Biological Chemistry

Article	Citations
Antibody display technologies: selecting the cream of the crop	65
3-Mercaptopyruvate sulfurtransferase: an enzyme at the crossroads of sulfane sulfur trafficking	48
Lipid homeostasis in mitochondria	45
Kill one or kill the many: interplay between mitophagy and apoptosis	43
From the discovery to molecular understanding of cellular iron-sulfur protein biogenesis	41
Shifting paradigms and novel players in Cys-based redox regulation and ROS signaling in plants - and where to go next	41
Regulation of DEAH-box RNA helicases by G-patch proteins	36
From cytosol to mitochondria: the beginning of a protein journey	35
From TOM to the TIM23 complex – handing over of a precursor	35
Evolution of mitochondrial protein import – lessons from trypanosomes	33
LncRNA ELFN1-AS1 promotes esophageal cancer progression by up-regulating GFPT1 via sponging miR-183-3p	32
Acute-phase protein synthesis: a key feature of innate immune functions of the liver	31
PINK1 and Parkin: team players in stress-induced mitophagy	31
Hsp70-mediated quality control: should I stay or should I go?	31
Metabolism of non-growing bacteria	31
The MICOS complex, a structural element of mitochondria with versatile functions	30
Human islet amyloid polypeptide (hIAPP) - a curse in type II diabetes mellitus: insights from structure and toxicity studies	30
Apoptosis inducing factor and mitochondrial NADH dehydrogenases: redox-controlled gear boxes to switch between mitochondrial biogenesis and cell death	29
How to get to the other side of the mitochondrial inner membrane – the protein import motor	29
Regulation of mitochondrial plasticity by the i-AAA protease YME1L	29
Glutaredoxins and iron-sulfur protein biogenesis at the interface of redox biology and iron metabolism	29
Thiol-based redox switches in the major pathogen Staphylococcus aureus	28
DASH-type cryptochromes – solved and open questions	28
Thiol switches in membrane proteins - Extracellular redox regulation in cell biology	28
The role of mitochondrial ATP synthase in cancer	28

The biogenesis of mitochondrial intermembrane space proteins	27
Unexpected metabolic versatility among type II methanotrophs in the Alphaproteobacteria	27
Citrate synthase desuccinylation by SIRT5 promotes colon cancer cell proliferation and migration	26
The role of very long chain fatty acids in yeast physiology and human diseases	26
Emerging roles for non-selenium containing ER-resident glutathione peroxidases in cell signaling and disease	25
The ups and downs of ectoine: structural enzymology of a major microbial stress protectant and versatile nutrient	24
New horizons in mitochondrial contact site research	23
Brothers in arms: proBDNF/BDNF and sAPPα/Aβ-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of Alzheimer’s disease	22
Multicellular and unicellular responses of microbial biofilms to stress	22
Myricetin protects pancreatic β-cells from human islet amyloid polypeptide (hIAPP) induced cytotoxicity and restores islet function	21
Redox-dependent and independent effects of thioredoxin interacting protein	21
Glutamine synthetase as a central element in hepatic glutamine and ammonia metabolism: novel aspects	20
RNA secondary structure dependence in METTL3–METTL14 mRNA methylation is modulated by the N-terminal domain of METTL3	20
A progesterone receptor membrane component 1 antagonist induces large vesicles independent of progesterone receptor membrane component 1 expression	19
Redox regulation in host-pathogen interactions: thiol switches and beyond	19
Biosynthesis and function of cell-surface polysaccharides in the social bacterium Myxococcus xanthus	19
Pathomechanisms in hepatic encephalopathy	18
Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins	18
ADAM8 affects glioblastoma progression by regulating osteopontin-mediated angiogenesis	17
Diversity of GPI-anchored fungal adhesins	17
Starting the engine of the powerhouse: mitochondrial transcription and beyond	16
Hsa-miR-186-5p regulates TGFβ signaling pathway through expression suppression of SMAD6 and SMAD7 genes in colorectal cancer	16
Chemerin – exploring a versatile adipokine	16
LOTUS-domain proteins - developmental effectors from a molecular perspective	16
Modular assembly of yeast mitochondrial ATP synthase and cytochrome oxidase	16
Protein import by the mitochondrial disulfide relay in higher eukaryotes	16
