OOIR: Observatory of International Research

Papers

(The TQCC of BMC Immunology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Incidence of severe adverse events in cancer patients after treatment with immune-checkpoint inhibitors during the COVID- 19 pandemic	71
SIRT5 affects lipid accumulation in cells of a metabolic-associated fatty liver disease model by regulating the succinylation status of HSPD1	62
Identification of potential characteristic genes in sepsis utilizing RNA sequencing and gene silence	60
The diagnostic value and validation of IL-22 combined with sCD40L in tuberculosis pleural effusion	36
Correlation analysis of positive Alzheimer’s disease plasma biological markers with plasma immune cell and clinical characteristics in mild cognitive impairment patients in China	30
Integrated bulk RNA sequencing and mass cytometry analysis reveal the circulating immune landscape in ischemic and hemorrhagic Moyamoya disease	27
Gentamicin promoted the production of CD4+CD25+ Tregs via the STAT5 signaling pathway in mice sepsis	21
A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons	21
Evaluating the predictive value of systemic inflammation indices in early pregnancy loss: a retrospective observational study	19
Clinical applications and diagnostic research of GFAP and NfL in MS and NMOSD: a meta-analysis	19
Prognostic significance of inflammatory cytokine polymorphisms in AML: a study of IFNG, TNFA, and IL1B polymorphisms	19
Clinical significance of miR-548a-3p and its potential role in acute respiratory distress syndrome complicated with pulmonary fibrosis via OSM	18
Sex differences exist in adult heart group 2 innate lymphoid cells	18
Interstitial lung diseases (ILD) in common variable immunodeficiency (CVID) patients: a study from Iran	17
Systematic evaluation of B-cell clonal family inference approaches	16
Saussurea involucrata oral liquid alleviates joint inflammation in CIA rats by modulating macrophage polarization and glucose metabolism	16
Histone acetylation risk model predicts prognosis and guides therapy selection in glioblastoma: implications for chemotherapy and anti-CTLA-4 immunotherapy	16
From immunity to identity to exaptation: RNA-based self/non-self discrimination across cellular life	14
CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8+ T cells	14
Platelet-derived extracellular vesicles promote endothelial dysfunction in sepsis by enhancing neutrophil extracellular traps	14
Potential role of IGF-1R in the interaction between orbital fibroblasts and B lymphocytes: an implication for B lymphocyte depletion in the active inflammatory phase of thyroid-associated ophthalmopat	14
In vitro characterization of cellular responses elicited by endosomal TLR agonists encapsulated in Qβ virus-like particles	13
Natural and induced immune responses in oral cavity and saliva	13
Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor	13
Variable clinical features and delayed diagnosis in six Chinese patients with anti-interferon-gamma autoantibodies: a retrospective analysis in a university hospital in China	12

Evaluation of immunoglobulin A1/immunoglobulin A2 ratio and B cell lymphoma-6 in relation to apoptosis-associated speck-like protein in diabetic kidney disease patients	12
Atypical skin conditions of the neck and back as a dermal manifestation of anti-HMGCR antibody-positive myopathy	12
FTO-mediated m6A demethylation of BECN1 mRNA promotes hepatic steatosis by impairing autophagy	12
Development and validation of a machine learning-based nomogram for predicting HLA-B27 expression	12
The decreased of peripheral blood natural killer cell is associated with serum IL-2 level in the renal tubular acidosis in patients with primary sjogren’s syndrome	11
The proportion and phenotypic changes of CD4+CD25−Foxp3+ T cells in patients with untreated rheumatoid arthritis	11
Correlation between peripheral blood Th17/Treg immune imbalance and coronary artery lesions in children with Kawasaki disease	10
Evaluation of the efficacy and safety of Iguratimod combined with traditional anti-rheumatic drugs in treating rheumatoid arthritis: a retrospective study	10
Evaluation of the effect of the COVID-19 pandemic on depression, anxiety and psychological resilience in patients with primary immunodeficiency	10
Treponema pallidum induces pathological injury of the rabbit testis and sperm through NLRP3 inflammasome activation-mediated pyroptosis	10
Phenotypic characterization of NK cells in 5-year-old children exposed to maternal HIV and antiretroviral therapy in early-life	10
The digestive system and autoimmunity	10
