Nature Reviews Genetics

Article	Citations
The biological and clinical significance of emerging SARS-CoV-2 variants	756
Abiotic stress responses in plants	718
mRNAs, proteins and the emerging principles of gene expression control	576
Deciphering cell–cell interactions and communication from gene expression	565
Long-read human genome sequencing and its applications	537
Drug delivery systems for RNA therapeutics	426
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics	418
The genetics of obesity: from discovery to biology	414
Human organs-on-chips for disease modelling, drug development and personalized medicine	367
RNA-binding proteins in human genetic disease	354
The epitranscriptome beyond m6A	345
Harnessing genomics to fast-track genetic improvement in aquaculture	270
Histone post-translational modifications — cause and consequence of genome function	259
The evolving metabolic landscape of chromatin biology and epigenetics	254
Testing at scale during the COVID-19 pandemic	249
A decade of advances in transposon-insertion sequencing	227
Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics	225
Phylogenetic tree building in the genomic age	221
Measuring and interpreting transposable element expression	208
Polygenic adaptation: a unifying framework to understand positive selection	207
Methods and applications for single-cell and spatial multi-omics	196
Genetics meets proteomics: perspectives for large population-based studies	188
Molecular mechanisms of transgenerational epigenetic inheritance	181
Towards population-scale long-read sequencing	164
The epigenetic basis of cellular heterogeneity	161

The relationship between genome structure and function	159
The emerging landscape of spatial profiling technologies	150
Molecular and evolutionary processes generating variation in gene expression	148
Reprogramming the genetic code	147
Gene therapy using haematopoietic stem and progenitor cells	147
Best practices for single-cell analysis across modalities	141
COMPASS and SWI/SNF complexes in development and disease	139
Emerging mechanisms of cell competition	138
Prime editing for precise and highly versatile genome manipulation	137
Transposable elements shape the evolution of mammalian development	135
Rights, interests and expectations: Indigenous perspectives on unrestricted access to genomic data	133
The influence of evolutionary history on human health and disease	130
Enhancer redundancy in development and disease	129
Extreme heterogeneity of human mitochondrial DNA from organelles to populations	126
Alternative splicing as a source of phenotypic diversity	125
The road ahead in genetics and genomics	119
Measuring biological age using omics data	117
Haematopoietic stem cell self-renewal in vivo and ex vivo	116
Animal domestication in the era of ancient genomics	115
Active turnover of DNA methylation during cell fate decisions	114
Navigating the pitfalls of applying machine learning in genomics	110
Mining genomes to illuminate the specialized chemistry of life	110
Host–parasite co-evolution and its genomic signature	108
Autophagy genes in biology and disease	108
Advancing the use of genome-wide association studies for drug repurposing	102
A new era in functional genomics screens	101
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination	101
Redefining fundamental concepts of transcription initiation in bacteria	98
Gene regulatory programmes of tissue regeneration	98
Host genetics and infectious disease: new tools, insights and translational opportunities	96
Gene drives gaining speed	91
Obtaining genetics insights from deep learning via explainable artificial intelligence	88
The genomics of coloration provides insights into adaptive evolution	83
A framework for an evidence-based gene list relevant to autism spectrum disorder	82
Exploring human genomic diversity with gnomAD	82
Making sense of the ageing methylome	82
Genetic load: genomic estimates and applications in non-model animals	79
From molecules to populations: appreciating and estimating recombination rate variation	79
The Human Genome Project changed everything	77
The importance of genomic variation for biodiversity, ecosystems and people	75
Clinical cancer genomic profiling	75
Biological roles of adenine methylation in RNA	74
Single-cell atlases: shared and tissue-specific cell types across human organs	73
Epigenome plasticity in plants	73
The roles of microRNAs in mouse development	71
Characterizing cis-regulatory elements using single-cell epigenomics	71
Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic	70
Generation of extracellular morphogen gradients: the case for diffusion	68
African genetic diversity and adaptation inform a precision medicine agenda	67
Temporal modelling using single-cell transcriptomics	66

Polygenic scores in biomedical research	66
DNA methylation-based predictors of health: applications and statistical considerations	66
Responsible, practical genomic data sharing that accelerates research	66
Genetic engineering of T cells for immunotherapy	65
The human genetic epidemiology of COVID-19	64
Interplay between chromatin marks in development and disease	63
