OOIR: Observatory of International Research

Papers

(The median citation count of Reproductive Medicine and Biology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Clinicopathological characteristics and imaging findings to identify adenomyosis‐related symptoms	62
Improvement of oocyte quality through the SIRT signaling pathway	36
Molecular and cellular regulators of embryo implantation and their application in improving the implantation potential of IVF‐derived blastocysts	28
Sod1 deficiency in mouse oocytes during in vitro maturation increases chromosome segregation errors with a reduced BUBR1 at kinetochore	24
Therapeutic effects of an oral gonadotropin‐releasing hormone receptor antagonist, relugolix, on preventing premature ovulation in mild ovarian stimulation for IVF	22
Upregulated serum granulysin levels in women with antiphospholipid antibody‐associated recurrent miscarriage are downregulated by heparin treatment	20
Risk factors for empty follicle syndrome in assisted reproductive technology with gonadotropin‐releasing hormone agonist trigger	20
DNA damage in human sperm: The sperm chromosome assay	20
Genomic imprinting in human placentation	19
Decrease in serum anti‐Müllerian hormone level per puncture with laparoscopic ovarian drilling using ultrasonically activated device	18
Differential expression of estrogen receptor subtypes in ovarian high‐grade serous carcinoma and clear cell carcinoma	16
Isolation and characterization of fetal nucleated red blood cells from maternal blood as a target for single cell sequencing‐based non‐invasive genetic testing	16
A novel trophectoderm biopsy technique for all blastocyst stages	16
Sphingosine kinases negatively regulate the expression of matrix metalloproteases (MMP1 and MMP3) and their inhibitor TIMP3 genes via sphingosine 1‐phosphate in extravillous troph	16
Usefulness of expanding the indications of early rescue intracytoplasmic sperm injection	16
TSNAXIP1 is required for sperm head formation and male fertility	15
Effect of early rescue ICSI and split IVF‐ICSI in preventing low fertilization rate during the first ART cycle: A real‐world retrospective cohort study	14
Therapeutic efficacy of gentle endometrial curettage on antibiotic‐resistant chronic endometritis in infertile women	14
Serum leucine‐rich α2‐glycoprotein as a possible marker for inflammatory status in endometriosis	14
Assisted reproductive technique outcomes in patients with endometrioma undergoing sclerotherapy vs laparoscopic cystectomy: Prospective cross‐sectional study	14
Establishment of mouse line showing inducible priapism‐like phenotypes	13
Genetic variants of G‐protein coupled receptors associated with pubertal disorders	13
Effect of transdermal estrogen dose regimen for endometrial preparation of frozen‐thawed embryo transfer on reproductive and obstetric outcomes	12
Mechanobiology of the female reproductive system	11
How to improve the clinical outcome of round spermatid injection (ROSI) into the oocyte: Correction of epigenetic abnormalities	11

3D reconstruction and histopathological analyses on murine corporal body	11
CDX2 downregulation in mouse mural trophectoderm during peri‐implantation is heteronomous, dependent on the YAP‐TEAD pathway and controlled by estrogen‐induced factors	11
Saturated fatty acids accelerate linear motility through mitochondrial ATP production in bull sperm	11
The prevalence of celiac disease in women with infertility—A systematic review with meta‐analysis	10
Effect of single versus grouped culture of human cumulus–oocyte complexes in PCOS women treated with biphasic in vitro maturation: A sibling oocyte pilot study	10
Pathophysiology of polycystic ovary syndrome revisited: Current understanding and perspectives regarding future research	10
Effect of hypothyroidism and thyroid autoimmunity on the ovarian reserve: A systematic review and meta‐analysis	10
How does the extent of fibrosis in adenomyosis lesions contribute to heavy menstrual bleeding?	10
Role of varicocele repair in the era of assisted reproductive technologies: Lessons from 2000 cases of microsurgical varicocele repair	10
Tacrolimus treatment in women with repeated implantation failures	9
Swim‐up method is superior to density gradient centrifugation for preserving sperm DNA integrity during sperm processing	9