PU.1-CD23 signaling mediates pulmonary innate immunity against Aspergillus fumigatus infection by driving inflammatory response	10
IL-6 (-174 G/C) and IL-10 (-1082 G/A) polymorphisms and serum levels in Sudanese patients with end-stage renal disease and overt hepatitis B infection: a pilot comparative study	10
Clinical applications and methodology updates in HLA typing	9
The immune subtypes and landscape of sarcomas	9
The potential role of the gut microbiota in the development of autoantibodies associated with Spondyloarthritis: a narrative review	9
Investigation of KIR/HLA relationship and other clinical variables after T-cell-replete haploidentical bone marrow transplantation in patients with acute myeloid leukemia (AML)	9
Efficacy of the combination of antimicrobial therapy with immunomodulators in the management of immunological female infertility due to anti-sperm antibodies associated with bacterial vaginosis during	9
OmpA virulence factor, a promising conserved vaccine candidate against Acinetobacter baumannii, could trigger autoreactive immune responses in susceptible population	9
Markers of neutrophil activation and some immune and haematological indices in malaria infection during pregnancy	9
Identification of BTK as an immune-related biomarker for Hashimoto’s thyroiditis by integrated bioinformatic analysis	9
Deep analysis of the major histocompatibility complex genetic associations using covariate analysis and haploblocks unravels new mechanisms for the molecular etiology of Elite Control in AIDS	9
Oral administration of DNA alginate nanovaccine induced immune-protection against Helicobacter pylori in Balb/C mice	9
The efficacy analysis of immunotherapy rechallenge after progression from first-line chemo-immunotherapy in advanced non-small cell lung cancer	9
Pathogen exposure influences immune parameters around weaning in pigs reared in commercial farms	9
Analysis of risk factors of coronary artery lesions in Kawasaki disease and study of IVIG treatment response	9
Study on the value and mechanism of miR-369-5p in childhood pneumonia	9
Effect of immune-modulating metronomic capecitabine as an adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma	9
Autoimmune cytopenias in inborn errors of immunity: associations with monogenic mutations and immunologic parameters	9
Identification of four mitochondria-related genes in sepsis based on RNA sequencing technology	8
Correction: Thalidomide with blockade of costimulatory molecules prolongs the survival of alloantigen-primed mice with cardiac allografts	8
A quadral biosignature of IFN-γ, IL-2, IL-12 and IP-10 increases the diagnostic potential for latent tuberculosis among diabetic patients in Uganda	8
Dendrophenol modulates the LRRK1/PIK3AP1 signaling axis: a novel strategy to mitigate inflammation and pyroptosis in gouty arthritis	8
The correlation between the systemic immune-inflammation index and relapse and metastasis in cervical squamous cell carcinoma patients over 50 years and older	8
Profiling of T cell repertoire in peripheral blood of patients from type 2 diabetes with complication	8
Antagonist anti-LIF antibody derived from naive human scFv phage library inhibited tumor growth in mice	8
Efficiency of bone marrow-derived cells in the treatment of experimental autoimmune type 1 diabetes: immunomodulatory and anti-apoptotic properties	8
Autoimmunity’s enigmatic role: exploring the connection with myalgic encephalomyelitis/chronic fatigue syndrome	8
Intervention effect of curcumin on sepsis-associated acute kidney injury via regulation of p300 expression and protein lactylation	8
Pidotimod alleviated experimental autoimmune encephalomyelitis by regulating the balance of splenic lymphocytes	8
Evaluation of Th1-Th2 balance in patients with recurrent implantation failure; a systematic review and meta-analysis	7
Patients with indolent lymphomas are at high risk of infections: experience from a German outpatient clinic	7
Zinc as a therapeutic adjunct: enhancing t-cell reconstitution in hematopoietic stem cell transplant recipients—a double-blind clinical study	7
Investigation and characteristics of 115 cases with unexpected antibodies for improving transfusion strategies: a retrospective study	7
The predictive value of peripheral blood monocytic myeloid-derived suppressor cells for survival and immunotherapy responses in tumor patients	7
Efficacy and safety of Depemokimab in asthma with eosinophilic phenotype: a systematic review and meta-analysis of randomized controlled trials	7
Identification of characteristic genes of pressure ulcers based on angiogenesis-related genes and construction of miRNA, transcription factor, and molecular drug regulatory networks	7
