BMC Medical Research Methodology

Article	Citations
The Preventiometer - reliability of a cardiovascular multi-device measurement platform and its measurement agreement with a cohort study	386
Assessment of the E-value in the presence of bias amplification: a simulation study	369
Understanding facilitators of research participation among adults with self-reported chronic pain – a survey examining hypothetical research participation	262
Tailored approach to participant recruitment and retention to maximize health equity in pediatric cancer research	210
Dynamic prediction based on variability of a longitudinal biomarker	162
Application of causal forests to randomised controlled trial data to identify heterogeneous treatment effects: a case study	152
Handling of missing component information for common composite score outcomes used in axial spondyloarthritis research when complete-case analysis is unbiased	150
A discrete-time split-state framework for multi-state modeling with application to describing the course of heart disease	108
A data-driven pipeline to extract potential adverse drug reactions through prescription, procedures and medical diagnoses analysis: application to a cohort study of 2,010 patients taking hydroxychloro	106
crossnma: An R package to synthesize cross-design evidence and cross-format data using network meta-analysis and network meta-regression	96
Do authors of systematic reviews of epidemiological observational studies assess the methodologies of the included primary studies? An empirical examination of methodological tool use in the literatur	96
Spatial data analysis of malnutrition among children under-five years in Ethiopia	81
Impact of different unconditional monetary incentives on survey response rates in men with prostate cancer: a 2-arm randomised trial	81
How likely is unmeasured confounding to explain meta-analysis-derived associations between alcohol, other substances, and mood-related conditions with HIV risk behaviors?	76
Poor reporting quality and high proportion of missing data in economic evaluations alongside pragmatic trials: a cross-sectional survey	76
A clinical phase I dose-finding design with adaptive shrinking boundaries for drug combination trials	74
Dementia risk prediction in individuals with mild cognitive impairment: a comparison of Cox regression and machine learning models	72
The Danish Drowning Cohort: Utstein-style data from fatal and non-fatal drowning incidents in Denmark	65
Adaptive designs in critical care trials: a simulation study	65
Standard of care for COVID-19 in randomized clinical trials registered in trial registries and published in preprint servers and scholarly journals: a cross-sectional study	64
Comparing statistical methods in assessing the prognostic effect of biomarker variability on time-to-event clinical outcomes	63
Investigating factors affecting the interval between a burn and the start of treatment using data mining methods and logistic regression	58
An improved method for the effect estimation of the intermediate event on the outcome based on the susceptible pre-identification	54
Comparison of statistical methods for the analysis of recurrent adverse events in the presence of non-proportional hazards and unobserved heterogeneity: a simulation study	53
Clinical research activities during COVID-19: the point of view of a promoter of academic clinical trials	53

Interactive molecular causal networks of hypertension using a fast machine learning algorithm MRdualPC	52
Methodological identification of anomalies episodes in ECG streams: a systematic mapping study	52
An investigation of the constancy of effect in Cochrane systematic reviews in context with the assumptions for noninferiority trials	50
Systematic review and meta analysis of differential attrition between active and control arms in randomized controlled trials of lifestyle interventions in chronic disease	50
Methodological assessment of systematic reviews of in-vitro dental studies	47
Neutral theory: applicability and neutrality of using generic health-related quality of life tools in diseases or conditions where specific tools are available	47
Comparison of reference distributions acquired by direct and indirect sampling techniques: exemplified with the Pediatric Reference Interval in China (PRINCE) study	44
Implementing multiple imputations for addressing missing data in multireader multicase design studies	43
Recruitment methods and yield rates in a clinical trial of physical exercise for older adults with hypertension—HAEL Study: a study within a trial	42
Evaluation of multiple imputation approaches for handling missing covariate information in a case-cohort study with a binary outcome	42
Reporting and communication of sample size calculations in adaptive clinical trials: a review of trial protocols and grant applications	42
Joint analysis of PK and immunogenicity outcomes using factorization model − a powerful approach for PK similarity study	40
Addressing misclassification bias in vaccine effectiveness studies with an application to Covid-19	40
Longitudinal mediation analysis with multilevel and latent growth models: a separable effects causal approach	39
