Nature Reviews Genetics

Article	Citations
Abiotic stress responses in plants	962
The biological and clinical significance of emerging SARS-CoV-2 variants	827
Deciphering cell–cell interactions and communication from gene expression	714
Drug delivery systems for RNA therapeutics	588
Human organs-on-chips for disease modelling, drug development and personalized medicine	560
The genetics of obesity: from discovery to biology	539
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics	517
The epitranscriptome beyond m6A	411
RNA-binding proteins in human genetic disease	410
Histone post-translational modifications — cause and consequence of genome function	396
Methods and applications for single-cell and spatial multi-omics	354
Best practices for single-cell analysis across modalities	289
Testing at scale during the COVID-19 pandemic	280
Molecular mechanisms of transgenerational epigenetic inheritance	251
Prime editing for precise and highly versatile genome manipulation	211
Autophagy genes in biology and disease	197
The emerging landscape of spatial profiling technologies	195
Towards population-scale long-read sequencing	191
The relationship between genome structure and function	189
The epigenetic basis of cellular heterogeneity	184
Measuring biological age using omics data	182
Alternative splicing as a source of phenotypic diversity	178
Molecular and evolutionary processes generating variation in gene expression	172
Gene therapy using haematopoietic stem and progenitor cells	170
Reprogramming the genetic code	166

Transposable elements shape the evolution of mammalian development	164
Enhancer redundancy in development and disease	163
microRNAs in action: biogenesis, function and regulation	154
The influence of evolutionary history on human health and disease	152
Advancing the use of genome-wide association studies for drug repurposing	150
Obtaining genetics insights from deep learning via explainable artificial intelligence	144
Mining genomes to illuminate the specialized chemistry of life	142
Navigating the pitfalls of applying machine learning in genomics	142
A new era in functional genomics screens	134
Biological roles of adenine methylation in RNA	131
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination	126
Genetic load: genomic estimates and applications in non-model animals	122
Host genetics and infectious disease: new tools, insights and translational opportunities	121
Gene drives gaining speed	117
Non-coding RNAs in disease: from mechanisms to therapeutics	114
Making sense of the ageing methylome	113
Primary cilia as dynamic and diverse signalling hubs in development and disease	109
DNA methylation-based predictors of health: applications and statistical considerations	107
Gene regulatory network inference in the era of single-cell multi-omics	104
Clinical cancer genomic profiling	96
Characterizing cis-regulatory elements using single-cell epigenomics	96
Epigenome plasticity in plants	93
Single-cell atlases: shared and tissue-specific cell types across human organs	92
Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic	89
Mechanical regulation of chromatin and transcription	89
Polygenic scores in biomedical research	88
Generation of extracellular morphogen gradients: the case for diffusion	87
Advances and opportunities in malaria population genomics	87
Pharmacogenomics: current status and future perspectives	86
Temporal modelling using single-cell transcriptomics	86
The human genetic epidemiology of COVID-19	84
Probing the dynamic RNA structurome and its functions	83
African genetic diversity and adaptation inform a precision medicine agenda	83
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects	82
Genetic innovations in animal–microbe symbioses	81
Parental nucleosome segregation and the inheritance of cellular identity	81
The roles of microRNAs in mouse development	81
Interplay between chromatin marks in development and disease	79
tRNA dysregulation and disease	79
Genetic engineering of T cells for immunotherapy	79
The spatial organization of transcriptional control	77
Dynamic alternative DNA structures in biology and disease	77
Genetics of circadian rhythms and sleep in human health and disease	77
Genetics of human telomere biology disorders	76
Organization and expression of the mammalian mitochondrial genome	74
Genetics of substance use disorders in the era of big data	73
Spatial biology of cancer evolution	72
Molecular mechanisms of environmental exposures and human disease	71
Statistical mechanics meets single-cell biology	71
The potential of mitochondrial genome engineering	70

Overlapping genes in natural and engineered genomes	67
Generating specificity in genome regulation through transcription factor sensitivity to chromatin	66
Cross-species RNA-seq for deciphering host–microbe interactions	64
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	64
Principles and methods for transferring polygenic risk scores across global populations	63
Means, mechanisms and consequences of adenine methylation in DNA	61
Testing the super-enhancer concept	61
