Nature Cell Biology

Article	Citations
STING and fat crosstalk	635
TRIM8 in Ewing sarcoma	420
Force boosts SARS-CoV-2 invasion	350
Enhancing T cell therapy	325
Pushing chromatin to totipotency	267
Restoring placental methylome	213
Unravelling the endoplasmic reticulum–Golgi intermediate compartment in plant cells	211
Keeping membraneless organelles apart	181
tRNA flux and consistency in differentiation	171
Immune memory in individuals with COVID-19	164
An inflammatory switch for stem cell plasticity	159
COPIng with senescence	157
The guinea pig serves as an alternative model to study human preimplantation development	153
Finding a chaperone for TDP-43	148
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription	136
Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity	133
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication	129
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis	128
RIPK1 and RIPK3 form mosaic necrosomes	125
ER-associated RNA silencing promotes ER quality control	125
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources	123
Compression-dependent microtubule reinforcement enables cells to navigate confined environments	120
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture	118
A guideline on the molecular ecosystem regulating ferroptosis	117
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage	116

Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ	113
Telomere dysfunction in ageing and age-related diseases	112
Criteria for the standardization of stem-cell-based embryo models	110
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function	109
Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1	106
A serendipitous discovery of a family of membrane remodelling proteins	106
Implementing sustainable science in the lab	106
Regenerating the academic pipeline	104
Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer	101
How a ribosomal protein avoids mixed signals	101
Nuclear class 3 PI3K coactivates circadian clock	100
Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements	98
Real-time and programmable transcriptome sequencing with PROFIT-seq	95
Publisher Correction: p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth	95
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	95
Spermidine is essential for fasting-mediated autophagy and longevity	92
The mechanics of crypt morphogenesis	92
PRC2 shields the potency of human stem cells	91
HSF1 renders NK cells too stressed to respond	90
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise	90
Membranes regulate biomolecular condensates	87
Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth	87
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation	87
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration	86
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	85
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates	84
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis	81
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis	81
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells	81
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer	80
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription	80
TCF3, TCF12 and distinct enhancers regulate oocyte transcription	78
A cell biological perspective on Singapore’s scientific growth	77
Sequential enhancer state remodelling defines human germline competence and specification	77
Time for lipid cell biology	77
Deep-learning for microscopy	77
Xist seeds X inactivation	77
Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs	76
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system	75
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling	75
Tissue memory relies on stem cell priming in distal undamaged areas	75
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome	73
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells	72
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification	71
Mapping the foetal striatum	71
Telomeres are a life-extending gift	71
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor	71
It started with a western	70
Waste management and cell death in T cells	67
Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning	67

Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells	67
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth	66
The role of PINK1–Parkin in mitochondrial quality control	65
Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker	65
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities	64
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition	64
Surveying the dividing genome	63
The transcription factor GABPA is a master regulator of naive pluripotency	63
Single-cell spatial transcriptomics	63
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness	62
Publisher Correction: Epithelial cell plasticity drives endoderm formation during gastrulation	62
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions	60
ASTE1 cutting to block DNA end resection	60
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity	59
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope	59
Phase separation of EB1 guides microtubule plus-end dynamics	58
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair	58
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming	57
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes	57
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair	56
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool	56
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance	56
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity	56
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development	56
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	56
Cell-intrinsic and microenvironmental determinants of metastatic colonization	56
CAF heterogeneity and dynamics	55
Keeping up with the Rag GTPases	54
Golden opportunity for piRNA in female fertility	52
Author Correction: Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants	52
Author Correction: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation	52
Author Correction: Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	52
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing	52
Publisher Correction: m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	51
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma	51
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis	51
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions	50
Lysate-based pipeline to characterize microtubule-associated proteins uncovers unique microtubule behaviours	50
Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells	50
Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis	50
Non-invasive and high-throughput interrogation of exon-specific isoform expression	50
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division	50
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis	50
Multiplexed genome regulation in vivo with hyper-efficient Cas12a	49
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy	49
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation	48
The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels	48
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes	48
Cell type ontologies of the Human Cell Atlas	48
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung	48
Conference accessibility should be a universal concern	47
A milestone in epithelial–mesenchymal transition	47
Species-specific cortex features	47
Mitochondrial YME1L1 governs unoccupied protein translocase channels	47
Rear traction forces drive adherent tissue migration in vivo	47
A single-cell transcriptomic landscape of the lungs of patients with COVID-19	47
From phage genetics to chromosomes as mechanical objects	46
Publisher Correction: POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis	46
COVID-19 lung atlas	46
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression	46
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression	46
A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling	46
Mapping T cell landscapes in B cell lymphomas	46
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth	45
Dissecting melanocytes to predict melanoma	45
Spatial transcriptomic characterization of a Carnegie stage 7 human embryo	45
Long life depends on open communication	44
Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma	44
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion	44
Cell origin of BRCA2-mutant breast cancer	44
Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities	43
VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells	43
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels	43
The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming	43
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination	42
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	42
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT	41
Mapping paths through the nuclear pore complex	41
Harnessing introns to monitor gene expression	41
Diet and longevity	41

