Biological Chemistry

Article	Citations
Antibody display technologies: selecting the cream of the crop	78
3-Mercaptopyruvate sulfurtransferase: an enzyme at the crossroads of sulfane sulfur trafficking	56
Kill one or kill the many: interplay between mitophagy and apoptosis	47
Shifting paradigms and novel players in Cys-based redox regulation and ROS signaling in plants - and where to go next	47
Acute-phase protein synthesis: a key feature of innate immune functions of the liver	44
Regulation of DEAH-box RNA helicases by G-patch proteins	44
Human islet amyloid polypeptide (hIAPP) - a curse in type II diabetes mellitus: insights from structure and toxicity studies	37
Metabolism of non-growing bacteria	36
Thiol switches in membrane proteins - Extracellular redox regulation in cell biology	35
The role of very long chain fatty acids in yeast physiology and human diseases	34
Unexpected metabolic versatility among type II methanotrophs in the Alphaproteobacteria	34
Thiol-based redox switches in the major pathogen Staphylococcus aureus	32
Glutaredoxins and iron-sulfur protein biogenesis at the interface of redox biology and iron metabolism	32
Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins	31
Emerging roles for non-selenium containing ER-resident glutathione peroxidases in cell signaling and disease	31
The ups and downs of ectoine: structural enzymology of a major microbial stress protectant and versatile nutrient	31
Brothers in arms: proBDNF/BDNF and sAPPα/Aβ-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of Alzheimer’s disease	28
Redox-dependent and independent effects of thioredoxin interacting protein	25
Glutamine synthetase as a central element in hepatic glutamine and ammonia metabolism: novel aspects	24
RNA secondary structure dependence in METTL3–METTL14 mRNA methylation is modulated by the N-terminal domain of METTL3	24
Redox regulation in host-pathogen interactions: thiol switches and beyond	24
Starting the engine of the powerhouse: mitochondrial transcription and beyond	24
Multicellular and unicellular responses of microbial biofilms to stress	23
Chemerin – exploring a versatile adipokine	23
Myricetin protects pancreatic β-cells from human islet amyloid polypeptide (hIAPP) induced cytotoxicity and restores islet function	22

Pathomechanisms in hepatic encephalopathy	21
A guide to designing photocontrol in proteins: methods, strategies and applications	21
Diversity of GPI-anchored fungal adhesins	21
Detecting myocardial scar using electrocardiogram data and deep neural networks	20
Biosynthesis and function of cell-surface polysaccharides in the social bacterium Myxococcus xanthus	20
Regulation of RNA helicase activity: principles and examples	20
Investigation of the structure of regulatory proteins interacting with glycosaminoglycans by combining NMR spectroscopy and molecular modeling – the beginning of a wonderful friendship	19
Hsa-miR-186-5p regulates TGFβ signaling pathway through expression suppression of SMAD6 and SMAD7 genes in colorectal cancer	19
Membrane damage and repair: a thin line between life and death	19
A primer on heme biosynthesis	19
Hepatic stellate cells: current state and open questions	18
LOTUS-domain proteins - developmental effectors from a molecular perspective	18
Collagen/glycosaminoglycan-based matrices for controlling skin cell responses	18
Dead or alive: DEAD-box ATPases as regulators of ribonucleoprotein complex condensation	17
Biochemical unity revisited: microbial central carbon metabolism holds new discoveries, multi-tasking pathways, and redundancies with a reason	17
The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes	16
Post-translational lysine ac(et)ylation in health, ageing and disease	16
iMLP, a predictor for internal matrix targeting-like sequences in mitochondrial proteins	16
Thiol-based switching mechanisms of stress-sensing chaperones	15
Cyclic di-GMP signaling controlling the free-living lifestyle of alpha-proteobacterial rhizobia	15
Transfer RNA processing – from a structural and disease perspective	15
Revisiting the interaction of heme with hemopexin	15
Targeting spectrin redox switches to regulate the mechanoproperties of red blood cells	14
Irisin ameliorates endoplasmic reticulum stress and liver fibrosis through inhibiting PERK-mediated destabilization of HNRNPA1 in hepatic stellate cells	14
