Nature Reviews Molecular Cell Biology

Article	Citations
The translation m(o)TOR that propels regeneration	2395
When senescence generates pluripotent stem cells	1344
Transfection reflections: fit-for-purpose delivery of nucleic acids	1320
A dynamic culture system that models the intricacy of the mammary gland	1310
From trans-splicing discovery and onwards, trypanosomes lead the way	1105
Re-sizing of nuclear pores	1020
Histone H1 deamidation regulates DNA double-strand break repair	812
Tightening the epithelium to control signalling	811
Modulation of cellular processes by histone and non-histone protein acetylation	805
Understanding mechanisms of antioxidant action in health and disease	630
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	621
DNA-repair-driven cell death compels us to rethink cancer therapies	579
Mechanisms of substrate processing during ER-associated protein degradation	561
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	551
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	504
Publisher Correction: Plant hormone regulation of abiotic stress responses	499
Resilience through selective translation	454
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	419
How proteins sense their cellular environment	410
N-glycan-dependent protein maturation and quality control in the ER	384
Decoding the Ca2+ signal for salt tolerance	381
New insights into activation and function of the AMPK	369
Mechanism and regulation of kinesin motors	362
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	360
The emerging mechanisms and functions of microautophagy	357

The healing role of gasdermin B in IBD	346
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	344
Mechanisms and roles of podosomes and invadopodia	339
C-degron mimicry confers E3 ligase selectivity	335
Bookmarking pluripotency genes	320
Silencing centromeres with age	317
Voices of the new generation: open science is good for science (and for you)	314
The discovery of oncogene-induced senescence	309
Nucleosomes as blueprints of genome architecture	301
Studying lysosomal function and dysfunction using LysoIP	300
Regulation, functions and transmission of bivalent chromatin during mammalian development	299
CRISPR–Cas applications in agriculture and plant research	296
Biology and therapeutic targeting of vascular endothelial growth factor A	294
Telomere function and regulation from mouse models to human ageing and disease	291
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design	284
Regulation of membrane protein structure and function by their lipid nano-environment	281
Curvature-mediated endocytosis	263
Big cells, small potential	253
Molecular tools for analysing in vivo senescence	252
A quick guide to (transmembrane) planar cell polarity mouse strains	248
The RNA world ‘hypothesis’	239
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	223
Migrasomes promote angiogenesis	222
Improving chemical reprogramming strategies	221
The prospects and opportunities of protein structure prediction with AI	215
Why novel mRNA modifications are so challenging and what we can do about it	214
FOXO transcription factors as mediators of stress adaptation	213
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	208
Circadian clock communication during homeostasis and ageing	204
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	203
Science Twitter — navigating change in science communication	201
Context-dependent TGFβ family signalling in cell fate regulation	200
Molecular mechanisms and consequences of mitochondrial permeability transition	188
Splicing regulation through biomolecular condensates and membraneless organelles	179
RNA binding — a useful third wheel in transcription	174
Transposons: catch them if you can	174
New tool for MAPping microtubule dynamics	170
Mechanisms of mitochondrial respiratory adaptation	170
Activation of human endogenous retroviruses and its physiological consequences	168
Context-specific regulation and function of mRNA alternative polyadenylation	167
Energy-driven genome regulation by ATP-dependent chromatin remodellers	167
Does species-specific alternative splicing make us human?	160
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	159
How ancient RNA survives and what we can learn from it	157
Regulation and function of insulin and insulin-like growth factor receptor signalling	157
Transcriptional control of energy metabolism by nuclear receptors	149
Apical–basal polarity and the control of epithelial form and function	146
Molecular machineries and pathways of mitochondrial protein transport	145
Revisiting small RNA movement in plants	143
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	141

Targeted protein degradation: from mechanisms to clinic	141
A guide to cell death pathways	140
Myosin VI assists in fork protection	139
Cold-induced longevity through proteasome boosting	131
