OOIR: Observatory of International Research

Papers

(The median citation count of International Journal of Biological Sciences is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-03-01 to 2025-03-01.)

Article	Citations
Crosstalk between PML and p53 in response to TGF-β1: A new mechanism of cardiac fibroblast activation	163
IFNAR(-/-) Mice Constitute a Suitable Animal Model for Epizootic Hemorrhagic Disease Virus Study and Vaccine Evaluation	146
PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry	145
Targeting Type I Interferon Induction and Signaling: How Zika Virus Escapes from Host Innate Immunity	133
Digging out MDIG from the mess of H3K9me3, OTX2 and MYC signaling in human cancers	102
Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma	90
Broadening horizons: the multifaceted functions of ferroptosis in kidney diseases	90
Role Of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer	89
Engineering neoantigen vaccines to improve cancer personalized immunotherapy	88
LncRNA-COX2 inhibits Fibroblast Activation and Epidural Fibrosis by Targeting EGR1	86
The Essential Role of Angiogenesis in Adenosine 2A Receptor Deficiency-mediated Impairment of Wound Healing Involving c-Ski via the ERK/CREB Pathways	79
As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma	79
Inhibition of α4β1 Integrin Activity by Small Tellurium Compounds Regulates PD-L1 Expression and Enhances Antitumor Effects	77
Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice	76
Enhancing mitophagy by ligustilide through BNIP3-LC3 interaction attenuates oxidative stress-induced neuronal apoptosis in spinal cord injury	74
FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma	73
Targeting METTL3 enhances the chemosensitivity of non-small cell lung cancer cells by decreasing ABCC2 expression in an m⁶A-YTHDF1-dependent manner	70
Erratum for Ferroptosis-related Genes for Overall Survival Prediction in Patients with Colorectal Cancer can be Inhibited by Gallic acid	69
Neuraminidase 1 deficiency attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory via AMPK-SIRT3 pathway in diabetic cardiomyopathy mice	67
The dysadherin/FAK axis promotes individual cell migration in colon cancer	64
Uncovering a Novel Functional Interaction Between Adult Hepatic Progenitor Cells, Inflammation and EGFR Signaling During Bile Acids-Induced Injury	64
A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer	62
Exploring viral mimicry combined with epigenetics and tumor immunity: new perspectives in cancer therapy	59
Regulation of nitric oxide generation and consumption	59
Traditional Chinese Medicine for Viral Pneumonia Therapy: Pharmacological Basis and Mechanistic Insights	57

Chloroquine Suppresses Colorectal Cancer Progression via Targeting CHKA and PFKM to inhibit the PI3K/AKT Pathway and the Warburg Effect	57
SEC61G Facilitates Brain Metastases via Antagonizing PGAM1 Ubiquitination and Immune Microenvironment Remodeling in Non-Small Cell Lung Cancer	56
Advancement Opportunities and Endeavor of Innovative Targeted Therapies for Small Cell Lung Cancer	56
Targeting ferroptosis to enhance the efficacy of mesenchymal stem cell-based treatments for intervertebral disc degeneration	55
Downregulation of PGAM2 alleviates angiotensin II-induced cardiac hypertrophy by destabilizing HSP90 and inactivating the mTOR/IKKα signaling pathway	54
SMURF2 facilitates ubiquitin-mediated degradation of ID2 to attenuate lung cancer cell proliferation	53
Cancer can be a purely epigenetic disorder	53
Molecular mechanisms of pyroptosis and its role in anti-tumor immunity	52
Loss of DDRGK1 impairs IRE1α UFMylation in spondyloepiphyseal dysplasia	49
Dendropanoxide Alleviates Thioacetamide-induced Hepatic Fibrosis via Inhibition of ROS Production and Inflammation in BALB/_C Mice	48
Dysregulation of Transglutaminase type 2 through GATA3 defines aggressiveness and Doxorubicin sensitivity in breast cancer	47
Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism	46
COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2	45
Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury	44
Regulation of CD38 on Multiple Myeloma and NK Cells by Monoclonal Antibodies	43
Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?	43
Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma: Erratum	41
Nicotinamide adenine dinucleotide kinase promotes lymph node metastasis of NSCLC via activating ID1 expression through BMP pathway	41
Smoke-induced SAV1 Gene Promoter Hypermethylation Disrupts YAP Negative Feedback and Promotes Malignant Progression of Non-small Cell Lung Cancer	41
S100A4 Is a Key Facilitator of Thoracic Aortic Dissection	40
FBXO22 Suppresses Metastasis in Human Renal Cell Carcinoma via Inhibiting MMP-9-Mediated Migration and Invasion and VEGF-Mediated Angiogenesis	40
Humoral and Cellular Immune Responses of COVID-19 vaccines against SARS-Cov-2 Omicron variant: a systemic review	40
Crosstalk of ubiquitin system and non-coding RNA in fibrosis	40
NOP2-mediated 5-methylcytosine modification of APOL1 messenger RNA activates PI3K-Akt and facilitates clear cell renal cell carcinoma progression	40
Rebalancing TGF-β/PGE₂ breaks RT-induced immunosuppressive barriers by enhancing tumor-infiltrated dendritic cell homing	39
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells	39
Antioxidant genes in cancer and metabolic diseases: Focusing on Nrf2, Sestrin, and heme oxygenase 1	39
Nlp-dependent ER-to-Golgi transport	39
Transcription Factor E2F4 Promote Proliferation, Migration, and Invasion of Gastric Cancer Cells by transcriptionally activating DSCC1	39
Integrated pathological analysis to develop a Gal-9 based immune survival stratification to predict the outcome of lung large cell neuroendocrine carcinoma and its usefulness in immunotherapy	38
MKL-1 suppresses ferroptosis by activating system Xc- and increasing glutathione synthesis	38
Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients	38
Single-cell transcriptomics reveals zinc and copper ions homeostasis in epicardial adipose tissue of heart failure	38
Selective targeting of the TLR4 co-receptor, MD2, prevents colon cancer growth and lung metastasis: Erratum	38
BRD4 Inhibitor AZD5153 Suppresses the Proliferation of Colorectal Cancer Cells and Sensitizes the Anticancer Effect of PARP Inhibitor: Erratum	36
Myeloid cell-expressed MNDA enhances M2 polarization to facilitate the metastasis of hepatocellular carcinoma	36
Tectorigenin targets PKACα to promote GLUT4 expression in skeletal muscle and improve insulin resistance in vitro and in vivo	36
Lipid homeostasis in diabetic kidney disease	35
Novel insights into m⁶A modification of coding and non-coding RNAs in tumor biology: From molecular mechanisms to therapeutic significance	35
Epsti1 Regulates the Inflammatory Stage of Early Muscle Regeneration through STAT1-VCP Interaction	35
Itga5-PTEN signaling regulates striatal synaptic strength and motor coordination in Parkinson's disease	35
Cerebral microinfarct is emergency consequence of Alzheimer's disease: a new insight into development of neurodegenerative diseases	35
Target deubiquitinase OTUB1 as a therapeatic strategy for BLCA via β-catenin/necroptosis signal pathway	35
High dietary Fructose Drives Metabolic Dysfunction-Associated Steatotic Liver Disease via Activating ubiquitin-specific peptidase 2/11β-hydroxysteroid dehydrogenase type 1 Pathway in Mice	35
Ebastine exerts antitumor activity and induces autophagy by activating AMPK/ULK1 signaling in an IPMK-dependent manner in osteosarcoma	34
Olfactomedin-4 deletion exacerbates DSS-induced colitis through a matrix metalloproteinase-9-dependent mechanism	34
Squalene epoxidase/SQLE is a candidate target for treatment of colorectal cancers with p53 mutation and elevated c-MYC expression	34
Targeting metabolism in aortic aneurysm and dissection: from basic research to clinical applications	34
