Nature Reviews Molecular Cell Biology

Article	Citations
Ferroptosis: mechanisms, biology and role in disease	3069
Gene regulation by long non-coding RNAs and its biological functions	2757
Mechanisms of SARS-CoV-2 entry into cells	1853
Cellular senescence in ageing: from mechanisms to therapeutic opportunities	1040
A guide to machine learning for biologists	856
Reactive oxygen species signalling in plant stress responses	773
NAD+ metabolism and its roles in cellular processes during ageing	719
Long non-coding RNAs: definitions, functions, challenges and recommendations	693
Cell cycle control in cancer	687
Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing	679
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology	676
A framework for understanding the functions of biomolecular condensates across scales	537
Challenges and directions in studying cell–cell communication by extracellular vesicles	527
Plant hormone regulation of abiotic stress responses	464
The assembly, regulation and function of the mitochondrial respiratory chain	386
The expanding world of tRNA modifications and their disease relevance	371
The principles of directed cell migration	345
Molecular mechanisms of dietary restriction promoting health and longevity	345
Modulation of cellular processes by histone and non-histone protein acetylation	344
The mechanisms and roles of selective autophagy in mammals	338
Genome folding through loop extrusion by SMC complexes	328
Mechanisms controlling pancreatic islet cell function in insulin secretion	327
Diversity and versatility of p38 kinase signalling in health and disease	315
Autophagy and autophagy-related pathways in cancer	305
The aetiology and molecular landscape of insulin resistance	301

Machinery, regulation and pathophysiological implications of autophagosome maturation	284
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design	278
New insights into activation and function of the AMPK	264
The cellular and functional complexity of thermogenic fat	261
The molecular principles of gene regulation by Polycomb repressive complexes	256
Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression	247
Molecular mechanisms and consequences of mitochondrial permeability transition	243
The roles of Polycomb repressive complexes in mammalian development and cancer	238
Understanding 3D genome organization by multidisciplinary methods	232
Crosstalk between mechanotransduction and metabolism	230
Direct cell reprogramming: approaches, mechanisms and progress	214
Mechanisms and regulation of protein synthesis in mitochondria	210
Context-specific regulation of extracellular vesicle biogenesis and cargo selection	210
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	204
Regulation of membrane protein structure and function by their lipid nano-environment	200
Intracellular mRNA transport and localized translation	199
The technological landscape and applications of single-cell multi-omics	198
Roles of transposable elements in the regulation of mammalian transcription	197
MicroRNA-mediated regulation of glucose and lipid metabolism	195
Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	195
Molecular mechanisms underlying nucleotide repeat expansion disorders	194
Cellular origins of dsRNA, their recognition and consequences	186
Control of satellite cell function in muscle regeneration and its disruption in ageing	186
Programmed and self-organized flow of information during morphogenesis	184
Human topoisomerases and their roles in genome stability and organization	183
Mechanics and functional consequences of nuclear deformations	181
A guide to membraneless organelles and their various roles in gene regulation	180
Phosphoinositides as membrane organizers	167
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	165
Nuclear compartmentalization as a mechanism of quantitative control of gene expression	164
The physiology of alternative splicing	161
Cell–extracellular matrix mechanotransduction in 3D	158
Regulation of microtubule dynamics, mechanics and function through the growing tip	157
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization	154
Causes and consequences of RNA polymerase II stalling during transcript elongation	151
The emerging mechanisms and functions of microautophagy	150
Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions	149
Signalling mechanisms and cellular functions of SUMO	145
Liver regeneration and inflammation: from fundamental science to clinical applications	145
An expanded lexicon for the ubiquitin code	142
Cellular functions of the protein kinase ATM and their relevance to human disease	136
Mechanisms controlling cellular and systemic iron homeostasis	136
Karyopherin-mediated nucleocytoplasmic transport	135
Pioneer factors as master regulators of the epigenome and cell fate	130
Context-specific regulation and function of mRNA alternative polyadenylation	128
The mechanisms of integral membrane protein biogenesis	128
Ageing and rejuvenation of tissue stem cells and their niches	128
Apical–basal polarity and the control of epithelial form and function	127
Biochemical and mechanical regulation of actin dynamics	127
Mechanisms of BCL-2 family proteins in mitochondrial apoptosis	124

Gene regulation in time and space during X-chromosome inactivation	117
