OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Molecular Cell Biology is 44. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)

Article	Citations
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents	1815
Gene regulation by long non-coding RNAs and its biological functions	1741
Ferroptosis: mechanisms, biology and role in disease	1405
mTOR at the nexus of nutrition, growth, ageing and disease	1182
Reading, writing and erasing mRNA methylation	1120
Mechanisms of SARS-CoV-2 entry into cells	1059
Mitochondria as multifaceted regulators of cell death	976
Guidelines and definitions for research on epithelial–mesenchymal transition	914
Human organoids: model systems for human biology and medicine	866
Mechanisms, regulation and functions of the unfolded protein response	856
RNA delivery by extracellular vesicles in mammalian cells and its applications	796
Mechanisms and regulation of cholesterol homeostasis	713
The expanding regulatory mechanisms and cellular functions of circular RNAs	660
Molecular mechanisms and cellular functions of cGAS–STING signalling	637
Lysosomes as dynamic regulators of cell and organismal homeostasis	597
Cellular senescence in ageing: from mechanisms to therapeutic opportunities	583
The cell biology of mitochondrial membrane dynamics	573
The regulation and functions of DNA and RNA G-quadruplexes	567
Molecular mechanisms and physiological importance of circadian rhythms	513
The many functions of ESCRTs	472
Cellular adaptation to hypoxia through hypoxia inducible factors and beyond	467
Mechanisms of 3D cell migration	458
NAD+ metabolism and its roles in cellular processes during ageing	436
Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing	410
Global view of human protein glycosylation pathways and functions	404

Mechanisms governing autophagosome biogenesis	396
ERK signalling: a master regulator of cell behaviour, life and fate	391
A guide to machine learning for biologists	382
The tubulin code and its role in controlling microtubule properties and functions	379
The nucleolus as a multiphase liquid condensate	357
A framework for understanding the functions of biomolecular condensates across scales	345
Applications of CRISPR–Cas in agriculture and plant biotechnology	338
Emerging connectivity of programmed cell death pathways and its physiological implications	335
The functional universe of membrane contact sites	323
Cell cycle control in cancer	323
Mechanisms of bone development and repair	308
The clearance of dead cells by efferocytosis	304
Reactive oxygen species signalling in plant stress responses	294
RNA contributions to the form and function of biomolecular condensates	272
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology	268
Regulatory R-loops as facilitators of gene expression and genome stability	236
Cell fate specification and differentiation in the adult mammalian intestine	223
The ageing epigenome and its rejuvenation	222
Challenges and directions in studying cell–cell communication by extracellular vesicles	218
Mechanisms controlling pancreatic islet cell function in insulin secretion	210
Genome folding through loop extrusion by SMC complexes	198
Diversity and versatility of p38 kinase signalling in health and disease	193
Molecular mechanisms of dietary restriction promoting health and longevity	193
The roles of histone variants in fine-tuning chromatin organization and function	183
Quality control of the mitochondrial proteome	182
The expanding world of tRNA modifications and their disease relevance	177
The molecular basis and disease relevance of non-homologous DNA end joining	172
Control of DNA replication timing in the 3D genome	170
Machinery, regulation and pathophysiological implications of autophagosome maturation	168
The principles of directed cell migration	167
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication	166
The DNA damage response to transcription stress	160
The roles of Polycomb repressive complexes in mammalian development and cancer	157
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design	156
Regulation of human telomerase in homeostasis and disease	156
The plasticity of DNA replication forks in response to clinically relevant genotoxic stress	156
The aetiology and molecular landscape of insulin resistance	151
The cellular and functional complexity of thermogenic fat	149
Target gene-independent functions of MYC oncoproteins	148
The assembly, regulation and function of the mitochondrial respiratory chain	145
Crosstalk between mechanotransduction and metabolism	145
The molecular principles governing the activity and functional diversity of AAA+ proteins	144
Understanding 3D genome organization by multidisciplinary methods	143
Modulation of cellular processes by histone and non-histone protein acetylation	142
The molecular principles of gene regulation by Polycomb repressive complexes	137
Plant hormone regulation of abiotic stress responses	131
Proteomic and interactomic insights into the molecular basis of cell functional diversity	129
Direct cell reprogramming: approaches, mechanisms and progress	127
Mechanisms and regulation of protein synthesis in mitochondria	125
Intracellular mRNA transport and localized translation	122

Programmed and self-organized flow of information during morphogenesis	118
Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery	114
Molecular mechanisms and consequences of mitochondrial permeability transition	111
Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression	110
Unravelling cellular relationships during development and regeneration using genetic lineage tracing	107
Molecular mechanisms underlying nucleotide repeat expansion disorders	105
Membrane and organelle dynamics during cell division	104
Long non-coding RNAs: definitions, functions, challenges and recommendations	103
MicroRNA-mediated regulation of glucose and lipid metabolism	102
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization	100
Nuclear compartmentalization as a mechanism of quantitative control of gene expression	98
Causes and consequences of RNA polymerase II stalling during transcript elongation	94
Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	90
Control of satellite cell function in muscle regeneration and its disruption in ageing	86
Liver regeneration and inflammation: from fundamental science to clinical applications	85
Regulation of microtubule dynamics, mechanics and function through the growing tip	80
Cellular functions of the protein kinase ATM and their relevance to human disease	75
Roles of transposable elements in the regulation of mammalian transcription	75
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	75
Setting the standards for machine learning in biology	73
The mechanisms of integral membrane protein biogenesis	70
Human topoisomerases and their roles in genome stability and organization	69
A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing	68
Karyopherin-mediated nucleocytoplasmic transport	65
Mechanics and functional consequences of nuclear deformations	62
Cellular origins of dsRNA, their recognition and consequences	62
Phosphoinositides as membrane organizers	58
Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining	57
Pioneer factors as master regulators of the epigenome and cell fate	56
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	54
Translational control of stem cell function	52
Apical–basal polarity and the control of epithelial form and function	51
Regulation of membrane protein structure and function by their lipid nano-environment	51
Plant and animal small RNA communications between cells and organisms	51
COVID-19 management in light of the circadian clock	50
The mechanisms and roles of selective autophagy in mammals	49
Signalling mechanisms and cellular functions of SUMO	48
Roles of RNA silencing in viral and non-viral plant immunity and in the crosstalk between disease resistance systems	46
Cell–cell interfaces as specialized compartments directing cell function	46
Endocytosis in the context-dependent regulation of individual and collective cell properties	46
Gene regulation in time and space during X-chromosome inactivation	45
Ageing and rejuvenation of tissue stem cells and their niches	45
The Mediator complex as a master regulator of transcription by RNA polymerase II	44
Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions	44
COVID-19: organoids go viral	44
New insights into activation and function of the AMPK	44