Nature Reviews Molecular Cell Biology

Article	Citations
The translation m(o)TOR that propels regeneration	2240
When senescence generates pluripotent stem cells	1163
Tightening the epithelium to control signalling	1130
Transfection reflections: fit-for-purpose delivery of nucleic acids	1127
A dynamic culture system that models the intricacy of the mammary gland	976
From trans-splicing discovery and onwards, trypanosomes lead the way	913
Re-sizing of nuclear pores	721
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	703
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	655
Mechanisms of substrate processing during ER-associated protein degradation	553
The aetiology and molecular landscape of insulin resistance	545
Modulation of cellular processes by histone and non-histone protein acetylation	498
Understanding mechanisms of antioxidant action in health and disease	473
How proteins sense their cellular environment	459
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	450
Decoding the Ca2+ signal for salt tolerance	431
Resilience through selective translation	391
Damaged mitochondria are discarded via migrasomes	363
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	355
Endocytosis in the context-dependent regulation of individual and collective cell properties	350
Mechanism and regulation of kinesin motors	330
The emerging mechanisms and functions of microautophagy	329
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	324
Publisher Correction: Plant hormone regulation of abiotic stress responses	317
New insights into activation and function of the AMPK	312

Spindle positioning and its impact on vertebrate tissue architecture and cell fate	311
The healing role of gasdermin B in IBD	287
CRISPR–Cas applications in agriculture and plant research	286
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	283
Telomere function and regulation from mouse models to human ageing and disease	282
C-degron mimicry confers E3 ligase selectivity	279
Bookmarking pluripotency genes	278
Silencing centromeres with age	277
Voices of the new generation: open science is good for science (and for you)	273
The discovery of oncogene-induced senescence	272
Studying lysosomal function and dysfunction using LysoIP	272
Regulation, functions and transmission of bivalent chromatin during mammalian development	269
Regulation of membrane protein structure and function by their lipid nano-environment	259
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design	254
Biology and therapeutic targeting of vascular endothelial growth factor A	254
Curvature-mediated endocytosis	248
Mechanisms and roles of podosomes and invadopodia	248
The RNA world ‘hypothesis’	247
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	244
Big cells, small potential	244
Molecular tools for analysing in vivo senescence	227
A quick guide to (transmembrane) planar cell polarity mouse strains	226
Science Twitter — navigating change in science communication	222
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	217
Context-dependent TGFβ family signalling in cell fate regulation	206
Splicing regulation through biomolecular condensates and membraneless organelles	198
Migrasomes promote angiogenesis	198
The prospects and opportunities of protein structure prediction with AI	196
Improving chemical reprogramming strategies	189
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	187
Why novel mRNA modifications are so challenging and what we can do about it	186
FOXO transcription factors as mediators of stress adaptation	183
Circadian clock communication during homeostasis and ageing	183
Machinery, regulation and pathophysiological implications of autophagosome maturation	182
Molecular mechanisms and consequences of mitochondrial permeability transition	178
Transposons: catch them if you can	172
New tool for MAPping microtubule dynamics	168
RNA binding — a useful third wheel in transcription	168
Activation of human endogenous retroviruses and its physiological consequences	161
Context-specific regulation and function of mRNA alternative polyadenylation	148
Replication stress as a trigger for cell extrusion	148
Energy-driven genome regulation by ATP-dependent chromatin remodellers	148
Mechanisms of mitochondrial respiratory adaptation	148
Does species-specific alternative splicing make us human?	146
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	143
Revisiting small RNA movement in plants	142
Regulation and function of insulin and insulin-like growth factor receptor signalling	140
Apical–basal polarity and the control of epithelial form and function	135
Transcriptional control of energy metabolism by nuclear receptors	132
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	127

A guide to cell death pathways	118
Targeted protein degradation: from mechanisms to clinic	117
