International Journal of Molecular Sciences

Papers
(The H4-Index of International Journal of Molecular Sciences is 141. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)
ArticleCitations
The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies1016
Analytical Methods Used in Determining Antioxidant Activity: A Review798
The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases779
Macrophage Polarization States in the Tumor Microenvironment730
Silver Nanoparticles and Their Antibacterial Applications720
The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics688
Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives585
Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms573
Metabolic Syndrome: Updates on Pathophysiology and Management in 2021537
TNMplot.com: A Web Tool for the Comparison of Gene Expression in Normal, Tumor and Metastatic Tissues513
Regulation of Plant Responses to Salt Stress465
Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer434
The MTT Assay: Utility, Limitations, Pitfalls, and Interpretation in Bulk and Single-Cell Analysis415
Pseudomonas aeruginosa Biofilms402
PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects391
Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020388
The Flavonoid Biosynthesis Network in Plants359
Current and Future Development in Lung Cancer Diagnosis350
Cytochrome P450 Enzymes and Drug Metabolism in Humans339
Fabrication and Applications of Microfluidic Devices: A Review335
Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis335
Pathophysiology of Atherosclerosis321
Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases318
An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases300
Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors300
Regulation of Reactive Oxygen Species and Antioxidant Defense in Plants under Salinity286
Safe Nanoparticles: Are We There Yet?269
A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics263
Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis261
Regulation of ROS Metabolism in Plants under Environmental Stress: A Review of Recent Experimental Evidence260
Silk Fibroin as a Functional Biomaterial for Tissue Engineering252
Chronic Low Grade Inflammation in Pathogenesis of PCOS248
Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis248
Ferroptosis Mechanisms Involved in Neurodegenerative Diseases248
Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update246
Function and Mechanism of Jasmonic Acid in Plant Responses to Abiotic and Biotic Stresses241
Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases239
Multiple Functions of MYB Transcription Factors in Abiotic Stress Responses238
The Immune Functions of Keratinocytes in Skin Wound Healing233
Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee230
Advances in Chitosan-Based Nanoparticles for Drug Delivery230
Rhizosphere Bacteria in Plant Growth Promotion, Biocontrol, and Bioremediation of Contaminated Sites: A Comprehensive Review of Effects and Mechanisms227
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4227
MicroRNA-Based Diagnosis and Therapy225
Terpenes and Terpenoids in Plants: Interactions with Environment and Insects222
Factors Influencing the Antibacterial Activity of Chitosan and Chitosan Modified by Functionalization222
Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action220
3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages216
Molecular Mechanisms of Atopic Dermatitis Pathogenesis216
Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review215
Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches215
Biological Properties and Prospects for the Application of Eugenol—A Review215
Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease210
Plant Secondary Metabolites as Defense Tools against Herbivores for Sustainable Crop Protection209
Trichoderma: The Current Status of Its Application in Agriculture for the Biocontrol of Fungal Phytopathogens and Stimulation of Plant Growth208
Inflammation-Related Biomarkers for the Prediction of Prognosis in Colorectal Cancer Patients207
Plant Responses to Heat Stress: Physiology, Transcription, Noncoding RNAs, and Epigenetics207
Cytokine Networks in the Pathogenesis of Rheumatoid Arthritis206
Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities204
Tryptophan Metabolism and Gut-Brain Homeostasis204
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands202
Oxidative Stress, Plant Natural Antioxidants, and Obesity201
MYB-Mediated Regulation of Anthocyanin Biosynthesis200
Lactic Acid and an Acidic Tumor Microenvironment suppress Anticancer Immunity199
Chitosan and Cellulose-Based Hydrogels for Wound Management197
Neurodegeneration and Inflammation—An Interesting Interplay in Parkinson’s Disease197
Role of Cadherins in Cancer—A Review196
On Iron Metabolism and Its Regulation195
Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies191
Peripheral Nerve Regeneration and Muscle Reinnervation190
Regulation of Osteoblast Differentiation by Cytokine Networks189
Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements189
CD4 T Helper Cell Subsets and Related Human Immunological Disorders188
Role of Insulin Resistance in MAFLD187
Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis186
Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials185
Glutathione in the Brain185
Osteoporosis Due to Hormone Imbalance: An Overview of the Effects of Estrogen Deficiency and Glucocorticoid Overuse on Bone Turnover184
Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2184
Anti-Angiogenic Therapy: Current Challenges and Future Perspectives181
Use of H2O2 to Cause Oxidative Stress, the Catalase Issue180
Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target180
Inflammatory Response Mechanisms of the Dentine–Pulp Complex and the Periapical Tissues179
Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression179
Ovarian Cancer Immunotherapy and Personalized Medicine177
Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction177
Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle176
Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)175
Autophagy and Autophagy-Related Diseases: A Review175
Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis175
Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer175
Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE(-/-) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis174
Advances in De Novo Drug Design: From Conventional to Machine Learning Methods173
Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells171
Mechanisms of Abscisic Acid-Mediated Drought Stress Responses in Plants170
Cell Death in Liver Diseases: A Review170
Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-κB Activation: A Review of the Molecular Mechanisms167
Recent Updates of Transarterial Chemoembolilzation in Hepatocellular Carcinoma165
Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences165
Interaction of Intestinal Bacteria with Human Rotavirus during Infection in Children162
The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy162
Role of Insulin in Health and Disease: An Update161
Copper Dyshomeostasis in Neurodegenerative Diseases—Therapeutic Implications161
Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process160
Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions159
Interactions of Gold and Silver Nanoparticles with Bacterial Biofilms: Molecular Interactions behind Inhibition and Resistance159
Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action158
Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity158
Advances in Lipid Extraction Methods—A Review158
New Treatment Addressing the Pathogenesis of Psoriasis158
The Immune Microenvironment in Pancreatic Cancer157
Benzo[a]pyrene—Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity156
Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis156
Mechanisms and Regulation of Cellular Senescence155
SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19155
Contribution of Exogenous Proline to Abiotic Stresses Tolerance in Plants: A Review155
The Role of Inflammation in Cardiovascular Disease155
Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue152
Seed Priming: A Feasible Strategy to Enhance Drought Tolerance in Crop Plants152
The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes152
The Apoptosis Paradox in Cancer150
Molecular Mechanisms and Emerging Therapeutics for Osteoporosis150
Mitochondria as a Cellular Hub in Infection and Inflammation150
Antimicrobial Peptides: An Update on Classifications and Databases150
Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases149
Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing149
Legacy and Emerging Per- and Polyfluoroalkyl Substances: Analytical Techniques, Environmental Fate, and Health Effects149
Prognostic and Predictive Biomarkers in Gliomas148
The Role of mTOR Signaling as a Therapeutic Target in Cancer147
Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials147
Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?147
Interaction between Lipopolysaccharide and Gut Microbiota in Inflammatory Bowel Diseases146
The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment145
The History and Mystery of Alveolar Epithelial Type II Cells: Focus on Their Physiologic and Pathologic Role in Lung145
The Curious Case of the HepG2 Cell Line: 40 Years of Expertise144
Defining Dry Eye from a Clinical Perspective144
PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects144
The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway144
Strategies for Bone Regeneration: From Graft to Tissue Engineering143
ICE-CBF-COR Signaling Cascade and Its Regulation in Plants Responding to Cold Stress142
The Plants of the Asteraceae Family as Agents in the Protection of Human Health141
The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease141
Effect of Physico-Chemical Properties of Nanoparticles on Their Intracellular Uptake141
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