Nature Reviews Genetics

Article	Citations
The different faces of transcription factor sensitivity	1436
Explaining the male bias in cancers	922
Single-cell expression profiling has its roots in in situ techniques	911
Tightening the (neural) net for protein structure prediction	900
Disentangling population structure in marine species	801
Enhancing sustainable development through plant genetics	704
SCOPE-ing out eukaryotic 6mA	694
Weaponized genomics: potential threats to international and human security	615
The evolution of modifier genes	492
Getting organized with non-coding RNAs	426
Imprinted genes and the manipulation of parenting in mammals	406
The evolution of DNA sequencing with microfluidics	385
Harnessing deep learning for population genetic inference	366
Pleiotropy, epistasis and the genetic architecture of quantitative traits	345
Interrogating epigenetic mechanisms with chemically customized chromatin	296
Means, mechanisms and consequences of adenine methylation in DNA	290
Genomic insights into conifer evolution	235
Unveiling the expanding protein universe of life	233
Rapid pathogen surveillance: field-ready sequencing solutions	231
The evolutionary foundations of transcriptional regulation in animals	219
The origin of animals and fungi	217
Changes in cell-cycle rate drive diverging cell fates	203
Progress in toxicogenomics to protect human health	194
RNA polymerase II transcription compartments — from factories to condensates	192
More than a decade of genetic research on the Denisovans	191

Testing the super-enhancer concept	183
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	181
Best practices for single-cell analysis across modalities	169
Abiotic stress responses in plants	169
CRISPR editing within microbial communities	164
Mapping dosage	163
Genomic landscape of cancer in racially and ethnically diverse populations	163
Aneuploidy in the driving seat	159
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	155
Mini-colons unlock tumour development outside the body	154
Revealing gene function with statistical inference at single-cell resolution	148
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	146
Layering epigenomic and transcriptomic space	143
Intrinsically disordered regions as facilitators of the transcription factor target search	142
Non-retroviral RNA viruses in eukaryotic genomes	133
Targeted genome-modification tools and their advanced applications in crop breeding	131
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	129
Predicting the effects of multigene perturbations	128
Epigenomes get personal	127
The hidden diversity of tumours	126
CHIPping away at the genetic aetiology of clonal haematopoiesis	125
Miller spreads and the power of observation	124
Swapping genes within and beyond our bodies	121
Mate choice through a genomic lens	120
Fine-mapping causal variants — why finding ‘the one’ can be futile	117
Single cell–cell communication	107
Cohesin and CTCF emerge as building blocks of 3D genome structure	107
Retrotransposons: still mobile in humans	106
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	106
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	105
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	103
The origin and evolution of Wnt signalling	102
Genomic newborn screening for rare diseases	101
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	89
Social shifts in spiders	88
The final pieces of the human genome	88
Why geneticists should care about male infertility	87
Global genomic diversity for All of Us	87
Fitness effects of mutations throughout evolution	86
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	85
The potential of mitochondrial genome engineering	84
High-throughput biochemistry in RNA sequence space: predicting structure and function	82
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	81
Effects of regulatory variants across pig tissues	80
The diversification of methods for studying cell–cell interactions and communication	80
Targeting and engineering long non-coding RNAs for cancer therapy	80
Exon junction complex modulates m6A distribution	77
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	77
A digital marker for coronary artery disease	73
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	71

A whole-genome shotgun approach to human reference genome sequencing	71
Sex-specific morphs: the genetics and evolution of intra-sexual variation	70
Divergence and conservation of the meiotic recombination machinery	70
Genomic surveillance for antimicrobial resistance — a One Health perspective	69
Mosaic variegated aneuploidy in development, ageing and cancer	69
Genomics for monitoring and understanding species responses to global climate change	68
Navigating the pitfalls of mapping DNA and RNA modifications	67
Genetics of circadian rhythms and sleep in human health and disease	66
