OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Tightening the (neural) net for protein structure prediction	1013
Single-cell expression profiling has its roots in in situ techniques	985
Explaining the male bias in cancers	818
The different faces of transcription factor sensitivity	782
SCOPE-ing out eukaryotic 6mA	709
The evolution of modifier genes	583
Disentangling population structure in marine species	534
Microorganisms as architects of a sustainable future	454
Interrogating epigenetic mechanisms with chemically customized chromatin	425
Harnessing deep learning for population genetic inference	420
Enhancing sustainable development through plant genetics	387
Getting organized with non-coding RNAs	341
Imprinted genes and the manipulation of parenting in mammals	317
The evolution of DNA sequencing with microfluidics	287
Weaponized genomics: potential threats to international and human security	277
Pleiotropy, epistasis and the genetic architecture of quantitative traits	252
Means, mechanisms and consequences of adenine methylation in DNA	244
Genomic insights into conifer evolution	217
Unveiling the expanding protein universe of life	215
Rapid pathogen surveillance: field-ready sequencing solutions	214
The origin of animals and fungi	208
Cis-regulatory elements at cellular resolution	207
Changes in cell-cycle rate drive diverging cell fates	203
The evolutionary foundations of transcriptional regulation in animals	199
RNA polymerase II transcription compartments — from factories to condensates	187

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	181
Progress in toxicogenomics to protect human health	180
Best practices for single-cell analysis across modalities	179
More than a decade of genetic research on the Denisovans	178
Non-retroviral RNA viruses in eukaryotic genomes	169
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores	168
Mapping dosage	165
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	160
Mini-colons unlock tumour development outside the body	159
Genomic landscape of cancer in racially and ethnically diverse populations	158
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	156
CRISPR editing within microbial communities	141
Targeted genome-modification tools and their advanced applications in crop breeding	140
Revealing gene function with statistical inference at single-cell resolution	137
Intrinsically disordered regions as facilitators of the transcription factor target search	136
Layering epigenomic and transcriptomic space	136
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	132
Epigenomes get personal	129
Predicting the effects of multigene perturbations	128
The hidden diversity of tumours	124
Swapping genes within and beyond our bodies	120
Mate choice through a genomic lens	116
Miller spreads and the power of observation	115
Cohesin and CTCF emerge as building blocks of 3D genome structure	113
Single cell–cell communication	113
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	112
Redefining cellular reprogramming with advanced genomic technologies	108
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	105
CHIPping away at the genetic aetiology of clonal haematopoiesis	104
Fine-mapping causal variants — why finding ‘the one’ can be futile	99
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	97
Retrotransposons: still mobile in humans	94
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	91
Clinical use of polygenic risk scores: current status, barriers and future directions	91
The origin and evolution of Wnt signalling	89
Global genomic diversity for All of Us	88
Social shifts in spiders	88
Genomic newborn screening for rare diseases	88
Fitness effects of mutations throughout evolution	85
The final pieces of the human genome	85
Targeting and engineering long non-coding RNAs for cancer therapy	84
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	83
The diversification of methods for studying cell–cell interactions and communication	74
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	73
Why geneticists should care about male infertility	72
High-throughput biochemistry in RNA sequence space: predicting structure and function	71
The potential of mitochondrial genome engineering	71
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	70
Effects of regulatory variants across pig tissues	70
Exon junction complex modulates m6A distribution	69

A digital marker for coronary artery disease	68
A whole-genome shotgun approach to human reference genome sequencing	67
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	66
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	65
Genetics of circadian rhythms and sleep in human health and disease	63
Mosaic variegated aneuploidy in development, ageing and cancer	58
Divergence and conservation of the meiotic recombination machinery	58
Sex-specific morphs: the genetics and evolution of intra-sexual variation	55
Genomic surveillance for antimicrobial resistance — a One Health perspective	54
Navigating the pitfalls of mapping DNA and RNA modifications	53
The expanding diagnostic toolbox for rare genetic diseases	53
Genomics for monitoring and understanding species responses to global climate change	52
Chromosomal instability as a driver of cancer progression	51
Laterally mobile chromosomes	49
Using cell-free DNA to infer gene expression	49
Programmable DNA rearrangements using bridge RNAs	49
SCENT defines non-coding disease mechanisms using single-cell multi-omics	46
The evolutionary tale of lactase persistence in humans	46
A developmental exit from totipotency	42
microRNAs as systemic regulators of ageing	42
Prioritizing the detection of rare pathogenic variants in population screening	41
How ancient genes form animal body plans	40
Biobanking with genetics shapes precision medicine and global health	40
New insights into genome folding by loop extrusion from inducible degron technologies	39
Translating genomic advances into biodiversity conservation	39
Challenges and best practices in omics benchmarking	39
Functional synonymous mutations and their evolutionary consequences	37
Context-specific functions of chromatin remodellers in development and disease	35
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	35
Author Correction: Transposable elements: McClintock’s legacy revisited	34
Context-specific regulatory variants in precision medicine and agriculture	33
Global cooperation for a global pandemic	33
The FinnGen study: disease insights from a ‘bottlenecked’ population	32
Towards improved fine-mapping of candidate causal variants	31
Predicting gene expression from DNA sequence using deep learning models	30
The nexus between RNA-binding proteins and their effectors	30
Cell-type deconvolution methods for spatial transcriptomics	29
Multifunctional histone variants in genome function	29
Packaging and delivery of genome-editing tools	29
Integrating ELSI study teams in paediatric genomic research efforts	27
The lives of cells, recorded	27
tRNA dysregulation and disease	26
Methods and applications for single-cell and spatial multi-omics	26
In vivo editing of blood stem cells	25
Homozygosity mapping: a game-changer for autosomal recessive diseases	24
Mary Lyon and the birth of X-inactivation research	23
Publisher Correction: Sociotechnical safeguards for genomic data privacy	23