Nature Cell Biology

Article	Citations
Pushing chromatin to totipotency	832
STING and fat crosstalk	561
Enhancing T cell therapy	436
Unravelling the endoplasmic reticulum–Golgi intermediate compartment in plant cells	321
Keeping membraneless organelles apart	253
tRNA flux and consistency in differentiation	250
COPIng with senescence	228
Restoring placental methylome	220
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription	207
Designing protein-based artificial kinetochores as decoys to prevent meiotic errors in oocytes	205
Finding a chaperone for TDP-43	187
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells	179
ER-associated RNA silencing promotes ER quality control	177
Criteria for the standardization of stem-cell-based embryo models	170
The guinea pig serves as an alternative model to study human preimplantation development	170
Compression-dependent microtubule reinforcement enables cells to navigate confined environments	167
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication	162
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage	157
RIPK1 and RIPK3 form mosaic necrosomes	156
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function	155
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis	155
Atlas of amnion development during the first trimester of human pregnancy	151
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources	149
Telomere dysfunction in ageing and age-related diseases	146
A guideline on the molecular ecosystem regulating ferroptosis	146

Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ	144
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture	144
How a ribosomal protein avoids mixed signals	142
Regenerating the academic pipeline	140
Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1	134
A serendipitous discovery of a family of membrane remodelling proteins	132
Implementing sustainable science in the lab	131
Nuclear class 3 PI3K coactivates circadian clock	131
PRC2 shields the potency of human stem cells	127
HSF1 renders NK cells too stressed to respond	123
Real-time and programmable transcriptome sequencing with PROFIT-seq	120
TCF3, TCF12 and distinct enhancers regulate oocyte transcription	119
Membranes regulate biomolecular condensates	119
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer	115
A lysosomal surveillance response to stress extends healthspan	115
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death	112
Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer	111
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis	111
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate	110
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation	109
Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth	107
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates	106
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise	103
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells	103
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration	99
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	97
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	95
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription	95
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis	95
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis	94
A cell biological perspective on Singapore’s scientific growth	88
Spermidine is essential for fasting-mediated autophagy and longevity	88
Xist seeds X inactivation	88
Telomeres are a life-extending gift	86
Waste management and cell death in T cells	85
Time for lipid cell biology	85
It started with a western	84
Deep-learning for microscopy	84
A model for propagation of RNA structural memory through biomolecular condensates	84
Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs	83
Tissue memory relies on stem cell priming in distal undamaged areas	82
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities	82
Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning	80
Sequential enhancer state remodelling defines human germline competence and specification	80
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification	80
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system	79
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome	78
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling	78
Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells	77
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth	73

N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition	72
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor	71
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis	70
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells	70
The role of PINK1–Parkin in mitochondrial quality control	70
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity	70
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes	68
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope	67
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity	66
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions	66
The transcription factor GABPA is a master regulator of naive pluripotency	66
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness	66
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair	65
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool	65
Cell-intrinsic and microenvironmental determinants of metastatic colonization	65
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming	65
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	64
Phase separation of EB1 guides microtubule plus-end dynamics	64
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance	63
Author Correction: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation	62
Keeping up with the Rag GTPases	62
Author Correction: Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants	62
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development	62
Multiplexed genome regulation in vivo with hyper-efficient Cas12a	61
Autophagy-targeted NBR1–p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH	61
CoCo-ST detects global and local biological structures in spatial transcriptomics datasets	61
CAF heterogeneity and dynamics	60
Lysate-based pipeline to characterize microtubule-associated proteins uncovers unique microtubule behaviours	60
Publisher Correction: m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	60
Author Correction: Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	59
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma	59
Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis	58
The molecular basis of human transcription-coupled DNA repair	58
Revealing the order of chromatin reorganization events with Dam&ChIC	58
Young secretory proteins go through a phase	58
Mitochondrial YME1L1 governs unoccupied protein translocase channels	57
A milestone in epithelial–mesenchymal transition	57
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung	57
A single-cell transcriptomic landscape of the lungs of patients with COVID-19	56
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions	56
Proximal proteomics reveals a landscape of human nuclear condensates	55
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes	55
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy	54
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis	54
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis	54
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing	54
Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells	53
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division	53
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation	53
Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma	52
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression	52
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux	52
Long life depends on open communication	51
Mapping T cell landscapes in B cell lymphomas	51
Cell origin of BRCA2-mutant breast cancer	51
From phage genetics to chromosomes as mechanical objects	51
ERCC6L2–CtIP condensation tunes end resection	51
Conference accessibility should be a universal concern	51
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT	50
Author Correction: Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development	50
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells	50
VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells	49
Rear traction forces drive adherent tissue migration in vivo	49
Shaping the composition of the mitochondrial outer membrane	49
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth	49
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion	49
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression	48
Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities	48
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	48
A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling	48
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels	48
Diet and longevity	47
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis	47
Spatial transcriptomic characterization of a Carnegie stage 7 human embryo	47
Harnessing introns to monitor gene expression	47
Author Correction: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	46
Author Correction: Stiff matrix induces exosome secretion to promote tumour growth	46
Ribophagy relies on Rpl12	46
Worrying through the ECM	46
Mapping paths through the nuclear pore complex	46

