Nature Reviews Genetics

Article	Citations
The different faces of transcription factor sensitivity	1290
High-resolution 3D genome characterization	896
Explaining the male bias in cancers	803
Single-cell expression profiling has its roots in in situ techniques	774
Tightening the (neural) net for protein structure prediction	721
Disentangling population structure in marine species	640
Enhancing sustainable development through plant genetics	604
The evolution of DNA sequencing with microfluidics	599
SCOPE-ing out eukaryotic 6mA	514
Weaponized genomics: potential threats to international and human security	387
The evolution of modifier genes	349
Genomic prediction of neoantigens: immunogenomics before NGS	348
Getting organized with non-coding RNAs	332
Mining genomes to illuminate the specialized chemistry of life	313
Interrogating epigenetic mechanisms with chemically customized chromatin	304
Imprinted genes and the manipulation of parenting in mammals	284
Means, mechanisms and consequences of adenine methylation in DNA	270
Pleiotropy, epistasis and the genetic architecture of quantitative traits	254
Harnessing deep learning for population genetic inference	236
Genomic insights into conifer evolution	208
Unveiling the expanding protein universe of life	199
Rapid pathogen surveillance: field-ready sequencing solutions	196
Progress in toxicogenomics to protect human health	193
More than a decade of genetic research on the Denisovans	191
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	183

Testing at scale during the COVID-19 pandemic	181
Changes in cell-cycle rate drive diverging cell fates	177
The origin of animals and fungi	176
Testing the super-enhancer concept	168
Best practices for single-cell analysis across modalities	167
Abiotic stress responses in plants	163
CRISPR editing within microbial communities	158
Shared genetic components of multimorbidity	149
Layering epigenomic and transcriptomic space	143
Intrinsically disordered regions as facilitators of the transcription factor target search	139
Revealing gene function with statistical inference at single-cell resolution	138
Genomic landscape of cancer in racially and ethnically diverse populations	134
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	134
Mapping dosage	131
Aneuploidy in the driving seat	128
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	128
Mini-colons unlock tumour development outside the body	125
Genetics of substance use disorders in the era of big data	124
Single cell–cell communication	118
Targeted genome-modification tools and their advanced applications in crop breeding	118
Predicting the effects of multigene perturbations	117
Epigenomes get personal	116
CHIPping away at the genetic aetiology of clonal haematopoiesis	113
The hidden diversity of tumours	113
Miller spreads and the power of observation	110
Swapping genes within and beyond our bodies	109
Retrotransposons: still mobile in humans	108
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	102
Fine-mapping causal variants — why finding ‘the one’ can be futile	101
Mate choice through a genomic lens	101
Cohesin and CTCF emerge as building blocks of 3D genome structure	101
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	99
The origin and evolution of Wnt signalling	97
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	97
Social shifts in spiders	95
Genomic newborn screening for rare diseases	95
The final pieces of the human genome	89
Why geneticists should care about male infertility	86
Global genomic diversity for All of Us	84
Fitness effects of mutations throughout evolution	84
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	82
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	82
Targeting and engineering long non-coding RNAs for cancer therapy	79
The potential of mitochondrial genome engineering	75
High-throughput biochemistry in RNA sequence space: predicting structure and function	73
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	72
The diversification of methods for studying cell–cell interactions and communication	72
Exon junction complex modulates m6A distribution	72
Effects of regulatory variants across pig tissues	72
A digital marker for coronary artery disease	69

A whole-genome shotgun approach to human reference genome sequencing	66
Mosaic variegated aneuploidy in development, ageing and cancer	65
Sex-specific morphs: the genetics and evolution of intra-sexual variation	65
Divergence and conservation of the meiotic recombination machinery	64
Navigating the pitfalls of mapping DNA and RNA modifications	64
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	64
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	61