Modular literature review: a novel systematic search and review method to support priority setting in health policy and practice	39
A gated group sequential design for seamless Phase II/III trial with subpopulation selection	39
Should multiple imputation be stratified by exposure group when estimating causal effects via outcome regression in observational studies?	39
Safety analysis of new medications in clinical trials: a simulation study to assess the differences between cause-specific and subdistribution frameworks in the presence of competing events	39
A spatial obesity risk score for describing the obesogenic environment using kernel density estimation: development and parameter variation	38
Simulation analysis of an adjusted gravity model for hospital admissions robust to incomplete data	37
Application of the multiple dependent state sampling strategy to late adolescent suicide rates	37
Construction of the Armenian Surname List (ASL) for public health research	36
Patient regional index: a new way to rank clinical specialties based on outpatient clinics big data	35
Raking of data from a large Australian cohort study improves generalisability of estimates of prevalence of health and behaviour characteristics and cancer incidence	35
IBIS: identify biomarker-based subgroups with a Bayesian enrichment design for targeted combination therapy	35
The INSPIRE Population Survey: development, dissemination and respondent characteristics	34
Sex-specific analysis of traumatic brain injury events: applying computational and data visualization techniques to inform prevention and management	32
Ripple effects mapping: capturing the wider impacts of systems change efforts in public health	32
Multiple states clustering analysis (MSCA), an unsupervised approach to multiple time-to-event electronic health records applied to multimorbidity associated with myocardial infarction	31
Designing tailored maintenance strategies for systematic reviews and clinical practice guidelines using the Portfolio Maintenance by Test-Treatment (POMBYTT) framework	31
Bayesian Mendelian randomization with an interval causal null hypothesis: ternary decision rules and loss function calibration	31
Comparison between asymptotic and re-randomisation tests under non-proportional hazards in a randomised controlled trial using the minimisation method	30
A doubly robust estimator for continuous treatments in high dimensions	30
External validation of the American prediction model for incident type 2 diabetes in the Iranian population	29
Central data monitoring in the multicentre randomised SafeBoosC-III trial – a pragmatic approach	29
Developing survey weights to ensure representativeness in a national, matched cohort study: results from the children and young people with Long Covid (CLoCk) study	28
Comparing current and emerging practice models for the extrapolation of survival data: a simulation study and case-study	28
The impact of different censoring methods for analyzing survival using real-world data with linked mortality information: a simulation study	28
CRIME-Q—a unifying tool for critical appraisal of methodological (technical) quality, quality of reporting and risk of bias in animal research	28
Are morbidity and mortality estimates from randomized controlled trials externally valid? A comparison of outcomes among infants enrolled into an RCT or a cohort study in Botswana	27
Statistical methods in the analysis of multicentre HIV randomized controlled trials in the African region: a scoping review	27
The validity, reliability and feasibility of four instruments for assessing the consciousness of stroke patients in a neurological intensive care unit compared	27
Bayesian mendelian randomization with study heterogeneity and data partitioning for large studies	27
Effects of different invitation strategies on participation in a cohort study of Iranian public sector employees: a cluster randomized trial	26
Reporting of interventional clinical trial results in an academic center: a survey of completed studies	26
Development of a diagnostic predictive model for determining child stunting in Malawi: a comparative analysis of variable selection approaches	25
External validation of existing dementia prediction models on observational health data	25
Recruitment into antibody prevalence studies: a randomized trial of postcards vs. letters as invitations	25
Predicting the presence of depressive symptoms in the HIV-HCV co-infected population in Canada using supervised machine learning	24
Modelling wound area in studies of wound healing interventions	24

Interpretable generalized neural additive models for mortality prediction of COVID-19 hospitalized patients in Hamadan, Iran	23
The use of sequential multiple assignment randomized trials (SMARTs) in physical activity interventions: a systematic review	22
Developing a dynamic simulation model to support the nationwide implementation of whole genome sequencing in lung cancer	22
Addressing treatment switching in the ALTA-1L trial with g-methods: exploring the impact of model specification	22
