Clinical Chemistry and Laboratory Medicine

Article	Citations
Performance of the 2009 CKDEPI, 2021 CKDEPI, and EKFC equations among high-risk patients in Denmark	134
Plenary 4 - Diagnostic advances in dementia	123
Analytical performance specifications for trace elements in biological fluids derived from six countries federated external quality assessment schemes over 10 years	107
COVID-19	87
7th EFLM Conference on Preanalytical Phase	73
EN ISO 15189 revision: EFLM Committee Accreditation and ISO/CEN standards (C: A/ISO) analysis and general remarks on the changes	73
Diagnostic performance of machine learning models using cell population data for the detection of sepsis: a comparative study	66
Overcoming challenges regarding reference materials and regulations that influence global standardization of medical laboratory testing results	64
Discriminating signal from noise: the biological variation of circulating calprotectin in serum and plasma	61
Cell population data: much more to explore	59
Behind the scenes of EQA – characteristics, capabilities, benefits and assets of external quality assessment (EQA): Part II – EQA cycles	58
An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for the quantification of aldosterone in human serum and plasma	55
Quantification of blood glial fibrillary acidic protein using a second-generation microfluidic assay. Validation and comparative analysis with two established assays	51
Analytical interference of intravascular contrast agents with clinical laboratory tests: a joint guideline by the ESUR Contrast Media Safety Committee and the Preanalytical Phase Working Group of the	50
Acetylcholine receptor and muscle-specific tyrosine kinase antibodies detection: is it time for a change?	49
Design of an algorithm for the detection of intravenous fluid contamination in clinical laboratory samples	47
Evaluation of the analytical and clinical performance of a new high-sensitivity cardiac troponin I assay: hs-cTnI (CLIA) assay	45
SYMPOSIUM 7 - Medical test standardization in the era of Metrological Traceability: who is accountable?	44
Multiplex proteomics using proximity extension assay for the identification of protein biomarkers predictive of acute graft-vs.-host disease in allogeneic hematopoietic cell transplantation	44
ROUND-TABLE 1 - Beyond the Numbers: Integrating Laboratory and Clinical Perspectives on Thyroid Health	43
Frontmatter	42
Presence of SARS-CoV-2 RNA in COVID-19 survivors with post-COVID symptoms: a systematic review of the literature	41
Small-scale external quality assessment of methylated SHOX2 and RASSF1A detection in China: findings from	40
Stability of different biochemical parameters in pooled left-over sera stored for 14 days after pooling either at room temperature or at 2–10 °C	37
Implementation of AI systems in the clinical laboratory: insights from an expert survey and recommendations for best practice	37

Diagnostic performance of a point of care high-sensitivity cardiac troponin I assay and single measurement evaluation to rule out and rule in acute coronary syndrome	36
Multicenter study to compare the diagnostic performance of CLIA vs. FEIA transglutaminase IgA assays for the diagnosis of celiac disease	35
Not all biases are created equal: how to deal with bias on laboratory measurements	35
From assessment to action: experience from a quality improvement initiative integrating indicator evaluation and adverse event analysis in a clinical laboratory	34
Results of a SARS-CoV-2 virus genome detection external quality assessment round focusing on sensitivity of assays and pooling of samples	34
Insight into the status of plasma renin and aldosterone measurement: findings from 526 clinical laboratories in China	34
Measurement uncertainty estimation of free drug concentrations in clinical laboratories using equilibrium dialysis	34
Toward neonatal analytical stewardship: building on Cadamuro et al.’s minimum-volume framework	33
Machine learning-based delta check method for detecting misidentification errors in tumor marker tests	33
Moving average quality control of routine chemistry and hematology parameters – a toolbox for implementation	33
Serum protein electrophoresis pattern associated with elevated polyclonal IgG4 concentrations: a monoclonal-mimicking profile with potentially significant clinical implications	31
