Nature Cell Biology

Article	Citations
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis	438
Telomere dysfunction in ageing and age-related diseases	291
PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis	262
Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker	261
Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression	248
CRISPR technologies for precise epigenome editing	245
Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling	214
Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	208
Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity	184
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis	169
ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration	144
PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications	138
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control	136
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells	135
Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration	130
Evaluating totipotency using criteria of increasing stringency	127
Liquid-like protein interactions catalyse assembly of endocytic vesicles	123
A single-cell transcriptomic landscape of the lungs of patients with COVID-19	122
Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity	119
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression	114
Metabolic communication in the tumour–immune microenvironment	113
R-loops as Janus-faced modulators of DNA repair	113
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA	112
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis	111
The STING phase-separator suppresses innate immune signalling	111

Autophagosome biogenesis comes out of the black box	110
Cell fate coordinates mechano-osmotic forces in intestinal crypt formation	109
Generic nature of the condensed states of proteins	108
Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses	106
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age	106
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis	104
Phase separation of SERRATE drives dicing body assembly and promotes miRNA processing in Arabidopsis	102
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells	102
LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy	99
Depletion of aneuploid cells in human embryos and gastruloids	98
Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress	96
m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype	93
The chromatin remodeler DDM1 prevents transposon mobility through deposition of histone variant H2A.W	93
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance	91
Membrane surfaces regulate assembly of ribonucleoprotein condensates	91
Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses	90
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin	89
Exploring the expanding universe of small RNAs	89
An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer	89
Mechanical force application to the nucleus regulates nucleocytoplasmic transport	86
Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock	81
METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis	81
Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling	81
TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis	81
Cell type ontologies of the Human Cell Atlas	80
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis	78
A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression	75
Anatomical structures, cell types and biomarkers of the Human Reference Atlas	75
Control of endothelial quiescence by FOXO-regulated metabolites	74
Stiff matrix induces exosome secretion to promote tumour growth	73
Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development	72
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung	72
Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19	71
POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis	70
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	69
Proteotoxic stress is a driver of the loser status and cell competition	69
Human melanocyte development and melanoma dedifferentiation at single-cell resolution	69
Spatial organization of transcribed eukaryotic genes	68
Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis	68
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia	67
Nucleotide imbalance decouples cell growth from cell proliferation	67
Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning	67
Deadly actin collapse by disulfidptosis	66
An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory	65
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes	65
A PRC2-independent function for EZH2 in regulating rRNA 2′-O methylation and IRES-dependent translation	64
The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels	63
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing	63
Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome	61
Heat stress activates YAP/TAZ to induce the heat shock transcriptome	61

Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues	60
Eosinophil extracellular traps drive asthma progression through neuro-immune signals	60
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	59
Functional mechanisms and abnormalities of the nuclear lamina	59
Cell cycle-specific phase separation regulated by protein charge blockiness	59
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability	58
Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility	58
Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations	58
Monocytes deposit migrasomes to promote embryonic angiogenesis	57
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function	56
Multiplexed genome regulation in vivo with hyper-efficient Cas12a	55
Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation	55
Metabolic determination of cell fate through selective inheritance of mitochondria	55
A single-cell transcriptome atlas profiles early organogenesis in human embryos	54
Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration	54
ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation	54
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2	54
Epithelial cell plasticity drives endoderm formation during gastrulation	53
Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks	53
The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin	53
Recycling of autophagosomal components from autolysosomes by the recycler complex	52
Illuminating RNA biology through imaging	52
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling	52
Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition	52
Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates	52
The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming	51
Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence	51
Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death	51
A guide to naming eukaryotic circular RNAs	51
Single-cell atlas of human liver development reveals pathways directing hepatic cell fates	51
Cohesin regulates homology search during recombinational DNA repair	50
ATG9A protects the plasma membrane from programmed and incidental permeabilization	50
Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration	50
Global profiling of RNA-binding protein target sites by LACE-seq	49
Phosphatidylinositol 3-kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4	49
Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth	49
Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea	49
A reversible shearing DNA probe for visualizing mechanically strong receptors in living cells	49
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)	48
Untangling the web of intratumour heterogeneity	48
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence	48
Opportunities and challenges in studying the extracellular vesicle corona	47
RETRACTED ARTICLE: CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling	47
Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain	44
LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria	44
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth	44
Dissecting OCT4 defines the role of nucleosome binding in pluripotency	44
E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis	43
Mammalian genome innovation through transposon domestication	43
Phase separation of EB1 guides microtubule plus-end dynamics	43
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation	43
Identification of two pathways mediating protein targeting from ER to lipid droplets	43
LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy	42
A p53–phosphoinositide signalosome regulates nuclear AKT activation	42
Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids	42
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition	42
YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis	42
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity	42
Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors	41
Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements	41
Rear traction forces drive adherent tissue migration in vivo	41
Dynamin-dependent vesicle twist at the final stage of clathrin-mediated endocytosis	41
Temporal and spatial topography of cell proliferation in cancer	40
A biomechanical switch regulates the transition towards homeostasis in oesophageal epithelium	40
Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction	39
The piRNA pathway is essential for generating functional oocytes in golden hamsters	39
Reciprocal regulation of chaperone-mediated autophagy and the circadian clock	39
A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers	39
Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage	38
Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension	38
Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly	38
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination	38
Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis	38
Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration	38
Substoichiometric action of long noncoding RNAs	38
Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs	38
The spectrin cytoskeleton integrates endothelial mechanoresponses	38
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair	37
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage	37
CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells	37

Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration	37
Apoptosis in the fetal testis eliminates developmentally defective germ cell clones	36
dCas9-based gene editing for cleavage-free genomic knock-in of long sequences	36
Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis	36
Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis	36
Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells	35
Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer	35
METALIC reveals interorganelle lipid flux in live cells by enzymatic mass tagging	35
Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters	35
Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation	35
Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space	35
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics	35
Lysosome lipid signalling from the periphery to neurons regulates longevity	35
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness	34
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity	34
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells	34
Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells	33
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	33
The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis	32
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence	32
LKB1 inactivation modulates chromatin accessibility to drive metastatic progression	32
The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets	32
Sequential enhancer state remodelling defines human germline competence and specification	32
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation	31
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer	31
ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection	31
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities	31
53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis	31
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool	31
Stalled replication fork protection limits cGAS–STING and P-body-dependent innate immune signalling	31
Super-resolved 3D tracking of cargo transport through nuclear pore complexes	30
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation	30
Proton-gated anion transport governs macropinosome shrinkage	30
A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	29
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system	29
Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors	29
Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic cell development	28
MLL3 loss drives metastasis by promoting a hybrid epithelial–mesenchymal transition state	28
Lysate-based pipeline to characterize microtubule-associated proteins uncovers unique microtubule behaviours	28
Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma	28
Optogenetic manipulation of cellular communication using engineered myosin motors	28
Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells	27
Perinatal angiogenesis from pre-existing coronary vessels via DLL4–NOTCH1 signalling	27
The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1	27
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth	27
CDK1–cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry	27
A guideline on the molecular ecosystem regulating ferroptosis	27
Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila	26
The intrinsically disordered region from PP2C phosphatases functions as a conserved CO2 sensor	26
Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis	26
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis	26
Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay	26
Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway	26
KCNQ1OT1 promotes genome-wide transposon repression by guiding RNA–DNA triplexes and HP1 binding	25
Monocyte and dendritic cell defects in COVID-19	25
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis	25
Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection	25
Insights and opportunities at the crossroads of cancer and neuroscience	25
Remodelling of oxygen-transporting tracheoles drives intestinal regeneration and tumorigenesis in Drosophila	25
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase	25
ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells	25
Enhancer selection dictates gene expression responses in remote organs during tissue regeneration	24
ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels	24
The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function	24
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes	24
STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2	24
A lysosome membrane regeneration pathway depends on TBC1D15 and autophagic lysosomal reformation proteins	23
FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance	23
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins	23
Profiling and promise of supermeres	23
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	23
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT	23
Adiponectin receptors sustain haematopoietic stem cells throughout adulthood by protecting them from inflammation	23
Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability	23
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication	23
VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells	23
The conserved helicase ZNFX-1 memorializes silenced RNAs in perinuclear condensates	22
Aggresome assembly at the centrosome is driven by CP110–CEP97–CEP290 and centriolar satellites	22
The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A	22
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1	22
LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion	22
Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids	22
An atlas of rabbit development as a model for single-cell comparative genomics	22
Lipid droplets and cellular lipid flux	22
TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation	22
Stomach-derived human insulin-secreting organoids restore glucose homeostasis	22
Multivalency ensures persistence of a +TIP body at specialized microtubule ends	21
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition	21
Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair	21
NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency	21
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites	21
Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo	21
Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis	20
Elucidating minimal residual disease of paediatric B-cell acute lymphoblastic leukaemia by single-cell analysis	20
A monoastral mitotic spindle determines lineage fate and position in the mouse embryo	20