Nature Cell Biology

Article	Citations
Unravelling the endoplasmic reticulum–Golgi intermediate compartment in plant cells	971
Keeping membraneless organelles apart	364
tRNA flux and consistency in differentiation	358
COPIng with senescence	302
Restoring placental methylome	233
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells	230
Finding a chaperone for TDP-43	218
Dynein upsizes under load	202
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription	191
The guinea pig serves as an alternative model to study human preimplantation development	190
Criteria for the standardization of stem-cell-based embryo models	183
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication	181
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis	179
Designing protein-based artificial kinetochores as decoys to prevent meiotic errors in oocytes	170
Reinvigorating COTL1high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours	170
Ectosomes step forward in α-synuclein spread	164
Atlas of amnion development during the first trimester of human pregnancy	163
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture	158
ER-associated RNA silencing promotes ER quality control	158
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ	147
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function	146
Compression-dependent microtubule reinforcement enables cells to navigate confined environments	145
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources	138
How a ribosomal protein avoids mixed signals	136
A guideline on the molecular ecosystem regulating ferroptosis	136

Regenerating the academic pipeline	133
A serendipitous discovery of a family of membrane remodelling proteins	133
Implementing sustainable science in the lab	132
PRC2 shields the potency of human stem cells	131
HSF1 renders NK cells too stressed to respond	130
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription	128
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells	126
Nuclear class 3 PI3K coactivates circadian clock	124
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death	123
Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer	123
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer	116
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate	114
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration	110
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation	105
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis	105
Acidic niche sugar shield blocks ferroptosis	100
Real-time and programmable transcriptome sequencing with PROFIT-seq	94
Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1	92
Mitoxyperilysis as a distinct cell death type	91
Mechanisms and functions of large extracellular vesicle biogenesis	90
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	89
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	89
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise	88
Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth	87
TCF3, TCF12 and distinct enhancers regulate oocyte transcription	87
A lysosomal surveillance response to stress extends healthspan	86
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates	85
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis	84
A cell biological perspective on Singapore’s scientific growth	83
Spermidine is essential for fasting-mediated autophagy and longevity	83
Waste management and cell death in T cells	82
Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs	81
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification	81
It started with a western	81
Assessing gene loss after gene editing	80
Deep-learning for microscopy	80
Telomeres are a life-extending gift	80
A model for propagation of RNA structural memory through biomolecular condensates	79
Fat bolsters tumours against ferroptosis	79
Time for lipid cell biology	79
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities	78
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth	78
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome	77
Tissue memory relies on stem cell priming in distal undamaged areas	77
Escape from X inactivation is directly modulated by Xist noncoding RNA	75
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells	74
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor	72
Zippering against the beat	72
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system	72
The role of PINK1–Parkin in mitochondrial quality control	72

Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness	71
p53 increases phospholipid headgroup scavenging in senescence	71
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair	69
Publisher Correction: SLC2A1+ tumour-associated macrophages spatially control CD8+ T cell function and drive resistance to immunotherapy in non-small-cell lung cancer	69
Phase separation of EB1 guides microtubule plus-end dynamics	68
Cellular mechanisms of brain lipid metabolism in health and disease	68
Programmed mitophagy at the oocyte-to-zygote transition promotes lineage endurance	68
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions	66
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool	66
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity	66
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming	65
ATM counteracts chromatin-bound cGAS during DNA replication	65
Aberrant amino acid-sensing promotes immunotherapy resistance via the inflammatory cytokine–ZBTB5–mTORC1 axis	64
Cell-intrinsic and microenvironmental determinants of metastatic colonization	64
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes	63
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development	63
Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment	63
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope	63
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity	62
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	62
The transcription factor GABPA is a master regulator of naive pluripotency	62
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis	61
Keeping up with the Rag GTPases	61
A foundation for tomorrow’s discoveries in cell biology	60
Author Correction: Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants	60
CoCo-ST detects global and local biological structures in spatial transcriptomics datasets	59
Author Correction: Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	59
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma	59
Publisher Correction: m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	59
Active size control of condensates by a kinase-based mechanism	58
A milestone in epithelial–mesenchymal transition	58
A guide to using embedded ethics in human stem-cell-based embryo model research	58
CAF heterogeneity and dynamics	58
Young secretory proteins go through a phase	58
Revealing the order of chromatin reorganization events with Dam&ChIC	57
Mitochondrial YME1L1 governs unoccupied protein translocase channels	57
Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis	57
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux	57
DNA nanodevices detect an acidic nanolayer on the lysosomal surface	57
Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1	56
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis	56
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions	56
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing	56
Autophagy-targeted NBR1–p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH	55
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung	55
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis	55
Proximal proteomics reveals a landscape of human nuclear condensates	54
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division	54
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy	54
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation	53
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes	53
The molecular basis of human transcription-coupled DNA repair	53
Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma	53
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression	52
Mapping T cell landscapes in B cell lymphomas	52
From phage genetics to chromosomes as mechanical objects	52
Conference accessibility should be a universal concern	51
Long life depends on open communication	51
A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling	51
Cell origin of BRCA2-mutant breast cancer	51
Author Correction: Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development	51
Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities	50
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels	49
Modelling co-development between the somites and neural tube in human trunk-like structures	49
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth	49
Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction	49
ERCC6L2–CtIP condensation tunes end resection	49
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	48
Shaping the composition of the mitochondrial outer membrane	48
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT	48
The proteomic landscape and temporal dynamics of human and mouse gastruloid development	48
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells	48
Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis	48
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression	47
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion	47
Fuelling basement membrane invasion	47
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis	47
Cancer-associated fibroblasts regulate DNA repair in pancreatic cancer through NDRG1-mediated R-loop processing	47
Diet and longevity	46
Arginyl-tRNA synthetase in inflammation	46

