Cellular and Molecular Life Sciences

Article	Citations
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling	678
Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics	206
Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis	194
Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance	138
The complement system in age-related macular degeneration	132
Arginine-dependent immune responses	130
Type I interferon-mediated tumor immunity and its role in immunotherapy	127
Mitophagy in tumorigenesis and metastasis	124
The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass	123
Alzheimer’s pathogenic mechanisms and underlying sex difference	112
The role of bile acids in carcinogenesis	107
The lysosome as an imperative regulator of autophagy and cell death	99
Histone acetylation dynamics regulating plant development and stress responses	99
Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders	97
Ins and outs of AlphaFold2 transmembrane protein structure predictions	88
The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice	84
Mettl14 mediates the inflammatory response of macrophages in atherosclerosis through the NF-κB/IL-6 signaling pathway	82
Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges	81
The enteric nervous system in gastrointestinal disease etiology	74
Mitochondrial quality control: from molecule to organelle	74
The regulatory roles of p53 in cardiovascular health and disease	73
Termite evolution: mutualistic associations, key innovations, and the rise of Termitidae	70
Recent progress in mass spectrometry-based strategies for elucidating protein–protein interactions	69
G-quadruplex DNA: a novel target for drug design	68
An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis	68

Autophagy and apoptosis cascade: which is more prominent in neuronal death?	68
Insulin granule biogenesis and exocytosis	67
The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons	66
The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective	66
Age-associated B cells in autoimmune diseases	66
Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives	65
Immune cells lacking Y chromosome show dysregulation of autosomal gene expression	63
PDGF receptor mutations in human diseases	63
Genome-wide association studies: assessing trait characteristics in model and crop plants	62
Ultrastructural modifications induced by SARS-CoV-2 in Vero cells: a kinetic analysis of viral factory formation, viral particle morphogenesis and virion release	61
Electrophysiology of ionotropic GABA receptors	59
Mechanisms of fungal dissemination	59
METTL3 promotes oxaliplatin resistance of gastric cancer CD133+ stem cells by promoting PARP1 mRNA stability	58
tRNA-derived fragments (tRFs): establishing their turf in post-transcriptional gene regulation	57
Multidrug efflux transporter ABCG2: expression and regulation	56
GABAergic signaling by cells of the immune system: more the rule than the exception	56
DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity	56
The protective effect of selenoprotein M on non-alcoholic fatty liver disease: the role of the AMPKα1–MFN2 pathway and Parkin mitophagy	56
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies	55
MicroRNA-34a: the bad guy in age-related vascular diseases	55
Liquid–liquid phase separation as an organizing principle of intracellular space: overview of the evolution of the cell compartmentalization concept	55
Anti-inflammatory effect of SGLT-2 inhibitors via uric acid and insulin	55
Adipokines, adiposity, and atherosclerosis	54
Regulation of maternal–fetal metabolic communication	53
A look into retinal organoids: methods, analytical techniques, and applications	52
Viral pathogen-induced mechanisms to antagonize mammalian interferon (IFN) signaling pathway	52
Sensing, signaling and surviving mitochondrial stress	52
AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3	50
Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma	49
Selective autophagy as a therapeutic target for neurological diseases	48
Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets	48
Recent advances in liposome formulations for breast cancer therapeutics	48
Nonsense suppression therapies in human genetic diseases	48
The pre-metastatic niche in lymph nodes: formation and characteristics	48
Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology	48
CDK9 keeps RNA polymerase II on track	47
Cortical bone development, maintenance and porosity: genetic alterations in humans and mice influencing chondrocytes, osteoclasts, osteoblasts and osteocytes	45
Mechanisms that regulate the activities of TET proteins	45
Metabolomics and health: from nutritional crops and plant-based pharmaceuticals to profiling of human biofluids	45
Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis	45
The circadian clock and metabolic homeostasis: entangled networks	44
