Sleep Medicine

Article	Citations
The best modality and dose of physical activity to improve sleep quality in older adults: A Bayesian dose-response meta-analysis	232
Digital media for sleep education to Chinese immigrants	131
Obstructive sleep apnea, Galectin-3 and cognitive impairment	114
Round trip without sleep – an information system for predicting sleep while driving and detecting disorder or chronic sleep deprivation	111
Nursing interventions for sleep derangements in the postoperative period: a systematic review	107
Sleep quality of patients being followed up at the geriatric outpatient clinic	90
Sodium intake and health outcomes: a systematic review of systematic reviews	73
Sleep-wake state discrepancy: clinical characteristics and effect of cognitive behavioural therapy for insomnia (CBTi)	73
Multi-omics based chronobiological signatures of health risks associated with night shift work	71
A narcolepsy detection paradigm: automated nocturnal detection and notification of sleep onset rapid eye movement periods	61
Real world efficacy of a multicomponent CBTi program with chatbot and AI	60
PreScription DigitaL ThErapEutic For Patients with Insomnia (SLEEP-I): A Protocol for a Pragmatic Randomized Controlled Trial	60
Behavioral prevention and treatment for bedtime problems and night wakings in children aged 0-5 years: a systematic review and meta-analysis of randomized controlled trials	60
Response to medical treatment for obstructive sleep apnea in children assessed using sleep questionnaire	59
Worry, rumination and insomnia in patients with coronary heart disease -a cross-sectional study with long-term follow-up	58
Structural Changes of the Subcortical Gray Structures in Restless Legs Syndrome	57
A survey and interview study exploring UK practicing primary care providers’ management of chronic insomnia in children	56
Drug-induced sleep endoscopy (DISE) and natural sleep endoscopy (NSE)	53
Associations Between Pre-Sleep Intrusive Thoughts, Sleep Difficulties, and Body Temperature in Youth with Mood Disorders	53
The effect of sleep deprivation on early neural (P1, N170, P2) responses to target/non-target stimuli processing in young adult men with Attention Deficit Hyperactivity Disorder (ADHD): An ERP study	51
Achieving Reduced Treatment Time for Obstructive Sleep Apnea Utilizing Surgery First Approach: A Comparison of Traditional versus Novel Techniques	50
Correlates of Sleep disturbance among Peoples living in Jeju Island, Korea	49
Consistent efficacy of once-nightly sodium oxybate regardless of patient demographic and baseline disease characteristics	47
Composite response with once-nightly sodium oxybate: symptom improvement in participants with narcolepsy type 1 in REST-ON	43
Bilateral Hypoglossal Nerve Stimulation Improves Moderate to Severe Obstructive Sleep Apnoea in Participants With and Without Complete Concentric Collapse (BETTER SLEEP)	43

NARCAPA: Benefits of physical activity in children with narcolepsy	43
Samelisant (SUVN-G3031), a Histamine H3 Receptor Inverse Agonist in Animal Models of Sleep Disorders	40
Detecting OFF periods in multiunit activity signals	40
Effects of sleep deprivation in the process of Tau protein dephosphorylation following synthetic torpor in the rat	40
Changes in Alertness Over Consecutive Workdays for Internal Medicine Interns: A Secondary Analysis of the iCOMPARE Trial	39
Race differences in estimates of in-home sleep architecture in diverse populations with and without cognitive impairment	38
Well-Being Therapy as Adjunctive to Sleep Hygiene Improves Sleep and Well-Being in Adults With Poor Sleep and Distress During the COVID-19 Pandemic: A Pilot Randomized Controlled Study	37
Sleep spindle dynamics in stroke patients and controls: an exploratory analysis	37
Clinical features, polysomnography, and genetics association study of Restless Legs syndrome in a Chinese population: a multicenter observational study	36
Sleep-related hallucination is a risk factor for adolescent narcolepsy's depression feelings	36
Sleep and stroke-related delirium: A systematic review and meta-analysis	36
Measurement of narcolepsy symptoms in school-aged children and adolescents	36
SAS-CARE I: Sleep disordered breathing is associated with white matter hyperintensities in stroke patients	35
The impact of pain on depression-related states may be improved with good sleep quality in people with chronic pain conditions: a moderation analysis	35
Sleep lab at home: evaluation of oximetry to provide at-home sleep screening of children	33
Diurnal cortisol variability in apneic and non-apneic male obese youths	33
