OOIR: Observatory of International Research

Papers

(The median citation count of Biogerontology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Aging and age‐related diseases: from mechanisms to therapeutic strategies	189
Natural anti-aging skincare: role and potential	75
Cancer and Alzheimer’s disease: intracellular pH scales the metabolic disorders	31
COVID-19 detection in CT and CXR images using deep learning models	30
Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice	30
Targeting reactive oxygen species (ROS) to combat the age-related loss of muscle mass and function	30
Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and d-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging	29
Mitochondria-targeted senotherapeutic interventions	27
Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders	27
The crosstalk of NAD, ROS and autophagy in cellular health and ageing	24
Evidence from two cohorts for the frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems	24
Sirtuins family as a target in endothelial cell dysfunction: implications for vascular ageing	23
Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice	23
Anti-SASP and anti-inflammatory activity of resveratrol, curcumin and β-caryophyllene association on human endothelial and monocytic cells	20
Identification of longevity compounds with minimized probabilities of side effects	20
A collective analysis of lifespan-extending compounds in diverse model organisms, and of species whose lifespan can be extended the most by the application of compounds	19
Daily ingestion of Akkermansia mucciniphila for one month promotes healthy aging and increases lifespan in old female mice	19
Novel biomarkers for the evaluation of aging-induced proteinopathies	19
Biochemical, structural and physical changes in aging human skin, and their relationship	18
Mapping sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential?	18
Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology	18
The greatest risk factor for the leading cause of death is ignored	18
Lipids: biomarkers of healthy aging	17
Epigenetic changes during ageing and their underlying mechanisms	15
Multiparameter flow cytometric detection and quantification of senescent cells in vitro	15

Alterations in hippocampal mitochondrial dynamics are associated with neurodegeneration and recognition memory decline in old male mice	14
Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster	14
MetaboAge DB: a repository of known ageing-related changes in the human metabolome	14
Immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older residents of a long-term care facility: relation with age, frailty and prior infection status	14
Astaxanthin protects oxidative stress mediated DNA damage and enhances longevity in Saccharomyces cerevisiae	14
Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies	14
Enhancing health span: muscle stem cells and hormesis	13
17β-estradiol inhibits H2O2-induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy	13
Identification of Isthmin1 in the small annual fish, Nothobranchius guentheri, as a novel biomarker of aging and its potential rejuvenation activity	13
The redox environment and mitochondrial dysfunction in age-related skeletal muscle atrophy	12
Analysis of longevity in Chordata identifies species with exceptional longevity among taxa and points to the evolution of longer lifespans	12
The roles of MTOR and miRNAs in endothelial cell senescence	12
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies	11
Inhibition of mTOR decreases insoluble proteins burden by reducing translation in C. elegans	11
Targeting Wnt signaling pathway by polyphenols: implication for aging and age-related diseases	11
Male sex hormones, aging, and inflammation	11
Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans	11
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders	10
G protein-coupled receptors that influence lifespan of human and animal models	10
Contribution of senescent and reactive astrocytes on central nervous system inflammaging	10
Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex	10
Tracing skin aging process: a mini- review of in vitro approaches	10
Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response	10
Melatonin-related signaling pathways and their regulatory effects in aging organisms	10
Sarcopenia versus cancer cachexia: the muscle wasting continuum in healthy and diseased aging	10
Functional alterations and transcriptomic changes during zebrafish cardiac aging	10
Age-related chemokine alterations affect IgA secretion and gut immunity in female mice	9
Role of a small GTPase Cdc42 in aging and age-related diseases	9
Green tea EGCG effectively alleviates experimental colitis in middle-aged male mice by attenuating multiple aspects of oxi-inflammatory stress and cell cycle deregulation	8
Geroscience: the need to address some issues	8
Longevity-promoting efficacies of rutin in high fat diet fed Drosophila melanogaster	8
Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes	8
A Bioactive compound Shatavarin IV-mediated longevity as revealed by dietary restriction-induced autophagy in Caenorhabditis elegans	8
Effects of lifelong exercise and aging on the blood metabolic fingerprint of rats	8
Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats	8
Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function	8
Geroprotective potential of genetic and pharmacological interventions to endogenous hydrogen sulfide synthesis in Drosophila melanogaster	8
The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1	8
Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts	8
Non-coding RNAs in photoaging-related mechanisms: a new paradigm in skin health	8
Informative frailty indices from binarized biomarkers	8
An essay on the nominal vs. real definitions of aging	7
The role of NAD and NAD precursors on longevity and lifespan modulation in the budding yeast, Saccharomyces cerevisiae	7
Dietary intake of microplastics impairs digestive performance, induces hepatic dysfunction, and shortens lifespan in the annual fish Nothobranchius guentheri	7
ATP-dependent chromatin remodelers in ageing and age-related disorders	7
Tectochrysin increases stress resistance and extends the lifespan of Caenorhabditis elegans via FOXO/DAF-16	7
Insights on the role of l-lactate as a signaling molecule in skin aging	7
Age-dependent effect of continuous ‘artificial light at night’ on circadian rhythm in male rats: neuroprotective role of melatonin	6
Background radiation impacts human longevity and cancer mortality: reconsidering the linear no-threshold paradigm	6
Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions	6