Opportunities and challenges of macrogenetic studies	60
Theranostic cells: emerging clinical applications of synthetic biology	60
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	58
Sociotechnical safeguards for genomic data privacy	56
Germline risk of clonal haematopoiesis	54
Engineering synthetic RNA devices for cell control	53
Origins of human disease: the chrono-epigenetic perspective	53
Incongruence in the phylogenomics era	53
Context-specific Polycomb mechanisms in development	52
Disentangling host–microbiota complexity through hologenomics	51
Computational analysis of cancer genome sequencing data	51
RNA modifications in physiology and disease: towards clinical applications	50
Extrachromosomal DNA amplifications in cancer	49
Examining the evidence for extracellular RNA function in mammals	49
Decoding disease: from genomes to networks to phenotypes	49
Genomic newborn screening for rare diseases	48
HIV-1 and human genetic variation	47
Variant calling and benchmarking in an era of complete human genome sequences	47
Towards improved genetic diagnosis of human differences of sex development	45
New insights into genome folding by loop extrusion from inducible degron technologies	42
Engineering 3D genome organization	41
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	40
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	39
Mutation–selection balance and compensatory mechanisms in tumour evolution	39
Single-cell genomics meets human genetics	38
The origin of human mutation in light of genomic data	37
Soma-to-germline RNA communication	37
Deafness: from genetic architecture to gene therapy	36
Genomic surveillance for antimicrobial resistance — a One Health perspective	36
Transposable elements in mammalian chromatin organization	36
Microbiome epidemiology and association studies in human health	33
The nexus between RNA-binding proteins and their effectors	32
Sex-specific morphs: the genetics and evolution of intra-sexual variation	29
Purple Tomatoes, Black Rice and Food Security	28
Mendelian inheritance revisited: dominance and recessiveness in medical genetics	27
Genetics of human brain development	27
The genetics of human performance	27
Towards a physical understanding of developmental patterning	27
Transitioning single-cell genomics into the clinic	26
Regulation of the RNA polymerase II pre-initiation complex by its associated coactivators	25
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	25
Perfect and imperfect views of ultraconserved sequences	22
Beyond assembly: the increasing flexibility of single-molecule sequencing technology	22
Functional genomics data: privacy risk assessment and technological mitigation	22
From systems to structure — using genetic data to model protein structures	21
Genome assembly in the telomere-to-telomere era	21
Navigating the pitfalls of mapping DNA and RNA modifications	20
Current advances in primate genomics: novel approaches for understanding evolution and disease	20
Repetitive DNA: genomic dark matter matters	20
Genetic determinism, essentialism and reductionism: semantic clarity for contested science	19
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	19
The diversification of methods for studying cell–cell interactions and communication	19
Genomics for monitoring and understanding species responses to global climate change	19
Interpreting non-coding disease-associated human variants using single-cell epigenomics	18
Addressing health disparities in cancer with genomics	15
Sequencing and characterizing short tandem repeats in the human genome	14
Widespread occurrence of circular RNA in eukaryotes	14
Biparental inheritance of mitochondrial DNA revisited	14
Computational methods for analysing multiscale 3D genome organization	14
Pioneer factors — key regulators of chromatin and gene expression	14
Navigating bottlenecks and trade-offs in genomic data analysis	13
Opportunities and challenges for the use of common controls in sequencing studies	13
Divergence and conservation of the meiotic recombination machinery	13
Prioritizing the detection of rare pathogenic variants in population screening	13
Targeting and engineering long non-coding RNAs for cancer therapy	12
Fine-mapping causal variants — why finding ‘the one’ can be futile	11
High-throughput biochemistry in RNA sequence space: predicting structure and function	10
The mutation rate as an evolving trait	10
The TOPMed genomic resource for human health	10
Shaping faces: genetic and epigenetic control of craniofacial morphogenesis	9
Steering and controlling evolution — from bioengineering to fighting pathogens	9
Context-specific functions of chromatin remodellers in development and disease	9
Horizontal gene transfer in eukaryotes: aligning theory with data	8

More than a decade of genetic research on the Denisovans	8
Plant pangenomes for crop improvement, biodiversity and evolution	8
Real-time single-molecule imaging of transcriptional regulatory networks in living cells	8
Translating genomic advances into biodiversity conservation	8