Parental nucleosome segregation and the inheritance of cellular identity	61
Mechanical regulation of chromatin and transcription	61
Genetic innovations in animal–microbe symbioses	60
Statistical mechanics meets single-cell biology	60
Genetics of substance use disorders in the era of big data	59
The potential of mitochondrial genome engineering	58
Overlapping genes in natural and engineered genomes	57
Advances and opportunities in malaria population genomics	57
microRNAs in action: biogenesis, function and regulation	56
Primary cilia as dynamic and diverse signalling hubs in development and disease	56
Genetics of circadian rhythms and sleep in human health and disease	53
Cross-species RNA-seq for deciphering host–microbe interactions	53
Genetics of human telomere biology disorders	52
tRNA dysregulation and disease	52
The spatial organization of transcriptional control	52
Testing the super-enhancer concept	52
Maternal H3K27me3-dependent autosomal and X chromosome imprinting	51
Opportunities and challenges of macrogenetic studies	51
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	50
Pharmacogenomics: current status and future perspectives	50
Theranostic cells: emerging clinical applications of synthetic biology	48
Germline risk of clonal haematopoiesis	47
Probing the dynamic RNA structurome and its functions	46
Organization and expression of the mammalian mitochondrial genome	45
Decoding disease: from genomes to networks to phenotypes	45
Generating specificity in genome regulation through transcription factor sensitivity to chromatin	44
Means, mechanisms and consequences of adenine methylation in DNA	44
Gene regulatory network inference in the era of single-cell multi-omics	43
Spatial biology of cancer evolution	42
Engineering synthetic RNA devices for cell control	42
Dynamic alternative DNA structures in biology and disease	42
Origins of human disease: the chrono-epigenetic perspective	42
Sociotechnical safeguards for genomic data privacy	41
Disentangling host–microbiota complexity through hologenomics	41
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects	41
Context-specific Polycomb mechanisms in development	41
Discovering and validating cancer genetic dependencies: approaches and pitfalls	40
Examining the evidence for extracellular RNA function in mammals	39
HIV-1 and human genetic variation	38
Computational analysis of cancer genome sequencing data	38
Engineering 3D genome organization	37
RNA: a double-edged sword in genome maintenance	37
Towards improved genetic diagnosis of human differences of sex development	35
Mutation–selection balance and compensatory mechanisms in tumour evolution	35
Extrachromosomal DNA amplifications in cancer	35
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	34
Molecular mechanisms of environmental exposures and human disease	31
Soma-to-germline RNA communication	30
New insights into genome folding by loop extrusion from inducible degron technologies	30
How digital tools can advance quality and equity in genomic medicine	29
Variant calling and benchmarking in an era of complete human genome sequences	28
Genomic newborn screening for rare diseases	27
Principles and methods for transferring polygenic risk scores across global populations	26
The genetics of human performance	25
The origin of human mutation in light of genomic data	25
Purple Tomatoes, Black Rice and Food Security	24
Transposable elements in mammalian chromatin organization	21
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	21
Deafness: from genetic architecture to gene therapy	20
Single-cell genomics meets human genetics	18
Incongruence in the phylogenomics era	18
Non-coding RNAs in disease: from mechanisms to therapeutics	18
The nexus between RNA-binding proteins and their effectors	18
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	17
Microbiome epidemiology and association studies in human health	17
Sex-specific morphs: the genetics and evolution of intra-sexual variation	17
Perfect and imperfect views of ultraconserved sequences	16
Reaching completion for GTEx	16
Mendelian inheritance revisited: dominance and recessiveness in medical genetics	16
African ancient DNA research requires robust ethics and permission protocols	15
Functional genomics data: privacy risk assessment and technological mitigation	14
Towards a physical understanding of developmental patterning	14
From systems to structure — using genetic data to model protein structures	14
Transitioning single-cell genomics into the clinic	14

Widespread occurrence of circular RNA in eukaryotes	14
Biparental inheritance of mitochondrial DNA revisited	13
Current advances in primate genomics: novel approaches for understanding evolution and disease	13
Genetics of human brain development	12
Repetitive DNA: genomic dark matter matters	12
Regulation of the RNA polymerase II pre-initiation complex by its associated coactivators	12
The TOPMed genomic resource for human health	12
Opportunities and challenges for the use of common controls in sequencing studies	12
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	11
