Nature Reviews Molecular Cell Biology

Article	Citations
When senescence generates pluripotent stem cells	1577
The translation m(o)TOR that propels regeneration	1520
Re-sizing of nuclear pores	1244
From trans-splicing discovery and onwards, trypanosomes lead the way	941
A dynamic culture system that models the intricacy of the mammary gland	927
The secretory pathway gets a molecular framework	887
Mechanisms of substrate processing during ER-associated protein degradation	718
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	711
Tightening the epithelium to control signalling	665
DNA-repair-driven cell death compels us to rethink cancer therapies	665
Histone H1 deamidation regulates DNA double-strand break repair	638
Transfection reflections: fit-for-purpose delivery of nucleic acids	636
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	500
Modulation of cellular processes by histone and non-histone protein acetylation	496
Understanding mechanisms of antioxidant action in health and disease	488
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	446
Decoding the Ca2+ signal for salt tolerance	417
The double life of a transcription factor in the cytoplasm	405
Chemical reprogramming of human blood cells	404
Resilience through selective translation	401
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	391
How proteins sense their cellular environment	386
The advent of confocal laser scanning microscopy in biological research	386
N-glycan-dependent protein maturation and quality control in the ER	380
Publisher Correction: Plant hormone regulation of abiotic stress responses	364

Mechanism and regulation of kinesin motors	362
New insights into activation and function of the AMPK	341
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	341
The emerging mechanisms and functions of microautophagy	338
The healing role of gasdermin B in IBD	334
C-degron mimicry confers E3 ligase selectivity	332
Coordination of cardiogenesis in vivo and in vitro	317
Nucleosomes as blueprints of genome architecture	313
Studying lysosomal function and dysfunction using LysoIP	312
Bookmarking pluripotency genes	302
Silencing centromeres with age	301
The discovery of oncogene-induced senescence	281
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	275
Mechanisms and roles of podosomes and invadopodia	273
Regulation, functions and transmission of bivalent chromatin during mammalian development	269
CRISPR–Cas applications in agriculture and plant research	243
Regulation of membrane protein structure and function by their lipid nano-environment	240
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design	238
Telomere function and regulation from mouse models to human ageing and disease	230
Biology and therapeutic targeting of vascular endothelial growth factor A	228
Curvature-mediated endocytosis	220
Big cells, small potential	216
Molecular tools for analysing in vivo senescence	210
A quick guide to (transmembrane) planar cell polarity mouse strains	208
Improving chemical reprogramming strategies	205
Snoozing APC/C for a sweet cell cycle entry	204
A histone variant that manages abiotic stress in plants	202
Why novel mRNA modifications are so challenging and what we can do about it	198
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	195
Migrasomes promote angiogenesis	193
Science Twitter — navigating change in science communication	191
Context-dependent TGFβ family signalling in cell fate regulation	191
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	184
The RNA world ‘hypothesis’	183
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	181
Circadian clock communication during homeostasis and ageing	174
Molecular mechanisms and consequences of mitochondrial permeability transition	169
The prospects and opportunities of protein structure prediction with AI	169
Splicing regulation through biomolecular condensates and membraneless organelles	163
FOXO transcription factors as mediators of stress adaptation	161
Transposons: catch them if you can	152
New tool for MAPping microtubule dynamics	146
RNA binding — a useful third wheel in transcription	146
Activation of human endogenous retroviruses and its physiological consequences	145
Mechanisms and regulation of the Hsp70 chaperone network	143
Mechanisms of mitochondrial respiratory adaptation	141
Context-specific regulation and function of mRNA alternative polyadenylation	137
Does species-specific alternative splicing make us human?	135
Energy-driven genome regulation by ATP-dependent chromatin remodellers	135
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	135

How ancient RNA survives and what we can learn from it	134
Apical–basal polarity and the control of epithelial form and function	126
Targeted protein degradation: from mechanisms to clinic	126
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	124
