OOIR: Observatory of International Research

Papers

(The TQCC of Biogerontology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging	190
Beyond balance: the impact of adult sex ratios on reproduction and longevity in Zophobas morio rearing	116
The crosstalk between CNS resident glial cells and peripheral immune cells is critical for age-dependent demyelination and subsequent remyelination	86
From sick care to healthspan: educating the longevity physician for health maintenance and health promotion	57
Effects of exhaustive and/or strenuous exercise on aging-related molecular and physiological biomarkers: a systematic review and meta-analysis	54
Cytoskeleton-associated protein 4: a double-edged sword in cell growth and aging	51
Transcriptomic insights into the healthspan-enhancing effects of C. chinensis seed and E. ulmoides bark extracts in Caenorhabditis elegans	51
Verbascoside from Callicarpa nudiflora Hook extends lifespan in Caenorhabditis elegans via SKN-1 pathway activation	49
Sirtuin 1 as an emerging exerkine in the aging process: unveiling its multifaceted biological roles	43
Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies	38
CD47 signaling in aging and age-related diseases: mechanisms, challenges, and therapeutic opportunities	37
Transcriptional activation of genes associated with the matrisome is a common feature of senescent endothelial cells	36
Forkhead box P1 transcriptionally activates IGF-1 to lighten ox-LDL-induced endothelial cellular senescence by inactivating NLRP3 inflammasome	35
Bridging expectations and science: a roadmap for the future of longevity interventions	35
First-generation versus next-generation epigenetic aging clocks: Differences in performance and utility	34
Reproduction and preference to macronutrients have different relations to biological or chronological age in Drosophila	33
Proteostasis networks in aging: novel insights from text-mining approaches	32
Correction: Gerontology lost in translation from demography to biology of aging and back	31
Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components	31
Roles of genistein in learning and memory during aging and neurological disorders	30
Empagliflozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress	28
Investigating fasting for metabolic health and longevity	26
Farnesoid X receptor deficiency accelerates aging and systemic functional decline in male mice	26
Long-term dietary restriction ameliorates ageing-related renal fibrosis in male mice by normalizing mitochondrial functions and autophagy	25
Lifespan stops at death, but when does healthspan stop?	24

Insights on the role of l-lactate as a signaling molecule in skin aging	24
Advancements in the investigation of the mechanisms underlying cognitive aging	24
Investigating the aging-modulatory mechanism of Rasayana Churna, an Ayurvedic herbal formulation, using a computational approach	23
Oxygen transport across the lifespan of male Sprague Dawley rats	23
Immune genes involved in synaptic plasticity during early postnatal brain development contribute to post-stroke damage in the aging male rat brain	23
Correction: Immune genes involved in synaptic plasticity during early postnatal brain development contribute to post-stroke damage in the aging male rat brain	22
Melatonin’s role in ameliorating perturbed circadian immune molecular links with aging and sleep deprivation in central and peripheral clocks in male Wistar rats	22
From fat to fate: how aging adipose tissue drives systemic metabolic aging	21
Integrated single-cell multi-omics profiling reveals a senescence-associated hematopoietic landscape and regulatory network in aging bone marrow	21
A multi-tissue integration of immunocytes and inflammaging biomarkers predicts biological age through LASSO-optimized modeling	21
Liu Jun Zi Decoction extends lifespan and healthspan through p16/p21 signaling in Caenorhabditis elegans	20
miRNA changes with ageing and caloric restriction in male rat skeletal muscle: potential roles in muscle cell function	20
Marital and living status and biological ageing trajectories: a longitudinal cohort study with a 20-year follow-up	19
Selective resilience in brain aging: challenging the scope of the disposable soma theory	19
Intracellular cytokines in peritoneal leukocytes relate to lifespan in aging and long-lived female mice	19
Dimethyl fumarate ameliorates quinolinic acid-induced ageing and neurodegeneration in Caenorhabditis elegans	18
Aging is not a disease: an evolutionary and comparative biological reappraisal	18
Metformin promotes healthspan by attenuating frailty and preserving musculoskeletal function–structure in middle-aged mice	18
Changing chronomics of clock, immune and Parkinson’s disease-associated genes in SCN and SN with aging in male Wistar rats: ketogenic diet intervention	18
ATM and p53 in aging and cancer: a double-edged sword in genomic integrity	18
