OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Molecular Cell Biology is 45. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
When senescence generates pluripotent stem cells	2077
Tightening the epithelium to control signalling	2003
Histone H1 deamidation regulates DNA double-strand break repair	1266
The secretory pathway gets a molecular framework	1244
A dynamic culture system that models the intricacy of the mammary gland	1130
Advancing single-cell omics and cell-based therapeutics with quantum computing	907
Transfection reflections: fit-for-purpose delivery of nucleic acids	893
DNA-repair-driven cell death compels us to rethink cancer therapies	866
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	759
The translation m(o)TOR that propels regeneration	668
Mechanisms of substrate processing during ER-associated protein degradation	664
Understanding mechanisms of antioxidant action in health and disease	654
Decoding the Ca2+ signal for salt tolerance	645
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	645
The double life of a transcription factor in the cytoplasm	575
Chemical reprogramming of human blood cells	520
Resilience through selective translation	517
The advent of confocal laser scanning microscopy in biological research	512
Programmed ‘DNA splicing’ removes transposons from genes	501
Progress in stem cell-based embryo models and their applications in developmental biology and biomedicine	473
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	445
PIONEARing how DNA sequence composition tunes TF–nucleosome interactions	404
How proteins sense their cellular environment	404
Engineered nanobodies facilitate cryo-EM studies of small proteins	384
Mechanism and regulation of kinesin motors	377

N-glycan-dependent protein maturation and quality control in the ER	338
New insights into activation and function of the AMPK	334
The emerging mechanisms and functions of microautophagy	333
C-degron mimicry confers E3 ligase selectivity	328
Nucleosomes as blueprints of genome architecture	312
Telomere function and regulation from mouse models to human ageing and disease	303
The discovery of oncogene-induced senescence	303
Silencing centromeres with age	294
Bookmarking pluripotency genes	293
Coordination of cardiogenesis in vivo and in vitro	288
DNA looping regulates transcription	285
Studying lysosomal function and dysfunction using LysoIP	284
CRISPR–Cas applications in agriculture and plant research	283
Biology and therapeutic potential of extracellular vesicle targeting and uptake	260
ESCRT-III function in membrane fission and repair	257
Regulation, functions and transmission of bivalent chromatin during mammalian development	257
Regulation of membrane protein structure and function by their lipid nano-environment	254
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	250
Biology and therapeutic targeting of vascular endothelial growth factor A	245
Mechanisms and roles of podosomes and invadopodia	237
Molecular tools for analysing in vivo senescence	227
A quick guide to (transmembrane) planar cell polarity mouse strains	224
Snoozing APC/C for a sweet cell cycle entry	223
A histone variant that manages abiotic stress in plants	222
Migrasomes promote angiogenesis	216
Science Twitter — navigating change in science communication	211
The RNA world ‘hypothesis’	210
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	201
Improving chemical reprogramming strategies	199
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	197
Context-dependent TGFβ family signalling in cell fate regulation	185
Circadian clock communication during homeostasis and ageing	183
FOXO transcription factors as mediators of stress adaptation	183
Splicing regulation through biomolecular condensates and membraneless organelles	182
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	177
RNA binding — a useful third wheel in transcription	176
Like water on rock, the microenvironment bends stem cell fate	174
Mechanisms and regulation of the Hsp70 chaperone network	169
Energy-driven genome regulation by ATP-dependent chromatin remodellers	169
Subcellular localization as a driver of protein function	168
Mechanisms of mitochondrial respiratory adaptation	164
Context-specific regulation and function of mRNA alternative polyadenylation	157
Activation of human endogenous retroviruses and its physiological consequences	156
Does species-specific alternative splicing make us human?	150
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	147
How ancient RNA survives and what we can learn from it	138
Organelles stick together through PDZD8-mediated condensate formation	138
Molecular machineries and pathways of mitochondrial protein transport	137
Regulation and function of insulin and insulin-like growth factor receptor signalling	136
Targeted protein degradation: from mechanisms to clinic	130

Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	127
A guide to cell death pathways	125
Myosin VI assists in fork protection	124
The centromere as a tag of self-DNA	123
Cold-induced longevity through proteasome boosting	119
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	113
Decoding ubiquitin signals inside cells	109
Redox-driven cell death by disulfidptosis and its therapeutic potential	107
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	104
New frontiers in quality control: the case of GPI-anchored proteins	103
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	101
The molecular basis for cellular function of intrinsically disordered protein regions	100
DEI conversations: more than a box-ticking exercise	97
The technological landscape and applications of single-cell multi-omics	97
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	96
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	95
Anticancer effects of zotatifin are mediated by RNA structure remodelling	94
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	94
Genome characteristics at the borders	94
Fat cells have long-lasting (epigenetic) memory	91
New developments and applications of human organoids	90
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	85
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	85
Microenvironmental determinants of endothelial cell heterogeneity	83
The role and regulation of integrins in cell migration and invasion	82
Unravelling oocyte ultrastructure	81
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	80
Profiling the disordered proteome in cells using a chemical tag	79
Transcription factors crossing the cell membrane	79
The contribution of databases towards understanding the universe of long non-coding RNAs	77
From shortening telomeres to replicative crisis	75
The hunter becomes the hunted in target-directed microRNA degradation	73
How green is your science? The race to make laboratories sustainable	73
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	69
Ethylene — the lifeguard hormone	68
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	67
Neural crest gene regulatory networks as drivers of development, diversification and disease	66
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	66
Exercise metabolism and adaptation in skeletal muscle	65
Mechanisms and regulation of substrate degradation by the 26S proteasome	58
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	56
Cellular role of TETs in early embryos	52
Publisher Correction: Advancing single-cell omics and cell-based therapeutics with quantum computing	48
Translation feedback control in the brain	48
Cis-regulatory elements that tune transcriptional responses in liver drug metabolism and outcomes	46
Following the electric current	45