Arginyl-tRNA synthetase in inflammation	45
Metabolites in tumour interstitial fluid directly suppress T cells	45
CD160 dictates anti-PD-1 immunotherapy resistance by regulating CD8+ T cell exhaustion in colorectal cancer	45
Navigating human embryogenesis through tailored model selection	45
A bridge-like lipid transport protein controls plasma membrane lipid composition and fluidity	44
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation	44
An expanding repertoire of E3 ligases in membrane Atg8ylation	44
Cracking glioblastoma core regulatory codes	44
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling	43
In situ architecture of the human prohibitin complex	43
The spectrin cytoskeleton integrates endothelial mechanoresponses	43
Nuclear mechanics as a determinant of nuclear pore complex plasticity	42
From fallout to renewal	42
RNA sequestration in P-bodies sustains myeloid leukaemia	42
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis	42
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition	42
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases	42
Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis	42
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis	42
Stiff matrix induces exosome secretion to promote tumour growth	41
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	41
METTL3 restrains autoimmunity in β-cells	41
Evidence for widespread cytoplasmic structuring into mesoscale condensates	41
Order and disorder in clathrin-mediated endocytosis	41
NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency	41
Pausing pluripotency via RNA methylation	41
Intrinsically disordered CO2 sensors	41
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection	40
Mitochondrial shape alteration by metabolites	40
A chosen STING with a PERKy trail	40
FUS maintains TAZ fluidity and function	40
Forcing cell fate	39
Remote control of AMPK via extracellular adenosine controls tissue growth	39
Morula-derived trophectoderm stem cells	39
CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development	38
Crossover patterning through condensation and coarsening of pro-crossover factors	38
Celebrating 25 years of cell biology	38
Nuclear pores safeguard the integrity of the nuclear envelope	38
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers	38
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation	37
Breaking up translation condensates in cancer	37
Lipidomes define immune cell identity	37
Lysosome lipid signalling from the periphery to neurons regulates longevity	37
Ex vivo imaging reveals the spatiotemporal control of ovulation	37
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes	36
Human neural tube morphogenesis in a dish	36
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression	36
Boosting cargo turnover with receptor mobility	36
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos	36
Neutrophil-derived migrasomes are an essential part of the coagulation system	36
A new cell in an old tactile sensory organ	36
Softening redox homeostasis in cancer cells	35
Sperm bud mitochondria to adjust the numbers	35
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability	35
Sugar unmasking for trafficking	35
Harnessing lysohormesis for healthy ageing	35
RNA-binding proteins pull in chromatin loops	35
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules	34
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation	34
A comprehensive tRNA pseudouridine map uncovers targets dependent on human stand-alone pseudouridine synthases	34
Gender equity: toward redefining values	34
NAD+ regulates nucleotide metabolism and genomic DNA replication	34
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins	34
RNA scaffolds the Golgi ribbon by forming condensates with GM130	34
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase	33
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites	33
Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma	33
Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants	33
Retinoic acid induces human gastruloids with posterior embryo-like structures	33
Combinatorial selective ER-phagy remodels the ER during neurogenesis	33
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing	33
Cytoplasmic control of spindle architecture	32
Lessons from infrastructure and research advocacy in India	32
Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan	32
How cell biology can save the planet	32
Host protection by two memory-like MAIT subsets	32
PTEN checkMAITs type-17 innate-like T cells	31
Stress response regulates cancer fibroblasts	31
Author Correction: Defining E3 ligase–substrate relationships through multiplex CRISPR screening	31
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila	31
Grow up, beta cells	31
Now is the greatest time to be in it	31
Profiling cell death in COVID-19 pathology	31
Temporal and spatial topography of cell proliferation in cancer	30
Publisher Correction: o8G modifications rewire tumoral microRNAs	30
ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels	30
Haematopoietic ageing in health and lifespan	30
Cholesterol sensing by the SCAP–FAM134B complex regulates ER-phagy and STING innate immunity	30
Reaffirming the value of model organisms in training scientific minds	30
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation	30
Biases in machine-learning models of human single-cell data	30
Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition	30
Deciphering glioma susceptibility	30
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation	29
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics	29