An automatic chemiluminescence immunoassay for a novel biomarker NT-IGFBP-4: analytical performance and clinical relevance in heart failure	31
Annual meeting of the Royal Belgian Society of Laboratory Medicine (RBSLM): “Beyond the Surface – Clinical biology of the apparently healthy individual”	30
Serial measurement of circulating calprotectin as a prognostic biomarker in COVID-19 patients in intensive care setting	29
Personalized reference intervals based on biological variation: a critical evaluation of strengths and limitations	29
Laboratory quality indicators: persistent variability despite international harmonization efforts	29
Differences in laboratory reporting of thyroglobulin antibody positivity – a national survey across laboratories in the Netherlands	29
Interference of therapeutic monoclonal antibodies with electrophoresis and immunofixation of serum proteins: state of knowledge and systematic review	28
Web-accessible critical limits and critical values for urgent clinician notification	28
A novel LC-MS/MS-based assay for the simultaneous quantification of aldosterone-related steroids in human urine	28
Evaluation of biochemical algorithms to screen dysbetalipoproteinemia in ε2ε2 and rare APOE variants carriers	27
Frontmatter	27
Long-term effects of interventions applied to optimize the use of 25-OH vitamin D tests in primary health care	26
Familial dysalbuminemic hyperthyroxinemia coexisting with a Grave’s disease: a Belgian case report	26
Use of the term “Bence-Jones proteinuria” in the EFLM European Urinalysis Guideline 2023	26
Pseudohyperglycemia due to glucometer interference in galactosemia	26
Linearity assessment: deviation from linearity and residual of linear regression approaches	25
SYMPOSIUM 1 - New approaches for deriving and applying biological variation data for clinical use	24
A single dose of 20-mg of ostarine is detectable in hair	24
Kidney diseases and transplantation, urinanalysis	24
The impact of COVID-19 on citations of laboratory medicine journals	24
Contents	24
The 10+1 Santorini Conference	24
A step forward in pediatric hemophagocytic lymphohistiocytosis and autoimmune disease: pediatric reference interval for serum soluble IL-2 receptor and soluble CD163	24
External quality assurance (EQA): navigating between quality and sustainability	24
Precision Medicine	24
Biological matrices, reagents and turnaround-time: the full-circle of artificial intelligence in the pre-analytical Phase. Comment on Turcic A, et al., Machine learning to optimize cerebrospinal fluid	24
Clinical utility of personalized reference intervals for CEA in the early detection of oncologic disease	23
Frontmatter	23
Serum sPD-L1 levels are elevated in patients with viral diseases, bacterial sepsis or in patients with impaired renal function compared to healthy blood donors	23
ISMD2024 Thirteenth International Symposium on Molecular Diagnostics	23
From ordering to interpretation: a comprehensive framework for laboratory test indications	23
Clinical evidence requirements according to the IVDR 2017/746: practical tools and references for underpinning clinical evidence of IVD-MDs	23
Comprehensive evaluation of antiphospholipid antibody testing methodologies in APS diagnosis: performance comparisons across assay systems and clinical subtypes	22
Emerging technology: a definition for laboratory medicine	22
What Matters Most: an Age-Friendly approach to pathology and laboratory medicine	22
Response to Tony Badrick regarding “Letter to the Editor regarding the article by Wayne J. Dimech et al. Time to address quality control processes applied to antibody testing for infectious diseases.	22
Epigenetic signatures of cfDNA enable a topological assignment of tissue damage	22
Biomarkers to measure the need and the effectiveness of therapeutic supplementation: a critical issue	21
Science, Quality and Value of Laboratory Medicine	21

Drainage fluid LDH and neutrophil to lymphocyte ratio as biomarkers for early detecting anastomotic leakage in patients undergoing colorectal surgery	21
Dynamics of the vitamin D C3-epimer levels in preterm infants	20
Quality in laboratory medicine and the Journal: walking together	20
Age- and sex-specific reference intervals for 11-oxygenated androgens from infancy throughout childhood and adulthood	20
HTA model for laboratory medicine technologies: overview of approaches adopted in some international agencies	20
Laboratory response to paradigm change in hemophilia treatment	20