Classification of PR-positive and PR-negative subtypes in ER-positive and HER2-negative breast cancers based on pathway scores	22
Interchangeability and optimization of heart rate methods for estimating oxygen uptake in ergometer cycling, level treadmill walking and running	22
An ego-centred approach for the evaluation of spatial effects on health in urban areas based on parametric semi-variogram models: concept and validation	22
The reporting of prognostic prediction models for obstetric care was poor: a cross-sectional survey of 10-year publications	22
Functional data analysis to characterize disease patterns in frequent longitudinal data: application to bacterial vaginal microbiota patterns using weekly Nugent scores and identification of pattern-s	22
Accelerating evidence synthesis for safety assessment through ClinicalTrials.gov platform: a feasibility study	21
Ensuring cross-cultural data comparability by means of anchoring vignettes in heterogeneous refugee samples	21
Does imbalance in chest X-ray datasets produce biased deep learning approaches for COVID-19 screening?	21
The endorsement of general and artificial intelligence reporting guidelines in radiological journals: a meta-research study	20
Informed Bayesian survival analysis	20
Estimation of marginal structural models under irregular visits and unmeasured confounder: calibrated inverse probability weights	20
Predicting lung cancer survival prognosis based on the conditional survival bayesian network	19
Design and analysis of outcomes following SARS-CoV-2 infection in veterans	19
Technologies for frailty, comorbidity, and multimorbidity in older adults: a systematic review of research designs	19
Grouped data with survey revision	19
Weighted metrics are required when evaluating the performance of prediction models in nested case–control studies	18
Identification of difficult laryngoscopy using an optimized hybrid architecture	18
Mind the gap: covariate constrained randomisation can protect against substantial power loss in parallel cluster randomised trials	18
Toward value-based care using cost mining: cost aggregation and visualization across the entire colorectal cancer patient pathway	18
Prognostic score-based model averaging approach for propensity score estimation	17
Combining propensity score methods with variational autoencoders for generating synthetic data in presence of latent sub-groups	17
Reasons for missing evidence in rehabilitation meta-analyses: a cross-sectional meta-research study	17
Multiple imputation using auxiliary imputation variables that only predict missingness can increase bias due to data missing not at random	17
Application of the estimand framework for an emulated trial using reference based multiple imputation to investigate informative censoring	17
Adaptations for remote research work: a modified web-push strategy compared to a mail-only strategy for administering a survey of healthcare experiences	17
Comparing outcomes from tailored meta-analysis with outcomes from a setting specific test accuracy study using routine data of faecal calprotectin testing for inflammatory bowel disease	17
Tracking modifications to implementation strategies: a case study from SNaP - a hybrid type III randomized controlled trial to scale up integrated systems navigation and psychosocial counseling for PW	17
Evaluation of Bayesian spatiotemporal infectious disease models for prospective surveillance analysis	17
Robustness assessment of regressions using cluster analysis typologies: a bootstrap procedure with application in state sequence analysis	17
Comparative age-period-cohort analysis	16
Internal validation of self-reported case numbers in hospital quality reports: preparing secondary data for health services research	16
Advancing data science in drug development through an innovative computational framework for data sharing and statistical analysis	16
A compartmental model for smoking dynamics in Italy: a pipeline for inference, validation, and forecasting under hypothetical scenarios	16
coreSCD: multi-stakeholder consensus on core outcomes for sickle cell disease clinical trials	16
Evaluation of the Fill-it-up-design to use historical control data in randomized clinical trials with two arm parallel group design	16
Detecting the patient’s need for help with machine learning based on expressions	16
Frequency-based rare diagnoses as a novel and accessible approach for studying rare diseases in large datasets: a cross-sectional study	15
A framework to model global, regional, and national estimates of intimate partner violence	15
The analysis and reporting of multiple outcomes in mental health trials: a methodological systematic review	15
Growth mixture models: a case example of the longitudinal analysis of patient‐reported outcomes data captured by a clinical registry	15
regCOVID: Tracking publications of registered COVID-19 studies	15
How to specify healthcare process improvements collaboratively using rapid, remote consensus-building: a framework and a case study of its application	15
Classifying information-sharing methods	15
Group sequential designs for pragmatic clinical trials with early outcomes: methods and guidance for planning and implementation	15
