Nature Cell Biology

Papers
(The TQCC of Nature Cell Biology is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)
ArticleCitations
STING and fat crosstalk687
TRIM8 in Ewing sarcoma460
Force boosts SARS-CoV-2 invasion369
Enhancing T cell therapy280
Pushing chromatin to totipotency227
Restoring placental methylome224
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage200
Criteria for the standardization of stem-cell-based embryo models191
Compression-dependent microtubule reinforcement enables cells to navigate confined environments175
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription171
The guinea pig serves as an alternative model to study human preimplantation development157
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells157
Unravelling the endoplasmic reticulum–Golgi intermediate compartment in plant cells144
tRNA flux and consistency in differentiation139
Keeping membraneless organelles apart139
An inflammatory switch for stem cell plasticity135
COPIng with senescence134
Finding a chaperone for TDP-43131
RIPK1 and RIPK3 form mosaic necrosomes126
ER-associated RNA silencing promotes ER quality control124
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication121
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function120
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis119
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources118
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ116
A guideline on the molecular ecosystem regulating ferroptosis115
Telomere dysfunction in ageing and age-related diseases114
A serendipitous discovery of a family of membrane remodelling proteins112
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture112
Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1111
Regenerating the academic pipeline107
Publisher Correction: p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth104
HSF1 renders NK cells too stressed to respond104
PRC2 shields the potency of human stem cells104
How a ribosomal protein avoids mixed signals104
TCF3, TCF12 and distinct enhancers regulate oocyte transcription102
Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer101
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription100
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis100
Nuclear class 3 PI3K coactivates circadian clock98
Membranes regulate biomolecular condensates97
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise96
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer96
Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth94
Real-time and programmable transcriptome sequencing with PROFIT-seq91
Implementing sustainable science in the lab90
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates89
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification88
A lysosomal surveillance response to stress extends healthspan87
Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements86
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation86
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis83
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis83
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration83
Spermidine is essential for fasting-mediated autophagy and longevity83
A cell biological perspective on Singapore’s scientific growth82
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells82
Xist seeds X inactivation81
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor81
Deep-learning for microscopy81
Time for lipid cell biology79
Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells79
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities77
Telomeres are a life-extending gift74
It started with a western74
Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs72
Waste management and cell death in T cells72
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth71
Tissue memory relies on stem cell priming in distal undamaged areas71
Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning70
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome70
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system70
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells69
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification68
Sequential enhancer state remodelling defines human germline competence and specification67
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling66
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition65
The role of PINK1–Parkin in mitochondrial quality control63
Surveying the dividing genome63
The transcription factor GABPA is a master regulator of naive pluripotency62
Single-cell spatial transcriptomics62
Publisher Correction: Epithelial cell plasticity drives endoderm formation during gastrulation61
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity60
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity60
ASTE1 cutting to block DNA end resection60
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions59
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair59
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope59
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes58
Cell-intrinsic and microenvironmental determinants of metastatic colonization57
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development57
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool57
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair57
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness56
Phase separation of EB1 guides microtubule plus-end dynamics56
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming55
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing55
Keeping up with the Rag GTPases54
Author Correction: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation54
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance54
Golden opportunity for piRNA in female fertility54
Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis53
Author Correction: Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification53
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing53
Author Correction: Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants53
A milestone in epithelial–mesenchymal transition52
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma52
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy52
Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells52
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis52
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division51
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung51
Publisher Correction: m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency51
Mitochondrial YME1L1 governs unoccupied protein translocase channels50
Autophagy-targeted NBR1–p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH50
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes50
Multiplexed genome regulation in vivo with hyper-efficient Cas12a50
Lysate-based pipeline to characterize microtubule-associated proteins uncovers unique microtubule behaviours50
The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels50
CAF heterogeneity and dynamics50
A single-cell transcriptomic landscape of the lungs of patients with COVID-1950
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis50
