OOIR: Observatory of International Research

Papers

(The median citation count of Reproductive Medicine and Biology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Risk factors for empty follicle syndrome in assisted reproductive technology with gonadotropin‐releasing hormone agonist trigger	51
Ectopic expression of the mitochondrial protein COXFA4L3 in human sperm acrosome and its potential application in the selection of male infertility treatments	47
Tacrolimus treatment in women with repeated implantation failures	32
Mechanobiology of the female reproductive system	30
Saturated fatty acids accelerate linear motility through mitochondrial ATP production in bull sperm	26
Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues	24
CDX2 downregulation in mouse mural trophectoderm during peri‐implantation is heteronomous, dependent on the YAP‐TEAD pathway and controlled by estrogen‐induced factors	24
Accumulation of fibrosis and altered perifollicular stromal differentiation in vitrified‐thawed human ovarian tissue xenografted to nude mice.	23
Pathophysiology of polycystic ovary syndrome revisited: Current understanding and perspectives regarding future research	23
Aspiration of excess follicles before intrauterine insemination in high response cycles	23
Donor insemination for heterosexual couples: A practice in transition	22
TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility	22
Reviewer Acknowledgment	21
Prevalence, definition, and etiology of cesarean scar defect and treatment of cesarean scar disorder: A narrative review	21
Exome‐based genome‐wide screening of rare variants associated with the risk of polycystic ovary syndrome	20
	19
The morphokinetics algorithm based on data from day 5 blastocyst transfer (KIDScoreD5 version 3) is also useful for embryo selection in day 6 blastocyst transfer	19
Current status of genome‐wide epigenetic profiling of mammalian preimplantation embryos	19
Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer	18
Anthropometric measurements of term singletons at 6 years of age born from fresh and frozen embryo transfer: A multicenter prospective study in Japan	18
Cryptozoospermia: Should we use ejaculated sperm or surgically retrieved sperm for assisted reproductive technology?	17
Efficacy and safety of follitropin delta versus follitropin alpha/beta in infertility treatment: A systematic review and meta‐analysis	16
Homozygous FIGLA missense variant in two Japanese sisters with primary ovarian insufficiency: Case reports and literature review	16
	16
The novel oral gonadotropin‐releasing hormone receptor antagonist relugolix is a new option for controlled ovarian stimulation cycles	16

The possible effects of the Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 on the practice of fertility preservation in female cancer patients in Japan	16
Evaluation of the efficacy of creatine chemical exchange saturation transfer imaging in assessing testicular maturity	16
Distribution of the follicular and luteal phase lengths and their age‐dependent changes in Japanese women: A large population study	15
Impact of abnormal karyotype on reproductive outcome in premature ovarian insufficiency	15
Time from trophectoderm biopsy to vitrification affects the developmental competence of biopsied blastocysts	15
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Shallow artificial networks with morphokinetic time‐lapse parameters coupled to ART data allow to predict live birth	14
Optimizing treatment efficacy and fertility preservation in patients undergoing hematopoietic stem cell transplantation: A narrative review of ovarian shielding with total‐body irradiation or treosulf	14
Molecular mechanism of autophagy and apoptosis in endometriosis: Current understanding and future research directions	14
Cumulative live birth rate according to the number of receiving governmental subsidies for assisted reproductive technology in Saitama Prefecture, Japan: A retrospective study using individual data fo	13
Issue Information	13
IVM of human immature oocytes for infertility treatment and fertility preservation	12
Impact of heparin‐aspirin therapy in patients with recurrent pregnancy loss characterized by thrombophilia resistant to low‐dose aspirin therapy: A retrospective study	12