Exercise maintains bone homeostasis by promoting osteogenesis through STAT3	33
Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers	33

Circular RNA hsa_circ_0003823 promotes the Tumor Progression, Metastasis and Apatinib Resistance of Esophageal Squamous Cell Carcinoma by miR-607/CRISP3 Axis	32
N⁶-Methyladenosine Modification of ANLN Enhances Hepatocellular Carcinoma Bone Metastasis	32
Recipients of COVID-19 vaccines face challenges of SARS-CoV-2 variants	31
The ADAM9/WISP-1 axis cooperates with osteoblasts to stimulate primary prostate tumor growth and metastasis	31
Apolipoproteins as potential communicators play an essential role in the pathogenesis and treatment of early atherosclerosis	31
The interactions between integrin α₅β₁ of liver cancer cells and fibronectin of fibroblasts promote tumor growth and angiogenesis	31
Conjugate of ibrutinib with a TLR7 agonist suppresses melanoma progression and enhances antitumor immunity	30
SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer	30
Regulation of lung epithelial cell senescence in smoking-induced COPD/emphysema by microR-125a-5p via Sp1 mediation of SIRT1/HIF-1a	30
p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer	30
Minocycline binds and inhibits LYN activity to prevent STAT3-meditated metastasis of colorectal cancer	30
PPDPF Promotes the Progression and acts as an Antiapoptotic Protein in Non-Small Cell Lung Cancer	29
The homeoprotein HOXB2 limits triple-negative breast carcinogenesis via extracellular matrix remodeling	29
Dysregulated Ribosome Biogenesis Is a Targetable Vulnerability in Triple-Negative Breast Cancer: MRPS27 as a Key Mediator of the Stemness-inhibitory Effect of Lovastatin	29
Aberrant Expression of SLC7A11 Impairs the Antimicrobial Activities of Macrophages in Staphylococcus Aureus Osteomyelitis in Mice	29
DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1 Therapy	29
CYSLTR1 antagonist inhibits Th17 cell differentiation by regulating the NF-κB signaling for the treatment of psoriasis	29
Advances in the multi-omics landscape of follicular lymphoma	28
PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer	28
Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, Pharmacological Modulation, and Lifestyle Medicine	28
Neutrophil extracellular traps mediate m⁶A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells	28
Clinical and biochemical characteristics of 12 Chinese primary hypertrophic osteoarthropathy patients with HPGD mutations	28
Stearoyl-CoA Desaturase-1 dependent lipid droplets accumulation in cancer-associated fibroblasts facilitates the progression of lung cancer	28
Comprehensive Histopathology Imaging in Pancreatic Biopsies: High Definition Infrared Imaging with Machine Learning Approach	28
Cancer-associated fibroblasts promote migration and invasion of non-small cell lung cancer cells via METTL3-mediated RAC3 m⁶A modification	28
Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance	28
Ascorbic acid induced TET2 enzyme activation enhances cancer immunotherapy efficacy in renal cell carcinoma	28
Unraveling Colorectal Cancer and Pan-cancer Immune Heterogeneity and Synthetic Therapy Response Using Cuproptosis and Hypoxia Regulators by Multi-omic Analysis and Experimental Validation	28
Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway	27
Dynamics of the gut-liver axis in rats with varying fibrosis severity	27
The sphingosine kinase inhibitor SKI-V suppresses cervical cancer cell growth	27
MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy	27
XPOT Disruption Suppresses TNBC Growth through Inhibition of Specific tRNA Nuclear Exportation and TTC19 Expression to Induce Cytokinesis Failure	27
Downregulation of SEPTIN5 inhibits prostate cancer progression by increasing CD8⁺ T cell infiltration	27
Gli1 promotes the phenotypic transformation of valve interstitial cells through Hedgehog pathway activation exacerbating calcific aortic valve disease	27
