OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Molecular Cell Biology is 37. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
A Tour de force of primary cilium biogenesis	1984
Solving the Wnt nuclear puzzle	962
Epithelia arm up for dead-cell clearance	899
Cytokinin receptor turns 20	824
Sequencing technologies to measure translation in single cells	806
Epigenetic discovery by enzyme activity profiling	762
The centromere as a tag of self-DNA	605
From organism behaviour to molecular mechanisms	536
The translation m(o)TOR that propels regeneration	445
MYC in TOP shape	411
Cold-induced longevity through proteasome boosting	410
Has translation in the nucleus found its purpose?	402
Tau oligomers are linked to m6A-RNA	377
Anoikis resistance through blebs	371
Cell quiescence sends argonaute-2 to transposons	345
Smelling your way to longevity	342
Genome doubling — twice the same is not the same	329
Myosin VI assists in fork protection	328
Regulation of cellular and systemic sphingolipid homeostasis	313
From trans-splicing discovery and onwards, trypanosomes lead the way	306
Chaperoning solid aggregates for autophagy	298
The neuronal epigenome is special	296
The discovery of simple repeats that cause complex disorders	283
Mechanisms of substrate processing during ER-associated protein degradation	277
Tightening the epithelium to control signalling	261

Internal-m7G-modified mRNAs quake under stress	261
Senescent cells support limb regeneration	252
Re-sizing of nuclear pores	248
Die hard: resilient RNAs in the blood	238
RNF26 and vimentin orchestrate ER stress recovery	233
Mechanism of sperm mtDNA elimination	231
New frontiers in quality control: the case of GPI-anchored proteins	222
Targeting viruses in their phase	219
A dynamic culture system that models the intricacy of the mammary gland	219
Identification of metabolic networks by genetic co-essentiality analysis	218
Modelling tauopathies	216
New guidelines for embryo and stem cell research	213
m6A ‘encodes’ a dedicated mRNA decay pathway	212
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization	208
Lasker Award for AlphaFold	207
Transitioning through the continuum of differentiation	198
Mechanisms and functions of protein S-acylation	195
Transfection reflections: fit-for-purpose delivery of nucleic acids	195
Mechanisms underlying spindle assembly and robustness	188
Sorting membrane proteins by size in the Golgi	187
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	186
Cell cycle control in cancer	181
Long non-coding RNAs: definitions, functions, challenges and recommendations	179
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	179
Mechanisms and pathology of protein misfolding and aggregation	178
Plant hormone regulation of abiotic stress responses	178
Mechanisms controlling cellular and systemic iron homeostasis	171
Selective motor activation in organelle transport along axons	170
Heterochromatin definition and function	163
The technological landscape and applications of single-cell multi-omics	157
Understanding mechanisms of antioxidant action in health and disease	149
The assembly, regulation and function of the mitochondrial respiratory chain	146
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	146
The molecular basis for cellular function of intrinsically disordered protein regions	145
The cell biology of ferroptosis	144
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	143
White adipocyte dysfunction and obesity-associated pathologies in humans	143
Dicing viral RNA in stem cells	141
The aetiology and molecular landscape of insulin resistance	141
Biochemical and mechanical regulation of actin dynamics	139
Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer	135
Publisher Correction: Translating the midbody for cytokinesis	131
Publisher Correction: White adipocyte dysfunction and obesity-associated pathologies in humans	127
Author Correction: Molecular mechanisms underlying nucleotide repeat expansion disorders	127
Modulation of cellular processes by histone and non-histone protein acetylation	124
Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions	123
IL-11 as a master regulator of ageing	119
When senescence generates pluripotent stem cells	115
In memoriam Judy Campisi: spreading cellular senescence	114
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	110

Publisher Correction: Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization	109
Molecular mechanisms underlying nucleotide repeat expansion disorders	107
The multiple links between actin and mitochondria	106
Phosphoinositides as membrane organizers	103
Let’s talk about (biological) sex	100
A lncRNA builds a glycolytic metabolon	98
CTCF works better under tension	95
A SOX9 switch from regeneration to fibrosis	95
Cracking genetic codes of longevity	94
Far from the cytoplasmic crowd	91
Phase separation of biomolecules on free-standing planar membranes	90
The nuance in DNA and transcription factor interactions	88
STINGing through the membrane to channel protons	85
DEI conversations: more than a box-ticking exercise	85
Resilience through selective translation	83
RNA-mediated (de)condensation	80
Making more exosomes	77
The birth of stable introns	74
Intermittent fasting is gaining interest fast	73
Decoding the Ca2+ signal for salt tolerance	70
Control of satellite cell function in muscle regeneration and its disruption in ageing	66
Plant and animal small RNA communications between cells and organisms	65
Transcriptional networks controlling stromal cell differentiation	64
Cellular and molecular mechanisms of skin wound healing	64
Fundamentals of redox regulation in biology	58
Structure and growth of plant cell walls	57
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	57
Structural biology and molecular pharmacology of voltage-gated ion channels	56
Mitochondrial ROS drive cell cycle progression	56
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics	56
Miniaturizing Cas	55
Is amyloid-β a friend or foe?	54
Early insights into co-translational assembly of protein complexes	53
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	52
Mending broken hearts with the help of epigenetic remodellers	52
ATP and ROS signal cell extrusion	52
Cytosol-to-nucleus journey of a novel histone PTM	51
Who did what: changing how science papers are written to detail author contributions	46
Size matters	46
A code within the genetic code	44
Damaged mitochondria are discarded via migrasomes	44
Endocytosis in the context-dependent regulation of individual and collective cell properties	43
The cellular and functional complexity of thermogenic fat	43
New insights into activation and function of the AMPK	42
A guide to membraneless organelles and their various roles in gene regulation	41
The physiology of alternative splicing	40
Genome characteristics at the borders	38
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	38
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	37
RNA polymerase II transcription compartments: from multivalent chromatin binding to liquid droplet formation?	37
Localized translation in the embryo	37
Engineering cellular symphonies out of transcriptional noise	37
‘Poisoning’ of the transcriptome by ultraconserved elements	37