Nature Reviews Genetics

Article	Citations
Tightening the (neural) net for protein structure prediction	1098
Single-cell expression profiling has its roots in in situ techniques	1039
Explaining the male bias in cancers	892
The different faces of transcription factor sensitivity	831
SCOPE-ing out eukaryotic 6mA	777
The evolution of modifier genes	637
Weaponized genomics: potential threats to international and human security	596
Disentangling population structure in marine species	488
Enhancing sustainable development through plant genetics	455
The evolution of DNA sequencing with microfluidics	449
Microorganisms as architects of a sustainable future	424
Imprinted genes and the manipulation of parenting in mammals	366
Harnessing deep learning for population genetic inference	340
Interrogating epigenetic mechanisms with chemically customized chromatin	323
Means, mechanisms and consequences of adenine methylation in DNA	313
Pleiotropy, epistasis and the genetic architecture of quantitative traits	271
Genomic insights into conifer evolution	265
Rapid pathogen surveillance: field-ready sequencing solutions	237
Unveiling the expanding protein universe of life	237
The origin of animals and fungi	230
Cis-regulatory elements at cellular resolution	225
Changes in cell-cycle rate drive diverging cell fates	216
Progress in toxicogenomics to protect human health	207
The evolutionary foundations of transcriptional regulation in animals	198
More than a decade of genetic research on the Denisovans	194

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	191
RNA polymerase II transcription compartments — from factories to condensates	190
Best practices for single-cell analysis across modalities	189
Mapping dosage	188
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	187
Mini-colons unlock tumour development outside the body	178
Layering epigenomic and transcriptomic space	174
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores	170
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	167
Genomic landscape of cancer in racially and ethnically diverse populations	167
Non-retroviral RNA viruses in eukaryotic genomes	156
Intrinsically disordered regions as facilitators of the transcription factor target search	149
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	149
Revealing gene function with statistical inference at single-cell resolution	147
Targeted genome-modification tools and their advanced applications in crop breeding	146
Epigenomes get personal	146
Predicting the effects of multigene perturbations	142
The hidden diversity of tumours	139
Swapping genes within and beyond our bodies	135
Mate choice through a genomic lens	133
Miller spreads and the power of observation	132
Single cell–cell communication	131
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	130
Retrotransposons: still mobile in humans	127
Fine-mapping causal variants — why finding ‘the one’ can be futile	122
Cohesin and CTCF emerge as building blocks of 3D genome structure	118
The origin and evolution of Wnt signalling	114
Redefining cellular reprogramming with advanced genomic technologies	104
CHIPping away at the genetic aetiology of clonal haematopoiesis	104
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	103
Clinical use of polygenic risk scores: current status, barriers and future directions	102
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	100
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	99
Genomic newborn screening for rare diseases	98
Global genomic diversity for All of Us	97
Social shifts in spiders	95
The final pieces of the human genome	94
Fitness effects of mutations throughout evolution	93
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	92
High-throughput biochemistry in RNA sequence space: predicting structure and function	90
Why geneticists should care about male infertility	82
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	81
Targeting and engineering long non-coding RNAs for cancer therapy	80
The diversification of methods for studying cell–cell interactions and communication	80
Effects of regulatory variants across pig tissues	78
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	77
Exon junction complex modulates m6A distribution	76
A digital marker for coronary artery disease	76
A whole-genome shotgun approach to human reference genome sequencing	74
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	73

Mosaic variegated aneuploidy in development, ageing and cancer	71
Sex-specific morphs: the genetics and evolution of intra-sexual variation	67
Microbial genomics for antimicrobial resistance ecology and action	64
The expanding diagnostic toolbox for rare genetic diseases	63
Navigating the pitfalls of mapping DNA and RNA modifications	62
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	61
Genetics of circadian rhythms and sleep in human health and disease	61
Genomic surveillance for antimicrobial resistance — a One Health perspective	57