A novel lncRNA-mediated epigenetic regulatory mechanism in periodontitis	26
HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR inhibitors through the ETS1-FKBP12 axis	26
mTOR Signaling: Roles in Hepatitis B Virus Infection and Hepatocellular Carcinoma	26
PPARγ Agonist Pioglitazone Prevents Hypoxia-induced Cardiac Dysfunction by Reprogramming Glucose Metabolism	25
Single-cell resolution reveals RalA GTPase expanding hematopoietic stem cells and facilitating of BCR-ABL1-driven leukemogenesis in a CRISPR/Cas9 gene editing mouse model	25
Neutrophils promote tumor invasion via FAM3C-mediated epithelial-to-mesenchymal transition in gastric cancer	25
METTL16 Promotes Stability of SYNPO2L mRNA and leading to Cancer Cell Lung Metastasis by Secretion of COL10A1 and attract the Cancer-Associated Fibroblasts	25
The Antitumor and Sorafenib-resistant Reversal Effects of Ursolic Acid on Hepatocellular Carcinoma via Targeting ING5	25
Uncovering the flip side of immune checkpoint inhibitors: a comprehensive review of immune-related adverse events and predictive biomarkers	25
Catalpol attenuates hepatic glucose metabolism disorder and oxidative stress in triptolide-induced liver injury by regulating the SIRT1/HIF-1α pathway	25
N-Acetylcysteine overcomes epalrestat-mediated increase of toxic 4-hydroxy-2-nonenal and potentiates the anti-arthritic effect of epalrestat in AIA model	25
Development of Advanced Oral-on-a-Chip: Replicating the Intricate Human Oral Microenvironment	24
MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism	24
TBK1 Facilitates GLUT1-Dependent Glucose Consumption by suppressing mTORC1 Signaling in Colorectal Cancer Progression	24
Nε-(1-Carboxymethyl)-L-lysine/RAGE Signaling Drives Metastasis and Cancer Stemness through ERK/NFκB axis in Osteosarcoma	24
Syntaxin-6 promotes the progression of hepatocellular carcinoma and alters its sensitivity to chemotherapies by activating the USF2/LC3B axis	24
MiR-138-5p Targets MACF1 to Aggravate Aging-related Bone Loss	24
COVID-19 Pandemic: Insights into Interactions between SARS-CoV-2 Infection and MAFLD	24
Tumor Microenvironment and its Implications for Antitumor Immunity in Cholangiocarcinoma: Future Perspectives for Novel Therapies	24
Brain-derived extracellular vesicles promote bone-fat imbalance in Alzheimer's disease	23
NUSAP1 is Upregulated by Estrogen to Promote Lung Adenocarcinoma Growth and Serves as a Therapeutic Target	23
Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease	23
Reconstruction of the Hepatic Microenvironment and Pathological Changes Underlying Type II Diabetes through Single-Cell RNA Sequencing	23
Exploring the Mechanism of Ferroptosis Induction by Sappanone A in Cancer: Insights into the Mitochondrial Dysfunction Mediated by NRF2/xCT/GPX4 Axis	23
Integrated analysis of tumor and adjacent non-tumor proteomic data reveals SERPINH1 as a recurrence biomarker and drug target in hepatocellular carcinoma	23
SIRT1 Mediates the Antagonism of Wnt/β-Catenin Pathway by Vitamin D in Colon Carcinoma Cells	23
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer	22
HPV E6/E7 promotes aerobic glycolysis in cervical cancer by regulating IGF2BP2 to stabilize m⁶A-MYC expression	22
Cold atmospheric plasma potentiates ferroptosis via EGFR(Y1068)-mediated dual axes on GPX4 among triple negative breast cancer cells	22
Caveolin-1 mitigates the advancement of metabolic dysfunction-associated steatotic liver disease by reducing endoplasmic reticulum stress and pyroptosis through the restoration of cholesterol homeosta	22
Protection of c-Fos from autophagic degradation by PRMT1-mediated methylation fosters gastric tumorigenesis	22
HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca²⁺-FOXO1 pathway	22
Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy	22
