OOIR: Observatory of International Research

Papers

(The TQCC of Biogerontology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Prematurely aging female mice improve their behavioural response, immunity, redox state, and lifespan after a short social interaction with non-prematurely aging mice	94
Forkhead box P1 transcriptionally activates IGF-1 to lighten ox-LDL-induced endothelial cellular senescence by inactivating NLRP3 inflammasome	87
Beyond balance: the impact of adult sex ratios on reproduction and longevity in Zophobas morio rearing	49
Transcriptional activation of genes associated with the matrisome is a common feature of senescent endothelial cells	49
The crosstalk between CNS resident glial cells and peripheral immune cells is critical for age-dependent demyelination and subsequent remyelination	47
Bridging expectations and science: a roadmap for the future of longevity interventions	44
No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging	33
First-generation versus next-generation epigenetic aging clocks: Differences in performance and utility	33
Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies	33
Insights on the role of l-lactate as a signaling molecule in skin aging	29
Proteostasis networks in aging: novel insights from text-mining approaches	29
Swimming exercise with l-arginine coated nanoparticles supplementation upregulated HAND2 and TBX5 expression in the cardiomyocytes of aging male rats	27
Investigating the aging-modulatory mechanism of Rasayana Churna, an Ayurvedic herbal formulation, using a computational approach	25
Roles of genistein in learning and memory during aging and neurological disorders	24
Immune genes involved in synaptic plasticity during early postnatal brain development contribute to post-stroke damage in the aging male rat brain	24
Reproduction and preference to macronutrients have different relations to biological or chronological age in Drosophila	22
Retraction Note to: Carbohydrate-restricted diet promotes skin senescence in senescence-accelerated prone mice	22
Ufuk Çakatay (editor): Redox Signaling and Biomarkers in Ageing	22
Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components	21
Long-term dietary restriction ameliorates ageing-related renal fibrosis in male mice by normalizing mitochondrial functions and autophagy	21
Empagliflozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress	21
Oxygen transport across the lifespan of male Sprague Dawley rats	21
Intracellular cytokines in peritoneal leukocytes relate to lifespan in aging and long-lived female mice	19
Marital and living status and biological ageing trajectories: a longitudinal cohort study with a 20-year follow-up	19
ATM and p53 in aging and cancer: a double-edged sword in genomic integrity	18

