EMBO Reports

Article	Citations
Mitochondrial DNA in inflammation and immunity	415
Antibiotic resistance and persistence—Implications for human health and treatment perspectives	219
The evolving landscape around genome editing in agriculture	114
AI revolutions in biology	106
PINK 1 phosphorylates Drp1 S616 to regulate mitophagy‐independent mitochondrial dynamics	104
In‐depth and 3‐dimensional exploration of the budding yeast phosphoproteome	97
Ageing, metabolism and the intestine	89
RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss	79
The interplay between DNA and histone methylation: molecular mechanisms and disease implications	76
Rapid endotheliitis and vascular damage characterize SARS‐CoV‐2 infection in a human lung‐on‐chip model	76
Cell cycle dynamics of lamina‐associated DNA	71
The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity	69
Root endophyte induced plant thermotolerance by constitutive chromatin modification at heat stress memory gene loci	68
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development	67
Respiratory supercomplexes enhance electron transport by decreasing cytochrome c diffusion distance	66
SIRT 2‐dependent IDH 1 deacetylation inhibits colorectal cancer and liver metastases	65
SARS‐CoV‐2 evades immune detection in alveolar macrophages	64
Histone acetyltransferase 1 is a succinyltransferase for histones and non‐histones and promotes tumorigenesis	63
USP 1 deubiquitinates Akt to inhibit PI 3K‐Akt‐FoxO signaling in muscle during prolonged starvation	63
Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca 2+ ‐dependent death of cancer cells	60
Iron loss triggers mitophagy through induction of mitochondrial ferritin	60
Mitochondrial protein biogenesis in the synapse is supported by local translation	58
Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish	58
Fusobacterium nucleatum secretes amyloid‐like FadA to enhance pathogenicity	58
Healthy soils for healthy plants for healthy humans	57

Mitophagy receptor FUNDC1 is regulated by PGC‐1α/NRF1 to fine tune mitochondrial homeostasis	56
Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism	56
Mitochondrial transplantation—a possible therapeutic for mitochondrial dysfunction?	56
Transfer of LncRNA CRNDE in TAM‐derived exosomes is linked with cisplatin resistance in gastric cancer	56
ALIX and ceramide differentially control polarized small extracellular vesicle release from epithelial cells	55
The Arabidopsis lncRNA ASCO modulates the transcriptome through interaction with splicing factors	55
From deficit to dialogue in science communication	55
ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion	55
Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take	55
N(6)‐methyladenosine‐binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay	54
Prostate cancer cell‐intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone	54
Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER‐phagy, and Collagen quality control	53
Transcription factor CDF4 promotes leaf senescence and floral organ abscission by regulating abscisic acid and reactive oxygen species pathways in Arabidopsis	53
Epstein–Barr virus‐derived circular RNA LMP 2A induces stemness in EBV ‐associated gastric cancer	52
Systemic effects of mitochondrial stress	52
The 18S ribosomal RNA m 6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila	51
Exosome‐like nanoparticles from Mulberry bark prevent DSS‐induced colitis via the AhR/COPS8 pathway	51
Phospholipid transfer function of PTPIP51 at mitochondria‐associated ER membranes	50
Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance	49
Loss of TMEM 106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice	49
Fighting antibiotic resistance—strategies and (pre)clinical developments to find new antibacterials	48
Specific RNA interactions promote TDP‐43 multivalent phase separation and maintain liquid properties	48
Key phosphorylation sites in GPCR s orchestrate the contribution of β‐Arrestin 1 in ERK 1/2 activation	46
Fermentation for future food systems	45
Mentoring minority trainees	45
USP22 controls necroptosis by regulating receptor‐interacting protein kinase 3 ubiquitination	45
N‐glycosylation of PD‐1 promotes binding of camrelizumab	45
TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease	44
HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle‐resident mesenchymal cells	44
The long journey towards standards for engineering biosystems	44
Irgm2 and Gate‐16 cooperatively dampen Gram‐negative bacteria‐induced caspase‐11 response	43
Autoimmunity gene IRGM suppresses cGAS ‐ STING and RIG ‐I‐	43
Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease	42
The spread of the COVID ‐19 coronavirus	42
Glucose uptake to guard cells via STP transporters provides carbon sources for stomatal opening and plant growth	42
A malectin‐like receptor kinase regulates cell death and pattern‐triggered immunity in soybean	42
The 18S rRNA m 6 A methyltransferase METTL 5 promotes mouse embryonic stem cell differentiation	41
Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish	40
Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction	40
Putting the brakes on phagocytosis: “don't‐eat‐me” signaling in physiology and disease	40
Aneuploid senescent cells activate NF‐κB to promote their immune clearance by NK cells	40
NeutrobodyPlex—monitoring SARS‐CoV‐2 neutralizing immune responses using nanobodies	40
The mitochondrial Ca 2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis	39
Curcumin prevents obesity by targeting TRAF4‐induced ubiquitylation in m 6 A‐dependent manner	39
MAP kinase cascades in plant development and immune signaling	39
Dynamin‐related Irgm proteins modulate LPS‐induced caspase‐11 activation and septic shock	39
TLR4‐dependent shaping of the wound site by MSCs accelerates wound healing	39
KUP 9 maintains root meristem activity by regulating K + and auxin homeostasis in response to low K	39
Nanotube‐like processes facilitate material transfer between photoreceptors	39
Hsp90‐mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling	38

Nesprin‐2 accumulates at the front of the nucleus during confined cell migration	38
ECE2 regulates neurogenesis and neuronal migration during human cortical development	37
Remodeling and activation mechanisms of outer arm dyneins revealed by cryo‐EM	37
PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal‐to‐zygotic transition	37
The struggle of a good friend getting old: cellular senescence in viral responses and therapy	37
H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing	36
FAM111 protease activity undermines cellular fitness and is amplified by gain‐of‐function mutations in human disease	36
The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation	36
Myf6/MRF4 is a myogenic niche regulator required for the maintenance of the muscle stem cell pool	35
Loss of TMEM 106B potentiates lysosomal and FTLD ‐like pathology in progranulin‐deficient mice	35
Best practices to ensure robust investigation of circular RNAs: pitfalls and tips	35
Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures	35
Interferon‐induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20	35
The phyB‐dependent induction of HY5 promotes iron uptake by systemically activating FER expression	35
Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF	35
O‐glycan initiation directs distinct biological pathways and controls epithelial differentiation	34
GSDMD drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for NETosis	34
AP ‐2 reduces amyloidogenesis by promoting BACE 1 trafficking and degradation in neurons	34
MPK3/6‐induced degradation of ARR1/10/12 promotes salt tolerance in Arabidopsis	34
Succinylation of H3K122 destabilizes nucleosomes and enhances transcription	33
Alterations in mitochondrial morphology as a key driver of immunity and host defence	33
Nuclear envelope rupture and NET formation is driven by PKCα‐mediated lamin B disassembly	33
Fast news or fake news?	32
OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential	32
Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice	32
Calcium signaling induces a partial EMT	32
Monitoring mitochondrial translation in living cells	32
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth	32
ER ‐phagy: selective autophagy of the endoplasmic reticulum	31
PPARα alleviates iron overload‐induced ferroptosis in mouse liver	31
CTCF shapes chromatin structure and gene expression in health and disease	31
Chronic cold exposure enhances glucose oxidation in brown adipose tissue	31
Intellectual disability‐associated gene ftsj1 is responsible for 2′‐O‐methylation of specific tRNAs	31
Get closer and make hotspots: liquid–liquid phase separation in plants	30
Structure of RyR1 in native membranes	30
Phase‐separated foci of EML4‐ALK facilitate signalling and depend upon an active kinase conformation	30
A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection	30
Single‐cell analysis reveals dynamic changes of neural cells in developing human spinal cord	30
The FUS gene is dual‐coding with both proteins contributing to FUS ‐mediated toxicity	29
piRNA‐ and siRNA‐mediated transcriptional repression in Drosophila , mice, and yeast: new insights and biodiversity	29
PIDDosome‐induced p53‐dependent ploidy restriction facilitates hepatocarcinogenesis	28
TIFA has dual functions in Helicobacter pylori ‐induced classical and alternative NF‐κB pathways	28
High‐grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF‐1	28
Health disinformation & social media	27
20,000 picometers under the OMM: diving into the vastness of mitochondrial metabolite transport	27
Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling	27
Regulation and inhibition of the DNA sensor cGAS	27
Hippocampal CD 39/ ENTPD 1 promotes mouse depression‐like behavior through hydrolyzing extracellular ATP	27
Placensin is a glucogenic hormone secreted by human placenta	27
Trigger factor is a bona fide secretory pathway chaperone that interacts with SecB and the translocase	27
