Nature Reviews Genetics

Article	Citations
Tightening the (neural) net for protein structure prediction	1013
Single-cell expression profiling has its roots in in situ techniques	985
Explaining the male bias in cancers	818
The different faces of transcription factor sensitivity	782
SCOPE-ing out eukaryotic 6mA	709
The evolution of modifier genes	583
Disentangling population structure in marine species	534
Microorganisms as architects of a sustainable future	454
Interrogating epigenetic mechanisms with chemically customized chromatin	425
Harnessing deep learning for population genetic inference	420
Enhancing sustainable development through plant genetics	387
Getting organized with non-coding RNAs	341
Imprinted genes and the manipulation of parenting in mammals	317
The evolution of DNA sequencing with microfluidics	287
Weaponized genomics: potential threats to international and human security	277
Pleiotropy, epistasis and the genetic architecture of quantitative traits	252
Means, mechanisms and consequences of adenine methylation in DNA	244
Genomic insights into conifer evolution	217
Unveiling the expanding protein universe of life	215
Rapid pathogen surveillance: field-ready sequencing solutions	214
The origin of animals and fungi	208
Cis-regulatory elements at cellular resolution	207
Changes in cell-cycle rate drive diverging cell fates	203
The evolutionary foundations of transcriptional regulation in animals	199
RNA polymerase II transcription compartments — from factories to condensates	187

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	181
Progress in toxicogenomics to protect human health	180
Best practices for single-cell analysis across modalities	179
More than a decade of genetic research on the Denisovans	178
Non-retroviral RNA viruses in eukaryotic genomes	169
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores	168
Mapping dosage	165
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	160
Mini-colons unlock tumour development outside the body	159
Genomic landscape of cancer in racially and ethnically diverse populations	158
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	156
CRISPR editing within microbial communities	141
Targeted genome-modification tools and their advanced applications in crop breeding	140
Revealing gene function with statistical inference at single-cell resolution	137
Intrinsically disordered regions as facilitators of the transcription factor target search	136
Layering epigenomic and transcriptomic space	136
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	132
Epigenomes get personal	129
Predicting the effects of multigene perturbations	128
The hidden diversity of tumours	124
Swapping genes within and beyond our bodies	120
Mate choice through a genomic lens	116
Miller spreads and the power of observation	115
Cohesin and CTCF emerge as building blocks of 3D genome structure	113
Single cell–cell communication	113
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	112
Redefining cellular reprogramming with advanced genomic technologies	108
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	105
CHIPping away at the genetic aetiology of clonal haematopoiesis	104
Fine-mapping causal variants — why finding ‘the one’ can be futile	99
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	97
Retrotransposons: still mobile in humans	94
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	91
Clinical use of polygenic risk scores: current status, barriers and future directions	91
The origin and evolution of Wnt signalling	89
Global genomic diversity for All of Us	88
Social shifts in spiders	88
Genomic newborn screening for rare diseases	88
Fitness effects of mutations throughout evolution	85
The final pieces of the human genome	85
Targeting and engineering long non-coding RNAs for cancer therapy	84
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	83
The diversification of methods for studying cell–cell interactions and communication	74
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	73
Why geneticists should care about male infertility	72
High-throughput biochemistry in RNA sequence space: predicting structure and function	71
The potential of mitochondrial genome engineering	71
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	70
Effects of regulatory variants across pig tissues	70
Exon junction complex modulates m6A distribution	69

A digital marker for coronary artery disease	68
A whole-genome shotgun approach to human reference genome sequencing	67
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	66
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	65
Genetics of circadian rhythms and sleep in human health and disease	63
Mosaic variegated aneuploidy in development, ageing and cancer	58
Divergence and conservation of the meiotic recombination machinery	58
Sex-specific morphs: the genetics and evolution of intra-sexual variation	55
