Nature Cell Biology

Article	Citations
Unravelling the endoplasmic reticulum–Golgi intermediate compartment in plant cells	942
Keeping membraneless organelles apart	343
tRNA flux and consistency in differentiation	329
COPIng with senescence	296
Restoring placental methylome	227
Designing protein-based artificial kinetochores as decoys to prevent meiotic errors in oocytes	227
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells	221
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis	211
Finding a chaperone for TDP-43	185
Atlas of amnion development during the first trimester of human pregnancy	184
Reinvigorating COTL1high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours	183
Dynein upsizes under load	179
Ectosomes step forward in α-synuclein spread	175
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage	168
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication	165
Criteria for the standardization of stem-cell-based embryo models	161
ER-associated RNA silencing promotes ER quality control	160
Compression-dependent microtubule reinforcement enables cells to navigate confined environments	158
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription	158
The guinea pig serves as an alternative model to study human preimplantation development	156
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture	146
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function	143
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ	136
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources	134
A guideline on the molecular ecosystem regulating ferroptosis	131

Regenerating the academic pipeline	130
How a ribosomal protein avoids mixed signals	130
A serendipitous discovery of a family of membrane remodelling proteins	129
Implementing sustainable science in the lab	127
Nuclear class 3 PI3K coactivates circadian clock	127
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells	126
PRC2 shields the potency of human stem cells	125
HSF1 renders NK cells too stressed to respond	123
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death	122
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	120
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate	120
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer	119
Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth	114
A lysosomal surveillance response to stress extends healthspan	113
TCF3, TCF12 and distinct enhancers regulate oocyte transcription	108
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis	105
Mitoxyperilysis as a distinct cell death type	105
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation	103
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise	97
Acidic niche sugar shield blocks ferroptosis	95
Real-time and programmable transcriptome sequencing with PROFIT-seq	91
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates	90
Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1	89
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis	88
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	88
Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer	86
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription	86
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration	86
A cell biological perspective on Singapore’s scientific growth	86
Spermidine is essential for fasting-mediated autophagy and longevity	86
A model for propagation of RNA structural memory through biomolecular condensates	83
Waste management and cell death in T cells	83
Deep-learning for microscopy	82
It started with a western	82
Tissue memory relies on stem cell priming in distal undamaged areas	82
Telomeres are a life-extending gift	78
Assessing gene loss after gene editing	78
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition	77
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor	77
Time for lipid cell biology	77
Escape from X inactivation is directly modulated by Xist noncoding RNA	77
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system	77
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells	77
Fat bolsters tumours against ferroptosis	76
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome	76
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities	76
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth	76
The role of PINK1–Parkin in mitochondrial quality control	75
Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs	75
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification	72

Zippering against the beat	71
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope	70
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness	70
Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment	70
The transcription factor GABPA is a master regulator of naive pluripotency	69
p53 increases phospholipid headgroup scavenging in senescence	69
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development	68
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity	67
Publisher Correction: SLC2A1+ tumour-associated macrophages spatially control CD8+ T cell function and drive resistance to immunotherapy in non-small-cell lung cancer	67
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming	66
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity	66
Cellular mechanisms of brain lipid metabolism in health and disease	66
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes	65
Cell-intrinsic and microenvironmental determinants of metastatic colonization	64
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair	64
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions	64
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool	63
Phase separation of EB1 guides microtubule plus-end dynamics	63
Programmed mitophagy at the oocyte-to-zygote transition promotes lineage endurance	62
Aberrant amino acid-sensing promotes immunotherapy resistance via the inflammatory cytokine–ZBTB5–mTORC1 axis	62
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	61
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis	61
A foundation for tomorrow’s discoveries in cell biology	61
Keeping up with the Rag GTPases	61
Author Correction: Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants	60
Author Correction: Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	60
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma	59
CoCo-ST detects global and local biological structures in spatial transcriptomics datasets	59
Publisher Correction: m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	59
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung	59
A guide to using embedded ethics in human stem-cell-based embryo model research	58
Proximal proteomics reveals a landscape of human nuclear condensates	58
Active size control of condensates by a kinase-based mechanism	58
The molecular basis of human transcription-coupled DNA repair	57
A milestone in epithelial–mesenchymal transition	57
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy	57
CAF heterogeneity and dynamics	57
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis	57
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes	56
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division	56
Mitochondrial YME1L1 governs unoccupied protein translocase channels	55
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux	55
DNA nanodevices detect an acidic nanolayer on the lysosomal surface	55
Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis	55
Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma	55
Young secretory proteins go through a phase	55
Revealing the order of chromatin reorganization events with Dam&ChIC	55
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing	54
Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1	54
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions	54
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression	53
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis	53
Autophagy-targeted NBR1–p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH	53
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation	53
Mapping T cell landscapes in B cell lymphomas	52
From phage genetics to chromosomes as mechanical objects	52
Conference accessibility should be a universal concern	52
Author Correction: Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development	51
Cell origin of BRCA2-mutant breast cancer	51
Long life depends on open communication	51
Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis	51
Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction	50
Spatial transcriptomic characterization of a Carnegie stage 7 human embryo	50
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression	50
A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling	50
Modelling co-development between the somites and neural tube in human trunk-like structures	50
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT	49
Cancer-associated fibroblasts regulate DNA repair in pancreatic cancer through NDRG1-mediated R-loop processing	49
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	49
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells	49
ERCC6L2–CtIP condensation tunes end resection	49
Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities	49
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth	49
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels	48
Shaping the composition of the mitochondrial outer membrane	48
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion	48
The proteomic landscape and temporal dynamics of human and mouse gastruloid development	48
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis	48
A bridge-like lipid transport protein controls plasma membrane lipid composition and fluidity	47
Worrying through the ECM	47

