Nature Cell Biology

Article	Citations
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis	491
Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis	295
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis	259
Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture	226
SIRT1 is downregulated by autophagy in senescence and ageing	225
Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker	212
Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion	204
CRISPR technologies for precise epigenome editing	204
Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression	203
Telomere dysfunction in ageing and age-related diseases	197
PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis	185
Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling	182
Nucleated transcriptional condensates amplify gene expression	180
Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy	178
Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	170
Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity	154
Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma	152
Targeted reprogramming of H3K27me3 resets epigenetic memory in plant paternal chromatin	146
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis	144
Cellular and molecular architecture of the intestinal stem cell niche	123
ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration	122
Evaluating totipotency using criteria of increasing stringency	118
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury	116
AP-1 imprints a reversible transcriptional programme of senescent cells	111
FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome	111

Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity	109
PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications	108
Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration	108
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells	108
Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling	107
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control	105
Liquid-like protein interactions catalyse assembly of endocytic vesicles	103
Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis	99
Cell fate coordinates mechano-osmotic forces in intestinal crypt formation	97
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age	94
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation	94
Generic nature of the condensed states of proteins	93
In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states	93
R-loops as Janus-faced modulators of DNA repair	93
The STING phase-separator suppresses innate immune signalling	92
Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels	92
LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy	91
Autophagosome biogenesis comes out of the black box	90
UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination	90
A single-cell transcriptomic landscape of the lungs of patients with COVID-19	90
LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes	89
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis	86
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA	86
Phase separation of SERRATE drives dicing body assembly and promotes miRNA processing in Arabidopsis	86
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression	85
Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress	85
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells	84
Lis1 activates dynein motility by modulating its pairing with dynactin	84
Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses	83
Extracellular serine controls epidermal stem cell fate and tumour initiation	83
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis	82
Depletion of aneuploid cells in human embryos and gastruloids	82
Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance	79
Overcoming Wnt–β-catenin dependent anticancer therapy resistance in leukaemia stem cells	78
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation	73
Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling	72
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance	72
The chromatin remodeler DDM1 prevents transposon mobility through deposition of histone variant H2A.W	71
Cell type ontologies of the Human Cell Atlas	70
An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer	70
p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth	70
Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain	70
m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype	70
Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3	70
TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis	70
Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein	70
STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury	69
Metabolic communication in the tumour–immune microenvironment	68
Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish	68
Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity	68

Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses	67
Membrane surfaces regulate assembly of ribonucleoprotein condensates	67
Loss of ELF5–FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling	67
Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation	66
Anatomical structures, cell types and biomarkers of the Human Reference Atlas	65
Exploring the expanding universe of small RNAs	65
Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity	65
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung	64
Proteotoxic stress is a driver of the loser status and cell competition	64
The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC	64
METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis	63
Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis	63
Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19	62
Mechanical force application to the nucleus regulates nucleocytoplasmic transport	61
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin	60
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia	60
Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock	59
Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development	57
Human melanocyte development and melanoma dedifferentiation at single-cell resolution	57
POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis	56
Control of endothelial quiescence by FOXO-regulated metabolites	54
A PRC2-independent function for EZH2 in regulating rRNA 2′-O methylation and IRES-dependent translation	54
Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis	54
Heat stress activates YAP/TAZ to induce the heat shock transcriptome	54
Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens	54
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis	53
The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels	52
NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices	52
Functional mechanisms and abnormalities of the nuclear lamina	52
Spatial organization of transcribed eukaryotic genes	52
A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression	51
Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility	51
Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation	51
SMN-primed ribosomes modulate the translation of transcripts related to spinal muscular atrophy	51
Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations	50
The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin	50
Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition	49
Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning	49
An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory	48
SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization	47
Metabolic determination of cell fate through selective inheritance of mitochondria	47
ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism	46
Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis	46
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	46
Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome	46
The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming	46
Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks	46
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2	45
Nucleotide imbalance decouples cell growth from cell proliferation	45
STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy	45
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing	44
Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates	44
The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells	43
Phosphatidylinositol 3-kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4	42
Cell cycle-specific phase separation regulated by protein charge blockiness	42
Eosinophil extracellular traps drive asthma progression through neuro-immune signals	42
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling	42
Global profiling of RNA-binding protein target sites by LACE-seq	42
Cohesin regulates homology search during recombinational DNA repair	42
ATG9A protects the plasma membrane from programmed and incidental permeabilization	42
Recycling of autophagosomal components from autolysosomes by the recycler complex	42
Epithelial cell plasticity drives endoderm formation during gastrulation	42
Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration	41
Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues	41
Multiplexed genome regulation in vivo with hyper-efficient Cas12a	40
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability	40
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth	40
CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling	40
E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis	40
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes	40
Stiff matrix induces exosome secretion to promote tumour growth	39
Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea	39
Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain	38
Untangling the web of intratumour heterogeneity	38
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics	38
Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration	38
LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy	38
Deadly actin collapse by disulfidptosis	37
Dissecting OCT4 defines the role of nucleosome binding in pluripotency	36
Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements	36