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation49
From phage genetics to chromosomes as mechanical objects49
Species-specific cortex features49
COVID-19 lung atlas49
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions49
Cell type ontologies of the Human Cell Atlas49
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression49
Mapping T cell landscapes in B cell lymphomas48
A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling48
Shaping the composition of the mitochondrial outer membrane47
Dissecting melanocytes to predict melanoma47
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels47
Publisher Correction: POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis47
Cell origin of BRCA2-mutant breast cancer47
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression47
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT46
Rear traction forces drive adherent tissue migration in vivo46
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion46
Long life depends on open communication46
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis46
Spatial transcriptomic characterization of a Carnegie stage 7 human embryo45
Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities45
Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma44
Conference accessibility should be a universal concern44
VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells44
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition44
Diet and longevity43
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination43
Harnessing introns to monitor gene expression43
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth43
Worrying through the ECM42
Author Correction: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids42
Mapping paths through the nuclear pore complex42
Ribophagy relies on Rpl1242
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis41
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis41
Navigating human embryogenesis through tailored model selection41
Arginyl-tRNA synthetase in inflammation41
RNA sequestration in P-bodies sustains myeloid leukaemia41
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases41
In situ architecture of the human prohibitin complex40
Author Correction: Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly40
Author Correction: Stiff matrix induces exosome secretion to promote tumour growth40
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation39
Metabolites in tumour interstitial fluid directly suppress T cells39
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling39
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency38
NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency38
Order and disorder in clathrin-mediated endocytosis37
FUS maintains TAZ fluidity and function37
Evidence for widespread cytoplasmic structuring into mesoscale condensates37
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition37
Modelling SARS-CoV-2 CNS infection37
The spectrin cytoskeleton integrates endothelial mechanoresponses37
An expanding repertoire of E3 ligases in membrane Atg8ylation37
METTL3 restrains autoimmunity in β-cells37
Stiff matrix induces exosome secretion to promote tumour growth37
A chosen STING with a PERKy trail36
Intrinsically disordered CO2 sensors36
Pausing pluripotency via RNA methylation36
Mitochondrial shape alteration by metabolites36
Breaking up translation condensates in cancer35
Ex vivo imaging reveals the spatiotemporal control of ovulation35
Crossover patterning through condensation and coarsening of pro-crossover factors35
Celebrating 25 years of cell biology35
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity35
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers35
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection35
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation35
Lysosome lipid signalling from the periphery to neurons regulates longevity34
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression34
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos34
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes34
CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development34
Lipidomes define immune cell identity34
Neutrophil-derived migrasomes are an essential part of the coagulation system34
Nuclear pores safeguard the integrity of the nuclear envelope34
Sperm bud mitochondria to adjust the numbers33
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules33
Human neural tube morphogenesis in a dish33
Gender equity: toward redefining values33
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase33
Boosting cargo turnover with receptor mobility33
A new cell in an old tactile sensory organ33
Sugar unmasking for trafficking33
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability32
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing32
NAD+ regulates nucleotide metabolism and genomic DNA replication32
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation32
Softening redox homeostasis in cancer cells32
FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance31
Combinatorial selective ER-phagy remodels the ER during neurogenesis31
Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants31
Harnessing lysohormesis for healthy ageing31
Retinoic acid induces human gastruloids with posterior embryo-like structures31
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites31
RNA scaffolds the Golgi ribbon by forming condensates with GM13031
How cell biology can save the planet30
Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan30
PTEN checkMAITs type-17 innate-like T cells29
Author Correction: Defining E3 ligase–substrate relationships through multiplex CRISPR screening29
Lessons from infrastructure and research advocacy in India29
Stress response regulates cancer fibroblasts29
Now is the greatest time to be in it29
Disulfidptosis meets antitumour immunity29
A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts29
Biases in machine-learning models of human single-cell data29
Grow up, beta cells28
Cytoplasmic control of spindle architecture28
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis28
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics28
Profiling cell death in COVID-19 pathology27
LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR827
CLICing on endocytic cargoes for cancer invasion27
Temporal and spatial topography of cell proliferation in cancer27
Stem cell progeny liaisons in regeneration27
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila27
Architecture and dynamics of a desmosome–endoplasmic reticulum complex26
Deadly actin collapse by disulfidptosis26
Eosinophil extracellular traps drive asthma progression through neuro-immune signals26
NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling26
Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition26
Cohesin regulates homology search during recombinational DNA repair26
RETRACTED ARTICLE: CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling26
Publisher Correction: o8G modifications rewire tumoral microRNAs26
Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome26
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes26
Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns26
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