Correction to “A new clustering model based on the seminal plasma/serum ratios of multiple trace element concentrations in male patients with subfertility”	9
Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues	9
The impact of dietary interventions on polycystic ovary syndrome patients with a BMI ≥25 kg/m²: A systematic review and meta‐analysis of randomized controlled trials	9
Very severe oligozoospermia with AZFc microdeletion patients may affect intracytoplasmic sperm injection clinical outcomes: A propensity score matching analysis	9
Ectopic expression of the mitochondrial protein COXFA4L3 in human sperm acrosome and its potential application in the selection of male infertility treatments	9
Exploring edible bird nest's potential in mitigating Wi‐Fi's impact on male reproductive health	9
Developmental perturbation in human embryos: Clinical and biological significance learned from time‐lapse images	9
Ovarian tissue grafting: Lessons learnt from our experience with 55 grafts	8
A controlled clinical trial comparing potent progestins, LNG‐IUS and dienogest, for the treatment of women with adenomyosis	8
Reorganization, specialization, and degradation of oocyte maternal components for early development	8
Guidelines for Reproductive Medicine in Japan	8
Reinfusion of peritoneal fluid elevates the level of plasma D‐dimer in patients with early‐onset ovarian hyperstimulation syndrome	8
Mosaic loss of the Y chromosome and men's health	8
Similarities and differences in placental development between humans and cynomolgus monkeys	8
Reproductive medical providers’ behaviors, considerations, and plans for fertility treatments during the COVID‐19 pandemic in Japan: A nationwide web‐based survey	7
Pre‐culture with transferrin‐Fe³⁺ before in vitro maturation improves the developmental competence of porcine oocytes matured in vitro	7
Aspiration of excess follicles before intrauterine insemination in high response cycles	7
Exome‐based genome‐wide screening of rare variants associated with the risk of polycystic ovary syndrome	7
Issue Information	7
Shapes of the uterine cavity are different in women with polycystic ovary syndrome	7
Mitochondrial function of human embryo: Decline in their quality with maternal aging	7
IGF‐I and NGFβ enhance in vitro progressive motility and vitality of human spermatozoa	7
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Role of immune cells in the establishment of implantation and maintenance of pregnancy and immunomodulatory therapies for patients with repeated implantation failure and recurrent pregnancy loss	6
Chlormadinone acetate in progestin‐primed ovarian stimulation does not negatively affect clinical results	6
Efficacy of cyclic and extended regimens of ethinylestradiol 0.02 mg ‐levonorgestrel 0.09 mg for dysmenorrhea: A placebo‐controlled, double‐blind, randomized trial	6
Adverse effect of lactobacilli‐depauperate cervicovaginal microbiota on pregnancy outcomes in women undergoing frozen–thawed embryo transfer	5
Donor insemination for heterosexual couples: A practice in transition	5
Small GTP‐binding protein Rap1 mediates EGF and HB‐EGF signaling and modulates EGF receptor expression in HTR‐8/SVneo extravillous trophoblast cells	5
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Issue Information	5
Effect of post‐warming culture time on the live birth rate after frozen embryo transfer	5
Therapeutic efficacy and safety of a free‐standing motorized ejaculation aid for patients with intravaginal ejaculatory dysfunction	5
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Relation between semen oxidative reduction potential in initial semen examination and IVF outcomes	5
Fertilization, embryo culture, and clinical results using low lactate embryo culture medium for pre‐culture, insemination, and beyond	5
Consistency between chromosomal status analysis of biopsied human blastocyst trophectoderm cells and whole blastocyst cells	5
Accumulation of fibrosis and altered perifollicular stromal differentiation in vitrified‐thawed human ovarian tissue xenografted to nude mice.	5
Effects of aging and oviductal hormones on testes, epididymides, and sperm of hamster	4

Impact of current and previous sperm findings on outcomes of intrauterine insemination	4