New insights into the role of glycosaminoglycans in the endosteal bone microenvironment	14
Generating asymmetry in a changing environment: cell cycle regulation in dimorphic alphaproteobacteria	14
STAT3 promotes peritoneal metastasis of gastric cancer by enhancing mesothelial-mesenchymal transition	14
Regulation of RNA stability at the 3′ end	14
TFAP2A-induced SLC2A1-AS1 promotes cancer cell proliferation	14
Chemically modified glycosaminoglycan derivatives as building blocks for biomaterial coatings and hydrogels	13
The role of mycotoxins in neurodegenerative diseases: current state of the art and future perspectives of research	13
Heme delivery to heme oxygenase-2 involves glyceraldehyde-3-phosphate dehydrogenase	13
Genetically encoded thiol redox-sensors in the zebrafish model: lessons for embryonic development and regeneration	13
Genomic insights into cyanobacterial protein translocation systems	12
Mtr4 RNA helicase structures and interactions	12
HDAC8 promotes daunorubicin resistance of human acute myeloid leukemia cells via regulation of IL-6 and IL-8	12
Structures and nucleic acid-binding preferences of the eukaryotic ARID domain	12
New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals	11
Expansion and inflammation of white adipose tissue - focusing on adipocyte progenitors	11
Thioredoxin-dependent control balances the metabolic activities of tetrapyrrole biosynthesis	11
The emerging role of ATP as a cosolute for biomolecular processes	10
CERKL alleviates ischemia reperfusion-induced nervous system injury through modulating the SIRT1/PINK1/Parkin pathway and mitophagy induction	10
Rational approaches towards inorganic and organometallic antibacterials	10
PCAT1 induced by transcription factor YY1 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-216a-3p to up-regulate oncogene BCL3	10
Spatial organization enhances versatility and specificity in cyclic di-GMP signaling	10
Regulation of transforming growth factor-β1-stimulation of Runx2 acetylation for matrix metalloproteinase 13 expression in osteoblastic cells	10
Elucidating the anti-biofilm and anti-quorum sensing potential of selenocystine against respiratory tract infections causing bacteria: in vitro and in silico studies	10
Improvement of wound healing by the development of ECM-inspired biomaterial coatings and controlled protein release	10
DDX41: a multifunctional DEAD-box protein involved in pre-mRNA splicing and innate immunity	10
Pseudomonas aeruginosa and Staphylococcus aureus virulence factors as biomarkers of infection	10

Structural insights into the modulation of PDGF/PDGFR-β complexation by hyaluronan derivatives	10
Emerging contributions of formyl peptide receptors to neurodegenerative diseases	10
Molecular insights into endolysosomal microcompartment formation and maintenance	10
Berberine improves dietary-induced cardiac remodeling by upregulating Kruppel-like factor 4-dependent mitochondrial function	9
The role of host heme in bacterial infection	9
Modulation of macrophage functions by ECM-inspired wound dressings – a promising therapeutic approach for chronic wounds	9
Eukaryotic tRNA splicing – one goal, two strategies, many players	9
Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies	9
Role of the gut microbiota in airway immunity and host defense against respiratory infections	9
Physiology of guanosine-based second messenger signaling in Bacillus subtilis	9
Individual and combined effects of GIP and xenin on differentiation, glucose uptake and lipolysis in 3T3-L1 adipocytes	9
Assessment of the breadth of binding promiscuity of heme towards human proteins	9
Molecular mechanisms of vasculopathy and coagulopathy in COVID-19	9
C-X-C chemokine receptor 2 (Cxcr2) promotes hepatocellular carcinoma immune evasion via regulating programmed death-ligand 1 (PD-L1)	9
Zinc-dependent changes in oxidative and endoplasmic reticulum stress during cardiomyocyte hypoxia/reoxygenation	9
Placental mitochondrial function as a driver of angiogenesis and placental dysfunction	9
Exceptionally versatile take II: post-translational modifications of lysine and their impact on bacterial physiology	9
The paracaspase MALT1 in psoriasis	9
