OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Reports is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Through an ecological lens	160
Dynamic chromatin association of IκBα is regulated by acetylation and cleavage of histone H4	107
CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection	106
Concerns about academic freedom caused by the Russia–Ukraine War	105
Functional skewing of TRIM21‐SIRT5 interplay dictates IL‐1β production in DSS‐induced colitis	103
UBAP2L‐dependent coupling of PLK1 localization and stability during mitosis	99
The Golgi microtubules regulate single cell durotaxis	95
Lamin A‐mediated nuclear lamina integrity is required for proper ciliogenesis	92
SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3	89
Tissue resilience: lessons from social resilience	87
Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation	85
Global and precise identification of functional miRNA targets in mESCs by integrative analysis	83
LGBTIQ+N	82
The human touch	81
Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice	78
E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2	76
SCF ^FBXW7 regulates G2‐M progression through control of CCNL1	75
XIAP promotes melanoma growth by inducing tumour neutrophil infiltration	71
Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus	71
TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment	68
Dynamin‐like proteins mediate extracellular vesicle secretion in Mycobacterium tuberculosis	68
lncRNA‐encoded pep‐AP attenuates the pentose phosphate pathway and sensitizes colorectal cancer cells to Oxaliplatin	67
Aire‐dependent transcripts escape Raver2‐induced splice‐event inclusion in the thymic epithelium	62
The post‐translational regulation of transcription factor EB (TFEB) in health and disease	61
The mission to ensure continued funding for excellent basic research	60

Enhancing Spns2/S1P in macrophages alleviates hyperinflammation and prevents immunosuppression in sepsis	59
Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair	58
METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m⁶A homeostasis	57
piRNA‐ and siRNA‐mediated transcriptional repression in Drosophila , mice, and yeast: new insights and biodiversity	55
The transcriptional regulator Sin3A balances IL‐17A and Foxp3 expression in primary CD4 T cells	52
Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis	52
The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive‐strand R	52
Morphofunctional changes at the active zone during synaptic vesicle exocytosis	51
Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster	50
Single‐cell analysis reveals dynamic changes of neural cells in developing human spinal cord	50
Zika virus alters centrosome organization to suppress the innate immune response	50
Functions of animal microRNA‐encoded peptides: the race is on!	49
Hair follicle stem cell progeny heal blisters while pausing skin development	49
Energetic landscape of polycystin channel gating	48
pH regulates hematopoietic stem cell potential via polyamines	48
Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo	48
Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice	46
Striking the right balance between youth and experience	45
Undergraduate students in research	45
Animals do count	44
Tissue‐like environments shape functional interactions of HIV‐1 with immature dendritic cells	44
Sci‐Con	44
A Good Day for Helminths: how parasite‐derived GDH suppresses inflammatory responses	44
SPTing across condensates: SEC‐mediated translocation of SPT complex from pausing condensates to elongation condensates	44
A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength	43
Sequestration of LINE‐1 in cytosolic aggregates by MOV10 restricts retrotransposition	42
Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network	42
Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER‐phagy, and Collagen quality control	41
Resting natural killer cell homeostasis relies on tryptophan/NAD⁺ metabolism and HIF‐1α	41
PRMT5 links lipid metabolism to contractile function of skeletal muscles	41
Scalable RT‐LAMP‐based SARS‐CoV‐2 testing for infection surveillance with applications in pandemic preparedness	41
IL‐21 has a critical role in establishing germinal centers by amplifying early B cell proliferation	41
Noncanonical Wnt signaling promotes colon tumor growth, chemoresistance and tumor fibroblast activation	41
Dan Salah Tawfik (1955‐2021)—A giant of protein evolution	40
The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis	40
Vitamin D receptor enhances NLRC4 inflammasome activation by promoting NAIPs–NLRC4 association	40
FOXM1 network in association with TREM1 suppression regulates NET formation in diabetic foot ulcers	39
Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters	39
Biparatopic sybodies neutralize SARS‐CoV‐2 variants of concern and mitigate drug resistance	39
STAT5bis a key effector ofNRG‐1/ERBB4‐mediated myocardial growth	39
DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres	39
Tick‐borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2	39
Autophagy orchestrates the crosstalk between cells and organs	38
Bclaf1 regulates c‐FLIP expression and protects cells from TNF‐induced apoptosis and tissue injury	38
A human coronavirus OC43‐derived polypeptide causes neuropathic pain	38
BTNL2 promotes colitis‐associated tumorigenesis in mice by regulating IL‐22 production	37
Specific N‐glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning	37
