International Journal of Molecular Sciences

(The H4-Index of International Journal of Molecular Sciences is 138. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
Pathophysiology of Type 2 Diabetes Mellitus1024
Mechanisms of Multidrug Resistance in Cancer Chemotherapy819
The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies750
NRF2, a Transcription Factor for Stress Response and Beyond659
Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies643
The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases621
Analytical Methods Used in Determining Antioxidant Activity: A Review609
Macrophage Polarization States in the Tumor Microenvironment574
Silver Nanoparticles and Their Antibacterial Applications524
The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics524
Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives472
Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms465 A Web Tool for the Comparison of Gene Expression in Normal, Tumor and Metastatic Tissues429
Metabolic Syndrome: Updates on Pathophysiology and Management in 2021407
Nutritional Indices for Assessing Fatty Acids: A Mini-Review393
Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism386
Regulation of Plant Responses to Salt Stress383
Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer352
Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020342
Pseudomonas aeruginosa Biofilms338
A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?330
PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects306
The MTT Assay: Utility, Limitations, Pitfalls, and Interpretation in Bulk and Single-Cell Analysis301
Neuroinflammatory Mechanisms in Ischemic Stroke: Focus on Cardioembolic Stroke, Background, and Therapeutic Approaches296
ROS Homeostasis in Abiotic Stress Tolerance in Plants293
The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling289
COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 C271
The Flavonoid Biosynthesis Network in Plants270
Fabrication and Applications of Microfluidic Devices: A Review260
Current and Future Development in Lung Cancer Diagnosis251
Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors246
Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis242
Transport of Extracellular Vesicles across the Blood-Brain Barrier: Brain Pharmacokinetics and Effects of Inflammation241
A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides240
Pathophysiology of Atherosclerosis229
Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases220
Functional Relationship between Osteogenesis and Angiogenesis in Tissue Regeneration216
Seafood Waste as Attractive Source of Chitin and Chitosan Production and Their Applications215
Regulation of ROS Metabolism in Plants under Environmental Stress: A Review of Recent Experimental Evidence213
Cytochrome P450 Enzymes and Drug Metabolism in Humans210
Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis210
Silk Fibroin as a Functional Biomaterial for Tissue Engineering210
Ferroptosis Mechanisms Involved in Neurodegenerative Diseases209
Regulation of Reactive Oxygen Species and Antioxidant Defense in Plants under Salinity207
The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target207
Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications206
Safe Nanoparticles: Are We There Yet?204
Chronic Low Grade Inflammation in Pathogenesis of PCOS203
Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease199
Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis199
Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases196
An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases196
Cinnamic Acid Derivatives and Their Biological Efficacy193
Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress192
Neuroprotective Effect of Antioxidants in the Brain192
Ferroptosis in Liver Diseases: An Overview191
Roles of Autophagy in Oxidative Stress190
An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities188
Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis188
Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update188
Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review188
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4187
Multiple Functions of MYB Transcription Factors in Abiotic Stress Responses185
CRISPR-Cas9 DNA Base-Editing and Prime-Editing184
The Immune Functions of Keratinocytes in Skin Wound Healing183
Terpenes and Terpenoids in Plants: Interactions with Environment and Insects181
Advances in Chitosan-Based Nanoparticles for Drug Delivery181
Lactic Acid and an Acidic Tumor Microenvironment suppress Anticancer Immunity179
Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2179
Ionic Liquids Toxicity—Benefits and Threats179
Role of Cadherins in Cancer—A Review178
mRNA Vaccine Era—Mechanisms, Drug Platform and Clinical Prospection173
Function and Mechanism of Jasmonic Acid in Plant Responses to Abiotic and Biotic Stresses172
Inflammation-Related Biomarkers for the Prediction of Prognosis in Colorectal Cancer Patients171
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands171
Essential Oils as Antiviral Agents, Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation171
Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption171
Spheroids as a Type of Three-Dimensional Cell Cultures—Examples of Methods of Preparation and the Most Important Application171
Neurodegeneration and Inflammation—An Interesting Interplay in Parkinson’s Disease170
Oxidative Stress, Plant Natural Antioxidants, and Obesity170
Rhizosphere Bacteria in Plant Growth Promotion, Biocontrol, and Bioremediation of Contaminated Sites: A Comprehensive Review of Effects and Mechanisms168
Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee168
Biological Properties and Prospects for the Application of Eugenol—A Review167
MYB-Mediated Regulation of Anthocyanin Biosynthesis167
Plant Responses to Heat Stress: Physiology, Transcription, Noncoding RNAs, and Epigenetics167
Chitosan and Cellulose-Based Hydrogels for Wound Management165
Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches165
Peripheral Nerve Regeneration and Muscle Reinnervation163
Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases163
Liquid–Liquid Phase Separation in Crowded Environments162
3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages162
Focus on the Role of NLRP3 Inflammasome in Diseases161
Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements161
Molecular Mechanisms of Atopic Dermatitis Pathogenesis160
Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance159
Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways157
Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers157
Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action156
Monoterpenes and Their Derivatives—Recent Development in Biological and Medical Applications155
A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics154
Investigation of Some Antiviral N-Heterocycles as COVID 19 Drug: Molecular Docking and DFT Calculations154
On Iron Metabolism and Its Regulation154
Trichoderma: The Current Status of Its Application in Agriculture for the Biocontrol of Fungal Phytopathogens and Stimulation of Plant Growth153
CD4 T Helper Cell Subsets and Related Human Immunological Disorders153
Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease153
Tryptophan Metabolism and Gut-Brain Homeostasis152
Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities152
Regulation of Osteoblast Differentiation by Cytokine Networks151
Targeting Molecular Mechanisms Underlying Treatment Efficacy and Resistance in Osteosarcoma: A Review of Current and Future Strategies151
Gut Microbiota and Intestinal Trans-Epithelial Permeability151
Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials151
Cell Death in Liver Diseases: A Review150
Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle150
Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE(-/-) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis150
Glutathione in the Brain149
Factors Influencing the Antibacterial Activity of Chitosan and Chitosan Modified by Functionalization149
Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis148
Endometrial Decidualization: The Primary Driver of Pregnancy Health148
Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction148
Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer148
The Significance of Mitochondrial Dysfunction in Cancer148
Autophagy and Autophagy-Related Diseases: A Review147
Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis147
Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds147
Anti-Angiogenic Therapy: Current Challenges and Future Perspectives146
Exosomes in Angiogenesis and Anti-angiogenic Therapy in Cancers146
Cytokine Networks in the Pathogenesis of Rheumatoid Arthritis146
Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity144
Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy144
MicroRNA-Based Diagnosis and Therapy144
Role of Insulin Resistance in MAFLD143
Advances in De Novo Drug Design: From Conventional to Machine Learning Methods143
Inflammatory Response Mechanisms of the Dentine–Pulp Complex and the Periapical Tissues142
Recent Updates of Transarterial Chemoembolilzation in Hepatocellular Carcinoma141
Interaction of Intestinal Bacteria with Human Rotavirus during Infection in Children141
Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity140
Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies138
Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications138
Plant Secondary Metabolites as Defense Tools against Herbivores for Sustainable Crop Protection138