International Journal of Molecular Sciences

(The median citation count of International Journal of Molecular Sciences is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
Pathophysiology of Type 2 Diabetes Mellitus1024
Mechanisms of Multidrug Resistance in Cancer Chemotherapy819
The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies750
NRF2, a Transcription Factor for Stress Response and Beyond659
Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies643
The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases621
Analytical Methods Used in Determining Antioxidant Activity: A Review609
Macrophage Polarization States in the Tumor Microenvironment574
The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics524
Silver Nanoparticles and Their Antibacterial Applications524
Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives472
Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms465 A Web Tool for the Comparison of Gene Expression in Normal, Tumor and Metastatic Tissues429
Metabolic Syndrome: Updates on Pathophysiology and Management in 2021407
Nutritional Indices for Assessing Fatty Acids: A Mini-Review393
Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism386
Regulation of Plant Responses to Salt Stress383
Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer352
Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020342
Pseudomonas aeruginosa Biofilms338
A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?330
PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects306
The MTT Assay: Utility, Limitations, Pitfalls, and Interpretation in Bulk and Single-Cell Analysis301
Neuroinflammatory Mechanisms in Ischemic Stroke: Focus on Cardioembolic Stroke, Background, and Therapeutic Approaches296
ROS Homeostasis in Abiotic Stress Tolerance in Plants293
The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling289
COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 C271
The Flavonoid Biosynthesis Network in Plants270
Fabrication and Applications of Microfluidic Devices: A Review260
Current and Future Development in Lung Cancer Diagnosis251
Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors246
Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis242
Transport of Extracellular Vesicles across the Blood-Brain Barrier: Brain Pharmacokinetics and Effects of Inflammation241
A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides240
Pathophysiology of Atherosclerosis229
Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases220
Functional Relationship between Osteogenesis and Angiogenesis in Tissue Regeneration216
Seafood Waste as Attractive Source of Chitin and Chitosan Production and Their Applications215
Regulation of ROS Metabolism in Plants under Environmental Stress: A Review of Recent Experimental Evidence213
Silk Fibroin as a Functional Biomaterial for Tissue Engineering210
Cytochrome P450 Enzymes and Drug Metabolism in Humans210
Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis210
Ferroptosis Mechanisms Involved in Neurodegenerative Diseases209
The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target207
Regulation of Reactive Oxygen Species and Antioxidant Defense in Plants under Salinity207
Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications206
Safe Nanoparticles: Are We There Yet?204
Chronic Low Grade Inflammation in Pathogenesis of PCOS203
Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis199
Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease199
Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases196
An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases196
Cinnamic Acid Derivatives and Their Biological Efficacy193
Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress192
Neuroprotective Effect of Antioxidants in the Brain192
Ferroptosis in Liver Diseases: An Overview191
Roles of Autophagy in Oxidative Stress190
An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities188
Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis188
Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update188
Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review188
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4187
Multiple Functions of MYB Transcription Factors in Abiotic Stress Responses185
CRISPR-Cas9 DNA Base-Editing and Prime-Editing184
The Immune Functions of Keratinocytes in Skin Wound Healing183
Advances in Chitosan-Based Nanoparticles for Drug Delivery181
Terpenes and Terpenoids in Plants: Interactions with Environment and Insects181
Ionic Liquids Toxicity—Benefits and Threats179
Lactic Acid and an Acidic Tumor Microenvironment suppress Anticancer Immunity179
Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2179
Role of Cadherins in Cancer—A Review178
mRNA Vaccine Era—Mechanisms, Drug Platform and Clinical Prospection173
Function and Mechanism of Jasmonic Acid in Plant Responses to Abiotic and Biotic Stresses172
Spheroids as a Type of Three-Dimensional Cell Cultures—Examples of Methods of Preparation and the Most Important Application171
Inflammation-Related Biomarkers for the Prediction of Prognosis in Colorectal Cancer Patients171
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands171
Essential Oils as Antiviral Agents, Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation171
Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption171
Oxidative Stress, Plant Natural Antioxidants, and Obesity170
Neurodegeneration and Inflammation—An Interesting Interplay in Parkinson’s Disease170
Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee168
Rhizosphere Bacteria in Plant Growth Promotion, Biocontrol, and Bioremediation of Contaminated Sites: A Comprehensive Review of Effects and Mechanisms168
Plant Responses to Heat Stress: Physiology, Transcription, Noncoding RNAs, and Epigenetics167
Biological Properties and Prospects for the Application of Eugenol—A Review167
MYB-Mediated Regulation of Anthocyanin Biosynthesis167
Chitosan and Cellulose-Based Hydrogels for Wound Management165
Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches165
Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases163
Peripheral Nerve Regeneration and Muscle Reinnervation163
Liquid–Liquid Phase Separation in Crowded Environments162
3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages162
Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements161
Focus on the Role of NLRP3 Inflammasome in Diseases161
Molecular Mechanisms of Atopic Dermatitis Pathogenesis160
Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance159
Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways157
Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers157
Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action156
Monoterpenes and Their Derivatives—Recent Development in Biological and Medical Applications155
A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics154
Investigation of Some Antiviral N-Heterocycles as COVID 19 Drug: Molecular Docking and DFT Calculations154
On Iron Metabolism and Its Regulation154
Trichoderma: The Current Status of Its Application in Agriculture for the Biocontrol of Fungal Phytopathogens and Stimulation of Plant Growth153
CD4 T Helper Cell Subsets and Related Human Immunological Disorders153
Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease153
Tryptophan Metabolism and Gut-Brain Homeostasis152
Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities152
Regulation of Osteoblast Differentiation by Cytokine Networks151
Targeting Molecular Mechanisms Underlying Treatment Efficacy and Resistance in Osteosarcoma: A Review of Current and Future Strategies151
Gut Microbiota and Intestinal Trans-Epithelial Permeability151
Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials151
Cell Death in Liver Diseases: A Review150
Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle150
Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE(-/-) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis150
Glutathione in the Brain149
Factors Influencing the Antibacterial Activity of Chitosan and Chitosan Modified by Functionalization149
Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer148
The Significance of Mitochondrial Dysfunction in Cancer148
Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis148
Endometrial Decidualization: The Primary Driver of Pregnancy Health148
Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction148
Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds147
Autophagy and Autophagy-Related Diseases: A Review147
Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis147
Cytokine Networks in the Pathogenesis of Rheumatoid Arthritis146
Anti-Angiogenic Therapy: Current Challenges and Future Perspectives146
Exosomes in Angiogenesis and Anti-angiogenic Therapy in Cancers146
Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity144
Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy144
MicroRNA-Based Diagnosis and Therapy144
Role of Insulin Resistance in MAFLD143
Advances in De Novo Drug Design: From Conventional to Machine Learning Methods143
Inflammatory Response Mechanisms of the Dentine–Pulp Complex and the Periapical Tissues142
Recent Updates of Transarterial Chemoembolilzation in Hepatocellular Carcinoma141
Interaction of Intestinal Bacteria with Human Rotavirus during Infection in Children141
Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity140
Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies138
Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications138
Plant Secondary Metabolites as Defense Tools against Herbivores for Sustainable Crop Protection138
Use of H2O2 to Cause Oxidative Stress, the Catalase Issue137
FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy137
Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression137
An Update on Vitamin D Metabolism137
Interactions of Gold and Silver Nanoparticles with Bacterial Biofilms: Molecular Interactions behind Inhibition and Resistance137
Ovarian Cancer Immunotherapy and Personalized Medicine136
Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences136
MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology135
Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue134
The Immune Microenvironment in Pancreatic Cancer133
Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action133
EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration133
Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)132
Mitochondria Targeting as an Effective Strategy for Cancer Therapy132
Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure132
Role of Leptin in Inflammation and Vice Versa131
The History and Mystery of Alveolar Epithelial Type II Cells: Focus on Their Physiologic and Pathologic Role in Lung131
Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions130
The Role of the Epididymis and the Contribution of Epididymosomes to Mammalian Reproduction130
Bone Microenvironment and Osteosarcoma Metastasis130
Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration130
Copper Dyshomeostasis in Neurodegenerative Diseases—Therapeutic Implications130
Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes130
The Role of mTOR Signaling as a Therapeutic Target in Cancer129
New Treatment Addressing the Pathogenesis of Psoriasis129
The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease129
Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis128
Anti-Obesity Effects of Polyphenol Intake: Current Status and Future Possibilities128
The CCL20-CCR6 Axis in Cancer Progression127
The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway126
Molecular Mechanisms and Emerging Therapeutics for Osteoporosis126
Mechanisms and Regulation of Cellular Senescence125
The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes125
Osteoporosis Due to Hormone Imbalance: An Overview of the Effects of Estrogen Deficiency and Glucocorticoid Overuse on Bone Turnover124
Mechanisms of Abscisic Acid-Mediated Drought Stress Responses in Plants124
PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects124
VEGF-A in Cardiomyocytes and Heart Diseases124
Natural Killer Cell Dysfunction and Its Role in COVID-19124
Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-κB Activation: A Review of the Molecular Mechanisms124
Seed Priming: A Feasible Strategy to Enhance Drought Tolerance in Crop Plants124
Defining Dry Eye from a Clinical Perspective123
The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy123
Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target123
WNT Signaling in Melanoma123
Biomarkers in Colorectal Cancer: Current Research and Future Prospects123
Fatty Acid Diets: Regulation of Gut Microbiota Composition and Obesity and Its Related Metabolic Dysbiosis122
Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process122
Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials122
Prediction of Novel Inhibitors of the Main Protease (M-pro) of SARS-CoV-2 through Consensus Docking and Drug Reposition121
Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders121
Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells120
Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials120
An Overview of the Main Genetic, Epigenetic and Environmental Factors Involved in Autism Spectrum Disorder Focusing on Synaptic Activity120
Tumor-Associated Macrophages in Osteosarcoma: From Mechanisms to Therapy119
Small Molecule NF-κB Pathway Inhibitors in Clinic119
Role of Insulin in Health and Disease: An Update119
Mechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injury119
The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease118
The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors—A Review of Literature118
Circulating Cell-Free Nucleic Acids: Main Characteristics and Clinical Application118
Neutrophil Extracellular Traps and Their Implications in Cardiovascular and Inflammatory Disease118
The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment118
Endothelial Damage in Acute Respiratory Distress Syndrome118
The Multifunctional Roles of Polyphenols in Plant-Herbivore Interactions118
The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications118
Gestational Diabetes Mellitus: A Harbinger of the Vicious Cycle of Diabetes117
Prognostic and Predictive Biomarkers in Gliomas117
The Plants of the Asteraceae Family as Agents in the Protection of Human Health117
Genetic Markers in Lung Cancer Diagnosis: A Review116
Synthesis, Properties, and Biological Applications of Metallic Alloy Nanoparticles116
Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects116
Antimicrobial Peptides: An Update on Classifications and Databases116
Advances in Lipid Extraction Methods—A Review116
Treg Enhancing Therapies to Treat Autoimmune Diseases116
Induction of Adipose Tissue Browning as a Strategy to Combat Obesity115
Diabetes during Pregnancy: A Maternal Disease Complicating the Course of Pregnancy with Long-Term Deleterious Effects on the Offspring. A Clinical Review115
LncRNAs in Ovarian Cancer Progression, Metastasis, and Main Pathways: ceRNA and Alternative Mechanisms115
Legacy and Emerging Per- and Polyfluoroalkyl Substances: Analytical Techniques, Environmental Fate, and Health Effects114
Biological Properties, Bioactive Constituents, and Pharmacokinetics of Some Capsicum spp. and Capsaicinoids114
SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19114
Differential Therapeutic Effect of Extracellular Vesicles Derived by Bone Marrow and Adipose Mesenchymal Stem Cells on Wound Healing of Diabetic Ulcers and Correlation to Their Cargoes114
Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis113
Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms113
Irinotecan—Still an Important Player in Cancer Chemotherapy: A Comprehensive Overview113
Contribution of Exogenous Proline to Abiotic Stresses Tolerance in Plants: A Review113
Effect of Physico-Chemical Properties of Nanoparticles on Their Intracellular Uptake113
Novel CRISPR–Cas Systems: An Updated Review of the Current Achievements, Applications, and Future Research Perspectives113
Sequence, Chromatin and Evolution of Satellite DNA112
Liquid–Liquid Phase Separation by Intrinsically Disordered Protein Regions of Viruses: Roles in Viral Life Cycle and Control of Virus–Host Interactions112
Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?112
Polycyclic Aromatic Hydrocarbons in Foods: Biological Effects, Legislation, Occurrence, Analytical Methods, and Strategies to Reduce Their Formation111
Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases111
Strategies for Bone Regeneration: From Graft to Tissue Engineering111
Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections111
Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery111
Selectivity of Transport Processes in Ion-Exchange Membranes: Relationship with the Structure and Methods for Its Improvement110
Molecular Mechanisms of Treatment Resistance in Glioblastoma110
Mitochondria as a Cellular Hub in Infection and Inflammation109
Methods Favoring Homology-Directed Repair Choice in Response to CRISPR/Cas9 Induced-Double Strand Breaks109
Monounsaturated Fatty Acids in Obesity-Related Inflammation109
Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging109
Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis109
Epigenetics of Aging and Aging-Associated Diseases109
ROS in Platelet Biology: Functional Aspects and Methodological Insights108
Benzo[a]pyrene—Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity108
Combination Drug Therapy for the Management of Alzheimer’s Disease108
Can SARS-CoV-2 Virus Use Multiple Receptors to Enter Host Cells?108
Putative Origins of Cell-Free DNA in Humans: A Review of Active and Passive Nucleic Acid Release Mechanisms107
A Comprehensive Review: Sphingolipid Metabolism and Implications of Disruption in Sphingolipid Homeostasis107
AMPK, Mitochondrial Function, and Cardiovascular Disease107
Secretory IgA in Intestinal Mucosal Secretions as an Adaptive Barrier against Microbial Cells107