Characterization of a fluorescent 1,8-naphthalimide-functionalized PAMAM dendrimer and its Cu(ii) complexes as cytotoxic drugs: EPR and biological studies in myeloid tumor cells	8
Decreased level of miR-1301 promotes colorectal cancer progression via activation of STAT3 pathway	8
Histone deacetylase 1 regulates the malignancy of oral cancer cells via miR-154-5p/PCNA axis	8
The extracellular region of bovine milk butyrophilin exhibits closer structural similarity to human myelin oligodendrocyte glycoprotein than to immunological BTN family receptors	8
Infection, inflammation and thrombosis: a review of potential mechanisms mediating arterial thrombosis associated with influenza and severe acute respiratory syndrome coronavirus 2	8
The phytochemical plumbagin reciprocally modulates osteoblasts and osteoclasts	8
The role of the Na+/Ca2+-exchanger (NCX) in cancer-associated fibroblasts	8
Effect of myeloperoxidase oxidation and N-homocysteinylation of high-density lipoprotein on endothelial repair function	8
Identification of cytokeratin24 as a tumor suppressor for the management of head and neck cancer	8
Transcription, translation, and DNA repair: new insights from emerging noncanonical substrates of RNA helicases	8
Epithelial-mesenchymal transition and H2O2 signaling – a driver of disease progression and a vulnerability in cancers	8
High cellulose diet promotes intestinal motility through regulating intestinal immune homeostasis and serotonin biosynthesis	8
Vorinostat exhibits anticancer effects in triple-negative breast cancer cells by preventing nitric oxide-driven histone deacetylation	8
The relevance of adhesion G protein-coupled receptors in metabolic functions	8
Apolipoprotein C-II and C-III preferably transfer to both high-density lipoprotein (HDL)2 and the larger HDL3 from very low-density lipoprotein (VLDL)	8
Interaction of nucleoporins with nuclear transport receptors: a structural perspective	8
Rapid metabolic and bioenergetic adaptations of astrocytes under hyperammonemia – a novel perspective on hepatic encephalopathy	7
Glycation of benign meningioma cells leads to increased invasion	7
Loss of respiratory complex I subunit NDUFB10 affects complex I assembly and supercomplex formation	7
Tissue factor pathway inhibitor 2 is a potent kallikrein-related protease 12 inhibitor	7
Characterization of the scavenger cell proteome in mouse and rat liver	7
Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry	7
Machine learning based disease prediction from genotype data	7
M6A methylation-mediated elevation of SM22α inhibits the proliferation and migration of vascular smooth muscle cells and ameliorates intimal hyperplasia in type 2 diabetes mellitus	7
Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators	7
Role of vasodilation in liver regeneration and health	6
Long non-coding RNA FAM66C regulates glioma growth via the miRNA/LATS1 signaling pathway	6
Neuronal stress granules as dynamic microcompartments: current concepts and open questions	6
Expanded profiling of β-lactam selectivity for penicillin-binding proteins in Streptococcus pneumoniae D39	6
Nitazoxanide inhibits osteosarcoma cells growth and metastasis by suppressing AKT/mTOR and Wnt/β-catenin signaling pathways	6
TRPM3 in the eye and in the nervous system – from new findings to novel mechanisms	6
The DHX36-specific-motif (DSM) enhances specificity by accelerating recruitment of DNA G-quadruplex structures	6
Direct comparison of the immunogenicity of major histocompatibility complex-I and -II deficient mesenchymal stem cells in vivo	6
Integrated Ca2+ flux and AFM force analysis in human iPSC-derived cardiomyocytes	6
The many facets of bile acids in the physiology and pathophysiology of the human liver	6
Unification of functional annotation descriptions using text mining	6
A biochemical view on the septins, a less known component of the cytoskeleton	6
Determination of free heme in stored red blood cells with an apo-horseradish peroxidase-based assay	6
Human glucose-dependent insulinotropic polypeptide (GIP) is an antimicrobial adjuvant re-sensitising multidrug-resistant Gram-negative bacteria	6
Good things come to those who bait: the peroxisomal docking complex	6
Prediction and analysis of redox-sensitive cysteines using machine learning and statistical methods	6