Development of an AI‐based support system for controlled ovarian stimulation	4
Spermatozoa from male mice with infertility due to Odf4 deficiency can fertilize oocytes by in vitro fertilization	4
The expression of human testis‐specific actin capping protein predicts in vitro fertilization outcomes: A novel biomarker of sperm function for assisted reproductive technology	4
A novel orally active gonadotropin‐releasing hormone antagonist, relugolix, is a potential substitute for injectable GnRH antagonists in controlled ovarian stimulation in assisted reproductive technol	4
Influence of sperm cryopreservation on sperm motility and proAKAP4 concentration in mice	4
Verification of the utility of the gonadotropin starting dose calculator in progestin‐primed ovarian stimulation: A comparison of empirical and calculated controlled ovarian stimulation	4
Oxidative stress affects sperm health and fertility—Time to apply facts learned at the bench to help the patient: Lessons for busy clinicians	4
Molecular crosstalk between insulin‐like growth factors and follicle‐stimulating hormone in the regulation of granulosa cell function	4
Endometrial polyps with increased plasma cells are associated with chronic endometritis in infertility patients: Hysteroscopic findings and post‐polypectomy pregnancy rates	4
TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility	4
Age‐ and endometrial microbiota‐related delay in development of endometrial receptivity	4
Neurotensin induces sustainable activation of the ErbB–ERK1/2 pathway, which is required for developmental competence of oocytes in mice	4
Reviewer Acknowledgment	4
Prominin‐1 expression in the testis/epididymis and fertility	4
Aberrant expression of histone deacetylase 8 in endometriosis and its potential as a therapeutic target	4
The addition of dydrogesterone improves the outcomes of pregnant women with low progesterone levels when receiving vaginal progesterone alone as luteal support in HRT‐FET cycles	3
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Prevalence, definition, and etiology of cesarean scar defect and treatment of cesarean scar disorder: A narrative review	3
Aneuploidy and sex concordance rate between cell‐free DNA analysis from spent culture media of preimplantation embryo and DNA from whole embryo with respect to different morpholo	3
Follicle development and its prediction in patients with primary ovarian insufficiency: Possible treatments and markers to maximize the ability to conceive with residual follicles	3
Clinical outcomes of personalized blastocyst embryo transfer after endometrial receptivity analysis: A multicenter, retrospective cohort study	3
Clinical relevance of a newly developed endometrial receptivity test for patients with recurrent implantation failure in Japan	3
The impact of oocyte death on mouse primordial follicle formation and ovarian reserve	3
The impact of the embryo banking on the cumulative live birth rate in women with poor ovarian response according to the Bologna criteria	3
Effects of antioxidant co‐supplementation therapy on spermatogenesis dysfunction in relation to the basal oxidation–reduction potential levels in spermatozoa: A pilot study	3
Analysis of clinical outcomes and meiotic segregation modes following preimplantation genetic testing for structural rearrangements using aCGH/NGS in couples with balanced chromo	3
Preimplantation genetic testing for aneuploidy and chromosomal structural rearrangement: A summary of a nationwide study by the Japan Society of Obstetrics and Gynecology	3
The ratio of 2nd to 4th digit length and reproductive function of infertile male patients	3
C‐type natriuretic peptide promotes human granulosa cell growth and estradiol production: Implications for early follicle development	3
Combined histological and DNA methylome profiling approaches may provide insights into the pathophysiology of ovarian endometriomas	3
Indication of intravaginal insemination for infertility treatment in couples with sexual dysfunction	3
Cryptozoospermia: Should we use ejaculated sperm or surgically retrieved sperm for assisted reproductive technology?	3
Status of online sperm donation and sperm bank in Japan	3
Chances of pregnancy after dropping out from infertility treatments: Evidence from a social survey in Japan	3