Genomic surveillance for antimicrobial resistance — a One Health perspective	54
Navigating the pitfalls of mapping DNA and RNA modifications	53
The expanding diagnostic toolbox for rare genetic diseases	53
Genomics for monitoring and understanding species responses to global climate change	52
Chromosomal instability as a driver of cancer progression	51
Laterally mobile chromosomes	49
Using cell-free DNA to infer gene expression	49
Programmable DNA rearrangements using bridge RNAs	49
SCENT defines non-coding disease mechanisms using single-cell multi-omics	46
The evolutionary tale of lactase persistence in humans	46
microRNAs as systemic regulators of ageing	42
A developmental exit from totipotency	42
Prioritizing the detection of rare pathogenic variants in population screening	41
Biobanking with genetics shapes precision medicine and global health	40
How ancient genes form animal body plans	40
Translating genomic advances into biodiversity conservation	39
Challenges and best practices in omics benchmarking	39
New insights into genome folding by loop extrusion from inducible degron technologies	39
Functional synonymous mutations and their evolutionary consequences	37
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	35
Context-specific functions of chromatin remodellers in development and disease	35
Author Correction: Transposable elements: McClintock’s legacy revisited	34
Global cooperation for a global pandemic	33
Context-specific regulatory variants in precision medicine and agriculture	33
The FinnGen study: disease insights from a ‘bottlenecked’ population	32
Towards improved fine-mapping of candidate causal variants	31
Predicting gene expression from DNA sequence using deep learning models	30
The nexus between RNA-binding proteins and their effectors	30
Cell-type deconvolution methods for spatial transcriptomics	29
Multifunctional histone variants in genome function	29
Packaging and delivery of genome-editing tools	29
Integrating ELSI study teams in paediatric genomic research efforts	27
The lives of cells, recorded	27
tRNA dysregulation and disease	26
Methods and applications for single-cell and spatial multi-omics	26
In vivo editing of blood stem cells	25
Homozygosity mapping: a game-changer for autosomal recessive diseases	24
Mary Lyon and the birth of X-inactivation research	23
Publisher Correction: Sociotechnical safeguards for genomic data privacy	23
The regulatory landscape of chromatin accessibility	22
Corrupted USB1 fails to process microRNAs required for blood development	22
Ancient migration and the modern genome	22
First glimpse of enhancers in gene regulation	21
Spatial architecture of development and disease	20
The continuum of transcription factor affinities	20
The genetic basis of human height	19
De novo genes: from non-genic to genic	19
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	19
Stem cell-derived organoid models: defying the Hayflick limit	19
Single-cell genomics meets human genetics	18
Biological roles of adenine methylation in RNA	18
Impact of genetic ancestry on viral infection response	17
EpiDamID, a new single-cell multi-omics tool	17
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01	16
The gene variant that helped put Latinxs in the 1000 genomes project	16
Tandem repeats in the long-read sequencing era	16
Making sense of the polygenicity of complex traits	15
Endogenous retroviruses: unveiling new targets for cancer immunotherapy	15
Genetic variation across and within individuals	15
Cytoplasmic mRNA decay and quality control machineries in eukaryotes	14
The human genetic epidemiology of COVID-19	14
Tracking haplotypes to quantify genome erosion	13
Forensic genetics in the omics era	13
Plant pattern recognition receptors: from evolutionary insight to engineering	13
Sequencing-based analysis of microbiomes	13
BANKSY: scalable cell typing and domain segmentation for spatial omics	13
Prime editing for precise and highly versatile genome manipulation	13
DNA replication in cell fate reprogramming	12
Current advances in primate genomics: novel approaches for understanding evolution and disease	12
Tracking protein binding to cis-regulatory elements with PRINT	11
Prompt-based bioinformatics: a new interface for multi-omics analysis	11
How the waxing and waning of a mutation determines HIV treatment success	10

From clonality to complexity: a journey through microbial ecology and evolution	10
Determining variant effects with pooled prime editing	10
Nuclear genome influences mitochondrial DNA	10
Plant pangenomes for crop improvement, biodiversity and evolution	9
Genome-wide association testing beyond SNPs	9
Cryptic initiation drives transcriptional junk in ageing	9
Live long & prosper: evidence of evolutionary forces on lifespan	9
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	9
Methods and applications of genome-wide profiling of DNA damage and rare mutations	9
Efficient computation reveals rare CRISPR–Cas systems	9
