OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 37. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
The biological and clinical significance of emerging SARS-CoV-2 variants	756
Abiotic stress responses in plants	718
mRNAs, proteins and the emerging principles of gene expression control	576
Deciphering cell–cell interactions and communication from gene expression	565
Long-read human genome sequencing and its applications	537
Drug delivery systems for RNA therapeutics	426
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics	418
The genetics of obesity: from discovery to biology	414
Human organs-on-chips for disease modelling, drug development and personalized medicine	367
RNA-binding proteins in human genetic disease	354
The epitranscriptome beyond m6A	345
Harnessing genomics to fast-track genetic improvement in aquaculture	270
Histone post-translational modifications — cause and consequence of genome function	259
The evolving metabolic landscape of chromatin biology and epigenetics	254
Testing at scale during the COVID-19 pandemic	249
A decade of advances in transposon-insertion sequencing	227
Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics	225
Phylogenetic tree building in the genomic age	221
Measuring and interpreting transposable element expression	208
Polygenic adaptation: a unifying framework to understand positive selection	207
Methods and applications for single-cell and spatial multi-omics	196
Genetics meets proteomics: perspectives for large population-based studies	188
Molecular mechanisms of transgenerational epigenetic inheritance	181
Towards population-scale long-read sequencing	164
The epigenetic basis of cellular heterogeneity	161

The relationship between genome structure and function	159
The emerging landscape of spatial profiling technologies	150
Molecular and evolutionary processes generating variation in gene expression	148
Gene therapy using haematopoietic stem and progenitor cells	147
Reprogramming the genetic code	147
Best practices for single-cell analysis across modalities	141
COMPASS and SWI/SNF complexes in development and disease	139
Emerging mechanisms of cell competition	138
Prime editing for precise and highly versatile genome manipulation	137
Transposable elements shape the evolution of mammalian development	135
Rights, interests and expectations: Indigenous perspectives on unrestricted access to genomic data	133
The influence of evolutionary history on human health and disease	130
Enhancer redundancy in development and disease	129
Extreme heterogeneity of human mitochondrial DNA from organelles to populations	126
Alternative splicing as a source of phenotypic diversity	125
The road ahead in genetics and genomics	119
Measuring biological age using omics data	117
Haematopoietic stem cell self-renewal in vivo and ex vivo	116
Animal domestication in the era of ancient genomics	115
Active turnover of DNA methylation during cell fate decisions	114
Navigating the pitfalls of applying machine learning in genomics	110
Mining genomes to illuminate the specialized chemistry of life	110
Autophagy genes in biology and disease	108
Host–parasite co-evolution and its genomic signature	108
Advancing the use of genome-wide association studies for drug repurposing	102
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination	101
A new era in functional genomics screens	101
Gene regulatory programmes of tissue regeneration	98
Redefining fundamental concepts of transcription initiation in bacteria	98
Host genetics and infectious disease: new tools, insights and translational opportunities	96
Gene drives gaining speed	91
Obtaining genetics insights from deep learning via explainable artificial intelligence	88
The genomics of coloration provides insights into adaptive evolution	83
Making sense of the ageing methylome	82
A framework for an evidence-based gene list relevant to autism spectrum disorder	82
Exploring human genomic diversity with gnomAD	82
Genetic load: genomic estimates and applications in non-model animals	79
From molecules to populations: appreciating and estimating recombination rate variation	79
The Human Genome Project changed everything	77
Clinical cancer genomic profiling	75
The importance of genomic variation for biodiversity, ecosystems and people	75
Biological roles of adenine methylation in RNA	74
Epigenome plasticity in plants	73
Single-cell atlases: shared and tissue-specific cell types across human organs	73
Characterizing cis-regulatory elements using single-cell epigenomics	71
The roles of microRNAs in mouse development	71
Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic	70
Generation of extracellular morphogen gradients: the case for diffusion	68
African genetic diversity and adaptation inform a precision medicine agenda	67
Responsible, practical genomic data sharing that accelerates research	66

Temporal modelling using single-cell transcriptomics	66
Polygenic scores in biomedical research	66
DNA methylation-based predictors of health: applications and statistical considerations	66
Genetic engineering of T cells for immunotherapy	65
The human genetic epidemiology of COVID-19	64
Interplay between chromatin marks in development and disease	63
Mechanical regulation of chromatin and transcription	61
Parental nucleosome segregation and the inheritance of cellular identity	61
Genetic innovations in animal–microbe symbioses	60
Statistical mechanics meets single-cell biology	60
Genetics of substance use disorders in the era of big data	59
The potential of mitochondrial genome engineering	58
Overlapping genes in natural and engineered genomes	57
Advances and opportunities in malaria population genomics	57
Primary cilia as dynamic and diverse signalling hubs in development and disease	56
microRNAs in action: biogenesis, function and regulation	56
Genetics of circadian rhythms and sleep in human health and disease	53
Cross-species RNA-seq for deciphering host–microbe interactions	53
Genetics of human telomere biology disorders	52
tRNA dysregulation and disease	52
The spatial organization of transcriptional control	52
Testing the super-enhancer concept	52
Maternal H3K27me3-dependent autosomal and X chromosome imprinting	51
Opportunities and challenges of macrogenetic studies	51
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	50
Pharmacogenomics: current status and future perspectives	50
Theranostic cells: emerging clinical applications of synthetic biology	48
Germline risk of clonal haematopoiesis	47
Probing the dynamic RNA structurome and its functions	46
Organization and expression of the mammalian mitochondrial genome	45
Decoding disease: from genomes to networks to phenotypes	45
Generating specificity in genome regulation through transcription factor sensitivity to chromatin	44
Means, mechanisms and consequences of adenine methylation in DNA	44
Gene regulatory network inference in the era of single-cell multi-omics	43
Spatial biology of cancer evolution	42
Engineering synthetic RNA devices for cell control	42
Dynamic alternative DNA structures in biology and disease	42
Origins of human disease: the chrono-epigenetic perspective	42
Sociotechnical safeguards for genomic data privacy	41
Disentangling host–microbiota complexity through hologenomics	41
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects	41
Context-specific Polycomb mechanisms in development	41
Discovering and validating cancer genetic dependencies: approaches and pitfalls	40
Examining the evidence for extracellular RNA function in mammals	39
Computational analysis of cancer genome sequencing data	38
HIV-1 and human genetic variation	38
RNA: a double-edged sword in genome maintenance	37
Engineering 3D genome organization	37