EMBO Reports

Article	Citations
Antibiotic resistance and persistence—Implications for human health and treatment perspectives	331
AI revolutions in biology	135
In‐depth and 3‐dimensional exploration of the budding yeast phosphoproteome	112
The interplay between DNA and histone methylation: molecular mechanisms and disease implications	100
RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss	95
The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity	90
Rapid endotheliitis and vascular damage characterize SARS‐CoV‐2 infection in a human lung‐on‐chip model	86
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development	83
Fighting antibiotic resistance—strategies and (pre)clinical developments to find new antibacterials	79
Root endophyte induced plant thermotolerance by constitutive chromatin modification at heat stress memory gene loci	79
Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism	78
Histone acetyltransferase 1 is a succinyltransferase for histones and non‐histones and promotes tumorigenesis	78
ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion	76
Exosome‐like nanoparticles from Mulberry bark prevent DSS‐induced colitis via the AhR/COPS8 pathway	74
Fusobacterium nucleatum secretes amyloid‐like FadA to enhance pathogenicity	72
Mitophagy receptor FUNDC1 is regulated by PGC‐1α/NRF1 to fine tune mitochondrial homeostasis	71
Phospholipid transfer function of PTPIP51 at mitochondria‐associated ER membranes	71
ALIX and ceramide differentially control polarized small extracellular vesicle release from epithelial cells	69
Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER‐phagy, and Collagen quality control	68
Transfer of LncRNA CRNDE in TAM‐derived exosomes is linked with cisplatin resistance in gastric cancer	66
N(6)‐methyladenosine‐binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay	66
TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease	63
Specific RNA interactions promote TDP‐43 multivalent phase separation and maintain liquid properties	61
Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease	60
Fermentation for future food systems	60

MAP kinase cascades in plant development and immune signaling	58
Aneuploid senescent cells activate NF‐κB to promote their immune clearance by NK cells	57
Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction	57
ER ‐phagy: selective autophagy of the endoplasmic reticulum	54
USP22 controls necroptosis by regulating receptor‐interacting protein kinase 3 ubiquitination	54
PPARα alleviates iron overload‐induced ferroptosis in mouse liver	54
Putting the brakes on phagocytosis: “don't‐eat‐me” signaling in physiology and disease	53
Curcumin prevents obesity by targeting TRAF4‐induced ubiquitylation in m 6 A‐dependent manner	47
Nanotube‐like processes facilitate material transfer between photoreceptors	47
Hsp90‐mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling	47
The mitochondrial Ca 2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis	47
GSDMD drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for NETosis	46
NeutrobodyPlex—monitoring SARS‐CoV‐2 neutralizing immune responses using nanobodies	46
Monitoring mitochondrial translation in living cells	45
Mitochondrial F 1 F O ATP synthase determines the local proton motive force at cristae rims	45
CTCF shapes chromatin structure and gene expression in health and disease	45
Best practices to ensure robust investigation of circular RNAs: pitfalls and tips	45
Alterations in mitochondrial morphology as a key driver of immunity and host defence	44
The struggle of a good friend getting old: cellular senescence in viral responses and therapy	44
Remodeling and activation mechanisms of outer arm dyneins revealed by cryo‐EM	43
piRNA‐ and siRNA‐mediated transcriptional repression in Drosophila , mice, and yeast: new insights and biodiversity	43
Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF	43
OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential	43
Succinylation of H3K122 destabilizes nucleosomes and enhances transcription	43
Interferon‐induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20	42
The phyB‐dependent induction of HY5 promotes iron uptake by systemically activating FER expression	42
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth	42
Iron‐induced NCOA4 condensation regulates ferritin fate and iron homeostasis	41
MPK3/6‐induced degradation of ARR1/10/12 promotes salt tolerance in Arabidopsis	41
H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing	40
Regulation and inhibition of the DNA sensor cGAS	39
Calcium signaling induces a partial EMT	39
The stress granule protein G3BP1 promotes pre‐condensation of cGAS to allow rapid responses to DNA	38
Single‐cell analysis reveals dynamic changes of neural cells in developing human spinal cord	37
Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming	37
Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling	36
Health disinformation & social media	36
Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures	36
Maintaining proteostasis under mechanical stress	36
