OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Abiotic stress responses in plants	962
The biological and clinical significance of emerging SARS-CoV-2 variants	827
Deciphering cell–cell interactions and communication from gene expression	714
Drug delivery systems for RNA therapeutics	588
Human organs-on-chips for disease modelling, drug development and personalized medicine	560
The genetics of obesity: from discovery to biology	539
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics	517
The epitranscriptome beyond m6A	411
RNA-binding proteins in human genetic disease	410
Histone post-translational modifications — cause and consequence of genome function	396
Methods and applications for single-cell and spatial multi-omics	354
Best practices for single-cell analysis across modalities	289
Testing at scale during the COVID-19 pandemic	280
Molecular mechanisms of transgenerational epigenetic inheritance	251
Prime editing for precise and highly versatile genome manipulation	211
Autophagy genes in biology and disease	197
The emerging landscape of spatial profiling technologies	195
Towards population-scale long-read sequencing	191
The relationship between genome structure and function	189
The epigenetic basis of cellular heterogeneity	184
Measuring biological age using omics data	182
Alternative splicing as a source of phenotypic diversity	178
Molecular and evolutionary processes generating variation in gene expression	172
Gene therapy using haematopoietic stem and progenitor cells	170
Reprogramming the genetic code	166

Transposable elements shape the evolution of mammalian development	164
Enhancer redundancy in development and disease	163
microRNAs in action: biogenesis, function and regulation	154
The influence of evolutionary history on human health and disease	152
Advancing the use of genome-wide association studies for drug repurposing	150
Obtaining genetics insights from deep learning via explainable artificial intelligence	144
Navigating the pitfalls of applying machine learning in genomics	142
Mining genomes to illuminate the specialized chemistry of life	142
A new era in functional genomics screens	134
Biological roles of adenine methylation in RNA	131
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination	126
Genetic load: genomic estimates and applications in non-model animals	122
Host genetics and infectious disease: new tools, insights and translational opportunities	121
Gene drives gaining speed	117
Non-coding RNAs in disease: from mechanisms to therapeutics	114
Making sense of the ageing methylome	113
Primary cilia as dynamic and diverse signalling hubs in development and disease	109
DNA methylation-based predictors of health: applications and statistical considerations	107
Gene regulatory network inference in the era of single-cell multi-omics	104
Characterizing cis-regulatory elements using single-cell epigenomics	96
Clinical cancer genomic profiling	96
Epigenome plasticity in plants	93
Single-cell atlases: shared and tissue-specific cell types across human organs	92
Mechanical regulation of chromatin and transcription	89
Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic	89
Polygenic scores in biomedical research	88
Advances and opportunities in malaria population genomics	87
Generation of extracellular morphogen gradients: the case for diffusion	87
Temporal modelling using single-cell transcriptomics	86
Pharmacogenomics: current status and future perspectives	86
The human genetic epidemiology of COVID-19	84
African genetic diversity and adaptation inform a precision medicine agenda	83
Probing the dynamic RNA structurome and its functions	83
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects	82
Parental nucleosome segregation and the inheritance of cellular identity	81
The roles of microRNAs in mouse development	81
Genetic innovations in animal–microbe symbioses	81
tRNA dysregulation and disease	79
Genetic engineering of T cells for immunotherapy	79
Interplay between chromatin marks in development and disease	79
Dynamic alternative DNA structures in biology and disease	77
Genetics of circadian rhythms and sleep in human health and disease	77
The spatial organization of transcriptional control	77
Genetics of human telomere biology disorders	76
Organization and expression of the mammalian mitochondrial genome	74
Genetics of substance use disorders in the era of big data	73
Spatial biology of cancer evolution	72
Molecular mechanisms of environmental exposures and human disease	71
Statistical mechanics meets single-cell biology	71
The potential of mitochondrial genome engineering	70

Overlapping genes in natural and engineered genomes	67
Generating specificity in genome regulation through transcription factor sensitivity to chromatin	66
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	64
Cross-species RNA-seq for deciphering host–microbe interactions	64
Principles and methods for transferring polygenic risk scores across global populations	63
Testing the super-enhancer concept	61
Means, mechanisms and consequences of adenine methylation in DNA	61
Theranostic cells: emerging clinical applications of synthetic biology	60
Opportunities and challenges of macrogenetic studies	60
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	58
Sociotechnical safeguards for genomic data privacy	56
Germline risk of clonal haematopoiesis	54
Origins of human disease: the chrono-epigenetic perspective	53
Incongruence in the phylogenomics era	53
Engineering synthetic RNA devices for cell control	53
Context-specific Polycomb mechanisms in development	52
Computational analysis of cancer genome sequencing data	51
Disentangling host–microbiota complexity through hologenomics	51
RNA modifications in physiology and disease: towards clinical applications	50
Examining the evidence for extracellular RNA function in mammals	49
Decoding disease: from genomes to networks to phenotypes	49
Extrachromosomal DNA amplifications in cancer	49
Genomic newborn screening for rare diseases	48
Variant calling and benchmarking in an era of complete human genome sequences	47
HIV-1 and human genetic variation	47
Towards improved genetic diagnosis of human differences of sex development	45
New insights into genome folding by loop extrusion from inducible degron technologies	42
Engineering 3D genome organization	41
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	40
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	39
Mutation–selection balance and compensatory mechanisms in tumour evolution	39
Single-cell genomics meets human genetics	38
The origin of human mutation in light of genomic data	37
Soma-to-germline RNA communication	37
Genomic surveillance for antimicrobial resistance — a One Health perspective	36
Transposable elements in mammalian chromatin organization	36
Deafness: from genetic architecture to gene therapy	36
Microbiome epidemiology and association studies in human health	33
The nexus between RNA-binding proteins and their effectors	32
Sex-specific morphs: the genetics and evolution of intra-sexual variation	29
Purple Tomatoes, Black Rice and Food Security	28
Genetics of human brain development	27
The genetics of human performance	27
Towards a physical understanding of developmental patterning	27
Mendelian inheritance revisited: dominance and recessiveness in medical genetics	27
Transitioning single-cell genomics into the clinic	26
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	25
Regulation of the RNA polymerase II pre-initiation complex by its associated coactivators	25
Beyond assembly: the increasing flexibility of single-molecule sequencing technology	22
Functional genomics data: privacy risk assessment and technological mitigation	22
Perfect and imperfect views of ultraconserved sequences	22