OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 29. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
The different faces of transcription factor sensitivity	1290
High-resolution 3D genome characterization	896
Explaining the male bias in cancers	803
Single-cell expression profiling has its roots in in situ techniques	774
Tightening the (neural) net for protein structure prediction	721
Disentangling population structure in marine species	640
Enhancing sustainable development through plant genetics	604
The evolution of DNA sequencing with microfluidics	599
SCOPE-ing out eukaryotic 6mA	514
Weaponized genomics: potential threats to international and human security	387
The evolution of modifier genes	349
Genomic prediction of neoantigens: immunogenomics before NGS	348
Getting organized with non-coding RNAs	332
Mining genomes to illuminate the specialized chemistry of life	313
Interrogating epigenetic mechanisms with chemically customized chromatin	304
Imprinted genes and the manipulation of parenting in mammals	284
Means, mechanisms and consequences of adenine methylation in DNA	270
Pleiotropy, epistasis and the genetic architecture of quantitative traits	254
Harnessing deep learning for population genetic inference	236
Genomic insights into conifer evolution	208
Unveiling the expanding protein universe of life	199
Rapid pathogen surveillance: field-ready sequencing solutions	196
Progress in toxicogenomics to protect human health	193
More than a decade of genetic research on the Denisovans	191
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	183

Testing at scale during the COVID-19 pandemic	181
Changes in cell-cycle rate drive diverging cell fates	177
The origin of animals and fungi	176
Testing the super-enhancer concept	168
Best practices for single-cell analysis across modalities	167
Abiotic stress responses in plants	163
CRISPR editing within microbial communities	158
Shared genetic components of multimorbidity	149
Layering epigenomic and transcriptomic space	143
Intrinsically disordered regions as facilitators of the transcription factor target search	139
Revealing gene function with statistical inference at single-cell resolution	138
Genomic landscape of cancer in racially and ethnically diverse populations	134
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	134
Mapping dosage	131
Aneuploidy in the driving seat	128
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	128
Mini-colons unlock tumour development outside the body	125
Genetics of substance use disorders in the era of big data	124
Single cell–cell communication	118
Targeted genome-modification tools and their advanced applications in crop breeding	118
Predicting the effects of multigene perturbations	117
Epigenomes get personal	116
CHIPping away at the genetic aetiology of clonal haematopoiesis	113
The hidden diversity of tumours	113
Miller spreads and the power of observation	110
Swapping genes within and beyond our bodies	109
Retrotransposons: still mobile in humans	108
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	102
Mate choice through a genomic lens	101
Cohesin and CTCF emerge as building blocks of 3D genome structure	101
Fine-mapping causal variants — why finding ‘the one’ can be futile	101
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	99
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	97
The origin and evolution of Wnt signalling	97
Genomic newborn screening for rare diseases	95
Social shifts in spiders	95
The final pieces of the human genome	89
Why geneticists should care about male infertility	86
Fitness effects of mutations throughout evolution	84
Global genomic diversity for All of Us	84
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	82
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	82
Targeting and engineering long non-coding RNAs for cancer therapy	79
The potential of mitochondrial genome engineering	75
High-throughput biochemistry in RNA sequence space: predicting structure and function	73
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	72
The diversification of methods for studying cell–cell interactions and communication	72
Exon junction complex modulates m6A distribution	72
Effects of regulatory variants across pig tissues	72
A digital marker for coronary artery disease	69

A whole-genome shotgun approach to human reference genome sequencing	66
Mosaic variegated aneuploidy in development, ageing and cancer	65
Sex-specific morphs: the genetics and evolution of intra-sexual variation	65
Divergence and conservation of the meiotic recombination machinery	64
Navigating the pitfalls of mapping DNA and RNA modifications	64
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	64
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	61
Chromosomal instability as a driver of cancer progression	60
The expanding diagnostic toolbox for rare genetic diseases	60
Genomics for monitoring and understanding species responses to global climate change	60
Genetics of circadian rhythms and sleep in human health and disease	59
Genomic surveillance for antimicrobial resistance — a One Health perspective	58
Laterally mobile chromosomes	57
Programmable DNA rearrangements using bridge RNAs	56
Using cell-free DNA to infer gene expression	56
How ancient genes form animal body plans	55
SCENT defines non-coding disease mechanisms using single-cell multi-omics	54
The evolutionary tale of lactase persistence in humans	53
Prioritizing the detection of rare pathogenic variants in population screening	53
microRNAs as systemic regulators of ageing	52
A developmental exit from totipotency	49
Widespread occurrence of circular RNA in eukaryotes	49
New insights into genome folding by loop extrusion from inducible degron technologies	46
Translating genomic advances into biodiversity conservation	44
Challenges and best practices in omics benchmarking	44
Context-specific functions of chromatin remodellers in development and disease	43
Theranostic cells: emerging clinical applications of synthetic biology	42
Biobanking with genetics shapes precision medicine and global health	41
Author Correction: Transposable elements: McClintock’s legacy revisited	38
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	36
The lives of cells, recorded	36
Global cooperation for a global pandemic	35
Publisher Correction: Germline risk of clonal haematopoiesis	35
Context-specific regulatory variants in precision medicine and agriculture	35
The FinnGen study: disease insights from a ‘bottlenecked’ population	34
Multifunctional histone variants in genome function	34
Integrating ELSI study teams in paediatric genomic research efforts	34
Packaging and delivery of genome-editing tools	33
The nexus between RNA-binding proteins and their effectors	31
tRNA dysregulation and disease	31
Methods and applications for single-cell and spatial multi-omics	31
In vivo editing of blood stem cells	30
The continuum of transcription factor affinities	29
Homozygosity mapping: a game-changer for autosomal recessive diseases	29
De novo genes: from non-genic to genic	29