OOIR: Observatory of International Research

Papers

(The TQCC of Biogerontology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging	40
Long-term detraining reverses the improvement of lifelong exercise on skeletal muscle ferroptosis and inflammation in aging rats: fiber-type dependence of the Keap1/Nrf2 pathway	36
Inhibitory immune checkpoints suppress the surveillance of senescent cells promoting their accumulation with aging and in age-related diseases	33
The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cell	32
Arnold Mitnitski: mathematician who pioneered a new understanding of frailty (1944 – 2021)	28
Prematurely aging female mice improve their behavioural response, immunity, redox state, and lifespan after a short social interaction with non-prematurely aging mice	25
Long-term sulforaphane-treatment restores redox homeostasis and prevents cognitive decline in middleaged female and male rats, but cannot revert previous damage in old animals	23
Renal aging and mitochondrial quality control	23
Simultaneous activation of the hydrogen sulfide biosynthesis genes (CBS and CSE) induces sex-specific geroprotective effects in Drosophila melanogaster	23
Inflammaging in domestic dogs: basal level concentrations of IL-6, IL-1β, and TNF-α in serum of healthy dogs of different body sizes and ages	22
An AMP Kinase-pathway dependent integrated stress response regulates ageing and longevity	21
The potential use of nanozyme in aging and age‐related diseases	21
Mapping sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential?	17
Senescence of bone marrow mesenchymal stem cells in Wistar male rats receiving normal chow/high-calorie diets with/without vitamin D	17
The SGLT2 inhibitor empagliflozin inhibits skeletal muscle fibrosis in naturally aging male mice through the AMPKα/MMP9/TGF-β1/Smad pathway	17
Correlative links between natural radiation and life expectancy in the US population	16
Age and dietary restriction modulate mitochondrial quality in quadriceps femoris muscle of male mice	15
Alexey Olovnikov: theoretical biology beyond the margins	15
Immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older residents of a long-term care facility: relation with age, frailty and prior infection status	14
Aging through the lens of mitochondrial DNA mutations and inheritance paradoxes	14
Cell-type specific and differential expression of LINC-RSAS long noncoding RNA declines in the testes during ageing of the rat	14
Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies	14
Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies	14
Mitochondria and telomeres: hand in glove	14
Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats	14

Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders	13
Aberrant telomeric structures and serum markers of telomere dysfunction in healthy aging: a preliminary study	13
Low-molecular-weight heparin ameliorates intestinal barrier dysfunction in aged male rats via protection of tight junction proteins	13
Level-dependent effects of predation stress on prey development, lifespan and reproduction in mites	12
Forkhead box P1 transcriptionally activates IGF-1 to lighten ox-LDL-induced endothelial cellular senescence by inactivating NLRP3 inflammasome	12
CeO2 nanoparticles improve prooxidant/antioxidant balance, life quality and survival of old male rats	12
Correction: Empaglifozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress	12
Melatonin-related signaling pathways and their regulatory effects in aging organisms	12
Directionality theory and mortality patterns across the primate lineage	11
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders	11
Association of serum metabolites with frailty phenotype and its components: a cross-sectional case–control study	10
Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach	10
GDF-15 as a proxy for epigenetic aging: associations with biological age markers, and physical function	10
Beyond balance: the impact of adult sex ratios on reproduction and longevity in Zophobas morio rearing	10
“Development of gerontology would be more effective under governmental support”: an interview with Vladimir N. Anisimov	9
Age-dependent and modality-specific changes in the phenotypic markers Nav1.8, ASIC3, P2X3 and TRPM8 in male rat primary sensory neurons during healthy aging	9
The potential link between the development of Alzheimer’s disease and osteoporosis	9
Rooibos tea—in the cross fire of ROS, mitochondrial dysfunction and loss of proteostasis—positioned for healthy aging	8
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration	8
Identification of Isthmin1 in the small annual fish, Nothobranchius guentheri, as a novel biomarker of aging and its potential rejuvenation activity	8
Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster	8
The mitochondrial and cytoplasmic superoxide anion imbalance trigger the expression of certain cellular aging markers in HaCaT keratinocytes	8
Ufuk Çakatay (editor): Redox Signaling and Biomarkers in Ageing	8
Network analysis in aged C. elegans reveals candidate regulatory genes of ageing	8
Associations between dietary carotenoid and biological age acceleration: insights from NHANES 2009–2018	7
The potential longevity-promoting hypoxic-hypercapnic environment as a measure for radioprotection	7
Swimming exercise with l-arginine coated nanoparticles supplementation upregulated HAND2 and TBX5 expression in the cardiomyocytes of aging male rats	7
High stability of blood parameters during mouse lifespan: sex-specific effects of every-other-day fasting	7
Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential skin rejuvenation in male mice	7
Insights on the role of l-lactate as a signaling molecule in skin aging	7
Predation stress experienced as immature mites extends their lifespan	7
Geroprotective potential of genetic and pharmacological interventions to endogenous hydrogen sulfide synthesis in Drosophila melanogaster	7
Proteostasis networks in aging: novel insights from text-mining approaches	6
Long-term dietary restriction ameliorates ageing-related renal fibrosis in male mice by normalizing mitochondrial functions and autophagy	6
COVID-19 detection in CT and CXR images using deep learning models	6
The protein cargo of extracellular vesicles correlates with the epigenetic aging clock of exercise sensitive DNAmFitAge	6
The seesaw of diet restriction and lifespan: lessons from Drosophila studies	6
Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model	6
The effect of three types of water-based training protocols on thymus atrophy and specific indicators of cellular immune senescence in aged male rats	6
Middle aged turn point in parameters of oxidative stress and glucose catabolism in mouse cerebellum during lifespan: minor effects of every-other-day fasting	6
Linking telomere dynamics to evolution, life history and environmental change: perspectives, predictions and problems	6
Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster	6
Roles of genistein in learning and memory during aging and neurological disorders	6
Ribose-induced advanced glycation end products reduce the lifespan in Drosophila melanogaster by changing the redox state and down-regulating the Sirtuin genes	6
The influence of biological sex in human skeletal muscle transcriptome during ageing	5
Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes	5
2,4-Dinitrophenol is toxic on a low caloric diet but extends lifespan of Drosophila melanogaster on nutrient-rich diets without an impact on metabolism	5
T-cell lymphocytes’ aging clock: telomeres, telomerase and aging	5
Application potential of senolytics in clinical treatment	5
RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells	5

Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex	5
Investigating cognitive impairments and hippocampal proteome alterations in aged male rats with TAA-Induced minimal hepatic encephalopathy	5
Sustained exposure to high glucose induces differential expression of cellular senescence markers in murine macrophages but impairs immunosurveillance response to senescent cells secretome	5
IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway	5
Piperine improves the health span of Drosophila melanogaster with age- and sex-specific effect	5
A novel rat model of sarcopenic obesity based on aging and high-fat diet consumption	5
Hormesis is an evolutionary expectation: implications for aging	5