Guidelines are needed for studies of pre-treatment HIV drug resistance: a methodological study	15
Effects of missing data imputation methods on univariate blood pressure time series data analysis and forecasting with ARIMA and LSTM	15
Neutral theory: applicability and neutrality of clinical study endpoints where a disease-specific instrument is available	15
Contextual effects: how to, and how not to, quantify them	14
Use of systems thinking and adapted group model building methods to understand patterns of technology use among older adults with type 1 diabetes: a preliminary process evaluation	14
Widening participation – recruitment methods in mental health randomised controlled trials: a qualitative study	14
Outcome risk model development for heterogeneity of treatment effect analyses: a comparison of non-parametric machine learning methods and semi-parametric statistical methods	14
CalScope: methodology and lessons learned for conducting a remote statewide SARS-CoV-2 seroprevalence study in California using an at-home dried blood spot collection kit and online survey	14
Modeling heart rate of individual and team manual handling with one hand using generalized additive mixed models	14
The iterative bisection procedure: a useful tool for determining parameter values in data-generating processes in Monte Carlo simulations	14
Multiple imputation to quantify misclassification in observational studies of the cognitively impaired: an application for pain assessment in nursing home residents	14
Better performance for right-skewed data using an alternative gamma model	14
Causal effect of chemotherapy received dose intensity on survival outcome: a retrospective study in osteosarcoma	14
MetaAnalyst: a user-friendly tool for metagenomic biomarker detection and phenotype classification	14
An evaluation of computational methods for aggregate data meta-analyses of diagnostic test accuracy studies	13
A new infodemiological approach through Google Trends: longitudinal analysis of COVID-19 scientific and infodemic names in Italy	13
Systematic reviews and meta-analysis published in indexed Portuguese medical journals: time trends and critical appraisal	13
Validation of HES coding for the detection of major bleeding events: insights from the ROBOT-ACS study	13
BivRec: an R package for the nonparametric and semiparametric analysis of bivariate alternating recurrent events	13
Research monitoring practices in critical care research: a survey of current state and attitudes	13
Risk prediction in multicentre studies when there is confounding by cluster or informative cluster size	13
Fast and optimal algorithm for case-control matching using registry data: application on the antibiotics use of colorectal cancer patients	13
Multistate Markov chain modeling for child undernutrition transitions in Ethiopia: a longitudinal data analysis, 2002–2016	12
Evaluating the current methodological practices and issues in existing literature in pooling complex surveys: a systematic review	12
Satisfaction and experience with colorectal cancer screening: a systematic review of validated patient reported outcome measures	12
Prediction of congenital heart disease for newborns: comparative analysis of Holt-Winters exponential smoothing and autoregressive integrated moving average models	12
Minimal important difference, patient acceptable symptom state and longitudinal validity of oxford elbow score and the quickDASH in patients with tennis elbow	12
Use and misuse of random forest variable importance metrics in medicine: demonstrations through incident stroke prediction	12
The effect of home visits as an additional recruitment step on the composition of the final sample: a cross-sectional analysis in two study centers of the German National Cohort (NAKO)	12
Motivations for enrollment in a COVID-19 ring-based post-exposure prophylaxis trial: qualitative examination of participant experiences	12
Flexible Bayesian semiparametric mixed-effects model for skewed longitudinal data	12
unmconf : an R package for Bayesian regression with unmeasured confounders	12

Concordance rate of a four-quadrant plot for repeated measurements	12
Towards realist-informed ripple effects mapping (RREM): positioning the approach	12
geessbin: an R package for analyzing small-sample binary data using modified generalized estimating equations with bias-adjusted covariance estimators	12
The optimal approach for retrieving systematic reviews was achieved when searching MEDLINE and Epistemonikos in addition to reference checking: a methodological validation study	12
Two-step spatiotemporal anomaly detection corrected for lag reporting time with application to real-time dengue surveillance in Thailand	12
External control arm analysis: an evaluation of propensity score approaches, G-computation, and doubly debiased machine learning	12
Comparative diagnostic accuracy studies with an imperfect reference standard – a comparison of correction methods	12
Data quality in an HIV vaccine efficacy clinical trial in South Africa: through natural disasters and with discipline	11