Natural longevity modulator: aging modulatory effects of Eurycoma longifolia Jack polysaccharides in C. elegans and D. melanogaster	17
Disturbances in cell wall biogenesis as a key factor in the replicative aging of budding yeast	16
Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex	16
Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects	16
Consumptıon of ultra-processed foods can accelerate age-related appearance of sarcopenıa	15
A machine learning approach to identify key epigenetic transcripts for ageing research in human blood (Epitage)	15
Harnessing the FOXO-SIRT1 axis: insights into cellular stress, metabolism, and aging	15
Oxidative stress-induced gene expression changes in prostate epithelial cells in vitro reveal a robust signature of normal prostatic senescence and aging	15
Synaptic aging and neurodegeneration: the role of synaptic vesicle dynamics and neurotransmitter imbalance	15
Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis	15
Elucidating the anti-aging bioactive compounds and mechanisms of Jingfang Granules formula based on network pharmacology and Caenorhabditis elegans	15
RNA-binding proteins in aging and age-related diseases: roles, mechanisms, and a large language model analysis	15
An evaluation of aging measures: from biomarkers to clocks	15
Towards a context-aware framework for cellular senescence	14
Day time-restricted feeding shows differential synchronizing effects on age-related changes of serotonin metabolism in SCN and the pineal gland in male Wistar rats	14
Lipid metabolism and ageing in Caenorhabditis elegans: a complex interplay	14
The nexus between peroxisome abundance and chronological ageing in Saccharomyces cerevisiae	14
The pro-aging and rejuvenating effects of young and aged perivascular adipose tissues on endothelial function and inflammation	14
From telomeres and senescence to integrated longevity medicine: redefining the path to extended healthspan	14
Dental pulp and apical papilla cells senescence: causes, consequences, and prevention	14
Zbp1 gene: a modulator of multiple aging hallmarks as potential therapeutic target for age-related diseases	13
The influence of sex-specific factors on biological transformations and health outcomes in aging processes	13
Quercetin preserves mitochondria-endoplasmic reticulum contact sites improving mitochondrial dynamics in aged myocardial cells	13
Alternate day fasting and time-restricted feeding may confer similar neuroprotective effects during aging in male rats	13
Aging adipose tissue, insulin resistance, and type 2 diabetes	13
Beneficial death: A substantial element of evolution?	12
Sex differences in middle-aged and old Wistar rats in response to long-term sulforaphane treatment for prevention of neuroinflammation, cognitive decline and brain senescence	12
The role of different physical exercises as an anti-aging factor in different stem cells	12
Correction: Directionality theory and mortality patterns across the primate lineage	12
Biological properties, synthetic pathways and anti-aging mechanisms of nicotinamide mononucleotide (NMN): Research progress and challenges	12

Age-dependent effects of fibroblast-derived exosomes on keratinocyte differentiation	11
Decoding the impact of ageing and environment stressors on skin cell communication	11
The age-dependent impacts of treadmill exercise on cognitive impairments by reducing inflammation and oxidative stress in the hippocampus of morphine-exposed rats: the role of SIRTs 3 &4 and BDNF	11
Chrysin alleviates the impeded neurogenesis in accelerated brain aging by D-galactose in rats	11
Sex-specific effects of cereal-based diets on longevity and healthspan in Drosophila melanogaster	11
Dauer larva-derived extracellular vesicles extend the life of Caenorhabditis elegans	11
Calorie-restriction treatment mitigates the aging in rat liver model	11
Deciphering the molecular clock: exploring molecular mechanisms and genetic influences on skin ageing	11
The interplay between circadian rhythms and aging: molecular mechanisms and therapeutic strategies	11
Age-related differences in response to plasma exchange in male rat liver tissues: insights from histopathological and machine-learning assisted spectrochemical analyses	11
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity	10
Histone lysine methyltransferases and their specific methylation marks show significant changes in mouse testes from young to older ages	10
Retraction Note: Mitotherapy restores hippocampal mitochondrial function and cognitive impairment in aged male rats subjected to chronic mild stress	10
Aberrant telomeric structures and serum markers of telomere dysfunction in healthy aging: a preliminary study	10
Association of serum metabolites with frailty phenotype and its components: a cross-sectional case–control study	10
