OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-01-01 to 2025-01-01.)

Article	Citations
Regulatory promoter architectures in the hands of thermodynamic modelling	1074
A new view of genome organization	854
Grand designs of the nucleus	666
Short H2A variants act as oncohistones	622
High-resolution 3D genome characterization	615
Quantifying the effect of reference genome choice	566
A mammoth contribution to ancient genomics	456
Cell interaction by multiplet sequencing	411
SCOPE-ing out eukaryotic 6mA	370
Genomic prediction of neoantigens: immunogenomics before NGS	283
GETting at single-cell chromatin dynamics	283
Prioritizing the detection of rare pathogenic variants in population screening	242
Sequencing to save the Kākāpō	241
Illuminating the human yolk sac through single-cell omics	229
Sex and age affect circadian gene expression	222
Dissecting the genetics of ovarian ageing	208
Maverick — top gun of horizontal gene transfer	203
Including diverse populations enhances the discovery of type 2 diabetes loci	195
Efficient computation reveals rare CRISPR–Cas systems	183
Fighting fibrosis with transient CAR T cells	173
Laterally mobile chromosomes	165
Towards gene therapy for Tay-Sachs disease	164
CRISPR systems go mini	161
The different faces of transcription factor sensitivity	157
microRNAs as systemic regulators of ageing	154

Promoting a new view of mitochondrial genome regulation	150
Reverting to old theories of ageing with new evidence for the role of somatic mutations	143
Chromatin loops stack up	140
New insights into genome folding by loop extrusion from inducible degron technologies	138
The evolutionary tale of lactase persistence in humans	134
Tightening the (neural) net for protein structure prediction	134
Using cell-free DNA to infer gene expression	132
Neighbourly modulation of transcript isoforms	126
Disentangling population structure in marine species	119
Getting organized with non-coding RNAs	116
Assigning phenotypes to essential human genes	114
The GLUE that holds omics layers together	109
DNA packaging by molecular motors: from bacteriophage to human chromosomes	102
Giant genomes of lungfish	99
Enhancing sustainable development through plant genetics	98
Base editing takes a shot at disease in non-human primates	97
Explaining the male bias in cancers	97
Selection on synonymous sites: the unwanted transcript hypothesis	96
Human cell-lineage imbalances	96
SCENT defines non-coding disease mechanisms using single-cell multi-omics	95
The complex non-genetic inheritance of complex traits	94
The puzzling guppy Y chromosome	94
Imprinted genes and the manipulation of parenting in mammals	92
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination	91
Human organs-on-chips for disease modelling, drug development and personalized medicine	91
A developmental exit from totipotency	90
The evolution of modifier genes	88
Interpreting non-coding disease-associated human variants using single-cell epigenomics	87
The TOPMed genomic resource for human health	84
How ancient genes form animal body plans	84
Pleiotropy, epistasis and the genetic architecture of quantitative traits	83
Computational methods for analysing multiscale 3D genome organization	82
Programmable DNA rearrangements using bridge RNAs	81
Weaponized genomics: potential threats to international and human security	81
Tandem repeat variation of human centromeres	80
Translating genomic advances into biodiversity conservation	79
Genetics of glycosylation in mammalian development and disease	79
Single-cell expression profiling has its roots in in situ techniques	79
Genetic conflict and its resolution between the sexes	77
Widespread occurrence of circular RNA in eukaryotes	75
Context-specific functions of chromatin remodellers in development and disease	75
Deafness: from genetic architecture to gene therapy	74
Repetitive DNA: genomic dark matter matters	74
Microbiome epidemiology and association studies in human health	73
Means, mechanisms and consequences of adenine methylation in DNA	72
Making sense of the ageing methylome	71
Harnessing deep learning for population genetic inference	71
Parental nucleosome segregation and the inheritance of cellular identity	68
Mining genomes to illuminate the specialized chemistry of life	66
Challenges and best practices in omics benchmarking	64

DNA methylation-based predictors of health: applications and statistical considerations	64
Interrogating epigenetic mechanisms with chemically customized chromatin	61
A deep learning method to map tissue architecture	60
Enhancer redundancy in development and disease	60
The evolution of DNA sequencing with microfluidics	60
Biobanking with genetics shapes precision medicine and global health	60
Transposable elements: McClintock’s legacy revisited	60
Autophagy genes in biology and disease	58
Theranostic cells: emerging clinical applications of synthetic biology	58
DNA methylation in mammalian development and disease	57
Measuring biological age using omics data	56
Pioneer factors — key regulators of chromatin and gene expression	55
Spatial resolution of host–microbiome interactions	49
WNT regulator controls stripe patterning	49
Opportunities and challenges of macrogenetic studies	49
Gregor Mendel and the concepts of dominance and recessiveness	49
Multifunctional histone variants in genome function	47
The origin of animals and fungi	47
Global cooperation for a global pandemic	46
Enhancing initiation	45
A comprehensive view of human RNAs	45
Detecting ribosomal footprints in single cells	45
Fixing an ageing mutation	43
Profiling human-specific VNTR expansions	42
Cascading CRISPR–Cas9 genome edits	42
The magic and meaning of Mendel’s miracle	41
The Neanderthal inside us	40
From LD-based mapping to GWAS	37
Abiotic stress responses in plants	36
Computational analysis of cancer genome sequencing data	36
Beyond assembly: the increasing flexibility of single-molecule sequencing technology	33
The influence of evolutionary history on human health and disease	29
Overlapping genes in natural and engineered genomes	28
A panoramic view of mouse organogenesis	27
Disentangling host–microbiota complexity through hologenomics	27
Generating specificity in genome regulation through transcription factor sensitivity to chromatin	27
Spatial mapping of translation in single cells	26
Mapping vertebrate brain evolution	25
Genetic prediction of multi-omic traits	25
Target-directed microRNA degradation in Drosophila	25
Spatial epigenomics in single cells	24
Unveiling the expanding protein universe of life	24
Genomic insights into conifer evolution	24
Chromatin loops facilitate co-regulation of paralogues	23
Pan-cancer atlas of intratumour heterogeneity	23
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	22
Gene regulatory network inference in the era of single-cell multi-omics	22