Improving patient clustering by incorporating structured variable label relationships in similarity measures	11
Clinical systematic reviews – a brief overview	11
Three new methodologies for calculating the effective sample size when performing population adjustment	11
Relationship between patient experience and hospital readmission: system-level survey with deterministic data linkage method	11
More than one third of clinical practice guidelines on low back pain overlap in AGREE II appraisals. Research wasted?	11
Correction: Multi‑arm multi‑stage (MAMS) randomised selection designs: impact of treatment selection rules on the operating characteristics	11
Analyzing missingness patterns in real-world data using the SMDI toolkit: application to a linked EHR-claims pharmacoepidemiology study	11
Machine learning in medicine: a practical introduction to natural language processing	11
From simple to even simpler, but not too simple: a head-to-head comparison of the Better-Worse and Drop-Down methods for measuring patient health status	11
Correction: Accounting for expected attrition in the planning of cluster randomized trials for assessing treatment effect heterogeneity	11
Outbreak detection algorithms based on generalized linear model: a review with new practical examples	11
A simple pooling method for variable selection in multiply imputed datasets outperformed complex methods	11
Applying a novel approach to scoping review incorporating artificial intelligence: mapping the natural history of gonorrhoea	11
A Bayesian network perspective on neonatal pneumonia in pregnant women with diabetes mellitus	11
Should RECOVERY have used response adaptive randomisation? Evidence from a simulation study	11
Correction to: A tutorial on pilot studies: the what, why and how	11
A scoping review of statistical methods in studies of biomarker-related treatment heterogeneity for breast cancer	11
Correction: Analysis of zero inflated dichotomous variables from a Bayesian perspective: application to occupational health	11
Correction: In health research publications, the number of authors is strongly associated with collective self-citations but less so with citations by others	11
Quality appraisal for systematic literature reviews of health state utility values: a descriptive analysis	10
A meta-review demonstrates improved reporting quality of qualitative reviews following the publication of COREQ- and ENTREQ-checklists, regardless of modest uptake	10
Methodology for the adolopment of recommendations for the treatment of rheumatoid arthritis in the Kingdom of Saudi Arabia	10
Predictive P-score for treatment ranking in Bayesian network meta-analysis	10
The proper application of logistic regression model in complex survey data: a systematic review	10
Time and change: a typology for presenting research findings in qualitative longitudinal research	10
Major mistakes or errors in the use of trial sequential analysis in systematic reviews or meta-analyses – the METSA systematic review	10
The role of the estimand framework in the analysis of patient-reported outcomes in single-arm trials: a case study in oncology	10
Making implementation science more real	10
Cluster randomised trials with a binary outcome and a small number of clusters: comparison of individual and cluster level analysis method	10
The impact of iterative removal of low-information cluster-period cells from a stepped wedge design	10
Test–retest reliability of selected HBSC items in Vietnam: well-being, physical and sedentary activities, and eating behaviours	10
How well did the consensus methods apply in the guideline development of traditional Chinese medicine: a web-based survey in China	10
The methodological quality assessment of systematic reviews/meta-analyses of chronic prostatitis/chronic pelvic pain syndrome using AMSTAR2	10
Gaps in the usage and reporting of multiple imputation for incomplete data: findings from a scoping review of observational studies addressing causal questions	10
Promoting data harmonization to evaluate vaccine hesitancy in LMICs: approach and applications	10
Evaluating complex interventions in context: systematic, meta-narrative review of case study approaches	10
Correction of vaccine effectiveness derived from test-negative case–control studies	10
FOUNTAIN: a modular research platform for integrated real-world evidence generation	10
Pre-statistical harmonization of behavioral instruments across eight surveys and trials	9
Application of machine learning in predicting hospital readmissions: a scoping review of the literature	9
Sample size requirements are not being considered in studies developing prediction models for binary outcomes: a systematic review	9
Correction: Real‑world data: a brief review of the methods, applications, challenges and opportunities	9
Inverse probability weighting to handle attrition in cohort studies: some guidance and a call for caution	9
Inference following multiple imputation for generalized additive models: an investigation of the median p-value rule with applications to the Pulmonary Hypertension Association Registry and Colorado C	9
