Nature Reviews Molecular Cell Biology

Article	Citations
The translation m(o)TOR that propels regeneration	2290
When senescence generates pluripotent stem cells	1211
Tightening the epithelium to control signalling	1209
Transfection reflections: fit-for-purpose delivery of nucleic acids	1188
A dynamic culture system that models the intricacy of the mammary gland	1013
From trans-splicing discovery and onwards, trypanosomes lead the way	957
Re-sizing of nuclear pores	755
Mechanisms of substrate processing during ER-associated protein degradation	744
Histone H1 deamidation regulates DNA double-strand break repair	695
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	575
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	574
Understanding mechanisms of antioxidant action in health and disease	528
Modulation of cellular processes by histone and non-histone protein acetylation	499
The aetiology and molecular landscape of insulin resistance	493
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	469
Decoding the Ca2+ signal for salt tolerance	404
Resilience through selective translation	377
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	376
Damaged mitochondria are discarded via migrasomes	373
N-glycan-dependent protein maturation and quality control in the ER	364
Mechanism and regulation of kinesin motors	349
Publisher Correction: Plant hormone regulation of abiotic stress responses	345
Spindle positioning and its impact on vertebrate tissue architecture and cell fate	340
How proteins sense their cellular environment	337
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	329

The emerging mechanisms and functions of microautophagy	327
Endocytosis in the context-dependent regulation of individual and collective cell properties	310
New insights into activation and function of the AMPK	302
The healing role of gasdermin B in IBD	301
C-degron mimicry confers E3 ligase selectivity	296
Bookmarking pluripotency genes	290
Silencing centromeres with age	287
Voices of the new generation: open science is good for science (and for you)	286
The discovery of oncogene-induced senescence	284
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	277
Telomere function and regulation from mouse models to human ageing and disease	274
Regulation of membrane protein structure and function by their lipid nano-environment	273
CRISPR–Cas applications in agriculture and plant research	273
Mechanisms and roles of podosomes and invadopodia	264
Regulation, functions and transmission of bivalent chromatin during mammalian development	262
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design	260
Studying lysosomal function and dysfunction using LysoIP	257
Biology and therapeutic targeting of vascular endothelial growth factor A	253
Curvature-mediated endocytosis	246
The RNA world ‘hypothesis’	236
Big cells, small potential	234
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	226
Molecular tools for analysing in vivo senescence	219
A quick guide to (transmembrane) planar cell polarity mouse strains	213
Science Twitter — navigating change in science communication	204
Migrasomes promote angiogenesis	200
Improving chemical reprogramming strategies	196
The prospects and opportunities of protein structure prediction with AI	195
Splicing regulation through biomolecular condensates and membraneless organelles	194
Context-dependent TGFβ family signalling in cell fate regulation	190
Why novel mRNA modifications are so challenging and what we can do about it	190
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	189
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	184
Machinery, regulation and pathophysiological implications of autophagosome maturation	182
Circadian clock communication during homeostasis and ageing	175
Molecular mechanisms and consequences of mitochondrial permeability transition	173
FOXO transcription factors as mediators of stress adaptation	168
Transposons: catch them if you can	165
RNA binding — a useful third wheel in transcription	160
New tool for MAPping microtubule dynamics	159
Activation of human endogenous retroviruses and its physiological consequences	156
Mechanisms of mitochondrial respiratory adaptation	155
Energy-driven genome regulation by ATP-dependent chromatin remodellers	154
Context-specific regulation and function of mRNA alternative polyadenylation	150
Does species-specific alternative splicing make us human?	149
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	141
Regulation and function of insulin and insulin-like growth factor receptor signalling	140
Revisiting small RNA movement in plants	138
Targeted protein degradation: from mechanisms to clinic	131
A guide to cell death pathways	128

Transcriptional control of energy metabolism by nuclear receptors	127
How ancient RNA survives and what we can learn from it	124
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	122