PLETHORA‐WOX5 interaction and subnuclear localization control Arabidopsis root stem cell maintenance	35
Mild mitochondrial impairment enhances innate immunity and longevity through ATFS‐1 and p38 signaling	35
Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia	35
NLR receptors in plant immunity: making sense of the alphabet soup	35
A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection	35
SIRT3‐dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth	35
Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development	34
Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1	34
CUL2LRR1, TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle	34
Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole	34
SFRP1 modulates astrocyte‐to‐microglia crosstalk in acute and chronic neuroinflammation	34

Phase‐separated foci of EML4‐ALK facilitate signalling and depend upon an active kinase conformation	34
The FUS gene is dual‐coding with both proteins contributing to FUS ‐mediated toxicity	34
BioID reveals an ATG9A interaction with ATG13‐ATG101 in the degradation of p62/SQSTM1‐ubiquitin clusters	34
Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells	33
lncRNA‐encoded pep‐AP attenuates the pentose phosphate pathway and sensitizes colorectal cancer cells to Oxaliplatin	33
Get closer and make hotspots: liquid–liquid phase separation in plants	33
The ubiquitin ligation machinery in the defense against bacterial pathogens	33
Co‐evolution within the plant holobiont drives host performance	32
The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder	32
Biparatopic sybodies neutralize SARS‐CoV‐2 variants of concern and mitigate drug resistance	32
Redox activation of ATM enhances GSNOR translation to sustain mitophagy and tolerance to oxidative stress	32
Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons	32
Histone methyltransferase DOT1L controls state‐specific identity during B cell differentiation	31
m6A methylation promotes white‐to‐beige fat transition by facilitating Hif1a translation	31
PIDDosome‐induced p53‐dependent ploidy restriction facilitates hepatocarcinogenesis	31
Alternative splicing coupled mRNA decay shapes the temperature‐dependent transcriptome	31
Linking transport and translation of mRNAs with endosomes and mitochondria	31
USP42 protects ZNRF3/RNF43 from R‐spondin‐dependent clearance and inhibits Wnt signalling	30
Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice	30
Muscle‐derived exophers promote reproductive fitness	30
Atg1 kinase regulates autophagosome‐vacuole fusion by controlling SNARE bundling	30
Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere	30
Deubiquitinating enzymes UBP12 and UBP13 stabilize the brassinosteroid receptor BRI1	30
Quaking 5 suppresses TGF‐β‐induced EMT and cell invasion in lung adenocarcinoma	30
Plasmodium transcription repressor AP2‐O3 regulates sex‐specific identity of gene expression in female gametocytes	29
HP1 maintains protein stability of H3K9 methyltransferases and demethylases	29
Dengue virus NS1 protein conveys pro‐inflammatory signals by docking onto high‐density lipoproteins	29
ALS ‐linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain‐of‐function	29
Non‐redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression	29
MOAP‐1‐mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling	29
Bardet–Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self‐tolerance	29
TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment	29
TIFA has dual functions in Helicobacter pylori ‐induced classical and alternative NF‐κB pathways	28
Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains	28
TMBIM5 is the Ca 2+ /H + antiporter of mammalian mitochondria	28
Molecular networks of the FOXP2 transcription factor in the brain	28
Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1	28
Influenza A viruses limit NLRP3‐NEK7‐complex formation and pyroptosis in human macrophages	28
The human GID complex engages two independent modules for substrate recruitment	27
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1	27
Whole‐genome analysis of TET dioxygenase function in regulatory T cells	27
The unfolded protein response links tumor aneuploidy to local immune dysregulation	27
B1‐type cyclins control microtubule organization during cell division in Arabidopsis	27
Evolutionary remodelling of N‐terminal domain loops fine‐tunes SARS‐CoV‐2 spike	27
CDK inhibitor Palbociclib targets STING to alleviate autoinflammation	27
Biodiversity crisis or sixth mass extinction?	26
Physical and functional interactome atlas of human receptor tyrosine kinases	26
Toll‐like receptor 4 is activated by platinum and contributes to cisplatin‐induced ototoxicity	26
A multifaceted cellular damage repair and prevention pathway promotes high‐level tolerance to β‐lactam antibiotics	26
Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity	26
HOTAIR lncRNA promotes epithelial–mesenchymal transition by redistributing LSD1 at regulatory chromatin regions	26
Single‐cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland	26
