Nature Reviews Molecular Cell Biology

Article	Citations
When senescence generates pluripotent stem cells	2472
The translation m(o)TOR that propels regeneration	1497
Re-sizing of nuclear pores	1444
Transfection reflections: fit-for-purpose delivery of nucleic acids	1197
From trans-splicing discovery and onwards, trypanosomes lead the way	899
A dynamic culture system that models the intricacy of the mammary gland	895
DNA-repair-driven cell death compels us to rethink cancer therapies	860
Tightening the epithelium to control signalling	687
Histone H1 deamidation regulates DNA double-strand break repair	657
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	634
Mechanisms of substrate processing during ER-associated protein degradation	633
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	627
Understanding mechanisms of antioxidant action in health and disease	611
Modulation of cellular processes by histone and non-histone protein acetylation	574
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	471
Decoding the Ca2+ signal for salt tolerance	466
The double life of a transcription factor in the cytoplasm	461
Chemical reprogramming of human blood cells	415
Publisher Correction: Plant hormone regulation of abiotic stress responses	402
Resilience through selective translation	386
How proteins sense their cellular environment	377
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	377
New insights into activation and function of the AMPK	376
N-glycan-dependent protein maturation and quality control in the ER	372
Mechanism and regulation of kinesin motors	371

The advent of confocal laser scanning microscopy in biological research	351
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	350
The emerging mechanisms and functions of microautophagy	342
C-degron mimicry confers E3 ligase selectivity	331
The healing role of gasdermin B in IBD	331
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	330
Nucleosomes as blueprints of genome architecture	322
Studying lysosomal function and dysfunction using LysoIP	321
Bookmarking pluripotency genes	318
Silencing centromeres with age	304
The discovery of oncogene-induced senescence	303
Coordination of cardiogenesis in vivo and in vitro	290
Telomere function and regulation from mouse models to human ageing and disease	289
Mechanisms and roles of podosomes and invadopodia	274
Regulation, functions and transmission of bivalent chromatin during mammalian development	272
Biology and therapeutic targeting of vascular endothelial growth factor A	271
CRISPR–Cas applications in agriculture and plant research	259
Regulation of membrane protein structure and function by their lipid nano-environment	249
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design	235
Curvature-mediated endocytosis	234
Big cells, small potential	230
Molecular tools for analysing in vivo senescence	221
A quick guide to (transmembrane) planar cell polarity mouse strains	221
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	214
Improving chemical reprogramming strategies	199
Migrasomes promote angiogenesis	198
Science Twitter — navigating change in science communication	195
Snoozing APC/C for a sweet cell cycle entry	193
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	191
The RNA world ‘hypothesis’	190
A histone variant that manages abiotic stress in plants	189
Circadian clock communication during homeostasis and ageing	188
Splicing regulation through biomolecular condensates and membraneless organelles	185
The prospects and opportunities of protein structure prediction with AI	180
Why novel mRNA modifications are so challenging and what we can do about it	177
Context-dependent TGFβ family signalling in cell fate regulation	169
FOXO transcription factors as mediators of stress adaptation	167
Molecular mechanisms and consequences of mitochondrial permeability transition	163
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	163
Transposons: catch them if you can	161
New tool for MAPping microtubule dynamics	159
RNA binding — a useful third wheel in transcription	158
Energy-driven genome regulation by ATP-dependent chromatin remodellers	154
Context-specific regulation and function of mRNA alternative polyadenylation	144
Activation of human endogenous retroviruses and its physiological consequences	141
Mechanisms of mitochondrial respiratory adaptation	140
Does species-specific alternative splicing make us human?	135
Transcriptional control of energy metabolism by nuclear receptors	131
How ancient RNA survives and what we can learn from it	131
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	131

Regulation and function of insulin and insulin-like growth factor receptor signalling	131
Revisiting small RNA movement in plants	129
Molecular machineries and pathways of mitochondrial protein transport	128