Genomics for monitoring and understanding species responses to global climate change	57
Chromosomal instability as a driver of cancer progression	56
Divergence and conservation of the meiotic recombination machinery	56
Programmable DNA rearrangements using bridge RNAs	55
Using cell-free DNA to infer gene expression	54
SCENT defines non-coding disease mechanisms using single-cell multi-omics	51
The evolutionary tale of lactase persistence in humans	50
A developmental exit from totipotency	48
microRNAs as systemic regulators of ageing	46
How ancient genes form animal body plans	46
Prioritizing the detection of rare pathogenic variants in population screening	45
Harnessing evolution to infer protein networks	45
Functional synonymous mutations and their evolutionary consequences	43
New insights into genome folding by loop extrusion from inducible degron technologies	42
Biobanking with genetics shapes precision medicine and global health	42
Context-specific functions of chromatin remodellers in development and disease	40
Translating genomic advances into biodiversity conservation	39
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	36
Challenges and best practices in omics benchmarking	36
Author Correction: Transposable elements: McClintock’s legacy revisited	36
Global cooperation for a global pandemic	35
Packaging and delivery of genome-editing tools	34
Nascent transcription quantification with scFLUENT-seq	34
Towards improved fine-mapping of candidate causal variants	34
Integrating ELSI study teams in paediatric genomic research efforts	32
The FinnGen study: disease insights from a ‘bottlenecked’ population	32
The lives of cells, recorded	32
Context-specific regulatory variants in precision medicine and agriculture	32
Cell-type deconvolution methods for spatial transcriptomics	31
tRNA dysregulation and disease	29
The nexus between RNA-binding proteins and their effectors	29
Multifunctional histone variants in genome function	29
Methods and applications for single-cell and spatial multi-omics	28
Predicting gene expression from DNA sequence using deep learning models	28
In vivo editing of blood stem cells	27
Publisher Correction: Sociotechnical safeguards for genomic data privacy	26
Corrupted USB1 fails to process microRNAs required for blood development	26
Mary Lyon and the birth of X-inactivation research	26
Ancient migration and the modern genome	25
The continuum of transcription factor affinities	25
The regulatory landscape of chromatin accessibility	25
The genetic basis of human height	25
Single-cell genomics meets human genetics	23
Stem cell-derived organoid models: defying the Hayflick limit	22
De novo genes: from non-genic to genic	22
First glimpse of enhancers in gene regulation	22
Biological roles of adenine methylation in RNA	21
Spatial architecture of development and disease	19
The gene variant that helped put Latinxs in the 1000 genomes project	19
EpiDamID, a new single-cell multi-omics tool	19
Tandem repeats in the long-read sequencing era	18
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01	18
Endogenous retroviruses: unveiling new targets for cancer immunotherapy	17
Making sense of the polygenicity of complex traits	17
Genetic variation across and within individuals	17
Plant pattern recognition receptors: from evolutionary insight to engineering	16
The human genetic epidemiology of COVID-19	16
Forensic genetics in the omics era	16
Cytoplasmic mRNA decay and quality control machineries in eukaryotes	15
Tracking haplotypes to quantify genome erosion	15
Prime editing for precise and highly versatile genome manipulation	15
Sequencing-based analysis of microbiomes	15
BANKSY: scalable cell typing and domain segmentation for spatial omics	14
Current advances in primate genomics: novel approaches for understanding evolution and disease	14
Tracking protein binding to cis-regulatory elements with PRINT	13
Determining variant effects with pooled prime editing	13
DNA replication in cell fate reprogramming	13
How the waxing and waning of a mutation determines HIV treatment success	13
Nuclear genome influences mitochondrial DNA	13
Live long & prosper: evidence of evolutionary forces on lifespan	12
Methods and applications of genome-wide profiling of DNA damage and rare mutations	12
Cryptic initiation drives transcriptional junk in ageing	12

Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	11
Prompt-based bioinformatics: a new interface for multi-omics analysis	11
From clonality to complexity: a journey through microbial ecology and evolution	11
Genome-wide association testing beyond SNPs	11
Neighbourly modulation of transcript isoforms	10
Dissecting pleiotropy to gain mechanistic insights into human disease	10
Measuring the effects of regulatory variants in an endogenous context	10
Efficient computation reveals rare CRISPR–Cas systems	10
High-resolution imaging of RNA and proteins in thick tissues using cycleHCR	10
