Nature Reviews Molecular Cell Biology

Article	Citations
When senescence generates pluripotent stem cells	2019
The translation m(o)TOR that propels regeneration	1941
Tightening the epithelium to control signalling	1207
Histone H1 deamidation regulates DNA double-strand break repair	1193
The secretory pathway gets a molecular framework	1147
A dynamic culture system that models the intricacy of the mammary gland	1063
Transfection reflections: fit-for-purpose delivery of nucleic acids	878
DNA-repair-driven cell death compels us to rethink cancer therapies	863
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	838
Understanding mechanisms of antioxidant action in health and disease	722
Advancing single-cell omics and cell-based therapeutics with quantum computing	644
Mechanisms of substrate processing during ER-associated protein degradation	643
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	625
Decoding the Ca2+ signal for salt tolerance	617
The double life of a transcription factor in the cytoplasm	612
Chemical reprogramming of human blood cells	554
Resilience through selective translation	503
Mechanism and regulation of kinesin motors	491
Engineered nanobodies facilitate cryo-EM studies of small proteins	487
The advent of confocal laser scanning microscopy in biological research	487
Progress in stem cell-based embryo models and their applications in developmental biology and biomedicine	486
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	466
How proteins sense their cellular environment	435
PIONEARing how DNA sequence composition tunes TF–nucleosome interactions	435
Programmed ‘DNA splicing’ removes transposons from genes	414

N-glycan-dependent protein maturation and quality control in the ER	396
The emerging mechanisms and functions of microautophagy	390
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	369
Publisher Correction: Plant hormone regulation of abiotic stress responses	365
New insights into activation and function of the AMPK	331
C-degron mimicry confers E3 ligase selectivity	329
Nucleosomes as blueprints of genome architecture	318
Silencing centromeres with age	315
Bookmarking pluripotency genes	303
Coordination of cardiogenesis in vivo and in vitro	293
DNA looping regulates transcription	288
Studying lysosomal function and dysfunction using LysoIP	283
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	282
ESCRT-III function in membrane fission and repair	281
Telomere function and regulation from mouse models to human ageing and disease	275
The discovery of oncogene-induced senescence	267
CRISPR–Cas applications in agriculture and plant research	256
Biology and therapeutic potential of extracellular vesicle targeting and uptake	256
Regulation of membrane protein structure and function by their lipid nano-environment	253
Biology and therapeutic targeting of vascular endothelial growth factor A	250
Mechanisms and roles of podosomes and invadopodia	246
Regulation, functions and transmission of bivalent chromatin during mammalian development	241
Curvature-mediated endocytosis	230
Molecular tools for analysing in vivo senescence	225
A quick guide to (transmembrane) planar cell polarity mouse strains	219
Snoozing APC/C for a sweet cell cycle entry	213
A histone variant that manages abiotic stress in plants	212
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	211
Science Twitter — navigating change in science communication	211
Migrasomes promote angiogenesis	200
The RNA world ‘hypothesis’	200
Improving chemical reprogramming strategies	193
FOXO transcription factors as mediators of stress adaptation	189
Context-dependent TGFβ family signalling in cell fate regulation	187
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	180
Splicing regulation through biomolecular condensates and membraneless organelles	178
Circadian clock communication during homeostasis and ageing	173
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	171
RNA binding — a useful third wheel in transcription	164
Like water on rock, the microenvironment bends stem cell fate	164
Subcellular localization as a driver of protein function	162
Mechanisms and regulation of the Hsp70 chaperone network	162
Energy-driven genome regulation by ATP-dependent chromatin remodellers	162
Activation of human endogenous retroviruses and its physiological consequences	161
Context-specific regulation and function of mRNA alternative polyadenylation	160
Mechanisms of mitochondrial respiratory adaptation	156
Does species-specific alternative splicing make us human?	151
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	147
Organelles stick together through PDZD8-mediated condensate formation	143
How ancient RNA survives and what we can learn from it	140

A guide to cell death pathways	133
Transcriptional control of energy metabolism by nuclear receptors	133
Regulation and function of insulin and insulin-like growth factor receptor signalling	129
Molecular machineries and pathways of mitochondrial protein transport	128
Targeted protein degradation: from mechanisms to clinic	126