Worrying through the ECM	46
Spatial transcriptomic characterization of a Carnegie stage 7 human embryo	46
A bridge-like lipid transport protein controls plasma membrane lipid composition and fluidity	45
From fallout to renewal	45
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis	44
Author Correction: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	44
Cracking glioblastoma core regulatory codes	44
Author Correction: Stiff matrix induces exosome secretion to promote tumour growth	44
Navigating human embryogenesis through tailored model selection	44
Target cell cortical tension regulates macrophage trogocytosis	44
Metabolites in tumour interstitial fluid directly suppress T cells	44
The spectrin cytoskeleton integrates endothelial mechanoresponses	43
Ribophagy relies on Rpl12	43
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases	43
Nuclear mechanics as a determinant of nuclear pore complex plasticity	43
Harnessing introns to monitor gene expression	43
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier	42
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling	42
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	42
An expanding repertoire of E3 ligases in membrane Atg8ylation	42
Visualizing suborganellar lipid distribution using correlative light and electron microscopy	41
Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis	41
Stiff matrix induces exosome secretion to promote tumour growth	40
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation	40
In situ architecture of the human prohibitin complex	40
RNA sequestration in P-bodies sustains myeloid leukaemia	40
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition	40
Membrane bridges and nanodomain partitioning govern membrane protein targeting to lipid droplets	40
CD160 dictates anti-PD-1 immunotherapy resistance by regulating CD8+ T cell exhaustion in colorectal cancer	40
Evidence for widespread cytoplasmic structuring into mesoscale condensates	40
Order and disorder in clathrin-mediated endocytosis	40
Pausing pluripotency via RNA methylation	39
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation	39
METTL3 restrains autoimmunity in β-cells	39
Author Correction: SERRATE drives phase separation behaviours to regulate m6A modification and miRNA biogenesis	39
Intrinsically disordered CO2 sensors	39
FUS maintains TAZ fluidity and function	39
Breaking up translation condensates in cancer	38
Morula-derived trophectoderm stem cells	38
Remote control of AMPK via extracellular adenosine controls tissue growth	38
Forcing cell fate	38
Lipidomes define immune cell identity	38
Celebrating 25 years of cell biology	38
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers	38
A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures	37
Ex vivo imaging reveals the spatiotemporal control of ovulation	37
Neutrophil-derived migrasomes are an essential part of the coagulation system	37
Tracking the fates of cystine in tumours	37
Lysosome lipid signalling from the periphery to neurons regulates longevity	37
Programmable macromolecule delivery via engineered trogocytosis	37
RNA-specific local translation is patterned by condensates for multinucleate cell growth	37
Crossover patterning through condensation and coarsening of pro-crossover factors	36
Nuclear pores safeguard the integrity of the nuclear envelope	36
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection	35
Boosting cargo turnover with receptor mobility	35
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes	35
A new cell in an old tactile sensory organ	35
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos	35
Role of vinculin in metabolism	34
RNA-binding proteins pull in chromatin loops	34
Sperm miRNAs exercise benefits	34
Sperm bud mitochondria to adjust the numbers	34
Gender equity: toward redefining values	34
Sugar unmasking for trafficking	34
Harnessing lysohormesis for healthy ageing	33
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins	33
Retinoic acid induces human gastruloids with posterior embryo-like structures	33
Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma	33
Alu RNAs organize transcription at speckles	33
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing	33
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability	33
NAD+ regulates nucleotide metabolism and genomic DNA replication	33
RNA scaffolds the Golgi ribbon by forming condensates with GM130	32
In situ cryo-ET defines the ultrastructure of ER exit sites in human cells	32
Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability	32
A comprehensive tRNA pseudouridine map uncovers targets dependent on human stand-alone pseudouridine synthases	32
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites	32
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules	32
Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants	32
Diffusing caveolin-1 scaffolds regulate mechanosignalling	32
Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer’s brains	32
Lessons from infrastructure and research advocacy in India	31
Cytoplasmic control of spindle architecture	31
Now is the greatest time to be in it	31
In vivo models bring FSP1 inhibitors to life	31
Host protection by two memory-like MAIT subsets	31
Grow up, beta cells	31
Profiling cell death in COVID-19 pathology	31
How condensates tune syncytial translation	31
Combinatorial selective ER-phagy remodels the ER during neurogenesis	31
NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling	31
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation	31
Reaffirming the value of model organisms in training scientific minds	31
PTEN checkMAITs type-17 innate-like T cells	31
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila	30