Ribophagy relies on Rpl12	41
Worrying through the ECM	40
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling	39
Navigating human embryogenesis through tailored model selection	39
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases	39
Author Correction: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	39
An expanding repertoire of E3 ligases in membrane Atg8ylation	39
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition	38
Arginyl-tRNA synthetase in inflammation	38
RNA sequestration in P-bodies sustains myeloid leukaemia	38
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation	38
Author Correction: Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly	38
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis	37
NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency	37
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis	37
In situ architecture of the human prohibitin complex	37
Metabolites in tumour interstitial fluid directly suppress T cells	37
Evidence for widespread cytoplasmic structuring into mesoscale condensates	37
Author Correction: Stiff matrix induces exosome secretion to promote tumour growth	36
Lipidomes define immune cell identity	36
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	36
FUS maintains TAZ fluidity and function	36
Stiff matrix induces exosome secretion to promote tumour growth	36
Modelling SARS-CoV-2 CNS infection	36
The spectrin cytoskeleton integrates endothelial mechanoresponses	36
METTL3 restrains autoimmunity in β-cells	36
Order and disorder in clathrin-mediated endocytosis	36
Pausing pluripotency via RNA methylation	35
Mitochondrial shape alteration by metabolites	35
Nuclear pores safeguard the integrity of the nuclear envelope	35
A chosen STING with a PERKy trail	35
Breaking up translation condensates in cancer	35
Intrinsically disordered CO2 sensors	35
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes	35
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability	34
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection	34
CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development	34
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation	34
Ex vivo imaging reveals the spatiotemporal control of ovulation	33
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity	33
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression	33
Celebrating 25 years of cell biology	33
Neutrophil-derived migrasomes are an essential part of the coagulation system	32
Human neural tube morphogenesis in a dish	32
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers	32
Lysosome lipid signalling from the periphery to neurons regulates longevity	32
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos	32
Softening redox homeostasis in cancer cells	31
Sperm bud mitochondria to adjust the numbers	31
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase	31
A new cell in an old tactile sensory organ	31
Boosting cargo turnover with receptor mobility	31
Gender equity: toward redefining values	31
FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance	30
Harnessing lysohormesis for healthy ageing	30
Sugar unmasking for trafficking	30
Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants	30
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing	30
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability	30
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules	30
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites	29
Combinatorial selective ER-phagy remodels the ER during neurogenesis	29
NAD+ regulates nucleotide metabolism and genomic DNA replication	29
RNA scaffolds the Golgi ribbon by forming condensates with GM130	29
Generic nature of the condensed states of proteins	29
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation	29
Retinoic acid induces human gastruloids with posterior embryo-like structures	29
How cell biology can save the planet	28
Biases in machine-learning models of human single-cell data	28
Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan	28
Lessons from infrastructure and research advocacy in India	28
PTEN checkMAITs type-17 innate-like T cells	27
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics	27
Eosinophil extracellular traps drive asthma progression through neuro-immune signals	27
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation	27
NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling	27
Cohesin regulates homology search during recombinational DNA repair	27
Now is the greatest time to be in it	27
A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts	27
ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels	26
CLICing on endocytic cargoes for cancer invasion	26
Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis	26
Host protection by two memory-like MAIT subsets	26
RETRACTED ARTICLE: CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling	26
Stem cell progeny liaisons in regeneration	26
Publisher Correction: o8G modifications rewire tumoral microRNAs	26
Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome	26
Profiling cell death in COVID-19 pathology	26
Author Correction: Defining E3 ligase–substrate relationships through multiplex CRISPR screening	26
Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns	26
Architecture and dynamics of a desmosome–endoplasmic reticulum complex	25
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila	25
Deadly actin collapse by disulfidptosis	25
Temporal and spatial topography of cell proliferation in cancer	25
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis	25