Genomics for monitoring and understanding species responses to global climate change	60
Chromosomal instability as a driver of cancer progression	60
The expanding diagnostic toolbox for rare genetic diseases	60
Genetics of circadian rhythms and sleep in human health and disease	59
Genomic surveillance for antimicrobial resistance — a One Health perspective	58
Laterally mobile chromosomes	57
Using cell-free DNA to infer gene expression	56
Programmable DNA rearrangements using bridge RNAs	56
How ancient genes form animal body plans	55
SCENT defines non-coding disease mechanisms using single-cell multi-omics	54
Prioritizing the detection of rare pathogenic variants in population screening	53
The evolutionary tale of lactase persistence in humans	53
microRNAs as systemic regulators of ageing	52
Widespread occurrence of circular RNA in eukaryotes	49
A developmental exit from totipotency	49
New insights into genome folding by loop extrusion from inducible degron technologies	46
Challenges and best practices in omics benchmarking	44
Translating genomic advances into biodiversity conservation	44
Context-specific functions of chromatin remodellers in development and disease	43
Theranostic cells: emerging clinical applications of synthetic biology	42
Biobanking with genetics shapes precision medicine and global health	41
Author Correction: Transposable elements: McClintock’s legacy revisited	38
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	36
The lives of cells, recorded	36
Global cooperation for a global pandemic	35
Publisher Correction: Germline risk of clonal haematopoiesis	35
Context-specific regulatory variants in precision medicine and agriculture	35
Multifunctional histone variants in genome function	34
Integrating ELSI study teams in paediatric genomic research efforts	34
The FinnGen study: disease insights from a ‘bottlenecked’ population	34
Packaging and delivery of genome-editing tools	33
tRNA dysregulation and disease	31
Methods and applications for single-cell and spatial multi-omics	31
The nexus between RNA-binding proteins and their effectors	31
In vivo editing of blood stem cells	30
Homozygosity mapping: a game-changer for autosomal recessive diseases	29
De novo genes: from non-genic to genic	29
The continuum of transcription factor affinities	29
Publisher Correction: Sociotechnical safeguards for genomic data privacy	28
Corrupted USB1 fails to process microRNAs required for blood development	28
Mary Lyon and the birth of X-inactivation research	28
The regulatory landscape of chromatin accessibility	26
First glimpse of enhancers in gene regulation	26
Stem cell-derived organoid models: defying the Hayflick limit	26
The genetic basis of human height	26
Ancient migration and the modern genome	26
Single-cell genomics meets human genetics	24
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	23
Biological roles of adenine methylation in RNA	21
EpiDamID, a new single-cell multi-omics tool	20
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01	20
Impact of genetic ancestry on viral infection response	20
Tandem repeats in the long-read sequencing era	19
The gene variant that helped put Latinxs in the 1000 genomes project	19
The human genetic epidemiology of COVID-19	19
Endogenous retroviruses: unveiling new targets for cancer immunotherapy	18
Publisher Correction: The relationship between genome structure and function	18
Plant pattern recognition receptors: from evolutionary insight to engineering	18
Genetic variation across and within individuals	17
Sequencing-based analysis of microbiomes	16
Cytoplasmic mRNA decay and quality control machineries in eukaryotes	16
Interplay between chromatin marks in development and disease	15
A vast potential genome editor toolbox	15
Prime editing for precise and highly versatile genome manipulation	15
Current advances in primate genomics: novel approaches for understanding evolution and disease	14
Tracking haplotypes to quantify genome erosion	14
Ribosomal protein genes as sensors of aneuploidy	14
BANKSY: scalable cell typing and domain segmentation for spatial omics	14
Cryptic initiation drives transcriptional junk in ageing	13
Tracking protein binding to cis-regulatory elements with PRINT	13
The genetics of obesity: from discovery to biology	13
DNA replication in cell fate reprogramming	12
How the waxing and waning of a mutation determines HIV treatment success	11

Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	11
Nuclear genome influences mitochondrial DNA	11
Genome-wide association testing beyond SNPs	11
Live long & prosper: evidence of evolutionary forces on lifespan	11
Methods and applications of genome-wide profiling of DNA damage and rare mutations	10