New frontiers in quality control: the case of GPI-anchored proteins	128
The centromere as a tag of self-DNA	125
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	122
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	120
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	119
The technological landscape and applications of single-cell multi-omics	119
The molecular basis for cellular function of intrinsically disordered protein regions	118
DEI conversations: more than a box-ticking exercise	117
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	112
Fat cells have long-lasting (epigenetic) memory	108
Genome characteristics at the borders	105
ATP and ROS signal cell extrusion	101
Anticancer effects of zotatifin are mediated by RNA structure remodelling	96
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	94
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	92
Microenvironmental determinants of endothelial cell heterogeneity	92
Nuclear compartmentalization as a mechanism of quantitative control of gene expression	91
The role and regulation of integrins in cell migration and invasion	90
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	90
Mechanisms of microtubule organization in differentiated animal cells	88
Interplay between mechanics and signalling in regulating cell fate	86
Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition	85
Sleep tight thanks to Parp1	81
Deep learning shapes single-cell data analysis	81
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	81
Unravelling oocyte ultrastructure	79
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	79
Ethylene — the lifeguard hormone	79
From shortening telomeres to replicative crisis	78
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	78
Transcription factors crossing the cell membrane	75
The contribution of databases towards understanding the universe of long non-coding RNAs	75
Profiling the disordered proteome in cells using a chemical tag	73
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	72
How green is your science? The race to make laboratories sustainable	72
The many regulators of epithelial−mesenchymal transition	70
Mechanisms and regulation of substrate degradation by the 26S proteasome	68
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	65
The molecular principles of gene regulation by Polycomb repressive complexes	63
Exercise metabolism and adaptation in skeletal muscle	63
Karyopherin-mediated nucleocytoplasmic transport	61
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	59
Mechanisms of SARS-CoV-2 entry into cells	58
EV signalling in the haematopoietic niche	57
Cellular role of TETs in early embryos	54
Translation feedback control in the brain	53
Author Correction: The role of the haematopoietic stem cell niche in development and ageing	51
Following the electric current	50
Cellular and molecular control of vertebrate somitogenesis	49
The birth of evo-devo	48
The senescence-associated secretory phenotype and its physiological and pathological implications	48
Deciphering ADP-ribosylation signalling	48
SWI/SNF chromatin remodellers persist through mitosis	44
Calcium connects lysosomal damage to stress granule formation	39
The bystander effect of pyroptosis	39
The bioethics of synthetic cells	36
Collective migration modes in development, tissue repair and cancer	35
Mediat(or)ing adult stem cells by XIST	34
Keeping oocytes young	34
Mechanisms and regulation of DNA end resection in the maintenance of genome stability	34
Voices of the new generation: my unconventional way to stay in academia	33
Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking	33
ERMES — from myths to molecules	32
Harnessing fluorescent probes to unveil dynamic membrane mechanics	32
ncRNA regulation of mitochondrial transcription	30
Functions and therapeutic applications of pseudouridylation	29
Proteins that assemble co-translationally lean on their partner for stability	29
Spatiotemporal control over cell–matrix interactions using dynamic micropatterns	27
Present and future of synthetic cell development	26
Mechanical state transitions in the regulation of tissue form and function	25
Local and systemic mechanisms that control the hair follicle stem cell niche	25
Signalling mechanisms and cellular functions of SUMO	25
Smelling your way to longevity	24
Sorting membrane proteins by size in the Golgi	23
Blebbisomes are one bleb away from a functional cell	23
Epigenetic discovery by enzyme activity profiling	23

Lasker Award for AlphaFold	21
Decoding the interactions and functions of non-coding RNA with artificial intelligence	21
Let’s talk about (biological) sex	21
Internal-m7G-modified mRNAs quake under stress	20
A nuclear morphology-based machine learning algorithm for senescence detection	20
The nuance in DNA and transcription factor interactions	19
Early insights into co-translational assembly of protein complexes	18