A Prospective Randomised study to evaluate the efficacy of Propofol-Ketamine (Ketofol ) and dexmedetomidine for performing Drug Induced Sleep Endoscopy (DISE) in patients of Obstructive Sleep Apnea	33
The prevalence of Obstructive Sleep Apnea in Gestational Hypertension: a systematic review	32
Study of associations between chronotype, binge eating disorder and obesity	31
Impact of circadian misalignment based on mediating role of chronotype on impulsivity, depression, anxiety, stress, addiction potential, and boredom: a randomized clinical trial and fMRI study	31
Editorial Board	31
Efficacy of Miniscrew-Assisted Rapid Palatal Expansor (MARPE) treatment to increase nasal cavity dimensions and redirect facial growth in conjunction with otorhinolaryngology and myofunctional therapy	31
Sleep quality is associated with sedentary behavior in older adults: a quantile regression analysis	30
Corrigendum to “Molecular determinants of Obstructive Sleep Apnea” [Sleep Medicine 80, April 2021, 105–112]	29
Learning during sleep – a historical review	29
Adapting the athlete sleep behavior questionnaire (ASBQ) for Arabic-speaking populations: Translation, reliability testing, and validation using classical theory and item response theory	29
Phenotypic interindividual differences in the dynamic structure of sleep in healthy young adults	29
Quality assessment of clinical practice guidelines for adult obstructive sleep apnea: A systematic review	29
Maternal depression and anxiety symptoms across pregnancy and the postnatal period: Modest associations between depression symptoms and infant sleep outcomes	29
Performance of Somno-Art Software compared to polysomnography interscorer variability: A multi-center study	28
Editorial Board	28
False recalls, but not false recognitions, at the DRM paradigm are increased in subjects reporting insomnia symptoms: An online study	28
Insomnia and suicide risk: a multi-study replication and extension among military and high-risk college student samples	27
Frequent, complex and vivid dream-like/hallucinatory experiences during NREM sleep parasomnia episodes	27
Response to Daungsupawong H. and Wiwanitkit V.	27
Are physical therapy interventions effective in improving sleep in people with chronic pain? A systematic review and multivariate meta-analysis	27
The challenges in scoring hypopneas in children: is pulse wave amplitude drop the answer?	27
The Optiflow™ interface for chronic CPAP in infants	27
Obstructive sleep apnea is associated with use of assisted ventilation among children with bronchopulmonary dysplasia hospitalized with respiratory illness: A nationwide inpatient cohort	27
Investigating sleep, stress, and mood dynamics via temporal network analysis	27
Bedtime procrastination in the relationship between self-control and depressive symptoms in medical students: From the perspective of sex differences	27
Reply to letter to the editor: “Serum Homocysteine, obstructive sleep apnea, hypertension and obesity”	27
Latent profiles of multi-dimensional sleep characteristics and association with overweight/obesity in Chinese preschool children	26
Racial and ethnic differences in the receipt of continuous positive airway pressure treatment for obstructive sleep apnea	26
Effectiveness of an intervention program on physical activity in children with narcolepsy type 1	26
The relationship between neurodevelopmental transcriptional programs and insomnia: From Rubinstein-Taybi syndrome into energy metabolism	26
Co-occurrence of anxiety and depressive symptoms, suicidal thoughts, and hopelessness in patients with narcolepsy type 1	26
Response to letter to the editor on guardians of rest? Investigating the gut microbiota in central hypersomnolence disorders	26
Associations between e-cigarette use and sleep health among adults in the United States, NHANES 2015–2018	25
Sleep problems in low income, urban pediatric populations living at different altitudes in Colombia	25

Effectiveness of mandibular advancement devices in the treatment of obstructive sleep apnea and the impact of different body positions on treatment： A systematic review and meta-analysis	25
Sleep disturbances in autism spectrum disorder without intellectual impairment: relationship with executive function and psychiatric symptoms	25
Sleep moderates the association between arterial stiffness and 24-hour blood pressure variability	25
Prevalence of sleep apnea and daytime sleepiness in professional truck drivers	25
The effect of water-based intervention on sleep habits and two sleep-related cytokines in children with autism	25
Virtual reality improves sleep quality and associated symptoms in patients with chronic insomnia	24
Aminoacetone is associated with sleep latency	24
