OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Molecular Cell Biology is 61. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
The translation m(o)TOR that propels regeneration	2395
When senescence generates pluripotent stem cells	1344
Transfection reflections: fit-for-purpose delivery of nucleic acids	1320
A dynamic culture system that models the intricacy of the mammary gland	1310
From trans-splicing discovery and onwards, trypanosomes lead the way	1105
Re-sizing of nuclear pores	1020
Histone H1 deamidation regulates DNA double-strand break repair	812
Tightening the epithelium to control signalling	811
Modulation of cellular processes by histone and non-histone protein acetylation	805
Understanding mechanisms of antioxidant action in health and disease	630
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	621
DNA-repair-driven cell death compels us to rethink cancer therapies	579
Mechanisms of substrate processing during ER-associated protein degradation	561
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	551
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	504
Publisher Correction: Plant hormone regulation of abiotic stress responses	499
Resilience through selective translation	454
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	419
How proteins sense their cellular environment	410
N-glycan-dependent protein maturation and quality control in the ER	384
Decoding the Ca2+ signal for salt tolerance	381
New insights into activation and function of the AMPK	369
Mechanism and regulation of kinesin motors	362
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	360
The emerging mechanisms and functions of microautophagy	357

The healing role of gasdermin B in IBD	346
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	344
Mechanisms and roles of podosomes and invadopodia	339
C-degron mimicry confers E3 ligase selectivity	335
Bookmarking pluripotency genes	320
Silencing centromeres with age	317
Voices of the new generation: open science is good for science (and for you)	314
The discovery of oncogene-induced senescence	309
Nucleosomes as blueprints of genome architecture	301
Studying lysosomal function and dysfunction using LysoIP	300
Regulation, functions and transmission of bivalent chromatin during mammalian development	299
CRISPR–Cas applications in agriculture and plant research	296
Biology and therapeutic targeting of vascular endothelial growth factor A	294
Telomere function and regulation from mouse models to human ageing and disease	291
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design	284
Regulation of membrane protein structure and function by their lipid nano-environment	281
Curvature-mediated endocytosis	263
Big cells, small potential	253
Molecular tools for analysing in vivo senescence	252
A quick guide to (transmembrane) planar cell polarity mouse strains	248
The RNA world ‘hypothesis’	239
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	223
Migrasomes promote angiogenesis	222
Improving chemical reprogramming strategies	221
The prospects and opportunities of protein structure prediction with AI	215
Why novel mRNA modifications are so challenging and what we can do about it	214
FOXO transcription factors as mediators of stress adaptation	213
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	208
Circadian clock communication during homeostasis and ageing	204
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	203
Science Twitter — navigating change in science communication	201
Context-dependent TGFβ family signalling in cell fate regulation	200
Molecular mechanisms and consequences of mitochondrial permeability transition	188
Splicing regulation through biomolecular condensates and membraneless organelles	179
RNA binding — a useful third wheel in transcription	174
Transposons: catch them if you can	174
Mechanisms of mitochondrial respiratory adaptation	170
New tool for MAPping microtubule dynamics	170
Activation of human endogenous retroviruses and its physiological consequences	168
Energy-driven genome regulation by ATP-dependent chromatin remodellers	167
Context-specific regulation and function of mRNA alternative polyadenylation	167
Does species-specific alternative splicing make us human?	160
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	159
Regulation and function of insulin and insulin-like growth factor receptor signalling	157
How ancient RNA survives and what we can learn from it	157
Transcriptional control of energy metabolism by nuclear receptors	149
Apical–basal polarity and the control of epithelial form and function	146
Molecular machineries and pathways of mitochondrial protein transport	145
Revisiting small RNA movement in plants	143
Targeted protein degradation: from mechanisms to clinic	141

Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	141
A guide to cell death pathways	140
Myosin VI assists in fork protection	139
Cold-induced longevity through proteasome boosting	131
New frontiers in quality control: the case of GPI-anchored proteins	128
The centromere as a tag of self-DNA	125
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	122
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	120
The technological landscape and applications of single-cell multi-omics	119
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	119
The molecular basis for cellular function of intrinsically disordered protein regions	118
DEI conversations: more than a box-ticking exercise	117
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	112
Fat cells have long-lasting (epigenetic) memory	108
Genome characteristics at the borders	105
ATP and ROS signal cell extrusion	101
Anticancer effects of zotatifin are mediated by RNA structure remodelling	96
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	94
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	92
Microenvironmental determinants of endothelial cell heterogeneity	92
Nuclear compartmentalization as a mechanism of quantitative control of gene expression	91
The role and regulation of integrins in cell migration and invasion	90
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	90
Mechanisms of microtubule organization in differentiated animal cells	88
Interplay between mechanics and signalling in regulating cell fate	86
Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition	85
Sleep tight thanks to Parp1	81
Deep learning shapes single-cell data analysis	81
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	81
Unravelling oocyte ultrastructure	79
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	79
Ethylene — the lifeguard hormone	79
From shortening telomeres to replicative crisis	78
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	78
Transcription factors crossing the cell membrane	75
The contribution of databases towards understanding the universe of long non-coding RNAs	75
Profiling the disordered proteome in cells using a chemical tag	73
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	72
How green is your science? The race to make laboratories sustainable	72
The many regulators of epithelial−mesenchymal transition	70
Mechanisms and regulation of substrate degradation by the 26S proteasome	68
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	65
The molecular principles of gene regulation by Polycomb repressive complexes	63
Exercise metabolism and adaptation in skeletal muscle	63
Karyopherin-mediated nucleocytoplasmic transport	61