Nature Cell Biology

Papers
(The TQCC of Nature Cell Biology is 25. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
STING and fat crosstalk635
TRIM8 in Ewing sarcoma420
Force boosts SARS-CoV-2 invasion350
Enhancing T cell therapy325
Pushing chromatin to totipotency267
Restoring placental methylome213
Unravelling the endoplasmic reticulum–Golgi intermediate compartment in plant cells211
Keeping membraneless organelles apart181
tRNA flux and consistency in differentiation171
Immune memory in individuals with COVID-19164
An inflammatory switch for stem cell plasticity159
COPIng with senescence157
The guinea pig serves as an alternative model to study human preimplantation development153
Finding a chaperone for TDP-43148
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription136
Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity133
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication129
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis128
RIPK1 and RIPK3 form mosaic necrosomes125
ER-associated RNA silencing promotes ER quality control125
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources123
Compression-dependent microtubule reinforcement enables cells to navigate confined environments120
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture118
A guideline on the molecular ecosystem regulating ferroptosis117
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage116
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ113
Telomere dysfunction in ageing and age-related diseases112
Criteria for the standardization of stem-cell-based embryo models110
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function109
Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1106
A serendipitous discovery of a family of membrane remodelling proteins106
Implementing sustainable science in the lab106
Regenerating the academic pipeline104
Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer101
How a ribosomal protein avoids mixed signals101
Nuclear class 3 PI3K coactivates circadian clock100
Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements98
Real-time and programmable transcriptome sequencing with PROFIT-seq95
Publisher Correction: p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth95
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification95
Spermidine is essential for fasting-mediated autophagy and longevity92
The mechanics of crypt morphogenesis92
PRC2 shields the potency of human stem cells91
HSF1 renders NK cells too stressed to respond90
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise90
Membranes regulate biomolecular condensates87
Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth87
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation87
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration86
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis85
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates84
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis81
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis81
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells81
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer80
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription80
TCF3, TCF12 and distinct enhancers regulate oocyte transcription78
A cell biological perspective on Singapore’s scientific growth77
Sequential enhancer state remodelling defines human germline competence and specification77
Time for lipid cell biology77
Deep-learning for microscopy77
Xist seeds X inactivation77
Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs76
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system75
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling75
Tissue memory relies on stem cell priming in distal undamaged areas75
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome73
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells72
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification71
Mapping the foetal striatum71
Telomeres are a life-extending gift71
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor71
It started with a western70
Waste management and cell death in T cells67
Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning67
Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells67
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth66
The role of PINK1–Parkin in mitochondrial quality control65
Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker65
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities64
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition64
Surveying the dividing genome63
The transcription factor GABPA is a master regulator of naive pluripotency63
Single-cell spatial transcriptomics63
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness62
Publisher Correction: Epithelial cell plasticity drives endoderm formation during gastrulation62
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions60
ASTE1 cutting to block DNA end resection60
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity59
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope59
Phase separation of EB1 guides microtubule plus-end dynamics58
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair58
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming57
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes57
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair56
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool56
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance56
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity56
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development56
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing56
Cell-intrinsic and microenvironmental determinants of metastatic colonization56
CAF heterogeneity and dynamics55
Keeping up with the Rag GTPases54
Golden opportunity for piRNA in female fertility52
Author Correction: Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants52
Author Correction: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation52
Author Correction: Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification52
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing52
Publisher Correction: m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency51
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma51
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis51
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions50
Lysate-based pipeline to characterize microtubule-associated proteins uncovers unique microtubule behaviours50
Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells50
Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis50
Non-invasive and high-throughput interrogation of exon-specific isoform expression50
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division50
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis50
Multiplexed genome regulation in vivo with hyper-efficient Cas12a49
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy49
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation48
The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels48
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes48
Cell type ontologies of the Human Cell Atlas48
