Nature Reviews Genetics

Article	Citations
Single-cell expression profiling has its roots in in situ techniques	1008
Explaining the male bias in cancers	922
The different faces of transcription factor sensitivity	742
The evolution of modifier genes	701
Disentangling population structure in marine species	545
The evolution of DNA sequencing with microfluidics	511
Weaponized genomics: potential threats to international and human security	488
Imprinted genes and the manipulation of parenting in mammals	413
Microorganisms as architects of a sustainable future	386
Gene regulatory networks: from correlative models to causal explanations	379
Harnessing deep learning for population genetic inference	366
Interrogating epigenetic mechanisms with chemically customized chromatin	318
Pleiotropy, epistasis and the genetic architecture of quantitative traits	302
Enhancing sustainable development through plant genetics	284
Unveiling the expanding protein universe of life	280
Rapid pathogen surveillance: field-ready sequencing solutions	278
The origin of animals and fungi	246
The evolutionary foundations of transcriptional regulation in animals	240
Cis-regulatory elements at cellular resolution	230
More than a decade of genetic research on the Denisovans	223
Changes in cell-cycle rate drive diverging cell fates	219
Long non-coding RNAs as orchestrators of dosage compensation	213
RNA polymerase II transcription compartments — from factories to condensates	209
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	206
Progress in toxicogenomics to protect human health	204

Best practices for single-cell analysis across modalities	196
Mapping dosage	192
Mini-colons unlock tumour development outside the body	188
Non-retroviral RNA viruses in eukaryotic genomes	186
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores	179
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	179
Annotating genomes at increased scale and resolution	174
Revealing gene function with statistical inference at single-cell resolution	168
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	166
Targeted genome-modification tools and their advanced applications in crop breeding	163
Intrinsically disordered regions as facilitators of the transcription factor target search	158
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	146
Layering epigenomic and transcriptomic space	145
Genomic landscape of cancer in racially and ethnically diverse populations	137
Epigenomes get personal	135
Predicting the effects of multigene perturbations	131
The hidden diversity of tumours	130
Swapping genes within and beyond our bodies	121
Mate choice through a genomic lens	120
Miller spreads and the power of observation	116
Cohesin and CTCF emerge as building blocks of 3D genome structure	113
Single cell–cell communication	109
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	109
CHIPping away at the genetic aetiology of clonal haematopoiesis	106
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	105
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	104
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	104
Redefining cellular reprogramming with advanced genomic technologies	99
Genomic newborn screening for rare diseases	96
Clinical use of polygenic risk scores: current status, barriers and future directions	93
The origin and evolution of Wnt signalling	92
Global genomic diversity for All of Us	92
Fitness effects of mutations throughout evolution	90
Social shifts in spiders	90
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	89
Targeting and engineering long non-coding RNAs for cancer therapy	88
High-throughput biochemistry in RNA sequence space: predicting structure and function	84
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	82
Why geneticists should care about male infertility	78
Recoding genomes with programmed ribosomal frameshifting	77
The diversification of methods for studying cell–cell interactions and communication	76
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	75
Effects of regulatory variants across pig tissues	75
A digital marker for coronary artery disease	73
Microbial genomics for antimicrobial resistance ecology and action	69
A whole-genome shotgun approach to human reference genome sequencing	69
Exon junction complex modulates m6A distribution	66
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	64
Mosaic variegated aneuploidy in development, ageing and cancer	63
Genomic surveillance for antimicrobial resistance — a One Health perspective	61

Navigating the pitfalls of mapping DNA and RNA modifications	61
Sex-specific morphs: the genetics and evolution of intra-sexual variation	60
Chromosomal instability as a driver of cancer progression	59
The expanding diagnostic toolbox for rare genetic diseases	59
Genomics for monitoring and understanding species responses to global climate change	56
Divergence and conservation of the meiotic recombination machinery	55
TimeVault: a synthetic time capsule for transcriptome storage	54