Cell-type specific and differential expression of LINC-RSAS long noncoding RNA declines in the testes during ageing of the rat	10
Kaempferol as an ovarian aging-modulatory flavonol‬	10
Shaker potassium channel mediates an age-sensitive neurocardiac axis regulating sleep and cardiac function in Drosophila	10
Directionality theory and mortality patterns across the primate lineage	10
Mitochondria and telomeres: hand in glove	10
Inhibitory immune checkpoints suppress the surveillance of senescent cells promoting their accumulation with aging and in age-related diseases	9
Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach	9
Harnessing the fundamental roles of vitamins: the potent anti-oxidants in longevity	9
The potential link between the development of Alzheimer’s disease and osteoporosis	9
Lifestyle, environment and other major determinants of frailty in older adults: a population-based study from the UK Biobank	9
Chrysin mitigates neuronal apoptosis and impaired hippocampal neurogenesis in male rats subjected to D-galactose-induced brain aging	8
Multi-omics profiling reveals mitochondrial dysfunction and epigenetic dysregulation in postoperative cognitive dysfunction: identification of novel biomarkers in an aged mouse model	8
Therapeutic extracellular vesicles as a cornerstone of medicine in the next decade with gerontological focus	8
Distinguishing the intrinsic and extrinsic causes of changes in human mortality by examining life-table aging rate (LAR) trajectories through the lens of generalized Gompertz-Makeham law	8
High stability of blood parameters during mouse lifespan: sex-specific effects of every-other-day fasting	8
Circadian rhythms in aging and longevity: from molecular chronomics to translational gerontology	8
Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential skin rejuvenation in male mice	8
MSC-derived extracellular vesicles accelerate wound healing in senescent fibroblast cultures	8
Correction: Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease	8
Sustained exposure to high glucose induces differential expression of cellular senescence markers in murine macrophages but impairs immunosurveillance response to senescent cells secretome	8
T-cell lymphocytes’ aging clock: telomeres, telomerase and aging	8
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration	8
The combination of hawthorn extract administration and high-intensity interval training (HIIT) alleviates hippocampus damage in aged rats: the behavioral, molecular and histological evaluations	8
Decreased fatty acid transporter FATP4 is a potential contributor to impaired fat utilization in aging mice	8
Critical roles of m6A demethylase FTO in ovarian aging	7
Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases	7
The potential of flavonoids to mitigate cellular senescence in cardiovascular disease	7
Transcriptomic landscape of human cardiac aging: identification of cardioselective age-associated genes and predictive modeling	7
Alterations in bone metabolites with age in C57BL/6 mice model	7
Tissue stretching is a confounding factor for the evaluation of neurodegeneration in the fast-ageing killifish	7
The age-dependent neuroglial interaction with peripheral immune cells in coronavirus-induced neuroinflammation with a special emphasis on COVID-19	7
“Metabolic memory” of aging: anchoring, transmission, and frontiers of transgenerational intervention	7
Investigating genetic links between biological aging and adverse pregnancy outcomes	7
Isotschimgine promotes lifespan, healthspan and neuroprotection of Caenorhabditis elegans via the activation of nuclear hormone receptors	7
Restricting the level of the proteins essential for the regulation of the initiation step of replication extends the chronological lifespan and reproductive potential in budding yeast	7
Nicotinamide mononucleotide suppresses cellular senescence and increases aquaporin 5 expression in the submandibular gland of aged male mice to ameliorate aging-related dry mouth	7
Variety of sleep and circadian rhythms of elderly dementia patients living in group home residences	7
Enhancing the human health and lifespan: a targeted strategy emphasizing statins	7
Cholesterol’s hidden impact: the nonlinear link between remnant cholesterol (RC) and phenotypic age acceleration (PhenoAgeAccel)	7
Retraction Note: Mapping NAD+ metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence	7
Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging	7
Analyzing different aging theories in the context of the brain: DNA damage, inflammation, redox imbalance, and neurodevelopment intertwine	7
Investigating the protective and therapeutic potential of new generation antioxidant combinations in the brain: an experimental aging model	7
Effects of aging and resistance exercise on muscle strength, physiological properties, longevity proteins, and telomere length in SAMP8 mice	7