OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 29. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
Abiotic stress responses in plants	846
The biological and clinical significance of emerging SARS-CoV-2 variants	798
mRNAs, proteins and the emerging principles of gene expression control	646
Deciphering cell–cell interactions and communication from gene expression	637
Drug delivery systems for RNA therapeutics	509
The genetics of obesity: from discovery to biology	490
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics	473
Human organs-on-chips for disease modelling, drug development and personalized medicine	461
RNA-binding proteins in human genetic disease	382
The epitranscriptome beyond m6A	381
Histone post-translational modifications — cause and consequence of genome function	330
The evolving metabolic landscape of chromatin biology and epigenetics	270
Methods and applications for single-cell and spatial multi-omics	270
Testing at scale during the COVID-19 pandemic	270
Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics	237
Genetics meets proteomics: perspectives for large population-based studies	220
Best practices for single-cell analysis across modalities	216
Molecular mechanisms of transgenerational epigenetic inheritance	214
Towards population-scale long-read sequencing	179
The relationship between genome structure and function	177
The emerging landscape of spatial profiling technologies	175
The epigenetic basis of cellular heterogeneity	173
Prime editing for precise and highly versatile genome manipulation	172
Molecular and evolutionary processes generating variation in gene expression	163
Gene therapy using haematopoietic stem and progenitor cells	162

Reprogramming the genetic code	155
Alternative splicing as a source of phenotypic diversity	153
COMPASS and SWI/SNF complexes in development and disease	152
Transposable elements shape the evolution of mammalian development	151
Measuring biological age using omics data	150
Emerging mechanisms of cell competition	150
Autophagy genes in biology and disease	150
Enhancer redundancy in development and disease	150
The influence of evolutionary history on human health and disease	140
Extreme heterogeneity of human mitochondrial DNA from organelles to populations	135
Mining genomes to illuminate the specialized chemistry of life	129
The road ahead in genetics and genomics	126
A new era in functional genomics screens	123
Advancing the use of genome-wide association studies for drug repurposing	122
Navigating the pitfalls of applying machine learning in genomics	120
Active turnover of DNA methylation during cell fate decisions	120
Obtaining genetics insights from deep learning via explainable artificial intelligence	116
Host–parasite co-evolution and its genomic signature	113
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination	111
Host genetics and infectious disease: new tools, insights and translational opportunities	108
Gene drives gaining speed	104
Redefining fundamental concepts of transcription initiation in bacteria	104
Biological roles of adenine methylation in RNA	103
microRNAs in action: biogenesis, function and regulation	100
Making sense of the ageing methylome	99
Genetic load: genomic estimates and applications in non-model animals	97
DNA methylation-based predictors of health: applications and statistical considerations	90
Clinical cancer genomic profiling	87
The Human Genome Project changed everything	85
Characterizing cis-regulatory elements using single-cell epigenomics	83
Primary cilia as dynamic and diverse signalling hubs in development and disease	83
Epigenome plasticity in plants	83
Single-cell atlases: shared and tissue-specific cell types across human organs	81
Temporal modelling using single-cell transcriptomics	79
The roles of microRNAs in mouse development	79
Generation of extracellular morphogen gradients: the case for diffusion	79
Polygenic scores in biomedical research	79
African genetic diversity and adaptation inform a precision medicine agenda	78
The importance of genomic variation for biodiversity, ecosystems and people	78
Advances and opportunities in malaria population genomics	77
Responsible, practical genomic data sharing that accelerates research	76
Mechanical regulation of chromatin and transcription	75
Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic	75
The human genetic epidemiology of COVID-19	75
Genetic innovations in animal–microbe symbioses	73
tRNA dysregulation and disease	72
Genetic engineering of T cells for immunotherapy	72
Parental nucleosome segregation and the inheritance of cellular identity	72
Interplay between chromatin marks in development and disease	72
Gene regulatory network inference in the era of single-cell multi-omics	71

Pharmacogenomics: current status and future perspectives	67
Genetics of substance use disorders in the era of big data	67
The potential of mitochondrial genome engineering	66
Genetics of circadian rhythms and sleep in human health and disease	66
Statistical mechanics meets single-cell biology	65
Organization and expression of the mammalian mitochondrial genome	64
Probing the dynamic RNA structurome and its functions	63
Overlapping genes in natural and engineered genomes	63
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects	60
Genetics of human telomere biology disorders	58
Testing the super-enhancer concept	58
The spatial organization of transcriptional control	58
Cross-species RNA-seq for deciphering host–microbe interactions	57
Dynamic alternative DNA structures in biology and disease	57
Opportunities and challenges of macrogenetic studies	57
Generating specificity in genome regulation through transcription factor sensitivity to chromatin	56
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	55
Theranostic cells: emerging clinical applications of synthetic biology	54
Spatial biology of cancer evolution	54
Means, mechanisms and consequences of adenine methylation in DNA	54
Sociotechnical safeguards for genomic data privacy	52
Molecular mechanisms of environmental exposures and human disease	52
Germline risk of clonal haematopoiesis	51
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	50
Origins of human disease: the chrono-epigenetic perspective	48
Decoding disease: from genomes to networks to phenotypes	47
Non-coding RNAs in disease: from mechanisms to therapeutics	47
Engineering synthetic RNA devices for cell control	47
Context-specific Polycomb mechanisms in development	46
Disentangling host–microbiota complexity through hologenomics	46
Principles and methods for transferring polygenic risk scores across global populations	46
Examining the evidence for extracellular RNA function in mammals	44
Computational analysis of cancer genome sequencing data	44
HIV-1 and human genetic variation	42
Engineering 3D genome organization	40
Towards improved genetic diagnosis of human differences of sex development	39
Extrachromosomal DNA amplifications in cancer	39
Mutation–selection balance and compensatory mechanisms in tumour evolution	39
Genomic newborn screening for rare diseases	37
RNA: a double-edged sword in genome maintenance	37
Single-cell genomics meets human genetics	36
New insights into genome folding by loop extrusion from inducible degron technologies	36
Variant calling and benchmarking in an era of complete human genome sequences	36
Soma-to-germline RNA communication	35
Incongruence in the phylogenomics era	35
The origin of human mutation in light of genomic data	34
Transposable elements in mammalian chromatin organization	33
RNA modifications in physiology and disease: towards clinical applications	30
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	29