The Mediator complex as a master regulator of transcription by RNA polymerase II	115
Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining	115
Roles of RNA silencing in viral and non-viral plant immunity and in the crosstalk between disease resistance systems	110
Metabolites as signalling molecules	106
Interplay between mechanics and signalling in regulating cell fate	99
Mechanisms of mitochondrial respiratory adaptation	98
The molecular basis for cellular function of intrinsically disordered protein regions	96
Emerging roles and functional mechanisms of PIWI-interacting RNAs	95
Understanding mechanisms of antioxidant action in health and disease	94
Plant and animal small RNA communications between cells and organisms	90
Regulation of axonal regeneration after mammalian spinal cord injury	86
Ubiquitin ligases: guardians of mammalian development	85
Principles and dynamics of spindle assembly checkpoint signalling	84
Selective motor activation in organelle transport along axons	83
Mechanisms of microtubule organization in differentiated animal cells	82
Regulation, functions and transmission of bivalent chromatin during mammalian development	81
Translational control of stem cell function	78
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	75
Biology and therapeutic targeting of vascular endothelial growth factor A	75
Mechanisms and roles of podosomes and invadopodia	73
Author Correction: Gene regulation by long non-coding RNAs and its biological functions	73
Regulation and functions of non-m6A mRNA modifications	71
Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins	69
Endocytosis in the context-dependent regulation of individual and collective cell properties	69
A guide to cell death pathways	67
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	67
Molecular and cellular basis of genetically inherited skeletal muscle disorders	65
Spindle positioning and its impact on vertebrate tissue architecture and cell fate	64
Aneuploidy in mammalian oocytes and the impact of maternal ageing	62
Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity	59
Mechanical regulation of early vertebrate embryogenesis	57
Exercise metabolism and adaptation in skeletal muscle	56
Transcriptional control of energy metabolism by nuclear receptors	56
Effects of aneuploidy on cell behaviour and function	56
The cell biology of ferroptosis	55
Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases	55
Cellular and molecular mechanisms of Hedgehog signalling	52
Deep learning shapes single-cell data analysis	51
Cellular and molecular mechanisms of skin wound healing	49
Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes	48
Cytoskeletal control of early mammalian development	46
Generation of nanoscopic membrane curvature for membrane trafficking	46
Cell competition in development, homeostasis and cancer	45
Mechanisms and pathology of protein misfolding and aggregation	45
Cellular functions of eukaryotic RNA helicases and their links to human diseases	44
Mechanisms of substrate processing during ER-associated protein degradation	44
Genome control by SMC complexes	43
Structural and functional complexity of HSP90 in cellular homeostasis and disease	42
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology	42
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	42
Metabolic regulation of somatic stem cells in vivo	39
The many regulators of epithelial−mesenchymal transition	37
The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease	36
Identification of non-coding silencer elements and their regulation of gene expression	32
Keeping chromatin in the loop(s)	32
Structure and growth of plant cell walls	32
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	32
Transcriptional networks controlling stromal cell differentiation	32
The molecular basis of translation initiation and its regulation in eukaryotes	31
Transcription regulation by long non-coding RNAs: mechanisms and disease relevance	29
Control of stem cell renewal and fate by YAP and TAZ	27
Mechanisms of SNARE proteins in membrane fusion	26
The multiple links between actin and mitochondria	25
Mechanisms underlying spindle assembly and robustness	25
CRISPR technologies for genome, epigenome and transcriptome editing	25
FOXO transcription factors as mediators of stress adaptation	23
Mechanisms and functions of protein S-acylation	22
Adherens junctions as molecular regulators of emergent tissue mechanics	22
The nature of blood(y) extracellular vesicles	20
The senescence-associated secretory phenotype and its physiological and pathological implications	20
Activation of human endogenous retroviruses and its physiological consequences	19
Targeted protein degradation: from mechanisms to clinic	18
Mechanisms and regulation of human mitochondrial transcription	17
Mitochondrial ROS drive cell cycle progression	17
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	17
The role of ordered cooperative assembly in biomolecular condensates	17
Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition	17
RNA polymerase II transcription compartments: from multivalent chromatin binding to liquid droplet formation?	16
White adipocyte dysfunction and obesity-associated pathologies in humans	16

Patterning of the cell cortex by Rho GTPases	16
Revisiting small RNA movement in plants	15
Fundamentals of redox regulation in biology	15