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung48
Conference accessibility should be a universal concern47
A milestone in epithelial–mesenchymal transition47
Species-specific cortex features47
Mitochondrial YME1L1 governs unoccupied protein translocase channels47
Rear traction forces drive adherent tissue migration in vivo47
A single-cell transcriptomic landscape of the lungs of patients with COVID-1947
From phage genetics to chromosomes as mechanical objects46
Publisher Correction: POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis46
COVID-19 lung atlas46
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression46
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression46
A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling46
Mapping T cell landscapes in B cell lymphomas46
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth45
Dissecting melanocytes to predict melanoma45
Spatial transcriptomic characterization of a Carnegie stage 7 human embryo45
Long life depends on open communication44
Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma44
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion44
Cell origin of BRCA2-mutant breast cancer44
Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities43
VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells43
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels43
The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming43
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination42
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition42
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT41
Mapping paths through the nuclear pore complex41
Harnessing introns to monitor gene expression41
Diet and longevity41
Ribophagy relies on Rpl1241
Worrying through the ECM40
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling39
Navigating human embryogenesis through tailored model selection39
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases39
Author Correction: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids39
An expanding repertoire of E3 ligases in membrane Atg8ylation39
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition38
Arginyl-tRNA synthetase in inflammation38
RNA sequestration in P-bodies sustains myeloid leukaemia38
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation38
Author Correction: Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly38
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis37
NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency37
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis37
In situ architecture of the human prohibitin complex37
Metabolites in tumour interstitial fluid directly suppress T cells37
Evidence for widespread cytoplasmic structuring into mesoscale condensates37
Author Correction: Stiff matrix induces exosome secretion to promote tumour growth36
Lipidomes define immune cell identity36
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency36
FUS maintains TAZ fluidity and function36
Stiff matrix induces exosome secretion to promote tumour growth36
Modelling SARS-CoV-2 CNS infection36
The spectrin cytoskeleton integrates endothelial mechanoresponses36
METTL3 restrains autoimmunity in β-cells36
Order and disorder in clathrin-mediated endocytosis36
Pausing pluripotency via RNA methylation35
Mitochondrial shape alteration by metabolites35
Nuclear pores safeguard the integrity of the nuclear envelope35
A chosen STING with a PERKy trail35
Breaking up translation condensates in cancer35
Intrinsically disordered CO2 sensors35
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes35
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability34
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection34
CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development34
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation34
Ex vivo imaging reveals the spatiotemporal control of ovulation33
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity33
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression33
Celebrating 25 years of cell biology33
Neutrophil-derived migrasomes are an essential part of the coagulation system32
Human neural tube morphogenesis in a dish32
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers32
Lysosome lipid signalling from the periphery to neurons regulates longevity32
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos32
Softening redox homeostasis in cancer cells31
Sperm bud mitochondria to adjust the numbers31
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase31
A new cell in an old tactile sensory organ31
Boosting cargo turnover with receptor mobility31
Gender equity: toward redefining values31
FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance30
Harnessing lysohormesis for healthy ageing30
Sugar unmasking for trafficking30
Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants30
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing30
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability30
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules30
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites29
Combinatorial selective ER-phagy remodels the ER during neurogenesis29
NAD+ regulates nucleotide metabolism and genomic DNA replication29
RNA scaffolds the Golgi ribbon by forming condensates with GM13029
Generic nature of the condensed states of proteins29
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation29
Retinoic acid induces human gastruloids with posterior embryo-like structures29
How cell biology can save the planet28
Biases in machine-learning models of human single-cell data28
Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan28
Lessons from infrastructure and research advocacy in India28
PTEN checkMAITs type-17 innate-like T cells27
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics27
Eosinophil extracellular traps drive asthma progression through neuro-immune signals27
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation27
NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling27
Cohesin regulates homology search during recombinational DNA repair27
Now is the greatest time to be in it27
A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts27
ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels26
CLICing on endocytic cargoes for cancer invasion26
Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis26
Host protection by two memory-like MAIT subsets26
RETRACTED ARTICLE: CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling26
Stem cell progeny liaisons in regeneration26
Publisher Correction: o8G modifications rewire tumoral microRNAs26
Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome26
Profiling cell death in COVID-19 pathology26
Author Correction: Defining E3 ligase–substrate relationships through multiplex CRISPR screening26
Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns26
Architecture and dynamics of a desmosome–endoplasmic reticulum complex25
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila25
Deadly actin collapse by disulfidptosis25
Temporal and spatial topography of cell proliferation in cancer25
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis25
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