The endoplasmic reticulum-mitochondria encounter structure: coordinating lipid metabolism across membranes	15
Investigation of the structure of regulatory proteins interacting with glycosaminoglycans by combining NMR spectroscopy and molecular modeling – the beginning of a wonderful friendship	15
Proteostasis in thermogenesis and obesity	15
High-mobility group box 3 (HMGB3) silencing inhibits non-small cell lung cancer development through regulating Wnt/β-catenin pathway	14
Biochemical unity revisited: microbial central carbon metabolism holds new discoveries, multi-tasking pathways, and redundancies with a reason	14
iMLP, a predictor for internal matrix targeting-like sequences in mitochondrial proteins	14
The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes	14
Post-translational lysine ac(et)ylation in health, ageing and disease	14
Influence of monovalent metal ions on metal binding and catalytic activity of the 10–23 DNAzyme	14
Detecting myocardial scar using electrocardiogram data and deep neural networks	14
A guide to designing photocontrol in proteins: methods, strategies and applications	14
Revisiting the interaction of heme with hemopexin	13
Hepatic stellate cells: current state and open questions	13
Generating asymmetry in a changing environment: cell cycle regulation in dimorphic alphaproteobacteria	13
Porins as helpers in mitochondrial protein translocation	13
Cyclic di-GMP signaling controlling the free-living lifestyle of alpha-proteobacterial rhizobia	13
Collagen/glycosaminoglycan-based matrices for controlling skin cell responses	13
Regulation of RNA helicase activity: principles and examples	13
HDAC8 promotes daunorubicin resistance of human acute myeloid leukemia cells via regulation of IL-6 and IL-8	12
The structure of the TOM core complex in the mitochondrial outer membrane	12
New insights into the role of glycosaminoglycans in the endosteal bone microenvironment	12
Regulation of RNA stability at the 3′ end	12
Thioredoxin-dependent control balances the metabolic activities of tetrapyrrole biosynthesis	11
An RNA-centric view on gut Bacteroidetes	11

Mtr4 RNA helicase structures and interactions	11
Genomic insights into cyanobacterial protein translocation systems	11
Osteopontin enhances the migration of lung fibroblasts via upregulation of interleukin-6 through the extracellular signal-regulated kinase (ERK) pathway	11
Thiol-based switching mechanisms of stress-sensing chaperones	11
Dead or alive: DEAD-box ATPases as regulators of ribonucleoprotein complex condensation	11
Small-molecule modulation of p53 protein-protein interactions	10
Irisin ameliorates endoplasmic reticulum stress and liver fibrosis through inhibiting PERK-mediated destabilization of HNRNPA1 in hepatic stellate cells	10
Membrane damage and repair: a thin line between life and death	10
Improvement of wound healing by the development of ECM-inspired biomaterial coatings and controlled protein release	10
Redefining proteostasis transcription factors in organismal stress responses, development, metabolism, and health	10
Expansion and inflammation of white adipose tissue - focusing on adipocyte progenitors	10
TFAP2A-induced SLC2A1-AS1 promotes cancer cell proliferation	10
A primer on heme biosynthesis	10
The role of mycotoxins in neurodegenerative diseases: current state of the art and future perspectives of research	10
Structures and nucleic acid-binding preferences of the eukaryotic ARID domain	10
Genetically encoded thiol redox-sensors in the zebrafish model: lessons for embryonic development and regeneration	10
Small dense low-density lipoprotein-lowering agents	9
CERKL alleviates ischemia reperfusion-induced nervous system injury through modulating the SIRT1/PINK1/Parkin pathway and mitophagy induction	9
Physiology of guanosine-based second messenger signaling in Bacillus subtilis	9
Molecular mechanisms of vasculopathy and coagulopathy in COVID-19	9
Heme delivery to heme oxygenase-2 involves glyceraldehyde-3-phosphate dehydrogenase	9
Spatial organization enhances versatility and specificity in cyclic di-GMP signaling	9
Pseudomonas aeruginosa and Staphylococcus aureus virulence factors as biomarkers of infection	9
New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals	9
DDX41: a multifunctional DEAD-box protein involved in pre-mRNA splicing and innate immunity	9
Targeting spectrin redox switches to regulate the mechanoproperties of red blood cells	9
