OOIR: Observatory of International Research

Papers

(The median citation count of Current Opinion in Pharmacology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Editorial Board	147
Lipid raft disruption as an opportunity for peripheral analgesia	73
Corrigendum to “From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling” [COPHAR 76 (2024) 102458]	68
Advances in pain therapeutics: Targets, mechanisms, and translational frontiers	61
Targeting strategies and immune regulatory mechanisms of CAR-macrophages in the treatment of osteosarcoma	48
Native botulinum toxin type A vs. redesigned botulinum toxins in pain: What did we learn so far?	48
From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling	42
The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies	36
The role of extracellular ATP in homeostatic immune cell migration	35
The neuro-metabolic epidemic and the CB1R paradox	34
Recent advances in emerging PCOS therapies	34
Therapeutic hurdles in acute myeloid leukemia: Leukemic stem cells, inflammation and immune dysfunction	33
Editorial Board	28
Lipidomics-driven insights into acupuncture mechanisms: From dynamic signaling networks to multi-dimensional regulations	28
Gastrointestinal issue: Advances in gastrointestinal oncology	27
CRISPR-Cas9 in acute myeloid leukaemia: Current state-of-art and future perspectives	26
Optic nerve regeneration: Potential treatment approaches	25
Considerations for individualized first-line systemic treatment in advanced hepatocellular carcinoma	25
Auricular stimulation therapy: An evidence-based practice strategy for depression	25
Advanced microneedle arrays for transdermal antibiotic delivery	24
Editorial Board	24
Editorial overview: Special issue on “Rheumatology: Therapeutic advances for autoimmune and musculoskeletal diseases”	24
Editorial Board	22
Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration	22
Pharmacological targeting of neuroimmune-synaptic interactions in Alzheimer's disease: integrating NETosis, microglia, and synaptic vulnerability	21

Innovative pipeline therapeutics in inflammatory bowel disease: Anti-tumor necrosis factor-like ligand 1A and bispecific antibodies	21
Editorial Board	21
Allogeneic double-negative T-cell therapy for acute myeloid leukemia	20
Therapeutic approaches in different congenital myopathies	20
Current state of CFTR modulators for treatment of Cystic Fibrosis	20
Valproic acid: Mechanistic insights into neuronal actions, epigenetic modulation, and clinical risk	19
Transcutaneous electrical nerve stimulation and opioid analgesia: Exploring a potential synergistic relationship	19
Acupuncture and non-invasive neuromodulation–induced neuro-endocrine-immune changes associated with the amelioration of depression-like behaviors: A systematic review of animal studies	19
Gene therapies for RyR1-related myopathies	19
Methotrexate: Integrating molecular pharmacology, systems toxicology, and precision rescue strategies	19
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside	19
Targeting the ischemic cascade: Review on approved and investigational stroke therapies	19
Lipids and lipid regulators in intraocular pressure homeostasis	17
Oligonucleotide-based therapies for cystic fibrosis	17
Strategies to enhance anti-leukaemia immunotherapy	17
Oncohistone-sculpted epigenetic mechanisms in pediatric brain cancer	17
Riluzole in neuroinflammation and neurodegeneration: Mechanistic insights and experimental validation	17
Drug development for the treatment of RyR1-related skeletal muscle diseases	16
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration	15
Chrono-immunotherapy in precision oncology: Circadian control of the tumor microenvironment and time-of-day optimization of immune checkpoint blockade	15
Smart solutions for tough infections: The rise of next-gen transdermal drug delivery	15
The role of plant-derived compounds in anti-obesity drug discovery: A molecular perspective	15
Purinergic signalling in graft-versus-host disease	14
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer	14
Acupuncture for depression: Decoding neuroimmune crosstalk and targeting anti-inflammatory mechanisms	14
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”	14
NanoPhyto formulations: A promising approach for targeted therapy of gastrointestinal infections, clinical advancements, and future perspectives	14
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway	13
Editorial overview: COVID-19 therapy: From lung disease to systemic disorder	13
Challenges in formulating transdermal systems for treating chronic skin infections	13
TMEM16A regulates MUC5AC production in airway diseases: A comprehensive review	13
Functional role of the ER stress transducer IRE1α in CF airway epithelial inflammation	13
Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction	13
Advancements in targeted therapies for acute myeloid leukemia	13
Personalizing nutrition therapy in inflammatory bowel disease: Practical applications and review of the latest studies	13
Targeting fibroblast-like synoviocytes in rheumatoid arthritis	12
Antibiotics, the microbiome and gastrointestinal cancers: A causal interference?	12
State-dependent neurotensin modulation in the brain: From network dynamics to pharmacological opportunity	12
Editorial overview: Introduction to the musculoskeletal section of current opinion in pharmacology	12
PRRT for higher-grade neuroendocrine neoplasms: What is still acceptable?	11
Targeting the endocannabinoid system for the management of low back pain	11
CFTR RNA- and DNA-based therapies	11
NMR applications to GPCR recognition by peptide ligands	11
AI-driven GPCR analysis, engineering, and targeting	11
Pharmacoutilization data-driven artificial intelligence–assisted diagnosis algorithm to improve the pharmacological treatment of pain and agitation in patients suffering from severe dementia	10
Novel approaches to CAR T cell target identification in acute myeloid leukemia	10
Novel treatments for dry eye syndrome	10
Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscle	10
Revolutionizing UC monitoring: The emerging role of intestinal ultrasound	10
The expanding role of split protein complementation in opsin-free optogenetics	10