Anthropometric measurements of term singletons at 6 years of age born from fresh and frozen embryo transfer: A multicenter prospective study in Japan	3
The gonadotropins starting dose calculator, which can be adjusted the target number of oocytes and stimulation duration days to achieve individualized controlled ovarian stimulation in Japanese patien	3
The morphokinetics algorithm based on data from day 5 blastocyst transfer (KIDScoreD5 version 3) is also useful for embryo selection in day 6 blastocyst transfer	3
Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer	3
Impact of administering umbilical cord‐derived mesenchymal stem cells to cynomolgus monkeys with endometriosis	3
Current status of genome‐wide epigenetic profiling of mammalian preimplantation embryos	3
Embryos, cancers, and parasites: Potential applications to the study of reproductive biology in view of their similarity as biological phenomena	3
Clinical outcome of intrauterine infusion of platelet‐rich plasma in patients with recurrent implantation failure	3
Influence of laparoscopic surgery for endometriosis and its recurrence on perinatal outcomes	3
Predicting implantation by using dual AI system incorporating three‐dimensional blastocyst image and conventional embryo evaluation parameters—A pilot study	2
Kisspeptin neurons as an integration center of reproductive regulation: Observation of reproductive function based on a new concept of reproductive regulatory nervous system	2
Sex difference in anti‐sperm antibodies	2
A new clustering model based on the seminal plasma/serum ratios of multiple trace element concentrations in male patients with subfertility	2
Analysis of cell–cell interaction between mural granulosa cells and cumulus granulosa cells during ovulation using single‐cell RNA sequencing data of mouse ovary	2
Unexplained infertility categorization based on female laparoscopy and total motile sperm count, and its impact on cumulative live‐births after one in‐vitro fertilization cycle. A retrospective cohort	2
Metabolomic and microbiome analysis of cervicovaginal mucus in in vitro fertilization–embryo transfer: Toward predicting pregnancy success	2
The number of previous implantation failures is a critical determinant of intrauterine autologous platelet‐rich plasma infusion success in women with recurrent implantation failure	2
Age, sexual abstinence duration, sperm morphology, and motility are predictors of sperm DNA fragmentation	2
Expression and co‐localization of RFRP‐3 and kisspeptin during breeding and non‐breeding season in the hypothalamus of male rhesus monkey (Macaca mulatta)	2
From lessons on the long‐term effects of the preimplantation environment on later health to a “modified ART‐DOHaD” animal model	2
The novel oral gonadotropin‐releasing hormone receptor antagonist relugolix is a new option for controlled ovarian stimulation cycles	2
A review of the optimization of thyroid function, thrombophilia, immunity and uterine milieu: OPTIMUM treatment strategy for recurrent implantation failure and recurrent pregnancy loss	2
Polycystic ovary syndrome: Criteria, phenotypes, race and ethnicity	2
Age‐dependent phenotypes of ovarian endometriomas	2
Endometrial pattern predicts pregnancy outcome in single‐blastocyst frozen‐embryo transfer: An analysis of 1383 cycles	2
Novel erectile analyses revealed augmentable penile Lyve‐1, the lymphatic marker, expression	2
Occurrence of chronic endometritis in different types of human adenomyosis	2
Increased risk of obstetric complications in patients with adenomyosis: A narrative literature review	2
Influence of a patient education and care program on women undergoing non‐assisted reproductive technology fertility treatment	2
Roles of lipid mediators in early pregnancy events	2
Non‐medical oocyte cryopreservation at a single center in Japan: 8 years of experience	2
Molecular mechanisms of mammalian sperm capacitation, and its regulation by sodium‐dependent secondary active transporters	2
Potential for artificial intelligence in medicine and its application to male infertility	2
Risk factors for non‐previa placenta accreta spectrum in pregnancies conceived through frozen embryo transfer during a hormone replacement cycle in Japan	2