OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Regulatory promoter architectures in the hands of thermodynamic modelling	1074
Grand designs of the nucleus	854
High-resolution 3D genome characterization	666
Quantifying the effect of reference genome choice	622
A mammoth contribution to ancient genomics	615
Cell interaction by multiplet sequencing	566
Diversity and consequences of structural variation in the human genome	456
SCOPE-ing out eukaryotic 6mA	411
GETting at single-cell chromatin dynamics	370
Genomic prediction of neoantigens: immunogenomics before NGS	283
Prioritizing the detection of rare pathogenic variants in population screening	283
Sequencing to save the Kākāpō	242
Illuminating the human yolk sac through single-cell omics	241
Sex and age affect circadian gene expression	229
Dissecting the genetics of ovarian ageing	222
Maverick — top gun of horizontal gene transfer	208
Including diverse populations enhances the discovery of type 2 diabetes loci	203
Efficient computation reveals rare CRISPR–Cas systems	195
Fighting fibrosis with transient CAR T cells	183
Laterally mobile chromosomes	165
Towards gene therapy for Tay-Sachs disease	164
CRISPR systems go mini	157
The different faces of transcription factor sensitivity	154
microRNAs as systemic regulators of ageing	150
Promoting a new view of mitochondrial genome regulation	143

Reverting to old theories of ageing with new evidence for the role of somatic mutations	140
Chromatin loops stack up	138
The evolutionary tale of lactase persistence in humans	134
New insights into genome folding by loop extrusion from inducible degron technologies	134
Tightening the (neural) net for protein structure prediction	132
Using cell-free DNA to infer gene expression	126
Neighbourly modulation of transcript isoforms	119
Disentangling population structure in marine species	116
Getting organized with non-coding RNAs	114
Assigning phenotypes to essential human genes	109
The GLUE that holds omics layers together	102
DNA packaging by molecular motors: from bacteriophage to human chromosomes	99
Giant genomes of lungfish	98
Enhancing sustainable development through plant genetics	97
Base editing takes a shot at disease in non-human primates	97
Human cell-lineage imbalances	96
Explaining the male bias in cancers	96
Selection on synonymous sites: the unwanted transcript hypothesis	95
The puzzling guppy Y chromosome	94
SCENT defines non-coding disease mechanisms using single-cell multi-omics	94
The complex non-genetic inheritance of complex traits	92
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination	91
Imprinted genes and the manipulation of parenting in mammals	91
Human organs-on-chips for disease modelling, drug development and personalized medicine	90
A developmental exit from totipotency	87
The evolution of modifier genes	84
Interpreting non-coding disease-associated human variants using single-cell epigenomics	84
How ancient genes form animal body plans	82
The TOPMed genomic resource for human health	81
Pleiotropy, epistasis and the genetic architecture of quantitative traits	80
Computational methods for analysing multiscale 3D genome organization	79
Weaponized genomics: potential threats to international and human security	79
Programmable DNA rearrangements using bridge RNAs	79
Tandem repeat variation of human centromeres	77
Single-cell expression profiling has its roots in in situ techniques	75
Genetics of glycosylation in mammalian development and disease	75
Translating genomic advances into biodiversity conservation	74
Genetic conflict and its resolution between the sexes	74
Context-specific functions of chromatin remodellers in development and disease	73
Autophagy genes in biology and disease	72
Measuring biological age using omics data	71
DNA methylation in mammalian development and disease	71
Pioneer factors — key regulators of chromatin and gene expression	68
Widespread occurrence of circular RNA in eukaryotes	66
Repetitive DNA: genomic dark matter matters	64
Deafness: from genetic architecture to gene therapy	64
Microbiome epidemiology and association studies in human health	61
DNA methylation-based predictors of health: applications and statistical considerations	60
Harnessing deep learning for population genetic inference	60
Mining genomes to illuminate the specialized chemistry of life	60

Means, mechanisms and consequences of adenine methylation in DNA	60
Making sense of the ageing methylome	60
Interrogating epigenetic mechanisms with chemically customized chromatin	58
Challenges and best practices in omics benchmarking	58
Biobanking with genetics shapes precision medicine and global health	57
Transposable elements: McClintock’s legacy revisited	56
The evolution of DNA sequencing with microfluidics	55
A deep learning method to map tissue architecture	49
The therapeutic potential of circular RNAs	49
Theranostic cells: emerging clinical applications of synthetic biology	49
Opportunities and challenges of macrogenetic studies	49
WNT regulator controls stripe patterning	47
Gregor Mendel and the concepts of dominance and recessiveness	47
Spatial resolution of host–microbiome interactions	46
The origin of animals and fungi	45
Detecting ribosomal footprints in single cells	45
Global cooperation for a global pandemic	45
A comprehensive view of human RNAs	43
Profiling human-specific VNTR expansions	42
Enhancing initiation	42
The magic and meaning of Mendel’s miracle	41
The Neanderthal inside us	40
From LD-based mapping to GWAS	37
Abiotic stress responses in plants	36
Computational analysis of cancer genome sequencing data	36
Beyond assembly: the increasing flexibility of single-molecule sequencing technology	33
Overlapping genes in natural and engineered genomes	29
Disentangling host–microbiota complexity through hologenomics	28
Generating specificity in genome regulation through transcription factor sensitivity to chromatin	27
Spatial mapping of translation in single cells	27
A panoramic view of mouse organogenesis	27
Target-directed microRNA degradation in Drosophila	26
Unveiling the expanding protein universe of life	25
Mapping vertebrate brain evolution	25
Genetic prediction of multi-omic traits	25
Spatial epigenomics in single cells	24
Genomic insights into conifer evolution	24
Pan-cancer atlas of intratumour heterogeneity	24
Gene regulatory network inference in the era of single-cell multi-omics	23
Chromatin loops facilitate co-regulation of paralogues	23
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	22
Epigenome plasticity in plants	22
Temporal modelling using single-cell transcriptomics	21
Predicting variant pathogenicity with AlphaMissense	20
Multifunctional histone variants in genome function	20
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	19
Context-specific regulatory variants in precision medicine and agriculture	19
Genome-scale models in human metabologenomics	19