OOIR: Observatory of International Research

Papers

(The H4-Index of International Journal of Biological Sciences is 60. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer	350
Stem cells enhance their chondrogenic differentiation in hydrogels by mechanical tumbling	256
The dysadherin/FAK axis promotes individual cell migration in colon cancer	240
MKL-1 suppresses ferroptosis by activating system Xc- and increasing glutathione synthesis	232
Crosstalk between arachidonic acid metabolism and glycolysis drives integrated metabolic-inflammatory reprogramming in macrophages	220
Mechanistic role of metal-responsive transcription factor-1 (MTF-1) in cadmium-induced prostate carcinogenesis	178
Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers	171
Targeting the HSP60/p53 Axis with Extracellular Vesicle-Delivered siRNA Reprograms Glycolysis in Prostate Cancer	171
GIPC1 Restrains the Progression and Chemoresistance of Colorectal Cancer by Regulating TTC7B/mTOR/NF-κB Axis	163
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells	148
p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer	145
Digging out MDIG from the mess of H3K9me3, OTX2 and MYC signaling in human cancers	140
A crosstalk between tumor cells and adipocytes facilitates tumor cell migration and invasion	138
SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer	132
Reconstruction of the Hepatic Microenvironment and Pathological Changes Underlying Type II Diabetes through Single-Cell RNA Sequencing	124
Targeting Lysosomes for Enhanced Anti-Cancer Therapeutics and Immune Response	121
Nlp-dependent ER-to-Golgi transport	120
Inhibition of the HMGB1/RAGE axis protects against cisplatin-induced ototoxicity via suppression of inflammation and oxidative stress	117
The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis In Vitro and In Vivo	111
Therapeutic Activation of PPARα Inhibits Transformed Follicular Lymphoma Tumorigenesis via the FOXM1 Signaling Pathway	110
ALYREF-mediated m ⁵ C modification of CCNA1 drives escape from cell-cycle arrest and contributes to pazopanib resistance in Renal Cell Carcinoma	108
Outer Membrane Vesicles Derived from Oral Bacteria Act as a Dagger in Host Immunity: Insight Tips from Local Diseases to Systemic Effects	107
Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys	95
ETV4 interacts with LOXL2 to induce epigenetic activation of NID1 during colorectal cancer progression	94
Cancer-associated fibroblasts promote migration and invasion of non-small cell lung cancer cells via METTL3-mediated RAC3 m⁶A modification	93

TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver disease via nitric oxide production	91
Loss of DDRGK1 impairs IRE1α UFMylation in spondyloepiphyseal dysplasia	84
Macrophages in Focus: Key Drivers and Therapeutic Opportunities in Diabetic Kidney Disease	83
Extracellular vesicles, the emerging mirrors of brain physiopathology	81
Nuclear Mechanotransduction at the Crossroads: How Membrane Receptors Remodel the Perinuclear Cytoskeleton to Drive Cancer and Disease	80
HLA class I-specific nucleolin peptides induce therapeutic T cells in triple-negative breast cancer patients	80
Gut Microbiota-Driven Pathways Linking Chronic Stress to Tumor Progression	80
Pathogenesis and treatment strategies of sepsis-induced myocardial injury: modern and traditional medical perspectives	79
Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma	75
Dysregulated Ribosome Biogenesis Is a Targetable Vulnerability in Triple-Negative Breast Cancer: MRPS27 as a Key Mediator of the Stemness-inhibitory Effect of Lovastatin	75
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases	74
Excessive Kynurenine Metabolism Impairs Lysosomal acidification and Triggers mtDNA Release via the AHR/CISH/ATP6V1A Axis in Decidual Macrophages Associated with Unexplained Recurrent Pregnancy Loss	73
Comprehensive Histopathology Imaging in Pancreatic Biopsies: High Definition Infrared Imaging with Machine Learning Approach	73
Antioxidant genes in cancer and metabolic diseases: Focusing on Nrf2, Sestrin, and heme oxygenase 1	73
Piezo1-driven mechanotransduction regulates mitochondrial biogenesis by AMPK/SIRT1-mediated PGC-1α deacetylation to ameliorate bone loss in disuse osteoporosis	72
SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway	71
CD151 promotes Colorectal Cancer progression by a crosstalk involving CEACAM6, LGR5 and Wnt signaling via TGFβ1: Erratum	70
Exosomes: a promising microenvironment modulator for spinal cord injury treatment	70
Altered Heme and Redox Homeostasis Underpin Late-onset Alzheimer's Disease	69
TBX21 inhibits colorectal cancer metastasis through ARHGAP29/GSK3β inhibitory signaling- and MYCT1/ZO-1 signaling-dependent manner	68
IL-38 Aggravates Atopic Dermatitis via Facilitating Migration of Langerhans cells	67
NUF2 Drives Cholangiocarcinoma Progression and Migration via Inhibiting Autophagic Degradation of TFR1	67
Orphan Nuclear Receptor NR4A1 Promotes Proliferation and Osteogenic Differentiation of Valvular Interstitial Cells through Activation of CCND2	67
NLRX1 Drives Prostate Cancer Progression Through Activation of AKT and ERK Signaling Pathways	66
PROX1-mediated epigenetic silencing of SIRT3 contributes to proliferation and glucose metabolism in colorectal cancer	66
Novel glycoprotein SBSPON suppressed bladder cancer through the AKT signal pathway by inhibiting HSPA5 membrane translocation	66
Fangchinoline Activates cGAS-STING to Promote Antitumor Immunity without Pathological Inflammation	64
Impaired redox adaptation through SLC38A5-dependent glutamine metabolism contributes to melatonin-mediated anoikis sensitivity and metastasis suppression in bone cancer	63
Activation of central Angiotensin-(1-7)/Mas receptor alleviates synaptic damage in diabetes-associated cognitive impairment via modulating AKT/FOXO1/PACAP axis	63
Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress	63
Glycine Decarboxylase Regulates Renal Carcinoma Progression via Interferon Stimulated Gene Factor 3-Mediated Pathway	62
Ugonin P mitigates osteolytic bone metastasis by suppressing MDK via upregulating miR-223-3p expression	61
TM4SF5-mediated KEAP1 Regulation in Hepatocytes Irrelevant to NRF2 Expression and Activity Promotes Oxidative Stress and Inflammation to Develop Metabolic Dysfunction-Associated Steatotic Liver Diseas	61
Paris saponin VII reverses resistance to PARP inhibitors by regulating ovarian cancer tumor angiogenesis and glycolysis through the RORα/ECM1/VEGFR2 signaling axis	60
Macrophage-Orchestrated Metabolic Sensing Drives IBD Pathogenesis: A Framework for Targeted Therapy	60