EMBO Reports

Papers
(The TQCC of EMBO Reports is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
ArticleCitations
Mitochondrial DNA in inflammation and immunity396
Antibiotic resistance and persistence—Implications for human health and treatment perspectives203
The evolving landscape around genome editing in agriculture113
AI revolutions in biology103
PINK 1 phosphorylates Drp1 S616 to regulate mitophagy‐independent mitochondrial dynamics103
Cristae undergo continuous cycles of membrane remodelling in a MICOS ‐dependent manner95
In‐depth and 3‐dimensional exploration of the budding yeast phosphoproteome93
Ageing, metabolism and the intestine85
RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss75
YTHDF 1‐mediated translation amplifies Wnt‐driven intestinal stemness75
Rapid endotheliitis and vascular damage characterize SARS‐CoV‐2 infection in a human lung‐on‐chip model74
The interplay between DNA and histone methylation: molecular mechanisms and disease implications72
Cell cycle dynamics of lamina‐associated DNA71
Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress67
Root endophyte induced plant thermotolerance by constitutive chromatin modification at heat stress memory gene loci67
The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity67
Respiratory supercomplexes enhance electron transport by decreasing cytochrome c diffusion distance66
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development65
SARS‐CoV‐2 evades immune detection in alveolar macrophages64
SIRT 2‐dependent IDH 1 deacetylation inhibits colorectal cancer and liver metastases64
USP 1 deubiquitinates Akt to inhibit PI 3K‐Akt‐FoxO signaling in muscle during prolonged starvation61
Histone acetyltransferase 1 is a succinyltransferase for histones and non‐histones and promotes tumorigenesis60
Chemokines and galectins form heterodimers to modulate inflammation59
Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca 2+ ‐dependent death of cancer cells58
Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish57
Iron loss triggers mitophagy through induction of mitochondrial ferritin57
Mitochondrial protein biogenesis in the synapse is supported by local translation57
Healthy soils for healthy plants for healthy humans55
A conserved ATG2‐GABARAP family interaction is critical for phagophore formation55
N(6)‐methyladenosine‐binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay54
Androgen receptor‐regulated circ FNTA activates KRAS signaling to promote bladder cancer invasion54
Mitochondrial transplantation—a possible therapeutic for mitochondrial dysfunction?53
Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism53
Prostate cancer cell‐intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone53
Transfer of LncRNA CRNDE in TAM‐derived exosomes is linked with cisplatin resistance in gastric cancer53
From deficit to dialogue in science communication52
Fusobacterium nucleatum secretes amyloid‐like FadA to enhance pathogenicity52
Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take52
Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER‐phagy, and Collagen quality control52
ALIX and ceramide differentially control polarized small extracellular vesicle release from epithelial cells51
Epstein–Barr virus‐derived circular RNA LMP 2A induces stemness in EBV ‐associated gastric cancer51
The 18S ribosomal RNA m 6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila51
The Arabidopsis lncRNA ASCO modulates the transcriptome through interaction with splicing factors51
Mitophagy receptor FUNDC1 is regulated by PGC‐1α/NRF1 to fine tune mitochondrial homeostasis51
Transcription factor CDF4 promotes leaf senescence and floral organ abscission by regulating abscisic acid and reactive oxygen species pathways in Arabidopsis51
Systemic effects of mitochondrial stress50
Loss of TMEM 106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice49
ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion49
Mitochondrial DNA heteroplasmy in disease and targeted nuclease‐based therapeutic approaches49
Phospholipid transfer function of PTPIP51 at mitochondria‐associated ER membranes49
Exosome‐like nanoparticles from Mulberry bark prevent DSS‐induced colitis via the AhR/COPS8 pathway46
Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance46
Key phosphorylation sites in GPCR s orchestrate the contribution of β‐Arrestin 1 in ERK 1/2 activation45
USP22 controls necroptosis by regulating receptor‐interacting protein kinase 3 ubiquitination45
N‐glycosylation of PD‐1 promotes binding of camrelizumab43
Autoimmunity gene IRGM suppresses cGASSTING and RIG ‐I‐ 43
Fighting antibiotic resistance—strategies and (pre)clinical developments to find new antibacterials43
The long journey towards standards for engineering biosystems43
Mentoring minority trainees42
Irgm2 and Gate‐16 cooperatively dampen Gram‐negative bacteria‐induced caspase‐11 response42
Specific RNA interactions promote TDP‐43 multivalent phase separation and maintain liquid properties42
