Nature Reviews Genetics

(The TQCC of Nature Reviews Genetics is 32. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)
The biological and clinical significance of emerging SARS-CoV-2 variants649
Engineering adeno-associated virus vectors for gene therapy499
Abiotic stress responses in plants458
Deciphering cell–cell interactions and communication from gene expression420
mRNAs, proteins and the emerging principles of gene expression control415
Long-read human genome sequencing and its applications411
Determinants of enhancer and promoter activities of regulatory elements384
Regulation of gene expression by cis-acting long non-coding RNAs383
Context is everything: aneuploidy in cancer321
Methods for mapping 3D chromosome architecture316
Cell-free gene expression: an expanded repertoire of applications313
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics310
Lineage tracing meets single-cell omics: opportunities and challenges292
Structural variation in the sequencing era275
RNA-binding proteins in human genetic disease269
The epitranscriptome beyond m6A269
The genetics of obesity: from discovery to biology266
Harnessing genomics to fast-track genetic improvement in aquaculture222
Drug delivery systems for RNA therapeutics216
Testing at scale during the COVID-19 pandemic213
The evolving metabolic landscape of chromatin biology and epigenetics200
Human organs-on-chips for disease modelling, drug development and personalized medicine198
Mechanisms of early placental development in mouse and humans195
Towards a comprehensive catalogue of validated and target-linked human enhancers186
Transposable elements in human genetic disease182
Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics181
Polygenic adaptation: a unifying framework to understand positive selection175
A decade of advances in transposon-insertion sequencing172
Phylogenetic tree building in the genomic age171
Building machines with DNA molecules166
Measuring and interpreting transposable element expression163
The genetics of human ageing160
Pan-genomics in the human genome era152
Genetics meets proteomics: perspectives for large population-based studies144
Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire134
The epigenetic basis of cellular heterogeneity130
Histone post-translational modifications — cause and consequence of genome function126
Rare-variant collapsing analyses for complex traits: guidelines and applications126
Towards population-scale long-read sequencing121
Molecular mechanisms of transgenerational epigenetic inheritance120
Overcoming challenges and dogmas to understand the functions of pseudogenes119
The relationship between genome structure and function118
Reprogramming the genetic code118
Chromosome organization in bacteria: mechanistic insights into genome structure and function115
Emerging mechanisms of cell competition113
Molecular and evolutionary processes generating variation in gene expression112
Rights, interests and expectations: Indigenous perspectives on unrestricted access to genomic data110
Gene therapy using haematopoietic stem and progenitor cells108
Extreme heterogeneity of human mitochondrial DNA from organelles to populations107
Next-generation computational tools for interrogating cancer immunity104
COMPASS and SWI/SNF complexes in development and disease104
Enhancer redundancy in development and disease103
The influence of evolutionary history on human health and disease101
The road ahead in genetics and genomics99
Haematopoietic stem cell self-renewal in vivo and ex vivo96
Transposable elements shape the evolution of mammalian development96
Animal domestication in the era of ancient genomics95
Active turnover of DNA methylation during cell fate decisions92
Host–parasite co-evolution and its genomic signature86
Mining genomes to illuminate the specialized chemistry of life84
Mechanisms of tissue and cell-type specificity in heritable traits and diseases83
Gene regulatory programmes of tissue regeneration83
The emerging landscape of spatial profiling technologies83
Host genetics and infectious disease: new tools, insights and translational opportunities79
Redefining fundamental concepts of transcription initiation in bacteria79
Advancing the use of genome-wide association studies for drug repurposing69
A new era in functional genomics screens67
Electronic health records and polygenic risk scores for predicting disease risk66
The genomics of coloration provides insights into adaptive evolution66
A framework for an evidence-based gene list relevant to autism spectrum disorder66
Exploring human genomic diversity with gnomAD65
Navigating the pitfalls of applying machine learning in genomics64
A systems approach to infectious disease64
From molecules to populations: appreciating and estimating recombination rate variation64
The importance of genomic variation for biodiversity, ecosystems and people62
The roles of microRNAs in mouse development61
Clinical cancer genomic profiling59
The Human Genome Project changed everything59
Gene drives gaining speed57
Measuring biological age using omics data56
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination54
Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic53
Genetic engineering of T cells for immunotherapy52
Responsible, practical genomic data sharing that accelerates research52
Genetic load: genomic estimates and applications in non-model animals52
Conserved chromosomal functions of RNA interference52
African genetic diversity and adaptation inform a precision medicine agenda52
Making sense of the ageing methylome51
Epigenome plasticity in plants51
Parental nucleosome segregation and the inheritance of cellular identity50
Methods and applications for single-cell and spatial multi-omics48
Statistical mechanics meets single-cell biology47
Alternative splicing as a source of phenotypic diversity46
Prime editing for precise and highly versatile genome manipulation46
Single-cell atlases: shared and tissue-specific cell types across human organs46
Genetics of substance use disorders in the era of big data45
Generation of extracellular morphogen gradients: the case for diffusion44
Obtaining genetics insights from deep learning via explainable artificial intelligence44
Maternal H3K27me3-dependent autosomal and X chromosome imprinting43
Advances and opportunities in malaria population genomics43
Testing the super-enhancer concept43
Interplay between chromatin marks in development and disease43
The potential of mitochondrial genome engineering42
Mechanical regulation of chromatin and transcription42
Polygenic scores in biomedical research42
Beyond broad strokes: sociocultural insights from the study of ancient genomes41
Opportunities and challenges of macrogenetic studies39
Germline risk of clonal haematopoiesis38
DNA methylation-based predictors of health: applications and statistical considerations38
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo37
Overlapping genes in natural and engineered genomes37
Discovering and validating cancer genetic dependencies: approaches and pitfalls37
Theranostic cells: emerging clinical applications of synthetic biology37
Cross-species RNA-seq for deciphering host–microbe interactions37
Temporal modelling using single-cell transcriptomics37
Characterizing cis-regulatory elements using single-cell epigenomics36
Genetic innovations in animal–microbe symbioses36
The human genetic epidemiology of COVID-1935
Decoding disease: from genomes to networks to phenotypes32