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	54
Programmable DNA rearrangements using bridge RNAs	53
Genetics of circadian rhythms and sleep in human health and disease	53
A developmental exit from totipotency	52
SCENT defines non-coding disease mechanisms using single-cell multi-omics	52
microRNAs as systemic regulators of ageing	49
Harnessing evolution to infer protein networks	49
How ancient genes form animal body plans	48
The evolutionary tale of lactase persistence in humans	46
Prioritizing the detection of rare pathogenic variants in population screening	46
Functional synonymous mutations and their evolutionary consequences	46
Challenges and best practices in omics benchmarking	44
Context-specific functions of chromatin remodellers in development and disease	43
Tools and tactics for studying alternative splicing	42
Translating genomic advances into biodiversity conservation	40
Biobanking with genetics shapes precision medicine and global health	39
Integrating ELSI study teams in paediatric genomic research efforts	39
New insights into genome folding by loop extrusion from inducible degron technologies	39
Global cooperation for a global pandemic	39
Reading cell division histories from the methylome	38
tRNA dysregulation and disease	38
Towards improved fine-mapping of candidate causal variants	37
The lives of cells, recorded	37
Packaging and delivery of genome-editing tools	36
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	35
Nascent transcription quantification with scFLUENT-seq	34
Author Correction: Transposable elements: McClintock’s legacy revisited	34
Cell-type deconvolution methods for spatial transcriptomics	32
Context-specific regulatory variants in precision medicine and agriculture	32
The nexus between RNA-binding proteins and their effectors	32
Multifunctional histone variants in genome function	32
The FinnGen study: disease insights from a ‘bottlenecked’ population	32
Predicting gene expression from DNA sequence using deep learning models	31
Methods and applications for single-cell and spatial multi-omics	30
In vivo editing of blood stem cells	29
Mary Lyon and the birth of X-inactivation research	28
Corrupted USB1 fails to process microRNAs required for blood development	27
Stem cell-derived organoid models: defying the Hayflick limit	27
Ancient migration and the modern genome	27
The continuum of transcription factor affinities	25
Biological roles of adenine methylation in RNA	24
The regulatory landscape of chromatin accessibility	24
The genetic basis of human height	24
Spatial architecture of development and disease	23
Monitoring biological effects of somatic cell genome editing	23
De novo genes: from non-genic to genic	23
The gene variant that helped put Latinxs in the 1000 genomes project	22
Single-cell genomics meets human genetics	22
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01	22
A codon-resolved view of subcellular translation with LOCL-TL	22
Genetic variation across and within individuals	21
Endogenous retroviruses: unveiling new targets for cancer immunotherapy	21
The human genetic epidemiology of COVID-19	19
Making sense of the polygenicity of complex traits	18
Tandem repeats in the long-read sequencing era	17
Cytoplasmic mRNA decay and quality control machineries in eukaryotes	17
Forensic genetics in the omics era	17
Prime editing for precise and highly versatile genome manipulation	17
Author Correction: Forensic genetics in the omics era	17
Plant pattern recognition receptors: from evolutionary insight to engineering	17
Sequencing-based analysis of microbiomes	16
Current advances in primate genomics: novel approaches for understanding evolution and disease	15
BANKSY: scalable cell typing and domain segmentation for spatial omics	15
How the waxing and waning of a mutation determines HIV treatment success	14
Ancestral diversity in complex disease genetics: from discovery to translation	14
From clonality to complexity: a journey through microbial ecology and evolution	14
Tracking protein binding to cis-regulatory elements with PRINT	14
Determining variant effects with pooled prime editing	14
Cryptic initiation drives transcriptional junk in ageing	13
Plant pangenomes for crop improvement, biodiversity and evolution	13
Methods and applications of genome-wide profiling of DNA damage and rare mutations	13
Live long & prosper: evidence of evolutionary forces on lifespan	13
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	13

Prompt-based bioinformatics: a new interface for multi-omics analysis	12
Dissecting pleiotropy to gain mechanistic insights into human disease	11
Nuclear genome influences mitochondrial DNA	11
Prospects for personalized cancer treatment in the era of single-cell sequencing	11
Genome-wide association testing beyond SNPs	11
Genetics of glycosylation in mammalian development and disease	11
High-resolution imaging of RNA and proteins in thick tissues using cycleHCR	11
Measuring the effects of regulatory variants in an endogenous context	11
Tandem repeat variation of human centromeres	11