Tubulointerstitial nephritis antigen-like 1 promotes the progression of liver fibrosis after HCV eradication with direct-acting antivirals	22
TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver disease via nitric oxide production	22
Photodynamic Therapy for Inflammatory and Cancerous Diseases of the Intestines: Molecular Mechanisms and Prospects for Application	22
Influence of Microbiota on Tumor Immunotherapy	22
Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation	22
The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis In Vitro and In Vivo	22
Extracellular vesicles, the emerging mirrors of brain physiopathology	21
Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis: Erratum	21
The role of CREG1 in megakaryocyte maturation and thrombocytopoiesis	21
RNA-binding motif protein 10 represses tumor progression through the Wnt/β- catenin pathway in lung adenocarcinoma	21
Lingo1 in the hippocampus contributes to cognitive dysfunction after anesthesia and surgery in aged mice	21
Atrial Natriuretic Peptide Attenuates Colitis via Inhibition of the cGAS-STING Pathway in Colonic Epithelial Cells	21

N-glycosylation-mediated CD147 accumulation induces cardiac fibrosis in the diabetic heart through ALK5 activation	21
Fibroblast-like cells Promote Wound Healing via PD-L1-mediated Inflammation Resolution	21
Extracellular Vesicles in Bone Homeostasis: Emerging Mediators of Osteoimmune Interactions and Promising Therapeutic Targets	21
Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice	21
SNAIL Induces EMT and Lung Metastasis of Tumours Secreting CXCL2 to Promote the Invasion of M2-Type Immunosuppressed Macrophages in Colorectal Cancer	20
HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation	20
Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway	20
Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis	20
Multi-Omics profiling identifies aldehyde dehydrogenase 2 as a critical mediator in the crosstalk between Treg-mediated immunosuppression microenvironment and hepatocellular carcinoma	20
Effect Of XBP1 Deficiency In Cartilage On The Regulatory Network Of LncRNA/circRNA-miRNA-mRNA	20
Clinical Implementation of Rare and Novel DPYD Variants for Personalizing Fluoropyrimidine Treatment: Challenges and Opportunities	20
IGF2BP3 Regulates TMA7-mediated Autophagy and Cisplatin Resistance in Laryngeal Cancer via m6A RNA Methylation	20
Integrating Spatial Transcriptomics and Single-nucleus RNA Sequencing Reveals the Potential Therapeutic Strategies for Uterine Leiomyoma	20
The FGFR1 Signaling Pathway Upregulates the Oncogenic Transcription Factor FOXQ1 to Promote Breast Cancer Cell Growth	20
Inhibition of the HMGB1/RAGE axis protects against cisplatin-induced ototoxicity via suppression of inflammation and oxidative stress	19
TMEM105 modulates disulfidptosis and tumor growth in pancreatic cancer via the β-catenin-c-MYC-GLUT1 axis	19
Prolonged DEHP exposure enhances the stemness and metastatic potential of TNBC cells in an MSI2-dependent manner	19
Enhanced tumor immunotherapy by polyfunctional CD19-CAR T cells engineered to secrete anti-CD47 single-chain variable fragment	19
Febuxostat therapy improved the outcomes of cardiorenal syndrome rodent through alleviating xanthine oxidase-induced oxidative stress and mitochondrial dysfunction	19
Fatty Acid Trafficking Between Lipid Droplets and Mitochondria: An Emerging Perspective	19
eNAMPT/Ac-STAT3/DIRAS2 Axis Promotes Development and Cancer Stemness in Triple-Negative Breast Cancer by Enhancing Cytokine Crosstalk Between Tumor-Associated Macrophages and Cancer Cells	19
P2RY13 Exacerbates Intestinal Inflammation by Damaging the Intestinal Mucosal Barrier via Activating IL-6/STAT3 Pathway	19
Decreased methylation of ZNF671 suppresses tumor progression by promoting MAPK6 transcription in laryngeal carcinoma	18
B.1.617.2 (Delta) Variant of SARS-CoV-2: features, transmission and potential strategies	18