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation	15
Let’s talk about (biological) sex	15
The prospects and opportunities of protein structure prediction with AI	15
Opportunities and challenges in design and optimization of protein function	14
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	14
Defining the functions of PIWI-interacting RNAs	14
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	13
Publisher Correction: Plant hormone regulation of abiotic stress responses	13
Context-dependent TGFβ family signalling in cell fate regulation	13
Heterochromatin definition and function	13
SenNet recommendations for detecting senescent cells in different tissues	11
Emerging mechanistic understanding of cilia function in cellular signalling	11
Energy-driven genome regulation by ATP-dependent chromatin remodellers	11
Live-cell imaging powered by computation	10
Author Correction: Molecular mechanisms underlying nucleotide repeat expansion disorders	10
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	10
Local and systemic mechanisms that control the hair follicle stem cell niche	10
Solutes as controllers of endomembrane dynamics	10
Base editing of organellar DNA with programmable deaminases	9
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	9
Mitochondrial proteome research: the road ahead	9
Author Correction: Applications of CRISPR–Cas in agriculture and plant biotechnology	9
Present and future of synthetic cell development	8
The contribution of databases towards understanding the universe of long non-coding RNAs	8
How the α-helix got its name	8
Making more exosomes	8
How green is your science? The race to make laboratories sustainable	8
Science Twitter — navigating change in science communication	7
mRNA translation in stress granules is not uncommon	7
Protrusion-derived vesicles: new subtype of EVs?	7
Migrasomes promote angiogenesis	7
Publisher Correction: Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization	7
Why novel mRNA modifications are so challenging and what we can do about it	7
Imaging DNA double-strand breaks — are we there yet?	7
The lipotype hypothesis	6
Roles and regulation of tRNA-derived small RNAs in animals	6
Die hard: resilient RNAs in the blood	6
The RNA world ‘hypothesis’	6
Uncovering SARS-CoV-2 kidney tropism	6
Cellular and molecular control of vertebrate somitogenesis	6
Intermittent fasting is gaining interest fast	6
Co-transcriptional gene regulation in eukaryotes and prokaryotes	5
Single-cell lipidomics reveals the organizing principle of cell fate decision	5
Protein N-terminal acetylation is entering the degradation end game	5
Human pluripotent stem cells: derivation and applications	5
microRNA communication in plants	5
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	5
Author Correction: Intracellular mRNA transport and localized translation	5
BCL-2 proteins in senescence: beyond a simple target for senolysis?	5
New guidelines for embryo and stem cell research	5
Publisher Correction: Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	4
EVs promote stemness	4
Sorting out microtubule-based transport	4
Lysosome transport interrupted	4
Persisting through apoptosis	4
Author Correction: Mitochondrial proteins: from biogenesis to functional networks	4
Engineering cellular symphonies out of transcriptional noise	4
Who did what: changing how science papers are written to detail author contributions	4
Transfection reflections: fit-for-purpose delivery of nucleic acids	4
Mechanical state transitions in the regulation of tissue form and function	4
DNA modifications walk a fine line between epigenetics and mutagenesis	4
How m6A makes its mark	4
A mistranslation-prone transcriptome underlying polyglutamine expansion diseases	4
First demonstration of miRNA-dependent mRNA decay	4
Damaged mitochondria are discarded via migrasomes	4
Cellular basis for SARS-CoV-2 infection	4
Publisher Correction: Reading, writing and erasing mRNA methylation	4
Author Correction: The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease	4
Shaping the stem cell field	4
Mesoscale organization in bacteria	3
Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer	3
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	3
Spot in a drop: mutations in aberrant condensates	3
New frontiers in quality control: the case of GPI-anchored proteins	3
RAG-ulating mTORC1 with amino acids	3
Identification of metabolic networks by genetic co-essentiality analysis	3
The double-edged sword of bivalency	2
First prediction of sequence-specific recognition of double-helix nucleic acids by proteins	2
Studying lysosomal function and dysfunction using LysoIP	2
m6A nuclear condensates support AML	2
Regulation of cellular and systemic sphingolipid homeostasis	2
The birth of evo-devo	2
Mechanism of pathogen-induced cap-independent translation in plants	2
The healing role of gasdermin B in IBD	2
ATP and ROS signal cell extrusion	2
Transitioning through the continuum of differentiation	2
The memory of viscosity	2
Splicing regulation through biomolecular condensates and membraneless organelles	2
Pitfalls in lipid mass spectrometry of mammalian samples — a brief guide for biologists	2
Ethylene — the lifeguard hormone	2
Has translation in the nucleus found its purpose?	2
Targeting viruses in their phase	2