An improved implementation of metrological traceability concepts is needed to benefit from standardization of laboratory results	20
Colorimetric correcting for sample concentration in stool samples	20
Concordance between the updated Elecsys cerebrospinal fluid immunoassays and amyloid positron emission tomography for Alzheimer’s disease assessment: findings from the Apollo study	20
Greater expectations: meeting clinical needs through broad and rapid genomic testing	20
One fits all: a highly sensitive combined ddPCR/pyrosequencing system for the quantification of microchimerism after hematopoietic and solid organ transplantation	20
Analytical evaluation of the novel Mindray high sensitivity cardiac troponin I immunoassay on CL-1200i	19
Pseudo-erythroblastosis on Sysmex XN hematology analyzers: a clue to Candida sepsis. Case report and literature review	19
IgG and kappa free light chain CSF/serum indices: evaluating intrathecal immunoglobulin production in HIV infection in comparison with multiple sclerosis	19
Comparison of near-infrared and UV–vis-based non-contact hematocrit prediction of dried blood spots from patients on immunosuppressants	19
Analytical performance specifications – moving from models to practical recommendations	19
IgA rheumatoid factor in rheumatoid arthritis	19
Refining within-subject biological variation estimation using routine laboratory data: practical applications of the refineR algorithm	19
An isotope dilution-liquid chromatography-tandem mass spectrometry based candidate reference measurement procedure for the simultaneous quantification of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2	19
Stability of plasma renin concentration based on plasma freezing time, as an adjunct to the stability data reported in the paper by Hepburn and others	18
Neonatal reference intervals for serum steroid hormone concentrations measured by LC-MS/MS	18
The role of analytical performance specifications in international guidelines and standards dealing with metrological traceability in laboratory medicine	18
Reply: Be aware of legally required metrology and higher-order reference measurement services run in calibration laboratories	18
Evaluation of effects from hemoglobin variants on HbA1c measurements by different methods	17
A scientific comparison of the EFLM Vision and RiskGATOR software: a unified path towards value-based, patient-centered laboratory medicine	17
Artificial intelligence in clinical applications for lung cancer: diagnosis, treatment and prognosis	17
Remote monitoring and preanalytical challenges	17
Regulating the future of laboratory medicine: European regulatory landscape of AI-driven medical device software in laboratory medicine	17
Strategy of Laboratory Medicine – EFLM Vision	17
Reporting of pre-analytical variables affecting the determination of brain-derived neurotrophic factor (BDNF) in patients with stroke: a scoping review	17
Frontmatter	17
Metrological traceability and test standardization/harmonization	17
Cell population data for early detection of sepsis in patients with suspected infection in the emergency department	17
Biological variation of serum cholinesterase activity in healthy subjects	17
Diabetes, obesity, metabolic syndrome	17
Serous body fluid evaluation using the new automated haematology analyser Mindray BC-6800Plus	17
The preanalytical process in the emergency department, a European survey	16
Clinical evaluation of the OC-Sensor Pledia calprotectin assay	16
From venipuncture to self-sampling dried blood spots: a shift in monitoring testosterone levels	16
An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure for the quantification of carbamazepine-10,11-epoxide in human serum an	16
A new milestone on the road to global standardization of apolipoprotein measurements	16
Understanding the limitations of your assay using EQA data with serum creatinine as an example	16
Validation and verification framework and data integration of biosensors and in vitro diagnostic devices: a position statement of the IFCC Committee on Mobile Health and Bioengineering in Labor	16
Frontmatter	16
Performance evaluation and user experience of BT-50 transportation unit with automated and scheduled quality control measurements	16
Evaluation of the interchangeability between the new fully-automated affinity chrome-mediated immunoassay (ACMIA) and the Quantitative Microsphere System (QMS) with a CE-IVD-certified LC-MS/MS assay f	16