Apical–basal polarity and the control of epithelial form and function	127
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	121
A guide to cell death pathways	119
Targeted protein degradation: from mechanisms to clinic	113
Myosin VI assists in fork protection	110
New frontiers in quality control: the case of GPI-anchored proteins	110
Cold-induced longevity through proteasome boosting	110
The centromere as a tag of self-DNA	106
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	105
Redox-driven cell death by disulfidptosis and its therapeutic potential	100
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	99
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	99
The molecular basis for cellular function of intrinsically disordered protein regions	98
The technological landscape and applications of single-cell multi-omics	96
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	95
ATP and ROS signal cell extrusion	95
DEI conversations: more than a box-ticking exercise	95
Fat cells have long-lasting (epigenetic) memory	95
Genome characteristics at the borders	94
Mechanisms of microtubule organization in differentiated animal cells	93
Deep learning shapes single-cell data analysis	92
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	92
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	89
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	89
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	88
Microenvironmental determinants of endothelial cell heterogeneity	85
Anticancer effects of zotatifin are mediated by RNA structure remodelling	83
The role and regulation of integrins in cell migration and invasion	83
Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition	81
Interplay between mechanics and signalling in regulating cell fate	80
Sleep tight thanks to Parp1	76
Ethylene — the lifeguard hormone	74
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	71
Unravelling oocyte ultrastructure	66
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	64
From shortening telomeres to replicative crisis	62
Transcription factors crossing the cell membrane	61
The contribution of databases towards understanding the universe of long non-coding RNAs	61
Profiling the disordered proteome in cells using a chemical tag	59
How green is your science? The race to make laboratories sustainable	57
The hunter becomes the hunted in target-directed microRNA degradation	55
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	53
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	53
Exercise metabolism and adaptation in skeletal muscle	52
Karyopherin-mediated nucleocytoplasmic transport	50
The many regulators of epithelial−mesenchymal transition	46
Mechanisms and regulation of substrate degradation by the 26S proteasome	46
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	44
Mechanisms of SARS-CoV-2 entry into cells	44
Cellular role of TETs in early embryos	42
Author Correction: The role of the haematopoietic stem cell niche in development and ageing	42
Translation feedback control in the brain	42
Following the electric current	41
Cellular and molecular control of vertebrate somitogenesis	41
Stem cell sources of colon cancer in mice	39
The senescence-associated secretory phenotype and its physiological and pathological implications	38
The birth of evo-devo	38
SWI/SNF chromatin remodellers persist through mitosis	37
Calcium connects lysosomal damage to stress granule formation	37
Deciphering ADP-ribosylation signalling	37
Tissue injury leads to the accumulation of somatic mtDNA mutations	36
The bioethics of synthetic cells	35
The bystander effect of pyroptosis	31
Collective cell migration modes in development, tissue repair and cancer	30
Mechanisms and regulation of DNA end resection in the maintenance of genome stability	30
Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking	29
Mediat(or)ing adult stem cells by XIST	29
Present and future of synthetic cell development	27
Local and systemic mechanisms that control the hair follicle stem cell niche	27
The emergence of MARUbe — a hybrid ADP-ribose–ubiquitin modification	26
Mechanical state transitions in the regulation of tissue form and function	24
Voices of the new generation: my unconventional way to stay in academia	23
ncRNA regulation of mitochondrial transcription	23
ERMES — from myths to molecules	22
Spatiotemporal control over cell–matrix interactions using dynamic micropatterns	21
Proteins that assemble co-translationally lean on their partner for stability	21
Functions and therapeutic applications of pseudouridylation	20

Signalling mechanisms and cellular functions of SUMO	20
Harnessing fluorescent probes to unveil dynamic membrane mechanics	20
Sorting membrane proteins by size in the Golgi	19
Lasker Award for AlphaFold	18
Smelling your way to longevity	18
Internal-m7G-modified mRNAs quake under stress	18
