OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Reports is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
METTL3 protects METTL14 from STUB1 ‐mediated degradation to maintai	205
LGBTIQ+N	148
Dynamin‐like proteins mediate extracellular vesicle secretion in Mycobacterium tuberculosis	146
Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair	146
The Golgi microtubules regulate single cell durotaxis	140
The mission to ensure continued funding for excellent basic research	135
Through an ecological lens	125
Global and precise identification of functional miRNA targets in mESCs by integrative analysis	121
Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus	119
SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ / BU	115
Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation	115
SCF ^FBXW7 regulates G2‐M progression thro	97
UBAP2L ‐dependent coupling of PLK1 localization and stability during mitosis	88
Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice	77
Enhancing Spns2/S1P in macrophages alleviates hyperinflammation and prevents immunosuppression in sepsis	76
E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of M	75
The post‐translational regulation of transcription factor EB ( TFEB ) in health and disease	69
Functional skewing of TRIM21‐SIRT5 interplay dictates IL ‐1β production in	66
CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection	64
The transcriptional regulator Sin3A balances IL‐17A and Foxp3 expression in primary	63
Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis	60
Striking the right balance between youth and experience	59
Animals do count	55
Noncanonical Wnt signaling promotes colon tumor growth, chemoresistance and tumor fibroblast activation	54
Tissue‐like environments shape functional interactions of HIV ‐1 with immature dendritic cells	54

Zika virus alters centrosome organization to suppress the innate immune response	53
Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network	53
Sequestration of LINE ‐1 in cytosolic aggregates by MOV10 restricts retrotransposition	51
Energetic landscape of polycystin channel gating	50
The DEAD box RNA helicase DDX42 is an intrinsic	47
Scalable RT‐LAMP‐based SARS‐CoV‐2 testing for infection surveillance with applications in pandemic preparedness	47
Somatosensory neurons express specific sets of lincRNAs , and lincRNA CLAP promotes itch sensation	47
Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo	46
Resting natural killer cell homeostasis relies on tryptophan/ NAD ⁺ metabolism and HIF	46
A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength	46
PRMT5 links lipid metabolism to contractile function of skeletal muscles	45
SPTing across condensates: SEC‐mediated translocation of SPT complex from pausing condensates to elongation condensates	44
Evolutionary remodelling of N‐terminal domain loops fine‐tunes SARS‐CoV ‐2 spike	43
IL ‐21 has a critical role in establishing germinal centers by amplifying early B cell proliferation	43
Morphofunctional changes at the active zone during synaptic vesicle exocytosis	43
Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster	43
pH regulates hematopoietic stem cell potential via polyamines	43
Introducing quality measures in an academic research consortium	42
The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis	42
The regulation of human blastoid research	42
Vitamin D receptor enhances NLRC4 inflammasome activation by promoting NAIPs–NLRC4 association	41
The GCN2 / eIF2αK stress kinase regulates PP1 t	41
DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres	40
Bipolar‐associated miR ‐499‐5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2	40
A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation	39
FOXM1 network in association with TREM1 suppression regulates NET f	39
STAT5b is a key effector of NRG ‐1/ ERBB4 ‐mediated myocardial grow	39
Malaria parasites release vesicle subpopulations with signatures of different destinations	38
Specific N ‐glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning	38
GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1	38
Autophagy orchestrates the crosstalk between cells and organs	37
BTNL2 promotes colitis‐associated tumorigenesis in mice by regulating IL ‐22 production	37
ER ‐phagy: selective autophagy of the endoplasmic reticulum	36
Tick‐borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2	36
Single cell clonal analysis identifies an AID ‐dependent pathway of plasma cell differentiation	36
Ovol1/2 loss‐induced epidermal defects elicit skin immune activation and alter global metabolism	35
Tonic TNF conditioning of macrophages safeguards stimulus‐specific inflammatory responses	35
Getting the message right	35
Gold mining nature for natural products	34
Isotope‐labeled amyloid‐β does not transmit to the brain in a prion‐like manner after peripheral administration	34