STING agonism turns human T cells into interferon‐producing cells but impedes their functionality	26
MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking	26
MYC promotes cancer progression by modulating m6A modifications to suppress target gene translation	25
Local and systemic effects of microbiome‐derived metabolites	25
DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging	25
Nsp16 shields SARS–CoV ‐2 from efficient MDA5 sensing and IFIT1 ‐mediated restriction	25
Adaptive homeostasis and the p53 isoform network	25
N ‐acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages	25
IKKβ is required for the formation of the NLRP3 inflammasome	25
Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity	25
Phosphorylation by casein kinase 2 enhances the interaction between ER‐phagy receptor TEX264 and ATG8 proteins	25
Mobile late endosomes modulate peripheral endoplasmic reticulum network architecture	25
PLK1 regulates centrosome migration and spindle dynamics in male mouse meiosis	25
FAM111A induces nuclear dysfunction in disease and viral restriction	25
Quorum sensing governs a transmissive Legionella subpopulation at the pathogen vacuole periphery	24
Differential regulation of glycinergic and GABAergic nanocolumns at mixed inhibitory synapses	24
Engineering a customizable antibacterial T6SS‐based platform in Vibrio natriegens	24
Identification and characterization of in vitro expanded hematopoietic stem cells	24
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1	24
Nitrate triggered phosphoproteome changes and a PIN2 phosphosite modulating root system architecture	24
The androgen receptor depends on ligand‐binding domain dimerization for transcriptional activation	24
Modelling of primary ciliary dyskinesia using patient‐derived airway organoids	24
Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters	24
PML‐NB‐dependent type I interferon memory results in a restricted form of HSV latency	24
Actin filament oxidation by MICAL1 suppresses protections from cofilin‐induced disassembly	23
MiR‐342 controls Mycobacterium tuberculosis susceptibility by modulating inflammation and cell death	23
Degradation of WTAP blocks antiviral responses by reducing the m 6 A levels of IRF3 and IFNAR1 mRNA	23
Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation	23

From the freezer to the clinic	23
Composition, organization and mechanisms of the transition zone, a gate for the cilium	23
Current developments in antibiotic discovery	23
Chromatin accessibility dynamics during cell fate reprogramming	22
UBXD8 mediates mitochondria‐associated degradation to restrain apoptosis and mitophagy	22
FOXM1 network in association with TREM1 suppression regulates NET formation in diabetic foot ulcers	22
Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster	22
Human cerebral organoids reveal progenitor pathology in EML1‐linked cortical malformation	22
A binary effector module secreted by a type VI secretion system	22
Non‐apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence	22
Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR‐Cas9 screen	22
Modulation of phagosome phosphoinositide dynamics by a Legionella phosphoinositide 3‐kinase	22
LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5	22
Pseudomonas aeruginosa survives in epithelia by ExoS‐mediated inhibition of autophagy and mTOR	22
A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation	22
Biparatopic nanobodies protect mice from lethal challenge with SARS‐CoV‐2 variants of concern	21
METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m6A homeostasis	21
MITOL promotes cell survival by degrading Parkin during mitophagy	21
EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics	21
RGI‐GOLVEN signaling promotes cell surface immune receptor abundance to regulate plant immunity	21
Reflux of Endoplasmic Reticulum proteins to the cytosol inactivates tumor suppressors	21
LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1	21
HOIP limits anti‐tumor immunity by protecting against combined TNF and IFN‐gamma‐induced apoptosis	21
BAZ2A‐mediated repression via H3K14ac‐marked enhancers promotes prostate cancer stem cells	21
ATF3 induces RAB7 to govern autodegradation in paligenosis, a conserved cell plasticity program	21
Glial Hedgehog signalling and lipid metabolism regulate neural stem cell proliferation in Drosophila	21
A simple reverse genetics method to generate recombinant coronaviruses	20
Orphan nuclear receptor COUP‐TFII enhances myofibroblast glycolysis leading to kidney fibrosis	20
How physical forces drive the process of helical membrane protein folding	20
Molecular adaptations during viral epidemics	20
Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses	20
Functional coordination of non‐myocytes plays a key role in adult zebrafish heart regeneration	20
CDK9 and PP2A regulate RNA polymerase II transcription termination and coupled RNA maturation	20
Npas4 regulates medium spiny neuron physiology and gates cocaine‐induced hyperlocomotion	20
MYBL2 and ATM suppress replication stress in pluripotent stem cells	20
Regulation of ER‐derived membrane dynamics by the DedA domain‐containing proteins VMP1 and TMEM41B	19
