Nature Cell Biology

Article	Citations
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis	536
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis	361
Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis	321
Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture	253
SIRT1 is downregulated by autophagy in senescence and ageing	248
Telomere dysfunction in ageing and age-related diseases	247
Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker	238
Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression	229
PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis	229
Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion	223
CRISPR technologies for precise epigenome editing	218
Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy	206
Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling	197
Nucleated transcriptional condensates amplify gene expression	194
Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	187
Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity	174
Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma	161
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis	156
Cellular and molecular architecture of the intestinal stem cell niche	135
ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration	132
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury	131
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control	125
PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications	125
Evaluating totipotency using criteria of increasing stringency	125
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells	123

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration	121
Liquid-like protein interactions catalyse assembly of endocytic vesicles	117
Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity	115
Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis	113
R-loops as Janus-faced modulators of DNA repair	106
UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination	106
A single-cell transcriptomic landscape of the lungs of patients with COVID-19	104
Autophagosome biogenesis comes out of the black box	104
Cell fate coordinates mechano-osmotic forces in intestinal crypt formation	104
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression	103
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis	102
Generic nature of the condensed states of proteins	102
The STING phase-separator suppresses innate immune signalling	102
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA	99
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis	98
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age	98
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation	97
Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses	96
Phase separation of SERRATE drives dicing body assembly and promotes miRNA processing in Arabidopsis	96
LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy	95
Depletion of aneuploid cells in human embryos and gastruloids	95
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells	92
Metabolic communication in the tumour–immune microenvironment	91
Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress	91
The chromatin remodeler DDM1 prevents transposon mobility through deposition of histone variant H2A.W	87
m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype	85
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance	83
Exploring the expanding universe of small RNAs	81
Membrane surfaces regulate assembly of ribonucleoprotein condensates	80
Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses	79
Mechanical force application to the nucleus regulates nucleocytoplasmic transport	79
METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis	77
STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury	77
TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis	77
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin	77
An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer	76
p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth	76
Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling	76
Cell type ontologies of the Human Cell Atlas	75
Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish	73
Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation	72
Anatomical structures, cell types and biomarkers of the Human Reference Atlas	72
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis	72
Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock	71
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung	70
Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19	68
Control of endothelial quiescence by FOXO-regulated metabolites	67
Proteotoxic stress is a driver of the loser status and cell competition	67
Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development	66
POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis	66