Myosin VI assists in fork protection	122
Apical–basal polarity and the control of epithelial form and function	122
New frontiers in quality control: the case of GPI-anchored proteins	121
Cold-induced longevity through proteasome boosting	121
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	120
The centromere as a tag of self-DNA	120
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	114
Molecular mechanisms underlying nucleotide repeat expansion disorders	112
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	112
The molecular basis for cellular function of intrinsically disordered protein regions	108
The technological landscape and applications of single-cell multi-omics	106
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	103
DEI conversations: more than a box-ticking exercise	103
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	102
Fat cells have long-lasting (epigenetic) memory	94
Genome characteristics at the borders	93
ATP and ROS signal cell extrusion	90
Anticancer effects of zotatifin are mediated by RNA structure remodelling	89
Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition	88
Microenvironmental determinants of endothelial cell heterogeneity	87
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	86
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	85
Nuclear compartmentalization as a mechanism of quantitative control of gene expression	82
Mechanisms of microtubule organization in differentiated animal cells	82
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	81
The role and regulation of integrins in cell migration and invasion	79
Interplay between mechanics and signalling in regulating cell fate	79
Deep learning shapes single-cell data analysis	78
Sleep tight thanks to Parp1	76
Ethylene — the lifeguard hormone	75
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	74
Unravelling oocyte ultrastructure	72
From shortening telomeres to replicative crisis	70
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	70
The contribution of databases towards understanding the universe of long non-coding RNAs	70
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	68
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	67
Transcription factors crossing the cell membrane	67
Profiling the disordered proteome in cells using a chemical tag	62
How green is your science? The race to make laboratories sustainable	60
The many regulators of epithelial−mesenchymal transition	59
Mechanisms and regulation of substrate degradation by the 26S proteasome	59
The molecular principles of gene regulation by Polycomb repressive complexes	58
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	57
Exercise metabolism and adaptation in skeletal muscle	57
Karyopherin-mediated nucleocytoplasmic transport	56
Mechanisms of SARS-CoV-2 entry into cells	56
Cellular role of TETs in early embryos	55
EV signalling in the haematopoietic niche	55
Cellular and molecular control of vertebrate somitogenesis	52
Translation feedback control in the brain	50
Author Correction: The role of the haematopoietic stem cell niche in development and ageing	49
Following the electric current	46
The birth of evo-devo	44
The senescence-associated secretory phenotype and its physiological and pathological implications	44
SWI/SNF chromatin remodellers persist through mitosis	43
Deciphering ADP-ribosylation signalling	43
Calcium connects lysosomal damage to stress granule formation	42
Mechanisms and regulation of DNA end resection in the maintenance of genome stability	41
The bioethics of synthetic cells	37
The bystander effect of pyroptosis	36
Mediat(or)ing adult stem cells by XIST	33
Keeping oocytes young	33
Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking	33
Voices of the new generation: my unconventional way to stay in academia	32
Harnessing fluorescent probes to unveil dynamic membrane mechanics	30
ERMES — from myths to molecules	29
ncRNA regulation of mitochondrial transcription	28
Proteins that assemble co-translationally lean on their partner for stability	28
Functions and therapeutic applications of pseudouridylation	28
Present and future of synthetic cell development	27
Spatiotemporal control over cell–matrix interactions using dynamic micropatterns	27
Mechanical state transitions in the regulation of tissue form and function	26
Local and systemic mechanisms that control the hair follicle stem cell niche	26
Signalling mechanisms and cellular functions of SUMO	26
Internal-m7G-modified mRNAs quake under stress	25
Smelling your way to longevity	23

Author Correction: Molecular mechanisms underlying nucleotide repeat expansion disorders	23
Epigenetic discovery by enzyme activity profiling	21
Sorting membrane proteins by size in the Golgi	21
A nuclear morphology-based machine learning algorithm for senescence detection	20
Lasker Award for AlphaFold	20
Cracking genetic codes of longevity	20