Single cell clonal analysis identifies an AID ‐dependent pathway of plasma cell differentiation	37
ER ‐phagy: selective autophagy of the endoplasmic reticulum	37
The B56α subunit of PP2A is necessary for mesenchymal stem cell commitment to adipocyte	37

#IchbinHannah and the fight for permanent jobs for postdocs	37
Bipolar‐associated miR‐499‐5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2	37
DJ‐1 depletion prevents immunoaging in T‐cell compartments	36
Viral diseases and the brain	36
The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity	36
A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation	35
Introducing quality measures in an academic research consortium	35
Evolutionary remodelling of N‐terminal domain loops fine‐tunes SARS‐CoV‐2 spike	35
GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1‐dependent manner	35
The regulation of human blastoid research	34
A highly conserved pocket on PP2A‐B56 is required for hSgo1 binding and cohesion protection during mitosis	34
Malaria parasites release vesicle subpopulations with signatures of different destinations	34
Understanding redundancy and resilience	34
Open reading frame dominance indicates protein‐coding potential of RNAs	33
Fish faeces and ocean life	33
Ovol1/2 loss‐induced epidermal defects elicit skin immune activation and alter global metabolism	33
Getting the message right	33
Constructive correction	32
mPFC DUSP1 mediates adolescent cocaine exposure‐induced higher sensitivity to drug in adulthood	32
Pericyte stem cells induce Ly6G⁺ cell accumulation and immunotherapy resistance in pancreatic cancer	32
CACGAACTACCCTAA	32
Powering on cGAMP mini factories	32
Isotope‐labeled amyloid‐β does not transmit to the brain in a prion‐like manner after peripheral administration	32
Gold mining nature for natural products	32
Inductive prediction in biology	32
Interaction with the CCT chaperonin complex limits APOBEC3A cytidine deaminase cytotoxicity	32
Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development	31
Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation	31
The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins	31
Tonic TNF conditioning of macrophages safeguards stimulus‐specific inflammatory responses	31
TMBIM5 is the Ca ²⁺ /H ⁺ antiporter of mammalian mitochondria	31
A need for recalibrating access and benefit sharing	31
On predictions and laws in biological evolution	31
Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus	30
The human GID complex engages two independent modules for substrate recruitment	30
CDK9 and PP2A regulate RNA polymerase II transcription termination and coupled RNA maturation	30
Phase‐separated foci of EML4‐ALK facilitate signalling and depend upon an active kinase conformation	30
Evolution of pathogen virulence	29
KIAA1429/VIRMA promotes breast cancer progression by m⁶A‐dependent cytosolic HAS2 stabilization	29
When will it ever end? When will it ever end?	29
Reducing oxidative protein folding alleviates senescence by minimizing ER‐to‐nucleus H₂O₂ release	28
Down on the farm	28
Confusion	28
NuRD‐independent Mi‐2 activity represses ectopic gene expression during neuronal maturation	28
HP1γ binding pre‐mRNA intronic repeats modulates RNA splicing decisions	28
Mycobacterium tuberculosis : the honey badger of pathogens	28
Learning tricks from old dogs	28
Pervasive compartment‐specific regulation of gene expression during homeostatic synaptic scaling	27
PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability	27
Intra‐epithelial non‐canonical Activin A signaling safeguards prostate progenitor quiescence	27
The Autophagy Receptor TAX1BP1 ( T6BP ) improves antigen presentation by MHC‐II molecules	27
The need for sustainable leadership in academia	27
Phosphorylation by casein kinase 2 enhances the interaction between ER‐phagy receptor TEX264 and ATG8 proteins	26
Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria	26
Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress	26
The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging	26
A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection	25
Optogenetic control of YAP cellular localisation and function	25
Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway	25
Scholars in peril: when being a scientist can land you in jail (or worse)	25
Bench science	25
A plea for the ultimate optimism	25
New model integrates innate responses, PML‐NB formation, epigenetic control and reactivation from latency	25
Foxm1 regulates neural progenitor fate during spinal cord regeneration	25
GM‐CSF suppresses antioxidant signaling and drives IL‐1β secretion through NRF2 downregulation	25
OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP‐mediated microtubule anchoring	24
ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness	24
Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding	24
CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B	24
Circadian oscillation in primary cilium length by clock genes regulates fibroblast cell migration	24
F‐domain valency determines outcome of signaling through the angiopoietin pathway	24
Confessions of a microscope hoarder	24
An ULK1/2‐PXN mechanotransduction pathway suppresses breast cancer cell migration	24
Rabaptin5 targets autophagy to damaged endosomes and Salmonella vacuoles via FIP200 and ATG16L1	24
Ub and Dub of RNF43/ZNRF3 in the WNT signalling pathway	23
Diacylglycerols interact with the L2 lipidation site in TRPC3 to induce a sensitized channel state	23
DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation	23
Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6‐dependent pathway	23
Hedgehog signaling can enhance glycolytic ATP production in the Drosophila wing disc	23
Cx43‐mediated sorting of miRNAs into extracellular vesicles	23

Interferon‐induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20	23
Rab21 regulates caveolin‐1‐mediated endocytic trafficking to promote immature neurite pruning	23
RNA polymerase II CTD is dispensable for transcription and required for termination in human cells	23
Autism therapy at crossroads	23
TPLATE complex‐dependent endocytosis attenuates CLAVATA1 signaling for shoot apical meristem maintenance	23
MAP kinase cascades in plant development and immune signaling	22
Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice	22
Mitochondrial F ₁ F _O ATP synthase determines the local proton motive force at cristae rims	22
FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1	22
IKKβ is required for the formation of the NLRP3 inflammasome	22
Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis	22
BRD9 is a druggable component of interferon‐stimulated gene expression and antiviral activity	22
m6A methylation promotes white‐to‐beige fat transition by facilitating Hif1a translation	22
Dual control of dopamine in Drosophila myeloid‐like progenitor cell proliferation and regulation of lymph gland growth	22
LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1	22
Oxygen‐regulated post‐translation modifications as master signalling pathway in cells	21
We can do better	21
The mind of a scientist	21
Descending dopaminergic pathway facilitates itch signal processing via activating spinal GRPR⁺ neurons	21
USP17 is required for peripheral trafficking of lysosomes	21
Transgenerational epigenetic information through the sperm	21
Waste management	21
Endothelial‐immune crosstalk contributes to vasculopathy in nonalcoholic fatty liver disease	21
The Drosophila mitotic spindle orientation machinery requires activation, not just localization	20
Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation	20
Two redundant ubiquitin‐dependent pathways of BRCA1 localization to DNA damage sites	20
Alcodemia: are we training our students to be great thinkers or great drinkers?	20
LincRNA‐EPS impairs host antiviral immunity by antagonizing viral RNA–PKR interaction	20
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1	20
Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation	20
Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members	20
The splicing‐regulatory lncRNA NTRAS sustains vascular integrity	20
Fatty acid oxidation is required for embryonic stem cell survival during metabolic stress	20
MOV10 recruits DCP2 to decap human LINE‐1 RNA by forming large cytoplasmic granules with phase separation properties	20
Exosome‐like nanoparticles from Mulberry bark prevent DSS‐induced colitis via the AhR/COPS8 pathway	20
The perceived decline of “disruptive” science and technology	19
Keep biology weird	19
CK1‐mediated phosphorylation of FAM110A promotes its interaction with mitotic spindle and controls chromosomal alignment	19
The chromatin factorROWcooperates withBEAF‐32 in regulating long‐range inducible genes	19
miR‐183 and miR‐96 orchestrate both glucose and fat utilization in skeletal muscle	19
A trashed treasure	19
Combining organotypic tissue culture with light‐sheet microscopy (OTCxLSFM) to study glioma invasion	19
Piwi/piRNAs control food intake by promoting neuropeptide F expression in locusts	19
Differential roles of the fish chitinous membrane in gut barrier immunity and digestive compartments	19
An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase	18
Engineering a customizable antibacterial T6SS‐based platform in Vibrio natriegens	18
Ethical aspects of GMO regulation in the EU	18
The obesity‐linked human lncRNA AATBC stimulates mitochondrial function in adipocytes	18
The cancer microbiome	18
Lipid and protein content profiling of isolated native autophagic vesicles	18
Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole	18
Structural study of UFL1‐UFC1 interaction uncovers the role of UFL1 N‐terminal helix in ufmylation	18
Once in a lifetime	18
Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere	18
Estrogen receptor alpha signaling in dendritic cells modulates autoimmune disease phenotype in mice	18
NPM1 ablation induces HSC aging and inflammation to develop myelodysplastic syndrome exacerbated by p53 loss	18
Bioenergetics of early life	18
Lipin‐2 regulates the antiviral and anti‐inflammatory responses to interferon	18
Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV	17
The human FOXM1 homolog promotes basal progenitor cell proliferation and cortical folding in mouse	17
Intracellular growth of Brucella is mediated by Dps‐dependent activation of ferritinophagy	17
EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole	17
Plasmodium sporozoite disintegration during skin passage limits malaria parasite transmission	17
The taste of vitamin C inDrosophila	17
SARS‐CoV‐2‐related bat virus behavior in human‐relevant models sheds light on the origin of COVID‐19	17
The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties	17
Osteoclasts adapt to physioxia perturbation through DNA demethylation	17
MiR‐342 controls Mycobacterium tuberculosis susceptibility by modulating inflammation and cell death	17