Plant pangenomes for crop improvement, biodiversity and evolution	10
Prospects for personalized cancer treatment in the era of single-cell sequencing	9
Spatial miRNomics: towards the integration of microRNAs in spatial biology	9
Tandem repeat variation of human centromeres	9
Chromatin loops facilitate co-regulation of paralogues	8
Deafness: from genetic architecture to gene therapy	8
Genetics of glycosylation in mammalian development and disease	8
DNA methylation-based predictors of health: applications and statistical considerations	8
Exploring biodiversity through museomics	8
An uneasy truce between population health and the gene pools within our bodies	7
Single-cell omics meets organoid cultures	7
Harnessing artificial intelligence to advance CRISPR-based genome editing technologies	7
Gregor Mendel and the concepts of dominance and recessiveness	7
The regulation and function of post-transcriptional RNA splicing	7
Harnessing lateral gene transfer and endosymbiosis for adaptation	7
Dynamic alternative DNA structures in biology and disease	7
Viral protection from viruses	7
Gene regulatory network inference in the era of single-cell multi-omics	7
Connecting noncoding variants to human traits	6
Publisher Correction: How germ granules promote germ cell fate	6
Transcriptional coupling of long-distance genes	6
RNA barcoding: the catalyst for the single-cell revolution	6
Detecting pregnancy complications from blood	6
Beyond genetics for cancer evolution	6
Methodological opportunities in genomic data analysis to advance health equity	6
Alu sequences promote long-distance relationships	5
An evolutionary continuum between non-coding and coding DNA	5
Systemic cell–cell communication in cancer	5
Pharmacogenomics: current status and future perspectives	5
To the rescue by blocking cryptic splicing	5
The design and engineering of synthetic genomes	5
Author Correction: Evolution and regulation of animal sex chromosomes	4
Drug delivery systems for RNA therapeutics	4
Charting the world’s microbiomes	4
Identifying off-target effects of genome editing with Tracking-seq	4
Context-specific Polycomb mechanisms in development	4
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	4
Understanding human placentation through spatial multiomics	4
Selection on structural variation in the amylase locus	4
An evolving hypothesis in autoimmune disease genetics	4
Genetics of human telomere biology disorders	4
Not all co-repressors are equal	4
Tuning mutagenesis by functional outcome	4
Engineering an oscillating gene circuit to delay cellular ageing	4
A TAD refined for gene regulation	3
CROWN-seq reveals m6Am landscapes and transcription start site diversity	3
Predictive evidence of the relevance of epigenetics to PTSD	3
The evolution of Mycobacterium tuberculosis as humans migrated out of Africa	3
The effects of loss of Y chromosome on male health	3
Revealing secrets of human genetic variation with population databases	3
Adapting systems biology to address the complexity of human disease in the single-cell era	3
Metabolic engineering of plant medicines	3
When cellular reprogramming meets AI: towards de novo cell design	3
Regulatory genomics at biobank scales	3
Sequencing and characterizing short tandem repeats in the human genome	3
SIMPLE-seq to decode DNA methylation dynamics in single cells	3
DNA Typewriter	3
Collaborating at the nexus of genomics, humanities, social science and stakeholders	3
Sex differences of oestradiol-mediated gene expression	3
Tracing the evolution of sequencing into the era of genomic medicine	3
The root cause of shoot-borne roots	3
A crossroads in the timeline of human evolution	3
Variant calling and benchmarking in an era of complete human genome sequences	3
Is enhancer-driven gene regulation all wrapped up?	3
Biomarker benchmarking	3
Nuclear receptors — studying genes to understand hormones	3
A call to action to scale up research and clinical genomic data sharing	3
RNA splicing — a central layer of gene regulation	3
From genome to drug: the hidden story of diversity	2
A TRIP to understand gene regulation	2
Molecular mechanisms of transgenerational epigenetic inheritance	2
Mapping trait-associated cells with spatial transcriptomics	2
From Mendel’s laws to non-Mendelian inheritance	2
Ethical governance for genomic data science in the cloud	2
The complex non-genetic inheritance of complex traits	2
Evolution and regulation of animal sex chromosomes	2
Locking in a synthetic genetic code	2
Non-coding RNAs in disease: from mechanisms to therapeutics	2
Regulatory genome annotation	2
Genome-scale models in human metabologenomics	2
Spatial epigenomics in single cells	2
X-linked competition — implications for human development and disease	2
Thoughts on a legacy	2
A diverse and inclusive human pangenome	2
Stochastic transitions as a major source of cancer heterogeneity	2
Temporal modelling using single-cell transcriptomics	2