Long time polysomnographic sleep and breathing evaluations in children with CDKL5 deficiency disorder	24
Changed nocturnal levels of stress-related hormones couple with sleep-wake states in the patients with chronic insomnia disorder: A clinical pilot study	24
Resting-state microstate dynamics abnormalities in children with ADHD and co-occurring sleep problems	24
Predictive factors of insomnia during the COVID-19 pandemic in Bangladesh: a GIS-based nationwide distribution	24
The influence of transcranial alternating current stimulation on EEG spectral power during subsequent sleep: A randomized crossover study	24
The effects of bright light therapy on depression and sleep disturbances in patients with Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials	24
Obstructive sleep apnea is associated with worse cognitive outcomes in acute moderate-to-severe traumatic brain injury: A TBI Model Systems study	23
Search filters for systematic reviews and meta-analyses in sleep medicine	23
Sleep disturbances in subjects with autism spectrum disorder: A parental perspective	23
ISarcoPRM to Uncover Sarcopenia in Sleep Disorders	23
Machine learning and geometric morphometrics to predict obstructive sleep apnea from 3D craniofacial scans	23
Perspectives regarding consumer sleep technology and barriers to its use or adoption among adults in the United States	23
Apnea-hypopnea index supplied by CPAP devices: time for standardization?	23
Restless legs syndrome and hypertension in men and women: a propensity score-matched analysis	23
Author's response: “Integrating journalism practices and healthcare: Recommendations for research on sleep disorders and psychiatric disorders”	23
Nocturnal cognitive hyperarousal, perinatal-focused rumination, and insomnia are associated with suicidal ideation in perinatal women with mild to moderate depression	23
Altered brain dynamic functional connectivity in patients with obstructive sleep apnea and its association with cognitive performance	23
Hypersomnolence is associated with non-remission of major depressive disorder	23
The risk factors for probable REM sleep behavior disorder: A case-control study	23
Comparison of longitudinal diary and actigraphy-assessed sleep in pregnant women	22
Psychometric properties of the Insomnia Severity Index in a sample of family dementia caregivers	22
Risk factors and prognosis of acute ischemic stroke related restless legs syndrome	22
Gene co-expression analysis identifies modules related to insufficient sleep in humans	22
Insomnia hyperarousal and sleep-disordered breathing nexus: Another pathway to deprescribing and tapering off	22
Increased use of digital tools in sleep disorders research in response to the COVID-19 challenge: implications for the present and future	22
Insomnia with objective short sleep duration in women with temporomandibular joint disorder: quantitative sensory testing, inflammation and clinical pain profiles	21
Maturational trajectories of non-rapid eye movement slow wave activity and odds ratio product in a population-based sample of youth	21
Insomnia disorder is associated with 24-hour cortical hyperarousal	21
Wake-up stroke is not associated with obstructive sleep apnea	21
Prevalence of restless legs syndrome in adults with epilepsy: A systematic review and meta-analysis of observational studies	21
The correlation between the body shape and otolithic function in patients with obstructive sleep apnea	21
Is there an association between sleep quality and magnitude of capability?	20
Validation of the newly developed Sleep Screening Questionnaire Children and Adolescents (SSQ-CA) with objective sleep measures	20
Association between household solid fuel use for cooking and sleep disturbance in rural China: findings from the China Kadoorie Biobank data	20
Impact of continuous positive airway pressure on cognitive functions in adult patients with obstructive sleep apnea: A systematic review and meta-analysis	20
Resting-state fMRI network efficiency as a mediator in the relationship between the glymphatic system and cognitive function in obstructive sleep apnea hypopnea syndrome: Insights from a DTI-ALPS inve	20
Validity of in-lab and home respiratory polygraphy for detecting obstructive sleep apnea in children	20
Involvement of Galectin-3 in neurocognitive impairment in obstructive sleep apnea via regulating inflammation and oxidative stress through NLRP3	20
Serum homocysteine, obstructive sleep apnea, hypertension and obesity	19
Prevalence of sleep disturbance among Chinese healthcare professionals increases Eastward—caution with position in time zone	19
Editorial Board	19