Myosin VI assists in fork protection	116
How ancient RNA survives and what we can learn from it	116
Cold-induced longevity through proteasome boosting	115
A Tour de force of primary cilium biogenesis	115
New frontiers in quality control: the case of GPI-anchored proteins	114
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	111
The centromere as a tag of self-DNA	110
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	109
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	108
The molecular basis for cellular function of intrinsically disordered protein regions	107
Molecular mechanisms underlying nucleotide repeat expansion disorders	105
The technological landscape and applications of single-cell multi-omics	104
DEI conversations: more than a box-ticking exercise	103
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	95
Microenvironmental determinants of endothelial cell heterogeneity	94
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	91
Fat cells have long-lasting (epigenetic) memory	87
Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition	86
Genome characteristics at the borders	86
ATP and ROS signal cell extrusion	84
Deep learning shapes single-cell data analysis	83
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	83
Anticancer effects of zotatifin are mediated by RNA structure remodelling	81
Nuclear compartmentalization as a mechanism of quantitative control of gene expression	78
Interplay between mechanics and signalling in regulating cell fate	78
The role and regulation of integrins in cell migration and invasion	78
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	77
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	76
Sleep tight thanks to Parp1	76
Mechanisms of microtubule organization in differentiated animal cells	76
RAG-ulating mTORC1 with amino acids	74
Ethylene — the lifeguard hormone	71
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	71
Unravelling oocyte ultrastructure	70
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	68
From shortening telomeres to replicative crisis	67
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	65
The contribution of databases towards understanding the universe of long non-coding RNAs	65
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	62
Transcription factors crossing the cell membrane	59
How green is your science? The race to make laboratories sustainable	57
The molecular principles of gene regulation by Polycomb repressive complexes	56
Profiling the disordered proteome in cells using a chemical tag	56
Karyopherin-mediated nucleocytoplasmic transport	55
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	54
Mechanisms of SARS-CoV-2 entry into cells	53
Mechanisms and regulation of substrate degradation by the 26S proteasome	51
Exercise metabolism and adaptation in skeletal muscle	51
The many regulators of epithelial−mesenchymal transition	50
EV signalling in the haematopoietic niche	50
Cellular role of TETs in early embryos	49
Cellular and molecular control of vertebrate somitogenesis	48
Translation feedback control in the brain	47
Author Correction: The role of the haematopoietic stem cell niche in development and ageing	46
Following the electric current	45
The senescence-associated secretory phenotype and its physiological and pathological implications	45
The birth of evo-devo	40
SWI/SNF chromatin remodellers persist through mitosis	36
Deciphering ADP-ribosylation signalling	36
Calcium connects lysosomal damage to stress granule formation	35
Mechanisms and regulation of DNA end resection in the maintenance of genome stability	34
The bioethics of synthetic cells	34
The bystander effect of pyroptosis	33
The principles of directed cell migration	29
Keeping oocytes young	28
Mediat(or)ing adult stem cells by XIST	27
Harnessing fluorescent probes to unveil dynamic membrane mechanics	26
Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking	26
Voices of the new generation: my unconventional way to stay in academia	26
ERMES — from myths to molecules	26
Spatiotemporal control over cell–matrix interactions using dynamic micropatterns	26
ncRNA regulation of mitochondrial transcription	24
Proteins that assemble co-translationally lean on their partner for stability	24
Signalling mechanisms and cellular functions of SUMO	23
Local and systemic mechanisms that control the hair follicle stem cell niche	23
Mechanical state transitions in the regulation of tissue form and function	23
Present and future of synthetic cell development	23
Internal-m7G-modified mRNAs quake under stress	22

Author Correction: Molecular mechanisms underlying nucleotide repeat expansion disorders	21
Let’s talk about (biological) sex	20
Sorting membrane proteins by size in the Golgi	20
Lasker Award for AlphaFold	20
Smelling your way to longevity	20
Epigenetic discovery by enzyme activity profiling	20
