Nature Reviews Molecular Cell Biology

Article	Citations
The translation m(o)TOR that propels regeneration	2433
When senescence generates pluripotent stem cells	1422
A dynamic culture system that models the intricacy of the mammary gland	1376
From trans-splicing discovery and onwards, trypanosomes lead the way	1372
Re-sizing of nuclear pores	1146
Histone H1 deamidation regulates DNA double-strand break repair	1047
Tightening the epithelium to control signalling	851
Transfection reflections: fit-for-purpose delivery of nucleic acids	847
DNA-repair-driven cell death compels us to rethink cancer therapies	832
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	651
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	641
Understanding mechanisms of antioxidant action in health and disease	602
Mechanisms of substrate processing during ER-associated protein degradation	599
Modulation of cellular processes by histone and non-histone protein acetylation	581
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	556
Chemical reprogramming of human blood cells	525
How proteins sense their cellular environment	519
Mechanism and regulation of kinesin motors	441
Resilience through selective translation	433
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	424
N-glycan-dependent protein maturation and quality control in the ER	391
Decoding the Ca2+ signal for salt tolerance	390
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	382
Publisher Correction: Plant hormone regulation of abiotic stress responses	370
New insights into activation and function of the AMPK	361

The emerging mechanisms and functions of microautophagy	355
The healing role of gasdermin B in IBD	354
C-degron mimicry confers E3 ligase selectivity	346
Bookmarking pluripotency genes	341
Silencing centromeres with age	332
The discovery of oncogene-induced senescence	328
Nucleosomes as blueprints of genome architecture	325
Studying lysosomal function and dysfunction using LysoIP	324
Regulation, functions and transmission of bivalent chromatin during mammalian development	312
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	312
Mechanisms and roles of podosomes and invadopodia	311
CRISPR–Cas applications in agriculture and plant research	307
Telomere function and regulation from mouse models to human ageing and disease	305
Biology and therapeutic targeting of vascular endothelial growth factor A	293
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design	290
Regulation of membrane protein structure and function by their lipid nano-environment	274
Curvature-mediated endocytosis	262
Molecular tools for analysing in vivo senescence	261
Big cells, small potential	261
A quick guide to (transmembrane) planar cell polarity mouse strains	250
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	242
Science Twitter — navigating change in science communication	236
Context-dependent TGFβ family signalling in cell fate regulation	227
Migrasomes promote angiogenesis	225
Improving chemical reprogramming strategies	220
The prospects and opportunities of protein structure prediction with AI	212
A histone variant that manages abiotic stress in plants	207
Snoozing APC/C for a sweet cell cycle entry	206
Splicing regulation through biomolecular condensates and membraneless organelles	195
Circadian clock communication during homeostasis and ageing	187
FOXO transcription factors as mediators of stress adaptation	184
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	183
Molecular mechanisms and consequences of mitochondrial permeability transition	183
The RNA world ‘hypothesis’	182
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	179
Why novel mRNA modifications are so challenging and what we can do about it	178
Transposons: catch them if you can	175
RNA binding — a useful third wheel in transcription	175
New tool for MAPping microtubule dynamics	174
Activation of human endogenous retroviruses and its physiological consequences	162
Mechanisms of mitochondrial respiratory adaptation	162
Context-specific regulation and function of mRNA alternative polyadenylation	160
Energy-driven genome regulation by ATP-dependent chromatin remodellers	157
Does species-specific alternative splicing make us human?	154
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	153
Transcriptional control of energy metabolism by nuclear receptors	152
How ancient RNA survives and what we can learn from it	151
Revisiting small RNA movement in plants	149
Apical–basal polarity and the control of epithelial form and function	148
Molecular machineries and pathways of mitochondrial protein transport	136

Regulation and function of insulin and insulin-like growth factor receptor signalling	134
Targeted protein degradation: from mechanisms to clinic	129
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	127
