors: Current position in treatment strategies for use in inflammatory bowel disease’	11
New developments in treatments for systemic vasculitis	11
Treatment advances in antiphospholipid syndrome: 2022 update	11
A review of biosimilars for rheumatoid arthritis	11
Interrogating the function of GABAA receptors in the brain with optogenetic pharmacology	11
From serendipity to rational drug design in brain disorders: in silico, in vitro, and in vivo approaches	10
Applications of chemogenetics in non-human primates	10
Update on anti-fibrotic pharmacotherapies in skeletal muscle disease	10
RAD51 paralogs: Expanding roles in replication stress responses and repair	10
Recent developments and strategies of Ebola virus vaccines	10
Hormonal drugs for the treatment of endometriosis	10
The use of hormone stimulation in male infertility	10
Interventional functional diagnostics in gastrointestinal endoscopy: Combining diagnostic and therapeutic tools in the endoscopy suite with the functional lumen imaging probe	10
Health benefits of spices in individuals with chemotherapeutic drug-induced cardiotoxicity	10
MedXercise: a promising strategy to promote remyelination	10
Biased signalling in analgesic research and development	10
The pleiotropic roles of autophagy in Alzheimer's disease: From pathophysiology to therapy	9
Testosterone therapy for prevention and reversal of type 2 diabetes in men with low testosterone	9
Editorial overview: Respiratory: Pulmonary pharmacology–The emergence of new treatments in pulmonary medicine is finally providing real therapeutic perspectives	9
Genome structure and genetic diversity in the Ebola virus	9
Therapeutic opportunities for targeting cellular senescence in progressive multiple sclerosis	9
Novel therapeutic avenues for kisspeptin	9
Current treatment and molecular targets for axial spondyloarthritis: Evidence from randomized controlled trials	9
Optical control of Class A G protein-coupled receptors with photoswitchable ligands	9
Editorial Board	9
Extracellular adenosine signaling in bone health and disease	9
Gastrointestinal manifestations and SARS-CoV-2 infection	8
Treatment approach to connective tissue disease-associated interstitial lung disease	8
Editorial Board	8
Immune-mediated food reactions in irritable bowel syndrome	8
Immunometabolic regulation of adipose tissue resident immune cells	8
When and how to use direct oral anticoagulants in patients with advanced chronic liver disease?	8
Editorial overview: Immunometabolism	8
Pharmacological modulation of GABAA receptors	8
Making myelin regenerate: Factors to consider	8
Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors	8
Towards development of disease-modifying therapy for Alzheimer's disease using redox chemical biology pathways	8
Microglia as therapeutic targets for central nervous system remyelination	8
Editorial: Nutraceuticals	7
Reprogramming cell fates towards novel cancer immunotherapies	7
Seeing is believing: Identifying remyelination in the central nervous system	7
Overview of CF lung pathophysiology	7

Adipose tissue–heart crosstalk as a novel target for treatment of cardiometabolic diseases	7
Alpha1-antitrypsin deficiency: New therapies on the horizon	7
In the heart and beyond: Mitochondrial dysfunction in heart failure with preserved ejection fraction (HFpEF)	7
COVID-19 in Latin America and the caribbean region: Symptoms and morbidities in the epidemiology of infection	7
Highland mate: Edible and functional foods in traditional medicine for the prevention and treatment of hypoxia-related symptoms	7
Breaking the barriers to remyelination in multiple sclerosis	7
The changing landscape of the cystic fibrosis lung environment: From the perspective of Pseudomonas aeruginosa	7
Impacts of the Filoviridae family	7
Impaired metabolism of oligodendrocyte progenitor cells and axons in demyelinated lesion and in the aged CNS	7
Treatments for COVID-19: Lessons from 2020 and new therapeutic options	7
Emerging strategies for treating gout	6
Editorial Board	6
Routine neoadjuvant chemotherapy for all patients with resectable pancreatic ductal adenocarcinoma? A review of the evidence	6
Dietary serine supplementation: Friend or foe?	6
Editorial overview: Endocrine and metabolic diseases (2023)	6
Current pharmacological treatment of hepatocellular carcinoma	6
New CARs on and off the road: challenges and new developments in CAR-T cell therapy	6
Cancer 2021: New therapeutic approaches for the treatment of cancer — building on advances in cancer biology and the molecular genetics of cancer	6
Drug effects on neuropeptides and their receptors: Big hopes but moderate success in the treatment of chronic pain	6
Editorial Board	6
Metabolic comorbidities of adrenal insufficiency: Focus on steroid replacement therapy and chronopharmacology	6
Stress, kisspeptin, and functional hypothalamic amenorrhea	6
The active kinome: The modern view of how active protein kinase networks fit in biological research	6