OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Molecular Cell Biology is 47. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
When senescence generates pluripotent stem cells	2227
Tightening the epithelium to control signalling	1431
Histone H1 deamidation regulates DNA double-strand break repair	1323
The secretory pathway gets a molecular framework	1311
A dynamic culture system that models the intricacy of the mammary gland	970
Transfection reflections: fit-for-purpose delivery of nucleic acids	959
DNA-repair-driven cell death compels us to rethink cancer therapies	929
Advancing single-cell omics and cell-based therapeutics with quantum computing	844
The translation m(o)TOR that propels regeneration	778
Plucking cellular ribosomes with Ribo-Tweezer	740
Single-cell evidence for PANoptosome complexes	733
Mechanisms of substrate processing during ER-associated protein degradation	713
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	704
Understanding mechanisms of antioxidant action in health and disease	632
Regulation of RNA transcript elongation in metazoans and its relevance to disease	597
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	567
Decoding the Ca2+ signal for salt tolerance	557
The double life of a transcription factor in the cytoplasm	548
Chemical reprogramming of human blood cells	511
Resilience through selective translation	480
Programmed ‘DNA splicing’ removes transposons from genes	442
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	432
How proteins sense their cellular environment	422
PIONEARing how DNA sequence composition tunes TF–nucleosome interactions	402
Engineered nanobodies facilitate cryo-EM studies of small proteins	384

Progress in stem cell-based embryo models and their applications in developmental biology and biomedicine	383
The advent of confocal laser scanning microscopy in biological research	354
Mechanism and regulation of kinesin motors	347
The emerging mechanisms and functions of microautophagy	345
N-glycan-dependent protein maturation and quality control in the ER	340
New insights into activation and function of the AMPK	318
C-degron mimicry confers E3 ligase selectivity	312
The discovery of oncogene-induced senescence	307
Nucleosomes as blueprints of genome architecture	294
Silencing centromeres with age	287
Bookmarking pluripotency genes	271
Studying lysosomal function and dysfunction using LysoIP	269
DNA looping regulates transcription	269
Coordination of cardiogenesis in vivo and in vitro	266
Biology and therapeutic potential of extracellular vesicle targeting and uptake	264
Mechanisms and roles of podosomes and invadopodia	253
Regulation, functions and transmission of bivalent chromatin during mammalian development	249
Biology and therapeutic targeting of vascular endothelial growth factor A	242
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	240
ESCRT-III function in membrane fission and repair	236
Regulation of membrane protein structure and function by their lipid nano-environment	233
Telomere function and regulation from mouse models to human ageing and disease	229
CRISPR–Cas applications in agriculture and plant research	219
A quick guide to (transmembrane) planar cell polarity mouse strains	218
Snoozing APC/C for a sweet cell cycle entry	210
A histone variant that manages abiotic stress in plants	199
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	197
Improving chemical reprogramming strategies	196
Migrasomes promote angiogenesis	196
Circadian clock communication during homeostasis and ageing	184
Molecular tools for analysing in vivo senescence	184
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	184
Programmable delivery of mitochondria to specific cell types	183
Context-dependent TGFβ family signalling in cell fate regulation	178
Splicing regulation through biomolecular condensates and membraneless organelles	177
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	173
Science Twitter — navigating change in science communication	165
FOXO transcription factors as mediators of stress adaptation	162
RNA binding — a useful third wheel in transcription	155
Like water on rock, the microenvironment bends stem cell fate	154
Activation of human endogenous retroviruses and its physiological consequences	148
Mechanisms and regulation of the Hsp70 chaperone network	146
Subcellular localization as a driver of protein function	146
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	145
Energy-driven genome regulation by ATP-dependent chromatin remodellers	145
Organelles stick together through PDZD8-mediated condensate formation	144
How ancient RNA survives and what we can learn from it	139
Does species-specific alternative splicing make us human?	135
Regulation and function of insulin and insulin-like growth factor receptor signalling	134
Molecular machineries and pathways of mitochondrial protein transport	130

Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	129
Targeted protein degradation: from mechanisms to clinic	121
A guide to cell death pathways	118
Myosin VI assists in fork protection	114
Decoding ubiquitin signals inside cells	111
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	111
The centromere as a tag of self-DNA	111
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	109
Cold-induced longevity through proteasome boosting	109
Redox-driven cell death by disulfidptosis and its therapeutic potential	108
A demonstration that multivalent interactions drive condensate formation	108
New frontiers in quality control: the case of GPI-anchored proteins	108
Effortless immortalization of primary mouse fibroblasts	103
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	100
COPII meets autophagy at the ER membrane	100
The molecular basis for cellular function of intrinsically disordered protein regions	99
The technological landscape and applications of single-cell multi-omics	97
DEI conversations: more than a box-ticking exercise	95
Genome characteristics at the borders	95
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	93
Fat cells have long-lasting (epigenetic) memory	89
Anticancer effects of zotatifin are mediated by RNA structure remodelling	87
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	87
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	86
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	85
Microenvironmental determinants of endothelial cell heterogeneity	84
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	84
New developments and applications of human organoids	83
Caveolae mechanics in cellular functions and disease	79
The role and regulation of integrins in cell migration and invasion	76
Exchange dynamics and kinetic control of gene regulation complexes	75
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	74
Profiling the disordered proteome in cells using a chemical tag	73
The contribution of databases towards understanding the universe of long non-coding RNAs	62
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	58
The hunter becomes the hunted in target-directed microRNA degradation	56
Transcription factors crossing the cell membrane	55
From shortening telomeres to replicative crisis	54
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	54
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	53
Mechanisms and regulation of substrate degradation by the 26S proteasome	51
Reply to ‘Single-cell evidence for PANoptosome complexes’	50
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	49
Exercise metabolism and adaptation in skeletal muscle	49
Neural crest gene regulatory networks as drivers of development, diversification and disease	48
Translation feedback control in the brain	47
Cellular role of TETs in early embryos	47