OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Molecular Cell Biology is 44. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Ferroptosis: mechanisms, biology and role in disease	3069
Gene regulation by long non-coding RNAs and its biological functions	2757
Mechanisms of SARS-CoV-2 entry into cells	1853
Cellular senescence in ageing: from mechanisms to therapeutic opportunities	1040
A guide to machine learning for biologists	856
Reactive oxygen species signalling in plant stress responses	773
NAD+ metabolism and its roles in cellular processes during ageing	719
Long non-coding RNAs: definitions, functions, challenges and recommendations	693
Cell cycle control in cancer	687
Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing	679
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology	676
A framework for understanding the functions of biomolecular condensates across scales	537
Challenges and directions in studying cell–cell communication by extracellular vesicles	527
Plant hormone regulation of abiotic stress responses	464
The assembly, regulation and function of the mitochondrial respiratory chain	386
The expanding world of tRNA modifications and their disease relevance	371
The principles of directed cell migration	345
Molecular mechanisms of dietary restriction promoting health and longevity	345
Modulation of cellular processes by histone and non-histone protein acetylation	344
The mechanisms and roles of selective autophagy in mammals	338
Genome folding through loop extrusion by SMC complexes	328
Mechanisms controlling pancreatic islet cell function in insulin secretion	327
Diversity and versatility of p38 kinase signalling in health and disease	315
Autophagy and autophagy-related pathways in cancer	305
The aetiology and molecular landscape of insulin resistance	301

Machinery, regulation and pathophysiological implications of autophagosome maturation	284
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design	278
New insights into activation and function of the AMPK	264
The cellular and functional complexity of thermogenic fat	261
The molecular principles of gene regulation by Polycomb repressive complexes	256
Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression	247
Molecular mechanisms and consequences of mitochondrial permeability transition	243
The roles of Polycomb repressive complexes in mammalian development and cancer	238
Understanding 3D genome organization by multidisciplinary methods	232
Crosstalk between mechanotransduction and metabolism	230
Direct cell reprogramming: approaches, mechanisms and progress	214
Mechanisms and regulation of protein synthesis in mitochondria	210
Context-specific regulation of extracellular vesicle biogenesis and cargo selection	210
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	204
Regulation of membrane protein structure and function by their lipid nano-environment	200
Intracellular mRNA transport and localized translation	199
The technological landscape and applications of single-cell multi-omics	198
Roles of transposable elements in the regulation of mammalian transcription	197
MicroRNA-mediated regulation of glucose and lipid metabolism	195
Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	195
Molecular mechanisms underlying nucleotide repeat expansion disorders	194
Cellular origins of dsRNA, their recognition and consequences	186
Control of satellite cell function in muscle regeneration and its disruption in ageing	186
Programmed and self-organized flow of information during morphogenesis	184
Human topoisomerases and their roles in genome stability and organization	183
Mechanics and functional consequences of nuclear deformations	181
A guide to membraneless organelles and their various roles in gene regulation	180
Phosphoinositides as membrane organizers	167
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	165
Nuclear compartmentalization as a mechanism of quantitative control of gene expression	164
The physiology of alternative splicing	161
Cell–extracellular matrix mechanotransduction in 3D	158
Regulation of microtubule dynamics, mechanics and function through the growing tip	157
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization	154
Causes and consequences of RNA polymerase II stalling during transcript elongation	151
The emerging mechanisms and functions of microautophagy	150
Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions	149
Signalling mechanisms and cellular functions of SUMO	145
Liver regeneration and inflammation: from fundamental science to clinical applications	145
An expanded lexicon for the ubiquitin code	142
Cellular functions of the protein kinase ATM and their relevance to human disease	136
Mechanisms controlling cellular and systemic iron homeostasis	136
Karyopherin-mediated nucleocytoplasmic transport	135
Pioneer factors as master regulators of the epigenome and cell fate	130
Context-specific regulation and function of mRNA alternative polyadenylation	128
The mechanisms of integral membrane protein biogenesis	128
Ageing and rejuvenation of tissue stem cells and their niches	128
Apical–basal polarity and the control of epithelial form and function	127
Biochemical and mechanical regulation of actin dynamics	127
Mechanisms of BCL-2 family proteins in mitochondrial apoptosis	124

Gene regulation in time and space during X-chromosome inactivation	117
The Mediator complex as a master regulator of transcription by RNA polymerase II	115
Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining	115
Roles of RNA silencing in viral and non-viral plant immunity and in the crosstalk between disease resistance systems	110
Metabolites as signalling molecules	106
Interplay between mechanics and signalling in regulating cell fate	99
Mechanisms of mitochondrial respiratory adaptation	98
The molecular basis for cellular function of intrinsically disordered protein regions	96
Emerging roles and functional mechanisms of PIWI-interacting RNAs	95
Understanding mechanisms of antioxidant action in health and disease	94
Plant and animal small RNA communications between cells and organisms	90
Regulation of axonal regeneration after mammalian spinal cord injury	86
Ubiquitin ligases: guardians of mammalian development	85
Principles and dynamics of spindle assembly checkpoint signalling	84
Selective motor activation in organelle transport along axons	83
Mechanisms of microtubule organization in differentiated animal cells	82
Regulation, functions and transmission of bivalent chromatin during mammalian development	81
Translational control of stem cell function	78
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	75
Biology and therapeutic targeting of vascular endothelial growth factor A	75
Mechanisms and roles of podosomes and invadopodia	73
Author Correction: Gene regulation by long non-coding RNAs and its biological functions	73
Regulation and functions of non-m6A mRNA modifications	71
Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins	69
Endocytosis in the context-dependent regulation of individual and collective cell properties	69
A guide to cell death pathways	67
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	67
Molecular and cellular basis of genetically inherited skeletal muscle disorders	65
Spindle positioning and its impact on vertebrate tissue architecture and cell fate	64
Aneuploidy in mammalian oocytes and the impact of maternal ageing	62
Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity	59
Mechanical regulation of early vertebrate embryogenesis	57
Exercise metabolism and adaptation in skeletal muscle	56
Transcriptional control of energy metabolism by nuclear receptors	56
Effects of aneuploidy on cell behaviour and function	56
The cell biology of ferroptosis	55
Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases	55
Cellular and molecular mechanisms of Hedgehog signalling	52
Deep learning shapes single-cell data analysis	51
Cellular and molecular mechanisms of skin wound healing	49
Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes	48
Cytoskeletal control of early mammalian development	46
Generation of nanoscopic membrane curvature for membrane trafficking	46
Cell competition in development, homeostasis and cancer	45
Mechanisms and pathology of protein misfolding and aggregation	45
Cellular functions of eukaryotic RNA helicases and their links to human diseases	44
Mechanisms of substrate processing during ER-associated protein degradation	44