Plant pangenomes for crop improvement, biodiversity and evolution	9
Tandem repeat variation of human centromeres	8
Efficient computation reveals rare CRISPR–Cas systems	8
Neighbourly modulation of transcript isoforms	8
Spatial miRNomics: towards the integration of microRNAs in spatial biology	8
Dissecting the genetics of ovarian ageing	8
Exploring biodiversity through museomics	7
Opportunities and challenges of macrogenetic studies	7
Genetics of glycosylation in mammalian development and disease	7
Gregor Mendel and the concepts of dominance and recessiveness	7
The regulation and function of post-transcriptional RNA splicing	7
DNA methylation-based predictors of health: applications and statistical considerations	7
Chromatin loops facilitate co-regulation of paralogues	7
Deafness: from genetic architecture to gene therapy	7
Viral protection from viruses	6
Detecting pregnancy complications from blood	6
Single-cell omics meets organoid cultures	6
Transcriptional coupling of long-distance genes	6
Beyond genetics for cancer evolution	6
Gene regulatory network inference in the era of single-cell multi-omics	6
Dynamic alternative DNA structures in biology and disease	6
Foreseeing the principles of genome architecture	5
Pharmacogenomics: current status and future perspectives	5
Connecting noncoding variants to human traits	5
To the rescue by blocking cryptic splicing	5
The design and engineering of synthetic genomes	5
Publisher Correction: How germ granules promote germ cell fate	5
Chromatin context affects DNA repair pathway	5
RNA barcoding: the catalyst for the single-cell revolution	5
Alu sequences promote long-distance relationships	4
Drug delivery systems for RNA therapeutics	4
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	4
Genetics of human telomere biology disorders	4
Fetal growth: a family affair	4
An evolving hypothesis in autoimmune disease genetics	4
Navigating the pitfalls of applying machine learning in genomics	4
Context-specific Polycomb mechanisms in development	4
The biological and clinical significance of emerging SARS-CoV-2 variants	4
Systemic cell–cell communication in cancer	4
Not all co-repressors are equal	3
Understanding human placentation through spatial multiomics	3
Selection on structural variation in the amylase locus	3
Germline risk of clonal haematopoiesis	3
The root cause of shoot-borne roots	3
A TAD refined for gene regulation	3
Engineering an oscillating gene circuit to delay cellular ageing	3
Tuning mutagenesis by functional outcome	3
Mitochondrial DNA variants in genomic data: diagnostic uplifts and predictive implications	3
Metabolic engineering of plant medicines	3
Charting the world’s microbiomes	3
Sex differences of oestradiol-mediated gene expression	3
Identifying off-target effects of genome editing with Tracking-seq	3
Adapting systems biology to address the complexity of human disease in the single-cell era	3
A call to action to scale up research and clinical genomic data sharing	3
Ethical governance for genomic data science in the cloud	2
Genetic prediction of multi-omic traits	2
Fighting fibrosis with transient CAR T cells	2
The complex non-genetic inheritance of complex traits	2
DNA methylation in mammalian development and disease	2
Sequencing and characterizing short tandem repeats in the human genome	2
The effects of loss of Y chromosome on male health	2
Author Correction: The origin of human mutation in light of genomic data	2
A body-wide view of somatic mutations	2
Histone post-translational modifications — cause and consequence of genome function	2
Measuring biological age using omics data	2
Target-directed microRNA degradation in Drosophila	2
Human organs-on-chips for disease modelling, drug development and personalized medicine	2
Base editing takes a shot at disease in non-human primates	2
Sequencing to save the Kākāpō	2
The origin of human mutation in light of genomic data	2
Predictive evidence of the relevance of epigenetics to PTSD	2
DNA Typewriter	2
Oncogenesis by phase separation	2
Nuclear receptors — studying genes to understand hormones	2
Maverick — top gun of horizontal gene transfer	2
Mapping vertebrate brain evolution	2
Computational methods for analysing multiscale 3D genome organization	2
Including diverse populations enhances the discovery of type 2 diabetes loci	2
Illuminating the human yolk sac through single-cell omics	2
The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus	2
The genetics of human performance	2
SIMPLE-seq to decode DNA methylation dynamics in single cells	2
Biomarker benchmarking	2
Variant calling and benchmarking in an era of complete human genome sequences	2
Towards gene therapy for Tay-Sachs disease	2