Transcriptional control of energy metabolism by nuclear receptors	120
Revisiting small RNA movement in plants	118
Molecular machineries and pathways of mitochondrial protein transport	114
Regulation and function of insulin and insulin-like growth factor receptor signalling	112
A guide to cell death pathways	112
Myosin VI assists in fork protection	110
Cold-induced longevity through proteasome boosting	109
New frontiers in quality control: the case of GPI-anchored proteins	104
The centromere as a tag of self-DNA	103
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	103
Redox-driven cell death by disulfidptosis and its therapeutic potential	102
Decoding ubiquitin signals inside cells	101
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	100
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	99
The technological landscape and applications of single-cell multi-omics	97
The molecular basis for cellular function of intrinsically disordered protein regions	97
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	96
Fat cells have long-lasting (epigenetic) memory	95
DEI conversations: more than a box-ticking exercise	95
ATP and ROS signal cell extrusion	95
Genome characteristics at the borders	94
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	92
Deep learning shapes single-cell data analysis	90
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	87
Anticancer effects of zotatifin are mediated by RNA structure remodelling	85
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	78
Microenvironmental determinants of endothelial cell heterogeneity	77
Mechanisms of microtubule organization in differentiated animal cells	76
Interplay between mechanics and signalling in regulating cell fate	74
The role and regulation of integrins in cell migration and invasion	69
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	69
Sleep tight thanks to Parp1	66
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	62
Ethylene — the lifeguard hormone	62
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	60
Unravelling oocyte ultrastructure	60
From shortening telomeres to replicative crisis	59
Transcription factors crossing the cell membrane	55
Profiling the disordered proteome in cells using a chemical tag	54
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	52
Mechanisms and regulation of substrate degradation by the 26S proteasome	52
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	51
Exercise metabolism and adaptation in skeletal muscle	50
The hunter becomes the hunted in target-directed microRNA degradation	50
Karyopherin-mediated nucleocytoplasmic transport	50
The contribution of databases towards understanding the universe of long non-coding RNAs	48
How green is your science? The race to make laboratories sustainable	46
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	46
Cellular role of TETs in early embryos	45
The many regulators of epithelial−mesenchymal transition	45
Translation feedback control in the brain	45
Following the electric current	44
Stem cell sources of colon cancer in mice	42
Cis-regulatory elements that tune transcriptional responses in liver drug metabolism and outcomes	42
Cellular and molecular control of vertebrate somitogenesis	39
Author Correction: The role of the haematopoietic stem cell niche in development and ageing	39
The senescence-associated secretory phenotype and its physiological and pathological implications	36
The birth of evo-devo	34
Calcium connects lysosomal damage to stress granule formation	33
SWI/SNF chromatin remodellers persist through mitosis	32
Mechanisms and regulation of DNA end resection in the maintenance of genome stability	31
Collective cell migration modes in development, tissue repair and cancer	31
Tissue injury leads to the accumulation of somatic mtDNA mutations	31
Deciphering ADP-ribosylation signalling	30
The bystander effect of pyroptosis	29
The bioethics of synthetic cells	29
Mediat(or)ing adult stem cells by XIST	28
Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking	27
Present and future of synthetic cell development	25
Voices of the new generation: my unconventional way to stay in academia	25
ncRNA regulation of mitochondrial transcription	25
ERMES — from myths to molecules	24
Spatiotemporal control over cell–matrix interactions using dynamic micropatterns	23
The emergence of MARUbe — a hybrid ADP-ribose–ubiquitin modification	23
Proteins that assemble co-translationally lean on their partner for stability	23
Harnessing fluorescent probes to unveil dynamic membrane mechanics	23

Functions and therapeutic applications of pseudouridylation	22
Local and systemic mechanisms that control the hair follicle stem cell niche	22
Signalling mechanisms and cellular functions of SUMO	22
Mechanical state transitions in the regulation of tissue form and function	20
Sorting membrane proteins by size in the Golgi	19