The glutathione S-transferase Gstt1 drives survival and dissemination in metastases	47
From fallout to renewal	47
Diet and longevity	47
Cracking glioblastoma core regulatory codes	47
Arginyl-tRNA synthetase in inflammation	47
Evidence for widespread cytoplasmic structuring into mesoscale condensates	46
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis	46
Visualizing suborganellar lipid distribution using correlative light and electron microscopy	46
Navigating human embryogenesis through tailored model selection	46
Target cell cortical tension regulates macrophage trogocytosis	45
Author Correction: Stiff matrix induces exosome secretion to promote tumour growth	44
CD160 dictates anti-PD-1 immunotherapy resistance by regulating CD8+ T cell exhaustion in colorectal cancer	44
Author Correction: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	44
Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis	44
The spectrin cytoskeleton integrates endothelial mechanoresponses	44
Metabolites in tumour interstitial fluid directly suppress T cells	44
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling	44
An expanding repertoire of E3 ligases in membrane Atg8ylation	43
Ribophagy relies on Rpl12	43
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	43
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier	43
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis	43
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation	43
RNA sequestration in P-bodies sustains myeloid leukaemia	42
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition	42
Stiff matrix induces exosome secretion to promote tumour growth	42
Harnessing introns to monitor gene expression	41
Nuclear mechanics as a determinant of nuclear pore complex plasticity	41
In situ architecture of the human prohibitin complex	41
Order and disorder in clathrin-mediated endocytosis	41
FUS maintains TAZ fluidity and function	40
Pausing pluripotency via RNA methylation	40
METTL3 restrains autoimmunity in β-cells	40
Intrinsically disordered CO2 sensors	40
Author Correction: SERRATE drives phase separation behaviours to regulate m6A modification and miRNA biogenesis	39
Crossover patterning through condensation and coarsening of pro-crossover factors	39
Neutrophil-derived migrasomes are an essential part of the coagulation system	39
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos	39
Ex vivo imaging reveals the spatiotemporal control of ovulation	38
A chosen STING with a PERKy trail	38
A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures	38
Lysosome lipid signalling from the periphery to neurons regulates longevity	38
Nuclear pores safeguard the integrity of the nuclear envelope	38
RNA-specific local translation is patterned by condensates for multinucleate cell growth	38
Morula-derived trophectoderm stem cells	38
Forcing cell fate	37
Programmable macromolecule delivery via engineered trogocytosis	37
Celebrating 25 years of cell biology	37
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation	37
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers	37
Lipidomes define immune cell identity	37
Remote control of AMPK via extracellular adenosine controls tissue growth	36
Boosting cargo turnover with receptor mobility	36
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection	36
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes	36
Sugar unmasking for trafficking	36
Breaking up translation condensates in cancer	36
Sperm bud mitochondria to adjust the numbers	36
A new cell in an old tactile sensory organ	36
Sperm miRNAs exercise benefits	35
RNA-binding proteins pull in chromatin loops	35
NAD+ regulates nucleotide metabolism and genomic DNA replication	35
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules	35
Role of vinculin in metabolism	35
Gender equity: toward redefining values	35
Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma	34
A comprehensive tRNA pseudouridine map uncovers targets dependent on human stand-alone pseudouridine synthases	34
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing	34
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability	34
Combinatorial selective ER-phagy remodels the ER during neurogenesis	34
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins	34
Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability	34
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites	33
Lessons from infrastructure and research advocacy in India	33
RNA scaffolds the Golgi ribbon by forming condensates with GM130	33
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation	33
Retinoic acid induces human gastruloids with posterior embryo-like structures	33
Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants	33
Harnessing lysohormesis for healthy ageing	33
Host protection by two memory-like MAIT subsets	33
PTEN checkMAITs type-17 innate-like T cells	32
Profiling cell death in COVID-19 pathology	32
Grow up, beta cells	32
Now is the greatest time to be in it	32
Cytoplasmic control of spindle architecture	32
Deciphering glioma susceptibility	31
Publisher Correction: o8G modifications rewire tumoral microRNAs	31
LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8	31
Stress response regulates cancer fibroblasts	31
Disulfidptosis meets antitumour immunity	31
Author Correction: Defining E3 ligase–substrate relationships through multiplex CRISPR screening	31
Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis	31
Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan	31
NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling	31
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation	30