Efficient computation reveals rare CRISPR–Cas systems	10
How classical genetics uncovered key determinants of TE silencing	10
Spatial miRNomics: towards the integration of microRNAs in spatial biology	10
Deafness: from genetic architecture to gene therapy	9
Gregor Mendel and the concepts of dominance and recessiveness	8
Chromatin loops facilitate co-regulation of paralogues	8
From models to molecules: self-organized and instructed modes of developmental patterning	7
Exploring biodiversity through museomics	7
Genetic influences on haematopoiesis	7
Harnessing lateral gene transfer and endosymbiosis for adaptation	7
Harnessing artificial intelligence to advance CRISPR-based genome editing technologies	7
An uneasy truce between population health and the gene pools within our bodies	7
The regulation and function of post-transcriptional RNA splicing	7
The genetic foundations of convergent traits	7
RNA barcoding: the catalyst for the single-cell revolution	6
Dynamic alternative DNA structures in biology and disease	6
Publisher Correction: How germ granules promote germ cell fate	6
Transcriptional coupling of long-distance genes	6
Gene regulatory network inference in the era of single-cell multi-omics	6
An evolutionary continuum between non-coding and coding DNA	6
Viral protection from viruses	6
Connecting noncoding variants to human traits	5
Single-cell omics meets organoid cultures	5
Author Correction: Evolution and regulation of animal sex chromosomes	5
The design and engineering of synthetic genomes	5
Pharmacogenomics: current status and future perspectives	5
Emergence and evolution of protein-coding de novo genes	5
More than meets the eye(spot): evolution through co-option of developmental programmes	5
Methodological opportunities in genomic data analysis to advance health equity	5
Alu sequences promote long-distance relationships	5
Systemic cell–cell communication in cancer	5
To the rescue by blocking cryptic splicing	5
Understanding human placentation through spatial multiomics	4
Not all co-repressors are equal	4
Context-specific Polycomb mechanisms in development	4
When cellular reprogramming meets AI: towards de novo cell design	4
Metabolic engineering of plant medicines	4
Selection on structural variation in the amylase locus	4
Genetics of human telomere biology disorders	4
Charting the world’s microbiomes	4
Identifying off-target effects of genome editing with Tracking-seq	4
Adapting systems biology to address the complexity of human disease in the single-cell era	4
CROWN-seq reveals m6Am landscapes and transcription start site diversity	4
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	4
Engineering an oscillating gene circuit to delay cellular ageing	4
Sex differences of oestradiol-mediated gene expression	4
A TAD refined for gene regulation	4
A call to action to scale up research and clinical genomic data sharing	4
Epistasis and co-adaptation in bacterial genome evolution	3
Collaborating at the nexus of genomics, humanities, social science and stakeholders	3
Unlocking the potential of pedigree genomics via precision governance	3
Predictive evidence of the relevance of epigenetics to PTSD	3
Regulatory genomics at biobank scales	3
Sequencing to save the Kākāpō	3
Is enhancer-driven gene regulation all wrapped up?	3
The effects of loss of Y chromosome on male health	3
DNA Typewriter	3
RNA splicing — a central layer of gene regulation	3
Variant calling and benchmarking in an era of complete human genome sequences	3
SIMPLE-seq to decode DNA methylation dynamics in single cells	3
The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus	3
Illuminating the human yolk sac through single-cell omics	3
Biomarker benchmarking	3
A crossroads in the timeline of human evolution	3
Nuclear receptors — studying genes to understand hormones	3
Tracing the evolution of sequencing into the era of genomic medicine	3
Revealing secrets of human genetic variation with population databases	3
The evolution of Mycobacterium tuberculosis as humans migrated out of Africa	3
Sequencing and characterizing short tandem repeats in the human genome	3
Decoding protein–RNA interactions using CLIP-based methodologies	2
Decoding human genetic variation using a synthetic paradigm	2
Average nucleotide identity — the backbone of modern ecological genomics	2
Non-coding RNAs in disease: from mechanisms to therapeutics	2
High-throughput identification of aptamer–target pairs with SPARK-seq	2
Stochastic transitions as a major source of cancer heterogeneity	2
From Mendel’s laws to non-Mendelian inheritance	2
Linking disease-associated genetic variants to cell types and processes	2
Locking in a synthetic genetic code	2
Mapping trait-associated cells with spatial transcriptomics	2
A TRIP to understand gene regulation	2
A focus on single-cell omics	2
X-linked competition — implications for human development and disease	2
A diverse and inclusive human pangenome	2
Thoughts on a legacy	2
Regulatory genome annotation	2
Maverick — top gun of horizontal gene transfer	2