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	122
Myosin VI assists in fork protection	122
The centromere as a tag of self-DNA	121
Cold-induced longevity through proteasome boosting	118
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	116
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	115
New frontiers in quality control: the case of GPI-anchored proteins	110
Decoding ubiquitin signals inside cells	109
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	105
The molecular basis for cellular function of intrinsically disordered protein regions	103
Redox-driven cell death by disulfidptosis and its therapeutic potential	100
DEI conversations: more than a box-ticking exercise	96
The technological landscape and applications of single-cell multi-omics	96
Microenvironmental determinants of endothelial cell heterogeneity	96
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	94
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	93
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	91
Anticancer effects of zotatifin are mediated by RNA structure remodelling	91
Genome characteristics at the borders	91
The role and regulation of integrins in cell migration and invasion	88
Fat cells have long-lasting (epigenetic) memory	88
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	88
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	83
Unravelling oocyte ultrastructure	82
Profiling the disordered proteome in cells using a chemical tag	80
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	80
The contribution of databases towards understanding the universe of long non-coding RNAs	78
The hunter becomes the hunted in target-directed microRNA degradation	78
Transcription factors crossing the cell membrane	77
From shortening telomeres to replicative crisis	75
Neural crest gene regulatory networks as drivers of development, diversification and disease	75
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	73
Ethylene — the lifeguard hormone	69
How green is your science? The race to make laboratories sustainable	68
Exercise metabolism and adaptation in skeletal muscle	64
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	64
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	63
Mechanisms and regulation of substrate degradation by the 26S proteasome	63
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	62
Translation feedback control in the brain	61
Cellular role of TETs in early embryos	61
Cis-regulatory elements that tune transcriptional responses in liver drug metabolism and outcomes	52
Following the electric current	51
Stem cell sources of colon cancer in mice	50
Author Correction: The role of the haematopoietic stem cell niche in development and ageing	47
Organization of replicated chromosomes by DNA loops and sister chromatid cohesion	45
Overcoming cytoskeleton instability in the early embryo	45
Publisher Correction: Advancing single-cell omics and cell-based therapeutics with quantum computing	42
The senescence-associated secretory phenotype and its physiological and pathological implications	41
Cellular and molecular control of vertebrate somitogenesis	40
Calcium connects lysosomal damage to stress granule formation	39
The birth of evo-devo	39
The bioethics of synthetic cells	38
SWI/SNF chromatin remodellers persist through mitosis	38
Tissue injury leads to the accumulation of somatic mtDNA mutations	36
Deciphering ADP-ribosylation signalling	35
The bystander effect of pyroptosis	34
Collective cell migration modes in development, tissue repair and cancer	33
Nuclear speckles of GC richness	33
Mediat(or)ing adult stem cells by XIST	32
Mechanisms and regulation of DNA end resection in the maintenance of genome stability	32
Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking	29
Local and systemic mechanisms that control the hair follicle stem cell niche	29
The mechanistic basis and cellular functions of UFMylation	27
Present and future of synthetic cell development	27
Mechanical state transitions in the regulation of tissue form and function	27
Functions and therapeutic applications of pseudouridylation	25
Spatiotemporal control over cell–matrix interactions using dynamic micropatterns	24
Harnessing fluorescent probes to unveil dynamic membrane mechanics	24
Voices of the new generation: my unconventional way to stay in academia	22
ncRNA regulation of mitochondrial transcription	22
Microtubules provide a mechanical link for YAP/TAZ signalling	22
The emergence of MARUbe — a hybrid ADP-ribose–ubiquitin modification	21
Proteins that assemble co-translationally lean on their partner for stability	21
Phase separation across membranes and condensates in cell organization and function	20

ERMES — from myths to molecules	19
Signalling mechanisms and cellular functions of SUMO	18
Sorting membrane proteins by size in the Golgi	18
Smelling your way to longevity	17
Lasker Award for AlphaFold	17
Epigenetic discovery by enzyme activity profiling	16
Regulation of RNA-binding proteins by small biomolecules	16