Therapeutic efficacy of the optimization of thyroid function, thrombophilia, immunity and uterine milieu (OPTIMUM) treatment strategy on pregnancy outcomes after single euploid blastocyst t	11
Progesterone resistance in endometriosis: A pathophysiological perspective and potential treatment alternatives	11
High incidence of decidualization failure in infertile women	11
The effectiveness of controlled ovarian stimulation with tamoxifen for patients with estrogen‐sensitive breast cancer: A systematic review and meta‐analysis	11
Therapeutic efficacy of gentle endometrial curettage on antibiotic‐resistant chronic endometritis in infertile women	10
Effect of hypothyroidism and thyroid autoimmunity on the ovarian reserve: A systematic review and meta‐analysis	10
A novel system based on artificial intelligence for predicting blastocyst viability and visualizing the explanation	10
	10
Sperm DNA fragmentation testing in clinical management of reproductive medicine	10
Usefulness of expanding the indications of early rescue intracytoplasmic sperm injection	10
Ovarian tissue grafting: Lessons learnt from our experience with 55 grafts	9
Effect of post‐warming culture time on the live birth rate after frozen embryo transfer	9
NR5A1 and cell population heterogeneity: Insights into developmental and functional disparities and regulatory mechanisms	9
Impact of current and previous sperm findings on outcomes of intrauterine insemination	9
Embryos, cancers, and parasites: Potential applications to the study of reproductive biology in view of their similarity as biological phenomena	9
Aneuploidy and sex concordance rate between cell‐free DNA analysis from spent culture media of preimplantation embryo and DNA from whole embryo with respect to different morpholo	9
Clinical relevance of a newly developed endometrial receptivity test for patients with recurrent implantation failure in Japan	8
Expression and co‐localization of RFRP‐3 and kisspeptin during breeding and non‐breeding season in the hypothalamus of male rhesus monkey (Macaca mulatta)	8
Gamma‐aminobutyric acid (GABA) can affect physiological processes in preimplantation embryos via GABA_A and GABA_B receptors	8
Roles of lipid mediators in early pregnancy events	8
Occurrence of chronic endometritis in different types of human adenomyosis	8
The impact of oocyte death on mouse primordial follicle formation and ovarian reserve	8
Issue Information	8
Prevalence of functional hypothalamic amenorrhea in a cohort of women referred because of polycystic ovary syndrome	7
A gene network of uterine luminal epithelium organizes mouse blastocyst implantation	7
Assisted reproductive technology in Japan: A summary report for 2020 by the ethics Committee of the Japan Society of obstetrics and gynecology	7
Age‐dependent phenotypes of ovarian endometriomas	7
An assessment of the efficacy and safety of dydrogesterone in women with ovarian endometrioma: An open‐label multicenter clinical study	7
Assisted reproductive technology in Japan: A summary report for 2021 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology	7
Effects of Hochuekkito, a traditional Japanese medicine (Kampo), on reproduction of aging female mice	7
Effects of paternal ionizing radiation exposure on fertility and offspring's health	7
Expression of RSPH6A in the first wave of rat spermatogenesis and oxidative stress conditions: Attenuation by melatonin	6
microRNAs associated with the quality of follicular fluids affect oocyte and early embryonic development	6
Reproductive outcomes of embryo cryopreservation and transfer at the start‐up phase of fertility preservation in Japan	6
Compound heterozygous KCTD19 variants in a man with isolated nonobstructive azoospermia	6
Sirolimus‐ and cyclosporine‐loaded nanostructured lipid carriers: Development, characterization, and in vitro evaluation in T‐cell profiles of patients with a history of recurrent pregnancy loss	6
Assisted reproductive technology in Japan: A summary report for 2019 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology	6

Differences in clinical outcomes between men with mosaic Klinefelter syndrome and those with non‐mosaic Klinefelter syndrome	6
A controlled clinical trial comparing potent progestins, LNG‐IUS and dienogest, for the treatment of women with adenomyosis	6
Improved developmental potential of mouse vitrified‐warmed oocytes achieved by culturing in recovery medium with glutathione ethyl ester (GSH‐OEt)	6