Deubiquitinase USP13 regulates glycolytic reprogramming and progression in osteosarcoma by stabilizing METTL3/m⁶A/ATG5 axis	18
RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes	18
Functional and Structural Diversity of Insect Glutathione S-transferases in Xenobiotic Adaptation	18
Keap-NRF2 signaling contributes to the Notch1 protected heart against ischemic reperfusion injury via regulating mitochondrial ROS generation and bioenergetics	18
CTSG Suppresses Colorectal Cancer Progression through Negative Regulation of Akt/mTOR/Bcl2 Signaling Pathway	18
Pantothenate Kinase 1 Inhibits the Progression of Hepatocellular Carcinoma by Negatively Regulating Wnt/β-catenin Signaling	18
Novel insights into the interplay between m6A modification and programmed cell death in cancer	18
LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis	17
Emerging roles of lncRNA in Nasopharyngeal Carcinoma and therapeutic opportunities	17
Smad3 Signatures in Renal Inflammation and Fibrosis	17
Mesenchymal stem cell-derived extracellular vesicles accelerate diabetic wound healing by inhibiting NET-induced ferroptosis of endothelial cells	17
Oncogenic RARγ isoforms promote head and neck cancer proliferation through vinexin-β-mediated cell cycle acceleration and autocrine activation of EGFR signal	17
MicroRNA-495 Modulates Neuronal Layer Fate Determination by Targeting Tcf4	17
O-GlcNAcylation of ZEB1 facilitated mesenchymal pancreatic cancer cell ferroptosis	17
The cross-talk between PARylation and SUMOylation in C/EBPβ at K134 site participates in pathological cardiac hypertrophy	17
Gamma synuclein promotes cancer metastasis through the MKK3/6-p38MAPK cascade	17
The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m⁶A readers in cancer	17
Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection	17
Impact of KRAS mutation on the tumor microenvironment in colorectal cancer	17
The Neuroprotective Effects of Caffeine in a Neonatal Hypoxia-Ischemia Model are Regulated through the AMPK/mTOR Pathway	17
Extracellular Vesicles from Human Induced Pluripotent Stem Cells Exhibit a Unique MicroRNA and CircRNA Signature	17
AKAP1 contributes to impaired mtDNA replication and mitochondrial dysfunction in podocytes of diabetic kidney disease	17
CXCL12-CXCR4/CXCR7 Axis in Cancer: from Mechanisms to Clinical Applications	17
The role of intestinal microbiota and its metabolites in intestinal and extraintestinal organ injury induced by intestinal ischemia reperfusion injury	17
Downregulation of PPARα mediates FABP1 expression, contributing to IgA nephropathy by stimulating ferroptosis in human mesangial cells	17
Hypoxia-induced exosomes facilitate lung pre-metastatic niche formation in hepatocellular carcinoma through the miR-4508-RFX1-IL17A-p38 MAPK-NF-κB pathway	17
SCGN recruits macrophages by regulating chemokine secretion in clear cell renal cell carcinoma	17
The Quiet Giant: Identification, Effectors, Molecular Mechanism, Physiological and Pathological Function in mRNA 5-methylcytosine Modification	17
Coenzyme Q₀ inhibited the NLRP3 inflammasome, metastasis/EMT, and Warburg effect by suppressing hypoxia-induced HIF-1α expression in HNSCC cells	16
Vitamin D Promotes Remyelination by Suppressing c-Myc and Inducing Oligodendrocyte Precursor Cell Differentiation after Traumatic Spinal Cord Injury	16
The Burgeoning Significance of Liquid-Liquid Phase Separation in the Pathogenesis and Therapeutics of Cancers	16
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases	16
Disulfidptosis: Six Riddles Necessitating Solutions	16
EFEMP2 suppresses epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in human bladder cancer: Erratum	16
METTL3 boosts mitochondrial fission and induces cardiac fibrosis after ischemia/reperfusion injury	16
Nuclear Softness Promotes the Metastatic Potential of Large-Nucleated Colorectal Cancer Cells via the ErbB4-Akt1-Lamin A/C Signaling Pathway	16
Extracellular Vesicles in Mental Disorders: A State-of-art Review	16
