Nature Cell Biology

Article	Citations
Unravelling the endoplasmic reticulum–Golgi intermediate compartment in plant cells	992
tRNA flux and consistency in differentiation	399
COPIng with senescence	384
Restoring placental methylome	310
Finding a chaperone for TDP-43	250
Dynein upsizes under load	247
The guinea pig serves as an alternative model to study human preimplantation development	225
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication	221
Reinvigorating COTL1high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours	198
Ectosomes step forward in α-synuclein spread	197
ER-associated RNA silencing promotes ER quality control	192
Keeping membraneless organelles apart	190
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis	178
Criteria for the standardization of stem-cell-based embryo models	178
Designing protein-based artificial kinetochores as decoys to prevent meiotic errors in oocytes	168
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources	166
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function	155
Atlas of amnion development during the first trimester of human pregnancy	155
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription	151
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture	149
Compression-dependent microtubule reinforcement enables cells to navigate confined environments	148
A guideline on the molecular ecosystem regulating ferroptosis	145
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ	141
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells	140
How a ribosomal protein avoids mixed signals	139

Regenerating the academic pipeline	134
A serendipitous discovery of a family of membrane remodelling proteins	133
HSF1 renders NK cells too stressed to respond	131
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation	131
Implementing sustainable science in the lab	131
Nuclear class 3 PI3K coactivates circadian clock	131
Acidic niche sugar shield blocks ferroptosis	129
Real-time and programmable transcriptome sequencing with PROFIT-seq	118
Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1	115
Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth	111
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate	108
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis	107
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription	100
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise	100
TCF3, TCF12 and distinct enhancers regulate oocyte transcription	97
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration	95
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	94
Spermidine is essential for fasting-mediated autophagy and longevity	92
A lysosomal surveillance response to stress extends healthspan	92
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death	91
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	90
Mechanisms and functions of large extracellular vesicle biogenesis	89
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis	88
The nuclear shredder behind PARPi resistance	88
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates	87
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer	87
A cell biological perspective on Singapore’s scientific growth	85
Mitoxyperilysis as a distinct cell death type	85
Waste management and cell death in T cells	85
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification	83
Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs	82
Deep-learning for microscopy	82
It started with a western	82
Assessing gene loss after gene editing	81
A model for propagation of RNA structural memory through biomolecular condensates	80
Telomeres are a life-extending gift	80
Fat bolsters tumours against ferroptosis	79
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor	77
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities	77
Time for lipid cell biology	76
Tissue memory relies on stem cell priming in distal undamaged areas	75
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells	75
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system	73
Publisher Correction: Epigenetic programming by H3K23ac defines lineage fate of Meg3+ haematopoietic stem cells and drives immune ageing	73
Starving and crowded in quiescence	73
Escape from X inactivation is directly modulated by Xist noncoding RNA	72
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth	72
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome	71
Zippering against the beat	71
The role of PINK1–Parkin in mitochondrial quality control	71

MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes	70
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness	69
ATM counteracts chromatin-bound cGAS during DNA replication	69
Cellular mechanisms of brain lipid metabolism in health and disease	67
Aberrant amino acid-sensing promotes immunotherapy resistance via the inflammatory cytokine–ZBTB5–mTORC1 axis	67
Publisher Correction: SLC2A1+ tumour-associated macrophages spatially control CD8+ T cell function and drive resistance to immunotherapy in non-small-cell lung cancer	67
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions	66
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair	66
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity	66
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity	66
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development	65
Author Correction: Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution	65
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool	64
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	64
Cell-intrinsic and microenvironmental determinants of metastatic colonization	64
Phase separation of EB1 guides microtubule plus-end dynamics	64
Programmed mitophagy at the oocyte-to-zygote transition promotes lineage endurance	63
Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment	63
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming	62
The transcription factor GABPA is a master regulator of naive pluripotency	61
p53 increases phospholipid headgroup scavenging in senescence	61
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope	61
A foundation for tomorrow’s discoveries in cell biology	60
Keeping up with the Rag GTPases	60
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis	60
Author Correction: Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants	60
Publisher Correction: m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	59
Author Correction: Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	59
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung	58
CoCo-ST detects global and local biological structures in spatial transcriptomics datasets	58
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma	58
CAF heterogeneity and dynamics	57
Young secretory proteins go through a phase	57
Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis	57
Active size control of condensates by a kinase-based mechanism	57
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division	57
Revealing the order of chromatin reorganization events with Dam&ChIC	57
A guide to using embedded ethics in human stem-cell-based embryo model research	57
Autophagy-targeted NBR1–p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH	57
Proximal proteomics reveals a landscape of human nuclear condensates	56
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux	56
Mitochondrial YME1L1 governs unoccupied protein translocase channels	55
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes	55
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis	55
A milestone in epithelial–mesenchymal transition	55
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing	55
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation	54
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy	54
Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1	53
DNA nanodevices detect an acidic nanolayer on the lysosomal surface	53
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis	52
The molecular basis of human transcription-coupled DNA repair	52
Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma	52
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions	52
From phage genetics to chromosomes as mechanical objects	51
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression	51
Mapping T cell landscapes in B cell lymphomas	51
Author Correction: Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development	51
Conference accessibility should be a universal concern	51
Cell origin of BRCA2-mutant breast cancer	51
The proteomic landscape and temporal dynamics of human and mouse gastruloid development	50
ERCC6L2–CtIP condensation tunes end resection	50
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth	50
Fuelling basement membrane invasion	50
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels	50
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT	49
Spatial transcriptomic characterization of a Carnegie stage 7 human embryo	49
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	49
Shaping the composition of the mitochondrial outer membrane	49
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression	48
Modelling co-development between the somites and neural tube in human trunk-like structures	48
Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis	47
A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling	47
Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities	47
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion	46
Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction	46
Cancer-associated fibroblasts regulate DNA repair in pancreatic cancer through NDRG1-mediated R-loop processing	46
Diet and longevity	45
Arginyl-tRNA synthetase in inflammation	45
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells	45

