OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Tightening the (neural) net for protein structure prediction	965
Enhancing sustainable development through plant genetics	950
Single-cell expression profiling has its roots in in situ techniques	778
Explaining the male bias in cancers	749
The different faces of transcription factor sensitivity	671
SCOPE-ing out eukaryotic 6mA	541
The evolution of modifier genes	495
Harnessing deep learning for population genetic inference	437
Weaponized genomics: potential threats to international and human security	413
Interrogating epigenetic mechanisms with chemically customized chromatin	401
Getting organized with non-coding RNAs	373
Disentangling population structure in marine species	325
Imprinted genes and the manipulation of parenting in mammals	308
The evolution of DNA sequencing with microfluidics	263
Means, mechanisms and consequences of adenine methylation in DNA	255
Pleiotropy, epistasis and the genetic architecture of quantitative traits	246
Genomic insights into conifer evolution	234
Unveiling the expanding protein universe of life	210
Rapid pathogen surveillance: field-ready sequencing solutions	209
The origin of animals and fungi	203
Changes in cell-cycle rate drive diverging cell fates	197
Cis-regulatory elements at cellular resolution	197
The evolutionary foundations of transcriptional regulation in animals	191
RNA polymerase II transcription compartments — from factories to condensates	191
Best practices for single-cell analysis across modalities	180

Progress in toxicogenomics to protect human health	173
More than a decade of genetic research on the Denisovans	173
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	169
Non-retroviral RNA viruses in eukaryotic genomes	168
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores	162
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	160
Mapping dosage	160
Layering epigenomic and transcriptomic space	154
Mini-colons unlock tumour development outside the body	152
Genomic landscape of cancer in racially and ethnically diverse populations	151
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	151
CRISPR editing within microbial communities	137
Revealing gene function with statistical inference at single-cell resolution	135
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	132
Intrinsically disordered regions as facilitators of the transcription factor target search	132
Targeted genome-modification tools and their advanced applications in crop breeding	130
Epigenomes get personal	127
Predicting the effects of multigene perturbations	126
CHIPping away at the genetic aetiology of clonal haematopoiesis	121
The hidden diversity of tumours	118
Swapping genes within and beyond our bodies	114
Mate choice through a genomic lens	112
Miller spreads and the power of observation	111
Single cell–cell communication	110
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	108
Cohesin and CTCF emerge as building blocks of 3D genome structure	107
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	103
Fine-mapping causal variants — why finding ‘the one’ can be futile	102
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	99
Retrotransposons: still mobile in humans	97
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	96
Genomic newborn screening for rare diseases	95
The origin and evolution of Wnt signalling	93
Global genomic diversity for All of Us	91
Social shifts in spiders	89
The final pieces of the human genome	88
Fitness effects of mutations throughout evolution	86
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	84
The potential of mitochondrial genome engineering	84
High-throughput biochemistry in RNA sequence space: predicting structure and function	82
Targeting and engineering long non-coding RNAs for cancer therapy	82
Why geneticists should care about male infertility	81
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	79
The diversification of methods for studying cell–cell interactions and communication	77
Effects of regulatory variants across pig tissues	74
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	73
Exon junction complex modulates m6A distribution	71
A digital marker for coronary artery disease	68
Divergence and conservation of the meiotic recombination machinery	67
A whole-genome shotgun approach to human reference genome sequencing	67

Mosaic variegated aneuploidy in development, ageing and cancer	67
Sex-specific morphs: the genetics and evolution of intra-sexual variation	64
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	63
Navigating the pitfalls of mapping DNA and RNA modifications	62
Genetics of circadian rhythms and sleep in human health and disease	61
The expanding diagnostic toolbox for rare genetic diseases	60
Chromosomal instability as a driver of cancer progression	59
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	58
Genomics for monitoring and understanding species responses to global climate change	56
Genomic surveillance for antimicrobial resistance — a One Health perspective	54
Programmable DNA rearrangements using bridge RNAs	52
Using cell-free DNA to infer gene expression	50
SCENT defines non-coding disease mechanisms using single-cell multi-omics	49
Laterally mobile chromosomes	49
A developmental exit from totipotency	48
The evolutionary tale of lactase persistence in humans	48
microRNAs as systemic regulators of ageing	47
Prioritizing the detection of rare pathogenic variants in population screening	47
How ancient genes form animal body plans	46
New insights into genome folding by loop extrusion from inducible degron technologies	44
Functional synonymous mutations and their evolutionary consequences	41
Biobanking with genetics shapes precision medicine and global health	40
Challenges and best practices in omics benchmarking	39
Context-specific functions of chromatin remodellers in development and disease	39
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	38
Translating genomic advances into biodiversity conservation	38
Context-specific regulatory variants in precision medicine and agriculture	37
Author Correction: Transposable elements: McClintock’s legacy revisited	37
Global cooperation for a global pandemic	34
tRNA dysregulation and disease	33
Cell-type deconvolution methods for spatial transcriptomics	33
The FinnGen study: disease insights from a ‘bottlenecked’ population	33
Integrating ELSI study teams in paediatric genomic research efforts	32
Packaging and delivery of genome-editing tools	31
Towards improved fine-mapping of candidate causal variants	30
The nexus between RNA-binding proteins and their effectors	30
The lives of cells, recorded	30
Multifunctional histone variants in genome function	29
Predicting gene expression from DNA sequence using deep learning models	29
In vivo editing of blood stem cells	28
Methods and applications for single-cell and spatial multi-omics	28
Homozygosity mapping: a game-changer for autosomal recessive diseases	25
Publisher Correction: Sociotechnical safeguards for genomic data privacy	24
Mary Lyon and the birth of X-inactivation research	23
Corrupted USB1 fails to process microRNAs required for blood development	23
Stem cell-derived organoid models: defying the Hayflick limit	22
Ancient migration and the modern genome	22
The regulatory landscape of chromatin accessibility	22