Blebbisomes are one bleb away from a functional cell	19
A nuclear morphology-based machine learning algorithm for senescence detection	19
The nuance in DNA and transcription factor interactions	19
Early insights into co-translational assembly of protein complexes	17
Cracking genetic codes of longevity	17
Size matters	16
Translating the midbody for cytokinesis	15
The birth of stable introns	15
Translational control of stem cell function	14
Cellular functions of the protein kinase ATM and their relevance to human disease	14
Mitochondrial ROS drive cell cycle progression	13
Cellular functions of eukaryotic RNA helicases and their links to human diseases	12
m6A nuclear condensates support AML	12
Control of satellite cell function in muscle regeneration and its disruption in ageing	12
New imprinting control-like regions	11
The discovery of cyclin-dependent kinases	11
5mC: what goes on must come off	10
BCL-2 proteins in senescence: beyond a simple target for senolysis?	10
Mapping organelle supply chains	10
Pioneer factors as master regulators of the epigenome and cell fate	10
Mechanisms and regulation of human mitochondrial transcription	10
Author Correction: Fundamentals of redox regulation in biology	9
Single-cell lipidomics reveals the organizing principle of cell fate decision	9
Genome control by SMC complexes	9
Viruses show the way	9
Mechanistic insights into gasdermin-mediated pyroptosis	9
Paleoproteomics sheds light on million-year-old fossils	8
Monitoring subcellular protein localization at scale in live cells	8
The role of ordered cooperative assembly in biomolecular condensates	7
Effects of aneuploidy on cell behaviour and function	7
Gene regulation in time and space during X-chromosome inactivation	7
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing	7
Exploring the uncharted landscape of truncated mRNAs	7
Shaping epithelial tissues by stem cell mechanics in development and cancer	7
Cell–extracellular matrix mechanotransduction in 3D	7
Modes of Notch signalling in development and disease	6
The lipotype hypothesis	6
Returning to the lab after a career break	6
A novel photosystem assembly line worker	6
The double-edged sword of bivalency	6
oskar stands on solid ground for translation	6
The role of the haematopoietic stem cell niche in development and ageing	5
Protrusion-derived vesicles: new subtype of EVs?	5
Modelling human brain development and disease with organoids	5
Principles and dynamics of spindle assembly checkpoint signalling	5
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation	5
Mechanics and functional consequences of nuclear deformations	5
A catalytic function for mammalian Argonautes	4
Probing cytoskeletal remodelling by cutting and marking filaments	4
How embryos sort themselves out	4
BERing transcriptional noise for cell plasticity	4
Condensates trail the nucleus	4
A histone code controls positional identity in limb regeneration	4
Compression as a driver of hair loss	4
DNA modifications walk a fine line between epigenetics and mutagenesis	4
The prompt to discover senolytics	4
The memory of viscosity	3
A guide to machine learning for biologists	3
Regulation and functions of non-m6A mRNA modifications	3
Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer	3
Challenges and opportunities in macromolecular structure determination	3
Regulation of microtubule dynamics, mechanics and function through the growing tip	3
Senescent cells support limb regeneration	3
Regulation of and challenges in targeting NAD+ metabolism	3
Mechanisms of mechanotransduction and physiological roles of PIEZO channels	3
Base editing of organellar DNA with programmable deaminases	3
The neuronal epigenome is special	3
RNF26 and vimentin orchestrate ER stress recovery	3
Genome doubling — twice the same is not the same	2
MYC in TOP shape	2
Biochemical and mechanical regulation of actin dynamics	2
oskar switches motors halfway through its journey	2
Control of stem cell renewal and fate by YAP and TAZ	2
First demonstration of miRNA-dependent mRNA decay	2
Cell cycle control in cancer	2
Cell quiescence sends argonaute-2 to transposons	2
The cell biology of ferroptosis	2
The multiple links between actin and mitochondria	2
Slow cell death helps tissue repair	2
Neurons whisper, tissues respond: neurons as orchestrators of stress responses	2
A code within the genetic code	2
RNA polymerase II transcription compartments: from multivalent chromatin binding to liquid droplet formation?	2
The discovery of simple repeats that cause complex disorders	2
Modelling tauopathies	2
Dicing viral RNA in stem cells	2
Cytosol-to-nucleus journey of a novel histone PTM	2
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics	2
A guide to membraneless organelles and their various roles in gene regulation	2
A SOX9 switch from regeneration to fibrosis	2