OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Single-cell expression profiling has its roots in in situ techniques	1151
Explaining the male bias in cancers	1024
The different faces of transcription factor sensitivity	834
The evolution of modifier genes	786
Disentangling population structure in marine species	597
Weaponized genomics: potential threats to international and human security	568
Imprinted genes and the manipulation of parenting in mammals	446
Interrogating epigenetic mechanisms with chemically customized chromatin	423
Microorganisms as architects of a sustainable future	355
Harnessing deep learning for population genetic inference	330
How evolution builds three morphs from one genome	322
Folding a broken genome: the versatile roles of cohesin in genome maintenance	321
Enhancing sustainable development through plant genetics	304
Pleiotropy, epistasis and the genetic architecture of quantitative traits	301
The evolution of DNA sequencing with microfluidics	257
Gene regulatory networks: from correlative models to causal explanations	250
Unveiling the expanding protein universe of life	240
The origin of animals and fungi	223
The unbearable presence of senescent cells in ageing	222
Cis-regulatory elements at cellular resolution	221
Changes in cell-cycle rate drive diverging cell fates	220
Molecular integration of seasonal temperature signals in flowering time control	218
The evolutionary foundations of transcriptional regulation in animals	216
Rapid pathogen surveillance: field-ready sequencing solutions	211
Long non-coding RNAs as orchestrators of dosage compensation	206

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	201
RNA polymerase II transcription compartments — from factories to condensates	196
More than a decade of genetic research on the Denisovans	195
Progress in toxicogenomics to protect human health	194
Best practices for single-cell analysis across modalities	179
Mapping dosage	157
Intrinsically disordered regions as facilitators of the transcription factor target search	151
Adaptation: by giant leaps or many tiny steps?	148
Mini-colons unlock tumour development outside the body	146
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	129
Non-retroviral RNA viruses in eukaryotic genomes	123
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	122
Genomic landscape of cancer in racially and ethnically diverse populations	119
Advancing the applications of liquid biopsies in oncology	119
Layering epigenomic and transcriptomic space	118
Annotating genomes at increased scale and resolution	114
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores	110
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	110
Revealing gene function with statistical inference at single-cell resolution	109
Targeted genome-modification tools and their advanced applications in crop breeding	108
Predicting the effects of multigene perturbations	107
The hidden diversity of tumours	103
Swapping genes within and beyond our bodies	102
Mate choice through a genomic lens	101
Single cell–cell communication	100
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	99
CHIPping away at the genetic aetiology of clonal haematopoiesis	97
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	96
Miller spreads and the power of observation	94
Cohesin and CTCF emerge as building blocks of 3D genome structure	93
Redefining cellular reprogramming with advanced genomic technologies	92
Epigenomes get personal	90
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	90
The origin and evolution of Wnt signalling	84
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	82
Clinical use of polygenic risk scores: current status, barriers and future directions	79
Genomic newborn screening for rare diseases	75
Global genomic diversity for All of Us	75
Social shifts in spiders	73
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	73
Fitness effects of mutations throughout evolution	73
Recoding genomes with programmed ribosomal frameshifting	70
Why geneticists should care about male infertility	68
Prime editing: redefining precision genome editing	68
High-throughput biochemistry in RNA sequence space: predicting structure and function	67
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	65
The diversification of methods for studying cell–cell interactions and communication	65
Effects of regulatory variants across pig tissues	64
Targeting and engineering long non-coding RNAs for cancer therapy	64
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	64

A digital marker for coronary artery disease	63
A whole-genome shotgun approach to human reference genome sequencing	62
Microbial genomics for antimicrobial resistance ecology and action	62
Exon junction complex modulates m6A distribution	61
Mosaic variegated aneuploidy in development, ageing and cancer	59
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	58
Navigating the pitfalls of mapping DNA and RNA modifications	56
TimeVault: a synthetic time capsule for transcriptome storage	56
The expanding diagnostic toolbox for rare genetic diseases	55
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	55
Sex-specific morphs: the genetics and evolution of intra-sexual variation	54
Divergence and conservation of the meiotic recombination machinery	52
Genomic surveillance for antimicrobial resistance — a One Health perspective	50
Genetics of circadian rhythms and sleep in human health and disease	50
Chromosomal instability as a driver of cancer progression	50
Genomics for monitoring and understanding species responses to global climate change	49
Bidirectional functional genomics using CRISPR-KOALA	47
Programmable DNA rearrangements using bridge RNAs	46
A developmental exit from totipotency	44
SCENT defines non-coding disease mechanisms using single-cell multi-omics	44
How ancient genes form animal body plans	43
Prioritizing the detection of rare pathogenic variants in population screening	42
Revisiting retinal and macular degeneration in the genomics era	42
Harnessing evolution to infer protein networks	42
The evolutionary tale of lactase persistence in humans	42
microRNAs as systemic regulators of ageing	42
New insights into genome folding by loop extrusion from inducible degron technologies	41
Context-specific functions of chromatin remodellers in development and disease	41
Tools and tactics for studying alternative splicing	39
Biobanking with genetics shapes precision medicine and global health	39
Functional synonymous mutations and their evolutionary consequences	39
Challenges and best practices in omics benchmarking	38
Translating genomic advances into biodiversity conservation	37
Packaging and delivery of genome-editing tools	36
Integrating ELSI study teams in paediatric genomic research efforts	36
Reading cell division histories from the methylome	35
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	35
Author Correction: Transposable elements: McClintock’s legacy revisited	34
Nascent transcription quantification with scFLUENT-seq	34
Context-specific regulatory variants in precision medicine and agriculture	33
The FinnGen study: disease insights from a ‘bottlenecked’ population	32
Predicting gene expression from DNA sequence using deep learning models	30
Multifunctional histone variants in genome function	30
Single-cell four-omics with CHARM	30