Choices of measures of association affect the visualisation and composition of the multimorbidity networks	9
Understanding multimorbidity: insights with graphical models	9
Adjusting for outcome risk factors in immigrant datasets: total or direct effects?	9
Restrictions and their reporting in systematic reviews of effectiveness: an observational study	9
Power and sample size calculation for incremental net benefit in cost effectiveness analyses with applications to trials conducted by the Canadian Cancer Trials Group	9
Methodological aspects for accelerometer-based assessment of physical activity in heart failure and health	9
Use of research electronic data capture (REDCap) in a sequential multiple assignment randomized trial (SMART): a practical example of automating double randomization	9
Immortal time bias for life-long conditions in retrospective observational studies using electronic health records	9
What do stroke survivors’ value about participating in research and what are the most important research problems related to stroke or transient ischemic attack (TIA)? A survey	9
Comparison of prevalence and exposure-disease associations using self-report and hospitalization data among enrollees of the world trade center health registry	9
Similarities, reliability and gaps in assessing the quality of conduct of systematic reviews using AMSTAR-2 and ROBIS: systematic survey of nutrition reviews	9
A comparison of statistical methods for modeling count data with an application to hospital length of stay	9
Responsiveness of different pain measures and recall periods in people undergoing surgery after a period of splinting for basal thumb joint osteoarthritis	9
Open science saves lives: lessons from the COVID-19 pandemic	9
Interdisciplinary sport injury research and the integration of qualitative and quantitative data	9
Modelling of intensive care unit (ICU) length of stay as a quality measure: a problematic exercise	9
Constructing within and between hospital physician social networks for modeling physician research participation	9
Which test for crossing survival curves? A user’s guideline	9
Forecasting COVID-19 cases using time series modeling and association rule mining	9
The use of race and ethnicity in sickle cell disease research	8
Joint models for dynamic prediction in localised prostate cancer: a literature review	8
Joint modelling of multivariate longitudinal clinical laboratory safety outcomes, concomitant medication and clinical adverse events: application to artemisinin-based treatment during pregnancy clinic	8
Feature group partitioning: an approach for depression severity prediction with class balancing using machine learning algorithms	8
Quality of guidelines for infection management in sepsis: a critical appraisal using the AGREE II instrument	8
Binary classification with fuzzy logistic regression under class imbalance and complete separation in clinical studies	8
Bayesian additional evidence for decision making under small sample uncertainty	8
Arrhythmia detection by the graph convolution network and a proposed structure for communication between cardiac leads	8
Chi-square test under indeterminacy: an application using pulse count data	8
Enhancing insight into regional differences: hierarchical linear models in multiregional clinical trials	8
Estimating individualized treatment effects from randomized controlled trials: a simulation study to compare risk-based approaches	8
Investigator initiated trials versus industry sponsored trials - translation of randomized controlled trials into clinical practice (IMPACT)	8
Accounting for extent of non-compliance when estimating treatment effects on an ordinal outcome in randomized clinical trials	8
Problematic meta-analyses: Bayesian and frequentist perspectives on combining randomized controlled trials and non-randomized studies	8
Effect of alcohol consumption on breast cancer: probabilistic bias analysis for adjustment of exposure misclassification bias and confounders	8
Using group testing in a two-phase epidemiologic design to identify the effects of a large number of antibody reactions on disease risk	8
Evaluating methods to define place of residence in Canadian administrative data and the impact on observed associations with all-cause mortality in type 2 diabetes	8
Simple Excel and ICD-10 based dataset calculator for the Charlson and Elixhauser comorbidity indices	8
Discretizing multiple continuous predictors with U-shaped relationships with lnOR: introducing the recursive gradient scanning method in clinical and epidemiological research	8
In search of a ‘pan-European value set’; application for EQ-5D-3L	8
Integrating fractional-order SEI1I2I3QCR model with awareness and non-pharmaceutical interventions for optimal COVID-19 pandemic	8
A theoretical framework for linking hospitals longitudinally: demonstrated using German Hospital Quality Reports 2016–2020	8
An analysis of published study designs in PubMed prisoner health abstracts from 1963 to 2023: a text mining study	8
Case-only approach applied in environmental epidemiology: 2 examples of interaction effect using the US National Health and Nutrition Examination Survey (NHANES) datasets	8