OOIR: Observatory of International Research

Papers

(The TQCC of Biogerontology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Aging and age‐related diseases: from mechanisms to therapeutic strategies	189
Natural anti-aging skincare: role and potential	75
Cancer and Alzheimer’s disease: intracellular pH scales the metabolic disorders	31
Targeting reactive oxygen species (ROS) to combat the age-related loss of muscle mass and function	30
COVID-19 detection in CT and CXR images using deep learning models	30
Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice	30
Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and d-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging	29
Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders	27
Mitochondria-targeted senotherapeutic interventions	27
The crosstalk of NAD, ROS and autophagy in cellular health and ageing	24
Evidence from two cohorts for the frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems	24
Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice	23
Sirtuins family as a target in endothelial cell dysfunction: implications for vascular ageing	23
Anti-SASP and anti-inflammatory activity of resveratrol, curcumin and β-caryophyllene association on human endothelial and monocytic cells	20
Identification of longevity compounds with minimized probabilities of side effects	20
Daily ingestion of Akkermansia mucciniphila for one month promotes healthy aging and increases lifespan in old female mice	19
Novel biomarkers for the evaluation of aging-induced proteinopathies	19
A collective analysis of lifespan-extending compounds in diverse model organisms, and of species whose lifespan can be extended the most by the application of compounds	19
Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology	18
The greatest risk factor for the leading cause of death is ignored	18
Biochemical, structural and physical changes in aging human skin, and their relationship	18
Mapping sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential?	18
Lipids: biomarkers of healthy aging	17
Multiparameter flow cytometric detection and quantification of senescent cells in vitro	15
Epigenetic changes during ageing and their underlying mechanisms	15

Immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older residents of a long-term care facility: relation with age, frailty and prior infection status	14
Astaxanthin protects oxidative stress mediated DNA damage and enhances longevity in Saccharomyces cerevisiae	14
Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies	14
Alterations in hippocampal mitochondrial dynamics are associated with neurodegeneration and recognition memory decline in old male mice	14
Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster	14
MetaboAge DB: a repository of known ageing-related changes in the human metabolome	14
Identification of Isthmin1 in the small annual fish, Nothobranchius guentheri, as a novel biomarker of aging and its potential rejuvenation activity	13
Enhancing health span: muscle stem cells and hormesis	13
17β-estradiol inhibits H2O2-induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy	13
The roles of MTOR and miRNAs in endothelial cell senescence	12
The redox environment and mitochondrial dysfunction in age-related skeletal muscle atrophy	12
Analysis of longevity in Chordata identifies species with exceptional longevity among taxa and points to the evolution of longer lifespans	12
Male sex hormones, aging, and inflammation	11
Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans	11
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies	11
Inhibition of mTOR decreases insoluble proteins burden by reducing translation in C. elegans	11
Targeting Wnt signaling pathway by polyphenols: implication for aging and age-related diseases	11
Tracing skin aging process: a mini- review of in vitro approaches	10
Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response	10
Melatonin-related signaling pathways and their regulatory effects in aging organisms	10
Sarcopenia versus cancer cachexia: the muscle wasting continuum in healthy and diseased aging	10
Functional alterations and transcriptomic changes during zebrafish cardiac aging	10
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders	10
G protein-coupled receptors that influence lifespan of human and animal models	10
Contribution of senescent and reactive astrocytes on central nervous system inflammaging	10
Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex	10
Age-related chemokine alterations affect IgA secretion and gut immunity in female mice	9
Role of a small GTPase Cdc42 in aging and age-related diseases	9
Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function	8
Geroprotective potential of genetic and pharmacological interventions to endogenous hydrogen sulfide synthesis in Drosophila melanogaster	8
The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1	8
Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts	8
Non-coding RNAs in photoaging-related mechanisms: a new paradigm in skin health	8
Informative frailty indices from binarized biomarkers	8
Green tea EGCG effectively alleviates experimental colitis in middle-aged male mice by attenuating multiple aspects of oxi-inflammatory stress and cell cycle deregulation	8
Geroscience: the need to address some issues	8
Longevity-promoting efficacies of rutin in high fat diet fed Drosophila melanogaster	8
Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes	8
A Bioactive compound Shatavarin IV-mediated longevity as revealed by dietary restriction-induced autophagy in Caenorhabditis elegans	8
Effects of lifelong exercise and aging on the blood metabolic fingerprint of rats	8
Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats	8