Movements and behaviors during spontaneous arousals in healthy young adults: an intermediary stage between wakefulness and sleep?	19
REM sleep behavior disorder: Relation between aggressiveness and emotions expressed in dream enactment and cognitive and anxiety/depression status	19
Melanopsin-mediated post-illumination pupillary response (PIPR) correlated with sleep timing, chronotype and overnight urinary 6-sulphatoxymelatonin in older individuals	19
Heated humidified high flow nasal cannula therapy in children with obstructive sleep apnea: A randomized cross-over trial	19
Associations between quantitative susceptibility mapping with male obstructive sleep apnea clinical and imaging markers	19
A multicenter clinical trial for the treatment of sleep-disordered breathing with a non-permanent orthodontic slow expansion oral appliance in children	19
Long-term oral appliance therapy effectiveness for Obstructive Sleep Apnea: an update of the ORANGE study	18
Effects of partial blue light blocking glasses on sleep phase and behavior in schoolchildren: a crossover study	18
Obstructive sleep apnea impact on physiology: insights from a mouse model and a case-control study	18
Representation Learning for Anomaly Detection in Sleep Identifying Pediatric Mouth Breathing through Convolutional Autoencoders	18
Offering parents intervention options for Baby’s Sleep: preliminary findings from the Turkish sample of the OPTIONS study	18
Racial/ethnic disparities in sleep health among adolescents in South Korea: the role of substance use behaviors	18
SURWEY study of solriamfetol: initiation, titration, safety, efficacy, and follow-up experience for patients with OSA in Germany	18
Sleep quality and obstructive sleep apnoea in Indigenous and non-Indigenous Australian children	18
Regulation of CB1R/AMPK/PGC-1α signal pathway on the changes of mitochondria in heart and cardiomyocytes of mice with chronic intermittent hypoxia of different severity	18
Defining the heterogeneity of sleep apnea syndrome: a cluster analysis with implications for patient management	18
Weekend sleep extension (catch-up sleep) is associated with lower incidence of coronary calcium score: the ELSA-Brasil study	18
Effects of time restricted eating on sleep quality and body composition: a systematic review	18
Spring forward and Fall back: effects of biennial time change on parents' stress and sleep	18
Insights on sleep wearables: investigating sleep, sleep-related healthcare, and perceived impacts associated with the use of sleep trackers in Canada	18
Relationship between objective sleep quality and aggressiveness	18
Response to Kawada	17
The Impact of Experimental Sleep Restriction on Neurocognition in Healthy Adolescents	17
Comparison of objective and subjective sleep evaluations based on the presence or absence of insomnia among Japanese city employees	17
Boosting obstructive sleep apnea therapy by non-pharmacological approaches: A network meta-analysis	17
Exposure to short photoperiod helps to restore the ventral subicular lesion induced alterations in sleep wake behaviorin rats	17
Sleep telemedicine in Germany: a developed model	17
Novel metabolic disturbance following noise-induced sleep fragmentation: a pilot study	17
The effect of Pimavenserin on arousal threshold and other endotypic traits in obstructive sleep apnea	17
Non-ablative laser treatment for snoring and obstructive sleep apnea - a controlled randomized double-blind clinical trial	17
Detecting lucid dreams only by submentalis electromyography	17
American Life in Realtime (ALiR): Person-generated health data from Fitbits to assess the multi-level influence of social determinants on sleep and other health outcomes in vulnerable and underserved	17

Auditory stimulation aligned to the ascending phase of theta oscillations during REM sleep	17
Mortality in obstructive sleep apnea syndrome (OSAS) and overlap syndrome (OS): The role of nocturnal hypoxemia and CPAP compliance	17
Real-time implementation of sleep staging using interbeat intervals	17
Trajectories of residual apnea-hypopnea index associated with mask changes in continuous positive airway pressure-treated obstructive sleep apnea patients	17
Laser Lingual Tonsillectomy for Obstructive Sleep Apnea: A Feasibility Study	17
Clinical and polysomnographic characterization of REM sleep behavior disorder: casuistic of a Portuguese sleep medicine center	17
A virtual reality mind-body approach targeting hyperarousal in adolescents with insomnia: new directions for treatment	17
Is optimal always optimal? Chronotype, time-of-day, and children's cognitive performance in remote neuropsychological assessment	17
K-complex and heart rate dynamics during varying arousal levels in human NREM sleep	17