Autophagic and non-autophagic functions of the Saccharomyces cerevisiae PROPPINs Atg18, Atg21 and Hsv2	6
Nuclear redox processes in land plant development and stress adaptation	6
LINC00520 up-regulates SOX5 to promote cell proliferation and invasion by miR-4516 in human hepatocellular carcinoma	6
Altered population activity and local tuning heterogeneity in auditory cortex of Cacna2d3-deficient mice	6
Illuminating the brain-genetically encoded single wavelength fluorescent biosensors to unravel neurotransmitter dynamics	6
LncRNA-p21 suppresses cell proliferation and induces apoptosis in gastric cancer by sponging miR-514b-3p and up-regulating ARHGEF9 expression	6
Astrocytic potassium and calcium channels as integrators of the inflammatory and ischemic CNS microenvironment	6
Membrane-anchored substrate binding proteins are deployed in secondary TAXI transporters	5
Mediator structure and function in transcription initiation	5
Drug development for neurodegenerative diseases	5
The cAMP responsive element modulator (CREM) is a regulator of CD4+ T cell function	5
Dynamics of the translocation pore of the human peroxisomal protein import machinery	5
Lefty A is involved in sunitinib resistance of renal cell carcinoma cells via regulation of IL-8	5
Lysine acetyltransferase Tip60 acetylates the APP adaptor Fe65 to increase its transcriptional activity	5
Structural insights into the repair mechanism of AGT for methyl-induced DNA damage	5
Human RecQ helicases in transcription-associated stress management: bridging the gap between DNA and RNA metabolism	5
Carotenoids in Sporidiobolus pararoseus ameliorate diabetic nephropathy in mice through attenuating oxidative stress	5
Comparison of human PEX knockout cell lines suggests a dual role of PEX1 in peroxisome biogenesis	5
Fibrillar biopolymer-based scaffolds to study macrophage-fibroblast crosstalk in wound repair	5
Membrane binding and pore forming insertion of PEX5 into horizontal lipid bilayer	5
Microtubules as a signal hub for axon growth in response to mechanical force	5

Trispecific antibodies produced from mAb2 pairs by controlled Fab-arm exchange	5
Artificial metalloenzymes in a nutshell: the quartet for efficient catalysis	5
Inhibition of miR-143-3p alleviates myocardial ischemia reperfusion injury via limiting mitochondria-mediated apoptosis	5
The antioxidant Rutin counteracts the pathological impact of α-synuclein on the enteric nervous system in vitro	5
Historic nucleic acids isolated by Friedrich Miescher contain RNA besides DNA	5
Super-resolution microscopy and studies of peroxisomes	5
Identification of novel cardiovascular disease associated metabolites using untargeted metabolomics	5
M2 macrophages-derived exosomal miR-3917 promotes the progression of lung cancer via targeting GRK6	5
The role of ADAM17 during liver damage	5
MicroRNA-6838-5p suppresses the self-renewal and metastasis of human liver cancer stem cells through downregulating CBX4 expression and inactivating ERK signaling	5
Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABAAR density	5
In vitro evolution of myc-tag antibodies: in-depth specificity and affinity analysis of Myc1-9E10 and Hyper-Myc	4
Epitranscriptomic modifications in acute myeloid leukemia: m6A and 2′-O-methylation as targets for novel therapeutic strategies	4
The human long non-coding RNA LINC00941 and its modes of action in health and disease	4
Novel insights into heme binding to hemoglobin	4
Influence of phosphorylation on intermediate filaments	4
In vitro osteogenic activities of sulfated derivative of polysaccharide extracted from Tamarindus indica L.	4
Interactions of Na+/taurocholate cotransporting polypeptide with host cellular proteins upon hepatitis B and D virus infection: novel potential targets for antiviral therapy	4
Optogenetics 2.0: challenges and solutions towards a quantitative probing of neural circuits	4
NMDA receptors – regulatory function and pathophysiological significance for pancreatic beta cells	4
Insights into structure, affinity, specificity, and function of GAG-protein interactions through the chemoenzymatic preparation of defined sulfated oligohyaluronans	4
Determinants of synergistic cell-cell interactions in bacteria	4
The impact of oxytocin on thiol/disulphide and malonyldialdehyde/glutathione homeostasis in stressed rats	4
