OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Single-cell expression profiling has its roots in in situ techniques	1008
Explaining the male bias in cancers	922
The different faces of transcription factor sensitivity	742
The evolution of modifier genes	701
Disentangling population structure in marine species	545
The evolution of DNA sequencing with microfluidics	511
Weaponized genomics: potential threats to international and human security	488
Imprinted genes and the manipulation of parenting in mammals	413
Microorganisms as architects of a sustainable future	386
Gene regulatory networks: from correlative models to causal explanations	379
Harnessing deep learning for population genetic inference	366
Interrogating epigenetic mechanisms with chemically customized chromatin	318
Pleiotropy, epistasis and the genetic architecture of quantitative traits	302
Enhancing sustainable development through plant genetics	284
Unveiling the expanding protein universe of life	280
Rapid pathogen surveillance: field-ready sequencing solutions	278
The origin of animals and fungi	246
The evolutionary foundations of transcriptional regulation in animals	240
Cis-regulatory elements at cellular resolution	230
More than a decade of genetic research on the Denisovans	223
Changes in cell-cycle rate drive diverging cell fates	219
Long non-coding RNAs as orchestrators of dosage compensation	213
RNA polymerase II transcription compartments — from factories to condensates	209
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	206
Progress in toxicogenomics to protect human health	204

Best practices for single-cell analysis across modalities	196
Mapping dosage	192
Mini-colons unlock tumour development outside the body	188
Non-retroviral RNA viruses in eukaryotic genomes	186
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	179
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores	179
Annotating genomes at increased scale and resolution	174
Revealing gene function with statistical inference at single-cell resolution	168
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	166
Targeted genome-modification tools and their advanced applications in crop breeding	163
Intrinsically disordered regions as facilitators of the transcription factor target search	158
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	146
Layering epigenomic and transcriptomic space	145
Genomic landscape of cancer in racially and ethnically diverse populations	137
Epigenomes get personal	135
Predicting the effects of multigene perturbations	131
The hidden diversity of tumours	130
Swapping genes within and beyond our bodies	121
Mate choice through a genomic lens	120
Miller spreads and the power of observation	116
Cohesin and CTCF emerge as building blocks of 3D genome structure	113
Single cell–cell communication	109
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	109
CHIPping away at the genetic aetiology of clonal haematopoiesis	106
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	105
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	104
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	104
Redefining cellular reprogramming with advanced genomic technologies	99
Genomic newborn screening for rare diseases	96
Clinical use of polygenic risk scores: current status, barriers and future directions	93
Global genomic diversity for All of Us	92
The origin and evolution of Wnt signalling	92
Social shifts in spiders	90
Fitness effects of mutations throughout evolution	90
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	89
Targeting and engineering long non-coding RNAs for cancer therapy	88
High-throughput biochemistry in RNA sequence space: predicting structure and function	84
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	82
Why geneticists should care about male infertility	78
Recoding genomes with programmed ribosomal frameshifting	77
The diversification of methods for studying cell–cell interactions and communication	76
Effects of regulatory variants across pig tissues	75
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	75
A digital marker for coronary artery disease	73
A whole-genome shotgun approach to human reference genome sequencing	69
Microbial genomics for antimicrobial resistance ecology and action	69
Exon junction complex modulates m6A distribution	66
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	64
Mosaic variegated aneuploidy in development, ageing and cancer	63
Genomic surveillance for antimicrobial resistance — a One Health perspective	61

Navigating the pitfalls of mapping DNA and RNA modifications	61
Sex-specific morphs: the genetics and evolution of intra-sexual variation	60
Chromosomal instability as a driver of cancer progression	59
The expanding diagnostic toolbox for rare genetic diseases	59
Genomics for monitoring and understanding species responses to global climate change	56
Divergence and conservation of the meiotic recombination machinery	55
TimeVault: a synthetic time capsule for transcriptome storage	54
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	54
Programmable DNA rearrangements using bridge RNAs	53
Genetics of circadian rhythms and sleep in human health and disease	53
A developmental exit from totipotency	52
SCENT defines non-coding disease mechanisms using single-cell multi-omics	52
Harnessing evolution to infer protein networks	49
microRNAs as systemic regulators of ageing	49
How ancient genes form animal body plans	48
The evolutionary tale of lactase persistence in humans	46
Prioritizing the detection of rare pathogenic variants in population screening	46
Functional synonymous mutations and their evolutionary consequences	46
Challenges and best practices in omics benchmarking	44
Context-specific functions of chromatin remodellers in development and disease	43
Tools and tactics for studying alternative splicing	42
Translating genomic advances into biodiversity conservation	40
Biobanking with genetics shapes precision medicine and global health	39
Integrating ELSI study teams in paediatric genomic research efforts	39
New insights into genome folding by loop extrusion from inducible degron technologies	39
Global cooperation for a global pandemic	39
Reading cell division histories from the methylome	38
tRNA dysregulation and disease	38
Towards improved fine-mapping of candidate causal variants	37
The lives of cells, recorded	37
Packaging and delivery of genome-editing tools	36
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	35
Nascent transcription quantification with scFLUENT-seq	34
Author Correction: Transposable elements: McClintock’s legacy revisited	34
Cell-type deconvolution methods for spatial transcriptomics	32
Context-specific regulatory variants in precision medicine and agriculture	32
The nexus between RNA-binding proteins and their effectors	32
Multifunctional histone variants in genome function	32
The FinnGen study: disease insights from a ‘bottlenecked’ population	32
Predicting gene expression from DNA sequence using deep learning models	31
Methods and applications for single-cell and spatial multi-omics	30
In vivo editing of blood stem cells	29
Mary Lyon and the birth of X-inactivation research	28