Internal-m7G-modified mRNAs quake under stress	16
Size matters	15
Decoding the interactions and functions of non-coding RNA with artificial intelligence	15
A nuclear morphology-based machine learning algorithm for senescence detection	15
Revealing the hidden coding potential of the human genome	15
Blebbisomes are one bleb away from a functional cell	15
Enabling RNA-compatible synthetic receptors through RNA editing	14
The birth of stable introns	14
Critical constituents and assembly principles of centriole biogenesis in human cells	13
Translating the midbody for cytokinesis	12
The nuance in DNA and transcription factor interactions	12
Early insights into co-translational assembly of protein complexes	12
The emerging importance of UBA6 in ubiquitylation and proteostasis	12
Mitochondrial ROS drive cell cycle progression	12
Cellular functions of eukaryotic RNA helicases and their links to human diseases	11
BCL-2 proteins in senescence: beyond a simple target for senolysis?	11
The discovery of cyclin-dependent kinases	11
New imprinting control-like regions	11
The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance	11
Mechanistic insights into gasdermin-mediated pyroptosis	10
Mechanisms and regulation of human mitochondrial transcription	10
Genome control by SMC complexes	10
Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target	10
Viruses show the way	10
Prevailing views of cell senescence overlook its biological complexity	10
Towards a unified framework for the function of endoplasmic reticulum exit sites	9
Monitoring subcellular protein localization at scale in live cells	9
Shaping epithelial tissues by stem cell mechanics in development and cancer	8
Single-cell lipidomics reveals the organizing principle of cell fate decision	8
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing	8
Paleoproteomics sheds light on million-year-old fossils	8
Publisher Correction: Mechanisms and regulation of the Hsp70 chaperone network	8
A novel photosystem assembly line worker	7
Author Correction: Fundamentals of redox regulation in biology	7
Exploring the uncharted landscape of truncated mRNAs	7
Cell–extracellular matrix mechanotransduction in 3D	7
Protrusion-derived vesicles: new subtype of EVs?	6
Mechanics and functional consequences of nuclear deformations	6
Key challenges and recommendations for defining organelle membrane contact sites	6
The double-edged sword of bivalency	6
Author Correction: Molecular machineries and pathways of mitochondrial protein transport	6
The lipotype hypothesis	6
Heterogeneity, dynamics and organelle interactions of lipid droplets	6
Uncovering mRNA sequences that control translation initiation	6
Modes of Notch signalling in development and disease	6
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation	6
Principles and dynamics of spindle assembly checkpoint signalling	6
Modelling human brain development and disease with organoids	6
The role of the haematopoietic stem cell niche in development and ageing	5
Illuminating protein microenvironments with rotor-based fluorescent amino acids	5
Condensates trail the nucleus	5
Base editing of organellar DNA with programmable deaminases	5
Turning the replisome around	5
Probing cytoskeletal remodelling by cutting and marking filaments	5
DNA modifications walk a fine line between epigenetics and mutagenesis	5
How embryos sort themselves out	5
The prompt to discover senolytics	4
The memory of viscosity	4
Regulation and functions of non-m6A mRNA modifications	4
A histone code controls positional identity in limb regeneration	4
Challenges and opportunities in macromolecular structure determination	4
Inflammageing and clonal haematopoiesis interplay and their impact on human disease	4
Regulation of and challenges in targeting NAD+ metabolism	4
A catalytic function for mammalian Argonautes	4
Molecular machineries shaping the mitochondrial inner membrane	4
Mechanisms of mechanotransduction and physiological roles of PIEZO channels	4
The regulation, function and disease relevance of cytoplasmic tRNAs	4
The multiple links between actin and mitochondria	3
Biochemical and mechanical regulation of actin dynamics	3
Good neighbours transfer nucleotides	3
Mechanisms and functions of protein S-acylation	3
The discovery of simple repeats that cause complex disorders	3
A lunapark for secretory mRNA translation at ER junctions	3
Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer	3
Distal enhancers loop to proximal enhancers, not to promoters	3
Uncovering the complexity of RNA–protein interactions	3
Plant hormone regulation of abiotic stress responses	3
Modelling tauopathies	3
Genome doubling — twice the same is not the same	3
Fatty acid signalling promotes hair regrowth	3
RNF26 and vimentin orchestrate ER stress recovery	3
Plant microRNA maturation and function	3
Cell quiescence sends argonaute-2 to transposons	3
White adipocyte dysfunction and obesity-associated pathologies in humans	3
Senescent cells support limb regeneration	3
The neuronal epigenome is special	3
SLAM passes the haematopoietic stem cell identity test	3