The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogenesis	44
Oxidative stress response pathways in fungi	44
An emerging potential of metabolomics in multiple sclerosis: a comprehensive overview	43
The dark-side of the outside: how extracellular heat shock proteins promote cancer	43
Estrogen receptor-α signaling in post-natal mammary development and breast cancers	42
WNT and NOTCH signaling in human trophoblast development and differentiation	42
Initiation and progression of α-synuclein pathology in Parkinson’s disease	42
Molecular mechanisms of doxorubicin-induced cardiotoxicity: novel roles of sirtuin 1-mediated signaling pathways	42
Transcription factor networks in trophoblast development	42

Contribution of specific ceramides to obesity-associated metabolic diseases	42
5-Aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism	41
Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants	41
GAGA factor: a multifunctional pioneering chromatin protein	41
The double-membrane vesicle (DMV): a virus-induced organelle dedicated to the replication of SARS-CoV-2 and other positive-sense single-stranded RNA viruses	41
SIRT7 in the aging process	41
Early human trophoblast development: from morphology to function	41
Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR	40
The wide and growing range of lamin B-related diseases: from laminopathies to cancer	40
uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells	40
Context-dependent roles of YAP/TAZ in stem cell fates and cancer	40
The impact of obesity on adipocyte-derived extracellular vesicles	40
Mfn2-mediated mitochondrial fusion promotes autophagy and suppresses ovarian cancer progression by reducing ROS through AMPK/mTOR/ERK signaling	39
Macrophages evoke autophagy of hepatic stellate cells to promote liver fibrosis in NAFLD mice via the PGE2/EP4 pathway	39
Mitochondrial network remodeling: an important feature of myogenesis and skeletal muscle regeneration	39
Genomics of Alzheimer’s disease implicates the innate and adaptive immune systems	39
Hematopoietic responses to SARS-CoV-2 infection	38
The role of metabolic reprogramming in tubular epithelial cells during the progression of acute kidney injury	38
Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview	38
Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases	38
The role of micropeptides in biology	38
Mechanisms of neuronal dysfunction in HIV-associated neurocognitive disorders	38
The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses	38
At the heart of mitochondrial quality control: many roads to the top	38
Mesenchymal stem cell-mediated transfer of mitochondria: mechanisms and functional impact	37
New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis	37
Regulatory mechanisms of neutrophil migration from the circulation to the airspace	37
The role of SLC transporters for brain health and disease	37
DExD/H-box helicases: multifunctional regulators in antiviral innate immunity	37
Integrin-linked kinase (ILK): the known vs. the unknown and perspectives	36
Vault RNAs: hidden gems in RNA and protein regulation	36
Plastin 3 in health and disease: a matter of balance	36
Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1	36
Mitochondrial function in spinal cord injury and regeneration	36
Tuning the ignition of CAR: optimizing the affinity of scFv to improve CAR-T therapy	36
Mitochondrial microRNA (MitomiRs) in cancer and complex mitochondrial diseases: current status and future perspectives	35
The Hsp70–Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration	35
Structure and function of adenosine receptor heteromers	35
Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19	35
Post-transcriptional regulation in spermatogenesis: all RNA pathways lead to healthy sperm	35
Control of the eIF4E activity: structural insights and pharmacological implications	35
Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury	35
Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies	35
How trophoblasts fuse: an in-depth look into placental syncytiotrophoblast formation	35
Senescence under appraisal: hopes and challenges revisited	34
Epigenetic regulations in mammalian spermatogenesis: RNA-m6A modification and beyond	34
Aquaporin-3 is involved in NLRP3-inflammasome activation contributing to the setting of inflammatory response	34
Alpha and beta myosin isoforms and human atrial and ventricular contraction	34
Meiotic sex chromosome inactivation and the XY body: a phase separation hypothesis	34
Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation	34
Metabolic reprogramming consequences of sepsis: adaptations and contradictions	33
Vitamin K1 inhibits ferroptosis and counteracts a detrimental effect of phenprocoumon in experimental acute kidney injury	33
Snake venom phospholipase A2s exhibit strong virucidal activity against SARS-CoV-2 and inhibit the viral spike glycoprotein interaction with ACE2	33
eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity	33
Experimental colonization with Blastocystis ST4 is associated with protective immune responses and modulation of gut microbiome in a DSS-induced colitis mouse model	33
Animal regeneration in the era of transcriptomics	33
Mitochondrial dynamics in cancer stem cells	32
The present and future of immunocytokines for cancer treatment	32
Contribution of ADAM17 and related ADAMs in cardiovascular diseases	32
Overexpression of laminin-5 gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade	32
The crosstalk between viral RNA- and DNA-sensing mechanisms	32
Emerging role of S100B protein implication in Parkinson’s disease pathogenesis	32
Hippo/YAP signaling pathway protects against neomycin-induced hair cell damage in the mouse cochlea	32
Role of tertiary lymphoid organs in the regulation of immune responses in the periphery	32
Immune responses and therapeutic options in psoriasis	32
Twist1 regulates macrophage plasticity to promote renal fibrosis through galectin-3	32
Cytochrome P450 CYP709C56 metabolizing mesosulfuron-methyl confers herbicide resistance in Alopecurus aequalis	32
Approach for in vivo delivery of CRISPR/Cas system: a recent update and future prospect	31
SOX9 in organogenesis: shared and unique transcriptional functions	31
Platelet-released extracellular vesicles: the effects of thrombin activation	31
The hemogenic endothelium: a critical source for the generation of PSC-derived hematopoietic stem and progenitor cells	31
Mesenchymal stem cell-based treatments for COVID-19: status and future perspectives for clinical applications	31
Sonic hedgehog signaling in astrocytes	31
Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells	31
Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection	30
The effects of codon bias and optimality on mRNA and protein regulation	30
Follicular helper T cells: potential therapeutic targets in rheumatoid arthritis	30
Systems biology of resurrection plants	30
RIPK3 signaling and its role in the pathogenesis of cancers	30
Transcriptional enhancers and their communication with gene promoters	30

Speaking the language of lipids: the cross-talk between plants and pathogens in defence and disease	30
Neurovascular regulation in diabetic retinopathy and emerging therapies	29
Receptor tyrosine kinase inhibitors in cancer	29
Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types	29
What can urinary exosomes tell us?	29
ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation	29
Mitochondrial dynamics, positioning and function mediated by cytoskeletal interactions	29
Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice	28
Outlook on next-generation probiotics from the human gut	28
Circulating extracellular vesicles and rheumatoid arthritis: a proteomic analysis	28
Sestrin2 protects against lethal sepsis by suppressing the pyroptosis of dendritic cells	28
Effects of pH alterations on stress- and aging-induced protein phase separation	28
Inhibitory control in neuronal networks relies on the extracellular matrix integrity	28
The role of mitonuclear incompatibilities in allopatric speciation	27
Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action	27
ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system	27
Darwin’s agential materials: evolutionary implications of multiscale competency in developmental biology	27
Compartmentalized replication organelle of flavivirus at the ER and the factors involved	27
Design of an improved universal signal peptide based on the α-factor mating secretion signal for enzyme production in yeast	27
Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor	27
Regulatory T cells in rheumatoid arthritis: functions, development, regulation, and therapeutic potential	27
Nanoceria: an innovative strategy for cancer treatment	27
Wnt/β-catenin-driven EMT regulation in human cancers	27
BCL2L13: physiological and pathological meanings	27
Autophagy and the endolysosomal system in presynaptic function	27
Structural and functional comparison of magnesium transporters throughout evolution	27
SOX2-OT induced by PAI-1 promotes triple-negative breast cancer cells metastasis by sponging miR-942-5p and activating PI3K/Akt signaling	27
The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour	27
Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes	26
Antiviral activities and applications of ribosomally synthesized and post-translationally modified peptides (RiPPs)	26
Synaptic homeostats: latent plasticity revealed at the Drosophila neuromuscular junction	26
Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method	26
The Ku complex: recent advances and emerging roles outside of non-homologous end-joining	26
The role of transthyretin in cell biology: impact on human pathophysiology	26
DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation	26
