Nature Reviews Molecular Cell Biology

(The TQCC of Nature Reviews Molecular Cell Biology is 44. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents1815
Gene regulation by long non-coding RNAs and its biological functions1741
Ferroptosis: mechanisms, biology and role in disease1405
mTOR at the nexus of nutrition, growth, ageing and disease1182
Reading, writing and erasing mRNA methylation1120
Mechanisms of SARS-CoV-2 entry into cells1059
Mitochondria as multifaceted regulators of cell death976
Guidelines and definitions for research on epithelial–mesenchymal transition914
Human organoids: model systems for human biology and medicine866
Mechanisms, regulation and functions of the unfolded protein response856
RNA delivery by extracellular vesicles in mammalian cells and its applications796
Mechanisms and regulation of cholesterol homeostasis713
The expanding regulatory mechanisms and cellular functions of circular RNAs660
Molecular mechanisms and cellular functions of cGAS–STING signalling637
Lysosomes as dynamic regulators of cell and organismal homeostasis597
Cellular senescence in ageing: from mechanisms to therapeutic opportunities583
The cell biology of mitochondrial membrane dynamics573
The regulation and functions of DNA and RNA G-quadruplexes567
Molecular mechanisms and physiological importance of circadian rhythms513
The many functions of ESCRTs472
Cellular adaptation to hypoxia through hypoxia inducible factors and beyond467
Mechanisms of 3D cell migration458
NAD+ metabolism and its roles in cellular processes during ageing436
Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing410
Global view of human protein glycosylation pathways and functions404
Mechanisms governing autophagosome biogenesis396
ERK signalling: a master regulator of cell behaviour, life and fate391
A guide to machine learning for biologists382
The tubulin code and its role in controlling microtubule properties and functions379
The nucleolus as a multiphase liquid condensate357
A framework for understanding the functions of biomolecular condensates across scales345
Applications of CRISPR–Cas in agriculture and plant biotechnology338
Emerging connectivity of programmed cell death pathways and its physiological implications335
The functional universe of membrane contact sites323
Cell cycle control in cancer323
Mechanisms of bone development and repair308
The clearance of dead cells by efferocytosis304
Reactive oxygen species signalling in plant stress responses294
RNA contributions to the form and function of biomolecular condensates272
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology268
Regulatory R-loops as facilitators of gene expression and genome stability236
Cell fate specification and differentiation in the adult mammalian intestine223
The ageing epigenome and its rejuvenation222
Challenges and directions in studying cell–cell communication by extracellular vesicles218
Mechanisms controlling pancreatic islet cell function in insulin secretion210
Genome folding through loop extrusion by SMC complexes198
Diversity and versatility of p38 kinase signalling in health and disease193
Molecular mechanisms of dietary restriction promoting health and longevity193
The roles of histone variants in fine-tuning chromatin organization and function183
Quality control of the mitochondrial proteome182
The expanding world of tRNA modifications and their disease relevance177
The molecular basis and disease relevance of non-homologous DNA end joining172
Control of DNA replication timing in the 3D genome170
Machinery, regulation and pathophysiological implications of autophagosome maturation168
The principles of directed cell migration167
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication166
The DNA damage response to transcription stress160
The roles of Polycomb repressive complexes in mammalian development and cancer157
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design156
Regulation of human telomerase in homeostasis and disease156
The plasticity of DNA replication forks in response to clinically relevant genotoxic stress156
The aetiology and molecular landscape of insulin resistance151
The cellular and functional complexity of thermogenic fat149
Target gene-independent functions of MYC oncoproteins148
The assembly, regulation and function of the mitochondrial respiratory chain145
Crosstalk between mechanotransduction and metabolism145
The molecular principles governing the activity and functional diversity of AAA+ proteins144
Understanding 3D genome organization by multidisciplinary methods143
Modulation of cellular processes by histone and non-histone protein acetylation142
The molecular principles of gene regulation by Polycomb repressive complexes137
Plant hormone regulation of abiotic stress responses131
Proteomic and interactomic insights into the molecular basis of cell functional diversity129
Direct cell reprogramming: approaches, mechanisms and progress127
Mechanisms and regulation of protein synthesis in mitochondria125
Intracellular mRNA transport and localized translation122
Programmed and self-organized flow of information during morphogenesis118
Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery114
Molecular mechanisms and consequences of mitochondrial permeability transition111
Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression110
Unravelling cellular relationships during development and regeneration using genetic lineage tracing107
Molecular mechanisms underlying nucleotide repeat expansion disorders105
Membrane and organelle dynamics during cell division104
Long non-coding RNAs: definitions, functions, challenges and recommendations103
MicroRNA-mediated regulation of glucose and lipid metabolism102
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization100
Nuclear compartmentalization as a mechanism of quantitative control of gene expression98
Causes and consequences of RNA polymerase II stalling during transcript elongation94
Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics90
Control of satellite cell function in muscle regeneration and its disruption in ageing86
Liver regeneration and inflammation: from fundamental science to clinical applications85
Regulation of microtubule dynamics, mechanics and function through the growing tip80
Cellular functions of the protein kinase ATM and their relevance to human disease75
Roles of transposable elements in the regulation of mammalian transcription75
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance75
Setting the standards for machine learning in biology73
The mechanisms of integral membrane protein biogenesis70
Human topoisomerases and their roles in genome stability and organization69
A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing68
Karyopherin-mediated nucleocytoplasmic transport65
Mechanics and functional consequences of nuclear deformations62
Cellular origins of dsRNA, their recognition and consequences62
Phosphoinositides as membrane organizers58
Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining57
Pioneer factors as master regulators of the epigenome and cell fate56
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids54
Translational control of stem cell function52
Apical–basal polarity and the control of epithelial form and function51
Regulation of membrane protein structure and function by their lipid nano-environment51
Plant and animal small RNA communications between cells and organisms51
COVID-19 management in light of the circadian clock50
The mechanisms and roles of selective autophagy in mammals49
Signalling mechanisms and cellular functions of SUMO48
Roles of RNA silencing in viral and non-viral plant immunity and in the crosstalk between disease resistance systems46
Cell–cell interfaces as specialized compartments directing cell function46
Endocytosis in the context-dependent regulation of individual and collective cell properties46
Gene regulation in time and space during X-chromosome inactivation45
Ageing and rejuvenation of tissue stem cells and their niches45
The Mediator complex as a master regulator of transcription by RNA polymerase II44
Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions44
COVID-19: organoids go viral44
New insights into activation and function of the AMPK44