Nature Cell Biology

Article	Citations
STING and fat crosstalk	687
TRIM8 in Ewing sarcoma	460
Force boosts SARS-CoV-2 invasion	369
Enhancing T cell therapy	280
Pushing chromatin to totipotency	227
Restoring placental methylome	224
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage	200
Criteria for the standardization of stem-cell-based embryo models	191
Compression-dependent microtubule reinforcement enables cells to navigate confined environments	175
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription	171
The guinea pig serves as an alternative model to study human preimplantation development	157
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells	157
Unravelling the endoplasmic reticulum–Golgi intermediate compartment in plant cells	144
tRNA flux and consistency in differentiation	139
Keeping membraneless organelles apart	139
An inflammatory switch for stem cell plasticity	135
COPIng with senescence	134
Finding a chaperone for TDP-43	131
RIPK1 and RIPK3 form mosaic necrosomes	126
ER-associated RNA silencing promotes ER quality control	124
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication	121
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function	120
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis	119
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources	118
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ	116

A guideline on the molecular ecosystem regulating ferroptosis	115
Telomere dysfunction in ageing and age-related diseases	114
A serendipitous discovery of a family of membrane remodelling proteins	112
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture	112
Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1	111
Regenerating the academic pipeline	107
Publisher Correction: p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth	104
HSF1 renders NK cells too stressed to respond	104
PRC2 shields the potency of human stem cells	104
How a ribosomal protein avoids mixed signals	104
TCF3, TCF12 and distinct enhancers regulate oocyte transcription	102
Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer	101
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription	100
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis	100
Nuclear class 3 PI3K coactivates circadian clock	98
Membranes regulate biomolecular condensates	97
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise	96
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer	96
Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth	94
Real-time and programmable transcriptome sequencing with PROFIT-seq	91
Implementing sustainable science in the lab	90
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates	89
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	88
A lysosomal surveillance response to stress extends healthspan	87
Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements	86
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation	86
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis	83
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	83
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration	83
Spermidine is essential for fasting-mediated autophagy and longevity	83
A cell biological perspective on Singapore’s scientific growth	82
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells	82
Xist seeds X inactivation	81
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor	81
Deep-learning for microscopy	81
Time for lipid cell biology	79
Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells	79
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities	77
Telomeres are a life-extending gift	74
It started with a western	74
Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs	72
Waste management and cell death in T cells	72
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth	71
Tissue memory relies on stem cell priming in distal undamaged areas	71
Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning	70
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome	70
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system	70
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells	69
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification	68
Sequential enhancer state remodelling defines human germline competence and specification	67

A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling	66
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition	65
The role of PINK1–Parkin in mitochondrial quality control	63
Surveying the dividing genome	63
The transcription factor GABPA is a master regulator of naive pluripotency	62
Single-cell spatial transcriptomics	62
Publisher Correction: Epithelial cell plasticity drives endoderm formation during gastrulation	61
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity	60
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity	60
ASTE1 cutting to block DNA end resection	60
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions	59
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair	59
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope	59
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes	58
Cell-intrinsic and microenvironmental determinants of metastatic colonization	57
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development	57
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool	57
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair	57
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness	56
Phase separation of EB1 guides microtubule plus-end dynamics	56
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming	55
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	55
Keeping up with the Rag GTPases	54
Author Correction: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation	54
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance	54
Golden opportunity for piRNA in female fertility	54
Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis	53
Author Correction: Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	53
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing	53
Author Correction: Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants	53
A milestone in epithelial–mesenchymal transition	52
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma	52
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy	52
Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells	52
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis	52
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division	51
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung	51
Publisher Correction: m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	51
Mitochondrial YME1L1 governs unoccupied protein translocase channels	50
Autophagy-targeted NBR1–p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH	50
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes	50
Multiplexed genome regulation in vivo with hyper-efficient Cas12a	50
Lysate-based pipeline to characterize microtubule-associated proteins uncovers unique microtubule behaviours	50
The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels	50
CAF heterogeneity and dynamics	50
A single-cell transcriptomic landscape of the lungs of patients with COVID-19	50
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis	50
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation	49
From phage genetics to chromosomes as mechanical objects	49
Species-specific cortex features	49
COVID-19 lung atlas	49
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions	49
Cell type ontologies of the Human Cell Atlas	49
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression	49
Mapping T cell landscapes in B cell lymphomas	48
A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling	48
Shaping the composition of the mitochondrial outer membrane	47
Dissecting melanocytes to predict melanoma	47
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels	47
Publisher Correction: POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis	47
Cell origin of BRCA2-mutant breast cancer	47
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression	47
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT	46
Rear traction forces drive adherent tissue migration in vivo	46
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion	46
Long life depends on open communication	46
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis	46
Spatial transcriptomic characterization of a Carnegie stage 7 human embryo	45
Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities	45
Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma	44
Conference accessibility should be a universal concern	44
VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells	44
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	44
Diet and longevity	43
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination	43
Harnessing introns to monitor gene expression	43
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth	43
Worrying through the ECM	42
Author Correction: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	42
Mapping paths through the nuclear pore complex	42

