OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Molecular Cell Biology is 44. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
Ferroptosis: mechanisms, biology and role in disease	2613
Gene regulation by long non-coding RNAs and its biological functions	2531
Mechanisms of SARS-CoV-2 entry into cells	1686
Human organoids: model systems for human biology and medicine	1159
Cellular senescence in ageing: from mechanisms to therapeutic opportunities	934
A guide to machine learning for biologists	735
Reactive oxygen species signalling in plant stress responses	664
NAD+ metabolism and its roles in cellular processes during ageing	657
Global view of human protein glycosylation pathways and functions	620
Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing	608
Cell cycle control in cancer	607
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology	584
The nucleolus as a multiphase liquid condensate	532
Emerging connectivity of programmed cell death pathways and its physiological implications	512
Mechanisms of bone development and repair	506
Long non-coding RNAs: definitions, functions, challenges and recommendations	490
A framework for understanding the functions of biomolecular condensates across scales	489
Challenges and directions in studying cell–cell communication by extracellular vesicles	456
Applications of CRISPR–Cas in agriculture and plant biotechnology	456
RNA contributions to the form and function of biomolecular condensates	376
Plant hormone regulation of abiotic stress responses	371
Cell fate specification and differentiation in the adult mammalian intestine	335
The expanding world of tRNA modifications and their disease relevance	328
The assembly, regulation and function of the mitochondrial respiratory chain	327
Molecular mechanisms of dietary restriction promoting health and longevity	316

Mechanisms controlling pancreatic islet cell function in insulin secretion	301
Genome folding through loop extrusion by SMC complexes	298
The principles of directed cell migration	298
Modulation of cellular processes by histone and non-histone protein acetylation	288
Diversity and versatility of p38 kinase signalling in health and disease	283
The mechanisms and roles of selective autophagy in mammals	269
The aetiology and molecular landscape of insulin resistance	265
Machinery, regulation and pathophysiological implications of autophagosome maturation	258
Quality control of the mitochondrial proteome	255
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design	240
The molecular basis and disease relevance of non-homologous DNA end joining	239
The roles of histone variants in fine-tuning chromatin organization and function	237
The molecular principles of gene regulation by Polycomb repressive complexes	234
The cellular and functional complexity of thermogenic fat	232
The roles of Polycomb repressive complexes in mammalian development and cancer	226
Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression	223
The plasticity of DNA replication forks in response to clinically relevant genotoxic stress	216
Crosstalk between mechanotransduction and metabolism	214
New insights into activation and function of the AMPK	211
Understanding 3D genome organization by multidisciplinary methods	210
Molecular mechanisms and consequences of mitochondrial permeability transition	210
Autophagy and autophagy-related pathways in cancer	203
Direct cell reprogramming: approaches, mechanisms and progress	193
Mechanisms and regulation of protein synthesis in mitochondria	190
Intracellular mRNA transport and localized translation	187
Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	181
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	178
MicroRNA-mediated regulation of glucose and lipid metabolism	176
Molecular mechanisms underlying nucleotide repeat expansion disorders	176
Programmed and self-organized flow of information during morphogenesis	173
Regulation of membrane protein structure and function by their lipid nano-environment	171
Roles of transposable elements in the regulation of mammalian transcription	170
Control of satellite cell function in muscle regeneration and its disruption in ageing	167
Mechanics and functional consequences of nuclear deformations	161
Context-specific regulation of extracellular vesicle biogenesis and cargo selection	160
Human topoisomerases and their roles in genome stability and organization	154
Cellular origins of dsRNA, their recognition and consequences	152
Nuclear compartmentalization as a mechanism of quantitative control of gene expression	150
Phosphoinositides as membrane organizers	145
Regulation of microtubule dynamics, mechanics and function through the growing tip	143
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization	143
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	140
The technological landscape and applications of single-cell multi-omics	140
Causes and consequences of RNA polymerase II stalling during transcript elongation	138
A guide to membraneless organelles and their various roles in gene regulation	135
Liver regeneration and inflammation: from fundamental science to clinical applications	134
The emerging mechanisms and functions of microautophagy	132
The physiology of alternative splicing	130
Signalling mechanisms and cellular functions of SUMO	126
Karyopherin-mediated nucleocytoplasmic transport	125

Cell–extracellular matrix mechanotransduction in 3D	123
Cellular functions of the protein kinase ATM and their relevance to human disease	120
The mechanisms of integral membrane protein biogenesis	119
Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions	119
Pioneer factors as master regulators of the epigenome and cell fate	117
Apical–basal polarity and the control of epithelial form and function	114
An expanded lexicon for the ubiquitin code	114
Ageing and rejuvenation of tissue stem cells and their niches	111
Context-specific regulation and function of mRNA alternative polyadenylation	109
Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining	103
Biochemical and mechanical regulation of actin dynamics	103
Gene regulation in time and space during X-chromosome inactivation	101
Roles of RNA silencing in viral and non-viral plant immunity and in the crosstalk between disease resistance systems	97
The Mediator complex as a master regulator of transcription by RNA polymerase II	92
Interplay between mechanics and signalling in regulating cell fate	90
Mechanisms of BCL-2 family proteins in mitochondrial apoptosis	86
Emerging roles and functional mechanisms of PIWI-interacting RNAs	84
Plant and animal small RNA communications between cells and organisms	83
Metabolites as signalling molecules	83
Mechanisms of mitochondrial respiratory adaptation	80
Mechanisms controlling cellular and systemic iron homeostasis	78
Translational control of stem cell function	75
Mechanisms of microtubule organization in differentiated animal cells	74
Selective motor activation in organelle transport along axons	74
Principles and dynamics of spindle assembly checkpoint signalling	74
Cell–cell interfaces as specialized compartments directing cell function	72
Regulation, functions and transmission of bivalent chromatin during mammalian development	71
Ubiquitin ligases: guardians of mammalian development	71
Endocytosis in the context-dependent regulation of individual and collective cell properties	65
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	65
Regulation of axonal regeneration after mammalian spinal cord injury	65
Author Correction: Gene regulation by long non-coding RNAs and its biological functions	63
Spindle positioning and its impact on vertebrate tissue architecture and cell fate	63
Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins	63
Molecular and cellular basis of genetically inherited skeletal muscle disorders	62
The molecular basis for cellular function of intrinsically disordered protein regions	62
Acquired genetic changes in human pluripotent stem cells: origins and consequences	60
Mechanisms and roles of podosomes and invadopodia	57
COVID-19 management in light of the circadian clock	53
Regulation and functions of non-m6A mRNA modifications	52
Biology and therapeutic targeting of vascular endothelial growth factor A	52
Transcriptional control of energy metabolism by nuclear receptors	52
Mechanical regulation of early vertebrate embryogenesis	52
Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases	51
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	50
Effects of aneuploidy on cell behaviour and function	44
Aneuploidy in mammalian oocytes and the impact of maternal ageing	44
Deep learning shapes single-cell data analysis	44