Chromosome segregation errors during early embryonic development	6
The physiological role of macrophages in reproductive organs	6
The Asian Society of Endometriosis and Adenomyosis guidelines for managing adenomyosis	6
Clinicopathological characteristics and imaging findings to identify adenomyosis‐related symptoms	6
Toll‐like receptors in mammalian sperm	6
Therapeutic effects of an oral gonadotropin‐releasing hormone receptor antagonist, relugolix, on preventing premature ovulation in mild ovarian stimulation for IVF	5
Japanese reproductive medicine under health insurance: A brief review and prospects	5
Very severe oligozoospermia with AZFc microdeletion patients may affect intracytoplasmic sperm injection clinical outcomes: A propensity score matching analysis	5
Role of varicocele repair in the era of assisted reproductive technologies: Lessons from 2000 cases of microsurgical varicocele repair	5
Swim‐up method is superior to density gradient centrifugation for preserving sperm DNA integrity during sperm processing	5
Mosaic loss of the Y chromosome and men's health	5
Establishment of mouse line showing inducible priapism‐like phenotypes	5
The impact of dietary interventions on polycystic ovary syndrome patients with a BMI ≥25 kg/m²: A systematic review and meta‐analysis of randomized controlled trials	5
How does the extent of fibrosis in adenomyosis lesions contribute to heavy menstrual bleeding?	5
A novel orally active gonadotropin‐releasing hormone antagonist, relugolix, is a potential substitute for injectable GnRH antagonists in controlled ovarian stimulation in assisted reproductive technol	5
Reinfusion of peritoneal fluid elevates the level of plasma D‐dimer in patients with early‐onset ovarian hyperstimulation syndrome	5
Spermatozoa from male mice with infertility due to Odf4 deficiency can fertilize oocytes by in vitro fertilization	4
Influence of a patient education and care program on women undergoing non‐assisted reproductive technology fertility treatment	4
Influence of lifestyle and the circadian clock on reproduction	4
Sperm immobilization test and quantitative sperm immobilization test using frozen‐thawed sperm preparation applied with computer‐aided sperm analysis	4
Risk factors for non‐previa placenta accreta spectrum in pregnancies conceived through frozen embryo transfer during a hormone replacement cycle in Japan	4
Mitochondrial function of human embryo: Decline in their quality with maternal aging	4
Polycystic ovary syndrome: Criteria, phenotypes, race and ethnicity	4
Potential for artificial intelligence in medicine and its application to male infertility	4
Expression of NKp46 and other activating inhibitory receptors on uterine endometrial NK cells in females with various reproductive failures: A review	4
IGF‐I and NGFβ enhance in vitro progressive motility and vitality of human spermatozoa	4
The addition of dydrogesterone improves the outcomes of pregnant women with low progesterone levels when receiving vaginal progesterone alone as luteal support in HRT‐FET cycles	4
Combined histological and DNA methylome profiling approaches may provide insights into the pathophysiology of ovarian endometriomas	4
The effects of differences in trophectoderm biopsy techniques and the number of cells collected for biopsy on next‐generation sequencing results	4
Follicle development and its prediction in patients with primary ovarian insufficiency: Possible treatments and markers to maximize the ability to conceive with residual follicles	4
Paracrine regulation of granulosa cell development in the antral follicles in mammals	3
Consistency between chromosomal status analysis of biopsied human blastocyst trophectoderm cells and whole blastocyst cells	3
Similarities and differences in placental development between humans and cynomolgus monkeys	3
A novel trophectoderm biopsy technique for all blastocyst stages	3
Genetic variants of G‐protein coupled receptors associated with pubertal disorders	3
Novel approaches to the management of recurrent pregnancy loss: The OPTIMUM (OPtimization of Thyroid function, Thrombophilia, Immunity, and Uterine Milieu) treatment strategy	3
Molecular basis of the morphogenesis of sperm head and tail in mice	3
Hormonal support in women with Asherman syndrome does not lead to better outcomes: A randomized trial	3