Mitochondrial F 1 F O ATP synthase determines the local proton motive force at cristae rims	27
The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT –liver communication	27
Redox activation of ATM enhances GSNOR translation to sustain mitophagy and tolerance to oxidative stress	27
Bardet–Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self‐tolerance	27
The stress granule protein G3BP1 promotes pre‐condensation of cGAS to allow rapid responses to DNA	27
SFRP1 modulates astrocyte‐to‐microglia crosstalk in acute and chronic neuroinflammation	26
Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development	26
Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice	26
Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1	26
Histone methyltransferase DOT1L controls state‐specific identity during B cell differentiation	26
Homologous recombination and Mus81 promote replication completion in response to replication fork blockage	26
Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons	26
USP42 protects ZNRF3/RNF43 from R‐spondin‐dependent clearance and inhibits Wnt signalling	26
Maintaining proteostasis under mechanical stress	26
Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development	26
Alternative splicing coupled mRNA decay shapes the temperature‐dependent transcriptome	26
The ubiquitin ligation machinery in the defense against bacterial pathogens	26
COVID ‐19 and misinformation	26
Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA	26
Linking transport and translation of mRNAs with endosomes and mitochondria	26
The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder	26
Transient Dux expression facilitates nuclear transfer and induced pluripotent stem cell reprogramming	26
BioID reveals an ATG9A interaction with ATG13‐ATG101 in the degradation of p62/SQSTM1‐ubiquitin clusters	26
CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage	25
Small‐molecule inhibition of aging‐associated chromosomal instability delays cellular senescence	25
Quaking 5 suppresses TGF‐β‐induced EMT and cell invasion in lung adenocarcinoma	25
Micro RNA ‐195 controls MICU 1 expression and tumor growth in ovarian cancer	25
Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole	25
m6A methylation promotes white‐to‐beige fat transition by facilitating Hif1a translation	25
Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia	25

Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming	25
Biparatopic sybodies neutralize SARS‐CoV‐2 variants of concern and mitigate drug resistance	25
VEGF‐B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content	24
Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast	24
HOTAIR lncRNA promotes epithelial–mesenchymal transition by redistributing LSD1 at regulatory chromatin regions	24
Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates	24
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1	24
lncRNA‐encoded pep‐AP attenuates the pentose phosphate pathway and sensitizes colorectal cancer cells to Oxaliplatin	24
TET 2 promotes anti‐tumor immunity by governing G‐ MDSC s and CD 8 + T‐c	24
Atg1 kinase regulates autophagosome‐vacuole fusion by controlling SNARE bundling	24
Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains	24
CUL2LRR1, TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle	24
A one‐carbon path for fixing CO 2	24
Calcium regulation of stem cells	24
A multifaceted cellular damage repair and prevention pathway promotes high‐level tolerance to β‐lactam antibiotics	23
Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity	23
So close, no matter how far: multiple paths connecting transcription to mRNA translation in eukaryotes	23
TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution	23
HMCES safeguards replication from oxidative stress and ensures error‐free repair	23
Plasmodium transcription repressor AP2‐O3 regulates sex‐specific identity of gene expression in female gametocytes	23
Mild mitochondrial impairment enhances innate immunity and longevity through ATFS‐1 and p38 signaling	23
Deubiquitinating enzymes UBP12 and UBP13 stabilize the brassinosteroid receptor BRI1	23
Single‐cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland	23
Amyloid aggregates accumulate in melanoma metastasis modulating YAP activity	23
TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment	23
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1	23
Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity	22
SGTA associates with nascent membrane protein precursors	22
Protein phosphatase PP2A regulates microtubule orientation and dendrite pruning in Drosophila	22
Actin filament oxidation by MICAL1 suppresses protections from cofilin‐induced disassembly	22
Exploring GPCR‐arrestin interfaces with genetically encoded crosslinkers	22
Lipoic acid rejuvenates aged intestinal stem cells by preventing age‐associated endosome reduction	22
DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging	22
B1‐type cyclins control microtubule organization during cell division in Arabidopsis	22