Dietary intake of diosgenin delays aging of male fish Nothobranchius guentheri through modulation of multiple pathways that play prominent roles in ROS production	6
The sciences of healthy aging await a theory of health	6
Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components	6
Gastrointestinal redox homeostasis in ageing	6
Responsible biology, aging populations and the 50th anniversary of the “War on Cancer”	5
Production and scavenging of reactive oxygen species both affect reproductive success in male and female Drosophila melanogaster	5
No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging	5
Lipid metabolism and ageing in Caenorhabditis elegans: a complex interplay	5
Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases	5
Dietary intervention with Tinospora cordifolia improved aging-related decline in locomotor coordination and cerebellar cell survival and plasticity in female rats	5
AI-based investigation of molecular biomarkers of longevity	5
Signaling mechanisms underlying lymphatic vessel dysfunction in skin aging and possible anti-aging strategies	5
Effect of long-term moderate-exercise combined with metformin-treatment on antioxidant enzymes activity and expression in the gastrocnemius of old female Wistar rats	5
Application of lipidomics strategy to explore aging-related biomarkers and potential anti-aging mechanisms of ginseng	4
Aging-related changes in metabolic indicators in female rats and their management with Tinospora cordifolia	4
Middle aged turn point in parameters of oxidative stress and glucose catabolism in mouse cerebellum during lifespan: minor effects of every-other-day fasting	4
Hormesis is an evolutionary expectation: implications for aging	4
Characterisation of the positive effects of mild stress on ageing and resistance to stress	4
3-Bromopyruvate, a caloric restriction mimetic, exerts a mitohormetic effect to provide neuroprotection through activation of autophagy in rats during aging	4
Overexpression of a single ORF can extend chronological lifespan in yeast if retrograde signaling and stress response are stimulated	4
High stability of blood parameters during mouse lifespan: sex-specific effects of every-other-day fasting	4
Prematurely aging female mice improve their behavioural response, immunity, redox state, and lifespan after a short social interaction with non-prematurely aging mice	4
Ginseng volatile oil prolongs the lifespan and healthspan of Caenorhabditis elegans	4
Development of fly tolerance to consuming a high-protein diet requires physiological, metabolic and transcriptional changes	4
Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells	4
Aging disrupts the temporal organization of antioxidant defenses in the heart of male rats and phase shifts circadian rhythms of systolic blood pressure	4
Hormetic association between perceived stress and human epigenetic aging based on resilience capacity	3
Empagliflozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress	3
Metabolic and physical function are improved with lifelong 15% calorie restriction in aging male mice	3
The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cell	3
Aging and short-term calorie restriction differently affect the cardiac and skeletal muscle expression of genes regulating energy substrate utilization in male rats	3
Sex-related differences in behavioural markers in adult mice for the prediction of lifespan	3
SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway	3
Dynamics of redox signaling in aging via autophagy, inflammation, and senescence	3
Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts	3
The seesaw of diet restriction and lifespan: lessons from Drosophila studies	3
d-galactose: a model of accelerated ageing sufficiently sensitive to reflect preventative efficacy of an antioxidant treatment	3
SIRT4 in ageing	3
Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study	3
Hypertension and cellular senescence	3
The nexus between peroxisome abundance and chronological ageing in Saccharomyces cerevisiae	3
IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway	3
Dietary intake of GDF11 delays the onset of several biomarkers of aging in male mice through anti-oxidant system via Smad2/3 pathway	3
An AMP Kinase-pathway dependent integrated stress response regulates ageing and longevity	3
Lack of age-related respiratory changes in Daphnia	3
A mild heat stress increases resistance to heat of dFOXO Drosophila melanogaster mutants but less in wild-type flies	3
Tackling cellular senescence by targeting miRNAs	3
Dietary interventions and molecular mechanisms for healthy musculoskeletal aging	3