Epigenetic discovery by enzyme activity profiling	17
A nuclear morphology-based machine learning algorithm for senescence detection	16
Decoding the interactions and functions of non-coding RNA with artificial intelligence	16
Let’s talk about (biological) sex	16
Blebbisomes are one bleb away from a functional cell	16
The nuance in DNA and transcription factor interactions	14
Size matters	13
Cellular functions of eukaryotic RNA helicases and their links to human diseases	12
Early insights into co-translational assembly of protein complexes	12
The birth of stable introns	12
Control of satellite cell function in muscle regeneration and its disruption in ageing	12
Translating the midbody for cytokinesis	12
Enabling RNA-compatible synthetic receptors through RNA editing	12
Mapping organelle supply chains	11
Mitochondrial ROS drive cell cycle progression	11
5mC: what goes on must come off	11
The discovery of cyclin-dependent kinases	11
Mechanisms and regulation of human mitochondrial transcription	10
New imprinting control-like regions	10
BCL-2 proteins in senescence: beyond a simple target for senolysis?	9
Mechanistic insights into gasdermin-mediated pyroptosis	9
Pioneer factors as master regulators of the epigenome and cell fate	9
Viruses show the way	9
Genome control by SMC complexes	9
Gene regulation in time and space during X-chromosome inactivation	8
Author Correction: Fundamentals of redox regulation in biology	8
Shaping epithelial tissues by stem cell mechanics in development and cancer	8
Paleoproteomics sheds light on million-year-old fossils	8
Single-cell lipidomics reveals the organizing principle of cell fate decision	8
Towards a unified framework for the function of endoplasmic reticulum exit sites	8
Monitoring subcellular protein localization at scale in live cells	8
A novel photosystem assembly line worker	7
Cell–extracellular matrix mechanotransduction in 3D	7
oskar stands on solid ground for translation	7
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing	7
The double-edged sword of bivalency	7
Exploring the uncharted landscape of truncated mRNAs	7
Effects of aneuploidy on cell behaviour and function	7
Principles and dynamics of spindle assembly checkpoint signalling	6
Protrusion-derived vesicles: new subtype of EVs?	6
Uncovering mRNA sequences that control translation initiation	6
Author Correction: Molecular machineries and pathways of mitochondrial protein transport	6
Returning to the lab after a career break	6
Modes of Notch signalling in development and disease	6
Regulation and functions of non-m6A mRNA modifications	5
Modelling human brain development and disease with organoids	5
The lipotype hypothesis	5
Compression as a driver of hair loss	5
The role of the haematopoietic stem cell niche in development and ageing	5
Mechanics and functional consequences of nuclear deformations	5
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation	5
Key challenges and recommendations for defining organelle membrane contact sites	5
Condensates trail the nucleus	4
Challenges and opportunities in macromolecular structure determination	4
Probing cytoskeletal remodelling by cutting and marking filaments	4
Mechanisms of mechanotransduction and physiological roles of PIEZO channels	4
A histone code controls positional identity in limb regeneration	4
How embryos sort themselves out	4
Turning the replisome around	4
Molecular machineries shaping the mitochondrial inner membrane	4
DNA modifications walk a fine line between epigenetics and mutagenesis	3
A catalytic function for mammalian Argonautes	3
Senescent cells support limb regeneration	3
Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer	3
Uncovering the complexity of RNA–protein interactions	3
Good neighbours transfer nucleotides	3
The prompt to discover senolytics	3
Regulation of and challenges in targeting NAD+ metabolism	3
MYC in TOP shape	3
Genome doubling — twice the same is not the same	3
Modelling tauopathies	3
Plant microRNA maturation and function	3
The memory of viscosity	3
Base editing of organellar DNA with programmable deaminases	3
RNF26 and vimentin orchestrate ER stress recovery	3
The discovery of simple repeats that cause complex disorders	3
The neuronal epigenome is special	3
Cell quiescence sends argonaute-2 to transposons	3
Distal enhancers loop to proximal enhancers, not to promoters	3
Hypoxia prevents premature ageing in mice	2
Dodging mitochondrial mislocalization	2
oskar switches motors halfway through its journey	2
Condensates burst the bridge for transcription	2
RPA dynamics at telomeres	2
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics	2
Control of stem cell renewal and fate by YAP and TAZ	2
Rapid evolution to preserve a conserved function	2
Learning about break-induced replication from bacteriophages	2
A guide to membraneless organelles and their various roles in gene regulation	2