A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression	65
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia	64
Human melanocyte development and melanoma dedifferentiation at single-cell resolution	64
Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis	63
Stiff matrix induces exosome secretion to promote tumour growth	63
A PRC2-independent function for EZH2 in regulating rRNA 2′-O methylation and IRES-dependent translation	62
Spatial organization of transcribed eukaryotic genes	60
Heat stress activates YAP/TAZ to induce the heat shock transcriptome	59
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes	59
The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels	59
Nucleotide imbalance decouples cell growth from cell proliferation	59
Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning	58
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing	58
An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory	56
SMN-primed ribosomes modulate the translation of transcripts related to spinal muscular atrophy	56
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	56
Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens	56
Functional mechanisms and abnormalities of the nuclear lamina	56
Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome	55
Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility	55
Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation	54
Deadly actin collapse by disulfidptosis	54
Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations	53
Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition	52
The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin	52
Metabolic determination of cell fate through selective inheritance of mitochondria	51
Epithelial cell plasticity drives endoderm formation during gastrulation	51
Cell cycle-specific phase separation regulated by protein charge blockiness	51
Eosinophil extracellular traps drive asthma progression through neuro-immune signals	51
Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues	51
Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks	50
The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming	50
Recycling of autophagosomal components from autolysosomes by the recycler complex	50
Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates	49
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	49
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2	49
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability	48
Multiplexed genome regulation in vivo with hyper-efficient Cas12a	48
Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration	47
Phosphatidylinositol 3-kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4	47
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling	47
Illuminating RNA biology through imaging	46
Single-cell atlas of human liver development reveals pathways directing hepatic cell fates	46
Cohesin regulates homology search during recombinational DNA repair	45
Global profiling of RNA-binding protein target sites by LACE-seq	45
ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation	45
A reversible shearing DNA probe for visualizing mechanically strong receptors in living cells	45
The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells	45
Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain	44
CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling	44
Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea	44
Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration	44
Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death	44
Dissecting OCT4 defines the role of nucleosome binding in pluripotency	43
ATG9A protects the plasma membrane from programmed and incidental permeabilization	43
Monocytes deposit migrasomes to promote embryonic angiogenesis	43
Untangling the web of intratumour heterogeneity	42
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth	42
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function	42
E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis	42
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics	42
LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy	41
A guide to naming eukaryotic circular RNAs	41
Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth	40
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity	40
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation	40
A single-cell transcriptome atlas profiles early organogenesis in human embryos	39
Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases	39
Rear traction forces drive adherent tissue migration in vivo	39
Mammalian genome innovation through transposon domestication	39
Opportunities and challenges in studying the extracellular vesicle corona	38
Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements	38
A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers	38
Temporal and spatial topography of cell proliferation in cancer	38
Dynamin-dependent vesicle twist at the final stage of clathrin-mediated endocytosis	38
Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechanosensitive structures	38
Identification of two pathways mediating protein targeting from ER to lipid droplets	38
A p53–phosphoinositide signalosome regulates nuclear AKT activation	37
Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence	37
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence	37

LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria	37
Phase separation of EB1 guides microtubule plus-end dynamics	37
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair	36
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)	36
Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids	36
Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction	36
Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly	36
Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis	36
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition	36
Reciprocal regulation of chaperone-mediated autophagy and the circadian clock	35
Substoichiometric action of long noncoding RNAs	35
Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage	35
Lysosome lipid signalling from the periphery to neurons regulates longevity	35
The piRNA pathway is essential for generating functional oocytes in golden hamsters	35
A transitional stem cell state in the lung	35
Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs	35
Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis	35
Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions	35
Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis	35
CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells	35
YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis	34
Apoptosis in the fetal testis eliminates developmentally defective germ cell clones	34
A biomechanical switch regulates the transition towards homeostasis in oesophageal epithelium	34
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination	34
Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension	34
Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters	34
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage	34
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics	33
Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration	33
The spectrin cytoskeleton integrates endothelial mechanoresponses	32
Sequential enhancer state remodelling defines human germline competence and specification	32
Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration	32
Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells	32
Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells	31
METALIC reveals interorganelle lipid flux in live cells by enzymatic mass tagging	31
Stalled replication fork protection limits cGAS–STING and P-body-dependent innate immune signalling	31
Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space	31
ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection	31
dCas9-based gene editing for cleavage-free genomic knock-in of long sequences	31
Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer	30
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	30
Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation	30
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells	30
Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors	30
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation	30
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness	29
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer	29
LKB1 inactivation modulates chromatin accessibility to drive metastatic progression	29
Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis	29
The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis	29
Super-resolved 3D tracking of cargo transport through nuclear pore complexes	29
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity	28
Proton-gated anion transport governs macropinosome shrinkage	28
53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis	28
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool	28
Publisher Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation	27
Lysate-based pipeline to characterize microtubule-associated proteins uncovers unique microtubule behaviours	27
Optogenetic manipulation of cellular communication using engineered myosin motors	27
Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma	26
A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	26
CDK1–cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry	26
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities	26
Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis	25
Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection	25
Monocyte and dendritic cell defects in COVID-19	25
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence	25
Synthetic immunomodulation with a CRISPR super-repressor in vivo	25
Perinatal angiogenesis from pre-existing coronary vessels via DLL4–NOTCH1 signalling	25
The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1	25
Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic cell development	25
Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors	25