A guide to cell death pathways	126
Cold-induced longevity through proteasome boosting	125
Myosin VI assists in fork protection	125
New frontiers in quality control: the case of GPI-anchored proteins	124
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	123
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	117
The centromere as a tag of self-DNA	117
Redox-driven cell death by disulfidptosis and its therapeutic potential	110
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	109
The technological landscape and applications of single-cell multi-omics	108
The molecular basis for cellular function of intrinsically disordered protein regions	102
DEI conversations: more than a box-ticking exercise	102
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	96
Fat cells have long-lasting (epigenetic) memory	95
Genome characteristics at the borders	94
Anticancer effects of zotatifin are mediated by RNA structure remodelling	93
ATP and ROS signal cell extrusion	93
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	92
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	92
Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition	92
Microenvironmental determinants of endothelial cell heterogeneity	91
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	90
The role and regulation of integrins in cell migration and invasion	89
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	88
Mechanisms of microtubule organization in differentiated animal cells	87
Deep learning shapes single-cell data analysis	86
Interplay between mechanics and signalling in regulating cell fate	84
Sleep tight thanks to Parp1	83
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	82
Ethylene — the lifeguard hormone	82
Unravelling oocyte ultrastructure	80
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	76
From shortening telomeres to replicative crisis	75
The contribution of databases towards understanding the universe of long non-coding RNAs	74
Profiling the disordered proteome in cells using a chemical tag	74
Transcription factors crossing the cell membrane	74
How green is your science? The race to make laboratories sustainable	71
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	69
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	68
Mechanisms and regulation of substrate degradation by the 26S proteasome	59
The many regulators of epithelial−mesenchymal transition	58
Karyopherin-mediated nucleocytoplasmic transport	57
Exercise metabolism and adaptation in skeletal muscle	55
Mechanisms of SARS-CoV-2 entry into cells	55
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	55
EV signalling in the haematopoietic niche	54
Cellular role of TETs in early embryos	53
Author Correction: The role of the haematopoietic stem cell niche in development and ageing	50
Translation feedback control in the brain	50
Following the electric current	48
Cellular and molecular control of vertebrate somitogenesis	46
The birth of evo-devo	41
The senescence-associated secretory phenotype and its physiological and pathological implications	41
Deciphering ADP-ribosylation signalling	38
SWI/SNF chromatin remodellers persist through mitosis	38
The bystander effect of pyroptosis	37
Calcium connects lysosomal damage to stress granule formation	37
The bioethics of synthetic cells	37
Collective migration modes in development, tissue repair and cancer	36
Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking	34
Mechanisms and regulation of DNA end resection in the maintenance of genome stability	34
Mediat(or)ing adult stem cells by XIST	34
Voices of the new generation: my unconventional way to stay in academia	33
Harnessing fluorescent probes to unveil dynamic membrane mechanics	31
ERMES — from myths to molecules	30
ncRNA regulation of mitochondrial transcription	29
Proteins that assemble co-translationally lean on their partner for stability	29
Functions and therapeutic applications of pseudouridylation	28
Spatiotemporal control over cell–matrix interactions using dynamic micropatterns	28
Mechanical state transitions in the regulation of tissue form and function	27
Present and future of synthetic cell development	26
Local and systemic mechanisms that control the hair follicle stem cell niche	26
Signalling mechanisms and cellular functions of SUMO	26
Smelling your way to longevity	25
Sorting membrane proteins by size in the Golgi	23
Epigenetic discovery by enzyme activity profiling	23
Blebbisomes are one bleb away from a functional cell	21

Let’s talk about (biological) sex	21
Decoding the interactions and functions of non-coding RNA with artificial intelligence	20
The nuance in DNA and transcription factor interactions	20
Internal-m7G-modified mRNAs quake under stress	20
A nuclear morphology-based machine learning algorithm for senescence detection	20