Fermentation for future food systems42
Transfer of extracellular vesicle‐micro RNA controls germinal center reaction and antibody production42
The spread of the COVID ‐19 coronavirus42
Glucose uptake to guard cells via STP transporters provides carbon sources for stomatal opening and plant growth42
A malectin‐like receptor kinase regulates cell death and pattern‐triggered immunity in soybean41
TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease41
HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle‐resident mesenchymal cells41
The 18S rRNA m 6 A methyltransferase METTL 5 promotes mouse embryonic stem cell differentiation41
Human RAP 1 specifically protects telomeres of senescent cells from DNA damage40
NeutrobodyPlex—monitoring SARS‐CoV‐2 neutralizing immune responses using nanobodies40
Dynamin‐related Irgm proteins modulate LPS‐induced caspase‐11 activation and septic shock39
KUP 9 maintains root meristem activity by regulating K + and auxin homeostasis in response to low K39
Curcumin prevents obesity by targeting TRAF4‐induced ubiquitylation in m 6 A‐dependent manner39
Aneuploid senescent cells activate NF‐κB to promote their immune clearance by NK cells39
Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction39
Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish39
Nanotube‐like processes facilitate material transfer between photoreceptors38
TLR4‐dependent shaping of the wound site by MSCs accelerates wound healing38
Hsp90‐mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling37
ECE2 regulates neurogenesis and neuronal migration during human cortical development37
Nesprin‐2 accumulates at the front of the nucleus during confined cell migration37
The mitochondrial Ca 2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis37
Putting the brakes on phagocytosis: “don't‐eat‐me” signaling in physiology and disease37
Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease36
PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal‐to‐zygotic transition36
H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing36
Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures35
Myf6/MRF4 is a myogenic niche regulator required for the maintenance of the muscle stem cell pool35
MAP kinase cascades in plant development and immune signaling35
Loss of TMEM 106B potentiates lysosomal and FTLD ‐like pathology in progranulin‐deficient mice35
The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation34
AP ‐2 reduces amyloidogenesis by promoting BACE 1 trafficking and degradation in neurons34
The struggle of a good friend getting old: cellular senescence in viral responses and therapy34
Remodeling and activation mechanisms of outer arm dyneins revealed by cryo‐EM34
FAM111 protease activity undermines cellular fitness and is amplified by gain‐of‐function mutations in human disease34
Interferon‐induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG2034
MPK3/6‐induced degradation of ARR1/10/12 promotes salt tolerance in Arabidopsis33
A revised model of TRAIL ‐R2 DISC assembly explains how FLIP (L) can inhibit or promote apoptos33
The phyB‐dependent induction of HY5 promotes iron uptake by systemically activating FER expression33
Succinylation of H3K122 destabilizes nucleosomes and enhances transcription33
Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice32
Fast news or fake news?32
Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF32
GSDMD drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for NETosis32
Plants, climate and humans32
Best practices to ensure robust investigation of circular RNAs: pitfalls and tips32
Calcium signaling induces a partial EMT32
O‐glycan initiation directs distinct biological pathways and controls epithelial differentiation32
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth31
Nuclear envelope rupture and NET formation is driven by PKCα‐mediated lamin B disassembly31
Chronic cold exposure enhances glucose oxidation in brown adipose tissue31
Monitoring mitochondrial translation in living cells30
A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection30
Intellectual disability‐associated gene ftsj1 is responsible for 2′‐O‐methylation of specific tRNAs30
Alterations in mitochondrial morphology as a key driver of immunity and host defence29
Single‐cell analysis reveals dynamic changes of neural cells in developing human spinal cord29
ER ‐phagy: selective autophagy of the endoplasmic reticulum29
CTCF shapes chromatin structure and gene expression in health and disease29
Structure of RyR1 in native membranes29
OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential29
The FUS gene is dual‐coding with both proteins contributing to FUS ‐mediated toxicity28
TIFA has dual functions in Helicobacter pylori ‐induced classical and alternative NF‐κB pathways28
piRNA‐ and siRNA‐mediated transcriptional repression in Drosophila , mice, and yeast: new insights and biodiversity28