Blebbisomes are one bleb away from a functional cell	20
The nuance in DNA and transcription factor interactions	20
Let’s talk about (biological) sex	20
Early insights into co-translational assembly of protein complexes	19
Size matters	19
The birth of stable introns	18
Translating the midbody for cytokinesis	17
Enabling RNA-compatible synthetic receptors through RNA editing	15
Mitochondrial ROS drive cell cycle progression	15
Cellular functions of eukaryotic RNA helicases and their links to human diseases	15
Cellular functions of the protein kinase ATM and their relevance to human disease	14
Translational control of stem cell function	13
The discovery of cyclin-dependent kinases	12
New imprinting control-like regions	12
m6A nuclear condensates support AML	12
Control of satellite cell function in muscle regeneration and its disruption in ageing	12
Mapping organelle supply chains	11
Mechanisms and regulation of human mitochondrial transcription	10
Pioneer factors as master regulators of the epigenome and cell fate	10
Viruses show the way	10
5mC: what goes on must come off	10
Single-cell lipidomics reveals the organizing principle of cell fate decision	10
BCL-2 proteins in senescence: beyond a simple target for senolysis?	10
Mechanistic insights into gasdermin-mediated pyroptosis	10
Genome control by SMC complexes	10
Paleoproteomics sheds light on million-year-old fossils	9
Monitoring subcellular protein localization at scale in live cells	9
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing	9
The role of ordered cooperative assembly in biomolecular condensates	9
Effects of aneuploidy on cell behaviour and function	8
Author Correction: Fundamentals of redox regulation in biology	8
Gene regulation in time and space during X-chromosome inactivation	8
Shaping epithelial tissues by stem cell mechanics in development and cancer	8
Exploring the uncharted landscape of truncated mRNAs	7
Returning to the lab after a career break	7
Cell–extracellular matrix mechanotransduction in 3D	7
The double-edged sword of bivalency	7
oskar stands on solid ground for translation	7
A novel photosystem assembly line worker	7
The lipotype hypothesis	6
Principles and dynamics of spindle assembly checkpoint signalling	6
Modes of Notch signalling in development and disease	6
Uncovering mRNA sequences that control translation initiation	6
The role of the haematopoietic stem cell niche in development and ageing	6
Modelling human brain development and disease with organoids	5
Mechanics and functional consequences of nuclear deformations	5
Compression as a driver of hair loss	5
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation	5
Condensates trail the nucleus	5
Protrusion-derived vesicles: new subtype of EVs?	5
BERing transcriptional noise for cell plasticity	5
A catalytic function for mammalian Argonautes	5
Probing cytoskeletal remodelling by cutting and marking filaments	4
How embryos sort themselves out	4
Challenges and opportunities in macromolecular structure determination	4
A histone code controls positional identity in limb regeneration	4
Base editing of organellar DNA with programmable deaminases	4
The prompt to discover senolytics	4
The memory of viscosity	4
DNA modifications walk a fine line between epigenetics and mutagenesis	4
Regulation of microtubule dynamics, mechanics and function through the growing tip	4
Molecular machineries shaping the mitochondrial inner membrane	3
Regulation and functions of non-m6A mRNA modifications	3
Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer	3
The neuronal epigenome is special	3
Regulation of and challenges in targeting NAD+ metabolism	3
Senescent cells support limb regeneration	3
Genome doubling — twice the same is not the same	3
A guide to machine learning for biologists	3
Mechanisms of mechanotransduction and physiological roles of PIEZO channels	3
Modelling tauopathies	3
MYC in TOP shape	3
Cell quiescence sends argonaute-2 to transposons	2
RNF26 and vimentin orchestrate ER stress recovery	2
Control of stem cell renewal and fate by YAP and TAZ	2
Fat accumulation in middle-aged male animals	2
Cytosol-to-nucleus journey of a novel histone PTM	2
A code within the genetic code	2
The multiple links between actin and mitochondria	2
A SOX9 switch from regeneration to fibrosis	2
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics	2
RNA polymerase II transcription compartments: from multivalent chromatin binding to liquid droplet formation?	2
The diffraction limit of light taken by storm	2
Mechanisms of auxin action in plant growth and development	2
Biochemical and mechanical regulation of actin dynamics	2
Slow cell death helps tissue repair	2
First demonstration of miRNA-dependent mRNA decay	2
A guide to membraneless organelles and their various roles in gene regulation	2
Neurons whisper, tissues respond: neurons as orchestrators of stress responses	2