Bcl-3 regulates T cell function through energy metabolism	7
Proinflammatory plasticity towards Th17 paradigm of regulatory T cells consistent with elevated prevalence of TGFBR2 variants in elderly patients with primary immune thrombocytopenia	7

Neutralizing antibody responses assessment after vaccination in people living with HIV using a surrogate neutralization assay	7
Optimized workflow to modify microRNA expression in primary human intravascular cells	7
Unsolved mystery of Fas: mononuclear cells may have trouble dying in patients with Sjögren’s syndrome	7
The exhaustion of lymphocytes is the main factor that decreases the sensitivity of QFT-GIT detection in silicosis	7
Decreased frequency of Th22 cells and IL-22 cytokine in kidney transplant patients with active cytomegalovirus infection	7
Pretreatment immunoglobulin profiles and survival outcomes in hematologic malignancies and autoimmune cytopenias: a comparative cohort analysis	7
Efficacy of probiotics on immunological and clinical outcomes in allergic rhinitis: an umbrella review and updated meta-analysis of RCTs in children and adults	7
Methionine enkephalin(MENK) upregulated memory T cells in anti-influenza response	7
RETRACTED ARTICLE: Tumor microenvironment and immune system preservation in early-stage breast cancer: routes for early recurrence after mastectomy and treatment for lobular and ductal forms of diseas	7
Expression of the immune checkpoint molecules CD226 and TIGIT in preeclampsia patients	6
Transcriptomic responses of bat cells to European bat lyssavirus 1 infection under conditions simulating euthermia and hibernation	6
NLRP3 inflammasome up-regulates major histocompatibility complex class I expression and promotes inflammatory infiltration in polymyositis	6
Putative novel outer membrane antigens multi-epitope DNA vaccine candidates identified by Immunoinformatic approaches to control Acinetobacter baumannii	6
Brucellosis novel multi-epitope vaccine design based on in silico analysis focusing on Brucella abortus	6
Parameter analysis of an ovalbumin combined with aluminum hydroxide adjuvant-induced allergic rhinitis model in BALB/c mice: a systematic review and meta-analysis	6
Clinical and immunological factors associated with gastrointestinal involvement in common variable immunodeficiency: a real-world study	6
Hyperactivation and enhanced cytotoxicity of reduced CD8+ gamma delta T cells in the intestine of patients with Crohn’s disease correlates with disease activity	6
Establishment of age-specific reference intervals for peripheral blood SII, NLR, PLR, and LMR in healthy children	6
Chlorogenic acid mitigates ferroptosis in macrophages induced by pneumolysin and streptococcus pneumoniae through activation of NRF2/GPX4 pathway	6
Expanding the clinical spectrum of Cernunnos/XLF deficiency: a literature review of a rare cause of severe combined immunodeficiency including a novel case	6
Expression and clinical significance of plasma microRNA-155 in patients with primary Sjögren’s disease	6
Potential causes and associated conditions with anti-sperm antibody production among infertile males: a systematic literature review	6
The association of peripheral blood inflammatory markers with the distribution patterns of IgE in children with allergen sensitization	6
Advances in the Understanding of ocular and nasal lymphatics	6
Complete Complement Factor I (CFI) deficiency: a systematic review of forty-nine patients including three novel cases	6
Active tuberculosis disease in pregnancy alters frequencies of B-cell subsets among exposed neonates in Uganda	6
The immune factors have complex causal regulation effects on kidney stone disease: a mendelian randomization study	6
Systematic literature reviews to identify epidemiological, clinical, economic and health-related quality of life evidence in activated PI3Kδ syndrome (APDS)	6
Putative new combination vaccine candidates identified by reverse vaccinology and genomic approaches to control enteric pathogens	6
Elevated serum TNF-α in patients with immune-mediated necrotizing myopathy correlates with muscle damage	6
PRMT2 silencing regulates macrophage polarization through activation of STAT1 or inhibition of STAT6	6
mTORC2 is crucial for regulating the recombinant Mycobacterium tuberculosis CFP-10 protein-induced phagocytosis in macrophages	6
Inhibition of CEACAM1 expression in cytokine-activated neutrophils using JAK inhibitors	6
Association of the systemic immune-inflammation index with clinical outcomes in acute myocardial infarction patients with hypertension	6