Addressing health disparities in cancer with genomics	11
Beyond assembly: the increasing flexibility of single-molecule sequencing technology	11
Genetic determinism, essentialism and reductionism: semantic clarity for contested science	10
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	10
RNA modifications in physiology and disease: towards clinical applications	10
Genomic surveillance for antimicrobial resistance — a One Health perspective	10
Fine-mapping causal variants — why finding ‘the one’ can be futile	9
Interpreting non-coding disease-associated human variants using single-cell epigenomics	9
Effective study design for comparative functional genomics	9
Navigating the pitfalls of mapping DNA and RNA modifications	8
The mutation rate as an evolving trait	8
Gregor Mendel and the concepts of dominance and recessiveness	7
Shaping faces: genetic and epigenetic control of craniofacial morphogenesis	7
SHARE-seq reveals chromatin potential	7
Prioritizing the detection of rare pathogenic variants in population screening	7
The magic and meaning of Mendel’s miracle	6
The power of large-scale exome sequencing	6
Navigating bottlenecks and trade-offs in genomic data analysis	6
Computational methods for analysing multiscale 3D genome organization	5
CRISPR–Cas13 targets circRNAs	5
Author Correction: Polygenic adaptation: a unifying framework to understand positive selection	5
Implications of mitochondrial DNA mutations in human induced pluripotent stem cells	5
Steering and controlling evolution — from bioengineering to fighting pathogens	5
Divergence and conservation of the meiotic recombination machinery	4
Genomics for monitoring and understanding species responses to global climate change	4
Publisher Correction: The genomics of coloration provides insights into adaptive evolution	4
Getting organized with non-coding RNAs	4
Resolving the roles of structural variants	4
High-throughput biochemistry in RNA sequence space: predicting structure and function	4
The FinnGen study: disease insights from a ‘bottlenecked’ population	4
The transition from genomics to phenomics in personalized population health	4
Detecting pregnancy complications from blood	4
Genomic prediction of neoantigens: immunogenomics before NGS	4
Mitochondrial DNA variants in genomic data: diagnostic uplifts and predictive implications	3
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	3
Author Correction: The evolving metabolic landscape of chromatin biology and epigenetics	3
Rethinking nomenclature for interspecies cell fusions	3
Pioneer factors — key regulators of chromatin and gene expression	3
Genome-scale single-cell CRISPR screens	3
Publisher Correction: The relationship between genome structure and function	3
Inborn errors of immunity: an expanding universe of disease and genetic architecture	3
Harnessing deep learning for population genetic inference	3
Author Correction: Emerging mechanisms of cell competition	3
Mate choice through a genomic lens	3
Homozygosity mapping: a game-changer for autosomal recessive diseases	3
From LD-based mapping to GWAS	3
Context-specific functions of chromatin remodellers in development and disease	3
Host genetics of coronavirus infection	3
Imprinted genes and the manipulation of parenting in mammals	2
A body-wide view of somatic mutations	2
Traversing industry and academia in biomedicine: the best of both worlds?	2
Quantifying gene duplication	2
CRISPR editing within microbial communities	2
Publisher Correction: Sociotechnical safeguards for genomic data privacy	2
Predicting variant pathogenicity with AlphaMissense	2
Reverting to old theories of ageing with new evidence for the role of somatic mutations	2
Dissecting the genetics of ovarian ageing	2
A platform for RNA virus cloning	2
Chromosome structure at micro-scale	2
Reconciliation between high yield and disease resistance	2
Aneuploidy in the driving seat	2
Capturing transposases for new proteins	2
Pan-cancer atlas of intratumour heterogeneity	2
Base editing takes a shot at disease in non-human primates	2
microRNAs as systemic regulators of ageing	2
Genomic outbreak surveillance in resource-poor settings	2
Complex targeted sequencing in real time	2
The final pieces of the human genome	2
New tools for transcriptome-wide mapping of m6A	2
Layering epigenomic and transcriptomic space	2
From Mendel to a Mendelian disorder: towards a cure for sickle cell disease	2
Genomic insights into conifer evolution	2
More than a decade of genetic research on the Denisovans	1
African cattle adaptations	1
Disentangling population structure in marine species	1
Giant genomes of lungfish	1
First glimpse of enhancers in gene regulation	1
Spatial epigenomics in single cells	1
Challenges and best practices in omics benchmarking	1
Human cell-lineage imbalances	1
Publisher Correction: Mutation–selection balance and compensatory mechanisms in tumour evolution	1
Vavilov’s law and phenotypes across species	1
The origin of animals and fungi	1
Interrogating epigenetic mechanisms with chemically customized chromatin	1
Transposable elements: McClintock’s legacy revisited	1
Stem cell-derived organoid models: defying the Hayflick limit	1