OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Reports is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
The mission to ensure continued funding for excellent basic research	239
LGBTIQ+N	173
Erratum To: The Golgi microtubules regulate single cell durotaxis	149
UBAP2L‐dependent coupling of PLK1 localization and stability during mitosis	149
Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation	147
SCFFBXW7 regulates G2‐M progression through control of CCNL1 ubiquitination	143
Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair	129
CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection	121
Through an ecological lens	98
SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3	85
E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2	82
Enhancing Spns2/S1P in macrophages alleviates hyperinflammation and prevents immunosuppression in sepsis	73
Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus	72
The post‐translational regulation of transcription factor EB (TFEB) in health and disease	70
METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m6A homeostasis	70
Dynamin‐like proteins mediate extracellular vesicle secretion in Mycobacterium tuberculosis	68
Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis	63
Morphofunctional changes at the active zone during synaptic vesicle exocytosis	62
A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength	55
Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice	55
Tissue‐like environments shape functional interactions of HIV‐1 with immature dendritic cells	54
SPTing across condensates: SEC‐mediated translocation of SPT complex from pausing condensates to elongation condensates	54
Scalable RT‐LAMP‐based SARS‐CoV‐2 testing for infection surveillance with applications in pandemic preparedness	54
Energetic landscape of polycystin channel gating	53
The transcriptional regulator Sin3A balances IL‐17A and Foxp3 expression in primary CD4 T cells	52

Resting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF‐1α	51
Striking the right balance between youth and experience	51
pH regulates hematopoietic stem cell potential via polyamines	48
Noncanonical Wnt signaling promotes colon tumor growth, chemoresistance and tumor fibroblast activation	48
PRMT5 links lipid metabolism to contractile function of skeletal muscles	48
The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive‐strand RNA viruses	47
Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network	47
Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo	46
The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity	44
GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1‐dependent manner	43
The regulation of human blastoid research	42
Autophagy orchestrates the crosstalk between cells and organs	42
Single cell clonal analysis identifies an AID‐dependent pathway of plasma cell differentiation	42
BTNL2 promotes colitis‐associated tumorigenesis in mice by regulating IL‐22 production	41
STAT5b is a key effector of NRG‐1/ERBB4‐mediated myocardial growth	40
Bipolar‐associated miR‐499‐5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2	39
Tick‐borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2	39
Evolutionary remodelling of N‐terminal domain loops fine‐tunes SARS‐CoV‐2 spike	39
DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres	39
mPFC DUSP1 mediates adolescent cocaine exposure‐induced higher sensitivity to drug in adulthood	38
Ovol1/2 loss‐induced epidermal defects elicit skin immune activation and alter global metabolism	38
Getting the message right	38
TMBIM5 is the Ca2+/H+ antiporter of mammalian mitochondria	37
Tonic TNF conditioning of macrophages safeguards stimulus‐specific inflammatory responses	37
CDK9 and PP2A regulate RNA polymerase II transcription termination and coupled RNA maturation	37
Constructive correction	37
The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins	36
Learning tricks from old dogs	36
Pericyte stem cells induce Ly6G+ cell accumulation and immunotherapy resistance in pancreatic cancer	36
The Autophagy Receptor TAX1BP1 (T6BP) improves antigen presentation by MHC‐II molecules	36
Confusion	36
Evolution of pathogen virulence	36
NuRD‐independent Mi‐2 activity represses ectopic gene expression during neuronal maturation	35
PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability	35
KIAA1429/VIRMA promotes breast cancer progression by m6A‐dependent cytosolic HAS2 stabilization	35
Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress	34
The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging	34
Reducing oxidative protein folding alleviates senescence by minimizing ER‐to‐nucleus H2O2 release	33
A plea for the ultimate optimism	33
Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding	33
ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness	33
Scholars in peril: when being a scientist can land you in jail (or worse)	32
Circadian oscillation in primary cilium length by clock genes regulates fibroblast cell migration	32
Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway	31
An ULK1/2‐PXN mechanotransduction pathway suppresses breast cancer cell migration	31
DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation	31
Autism therapy at crossroads	31
TPLATE complex‐dependent endocytosis attenuates CLAVATA1 signaling for shoot apical meristem maintenance	30
MOV10 recruits DCP2 to decap human LINE‐1 RNA by forming large cytoplasmic granules with phase separation properties	30
Hedgehog signaling can enhance glycolytic ATP production in the Drosophila wing disc	30

Rab21 regulates caveolin‐1‐mediated endocytic trafficking to promote immature neurite pruning	30
RNA polymerase II CTD is dispensable for transcription and required for termination in human cells	30
Descending dopaminergic pathway facilitates itch signal processing via activating spinal GRPR+ neurons	30
Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice	30
FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1	30
The Drosophila mitotic spindle orientation machinery requires activation, not just localization	30
Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis	29
Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation	29
Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation	29
The mind of a scientist	29
We can do better	29
Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members	29
Oxygen‐regulated post‐translation modifications as master signalling pathway in cells	28
Lipid and protein content profiling of isolated native autophagic vesicles	28
The chromatin factor ROW cooperates with BEAF‐32 in regulating long‐range inducible genes	27
Combining organotypic tissue culture with light‐sheet microscopy (OTCxLSFM) to study glioma invasion	27
The perceived decline of “disruptive” science and technology	27
Differential roles of the fish chitinous membrane in gut barrier immunity and digestive compartments	27
Keep biology weird	27
Structural study of UFL1‐UFC1 interaction uncovers the role of UFL1 N‐terminal helix in ufmylation	27
The cancer microbiome	26
Estrogen receptor alpha signaling in dendritic cells modulates autoimmune disease phenotype in mice	26
The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties	26
Intracellular growth of Brucella is mediated by Dps‐dependent activation of ferritinophagy	26
Once in a lifetime	26
A trashed treasure	26
The taste of vitamin C in Drosophila	26
SARS‐CoV‐2‐related bat virus behavior in human‐relevant models sheds light on the origin of COVID‐19	26
Adult neural stem cells and neurogenesis are resilient to intermittent fasting	25
Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV	25
Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL‐1R/TLR signals	25
Cancer‐cell‐secreted extracellular vesicles target p53 to impair mitochondrial function in muscle	24
EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole	24
Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing	24
Metabolomics meets systems immunology	24
Lipin‐2 regulates the antiviral and anti‐inflammatory responses to interferon	24
Co‐evolution within the plant holobiont drives host performance	24
The obesity‐linked human lncRNA AATBC stimulates mitochondrial function in adipocytes	24
Myddosome clustering in IL‐1 receptor signaling regulates the formation of an NF‐kB activating signalosome	24
Candida albicans induces neutrophil extracellular traps and leucotoxic hypercitrullination via candidalysin	24