OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 25. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Tightening the (neural) net for protein structure prediction	1050
Single-cell expression profiling has its roots in in situ techniques	1017
Explaining the male bias in cancers	863
The different faces of transcription factor sensitivity	806
SCOPE-ing out eukaryotic 6mA	744
The evolution of modifier genes	614
Enhancing sustainable development through plant genetics	574
Microorganisms as architects of a sustainable future	468
Disentangling population structure in marine species	437
Means, mechanisms and consequences of adenine methylation in DNA	436
Imprinted genes and the manipulation of parenting in mammals	405
Weaponized genomics: potential threats to international and human security	358
Interrogating epigenetic mechanisms with chemically customized chromatin	327
The evolution of DNA sequencing with microfluidics	309
Pleiotropy, epistasis and the genetic architecture of quantitative traits	300
Harnessing deep learning for population genetic inference	261
Genomic insights into conifer evolution	258
Unveiling the expanding protein universe of life	226
Rapid pathogen surveillance: field-ready sequencing solutions	225
The origin of animals and fungi	219
Cis-regulatory elements at cellular resolution	218
Changes in cell-cycle rate drive diverging cell fates	211
The evolutionary foundations of transcriptional regulation in animals	205
RNA polymerase II transcription compartments — from factories to condensates	196
Progress in toxicogenomics to protect human health	186

More than a decade of genetic research on the Denisovans	185
Best practices for single-cell analysis across modalities	184
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	183
Non-retroviral RNA viruses in eukaryotic genomes	182
Mapping dosage	181
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	172
Mini-colons unlock tumour development outside the body	170
Layering epigenomic and transcriptomic space	164
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores	163
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	161
CRISPR editing within microbial communities	147
Revealing gene function with statistical inference at single-cell resolution	146
Genomic landscape of cancer in racially and ethnically diverse populations	144
Targeted genome-modification tools and their advanced applications in crop breeding	142
Intrinsically disordered regions as facilitators of the transcription factor target search	142
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	139
Epigenomes get personal	133
Predicting the effects of multigene perturbations	131
The hidden diversity of tumours	130
Swapping genes within and beyond our bodies	128
Mate choice through a genomic lens	126
Miller spreads and the power of observation	121
Single cell–cell communication	121
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	118
Retrotransposons: still mobile in humans	117
Fine-mapping causal variants — why finding ‘the one’ can be futile	114
CHIPping away at the genetic aetiology of clonal haematopoiesis	113
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	111
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	102
Redefining cellular reprogramming with advanced genomic technologies	102
Clinical use of polygenic risk scores: current status, barriers and future directions	97
The origin and evolution of Wnt signalling	96
Cohesin and CTCF emerge as building blocks of 3D genome structure	94
Genomic newborn screening for rare diseases	93
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	92
Global genomic diversity for All of Us	91
Fitness effects of mutations throughout evolution	91
The final pieces of the human genome	91
Social shifts in spiders	91
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	89
Why geneticists should care about male infertility	84
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	79
The potential of mitochondrial genome engineering	78
The diversification of methods for studying cell–cell interactions and communication	77
Targeting and engineering long non-coding RNAs for cancer therapy	75
High-throughput biochemistry in RNA sequence space: predicting structure and function	75
Effects of regulatory variants across pig tissues	74
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	73
Exon junction complex modulates m6A distribution	73
A digital marker for coronary artery disease	72

A whole-genome shotgun approach to human reference genome sequencing	71
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	69
Microbial genomics for antimicrobial resistance ecology and action	66
Divergence and conservation of the meiotic recombination machinery	61
Navigating the pitfalls of mapping DNA and RNA modifications	61
Sex-specific morphs: the genetics and evolution of intra-sexual variation	59
Mosaic variegated aneuploidy in development, ageing and cancer	59
Genetics of circadian rhythms and sleep in human health and disease	57
Genomics for monitoring and understanding species responses to global climate change	57
Chromosomal instability as a driver of cancer progression	55
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	54
The expanding diagnostic toolbox for rare genetic diseases	53
Genomic surveillance for antimicrobial resistance — a One Health perspective	53
Using cell-free DNA to infer gene expression	50
Programmable DNA rearrangements using bridge RNAs	50
SCENT defines non-coding disease mechanisms using single-cell multi-omics	49
The evolutionary tale of lactase persistence in humans	45
A developmental exit from totipotency	45
microRNAs as systemic regulators of ageing	44
Challenges and best practices in omics benchmarking	43
How ancient genes form animal body plans	43
Context-specific functions of chromatin remodellers in development and disease	42
Harnessing evolution to infer protein networks	42
New insights into genome folding by loop extrusion from inducible degron technologies	41
Prioritizing the detection of rare pathogenic variants in population screening	40
Functional synonymous mutations and their evolutionary consequences	36
Biobanking with genetics shapes precision medicine and global health	35
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	35
Translating genomic advances into biodiversity conservation	35
Author Correction: Transposable elements: McClintock’s legacy revisited	33
Global cooperation for a global pandemic	33
The FinnGen study: disease insights from a ‘bottlenecked’ population	32
Packaging and delivery of genome-editing tools	30
Nascent transcription quantification with scFLUENT-seq	30
Context-specific regulatory variants in precision medicine and agriculture	30
Integrating ELSI study teams in paediatric genomic research efforts	29
Towards improved fine-mapping of candidate causal variants	29
Predicting gene expression from DNA sequence using deep learning models	27
The lives of cells, recorded	27
Cell-type deconvolution methods for spatial transcriptomics	27
tRNA dysregulation and disease	27
Methods and applications for single-cell and spatial multi-omics	26
The nexus between RNA-binding proteins and their effectors	26
Multifunctional histone variants in genome function	25
Publisher Correction: Sociotechnical safeguards for genomic data privacy	25
In vivo editing of blood stem cells	25