Obstructive sleep apnea and long sleep are associated with increased genetic risk of incident Diabetes Mellitus: the Hispanic Community Health Study/Study of Latinos	17
Let's talk about sleep: a qualitative study on the attitude, perception, and management of insomnia in South Asian ethnic minorities in Hong Kong	17
Studio elettrofisiologico del tronco-encefalico nella sindrome delle apnee ostruttive del sonno e valutazione dell’effetto della terapia con CPAP	17
Evaluation of a Womb-Like Sensory Intervention to Improve Infant Sleep	16
Visualizing insomnia phenotypes using dimensionality reduction techniques	16
Comparative Efficacy of OSA Patients Undergoing Multilevel Surgery Followed by Upper Airway Stimulation versus Isolated Upper Airway Stimulation	16
Sleep-wake patterns and insomnia symptoms on the first COVID-19 pandemic wave in Portugal	16
Path to diagnosis and impact of narcolepsy on quality of life: a survey of people living with narcolepsy	16
Short sleep duration is associated with suicidal ideation during the COVID-19 outbreak in medical students: a longitudinal cohort study	16
Editorial Board	16
Sleep breathing disorders in pediatric patients with spinal muscular atrophy 2	16
Cortical hemodynamic changes associated with sleep slow waves in school-age children	16
Sleep health and health-related quality of life among older adults living with HIV	16
Validation of the Japanese version of Stress and Anxiety to Viral Epidemics-9 (SAVE-9) and relationship among stress, insomnia, anxiety, and depression in healthcare workers exposed to coronavirus dis	16
Stratification of patients with idiopathic Rem Behavior Disease patients (iRBD) based on principal component analysis and multivariate machine learning models: an useful statistical tool for clinical	16
Trends in sleep duration in Korea: The Korean time use survey	16
Exposure to screens and changes in toddlers’ sleep during COVID era	16
Associations of evening-type and insomnia symptoms with depressive symptoms among youths	15
The influence of neuroticism on insomnia: The chain mediating effect of mind wandering and symptom rumination	15
Varenicline administration for smoking cessation may reduce apnea hypopnea index in sleep apnea patients	15
Effects of sleep on brain perivascular space in a cognitively healthy population	15
Reliability and validity of the Chinese version of Narcolepsy Severity Scale in adult patients with narcolepsy type 1	15
Corrigendum to “Prevalence of attention deficit hyperactivity disorder symptoms in narcolepsy: A systematic review” [Sleep Med 65 (2020) 84–88]	15
The role of daytime napping in declarative memory performance: a systematic review	15
Melatonin use in infants and toddlers	15
Bright light alone or combined with caffeine improves sleepiness in chronically sleep-restricted young drivers	15
The association of sleep duration and leukocyte telomere length in middle-aged and young-old adults: A cross-sectional study of UK Biobank	15
The treatment of sleep dysfunction to improve cognitive function: A meta-analysis of randomized controlled trials	15
Application of the Sleep Disturbance Scale for Children (SDSC) in infants and toddlers (6–36 months)	15
A randomized controlled trial of a behavioral intervention for decreasing bedtime procrastination using a wait-list control group in a non-clinical sample of young adults	15
Distinguishing between children referred for assessment of excessive daytime sleepiness using polysomnographic measures	15
Solriamfetol real world experience study (SURWEY): Initiation, titration, safety, effectiveness, and experience during follow-up for patients with narcolepsy from Germany	15
Does time of the day matter? Temporal associations between physical activity and quality and quantity of subsequent sleep in adolescents	14
How do infant feeding method, sleeping location, and postpartum depression interact with maternal sleep quality?	14
Maturation-dependent changes in cortical and thalamic activity during sleep slow waves: Insights from a combined EEG-fMRI study	14
Racial disparities in sleep health between Black and White young adults: The role of neighborhood safety in childhood	14
Core body temperature changes in school-age children with circadian rhythm sleep–wake disorder	14
Adjunct pharmacotherapy after upper airway surgery for obstructive sleep apnea: preliminary results of a parallel-group, double-blind, randomized trial.	14
Short sleep duration is associated with a wide variety of medical conditions among United States military service members	14
Aperiodic and periodic components of resting-state EEG in primary insomnia	14