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases	36
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity	36
ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation	36
Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth	35
A reversible shearing DNA probe for visualizing mechanically strong receptors in living cells	35
Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechanosensitive structures	35
Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death	35
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation	35
Illuminating RNA biology through imaging	35
Single-cell atlas of human liver development reveals pathways directing hepatic cell fates	34
Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage	33
BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling	33
Reciprocal regulation of chaperone-mediated autophagy and the circadian clock	33
Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis	33
Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma	33
LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria	33
Temporal and spatial topography of cell proliferation in cancer	33
Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly	33
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	32
Substoichiometric action of long noncoding RNAs	32
Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions	32
Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis	32
A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers	32
A transitional stem cell state in the lung	32
The piRNA pathway is essential for generating functional oocytes in golden hamsters	32
CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells	31
Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction	31
Mammalian genome innovation through transposon domestication	31
Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs	30
Identification of two pathways mediating protein targeting from ER to lipid droplets	30
A biomechanical switch regulates the transition towards homeostasis in oesophageal epithelium	30
Loss of lenalidomide-induced megakaryocytic differentiation leads to therapy resistance in del(5q) myelodysplastic syndrome	30
Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration	30
Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis	30
Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters	30
Apoptosis in the fetal testis eliminates developmentally defective germ cell clones	30
Dynamin-dependent vesicle twist at the final stage of clathrin-mediated endocytosis	30
Assembly of a persistent apical actin network by the formin Frl/Fmnl tunes epithelial cell deformability	30
Rear traction forces drive adherent tissue migration in vivo	29
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition	29
Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis	29
The spectrin cytoskeleton integrates endothelial mechanoresponses	29
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination	29
Phase separation of EB1 guides microtubule plus-end dynamics	29
Lysosome lipid signalling from the periphery to neurons regulates longevity	28
A p53–phosphoinositide signalosome regulates nuclear AKT activation	28
53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis	28
Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension	28
A guide to naming eukaryotic circular RNAs	28
Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells	27
Stalled replication fork protection limits cGAS–STING and P-body-dependent innate immune signalling	27
Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis	27
Opportunities and challenges in studying the extracellular vesicle corona	27
Sequential enhancer state remodelling defines human germline competence and specification	27
METALIC reveals interorganelle lipid flux in live cells by enzymatic mass tagging	27
ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection	27
A single-cell transcriptome atlas profiles early organogenesis in human embryos	27
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	27
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature	26
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair	26
Publisher Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation	26
YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis	26
Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation	26
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage	26
Optogenetic manipulation of cellular communication using engineered myosin motors	26
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation	26
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence	25
The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis	25
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics	25
LKB1 inactivation modulates chromatin accessibility to drive metastatic progression	25
Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids	25
Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection	25
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness	25
Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration	25
Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis	25
Monocytes deposit migrasomes to promote embryonic angiogenesis	25
Synthetic immunomodulation with a CRISPR super-repressor in vivo	25
A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	25