Long non‐coding RNA TINCR suppresses metastatic melanoma dissemination by preventing ATF4 translation	19
Legionella‐ and host‐driven lipid flux at LCV‐ER membrane contact sites promotes vacuole remodeling	19
An ATG12‐ATG5‐TECPR1 E3‐like complex regulates unconventional LC3 lipidation at damaged lysosomes	19
Lysosomes in senescence and aging	19
EVL regulates VEGF receptor‐2 internalization and signaling in developmental angiogenesis	19
IL‐21 has a critical role in establishing germinal centers by amplifying early B cell proliferation	19
Using a bistable animal opsin for switchable and scalable optogenetic inhibition of neurons	19
Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness	19
Dissecting the cotranscriptome landscape of plants and their microbiota	19
MAPK signaling regulates c‐MYC for melanoma cell adaptation to asparagine restriction	19
Lysosomal K+ channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease	19
Pseudomonas syringae senses polyphenols via phosphorelay crosstalk to inhibit virulence	19
Placenta‐derived interferon‐stimulated gene 20 controls ZIKA virus infection	18
The deubiquitinase USP36 promotes snoRNP group SUMOylation and is essential for ribosome biogenesis	18
The dichotomy of yield and drought resistance	18
Lipid and protein content profiling of isolated native autophagic vesicles	18
Regulation of cGAS activity by RNA‐modulated phase separation	18
Hypoxia‐induced ELF3 promotes tumor angiogenesis through IGF1/IGF1R	18
Mitigating the ecological collapse of coral reef ecosystems	18
NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis	18
NPM1 ablation induces HSC aging and inflammation to develop myelodysplastic syndrome exacerbated by p53 loss	18
Cx43‐mediated sorting of miRNAs into extracellular vesicles	18
RAB6 and dynein drive post‐Golgi apical transport to prevent neuronal progenitor delamination	18
LncRNA Ctcflos orchestrates transcription and alternative splicing in thermogenic adipogenesis	18
Single‐cell transcriptomics identifies Gadd45b as a regulator of herpesvirus‐reactivating neurons	18
Integration of transcriptional and metabolic control in macrophage activation	18
Gradual centriole maturation associates with the mitotic surveillance pathway in mouse development	18
ER‐mitochondria contacts and cholesterol metabolism are disrupted by disease‐associated tau protein	17
CBX4 contributes to HIV‐1 latency by forming phase‐separated nuclear bodies and SUMOylating EZH2	17
Interferon‐induced transmembrane protein 3 (IFITM3) limits lethality of SARS‐CoV‐2 in mice	17
Non‐recombinogenic roles for Rad52 in translesion synthesis during DNA damage tolerance	17
BRLF1 suppresses RNA Pol III‐mediated RIG‐I inflammasome activation in the early EBV lytic lifecycle	17
Tnfaip2/exoc3 ‐driven lipid metabolism is essential for stem cell differentiation and organ homeostasis	17
Inositol‐requiring enzyme‐1 regulates phosphoinositide signaling lipids and macrophage growth	17
The Golgi microtubules regulate single cell durotaxis	17
Cyprinid‐specific duplicated membrane TLR5 senses dsRNA as functional homodimeric receptors	17
The divergence of mutation rates and spectra across the Tree of Life	17
Myeloid cell‐specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation	17
AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP‐170	17
Reciprocal control of translation and transcription in autism spectrum disorder	17
Sensing of mycobacterial arabinogalactan by galectin‐9 exacerbates mycobacterial infection	17
Cdc42‐Borg4‐Septin7 axis regulates HSC polarity and function	17
Malaria parasites release vesicle subpopulations with signatures of different destinations	17
Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2	17
Intertissue mechanical interactions shape the olfactory circuit in zebrafish	17
A new family ofCRISPR‐type V nucleases with C‐richPAMrecognition	17
O‐GlcNAcylation of TDP‐43 suppresses proteinopathies and promotes TDP‐43’s mRNA splicing activity	17
FTLD‐TDP assemblies seed neoaggregates with subtype‐specific features via a prion‐like cascade	16
Identification of TOR‐responsive slow‐cycling neoblasts in planarians	16
Chromatin remodeller CHD7 is required for GABAergic neuron development by promoting PAQR3 expression	16
mTORC1 activity negatively regulates human hair follicle growth and pigmentation	16
Metabolomics meets systems immunology	16
RNA‐binding protein RBM47 stabilizes IFNAR1 mRNA to potentiate host antiviral activity	16
Cancer‐secreted miRNAs regulate amino‐acid‐induced mTORC1 signaling and fibroblast protein synthesis	16
Single‐cell transcriptomic landscape of cardiac neural crest cell derivatives during development	16
Human‐specific ARHGAP11B ensures human‐like basal progenitor levels in hominid cerebral organoids	16
Sphingosine‐1‐phosphate controls endothelial sphingolipid homeostasis via ORMDL	16
Rab11‐FIP1 mediates epithelial‐mesenchymal transition and invasion in esophageal cancer	16
RGCC balances self‐renewal and neuronal differentiation of neural stem cells in the developing mammalian neocortex	16