Loss of Axdnd1 causes sterility due to impaired spermatid differentiation in mice	3
KEAP1–NRF2 system regulates age‐related spermatogenesis dysfunction	3
Overview of single‐cell RNA sequencing analysis and its application to spermatogenesis research	3
Guidelines for Reproductive Medicine in Japan	3
Developmental perturbation in human embryos: Clinical and biological significance learned from time‐lapse images	3
Usefulness of combined NGS and QF‐PCR analysis for product of conception karyotyping	3
The effect of ionizing radiation on testicular interstitial stromal cells	3
Revisiting non‐obstructive azoospermia: Is there a best way to retrieve testicular sperm?	3
Melatonin improves the in vitro growth of bovine oocytes collected from early antral follicles by maintaining oocyte‐cumulus cell communication	3
Lipid droplet biogenesis in the ovary	3
Neurological development in 36‐month‐old children conceived via assisted reproductive technology: The Japan Environment and Children's Study	3
Issue Information	3
Preimplantation genetic testing might not be the necessity for male patients with 47,XYY syndrome: A pilot study	3
Sod1 deficiency in mouse oocytes during in vitro maturation increases chromosome segregation errors with a reduced BUBR1 at kinetochore	3
The migration speed of nucleolar precursor bodies in pronuclei affects in vitro fertilization‐derived human embryo ploidy status and live birth	3
Three‐dimensional reconstruction of testis cords/seminiferous tubules	3
Association between anti‐Müllerian hormone levels and polycystic ovary syndrome in a general cohort of young women in Japan	3
A new deep‐learning model using YOLOv3 to support sperm selection during intracytoplasmic sperm injection procedure	3
Embryologist staffing in assisted reproductive technology laboratories: An international comparative review	3
The ratio of 2nd to 4th digit length and reproductive function of infertile male patients	2
Therapeutic efficacy and safety of a free‐standing motorized ejaculation aid for patients with intravaginal ejaculatory dysfunction	2
Fertilization, embryo culture, and clinical results using low lactate embryo culture medium for pre‐culture, insemination, and beyond	2
Kisspeptin neurons as an integration center of reproductive regulation: Observation of reproductive function based on a new concept of reproductive regulatory nervous system	2
A new clustering model based on the seminal plasma/serum ratios of multiple trace element concentrations in male patients with subfertility	2
Establishment of a 3D spheroid culture system to evaluate the responsiveness of uterine leiomyoma cells to female hormones	2
Analysis of clinical outcomes and meiotic segregation modes following preimplantation genetic testing for structural rearrangements using aCGH/NGS in couples with balanced chromo	2
Neurotensin induces sustainable activation of the ErbB–ERK1/2 pathway, which is required for developmental competence of oocytes in mice	2
	2
Novel erectile analyses revealed augmentable penile Lyve‐1, the lymphatic marker, expression	2
Serum copper to zinc ratio and risk of endometriosis: Insights from a case–control study in infertile patients	2
Effect of docosahexaenoic acid on in vitro growth of bovine oocytes	2
Predicting implantation by using dual AI system incorporating three‐dimensional blastocyst image and conventional embryo evaluation parameters—A pilot study	2
Small GTP‐binding protein Rap1 mediates EGF and HB‐EGF signaling and modulates EGF receptor expression in HTR‐8/SVneo extravillous trophoblast cells	2
Adverse effect of lactobacilli‐depauperate cervicovaginal microbiota on pregnancy outcomes in women undergoing frozen–thawed embryo transfer	2
A review of the optimization of thyroid function, thrombophilia, immunity and uterine milieu: OPTIMUM treatment strategy for recurrent implantation failure and recurrent pregnancy loss	2
C‐type natriuretic peptide promotes human granulosa cell growth and estradiol production: Implications for early follicle development	2
Increased risk of obstetric complications in patients with adenomyosis: A narrative literature review	2
High concentration of dopamine treatment may induce acceleration of human sperm motility	2
Risks of neonatal anomalies and obstetric complications in 7378 singleton births after frozen–thawed and fresh embryo transfers in Japan: An analysis using doubly robust estimation	2