OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 32. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)

Article	Citations
The biological and clinical significance of emerging SARS-CoV-2 variants	649
Engineering adeno-associated virus vectors for gene therapy	499
Abiotic stress responses in plants	458
Deciphering cell–cell interactions and communication from gene expression	420
mRNAs, proteins and the emerging principles of gene expression control	415
Long-read human genome sequencing and its applications	411
Determinants of enhancer and promoter activities of regulatory elements	384
Regulation of gene expression by cis-acting long non-coding RNAs	383
Context is everything: aneuploidy in cancer	321
Methods for mapping 3D chromosome architecture	316
Cell-free gene expression: an expanded repertoire of applications	313
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics	310
Lineage tracing meets single-cell omics: opportunities and challenges	292
Structural variation in the sequencing era	275
RNA-binding proteins in human genetic disease	269
The epitranscriptome beyond m6A	269
The genetics of obesity: from discovery to biology	266
Harnessing genomics to fast-track genetic improvement in aquaculture	222
Drug delivery systems for RNA therapeutics	216
Testing at scale during the COVID-19 pandemic	213
The evolving metabolic landscape of chromatin biology and epigenetics	200
Human organs-on-chips for disease modelling, drug development and personalized medicine	198
Mechanisms of early placental development in mouse and humans	195
Towards a comprehensive catalogue of validated and target-linked human enhancers	186
Transposable elements in human genetic disease	182

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics	181
Polygenic adaptation: a unifying framework to understand positive selection	175
A decade of advances in transposon-insertion sequencing	172
Phylogenetic tree building in the genomic age	171
Building machines with DNA molecules	166
Measuring and interpreting transposable element expression	163
The genetics of human ageing	160
Pan-genomics in the human genome era	152
Genetics meets proteomics: perspectives for large population-based studies	144
Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire	134
The epigenetic basis of cellular heterogeneity	130
Histone post-translational modifications — cause and consequence of genome function	126
Rare-variant collapsing analyses for complex traits: guidelines and applications	126
Towards population-scale long-read sequencing	121
Molecular mechanisms of transgenerational epigenetic inheritance	120
Overcoming challenges and dogmas to understand the functions of pseudogenes	119
The relationship between genome structure and function	118
Reprogramming the genetic code	118
Chromosome organization in bacteria: mechanistic insights into genome structure and function	115
Emerging mechanisms of cell competition	113
Molecular and evolutionary processes generating variation in gene expression	112
Rights, interests and expectations: Indigenous perspectives on unrestricted access to genomic data	110
Gene therapy using haematopoietic stem and progenitor cells	108
Extreme heterogeneity of human mitochondrial DNA from organelles to populations	107
Next-generation computational tools for interrogating cancer immunity	104
COMPASS and SWI/SNF complexes in development and disease	104
Enhancer redundancy in development and disease	103
The influence of evolutionary history on human health and disease	101
The road ahead in genetics and genomics	99
Haematopoietic stem cell self-renewal in vivo and ex vivo	96
Transposable elements shape the evolution of mammalian development	96
Animal domestication in the era of ancient genomics	95
Active turnover of DNA methylation during cell fate decisions	92
Host–parasite co-evolution and its genomic signature	86
Mining genomes to illuminate the specialized chemistry of life	84
Mechanisms of tissue and cell-type specificity in heritable traits and diseases	83
Gene regulatory programmes of tissue regeneration	83
The emerging landscape of spatial profiling technologies	83
Host genetics and infectious disease: new tools, insights and translational opportunities	79
Redefining fundamental concepts of transcription initiation in bacteria	79
Advancing the use of genome-wide association studies for drug repurposing	69
A new era in functional genomics screens	67
Electronic health records and polygenic risk scores for predicting disease risk	66
The genomics of coloration provides insights into adaptive evolution	66
A framework for an evidence-based gene list relevant to autism spectrum disorder	66
Exploring human genomic diversity with gnomAD	65
Navigating the pitfalls of applying machine learning in genomics	64
A systems approach to infectious disease	64
From molecules to populations: appreciating and estimating recombination rate variation	64
The importance of genomic variation for biodiversity, ecosystems and people	62

The roles of microRNAs in mouse development	61
Clinical cancer genomic profiling	59
The Human Genome Project changed everything	59
Gene drives gaining speed	57
Measuring biological age using omics data	56
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination	54
Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic	53
Genetic engineering of T cells for immunotherapy	52
Responsible, practical genomic data sharing that accelerates research	52
Genetic load: genomic estimates and applications in non-model animals	52
Conserved chromosomal functions of RNA interference	52
African genetic diversity and adaptation inform a precision medicine agenda	52
Making sense of the ageing methylome	51
Epigenome plasticity in plants	51
Parental nucleosome segregation and the inheritance of cellular identity	50
Methods and applications for single-cell and spatial multi-omics	48
Statistical mechanics meets single-cell biology	47
Alternative splicing as a source of phenotypic diversity	46
Prime editing for precise and highly versatile genome manipulation	46
Single-cell atlases: shared and tissue-specific cell types across human organs	46
Genetics of substance use disorders in the era of big data	45
Generation of extracellular morphogen gradients: the case for diffusion	44
Obtaining genetics insights from deep learning via explainable artificial intelligence	44
Maternal H3K27me3-dependent autosomal and X chromosome imprinting	43
Advances and opportunities in malaria population genomics	43
Testing the super-enhancer concept	43
Interplay between chromatin marks in development and disease	43
The potential of mitochondrial genome engineering	42
Mechanical regulation of chromatin and transcription	42
Polygenic scores in biomedical research	42
Beyond broad strokes: sociocultural insights from the study of ancient genomes	41
Opportunities and challenges of macrogenetic studies	39
Germline risk of clonal haematopoiesis	38
DNA methylation-based predictors of health: applications and statistical considerations	38
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	37
Overlapping genes in natural and engineered genomes	37
Discovering and validating cancer genetic dependencies: approaches and pitfalls	37
Theranostic cells: emerging clinical applications of synthetic biology	37
Cross-species RNA-seq for deciphering host–microbe interactions	37
Temporal modelling using single-cell transcriptomics	37
Characterizing cis-regulatory elements using single-cell epigenomics	36
Genetic innovations in animal–microbe symbioses	36
The human genetic epidemiology of COVID-19	35
Decoding disease: from genomes to networks to phenotypes	32