Drosophila collagens in specialised extracellular matrices	4
A novel NMDA receptor test model based on hiPSC-derived neural cells	4
IL-24 inhibits the malignancy of human glioblastoma cells via destabilization of Zeb1	4
The readily retrievable pool of synaptic vesicles	4
Signal transduction mechanisms in heme-based globin-coupled oxygen sensors with a focus on a histidine kinase (AfGcHK) and a diguanylate cyclase (YddV or EcDosC)	4
The many faces of ribosome translocation along the mRNA: reading frame maintenance, ribosome frameshifting and translational bypassing	4
Functional genomics meta-analysis to identify gene set enrichment networks in cardiac hypertrophy	4
Arrestin-dependent internalization of rhodopsin-like G protein-coupled receptors	4
Men who stare at bone: multimodal monitoring of bone healing	4
Morphological dependent effect of cell-free formed supramolecular fibronectin on cellular activities	4
Modular peptide binders – development of a predictive technology as alternative for reagent antibodies	4
Inhibitory effect of mitoquinone against the α-synuclein fibrillation and relevant neurotoxicity: possible role in inhibition of Parkinson’s disease	4
Nanoscale organization of CaV2.1 splice isoforms at presynaptic terminals: implications for synaptic vesicle release and synaptic facilitation	4
Cytosolic RGG RNA-binding proteins are temperature sensitive flowering time regulators in Arabidopsis	4
TMPRSS13 zymogen activation, surface localization, and shedding is regulated by proteolytic cleavage within the non-catalytic stem region	4
A structural biology view on the enzymes involved in eukaryotic mRNA turnover	4
Distinct conformational and energetic features define the specific recognition of (di)aromatic peptide motifs by PEX14	4
Two are not enough: synthetic strategies and applications of unnatural base pairs	4
Tumor cell lysis and synergistically enhanced antibody-dependent cell-mediated cytotoxicity by NKG2D engagement with a bispecific immunoligand targeting the HER2 antigen	4
Tuning the network charge of biohybrid hydrogel matrices to modulate the release of SDF-1	4
Detection of follicular regions in actin-stained whole slide images of the human lymph node by shock filter	4
Biodegradable macromers for implant bulk and surface engineering	3
Rodent models for mood disorders – understanding molecular changes by investigating social behavior	3
Mycobacterial type VII secretion systems	3
Phosphorylation of the receptor protein Pex5p modulates import of proteins into peroxisomes	3
Biophysical applications in structural and molecular biology	3
Mechanism of hypoxia-induced exosome circ_0051799 regulating the progression of lung adenocarcinoma	3
The role of lysosomes in lipid homeostasis	3
Insights on intermolecular FMN-heme domain interaction and the role of linker length in cytochrome P450cin fusion proteins	3
Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation	3
Structure and phase separation of the C-terminal domain of RNA polymerase II	3
Why do certain cancer cells alter functionality and fuse?	3
Dynamic regulation of eEF1A1 acetylation affects colorectal carcinogenesis	3
Influence of inflammatory processes on thalamocortical activity	3
Bayesian methods in integrative structure modeling	3
Synthesis and biological characterization of a new fluorescent probe for vesicular trafficking based on polyazamacrocycle derivative	3
Unravelling the genetic links between Parkinson’s disease and lung cancer	3
Dihydroartemisinin ameliorates balloon injury-induced neointimal formation through suppressing autophagy in vascular smooth muscle cells	3
RBPome identification in egg-cell like callus of Arabidopsis	3
Characterization of hepatic zonation in mice by mass-spectrometric and antibody-based proteomics approaches	3
L-theanine induces skeletal muscle fiber type transformation by activation of prox1/CaN signaling pathway in C2C12 myotubes	3
Protein transport along the presequence pathway	3
On the reproducibility of enzyme reactions and kinetic modelling	3
Structural basis of Alzheimer β-amyloid peptide recognition by engineered lipocalin proteins with aggregation-blocking activity	3
How to draw the line – Raman spectroscopy as a tool for the assessment of biomedicines	3
Pancreatic KCa3.1 channels in health and disease	3