Modelling of primary ciliary dyskinesia using patient‐derived airway organoids	22
MOAP‐1‐mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling	22
Influenza A viruses limit NLRP3‐NEK7‐complex formation and pyroptosis in human macrophages	22
ALS ‐linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain‐of‐function	21
Mobile late endosomes modulate peripheral endoplasmic reticulum network architecture	21
Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere	21
CDK inhibitor Palbociclib targets STING to alleviate autoinflammation	21
IKKβ is required for the formation of the NLRP3 inflammasome	21
EphA2 phosphorylates NLRP 3 and inhibits inflammasomes in airway epithelial cells	21
MYC promotes cancer progression by modulating m6A modifications to suppress target gene translation	21
Emerging pathogen evolution	21
PLETHORA‐WOX5 interaction and subnuclear localization control Arabidopsis root stem cell maintenance	21
PML‐NB‐dependent type I interferon memory results in a restricted form of HSV latency	21
PDS 5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis	21
Differential regulation of glycinergic and GABAergic nanocolumns at mixed inhibitory synapses	21
MiR‐342 controls Mycobacterium tuberculosis susceptibility by modulating inflammation and cell death	21
N ‐acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages	21
Non‐redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression	21
Degradation of WTAP blocks antiviral responses by reducing the m 6 A levels of IRF3 and IFNAR1 mRNA	20
Gi‐coupled receptor activation potentiates Piezo2 currents via Gβγ	20
Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation	20
Molecular networks of the FOXP2 transcription factor in the brain	20
Nitrate triggered phosphoproteome changes and a PIN2 phosphosite modulating root system architecture	20
Dynamics of Staphylococcus aureus Cas9 in DNA target Association and Dissociation	20
FAM111A induces nuclear dysfunction in disease and viral restriction	20
Biodiversity crisis or sixth mass extinction?	20
The power of saying no	20
Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters	20
Neuronal lipolysis participates in PUFA‐mediated neural function and neurodegeneration	20
HP1 maintains protein stability of H3K9 methyltransferases and demethylases	20
Toll‐like receptor 4 is activated by platinum and contributes to cisplatin‐induced ototoxicity	20
PP2A phosphatase is required for dendrite pruning via actin regulation in Drosophila	20
Quorum sensing governs a transmissive Legionella subpopulation at the pathogen vacuole periphery	20
A cell atlas of adult muscle precursors uncovers early events in fibre‐type divergence in Drosophila	20
Non‐apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence	20
A common molecular mechanism underlies the role of Mps1 in chromosome biorientation and the spindle assembly checkpoint	20
The unfolded protein response links tumor aneuploidy to local immune dysregulation	20
MITOL promotes cell survival by degrading Parkin during mitophagy	20
TMBIM5 is the Ca 2+ /H + antiporter of mammalian mitochondria	19
MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking	19
SMaRT lncRNA controls translation of a G‐quadruplex‐containing mRNA antagonizing the DHX36 helicase	19
Muscle‐derived exophers promote reproductive fitness	19
From the freezer to the clinic	19
Modulation of phagosome phosphoinositide dynamics by a Legionella phosphoinositide 3‐kinase	19
Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness	19
Pseudomonas aeruginosa survives in epithelia by ExoS‐mediated inhibition of autophagy and mTOR	19
LGR 5 controls extracellular matrix production by stem cells in the developing intestine	19
Long non‐coding RNA TINCR suppresses metastatic melanoma dissemination by preventing ATF4 translation	19
PLK1 regulates centrosome migration and spindle dynamics in male mouse meiosis	19
N‐acetyl‐l‐tyrosine is an intrinsic triggering factor of mitohormesis in stressed animals	19
Pseudo‐repeats in doublecortin make distinct mechanistic contributions to microtubule regulation	19
PEBP 1 suppresses HIV transcription and induces latency by inactivating MAPK / NF	19
βH‐spectrin is required for ratcheting apical pulsatile constrictions during tissue invagination	19
Long non‐coding RNA ELDR enhances oral cancer growth by promoting ILF3‐cyclin E1 signaling	19
Iron‐induced NCOA4 condensation regulates ferritin fate and iron homeostasis	19
Function of the SNARE Ykt6 on autophagosomes requires the Dsl1 complex and the Atg1 kinase complex	19
The actin modulator hMENA regulates GAS 6‐ AXL axis and pro‐tumor cancer/stromal cell cooperati	19
Using a bistable animal opsin for switchable and scalable optogenetic inhibition of neurons	19
Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells	19
ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids	19
Glial Hedgehog signalling and lipid metabolism regulate neural stem cell proliferation in Drosophila	18