Copeptin as a diagnostic and prognostic biomarker in pediatric diseases	16
In-house diagnostic devices under the EU IVDR and unwanted side-effects of intentional transparency	16
Comparison between polynomial regression and weighted least squares regression analysis for verification of analytical measurement range	16
The role of Killer immunoglobulin-like receptors (KIRs) in the genetic susceptibility to non-celiac wheat sensitivity (NCWS)	16
‘Penelope test’: a practical instrument for checking appropriateness of laboratory tests	16
Annual meeting of the Royal Belgian Society of Laboratory Medicine: “Symphony of the Heart”	16
Estimation of the reference values and decision limits for growth hormone in newborns using dried blood spots	16
Reply to: “Accurate predictory role of monocyte distribution width on short-term outcome in sepsis patients”	16
Improving regional medical laboratory center report quality through a report recall management system	16
Reviewer Acknowledgment	16
Flow-cytometric lymphocyte subsets enumeration: comparison of single/dual-platform method in clinical laboratory with dual-platform extended PanLeucogating method in reference laboratory	16
Assessing the clinical applicability of dimensionality reduction algorithms in flow cytometry for hematologic malignancies	16
A physio-chemical mathematical model of the effects of blood analysis delay on acid-base, metabolite and electrolyte status: evaluation in blood from critical care patients	16
Influence of remnant cholesterol on direct LDL and HDL cholesterol measurement accuracy	15
Limitations of glycated albumin standardization when applied to the assessment of diabetes patients	15
Accurate stratification between VEXAS syndrome and differential diagnoses by deep learning analysis of peripheral blood smears	15
Combining the calibrator uncertainty and the long-term measurement uncertainty? A comment to the ISO/TS 20914 guideline	15
Is it feasible for European laboratories to use SI units in reporting results?	15
Quality indicators: an evolving target for laboratory medicine	15
The first case of Teclistamab interference with serum electrophoresis and immunofixation	15
Association of prehospital lactate levels with base excess in various emergencies – a retrospective study	15
Diagnostic accuracy of TIMP-2 and IGFBP7 for detecting acute kidney injury in adult intensive care unit patients: a systematic review and meta-analysis	15
The biological variation of insulin resistance markers: data from the European Biological Variation Study (EuBIVAS)	15
Urine transfer devices may impact urinary particle results: a pre-analytical study	15
Urinary aldosterone and tetrahydroaldosterone by LC-MS/MS with enzymatic hydrolysis: validation and age-stratified reference intervals	15
Estimation of the allowable total error of the absolute CD34+ cell count by flow cytometry using data from UK NEQAS exercises 2004–2024	14
Unraveling the mystery of blood groups and COVID-19	14
Improved implementation of medical tests – barriers and opportunities	14
Setting analytical performance specifications for copeptin-based testing	14
Differences between high-sensitivity cardiac troponin T and I in stable populations: underlying causes and clinical implications	14
Variations in tumor growth, intra-individual biological variability, and the interpretation of changes	14
Kinetics and ability of binding antibody and surrogate virus neutralization tests to predict neutralizing antibodies against the SARS-CoV-2 Omicron variant following BNT162b2 booster administration	14
Diagnosis of IRAK-4-deficiency by flow cytometric measurement of IκB-α degradation	14
Assessing the harmonization of current total vitamin B12 measurement methods: relevance and implications	14

Preanalytical phase	14
Striving for a pragmatic contribution of biomarkers results to lifelong health care	14
Where is laboratory medicine headed in the next decade? Partnership model for efficient integration and adoption of artificial intelligence into medical laboratories	14
Six years of progress – highlights from the IFCC Emerging Technologies Division	13
Nutrition Trace Elements and Vitamins	13
Diagnostic accuracy of extended HPV DNA genotyping and its application for risk-based cervical cancer screening strategy	13