Chemically modified glycosaminoglycan derivatives as building blocks for biomaterial coatings and hydrogels	9
Emerging contributions of formyl peptide receptors to neurodegenerative diseases	9
STAT3 promotes peritoneal metastasis of gastric cancer by enhancing mesothelial-mesenchymal transition	8
Rational approaches towards inorganic and organometallic antibacterials	8
The paracaspase MALT1 in psoriasis	8
PCAT1 induced by transcription factor YY1 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-216a-3p to up-regulate oncogene BCL3	8
Characterization of a fluorescent 1,8-naphthalimide-functionalized PAMAM dendrimer and its Cu(ii) complexes as cytotoxic drugs: EPR and biological studies in myeloid tumor cells	8
Decreased level of miR-1301 promotes colorectal cancer progression via activation of STAT3 pathway	8
Placental mitochondrial function as a driver of angiogenesis and placental dysfunction	8
Structural insights into the modulation of PDGF/PDGFR-β complexation by hyaluronan derivatives	8
Individual and combined effects of GIP and xenin on differentiation, glucose uptake and lipolysis in 3T3-L1 adipocytes	8
Transcription, translation, and DNA repair: new insights from emerging noncanonical substrates of RNA helicases	8
Zinc-dependent changes in oxidative and endoplasmic reticulum stress during cardiomyocyte hypoxia/reoxygenation	8
Modulation of macrophage functions by ECM-inspired wound dressings – a promising therapeutic approach for chronic wounds	8
The piRNA pathway in planarian flatworms: new model, new insights	8
Identification of cytokeratin24 as a tumor suppressor for the management of head and neck cancer	8
Transfer RNA processing – from a structural and disease perspective	8
Epithelial-mesenchymal transition and H2O2 signaling – a driver of disease progression and a vulnerability in cancers	8
The role of host heme in bacterial infection	8
Comprehensive analysis of peptides and low molecular weight components of the giant ant Dinoponera quadriceps venom	8
Vorinostat exhibits anticancer effects in triple-negative breast cancer cells by preventing nitric oxide-driven histone deacetylation	7
Galectin-3 is modulated in pancreatic cancer cells under hypoxia and nutrient deprivation	7
Elucidating the anti-biofilm and anti-quorum sensing potential of selenocystine against respiratory tract infections causing bacteria: in vitro and in silico studies	7
Berberine improves dietary-induced cardiac remodeling by upregulating Kruppel-like factor 4-dependent mitochondrial function	7
Effect of myeloperoxidase oxidation and N-homocysteinylation of high-density lipoprotein on endothelial repair function	7
Machine learning based disease prediction from genotype data	7
Exceptionally versatile take II: post-translational modifications of lysine and their impact on bacterial physiology	7
The phytochemical plumbagin reciprocally modulates osteoblasts and osteoclasts	7
Role of the gut microbiota in airway immunity and host defense against respiratory infections	7
Histone deacetylase 1 regulates the malignancy of oral cancer cells via miR-154-5p/PCNA axis	7
Assessment of the breadth of binding promiscuity of heme towards human proteins	7
C-X-C chemokine receptor 2 (Cxcr2) promotes hepatocellular carcinoma immune evasion via regulating programmed death-ligand 1 (PD-L1)	6
Specific acclimations to phosphorus limitation in the marine diatom Phaeodactylum tricornutum	6
Apolipoprotein C-II and C-III preferably transfer to both high-density lipoprotein (HDL)2 and the larger HDL3 from very low-density lipoprotein (VLDL)	6
Characterization of the scavenger cell proteome in mouse and rat liver	6
Good things come to those who bait: the peroxisomal docking complex	6
High cellulose diet promotes intestinal motility through regulating intestinal immune homeostasis and serotonin biosynthesis	6
Long non-coding RNA FAM66C regulates glioma growth via the miRNA/LATS1 signaling pathway	6
The relevance of adhesion G protein-coupled receptors in metabolic functions	6
Astrocytic potassium and calcium channels as integrators of the inflammatory and ischemic CNS microenvironment	6
Molecular insights into endolysosomal microcompartment formation and maintenance	6
The role of the Na+/Ca2+-exchanger (NCX) in cancer-associated fibroblasts	6
Unification of functional annotation descriptions using text mining	6