Get closer and make hotspots: liquid–liquid phase separation in plants28
The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT –liver communication27
Trigger factor is a bona fide secretory pathway chaperone that interacts with SecB and the translocase27
High‐grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF‐127
PPARα alleviates iron overload‐induced ferroptosis in mouse liver27
Redox activation of ATM enhances GSNOR translation to sustain mitophagy and tolerance to oxidative stress27
Organismal benefits of transcription speed control at gene boundaries27
PIDDosome‐induced p53‐dependent ploidy restriction facilitates hepatocarcinogenesis27
Phase‐separated foci of EML4‐ALK facilitate signalling and depend upon an active kinase conformation27
Regulation and inhibition of the DNA sensor cGAS27
Hippocampal CD 39/ ENTPD 1 promotes mouse depression‐like behavior through hydrolyzing extracellular ATP26
Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons26
COVID ‐19 and misinformation26
Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development26
Histone methyltransferase DOT1L controls state‐specific identity during B cell differentiation26
Bardet–Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self‐tolerance26
Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA26
Alternative splicing coupled mRNA decay shapes the temperature‐dependent transcriptome26
The ubiquitin ligation machinery in the defense against bacterial pathogens26
Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub125
20,000 picometers under the OMM: diving into the vastness of mitochondrial metabolite transport25
Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling25
Mitochondrial F 1 F O ATP synthase determines the local proton motive force at cristae rims25
Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia25
The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder25
Linking transport and translation of mRNAs with endosomes and mitochondria25
Placensin is a glucogenic hormone secreted by human placenta25
Transient Dux expression facilitates nuclear transfer and induced pluripotent stem cell reprogramming25
Homologous recombination and Mus81 promote replication completion in response to replication fork blockage25
Long non‐coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex25
Maintaining proteostasis under mechanical stress25
Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development25
Small‐molecule inhibition of aging‐associated chromosomal instability delays cellular senescence25
Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole25
The stress granule protein G3BP1 promotes pre‐condensation of cGAS to allow rapid responses to DNA25
Micro RNA ‐195 controls MICU 1 expression and tumor growth in ovarian cancer25
CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage25
Proteasome mapping reveals sexual dimorphism in tissue‐specific sensitivity to protein aggregations24
SFRP1 modulates astrocyte‐to‐microglia crosstalk in acute and chronic neuroinflammation24
TET 2 promotes anti‐tumor immunity by governing G‐ MDSC s and CD 8 + T‐c24
Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance24
Biparatopic sybodies neutralize SARS‐CoV‐2 variants of concern and mitigate drug resistance24
CUL2LRR1, TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle24
Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast24
Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice24
BioID reveals an ATG9A interaction with ATG13‐ATG101 in the degradation of p62/SQSTM1‐ubiquitin clusters24
A one‐carbon path for fixing CO 224
HOTAIR lncRNA promotes epithelial–mesenchymal transition by redistributing LSD1 at regulatory chromatin regions24
Mild mitochondrial impairment enhances innate immunity and longevity through ATFS‐1 and p38 signaling23
m6A methylation promotes white‐to‐beige fat transition by facilitating Hif1a translation23
A multifaceted cellular damage repair and prevention pathway promotes high‐level tolerance to β‐lactam antibiotics23
Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming23
Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates23
Quaking 5 suppresses TGF‐β‐induced EMT and cell invasion in lung adenocarcinoma23
TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution23
Class IA PI3Ks regulate subcellular and functional dynamics of IDO123
Health disinformation & social media23
Plasmodium transcription repressor AP2‐O3 regulates sex‐specific identity of gene expression in female gametocytes23
VEGF‐B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content23
lncRNA‐encoded pep‐AP attenuates the pentose phosphate pathway and sensitizes colorectal cancer cells to Oxaliplatin23
Single‐cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland23
So close, no matter how far: multiple paths connecting transcription to mRNA translation in eukaryotes23
Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains23
Calcium regulation of stem cells23