Performance of GFAP and UCH-L1 compared to S100B in detecting intracranial injury: influence of age, hemolysis, neurodegenerative diseases, and extracranial fractures in a prospective cohort of over 1	13
Clinical implication by differential analytical performances of serum free light chain quantitation analysis using fully automated analyzers	13
Arivale is dead ‒ Hooke is alive	13
Transport stability profiling – a proposed generic protocol	13
Precise glucose measurement in sodium fluoride-citrate plasma affects estimates of prevalence in diabetes and prediabetes	13
Comparison between free β subunit of human chorionic gonadotropin (hCG) and total hCG assays in adults with testicular cancer	13
Testosterone analysis in castrated prostate cancer patients: suitability of the castration cut-off and analytical accuracy of the present-day clinical immunoassays	13
Early autoimmune signature in a young woman: palmar erythema, capillaroscopic abnormalities, and triple autoantibody positivity including anti-nucleosome	13
Histamine metabolite to basal serum tryptase ratios in systemic mastocytosis and hereditary alpha tryptasemia using a validated LC-MS/MS approach	13
Ct values of different SARS CoV2 variants: a single center observational study from Innsbruck, Austria	13
Diagnostic accuracy of adenosine deaminase for tuberculous pleural effusion: age does matter	13
Performance evaluation of the introduction of full sample traceability system within the specimen collection process	12
A survey on Artificial Intelligence and Big Data utilisation in Italian clinical laboratories	12
An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of cortisol in human urine	12
Salivary testosterone reference intervals for adult women and men	12
Evidence-based procedures to improve the reliability of circulating miRNA biomarker assays	12
Reshaping laboratory medicine through technological advances	12
Clostebol detection after transdermal and transmucosal contact. A systematic review	12
Tafasitamab interference in immunofixation electrophoresis	12
Novel protocol for metabolomics data normalization and biomarker discovery in human tears	12
Inconsistency in ferritin reference intervals across laboratories: a major concern for clinical decision making	12
The ARRplus : a model for renin-dependent and sex-specific aldosterone cut-offs that improves screening for primary aldosteronism	12
SARS CoV-2 spike protein-guided exosome isolation facilitates detection of potential miRNA biomarkers in COVID-19 infections	12
A model for managing quality control for a network of clinical chemistry instruments measuring the same analyte	12
Evidence for stability of cardiac troponin T concentrations measured with a high sensitivity TnT test in serum and lithium heparin plasma after six-year storage at −80 °C and multiple freeze-thaw cycl	12
Tumor markers determination in malignant pleural effusion: pearls and pitfalls	12
Artificial intelligence, clinical decision support and machine learning	12
Reference intervals of circulating secretoneurin concentrations determined in a large cohort of community dwellers: the HUNT study	12
Biological variation of serum Golgi protein 73 concentrations	12
Contribution of SuPAR for patients in a situation of uncertainty downstream of emergencies	12
The routine coagulation assays plasma stability – in the wake of the new European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) biological variability database	12
Can we identify patients carrying targeted deleterious DPYD variants with plasma uracil and dihydrouracil? A GPCO-RNPGx retrospective analysis	11
Symposium 13 - Prenatal testing	11
Biological variation of serum iron from the European biological variation study (EuBIVAS)	11
Searching for the urine osmolality surrogate: an automated machine learning approach	11
Analytical and clinical evaluations of Snibe Maglumi® S100B assay	11
First-trimester screening for Down syndrome using quadruple maternal biochemical markers	11
Standardization challenges in antipsychotic drug monitoring: insights from a national survey in Chinese TDM practices	11
Diagnostic performance of Mindray CL1200i high sensitivity cardiac troponin I assay compared to Abbott Alinity cardiac troponin I assay for the diagnosis of type 1 and 2 acute myocardial infarction in	11
Spurious parathyroid hormone (PTH) elevation caused by macro-PTH	11
Sepsis	11
16ª Reunião Científica da Sociedade Portuguesa de Medicina Laboratorial - SPML	11