Smelling your way to longevity	18
Blebbisomes are one bleb away from a functional cell	17
Lasker Award for AlphaFold	17
Epigenetic discovery by enzyme activity profiling	17
Internal-m7G-modified mRNAs quake under stress	17
Let’s talk about (biological) sex	14
Decoding the interactions and functions of non-coding RNA with artificial intelligence	14
Size matters	13
A nuclear morphology-based machine learning algorithm for senescence detection	13
The nuance in DNA and transcription factor interactions	13
The birth of stable introns	12
Translating the midbody for cytokinesis	12
Early insights into co-translational assembly of protein complexes	11
Mapping organelle supply chains	11
Cellular functions of eukaryotic RNA helicases and their links to human diseases	11
Enabling RNA-compatible synthetic receptors through RNA editing	11
5mC: what goes on must come off	11
Mitochondrial ROS drive cell cycle progression	11
BCL-2 proteins in senescence: beyond a simple target for senolysis?	10
New imprinting control-like regions	10
The discovery of cyclin-dependent kinases	10
Pioneer factors as master regulators of the epigenome and cell fate	9
Genome control by SMC complexes	9
Viruses show the way	9
Mechanisms and regulation of human mitochondrial transcription	9
Mechanistic insights into gasdermin-mediated pyroptosis	9
Single-cell lipidomics reveals the organizing principle of cell fate decision	8
Towards a unified framework for the function of endoplasmic reticulum exit sites	8
Paleoproteomics sheds light on million-year-old fossils	8
Monitoring subcellular protein localization at scale in live cells	8
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing	8
Effects of aneuploidy on cell behaviour and function	7
Gene regulation in time and space during X-chromosome inactivation	7
Author Correction: Fundamentals of redox regulation in biology	7
Exploring the uncharted landscape of truncated mRNAs	7
Shaping epithelial tissues by stem cell mechanics in development and cancer	7
Cell–extracellular matrix mechanotransduction in 3D	7
The double-edged sword of bivalency	6
Returning to the lab after a career break	6
A novel photosystem assembly line worker	6
oskar stands on solid ground for translation	6
Uncovering mRNA sequences that control translation initiation	6
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation	5
Author Correction: Molecular machineries and pathways of mitochondrial protein transport	5
Mechanics and functional consequences of nuclear deformations	5
Condensates trail the nucleus	5
Key challenges and recommendations for defining organelle membrane contact sites	5
Modes of Notch signalling in development and disease	5
Modelling human brain development and disease with organoids	5
Probing cytoskeletal remodelling by cutting and marking filaments	5
Protrusion-derived vesicles: new subtype of EVs?	5
The role of the haematopoietic stem cell niche in development and ageing	5
The lipotype hypothesis	5
Principles and dynamics of spindle assembly checkpoint signalling	5
How embryos sort themselves out	5
Turning the replisome around	4
Challenges and opportunities in macromolecular structure determination	4
The prompt to discover senolytics	4
A histone code controls positional identity in limb regeneration	4
A catalytic function for mammalian Argonautes	4
The memory of viscosity	4
DNA modifications walk a fine line between epigenetics and mutagenesis	4
Molecular machineries shaping the mitochondrial inner membrane	4
Uncovering the complexity of RNA–protein interactions	3
Mechanisms of mechanotransduction and physiological roles of PIEZO channels	3
RNF26 and vimentin orchestrate ER stress recovery	3
Genome doubling — twice the same is not the same	3
Plant microRNA maturation and function	3
The discovery of simple repeats that cause complex disorders	3
Regulation and functions of non-m6A mRNA modifications	3
Senescent cells support limb regeneration	3
The neuronal epigenome is special	3
SLAM passes the haematopoietic stem cell identity test	3
Base editing of organellar DNA with programmable deaminases	3
Regulation of and challenges in targeting NAD+ metabolism	3
MYC in TOP shape	3
Modelling tauopathies	3
Rapid evolution to preserve a conserved function	2
The diffraction limit of light taken by storm	2
oskar switches motors halfway through its journey	2
Mechanisms of auxin action in plant growth and development	2
Heterochromatin as a balancing act between transcription and gene silencing	2
Hypoxia prevents premature ageing in mice	2
Dodging mitochondrial mislocalization	2
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics	2
A guide to membraneless organelles and their various roles in gene regulation	2
Condensates burst the bridge for transcription	2
RPA dynamics at telomeres	2
Learning about break-induced replication from bacteriophages	2
Control of stem cell renewal and fate by YAP and TAZ	2