HMCES safeguards replication from oxidative stress and ensures error‐free repair22
SGTA associates with nascent membrane protein precursors22
Lipoic acid rejuvenates aged intestinal stem cells by preventing age‐associated endosome reduction22
Protein phosphatase PP2A regulates microtubule orientation and dendrite pruning in Drosophila22
USP42 protects ZNRF3/RNF43 from R‐spondin‐dependent clearance and inhibits Wnt signalling22
Exploring GPCR‐arrestin interfaces with genetically encoded crosslinkers22
Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity22
Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity22
MOAP‐1‐mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling22
Amyloid aggregates accumulate in melanoma metastasis modulating YAP activity22
The mechanoreceptor DEG‐1 regulates cold tolerance in Caenorhabditis elegans22
PDS 5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis21
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis121
IKKβ is required for the formation of the NLRP3 inflammasome21
Deubiquitinating enzymes UBP12 and UBP13 stabilize the brassinosteroid receptor BRI121
Actin filament oxidation by MICAL1 suppresses protections from cofilin‐induced disassembly21
MiR‐342 controls Mycobacterium tuberculosis susceptibility by modulating inflammation and cell death21
DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging21
TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment21
EphA2 phosphorylates NLRP 3 and inhibits inflammasomes in airway epithelial cells21
Modelling of primary ciliary dyskinesia using patient‐derived airway organoids21
Emerging pathogen evolution21
Non‐redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression21
Atg1 kinase regulates autophagosome‐vacuole fusion by controlling SNARE bundling21
B1‐type cyclins control microtubule organization during cell division in Arabidopsis21
Biodiversity crisis or sixth mass extinction?20
ALS ‐linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain‐of‐function20
Mobile late endosomes modulate peripheral endoplasmic reticulum network architecture20
Nitrate triggered phosphoproteome changes and a PIN2 phosphosite modulating root system architecture20
Molecular networks of the FOXP2 transcription factor in the brain20
CDK inhibitor Palbociclib targets STING to alleviate autoinflammation20
Influenza A viruses limit NLRP3‐NEK7‐complex formation and pyroptosis in human macrophages20
PP2A phosphatase is required for dendrite pruning via actin regulation in Drosophila20
Differential regulation of glycinergic and GABAergic nanocolumns at mixed inhibitory synapses20
MYC promotes cancer progression by modulating m6A modifications to suppress target gene translation20
Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere20
A common molecular mechanism underlies the role of Mps1 in chromosome biorientation and the spindle assembly checkpoint20
The unfolded protein response links tumor aneuploidy to local immune dysregulation20
MITOL promotes cell survival by degrading Parkin during mitophagy20
Degradation of WTAP blocks antiviral responses by reducing the m 6 A levels of IRF3 and IFNAR1 mRNA20
A cell atlas of adult muscle precursors uncovers early events in fibre‐type divergence in Drosophila20
N ‐acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages20
Non‐apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence20
Neuronal lipolysis participates in PUFA‐mediated neural function and neurodegeneration20
Dynamics of Staphylococcus aureus Cas9 in DNA target Association and Dissociation20
Long non‐coding RNA TINCR suppresses metastatic melanoma dissemination by preventing ATF4 translation19
Function of the SNARE Ykt6 on autophagosomes requires the Dsl1 complex and the Atg1 kinase complex19
Quorum sensing governs a transmissive Legionella subpopulation at the pathogen vacuole periphery19
ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids19
Adherens junction remodelling during mitotic rounding of pseudostratified epithelial cells19
Gi‐coupled receptor activation potentiates Piezo2 currents via Gβγ19
SMaRT lncRNA controls translation of a G‐quadruplex‐containing mRNA antagonizing the DHX36 helicase19
Muscle‐derived exophers promote reproductive fitness19
Using a bistable animal opsin for switchable and scalable optogenetic inhibition of neurons19
PEBP 1 suppresses HIV transcription and induces latency by inactivating MAPK / NF 19
LGR 5 controls extracellular matrix production by stem cells in the developing intestine19
Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters19
PLK1 regulates centrosome migration and spindle dynamics in male mouse meiosis19
PML‐NB‐dependent type I interferon memory results in a restricted form of HSV latency19
IGF 1R regulates retrograde axonal transport of signalling endosomes in motor neurons19
The power of saying no19
Pseudomonas aeruginosa survives in epithelia by ExoS‐mediated inhibition of autophagy and mTOR19
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