The effects of drone transportation on routine laboratory, immunohematology, flow cytometry and molecular analyses	11
An appeal for biological variation estimates in deep immunophenotyping	11
Association of circulating free and total oxysterols in breast cancer patients	11
The journey to pre-analytical quality	11
The total testing process harmonization: the case study of SARS-CoV-2 serological tests	11
Chemical strategies for sustainable medical laboratories	11
Frontmatter	11
M-protein diagnostics in multiple myeloma patients using ultra-sensitive targeted mass spectrometry and an off-the-shelf calibrator	11
A novel immunoprecipitation-based targeted liquid chromatography-tandem mass spectrometry analysis for accurate determination for copeptin in human serum	11
Is uracil enough for effective pre-emptive DPD testing?	11
Patient risk management in laboratory medicine: an international survey to assess the severity of harm associated with erroneous reported results	11
An appraisal of the practice of duplicate testing for the detection of irregular analytical errors	10
Impact of different preservation methods on urinary red blood cell counts	10
Serum biomarkers of remodeling in severe asthma with fixed airway obstruction and the potential role of KL-6	10
Evaluating the performance of a multiparametric IgA assay for celiac disease diagnosis	10
Toxicology and TDM	10
Validation of (self-collected) capillary blood using a topper collection system as alternative for venous sampling for 15 common clinical chemistry analytes	10
IFCC Symposium - Advancing Excellence in Laboratory Medicine Worldwide: An Update from IFCC Taskforces	10
Two cases of MTHFR C677T polymorphism typing failure by Taqman system due to MTHFR 679 GA heterozygous mutation	10
Biotin interference in immunoassays: water under the bridge?	10
Detection of urinary foam cells diagnosing the XGP with thrombopenia preoperatively: a case report	10
Is this a true lambda free light chain?	10
At-home blood collection for clinical chemistry analyses in a kidney transplant population: a feasibility study	10
Correction of negative-interference from calcium dobesilate in the Roche sarcosine oxidase creatinine assay using CuO	10
Positivization time of a COVID-19 rapid antigen self-test predicts SARS-CoV-2 viral load: a proof of concept	10
Interference with immunofixation in a dabigatran-overdosed patient treated with idarucizumab: beware of a diagnostic pitfall	10
Traceable machine learning real-time quality control based on patient data	10
Tutorial: statistical methods for the meta-analysis of diagnostic test accuracy studies	10
Serum free light chain analysis: persisting limitations with new kids on the block	10
Point of Care testing, critical care, emergency medicine	10
Lot-to-lot bias for high-sensitivity cardiac troponin I concentrations ≥1000 ng/L	10
Analytical performance specifications based on biological variation data – considerations, strengths and limitations	10
Comparison of the cardiac troponin I-cardiac troponin T-troponin C complex and cardiac troponin I and T in distinguishing myocardial infarction using a single sample at presentation	10
The simple reproducibility of a measurement result does not equal its overall measurement uncertainty	10
Using artificial intelligence in a primary care setting to identify patients at risk for cancer: a risk prediction model based on routine laboratory tests	10
Immunology	10
C-terminal alpha-1-antitrypsin peptides as novel predictor of hospital mortality in critically ill COVID-19 patients	10
An overview of the most important preanalytical factors influencing the clinical performance of SARS-CoV-2 antigen rapid diagnostic tests (Ag-RDTs)	10
Macroprolactinaemia – some progress but still an ongoing problem	10
Reconciling reference ranges and clinical decision limits: the case of thyroid stimulating hormone	10
Allowable total error in CD34 cell analysis by flow cytometry based on state of the art using Spanish EQAS data	10
Frontmatter	10
Practical delta check limits for tumour markers in different clinical settings	9
EFLM Symposium - Precision Medicine	9
Presepsin levels in neonatal cord blood are not influenced by maternal SARS-CoV-2 infection	9
Point-of-care testing: state-of-the art and perspectives	9
Anti-Ki/anti-PA28γ autoantibodies contribute to the HEp-2 indirect immunofluorescence nuclear speckled pattern	9