Neighbourly modulation of transcript isoforms	8
Measuring the effects of regulatory variants in an endogenous context	8
High-resolution imaging of RNA and proteins in thick tissues using cycleHCR	8
Chromatin loops facilitate co-regulation of paralogues	7
DNA methylation-based predictors of health: applications and statistical considerations	7
Genetics of glycosylation in mammalian development and disease	7
Tandem repeat variation of human centromeres	7
Spatial miRNomics: towards the integration of microRNAs in spatial biology	7
Deafness: from genetic architecture to gene therapy	7
Prospects for personalized cancer treatment in the era of single-cell sequencing	7
Gregor Mendel and the concepts of dominance and recessiveness	6
Exploring biodiversity through museomics	6
An uneasy truce between population health and the gene pools within our bodies	6
The regulation and function of post-transcriptional RNA splicing	6
Gene regulatory network inference in the era of single-cell multi-omics	6
Harnessing lateral gene transfer and endosymbiosis for adaptation	6
Dynamic alternative DNA structures in biology and disease	6
Publisher Correction: How germ granules promote germ cell fate	5
Transcriptional coupling of long-distance genes	5
RNA barcoding: the catalyst for the single-cell revolution	5
Single-cell omics meets organoid cultures	5
Beyond genetics for cancer evolution	5
Viral protection from viruses	5
An evolutionary continuum between non-coding and coding DNA	5
Detecting pregnancy complications from blood	4
Alu sequences promote long-distance relationships	4
Author Correction: Evolution and regulation of animal sex chromosomes	4
Drug delivery systems for RNA therapeutics	4
To the rescue by blocking cryptic splicing	4
The design and engineering of synthetic genomes	4
Systemic cell–cell communication in cancer	4
Genetics of human telomere biology disorders	4
Navigating the pitfalls of applying machine learning in genomics	4
Methodological opportunities in genomic data analysis to advance health equity	4
Pharmacogenomics: current status and future perspectives	4
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	4
Context-specific Polycomb mechanisms in development	4
An evolving hypothesis in autoimmune disease genetics	4
Connecting noncoding variants to human traits	4
A TAD refined for gene regulation	3
The root cause of shoot-borne roots	3
Tracing the evolution of sequencing into the era of genomic medicine	3
Not all co-repressors are equal	3
RNA splicing — a central layer of gene regulation	3
Collaborating at the nexus of genomics, humanities, social science and stakeholders	3
Revealing secrets of human genetic variation with population databases	3
Regulatory genomics at biobank scales	3
Variant calling and benchmarking in an era of complete human genome sequences	3
Tuning mutagenesis by functional outcome	3
Adapting systems biology to address the complexity of human disease in the single-cell era	3
Selection on structural variation in the amylase locus	3
Engineering an oscillating gene circuit to delay cellular ageing	3
Identifying off-target effects of genome editing with Tracking-seq	3
A call to action to scale up research and clinical genomic data sharing	3
The effects of loss of Y chromosome on male health	3
Predictive evidence of the relevance of epigenetics to PTSD	3
A crossroads in the timeline of human evolution	3
Is enhancer-driven gene regulation all wrapped up?	3
Metabolic engineering of plant medicines	3
When cellular reprogramming meets AI: towards de novo cell design	3
Understanding human placentation through spatial multiomics	3
Charting the world’s microbiomes	3
Sex differences of oestradiol-mediated gene expression	3
CROWN-seq reveals m6Am landscapes and transcription start site diversity	3
Nuclear receptors — studying genes to understand hormones	3
DNA Typewriter	3
The evolution of Mycobacterium tuberculosis as humans migrated out of Africa	3
From genome to drug: the hidden story of diversity	2
Towards gene therapy for Tay-Sachs disease	2
Human organs-on-chips for disease modelling, drug development and personalized medicine	2
Gene therapy for deafness: we can do more	2
Ethical governance for genomic data science in the cloud	2
Genome-scale models in human metabologenomics	2
Mapping vertebrate brain evolution	2
Measuring biological age using omics data	2
Stochastic transitions as a major source of cancer heterogeneity	2
Computational analysis of cancer genome sequencing data	2
Spatial epigenomics in single cells	2
Author Correction: Functional genomics data: privacy risk assessment and technological mitigation	2
Genetic prediction of multi-omic traits	2
Illuminating the human yolk sac through single-cell omics	2
From Mendel’s laws to non-Mendelian inheritance	2
Temporal modelling using single-cell transcriptomics	2
Computational methods for analysing multiscale 3D genome organization	2
Target-directed microRNA degradation in Drosophila	2