OOIR: Observatory of International Research

Papers

(The H4-Index of International Journal of Biological Sciences is 67. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer	300
A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer	262
COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2	260
Outer Membrane Vesicles Derived from Oral Bacteria Act as a Dagger in Host Immunity: Insight Tips from Local Diseases to Systemic Effects	239
Stem cells enhance their chondrogenic differentiation in hydrogels by mechanical tumbling	232
Therapeutic Activation of PPARα Inhibits Transformed Follicular Lymphoma Tumorigenesis via the FOXM1 Signaling Pathway	220
SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway	213
Dysregulated Ribosome Biogenesis Is a Targetable Vulnerability in Triple-Negative Breast Cancer: MRPS27 as a Key Mediator of the Stemness-inhibitory Effect of Lovastatin	187
Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys	186
ETV4 interacts with LOXL2 to induce epigenetic activation of NID1 during colorectal cancer progression	183
Mechanistic role of metal-responsive transcription factor-1 (MTF-1) in cadmium-induced prostate carcinogenesis	161
Comprehensive Histopathology Imaging in Pancreatic Biopsies: High Definition Infrared Imaging with Machine Learning Approach	160
Extracellular vesicles, the emerging mirrors of brain physiopathology	154
MKL-1 suppresses ferroptosis by activating system Xc- and increasing glutathione synthesis	144
Crosstalk between arachidonic acid metabolism and glycolysis drives integrated metabolic-inflammatory reprogramming in macrophages	143
Piezo1-driven mechanotransduction regulates mitochondrial biogenesis by AMPK/SIRT1-mediated PGC-1α deacetylation to ameliorate bone loss in disuse osteoporosis	142
Targeting the HSP60/p53 Axis with Extracellular Vesicle-Delivered siRNA Reprograms Glycolysis in Prostate Cancer	140
Gut Microbiota-Driven Pathways Linking Chronic Stress to Tumor Progression	134
Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice	130
SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer	129
The dysadherin/FAK axis promotes individual cell migration in colon cancer	128
TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver disease via nitric oxide production	126
Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers	125
PPDPF Promotes the Progression and acts as an Antiapoptotic Protein in Non-Small Cell Lung Cancer	124
Pathogenesis and treatment strategies of sepsis-induced myocardial injury: modern and traditional medical perspectives	116

Antioxidant genes in cancer and metabolic diseases: Focusing on Nrf2, Sestrin, and heme oxygenase 1	116
Reconstruction of the Hepatic Microenvironment and Pathological Changes Underlying Type II Diabetes through Single-Cell RNA Sequencing	116
Macrophages in Focus: Key Drivers and Therapeutic Opportunities in Diabetic Kidney Disease	114
The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis In Vitro and In Vivo	108
Nlp-dependent ER-to-Golgi transport	104
Digging out MDIG from the mess of H3K9me3, OTX2 and MYC signaling in human cancers	103
Inhibition of the HMGB1/RAGE axis protects against cisplatin-induced ototoxicity via suppression of inflammation and oxidative stress	101
RNA-binding motif protein 10 represses tumor progression through the Wnt/β- catenin pathway in lung adenocarcinoma	99
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells	95
Loss of DDRGK1 impairs IRE1α UFMylation in spondyloepiphyseal dysplasia	94
Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma	91
Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma	90
Exosomes: a promising microenvironment modulator for spinal cord injury treatment	85
Cancer-associated fibroblasts promote migration and invasion of non-small cell lung cancer cells via METTL3-mediated RAC3 m⁶A modification	83
Regulation of lung epithelial cell senescence in smoking-induced COPD/emphysema by microR-125a-5p via Sp1 mediation of SIRT1/HIF-1a	83
P2RY13 Exacerbates Intestinal Inflammation by Damaging the Intestinal Mucosal Barrier via Activating IL-6/STAT3 Pathway	82
As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma	81
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases	80
CD151 promotes Colorectal Cancer progression by a crosstalk involving CEACAM6, LGR5 and Wnt signaling via TGFβ1: Erratum	78
The Novel Role of hnRNP UL1 in Human Cell Nucleoli	77
Altered Heme and Redox Homeostasis Underpin Late-onset Alzheimer's Disease	76
IL-38 Aggravates Atopic Dermatitis via Facilitating Migration of Langerhans cells	76
PSMC6 regulation of ovarian cancer cisplatin resistance unravels a new mode for proteasome targeting	76
Dual-specificity tyrosine-regulated kinase 4 modulates the STAT3-FOS signaling axis to inhibit hepatitis B virus replication via autophagy	76
PTPN22 Dephosphorylates CBL to Inhibit PD-L1 Ubiquitination and Drive Immunosuppression in Renal Cell Carcinoma	74
Polysaccharide isolated from Grifola frondosa eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T cells responses	73
TBX21 inhibits colorectal cancer metastasis through ARHGAP29/GSK3β inhibitory signaling- and MYCT1/ZO-1 signaling-dependent manner	73
NUF2 Drives Cholangiocarcinoma Progression and Migration via Inhibiting Autophagic Degradation of TFR1	73
Methyltransferase Set7/9 as a Multifaceted Regulator of ROS Response	72
Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1	72
Neurotrophin3 promotes hepatocellular carcinoma apoptosis through the JNK and P38 MAPK pathways	71
Targeting Necroptosis: A Novel Therapeutic Option for Retinal Degenerative Diseases	71
Glycine Decarboxylase Regulates Renal Carcinoma Progression via Interferon Stimulated Gene Factor 3-Mediated Pathway	71
Identification of Gαi3 as a promising target for osteosarcoma treatment	71
Traditional Chinese Medicine JingYinGuBiao Formula Therapy Improves the Negative Conversion Rate of SARS-CoV2 in Patients with Mild COVID-19	71
Treatment for type 2 diabetes and diabetic nephropathy by targeting Smad3 signaling	70
TRIM37 Augments AP-2γ Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression	69
tRF-27 competitively Binds to G3BPs and Activates MTORC1 to Enhance HER2 Positive Breast Cancer Trastuzumab Tolerance	69
RNA methylation-mediated LINC01559 suppresses colorectal cancer progression by regulating the miR-106b-5p/PTEN axis	68
N-Acetylcysteine Alleviates Depressive-Like Behaviors in Adolescent EAAC1^-/- Mice and Early Life Stress Model Rats	68
The role of RGC degeneration in the pathogenesis of glaucoma	67
Oxidative stress promotes liver fibrosis by modulating the microRNA-144 and SIN3A-p38 pathways in hepatic stellate cells	67
Paris saponin VII reverses resistance to PARP inhibitors by regulating ovarian cancer tumor angiogenesis and glycolysis through the RORα/ECM1/VEGFR2 signaling axis	67