Psychometric analysis of a Chinese version of the Sleep Hygiene Index in nursing students in China: a cross-sectional study	14
Post-stroke sleep disturbance and recurrent cardiovascular and cerebrovascular events: A systematic review and meta-analysis	14
The management of residual OSA post-adenotonsillectomy in children with down syndrome: The experience of a large tertiary sleep service	14
Sleep disorders causally affect the brain cortical structure: A Mendelian randomization study	14
Assessing sleep quality of professional drivers: an analysis based on self-perceived and sleep companions' feedback	14
Acute and long-term effects of acetazolamide in presumed high loop gain sleep apnea	14
Association of sleep duration and napping with stroke mortality in older Chinese: A 14-year prospective cohort study of the Guangzhou Biobank Cohort study	14
Objectively-measured sleep characteristics and the associated factors among rural and urban in-school Nigerian adolescents	14
Correlation between changes of sleep quality and brain functional connectivity patterns in COVID-19 patients: A three-month longitudinal cohort study	14
Ramadan fasting observance is associated with decreased sleep duration, increased daytime sleepiness and insomnia symptoms among student-athletes	14
Association between sleep disorders and cancer using data from the National Health and Nutrition Examination Survey (NHANES) 2005-2014	14
Understanding narcolepsy treatments from the patient’s perspective: a survey of people living with narcolepsy	13
The impact of Takayasu arteritis on diagnosis and treatment of sleep apnea	13
It's the sentiment that counts: a comparison of sentiment analysis models for detecting dream valence	13
Evaluating the circadian and sleep deprivation effects on short inter stimulus intervals in the PVT	13
Editorial Board	13
Association of nocturia with weight status by race and ethnicity in American women	13
Can cry tolerance be increased in mothers of infants with sleep problems, and why does it matter? A quasi-experimental study	13
The impact of sleep disturbance on physical health in a severe asthmatic pediatric population	13
Integration of drowsiness management tools: experience of three different tools in the mining area	13
Variation of quality of life in patients with obstructive sleep apnea hipopnea syndrome after treatment with mandibular advance device	13
High-Risk of Obstructive Sleep Apnea Among Patients with Atrial Fibrillation	13
Effects of haloperidol on low gamma oscillations of the EEG	13
Enrichment of melanopsin genetic variants in a Delayed Sleep-Wake Phase Disorder (DSWPD) patient – whole genome sequencing analysis	13
Particle generation during positive airway pressure therapy	13
Gastroesophageal reflux-related Non-Rapid Eye Movement parasomnia mimicking sleep-related hypermotor epilepsy	13
Influence of social jet lag on weight loss and food intake in bariatric patients: a one-year follow-up study	13
Orienting causal relationships between sleep and adiposity traits using Mendelian randomisation	13
Pulse wave amplitude drops (PWAD) : a new biomarker of cardiovascular risk in patients with obstructive sleep apnea in HypnoLaus and ISAACC cohorts	13
The Effect of Sleeping Position on the Efficacy of Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea	13
Genetic hemochromatosis is not a risk factor for Restless Legs Syndrome	13
Migraton, mental health and sleep	13
The effect of sleep deprivation on food choice certainty: a pilot study	13
Effects of a work schedule with reduced quick returns on insomnia, sleepiness and work-related fatigue among healthcare workers: a large-scale cluster randomized controlled trial	13
Vigilance during recurrent variable and stable short sleep schedules in young adults	13
Resolution of central sleep apnea after percutaneous coronary intervention (PCI) with DES implantation- a case study	13
Longitudinal associations of insufficient sleep duration and insomnia with obesity from adolescence to young adulthood in the GINIplus and LISA studies	13
Editorial Board	12
Eveningness is associated with sedentary behavior and increased cardiovascular risk – data from the SCAPIS pilot cohort	12
Prevalence of sleep complaints among army servicemen after war experience	12
High amplitude delta rhythm related cataplexy in a boy with Niemann-Pick type C disease	12
Effects of sleep deprivation on sleepwalking: Role of sleepwalkers’ clinical characteristics	12
Effect of Telemonitoring on CPAP compliance during CPAP initiation	12
Sleep disordered breathing since childhood associated with atherosclerosis in adulthood	12
My two front teeth	12
Association between nasal airway minimal cross-sectional areas and obstructive sleep apnea	12