The birth of stable introns	18
Size matters	18
Translating the midbody for cytokinesis	17
Mitochondrial ROS drive cell cycle progression	17
Cellular functions of eukaryotic RNA helicases and their links to human diseases	16
Enabling RNA-compatible synthetic receptors through RNA editing	16
Cellular functions of the protein kinase ATM and their relevance to human disease	16
Control of satellite cell function in muscle regeneration and its disruption in ageing	15
5mC: what goes on must come off	13
The discovery of cyclin-dependent kinases	13
Mapping organelle supply chains	13
New imprinting control-like regions	12
BCL-2 proteins in senescence: beyond a simple target for senolysis?	12
Mechanistic insights into gasdermin-mediated pyroptosis	11
Genome control by SMC complexes	11
Mechanisms and regulation of human mitochondrial transcription	11
Pioneer factors as master regulators of the epigenome and cell fate	10
Author Correction: Fundamentals of redox regulation in biology	10
Single-cell lipidomics reveals the organizing principle of cell fate decision	10
Viruses show the way	10
The role of ordered cooperative assembly in biomolecular condensates	9
Monitoring subcellular protein localization at scale in live cells	9
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing	8
Exploring the uncharted landscape of truncated mRNAs	8
The double-edged sword of bivalency	8
Shaping epithelial tissues by stem cell mechanics in development and cancer	8
Cell–extracellular matrix mechanotransduction in 3D	8
oskar stands on solid ground for translation	8
Effects of aneuploidy on cell behaviour and function	8
Gene regulation in time and space during X-chromosome inactivation	8
A novel photosystem assembly line worker	8
Paleoproteomics sheds light on million-year-old fossils	8
Key challenges and recommendations for defining organelle membrane contact sites	7
The lipotype hypothesis	7
Modes of Notch signalling in development and disease	7
Returning to the lab after a career break	7
Uncovering mRNA sequences that control translation initiation	7
Modelling human brain development and disease with organoids	7
Author Correction: Molecular machineries and pathways of mitochondrial protein transport	6
Mechanics and functional consequences of nuclear deformations	6
Principles and dynamics of spindle assembly checkpoint signalling	6
Protrusion-derived vesicles: new subtype of EVs?	6
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation	6
The role of the haematopoietic stem cell niche in development and ageing	6
Probing cytoskeletal remodelling by cutting and marking filaments	5
Compression as a driver of hair loss	5
A histone code controls positional identity in limb regeneration	5
A catalytic function for mammalian Argonautes	5
BERing transcriptional noise for cell plasticity	5
How embryos sort themselves out	5
Condensates trail the nucleus	5
Molecular machineries shaping the mitochondrial inner membrane	4
DNA modifications walk a fine line between epigenetics and mutagenesis	4
A guide to machine learning for biologists	4
Regulation of and challenges in targeting NAD+ metabolism	4
The memory of viscosity	4
The prompt to discover senolytics	4
Base editing of organellar DNA with programmable deaminases	4
Challenges and opportunities in macromolecular structure determination	4
Regulation and functions of non-m6A mRNA modifications	4
Mechanisms of mechanotransduction and physiological roles of PIEZO channels	4
Regulation of microtubule dynamics, mechanics and function through the growing tip	3
Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer	3
The discovery of simple repeats that cause complex disorders	3
Uncovering the complexity of RNA–protein interactions	3
Senescent cells support limb regeneration	3
MYC in TOP shape	3
RNF26 and vimentin orchestrate ER stress recovery	3
Modelling tauopathies	3
Genome doubling — twice the same is not the same	3
The neuronal epigenome is special	3
Cell quiescence sends argonaute-2 to transposons	3
White adipocyte dysfunction and obesity-associated pathologies in humans	3
Mechanisms of auxin action in plant growth and development	2
Seeing the smallest rotary biomotor	2
Amyloids as kinase signalling platforms	2
oskar switches motors halfway through its journey	2
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics	2
Condensates burst the bridge for transcription	2
The diffraction limit of light taken by storm	2
Heterochromatin as a balancing act between transcription and gene silencing	2
A guide to membraneless organelles and their various roles in gene regulation	2
RPA dynamics at telomeres	2
Plant hormone regulation of abiotic stress responses	2
A redox–auxin connection in response to water deficit	2
Single-cell live volume measurements using the fluorescence exclusion method	2
Dodging mitochondrial mislocalization	2
Control of stem cell renewal and fate by YAP and TAZ	2