Multimerization of the GATA4 transcription factor regulates transcriptional activity and cardiomyocyte hypertrophic response	16
Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target	16
Identification of Gαi3 as a promising target for osteosarcoma treatment	16
Spatiotemporal quantification of metastatic tumour cell growth and distribution in lymph nodes by whole-mount tissue 3D imaging	16
Cx43 deficiency confers EMT-mediated tamoxifen resistance to breast cancer via c-Src/PI3K/Akt pathway: Erratum	16
Interstitial Fluid Shear Stress Induces the Synthetic Phenotype Switching of VSMCs to Release Pro-calcified Extracellular Vesicles via EGFR-MAPK-KLF5 Pathway	16
Platelet-derived extracellular vesicles inhibit ferroptosis and promote distant metastasis of nasopharyngeal carcinoma by upregulating ITGB3	16
The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease	16
Involvement of miR-619-5p in resistance to cisplatin by regulating ATXN3 in oral squamous cell carcinoma: Erratum	16
Identification and Characterization of Alcohol-related Hepatocellular Carcinoma Prognostic Subtypes based on an Integrative N6-methyladenosine methylation Model: Erratum	16
Single-Cell RNA-Sequencing Identifies Bone Marrow-Derived Progenitor Cells as a Main Source of Extracellular Matrix-Producing Cells Across Multiple Organ-Based Fibrotic Diseases	16
Protein arginine methyltransferase 1 is required for the maintenance of adult small intestinal and colonic epithelial cell homeostasis	15
WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives Cellular Senescence by Upregulating IRF8	15
Exogenous α-ketoglutarate Modulates Redox Metabolism and Functions of Human Dendritic Cells, Altering Their Capacity to Polarise T Cell Response	15
Protein Arginine Methyltransferases Refine the Classification of Clear Cell Renal Cell Carcinoma with Distinct Prognosis and Tumor Microenvironment Characteristics	15
Platelet-derived extracellular vesicles aggravate septic acute kidney injury via delivering ARF6	15
SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis	15
MiR-206 suppresses the deterioration of intrahepatic cholangiocarcinoma and promotes sensitivity to chemotherapy by inhibiting interactions with stromal CAFs: Erratum	15
Ferroptosis: the balance between death and survival in colorectal cancer	15
Towards improving the prognosis of stroke through targeting the circadian clock system	15
Mir-484 contributes to diminished ovarian reserve by regulating granulosa cell function via YAP1-mediated mitochondrial function and apoptosis: Erratum	15
CD151 promotes Colorectal Cancer progression by a crosstalk involving CEACAM6, LGR5 and Wnt signaling via TGFβ1: Erratum	15
Neurotrophin3 promotes hepatocellular carcinoma apoptosis through the JNK and P38 MAPK pathways	15
Rab31 promotes the invasion and metastasis of cervical cancer cells by inhibiting MAPK6 degradation	15
Insight of Autophagy in Spontaneous Miscarriage	15
Inhibitory role of TRIP-Br1 oncoprotein in anticancer drug-mediated programmed cell death via mitophagy activation	15
Stella Regulates the Development of Female Germline Stem Cells by Modulating Chromatin Structure and DNA Methylation	15
The scheme, and regulative mechanism of pyroptosis, ferroptosis, and necroptosis in radiation injury	15
Pgam5-mediated PHB2 dephosphorylation contributes to endotoxemia-induced myocardial dysfunction by inhibiting mitophagy and the mitochondrial unfolded protein response	14
Participation of preovulatory follicles in the activation of primordial follicles in mouse ovaries	14
Exosomes: The emerging mechanisms and potential clinical applications in dermatology	14
Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing	14
Upregulation of LRRC8A by m⁵C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer	14
Small Intestine-specific Knockout of CIDEC Improves Obesity and Hepatic Steatosis by Inhibiting Synthesis of Phosphatidic Acid	14