Nature Reviews Molecular Cell Biology

(The TQCC of Nature Reviews Molecular Cell Biology is 43. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-06-01 to 2024-06-01.)
Ferroptosis: mechanisms, biology and role in disease2480
Gene regulation by long non-coding RNAs and its biological functions2437
Mechanisms of SARS-CoV-2 entry into cells1622
Human organoids: model systems for human biology and medicine1123
Cellular senescence in ageing: from mechanisms to therapeutic opportunities886
A guide to machine learning for biologists691
NAD+ metabolism and its roles in cellular processes during ageing632
Reactive oxygen species signalling in plant stress responses622
Global view of human protein glycosylation pathways and functions601
Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing585
ERK signalling: a master regulator of cell behaviour, life and fate575
Cell cycle control in cancer559
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology551
The nucleolus as a multiphase liquid condensate505
Emerging connectivity of programmed cell death pathways and its physiological implications491
Mechanisms of bone development and repair485
A framework for understanding the functions of biomolecular condensates across scales478
Applications of CRISPR–Cas in agriculture and plant biotechnology441
Long non-coding RNAs: definitions, functions, challenges and recommendations430
Challenges and directions in studying cell–cell communication by extracellular vesicles427
RNA contributions to the form and function of biomolecular condensates362
Plant hormone regulation of abiotic stress responses348
Cell fate specification and differentiation in the adult mammalian intestine318
The assembly, regulation and function of the mitochondrial respiratory chain309
The expanding world of tRNA modifications and their disease relevance309
Molecular mechanisms of dietary restriction promoting health and longevity302
Mechanisms controlling pancreatic islet cell function in insulin secretion293
Genome folding through loop extrusion by SMC complexes287
The principles of directed cell migration287
Modulation of cellular processes by histone and non-histone protein acetylation272
Diversity and versatility of p38 kinase signalling in health and disease272
The aetiology and molecular landscape of insulin resistance250
Quality control of the mitochondrial proteome248
Machinery, regulation and pathophysiological implications of autophagosome maturation247
The mechanisms and roles of selective autophagy in mammals241
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design233
The roles of histone variants in fine-tuning chromatin organization and function230
The molecular basis and disease relevance of non-homologous DNA end joining228
The molecular principles of gene regulation by Polycomb repressive complexes227
The roles of Polycomb repressive complexes in mammalian development and cancer222
The cellular and functional complexity of thermogenic fat220
Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression210
The plasticity of DNA replication forks in response to clinically relevant genotoxic stress209
Crosstalk between mechanotransduction and metabolism204
Understanding 3D genome organization by multidisciplinary methods203
Molecular mechanisms and consequences of mitochondrial permeability transition195
Direct cell reprogramming: approaches, mechanisms and progress191
New insights into activation and function of the AMPK191
Mechanisms and regulation of protein synthesis in mitochondria185
Intracellular mRNA transport and localized translation177
Autophagy and autophagy-related pathways in cancer171
MicroRNA-mediated regulation of glucose and lipid metabolism170
Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics170
Programmed and self-organized flow of information during morphogenesis166
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance166
Molecular mechanisms underlying nucleotide repeat expansion disorders164
Regulation of membrane protein structure and function by their lipid nano-environment162
Roles of transposable elements in the regulation of mammalian transcription156
Control of satellite cell function in muscle regeneration and its disruption in ageing156
Mechanics and functional consequences of nuclear deformations150
Nuclear compartmentalization as a mechanism of quantitative control of gene expression147
Human topoisomerases and their roles in genome stability and organization145
Context-specific regulation of extracellular vesicle biogenesis and cargo selection144
Cellular origins of dsRNA, their recognition and consequences141
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization141
Causes and consequences of RNA polymerase II stalling during transcript elongation135
Regulation of microtubule dynamics, mechanics and function through the growing tip134
Phosphoinositides as membrane organizers134
Liver regeneration and inflammation: from fundamental science to clinical applications129
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids129
A guide to membraneless organelles and their various roles in gene regulation128
The emerging mechanisms and functions of microautophagy126
The technological landscape and applications of single-cell multi-omics123
Karyopherin-mediated nucleocytoplasmic transport120
Signalling mechanisms and cellular functions of SUMO117
The physiology of alternative splicing115
Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions115
The mechanisms of integral membrane protein biogenesis115
Cellular functions of the protein kinase ATM and their relevance to human disease113
Pioneer factors as master regulators of the epigenome and cell fate108
An expanded lexicon for the ubiquitin code108
Apical–basal polarity and the control of epithelial form and function108
Context-specific regulation and function of mRNA alternative polyadenylation106
Cell–extracellular matrix mechanotransduction in 3D105
Ageing and rejuvenation of tissue stem cells and their niches103
Gene regulation in time and space during X-chromosome inactivation98
Biochemical and mechanical regulation of actin dynamics98
Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining97
Roles of RNA silencing in viral and non-viral plant immunity and in the crosstalk between disease resistance systems93
Interplay between mechanics and signalling in regulating cell fate86
The Mediator complex as a master regulator of transcription by RNA polymerase II86
A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing85
Plant and animal small RNA communications between cells and organisms81
Emerging roles and functional mechanisms of PIWI-interacting RNAs76
Mechanisms of mitochondrial respiratory adaptation75
Metabolites as signalling molecules74
Mechanisms of BCL-2 family proteins in mitochondrial apoptosis74
Translational control of stem cell function71
Selective motor activation in organelle transport along axons70
Mechanisms of microtubule organization in differentiated animal cells68
Principles and dynamics of spindle assembly checkpoint signalling67
Regulation, functions and transmission of bivalent chromatin during mammalian development65
Cell–cell interfaces as specialized compartments directing cell function64
Endocytosis in the context-dependent regulation of individual and collective cell properties64
Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins63
Ubiquitin ligases: guardians of mammalian development63
Author Correction: Gene regulation by long non-coding RNAs and its biological functions62
Spindle positioning and its impact on vertebrate tissue architecture and cell fate61
Molecular and cellular basis of genetically inherited skeletal muscle disorders61
Mechanisms controlling cellular and systemic iron homeostasis58
Regulation of axonal regeneration after mammalian spinal cord injury58
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways58
Acquired genetic changes in human pluripotent stem cells: origins and consequences58
COVID-19 management in light of the circadian clock53
Mechanisms and roles of podosomes and invadopodia51
Transcriptional control of energy metabolism by nuclear receptors50
Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases49
COVID-19: organoids go viral49
Mechanical regulation of early vertebrate embryogenesis47
The molecular basis for cellular function of intrinsically disordered protein regions46
Biology and therapeutic targeting of vascular endothelial growth factor A43
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases43
Effects of aneuploidy on cell behaviour and function43