Effects of protein glycation and protective mechanisms against glycative stress	9
Environmental toxicants, brown adipose tissue, and potential links to obesity and metabolic disease	9
Editorial Board	9
Is there still a place for radiotherapy in gastric cancer?	9
Editorial Board	9
Corrigendum to “Antihypertensive effect of soybean bioactive peptides: A review” [Curr Opin Pharmacol (62) (2022) 74–81]	9
Physiological regulation of leptin as an integrative signal of reproductive readiness	8
Mechanisms of cardio-renal protection of sodium-glucose cotransporter-2 inhibitors	8
Recent insights into astrocytes as therapeutic targets for demyelinating diseases	8
Newly identified tumor suppressor functions of ING proteins	8
Anabolic–androgenic steroid abuse and testicular function in men; recent insights	8
Editorial overview: Advanced therapies and new targets in ocular diseases	8
Real-world evidence supporting orphan drugs approvals for rare neuromuscular disorders in the European Union and the United States: Review of public assessment reports (2015–2025)	8
Revolutionizing Crohn's disease monitoring: The emerging role of intestinal ultrasound	8
Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation	8
Current and new targets for treating myositis	8
Novel strategies to promote resolution of inflammation to treat lower extremity artery disease	7
Electro-microbial interplay in the gut–brain axis: An emerging paradigm for gut microbiota modulation via vagus nerve stimulation	7
New developments in treatments for systemic vasculitis	7
RAD51 paralogs: Expanding roles in replication stress responses and repair	7
Treatment advances in antiphospholipid syndrome: 2022 update	7
Nutritional composition of diets for inducing and maintaining remission in inflammatory bowel diseases: from bedside to plate	7
Interventional functional diagnostics in gastrointestinal endoscopy: Combining diagnostic and therapeutic tools in the endoscopy suite with the functional lumen imaging probe	7
Precision medicine and immunotherapeutic approaches for relapsed/refractory paediatric acute myeloid leukaemia	7
Impact of amino acids on microglial activation and CNS remyelination	7
Lipid-based nanocarriers in topical applications for skin infections	7
CPX-351: From preclinical studies to future directions	7
Glymphatic dysfunction in neurodegeneration: From impaired clearance to mechanism-driven therapeutic innovation	6
Update on anti-fibrotic pharmacotherapies in skeletal muscle disease	6
Recent innovations in clinical trial design for inflammatory bowel disease	6
Colloidal drug delivery systems for infectious diseases of skin	6
The use of hormone stimulation in male infertility	6
Hormonal drugs for the treatment of endometriosis	6
Research progress and prospect on the mechanisms of non-invasive neuromodulation therapy and acupuncture in treating cognitive impairment after traumatic brain injury	6
Biased signalling in analgesic research and development	6
Editorial Board	6
Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors	5
Novel therapeutic avenues for kisspeptin	5
Making myelin regenerate: Factors to consider	5
High-quality randomised controlled trials of acupuncture interventions for autism spectrum disorder in the last 10 years (2015–2024): A literature review	5
Treatment approach to connective tissue disease-associated interstitial lung disease	5
Current treatment and molecular targets for axial spondyloarthritis: Evidence from randomized controlled trials	5
Editorial Board	5
Extracellular adenosine signaling in bone health and disease	5
Reprogramming cell fates towards novel cancer immunotherapies	4
Molecular insights driving personalized therapies	4
In the heart and beyond: Mitochondrial dysfunction in heart failure with preserved ejection fraction (HFpEF)	4
Immune-mediated food reactions in irritable bowel syndrome	4
Editorial: Nutraceuticals	4
The underlying mechanisms of acupuncture for alleviating pain-induced negative emotions: Synergistic regulation of multiple brain regions	4
Seeing is believing: Identifying remyelination in the central nervous system	4
Towards development of disease-modifying therapy for Alzheimer's disease using redox chemical biology pathways	4
The changing landscape of the cystic fibrosis lung environment: From the perspective of Pseudomonas aeruginosa	4
Immune cell subtype contributions to doxorubicin cardiotoxicity–defining immune targets for translational interventions	4
Shaping surgical decisions in IBD — Unveiling the power of intestinal ultrasound across the perioperative pathway	4