The power of large-scale exome sequencing	8
SHARE-seq reveals chromatin potential	8
Harnessing deep learning for population genetic inference	8
Gregor Mendel and the concepts of dominance and recessiveness	7
The transition from genomics to phenomics in personalized population health	7
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	7
The origin and evolution of Wnt signalling	7
The magic and meaning of Mendel’s miracle	7
The expanding diagnostic toolbox for rare genetic diseases	7
Targeted genome-modification tools and their advanced applications in crop breeding	7
Sequencing-based analysis of microbiomes	6
Selection on synonymous sites: the unwanted transcript hypothesis	6
Natural antisense transcripts as versatile regulators of gene expression	6
Getting organized with non-coding RNAs	6
Interrogating epigenetic mechanisms with chemically customized chromatin	6
Inborn errors of immunity: an expanding universe of disease and genetic architecture	5
Sequence composition changes in short tandem repeats: heterogeneity, detection, mechanisms and clinical implications	5
CRISPR–Cas13 targets circRNAs	5
Challenges and best practices in omics benchmarking	5
Imprinted genes and the manipulation of parenting in mammals	5
Genomic outbreak surveillance in resource-poor settings	5
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	5
Implications of mitochondrial DNA mutations in human induced pluripotent stem cells	5
Pleiotropy, epistasis and the genetic architecture of quantitative traits	5
Genomic prediction of neoantigens: immunogenomics before NGS	5
Quantifying gene duplication	5
Gene–environment interactions in human health	5
Genome-scale single-cell CRISPR screens	4
Detecting pregnancy complications from blood	4
The FinnGen study: disease insights from a ‘bottlenecked’ population	4
Publisher Correction: The relationship between genome structure and function	4
Rethinking nomenclature for interspecies cell fusions	4
Mitochondrial DNA variants in genomic data: diagnostic uplifts and predictive implications	4
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	4
Predicting variant pathogenicity with AlphaMissense	4
Reconciliation between high yield and disease resistance	3
Mate choice through a genomic lens	3
From Mendel to a Mendelian disorder: towards a cure for sickle cell disease	3
From LD-based mapping to GWAS	3
Reverting to old theories of ageing with new evidence for the role of somatic mutations	3
Traversing industry and academia in biomedicine: the best of both worlds?	3
A focus on single-cell omics	3
Publisher Correction: Sociotechnical safeguards for genomic data privacy	3
Homozygosity mapping: a game-changer for autosomal recessive diseases	3
Transposable elements: McClintock’s legacy revisited	3
Host genetics of coronavirus infection	3
Genetics of chronic respiratory disease	3
Nuclear mRNA decay: regulatory networks that control gene expression	3
Capturing transposases for new proteins	3
Pan-cancer atlas of intratumour heterogeneity	3
Tandem repeat variation of human centromeres	3
Dissecting the genetics of ovarian ageing	2
How Hi-C ignited the era of 3D genome biology	2
DNA Typewriter	2
Exon junction complex modulates m6A distribution	2
The final pieces of the human genome	2
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01	2
Stem cell-derived organoid models: defying the Hayflick limit	2
New cuts for CRISPR effectors	2
Aneuploidy in the driving seat	2
Genomic insights into conifer evolution	2
Publisher Correction: Mutation–selection balance and compensatory mechanisms in tumour evolution	2
Chromosomal instability as a driver of cancer progression	2
A body-wide view of somatic mutations	2
Same genomes, but different	2
The emerging role of tandem repeats in complex traits	2
Genetic variation across and within individuals	2
Mary Lyon and the birth of X-inactivation research	2
Unequal global implementation of genomic newborn screening	2
Layering epigenomic and transcriptomic space	2
Genetics of glycosylation in mammalian development and disease	2
microRNAs as systemic regulators of ageing	2
In vivo RNA base editing with circular RNAs	2
Complex targeted sequencing in real time	2
A TAD refined for gene regulation	2
Human embryonic genetic mosaicism and its effects on development and disease	2
Mitochondrial DNA copy number and disease	2
Stochastic transitions as a major source of cancer heterogeneity	2
The chromosome hoarding syndrome of (some) ferns and lycophytes	2
CRISPR editing within microbial communities	2
Base editing takes a shot at disease in non-human primates	2
DNA packaging by molecular motors: from bacteriophage to human chromosomes	1
Weaponized genomics: potential threats to international and human security	1
Enhancing sustainable development through plant genetics	1
Disentangling population structure in marine species	1
Packaging and delivery of genome-editing tools	1
The puzzling guppy Y chromosome	1
Giant genomes of lungfish	1
Chromatin loops stack up	1
Single-cell expression profiling has its roots in in situ techniques	1
Human cell-lineage imbalances	1