Lasker Award for AlphaFold	20
Size matters	19
Translating the midbody for cytokinesis	17
The birth of stable introns	17
Early insights into co-translational assembly of protein complexes	16
Enabling RNA-compatible synthetic receptors through RNA editing	15
Mitochondrial ROS drive cell cycle progression	15
Control of satellite cell function in muscle regeneration and its disruption in ageing	14
The discovery of cyclin-dependent kinases	13
Mapping organelle supply chains	13
Cellular functions of eukaryotic RNA helicases and their links to human diseases	13
Mechanisms and regulation of human mitochondrial transcription	12
New imprinting control-like regions	12
Pioneer factors as master regulators of the epigenome and cell fate	11
Genome control by SMC complexes	11
5mC: what goes on must come off	11
BCL-2 proteins in senescence: beyond a simple target for senolysis?	11
Mechanistic insights into gasdermin-mediated pyroptosis	11
Monitoring subcellular protein localization at scale in live cells	10
Author Correction: Fundamentals of redox regulation in biology	10
Effects of aneuploidy on cell behaviour and function	10
Single-cell lipidomics reveals the organizing principle of cell fate decision	10
Gene regulation in time and space during X-chromosome inactivation	10
Viruses show the way	10
Paleoproteomics sheds light on million-year-old fossils	9
Shaping epithelial tissues by stem cell mechanics in development and cancer	9
Cell–extracellular matrix mechanotransduction in 3D	9
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing	9
Exploring the uncharted landscape of truncated mRNAs	9
Returning to the lab after a career break	8
oskar stands on solid ground for translation	8
The double-edged sword of bivalency	8
Protrusion-derived vesicles: new subtype of EVs?	8
A novel photosystem assembly line worker	8
The lipotype hypothesis	7
Modelling human brain development and disease with organoids	7
Author Correction: Molecular machineries and pathways of mitochondrial protein transport	7
Modes of Notch signalling in development and disease	7
Key challenges and recommendations for defining organelle membrane contact sites	7
Principles and dynamics of spindle assembly checkpoint signalling	7
Uncovering mRNA sequences that control translation initiation	7
The role of the haematopoietic stem cell niche in development and ageing	6
A catalytic function for mammalian Argonautes	6
Compression as a driver of hair loss	6
Probing cytoskeletal remodelling by cutting and marking filaments	6
Mechanics and functional consequences of nuclear deformations	6
Condensates trail the nucleus	6
How embryos sort themselves out	6
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation	6
The prompt to discover senolytics	5
A histone code controls positional identity in limb regeneration	5
Challenges and opportunities in macromolecular structure determination	5
The memory of viscosity	5
Molecular machineries shaping the mitochondrial inner membrane	4
Mechanisms of mechanotransduction and physiological roles of PIEZO channels	4
Regulation of and challenges in targeting NAD+ metabolism	4
DNA modifications walk a fine line between epigenetics and mutagenesis	4
Regulation and functions of non-m6A mRNA modifications	4
Senescent cells support limb regeneration	4
Base editing of organellar DNA with programmable deaminases	4
A guide to machine learning for biologists	4
The neuronal epigenome is special	4
RNF26 and vimentin orchestrate ER stress recovery	3
MYC in TOP shape	3
The multiple links between actin and mitochondria	3
Modelling tauopathies	3
Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer	3
The discovery of simple repeats that cause complex disorders	3
Plant microRNA maturation and function	3
Distal enhancers loop to proximal enhancers, not to promoters	3
Genome doubling — twice the same is not the same	3
Uncovering the complexity of RNA–protein interactions	3
Good neighbours transfer nucleotides	3
Cell quiescence sends argonaute-2 to transposons	3
oskar switches motors halfway through its journey	2
Structural variation in COOLAIR lncRNA driven by cold	2
Rapid evolution to preserve a conserved function	2
Seeing the smallest rotary biomotor	2
RPA dynamics at telomeres	2
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics	2
Mechanisms and functions of protein S-acylation	2
A redox–auxin connection in response to water deficit	2
Hypoxia prevents premature ageing in mice	2
The diffraction limit of light taken by storm	2
Dodging mitochondrial mislocalization	2
Single-cell live volume measurements using the fluorescence exclusion method	2
A guide to membraneless organelles and their various roles in gene regulation	2
Long-lived proteomes in healthy ovaries	2
Condensates burst the bridge for transcription	2
Amyloids as kinase signalling platforms	2