The expanding diagnostic toolbox for rare genetic diseases	63
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	62
Chromosomal instability as a driver of cancer progression	59
Laterally mobile chromosomes	59
Using cell-free DNA to infer gene expression	58
The evolutionary tale of lactase persistence in humans	54
Programmable DNA rearrangements using bridge RNAs	54
SCENT defines non-coding disease mechanisms using single-cell multi-omics	54
A developmental exit from totipotency	53
microRNAs as systemic regulators of ageing	53
Functional synonymous mutations and their evolutionary consequences	51
Challenges and best practices in omics benchmarking	49
Context-specific functions of chromatin remodellers in development and disease	46
New insights into genome folding by loop extrusion from inducible degron technologies	45
How ancient genes form animal body plans	44
Biobanking with genetics shapes precision medicine and global health	44
Translating genomic advances into biodiversity conservation	44
Prioritizing the detection of rare pathogenic variants in population screening	44
Author Correction: Transposable elements: McClintock’s legacy revisited	41
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	39
Context-specific regulatory variants in precision medicine and agriculture	37
Global cooperation for a global pandemic	37
Integrating ELSI study teams in paediatric genomic research efforts	36
The FinnGen study: disease insights from a ‘bottlenecked’ population	35
Cell-type deconvolution methods for spatial transcriptomics	34
The lives of cells, recorded	34
Predicting gene expression from DNA sequence using deep learning models	34
Packaging and delivery of genome-editing tools	34
Multifunctional histone variants in genome function	33
Methods and applications for single-cell and spatial multi-omics	33
tRNA dysregulation and disease	32
The nexus between RNA-binding proteins and their effectors	32
In vivo editing of blood stem cells	32
Homozygosity mapping: a game-changer for autosomal recessive diseases	31
The continuum of transcription factor affinities	30
Corrupted USB1 fails to process microRNAs required for blood development	30
Mary Lyon and the birth of X-inactivation research	30
Publisher Correction: Sociotechnical safeguards for genomic data privacy	30
Ancient migration and the modern genome	29
The regulatory landscape of chromatin accessibility	27
The genetic basis of human height	27
First glimpse of enhancers in gene regulation	26
Stem cell-derived organoid models: defying the Hayflick limit	26
De novo genes: from non-genic to genic	25
Single-cell genomics meets human genetics	25
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	23
Biological roles of adenine methylation in RNA	22
EpiDamID, a new single-cell multi-omics tool	21
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01	21
Impact of genetic ancestry on viral infection response	20
The gene variant that helped put Latinxs in the 1000 genomes project	20
Tandem repeats in the long-read sequencing era	19
Making sense of the polygenicity of complex traits	18
Cytoplasmic mRNA decay and quality control machineries in eukaryotes	18
Endogenous retroviruses: unveiling new targets for cancer immunotherapy	17
Genetic variation across and within individuals	17
Publisher Correction: The relationship between genome structure and function	16
Sequencing-based analysis of microbiomes	15
Plant pattern recognition receptors: from evolutionary insight to engineering	15
Interplay between chromatin marks in development and disease	15
A vast potential genome editor toolbox	14
Tracking haplotypes to quantify genome erosion	14
The human genetic epidemiology of COVID-19	14
BANKSY: scalable cell typing and domain segmentation for spatial omics	14
Prime editing for precise and highly versatile genome manipulation	14
Current advances in primate genomics: novel approaches for understanding evolution and disease	14
The genetics of obesity: from discovery to biology	13
Tracking protein binding to cis-regulatory elements with PRINT	12
How the waxing and waning of a mutation determines HIV treatment success	11
DNA replication in cell fate reprogramming	11
Cryptic initiation drives transcriptional junk in ageing	10
Nuclear genome influences mitochondrial DNA	10

Genome-wide association testing beyond SNPs	10
Live long & prosper: evidence of evolutionary forces on lifespan	10
Plant pangenomes for crop improvement, biodiversity and evolution	9
Dissecting the genetics of ovarian ageing	9
Determining variant effects with pooled prime editing	9
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	9
High-resolution imaging of RNA and proteins in thick tissues using cycleHCR	9
Methods and applications of genome-wide profiling of DNA damage and rare mutations	9
Efficient computation reveals rare CRISPR–Cas systems	9
Deafness: from genetic architecture to gene therapy	8
