Nature Reviews Genetics

(The TQCC of Nature Reviews Genetics is 35. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-06-01 to 2024-06-01.)
Abiotic stress responses in plants809
The biological and clinical significance of emerging SARS-CoV-2 variants783
Deciphering cell–cell interactions and communication from gene expression620
mRNAs, proteins and the emerging principles of gene expression control619
Long-read human genome sequencing and its applications572
Drug delivery systems for RNA therapeutics477
The genetics of obesity: from discovery to biology466
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics454
Human organs-on-chips for disease modelling, drug development and personalized medicine420
RNA-binding proteins in human genetic disease372
The epitranscriptome beyond m6A367
Histone post-translational modifications — cause and consequence of genome function302
Testing at scale during the COVID-19 pandemic266
The evolving metabolic landscape of chromatin biology and epigenetics261
A decade of advances in transposon-insertion sequencing244
Methods and applications for single-cell and spatial multi-omics242
Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics233
Polygenic adaptation: a unifying framework to understand positive selection223
Measuring and interpreting transposable element expression218
Genetics meets proteomics: perspectives for large population-based studies208
Molecular mechanisms of transgenerational epigenetic inheritance205
Best practices for single-cell analysis across modalities191
Towards population-scale long-read sequencing174
The relationship between genome structure and function172
The epigenetic basis of cellular heterogeneity170
The emerging landscape of spatial profiling technologies166
Prime editing for precise and highly versatile genome manipulation160
Molecular and evolutionary processes generating variation in gene expression159
Gene therapy using haematopoietic stem and progenitor cells156
Reprogramming the genetic code152
COMPASS and SWI/SNF complexes in development and disease147
Transposable elements shape the evolution of mammalian development144
Emerging mechanisms of cell competition144
Enhancer redundancy in development and disease143
Alternative splicing as a source of phenotypic diversity142
Autophagy genes in biology and disease142
Measuring biological age using omics data139
The influence of evolutionary history on human health and disease137
Extreme heterogeneity of human mitochondrial DNA from organelles to populations130
The road ahead in genetics and genomics123
A new era in functional genomics screens119
Mining genomes to illuminate the specialized chemistry of life118
Navigating the pitfalls of applying machine learning in genomics118
Active turnover of DNA methylation during cell fate decisions118
Advancing the use of genome-wide association studies for drug repurposing117
Host–parasite co-evolution and its genomic signature112
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination107
Obtaining genetics insights from deep learning via explainable artificial intelligence105
Redefining fundamental concepts of transcription initiation in bacteria103
Host genetics and infectious disease: new tools, insights and translational opportunities103
Gene regulatory programmes of tissue regeneration101
Gene drives gaining speed99
Biological roles of adenine methylation in RNA94
Making sense of the ageing methylome93
Genetic load: genomic estimates and applications in non-model animals92
The Human Genome Project changed everything84
DNA methylation-based predictors of health: applications and statistical considerations84
Exploring human genomic diversity with gnomAD83
Clinical cancer genomic profiling82
microRNAs in action: biogenesis, function and regulation82
Epigenome plasticity in plants81
Single-cell atlases: shared and tissue-specific cell types across human organs79
Characterizing cis-regulatory elements using single-cell epigenomics79
The roles of microRNAs in mouse development75
Generation of extracellular morphogen gradients: the case for diffusion75
The importance of genomic variation for biodiversity, ecosystems and people74
Polygenic scores in biomedical research74
Responsible, practical genomic data sharing that accelerates research73
Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic73
African genetic diversity and adaptation inform a precision medicine agenda73
Temporal modelling using single-cell transcriptomics72
Primary cilia as dynamic and diverse signalling hubs in development and disease72
Genetic engineering of T cells for immunotherapy71
Advances and opportunities in malaria population genomics70
The human genetic epidemiology of COVID-1969
Mechanical regulation of chromatin and transcription68
Parental nucleosome segregation and the inheritance of cellular identity68
Genetic innovations in animal–microbe symbioses67
Interplay between chromatin marks in development and disease67
tRNA dysregulation and disease67
The potential of mitochondrial genome engineering64
Genetics of substance use disorders in the era of big data64
Gene regulatory network inference in the era of single-cell multi-omics63
Genetics of circadian rhythms and sleep in human health and disease63
Statistical mechanics meets single-cell biology63
Pharmacogenomics: current status and future perspectives62
Overlapping genes in natural and engineered genomes61
Probing the dynamic RNA structurome and its functions59
Organization and expression of the mammalian mitochondrial genome57
Testing the super-enhancer concept57
The spatial organization of transcriptional control57
Cross-species RNA-seq for deciphering host–microbe interactions56
Opportunities and challenges of macrogenetic studies56
Genetics of human telomere biology disorders53
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects52
Dynamic alternative DNA structures in biology and disease52
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo52
Theranostic cells: emerging clinical applications of synthetic biology52
Maternal H3K27me3-dependent autosomal and X chromosome imprinting52
Generating specificity in genome regulation through transcription factor sensitivity to chromatin51
Spatial biology of cancer evolution50
Means, mechanisms and consequences of adenine methylation in DNA50
Germline risk of clonal haematopoiesis50
Decoding disease: from genomes to networks to phenotypes48
Sociotechnical safeguards for genomic data privacy47
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies47
Origins of human disease: the chrono-epigenetic perspective46
Engineering synthetic RNA devices for cell control46
Context-specific Polycomb mechanisms in development46
Molecular mechanisms of environmental exposures and human disease46
Disentangling host–microbiota complexity through hologenomics44
Examining the evidence for extracellular RNA function in mammals43
Discovering and validating cancer genetic dependencies: approaches and pitfalls43
Computational analysis of cancer genome sequencing data43
Principles and methods for transferring polygenic risk scores across global populations40
HIV-1 and human genetic variation40
Engineering 3D genome organization38
Extrachromosomal DNA amplifications in cancer38
Mutation–selection balance and compensatory mechanisms in tumour evolution38
RNA: a double-edged sword in genome maintenance37
Non-coding RNAs in disease: from mechanisms to therapeutics37
Towards improved genetic diagnosis of human differences of sex development37
Variant calling and benchmarking in an era of complete human genome sequences35
New insights into genome folding by loop extrusion from inducible degron technologies35