Ribophagy relies on Rpl12	42
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis	41
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis	41
Navigating human embryogenesis through tailored model selection	41
Arginyl-tRNA synthetase in inflammation	41
RNA sequestration in P-bodies sustains myeloid leukaemia	41
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases	41
In situ architecture of the human prohibitin complex	40
Author Correction: Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly	40
Author Correction: Stiff matrix induces exosome secretion to promote tumour growth	40
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation	39
Metabolites in tumour interstitial fluid directly suppress T cells	39
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling	39
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	38
NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency	38
Order and disorder in clathrin-mediated endocytosis	37
FUS maintains TAZ fluidity and function	37
Evidence for widespread cytoplasmic structuring into mesoscale condensates	37
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition	37
Modelling SARS-CoV-2 CNS infection	37
The spectrin cytoskeleton integrates endothelial mechanoresponses	37
An expanding repertoire of E3 ligases in membrane Atg8ylation	37
METTL3 restrains autoimmunity in β-cells	37
Stiff matrix induces exosome secretion to promote tumour growth	37
A chosen STING with a PERKy trail	36
Intrinsically disordered CO2 sensors	36
Pausing pluripotency via RNA methylation	36
Mitochondrial shape alteration by metabolites	36
Breaking up translation condensates in cancer	35
Ex vivo imaging reveals the spatiotemporal control of ovulation	35
Crossover patterning through condensation and coarsening of pro-crossover factors	35
Celebrating 25 years of cell biology	35
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity	35
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers	35
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection	35
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation	35
Lysosome lipid signalling from the periphery to neurons regulates longevity	34
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression	34
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos	34
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes	34
CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development	34
Lipidomes define immune cell identity	34
Neutrophil-derived migrasomes are an essential part of the coagulation system	34
Nuclear pores safeguard the integrity of the nuclear envelope	34
Sperm bud mitochondria to adjust the numbers	33
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules	33
Human neural tube morphogenesis in a dish	33
Gender equity: toward redefining values	33
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase	33
Boosting cargo turnover with receptor mobility	33
A new cell in an old tactile sensory organ	33
Sugar unmasking for trafficking	33
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability	32
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing	32
NAD+ regulates nucleotide metabolism and genomic DNA replication	32
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation	32
Softening redox homeostasis in cancer cells	32
FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance	31
Combinatorial selective ER-phagy remodels the ER during neurogenesis	31
Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants	31
Harnessing lysohormesis for healthy ageing	31
Retinoic acid induces human gastruloids with posterior embryo-like structures	31
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites	31
RNA scaffolds the Golgi ribbon by forming condensates with GM130	31
How cell biology can save the planet	30
Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan	30
PTEN checkMAITs type-17 innate-like T cells	29
Author Correction: Defining E3 ligase–substrate relationships through multiplex CRISPR screening	29
Lessons from infrastructure and research advocacy in India	29
Stress response regulates cancer fibroblasts	29
Now is the greatest time to be in it	29
Disulfidptosis meets antitumour immunity	29
A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts	29
Biases in machine-learning models of human single-cell data	29
Grow up, beta cells	28
Cytoplasmic control of spindle architecture	28
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis	28
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics	28
Profiling cell death in COVID-19 pathology	27
LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8	27
CLICing on endocytic cargoes for cancer invasion	27
Temporal and spatial topography of cell proliferation in cancer	27
Stem cell progeny liaisons in regeneration	27
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila	27
Architecture and dynamics of a desmosome–endoplasmic reticulum complex	26
Deadly actin collapse by disulfidptosis	26
Eosinophil extracellular traps drive asthma progression through neuro-immune signals	26
NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling	26
Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition	26
Cohesin regulates homology search during recombinational DNA repair	26
RETRACTED ARTICLE: CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling	26
Publisher Correction: o8G modifications rewire tumoral microRNAs	26
Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome	26
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes	26
Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns	26