Correction: Immune genes involved in synaptic plasticity during early postnatal brain development contribute to post-stroke damage in the aging male rat brain	18
Age-dependent effect of continuous ‘artificial light at night’ on circadian rhythm in male rats: neuroprotective role of melatonin	18
Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions	17
Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects	17
Oxidative stress-induced gene expression changes in prostate epithelial cells in vitro reveal a robust signature of normal prostatic senescence and aging	16
An evaluation of aging measures: from biomarkers to clocks	16
Targeting Wnt signaling pathway by polyphenols: implication for aging and age-related diseases	16
Disturbances in cell wall biogenesis as a key factor in the replicative aging of budding yeast	16
Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology	15
Elucidating the anti-aging bioactive compounds and mechanisms of Jingfang Granules formula based on network pharmacology and Caenorhabditis elegans	15
Harnessing the FOXO-SIRT1 axis: insights into cellular stress, metabolism, and aging	15
Consumptıon of ultra-processed foods can accelerate age-related appearance of sarcopenıa	15
Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex	15
Zbp1 gene: a modulator of multiple aging hallmarks as potential therapeutic target for age-related diseases	14
Quercetin preserves mitochondria-endoplasmic reticulum contact sites improving mitochondrial dynamics in aged myocardial cells	14
Lipid metabolism and ageing in Caenorhabditis elegans: a complex interplay	14
The pro-aging and rejuvenating effects of young and aged perivascular adipose tissues on endothelial function and inflammation	14
Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis	14
Day time-restricted feeding shows differential synchronizing effects on age-related changes of serotonin metabolism in SCN and the pineal gland in male Wistar rats	14
G protein-coupled receptors that influence lifespan of human and animal models	13
The influence of sex-specific factors on biological transformations and health outcomes in aging processes	13
Alternate day fasting and time-restricted feeding may confer similar neuroprotective effects during aging in male rats	13
Aging-related changes in metabolic indicators in female rats and their management with Tinospora cordifolia	13
From telomeres and senescence to integrated longevity medicine: redefining the path to extended healthspan	13
Histone lysine methyltransferases and their specific methylation marks show significant changes in mouse testes from young to older ages	13
The nexus between peroxisome abundance and chronological ageing in Saccharomyces cerevisiae	13
Dental pulp and apical papilla cells senescence: causes, consequences, and prevention	13
Aging adipose tissue, insulin resistance, and type 2 diabetes	13
Correction: Directionality theory and mortality patterns across the primate lineage	12
Biological properties, synthetic pathways and anti-aging mechanisms of nicotinamide mononucleotide (NMN): Research progress and challenges	11
Beneficial death: A substantial element of evolution?	11
Decoding the impact of ageing and environment stressors on skin cell communication	11
Chrysin alleviates the impeded neurogenesis in accelerated brain aging by D-galactose in rats	11
The age-dependent impacts of treadmill exercise on cognitive impairments by reducing inflammation and oxidative stress in the hippocampus of morphine-exposed rats: the role of SIRTs 3 &4 and BDNF	10
Dauer larva-derived extracellular vesicles extend the life of Caenorhabditis elegans	10
The role of different physical exercises as an anti-aging factor in different stem cells	10
Green tea EGCG effectively alleviates experimental colitis in middle-aged male mice by attenuating multiple aspects of oxi-inflammatory stress and cell cycle deregulation	10
Calorie-restriction treatment mitigates the aging in rat liver model	10
Sex differences in middle-aged and old Wistar rats in response to long-term sulforaphane treatment for prevention of neuroinflammation, cognitive decline and brain senescence	10
Cell-type specific and differential expression of LINC-RSAS long noncoding RNA declines in the testes during ageing of the rat	9
Directionality theory and mortality patterns across the primate lineage	9
Aberrant telomeric structures and serum markers of telomere dysfunction in healthy aging: a preliminary study	9
Mapping sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential?	9
Age-related differences in response to plasma exchange in male rat liver tissues: insights from histopathological and machine-learning assisted spectrochemical analyses	9
Association of serum metabolites with frailty phenotype and its components: a cross-sectional case–control study	9
Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach	9
Distinguishing the intrinsic and extrinsic causes of changes in human mortality by examining life-table aging rate (LAR) trajectories through the lens of generalized Gompertz-Makeham law	8
Harnessing the fundamental roles of vitamins: the potent anti-oxidants in longevity	8
Inhibitory immune checkpoints suppress the surveillance of senescent cells promoting their accumulation with aging and in age-related diseases	8
Correction: Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease	8

The potential link between the development of Alzheimer’s disease and osteoporosis	8
Lifestyle, environment and other major determinants of frailty in older adults: a population-based study from the UK Biobank	8
High stability of blood parameters during mouse lifespan: sex-specific effects of every-other-day fasting	8
Mitochondria and telomeres: hand in glove	8
The combination of hawthorn extract administration and high-intensity interval training (HIIT) alleviates hippocampus damage in aged rats: the behavioral, molecular and histological evaluations	7
COVID-19 detection in CT and CXR images using deep learning models	7
Chrysin mitigates neuronal apoptosis and impaired hippocampal neurogenesis in male rats subjected to D-galactose-induced brain aging	7
T-cell lymphocytes’ aging clock: telomeres, telomerase and aging	7
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration	7
Sustained exposure to high glucose induces differential expression of cellular senescence markers in murine macrophages but impairs immunosurveillance response to senescent cells secretome	7
Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential skin rejuvenation in male mice	7
The age-dependent neuroglial interaction with peripheral immune cells in coronavirus-induced neuroinflammation with a special emphasis on COVID-19	7
Enhancing the human health and lifespan: a targeted strategy emphasizing statins	6
Cholesterol’s hidden impact: the nonlinear link between remnant cholesterol (RC) and phenotypic age acceleration (PhenoAgeAccel)	6
Telomeres and telomerase: active but complex players in life-history decisions	6
Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging	6
Effects of aging and resistance exercise on muscle strength, physiological properties, longevity proteins, and telomere length in SAMP8 mice	6
Restricting the level of the proteins essential for the regulation of the initiation step of replication extends the chronological lifespan and reproductive potential in budding yeast	6
Investigating genetic links between biological aging and adverse pregnancy outcomes	6
The potential of flavonoids to mitigate cellular senescence in cardiovascular disease	6
Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases	6
Alterations in bone metabolites with age in C57BL/6 mice model	6
Isotschimgine promotes lifespan, healthspan and neuroprotection of Caenorhabditis elegans via the activation of nuclear hormone receptors	6