Revealing the hidden reality of the mammalian 12-h ultradian rhythms	26
The multifaceted view of heart problem in Duchenne muscular dystrophy	26
Hypothalamic inflammation in metabolic disorders and aging	26
Neuroserpin: structure, function, physiology and pathology	26
Aging microglia	25
Approaches for characterizing and tracking hospital-associated multidrug-resistant bacteria	25
Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington’s disease mice	25
CircACTR2 in macrophages promotes renal fibrosis by activating macrophage inflammation and epithelial–mesenchymal transition of renal tubular epithelial cells	25
Circular RNAs in EMT-driven metastasis regulation: modulation of cancer cell plasticity, tumorigenesis and therapy resistance	25
IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymore	25
Beyond immunosuppressive effects: dual roles of myeloid-derived suppressor cells in bone-related diseases	25
Upregulation of MDH1 acetylation by HDAC6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage	25
Modeling different types of diabetes using human pluripotent stem cells	25
Idiopathic pulmonary fibrosis and systemic sclerosis: pathogenic mechanisms and therapeutic interventions	25
Cytokine signaling convergence regulates the microglial state transition in Alzheimer’s disease	25
Apoptosis resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides	25
Fly for ALS: Drosophila modeling on the route to amyotrophic lateral sclerosis modifiers	25
A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2	25
Hydrogen peroxide-induced stress acclimation in plants	25
Extracellular vesicle release and uptake by the liver under normo- and hyperlipidemia	24
Transcriptional and post-transcriptional control of epithelial-mesenchymal plasticity: why so many regulators?	24
Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data	24
ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform	24
Inhibition of myostatin and related signaling pathways for the treatment of muscle atrophy in motor neuron diseases	24
Noncoding RNAs in tumor metastasis: molecular and clinical perspectives	24
The structure and phase of tau: from monomer to amyloid filament	24
The versatility and paradox of BMP signaling in endothelial cell behaviors and blood vessel function	24
Preclinical models of epithelial ovarian cancer: practical considerations and challenges for a meaningful application	24
TREM2 promotes cholesterol uptake and foam cell formation in atherosclerosis	24
Mechanisms underlying pre- and postnatal development of the vomeronasal organ	24
The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors	23
Non-canonical roles of canonical telomere binding proteins in cancers	23
Mitofusins: from mitochondria to fertility	23
Enzymology of extracellular NAD metabolism	23
Gene regulatory network from cranial neural crest cells to osteoblast differentiation and calvarial bone development	23
Mitochondrial regulation during male germ cell development	23
The base excision repair process: comparison between higher and lower eukaryotes	23
SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants	23
SETD2: from chromatin modifier to multipronged regulator of the genome and beyond	23
Nanoparticle-based approaches to target the lymphatic system for antitumor treatment	23
Impairment of SARS-CoV-2 spike glycoprotein maturation and fusion activity by nitazoxanide: an effect independent of spike variants emergence	23
lncRNA miR4458HG modulates hepatocellular carcinoma progression by activating m6A-dependent glycolysis and promoting the polarization of tumor-associated macrophages	23
miR-146a regulates insulin sensitivity via NPR3	23
Cardiac regenerative capacity: an evolutionary afterthought?	23
Nucleolin: a cell portal for viruses, bacteria, and toxins	22
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway	22
PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier	22
Long non-coding RNAs: the tentacles of chromatin remodeler complexes	22
Biomechanical cues as master regulators of hematopoietic stem cell fate	22
Sexual determination in zebrafish	22
Mechanisms and therapeutic potential of interactions between human amyloids and viruses	22
SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system	22
Nuclear organization and regulation of the differentiated state	22
The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis	22
Moonlighting enzymes: when cellular context defines specificity	22
DHX9 contributes to the malignant phenotypes of colorectal cancer via activating NF-κB signaling pathway	22
Biological aspects in controlling angiogenesis: current progress	21
ER residential chaperone GRP78 unconventionally relocalizes to the cell surface via endosomal transport	21
Pitx genes in development and disease	21
Circulating cell-specific extracellular vesicles as biomarkers for the diagnosis and monitoring of chronic liver diseases	21