Constructive correction	34
Pericyte stem cells induce Ly6G ⁺ cell accumulation and immunotherapy resistance in pancreatic cancer	34
Inductive prediction in biology	34
mPFC DUSP1 mediates adolescent cocaine exposure‐induced higher sensitivity to drug in adulthood	33
CDK9 and PP2A regulate RNA polymerase II	33
The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins	32
The Autophagy Receptor TAX1BP1 ( T6BP ) improves antigen presentation by	32
TMBIM5 is the Ca ²⁺ /H ⁺ antiporter of mammalian mitochondria	32
The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging	31
Learning tricks from old dogs	31

KIAA1429 / VIRMA promotes breast cancer progression by m	31
NuRD‐independent Mi‐2 activity represses ectopic gene expression during neuronal maturation	31
Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress	31
Confusion	31
Evolution of pathogen virulence	30
PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability	30
Reducing oxidative protein folding alleviates senescence by minimizing ER‐to‐nucleus H ₂ O ₂ relea	30
An ULK1 / 2‐PXN mechanotransduction pathway suppresses breast cancer cell migration	30
Scholars in peril: when being a scientist can land you in jail (or worse)	30
Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway	30
Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding	29
Rab21 regulates caveolin‐1‐mediated endocytic trafficking to promote immature neurite pruning	29
Circadian oscillation in primary cilium length by clock genes regulates fibroblast cell migration	29
GM‐CSF suppresses antioxidant signaling and drives IL‐1β secretion through NRF2 downregulation	29
Cx43‐mediated sorting of miRNAs into extracellular vesicles	29
A plea for the ultimate optimism	29
Autism therapy at crossroads	29
ZBTB2 links p53 deficiency to HIF ‐1‐mediated hypoxia signaling to promote cancer aggressiveness	29
Optogenetic control of YAP cellular localisation and function	29
Diacylglycerols interact with the L2 lipidation site in TRPC3 to induce a sensitized channel state	28
FBL promotes cancer cell resistance to DNA damage and BRCA1 transcr	28
CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B	28
RNA polymerase II CTD is dispensable for transcription and required for termination in human cells	28
Hedgehog signaling can enhance glycolytic ATP production in the Drosophila wing disc	28
Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members	27
LINC00839 promotes colorectal cancer progression by recruiting RUVBL1 /Tip60 complexes to activate	27
TPLATE complex‐dependent endocytosis attenuates CLAVATA1 signaling for shoot apical meristem maintenance	27
DNA demethylation fine‐tunes IL ‐2 production during thymic regulatory T cell differentiation	27
Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6‐dependent pathway	27
Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice	27
Spns2/ S1P : it takes two to tango with inflammation and metabolic rewiring during sepsis	26
Descending dopaminergic pathway facilitates itch signal processing via activating spinal GRPR ⁺ neurons	26
We can do better	26
Waste management	26
Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation	26
The mind of a scientist	26
MOV10 recruits DCP2 to decap human LINE ‐1	26
Structural insights into coordinating 5S RNP rotation with ITS2 pre‐ RNA<	26
Ethical aspects of GMO regulation in the EU	25
The perceived decline of “disruptive” science and technology	25
Oxygen‐regulated post‐translation modifications as master signalling pathway in cells	25
The chromatin factor ROW cooperates with BEAF ‐32 in regulating long‐range inducible genes	25
The Drosophila mitotic spindle orientation machinery requires activation, not just localization	25
Keep biology weird	25
The splicing‐regulatory lncRNA NTRAS sustains vascular integrity	25
Estrogen receptor alpha signaling in dendritic cells modulates autoimmune disease phenotype in mice	24
Lipid and protein content profiling of isolated native autophagic vesicles	24
A trashed treasure	24
Combining organotypic tissue culture with light‐sheet microscopy ( OTCxLSFM ) to study glioma invasion	24
Differential roles of the fish chitinous membrane in gut barrier immunity and digestive compartments	24
Once in a lifetime	23
The cancer microbiome	23
Intracellular growth of Brucella is mediated by Dps‐dependent activation of ferritinophagy	23
The CRHR1 / CREB / REST signaling cascade regul	23
EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2	23
Bioenergetics of early life	23
hnRNP R negatively regulates transcription by modulating the association of P‐TEFb with 7SK	23
Structural study of UFL1‐UFC1 interaction uncovers the role of UFL1 N‐terminal helix in ufmylation	23
Adult neural stem cells and neurogenesis are resilient to intermittent fasting	23
Co‐evolution within the plant holobiont drives host performance	23