Worrying through the ECM	45
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis	45
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling	44
Metabolites in tumour interstitial fluid directly suppress T cells	44
A bridge-like lipid transport protein controls plasma membrane lipid composition and fluidity	44
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis	44
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	44
Navigating human embryogenesis through tailored model selection	44
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases	43
Author Correction: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	43
Cracking glioblastoma core regulatory codes	43
Nuclear mechanics as a determinant of nuclear pore complex plasticity	43
Harnessing introns to monitor gene expression	43
From fallout to renewal	43
CD160 dictates anti-PD-1 immunotherapy resistance by regulating CD8+ T cell exhaustion in colorectal cancer	42
Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis	42
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier	42
Visualizing suborganellar lipid distribution using correlative light and electron microscopy	42
Ribophagy relies on Rpl12	42
Evidence for widespread cytoplasmic structuring into mesoscale condensates	41
In situ architecture of the human prohibitin complex	41
Stiff matrix induces exosome secretion to promote tumour growth	41
An expanding repertoire of E3 ligases in membrane Atg8ylation	41
The spectrin cytoskeleton integrates endothelial mechanoresponses	41
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation	40
ERO1a fosters glioblastoma aggressiveness and metabolic flexibility by regulating mitochondria-associated membrane dynamics	40
Author Correction: Stiff matrix induces exosome secretion to promote tumour growth	40
Membrane bridges and nanodomain partitioning govern membrane protein targeting to lipid droplets	40
Author Correction: Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain	40
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition	40
METTL3 restrains autoimmunity in β-cells	39
Order and disorder in clathrin-mediated endocytosis	39
Intrinsically disordered CO2 sensors	39
Target cell cortical tension regulates macrophage trogocytosis	39
Pausing pluripotency via RNA methylation	39
RNA sequestration in P-bodies sustains myeloid leukaemia	39
Morula-derived trophectoderm stem cells	38
Author Correction: SERRATE drives phase separation behaviours to regulate m6A modification and miRNA biogenesis	38
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes	38
FUS maintains TAZ fluidity and function	38
Tracking the fates of cystine in tumours	37
A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures	37
Neutrophil-derived migrasomes are an essential part of the coagulation system	37
Forcing cell fate	37
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers	36
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation	36
Programmable macromolecule delivery via engineered trogocytosis	36
Nuclear pores safeguard the integrity of the nuclear envelope	36
Author Correction: Spatial regulation of VEGF receptor endocytosis in angiogenesis	36
Author Correction: DNA nanodevices detect an acidic nanolayer on the lysosomal surface	36
Celebrating 25 years of cell biology	36
RNA-specific local translation is patterned by condensates for multinucleate cell growth	36
Lipidomes define immune cell identity	35
Remote control of AMPK via extracellular adenosine controls tissue growth	35
Breaking up translation condensates in cancer	35
Crossover patterning through condensation and coarsening of pro-crossover factors	34
Sugar unmasking for trafficking	34
Boosting cargo turnover with receptor mobility	34
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos	34
Ex vivo imaging reveals the spatiotemporal control of ovulation	34
Sperm bud mitochondria to adjust the numbers	34
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection	34
A new cell in an old tactile sensory organ	34
RNA-binding proteins pull in chromatin loops	34
Diffusing caveolin-1 scaffolds regulate mechanosignalling	33
Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability	33
Gender equity: toward redefining values	33
Retinoic acid induces human gastruloids with posterior embryo-like structures	33
Role of vinculin in metabolism	33
Spatial profiling in bladder cancer	33
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing	33
Sperm miRNAs exercise benefits	33
NAD+ regulates nucleotide metabolism and genomic DNA replication	32
A comprehensive tRNA pseudouridine map uncovers targets dependent on human stand-alone pseudouridine synthases	32
Harnessing lysohormesis for healthy ageing	32
TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells	32
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules	32
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites	32
Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants	32
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability	32
RNA scaffolds the Golgi ribbon by forming condensates with GM130	32
Nucleophagy removes cytotoxic trapped PARP1	31
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins	31
Alu RNAs organize transcription at speckles	31
Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma	31
In situ cryo-ET defines the ultrastructure of ER exit sites in human cells	31
Lessons from infrastructure and research advocacy in India	31
Combinatorial selective ER-phagy remodels the ER during neurogenesis	31
Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer’s brains	31
Grow up, beta cells	30
Profiling cell death in COVID-19 pathology	30
PTEN checkMAITs type-17 innate-like T cells	30
Now is the greatest time to be in it	30
Host protection by two memory-like MAIT subsets	30
Cytoplasmic control of spindle architecture	30