JMJD3-regulated expression of IL-6 is involved in the proliferation and chemosensitivity of acute myeloid leukemia cells	6
M6A methylation-mediated elevation of SM22α inhibits the proliferation and migration of vascular smooth muscle cells and ameliorates intimal hyperplasia in type 2 diabetes mellitus	6
Role of vasodilation in liver regeneration and health	5
Drug development for neurodegenerative diseases	5
Tissue factor pathway inhibitor 2 is a potent kallikrein-related protease 12 inhibitor	5
Neuronal stress granules as dynamic microcompartments: current concepts and open questions	5
Glycation of benign meningioma cells leads to increased invasion	5
Structural insights into the repair mechanism of AGT for methyl-induced DNA damage	5
Trispecific antibodies produced from mAb2 pairs by controlled Fab-arm exchange	5
TRPM3 in the eye and in the nervous system – from new findings to novel mechanisms	5
A role of heparan sulphate proteoglycan in the cellular uptake of lipocalins ß-lactoglobulin and allergen Fel d 4	5

The antioxidant Rutin counteracts the pathological impact of α-synuclein on the enteric nervous system in vitro	5
Regulation of transforming growth factor-β1-stimulation of Runx2 acetylation for matrix metalloproteinase 13 expression in osteoblastic cells	5
The many facets of bile acids in the physiology and pathophysiology of the human liver	5
Identification of novel cardiovascular disease associated metabolites using untargeted metabolomics	5
Expanded profiling of β-lactam selectivity for penicillin-binding proteins in Streptococcus pneumoniae D39	5
Lefty A is involved in sunitinib resistance of renal cell carcinoma cells via regulation of IL-8	5
LncRNA-p21 suppresses cell proliferation and induces apoptosis in gastric cancer by sponging miR-514b-3p and up-regulating ARHGEF9 expression	5
The DHX36-specific-motif (DSM) enhances specificity by accelerating recruitment of DNA G-quadruplex structures	5
Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators	5
Rapid metabolic and bioenergetic adaptations of astrocytes under hyperammonemia – a novel perspective on hepatic encephalopathy	5
Integrated Ca2+ flux and AFM force analysis in human iPSC-derived cardiomyocytes	5
Historic nucleic acids isolated by Friedrich Miescher contain RNA besides DNA	5
Nuclear redox processes in land plant development and stress adaptation	5
Nitazoxanide inhibits osteosarcoma cells growth and metastasis by suppressing AKT/mTOR and Wnt/β-catenin signaling pathways	5
Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies	5
Infection, inflammation and thrombosis: a review of potential mechanisms mediating arterial thrombosis associated with influenza and severe acute respiratory syndrome coronavirus 2	5
Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry	5
Artificial metalloenzymes in a nutshell: the quartet for efficient catalysis	5
Lysine acetyltransferase Tip60 acetylates the APP adaptor Fe65 to increase its transcriptional activity	4
Membrane-anchored substrate binding proteins are deployed in secondary TAXI transporters	4
Arrestin-dependent internalization of rhodopsin-like G protein-coupled receptors	4
The impact of oxytocin on thiol/disulphide and malonyldialdehyde/glutathione homeostasis in stressed rats	4
Dynamics of the translocation pore of the human peroxisomal protein import machinery	4
In vitro osteogenic activities of sulfated derivative of polysaccharide extracted from Tamarindus indica L.	4
Core 1 O-N-acetylgalactosamine (O-GalNAc) glycosylation in the human cell nucleus	4
Eukaryotic tRNA splicing – one goal, two strategies, many players	4
Modular peptide binders – development of a predictive technology as alternative for reagent antibodies	4
Two are not enough: synthetic strategies and applications of unnatural base pairs	4
Prediction and analysis of redox-sensitive cysteines using machine learning and statistical methods	4
Morphological dependent effect of cell-free formed supramolecular fibronectin on cellular activities	4
The cAMP responsive element modulator (CREM) is a regulator of CD4+ T cell function	4
A biochemical view on the septins, a less known component of the cytoskeleton	4
Altered population activity and local tuning heterogeneity in auditory cortex of Cacna2d3-deficient mice	4
Loss of respiratory complex I subunit NDUFB10 affects complex I assembly and supercomplex formation	4