Neighbourly modulation of transcript isoforms	8
Measuring the effects of regulatory variants in an endogenous context	8
Genetics of glycosylation in mammalian development and disease	8
Tandem repeat variation of human centromeres	8
DNA methylation-based predictors of health: applications and statistical considerations	7
The regulation and function of post-transcriptional RNA splicing	7
Spatial miRNomics: towards the integration of microRNAs in spatial biology	7
Chromatin loops facilitate co-regulation of paralogues	7
Gregor Mendel and the concepts of dominance and recessiveness	6
Exploring biodiversity through museomics	6
Gene regulatory network inference in the era of single-cell multi-omics	6
An uneasy truce between population health and the gene pools within our bodies	6
Viral protection from viruses	6
Opportunities and challenges of macrogenetic studies	6
Harnessing lateral gene transfer and endosymbiosis for adaptation	6
Dynamic alternative DNA structures in biology and disease	6
RNA barcoding: the catalyst for the single-cell revolution	5
Single-cell omics meets organoid cultures	5
Transcriptional coupling of long-distance genes	5
Connecting noncoding variants to human traits	5
Detecting pregnancy complications from blood	5
Foreseeing the principles of genome architecture	5
Publisher Correction: How germ granules promote germ cell fate	5
Beyond genetics for cancer evolution	5
An evolutionary continuum between non-coding and coding DNA	4
Systemic cell–cell communication in cancer	4
An evolving hypothesis in autoimmune disease genetics	4
Navigating the pitfalls of applying machine learning in genomics	4
Methodological opportunities in genomic data analysis to advance health equity	4
Pharmacogenomics: current status and future perspectives	4
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	4
Context-specific Polycomb mechanisms in development	4
The design and engineering of synthetic genomes	4
To the rescue by blocking cryptic splicing	4
Genetics of human telomere biology disorders	4
Alu sequences promote long-distance relationships	4
Not all co-repressors are equal	3
Tuning mutagenesis by functional outcome	3
The root cause of shoot-borne roots	3
Metabolic engineering of plant medicines	3
A body-wide view of somatic mutations	3
Sex differences of oestradiol-mediated gene expression	3
RNA splicing — a central layer of gene regulation	3
The biological and clinical significance of emerging SARS-CoV-2 variants	3
Engineering an oscillating gene circuit to delay cellular ageing	3
Identifying off-target effects of genome editing with Tracking-seq	3
Selection on structural variation in the amylase locus	3
Adapting systems biology to address the complexity of human disease in the single-cell era	3
Author Correction: The origin of human mutation in light of genomic data	3
A call to action to scale up research and clinical genomic data sharing	3
CROWN-seq reveals m6Am landscapes and transcription start site diversity	3
Charting the world’s microbiomes	3
Understanding human placentation through spatial multiomics	3
A TAD refined for gene regulation	3
Drug delivery systems for RNA therapeutics	3
Biomarker benchmarking	3
Variant calling and benchmarking in an era of complete human genome sequences	3
When cellular reprogramming meets AI: towards de novo cell design	3
Towards gene therapy for Tay-Sachs disease	2
DNA Typewriter	2
Revealing secrets of human genetic variation with population databases	2
Predictive evidence of the relevance of epigenetics to PTSD	2
Illuminating the human yolk sac through single-cell omics	2
Computational analysis of cancer genome sequencing data	2
Target-directed microRNA degradation in Drosophila	2
Sequencing to save the Kākāpō	2
Measuring biological age using omics data	2
Histone post-translational modifications — cause and consequence of genome function	2
Nuclear receptors — studying genes to understand hormones	2
The effects of loss of Y chromosome on male health	2
Fighting fibrosis with transient CAR T cells	2
Including diverse populations enhances the discovery of type 2 diabetes loci	2
Author Correction: Functional genomics data: privacy risk assessment and technological mitigation	2
Mapping vertebrate brain evolution	2
Human organs-on-chips for disease modelling, drug development and personalized medicine	2
Maverick — top gun of horizontal gene transfer	2
Sequencing and characterizing short tandem repeats in the human genome	2
SIMPLE-seq to decode DNA methylation dynamics in single cells	2
The genetics of human performance	2
The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus	2
The complex non-genetic inheritance of complex traits	2
Ethical governance for genomic data science in the cloud	2
Genetic prediction of multi-omic traits	2
DNA methylation in mammalian development and disease	2
Computational methods for analysing multiscale 3D genome organization	2