Tumor cell lysis and synergistically enhanced antibody-dependent cell-mediated cytotoxicity by NKG2D engagement with a bispecific immunoligand targeting the HER2 antigen	4
Human RecQ helicases in transcription-associated stress management: bridging the gap between DNA and RNA metabolism	4
Carotenoids in Sporidiobolus pararoseus ameliorate diabetic nephropathy in mice through attenuating oxidative stress	4
A novel NMDA receptor test model based on hiPSC-derived neural cells	4
LINC00520 up-regulates SOX5 to promote cell proliferation and invasion by miR-4516 in human hepatocellular carcinoma	4
The extracellular region of bovine milk butyrophilin exhibits closer structural similarity to human myelin oligodendrocyte glycoprotein than to immunological BTN family receptors	4
Tuning the network charge of biohybrid hydrogel matrices to modulate the release of SDF-1	4
Illuminating the brain-genetically encoded single wavelength fluorescent biosensors to unravel neurotransmitter dynamics	3
Men who stare at bone: multimodal monitoring of bone healing	3
Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABAAR density	3
How to draw the line – Raman spectroscopy as a tool for the assessment of biomedicines	3
Insights into structure, affinity, specificity, and function of GAG-protein interactions through the chemoenzymatic preparation of defined sulfated oligohyaluronans	3
Epitranscriptomic modifications in acute myeloid leukemia: m6A and 2′-O-methylation as targets for novel therapeutic strategies	3
L-theanine induces skeletal muscle fiber type transformation by activation of prox1/CaN signaling pathway in C2C12 myotubes	3
Fibrillar biopolymer-based scaffolds to study macrophage-fibroblast crosstalk in wound repair	3
TMPRSS13 zymogen activation, surface localization, and shedding is regulated by proteolytic cleavage within the non-catalytic stem region	3
Distinct conformational and energetic features define the specific recognition of (di)aromatic peptide motifs by PEX14	3
Heat shock protein 60 is a disease-associated sialoglycoprotein in human non-small cell lung cancer	3
Phage-display reveals interaction of lipocalin allergen Can f 1 with a peptide resembling the antigen binding region of a human γδT-cell receptor	3
Interaction of nucleoporins with nuclear transport receptors: a structural perspective	3
IL-24 inhibits the malignancy of human glioblastoma cells via destabilization of Zeb1	3
Insights on intermolecular FMN-heme domain interaction and the role of linker length in cytochrome P450cin fusion proteins	3
Dihydroartemisinin ameliorates balloon injury-induced neointimal formation through suppressing autophagy in vascular smooth muscle cells	3
Autophagic and non-autophagic functions of the Saccharomyces cerevisiae PROPPINs Atg18, Atg21 and Hsv2	3
The readily retrievable pool of synaptic vesicles	3
Vemurafenib downmodulates aggressiveness mediators of colorectal cancer (CRC): Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP), Protein Tyrosine Phosphatase 1B (PTP1B) and Transforming Grow	3
Bayesian methods in integrative structure modeling	3
Membrane binding and pore forming insertion of PEX5 into horizontal lipid bilayer	3
Anti-amyloidogenic effect of artemin on α-synuclein	3
Determination of free heme in stored red blood cells with an apo-horseradish peroxidase-based assay	3
The role of ADAM17 during liver damage	3
MicroRNA-6838-5p suppresses the self-renewal and metastasis of human liver cancer stem cells through downregulating CBX4 expression and inactivating ERK signaling	3
Functional genomics meta-analysis to identify gene set enrichment networks in cardiac hypertrophy	3
Direct comparison of the immunogenicity of major histocompatibility complex-I and -II deficient mesenchymal stem cells in vivo	3
Detection of follicular regions in actin-stained whole slide images of the human lymph node by shock filter	3
Influence of phosphorylation on intermediate filaments	3
Signal transduction mechanisms in heme-based globin-coupled oxygen sensors with a focus on a histidine kinase (AfGcHK) and a diguanylate cyclase (YddV or EcDosC)	3
Interactions of Na+/taurocholate cotransporting polypeptide with host cellular proteins upon hepatitis B and D virus infection: novel potential targets for antiviral therapy	3
M2 macrophages-derived exosomal miR-3917 promotes the progression of lung cancer via targeting GRK6	3