Biogerontology

Article	Citations
No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging	40
Long-term detraining reverses the improvement of lifelong exercise on skeletal muscle ferroptosis and inflammation in aging rats: fiber-type dependence of the Keap1/Nrf2 pathway	36
Inhibitory immune checkpoints suppress the surveillance of senescent cells promoting their accumulation with aging and in age-related diseases	33
The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cell	32
Arnold Mitnitski: mathematician who pioneered a new understanding of frailty (1944 – 2021)	28
Prematurely aging female mice improve their behavioural response, immunity, redox state, and lifespan after a short social interaction with non-prematurely aging mice	25
Simultaneous activation of the hydrogen sulfide biosynthesis genes (CBS and CSE) induces sex-specific geroprotective effects in Drosophila melanogaster	23
Long-term sulforaphane-treatment restores redox homeostasis and prevents cognitive decline in middleaged female and male rats, but cannot revert previous damage in old animals	23
Renal aging and mitochondrial quality control	23
Inflammaging in domestic dogs: basal level concentrations of IL-6, IL-1β, and TNF-α in serum of healthy dogs of different body sizes and ages	22
The potential use of nanozyme in aging and age‐related diseases	21
An AMP Kinase-pathway dependent integrated stress response regulates ageing and longevity	21
The SGLT2 inhibitor empagliflozin inhibits skeletal muscle fibrosis in naturally aging male mice through the AMPKα/MMP9/TGF-β1/Smad pathway	17
Mapping sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential?	17
Senescence of bone marrow mesenchymal stem cells in Wistar male rats receiving normal chow/high-calorie diets with/without vitamin D	17
Correlative links between natural radiation and life expectancy in the US population	16
Alexey Olovnikov: theoretical biology beyond the margins	15
Age and dietary restriction modulate mitochondrial quality in quadriceps femoris muscle of male mice	15
Immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older residents of a long-term care facility: relation with age, frailty and prior infection status	14
Aging through the lens of mitochondrial DNA mutations and inheritance paradoxes	14
Cell-type specific and differential expression of LINC-RSAS long noncoding RNA declines in the testes during ageing of the rat	14
Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies	14
Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies	14
Mitochondria and telomeres: hand in glove	14
Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats	14

Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders	13
Aberrant telomeric structures and serum markers of telomere dysfunction in healthy aging: a preliminary study	13
Low-molecular-weight heparin ameliorates intestinal barrier dysfunction in aged male rats via protection of tight junction proteins	13
Level-dependent effects of predation stress on prey development, lifespan and reproduction in mites	12
Forkhead box P1 transcriptionally activates IGF-1 to lighten ox-LDL-induced endothelial cellular senescence by inactivating NLRP3 inflammasome	12
CeO2 nanoparticles improve prooxidant/antioxidant balance, life quality and survival of old male rats	12
Correction: Empaglifozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress	12
Melatonin-related signaling pathways and their regulatory effects in aging organisms	12
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders	11
Directionality theory and mortality patterns across the primate lineage	11
Beyond balance: the impact of adult sex ratios on reproduction and longevity in Zophobas morio rearing	10
Association of serum metabolites with frailty phenotype and its components: a cross-sectional case–control study	10
Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach	10
GDF-15 as a proxy for epigenetic aging: associations with biological age markers, and physical function	10
The potential link between the development of Alzheimer’s disease and osteoporosis	9
“Development of gerontology would be more effective under governmental support”: an interview with Vladimir N. Anisimov	9
Age-dependent and modality-specific changes in the phenotypic markers Nav1.8, ASIC3, P2X3 and TRPM8 in male rat primary sensory neurons during healthy aging	9
The mitochondrial and cytoplasmic superoxide anion imbalance trigger the expression of certain cellular aging markers in HaCaT keratinocytes	8
Ufuk Çakatay (editor): Redox Signaling and Biomarkers in Ageing	8
Network analysis in aged C. elegans reveals candidate regulatory genes of ageing	8
Rooibos tea—in the cross fire of ROS, mitochondrial dysfunction and loss of proteostasis—positioned for healthy aging	8
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration	8
Identification of Isthmin1 in the small annual fish, Nothobranchius guentheri, as a novel biomarker of aging and its potential rejuvenation activity	8
Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster	8
Associations between dietary carotenoid and biological age acceleration: insights from NHANES 2009–2018	7
The potential longevity-promoting hypoxic-hypercapnic environment as a measure for radioprotection	7
Swimming exercise with l-arginine coated nanoparticles supplementation upregulated HAND2 and TBX5 expression in the cardiomyocytes of aging male rats	7
High stability of blood parameters during mouse lifespan: sex-specific effects of every-other-day fasting	7
Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential skin rejuvenation in male mice	7
Insights on the role of l-lactate as a signaling molecule in skin aging	7
Predation stress experienced as immature mites extends their lifespan	7
Geroprotective potential of genetic and pharmacological interventions to endogenous hydrogen sulfide synthesis in Drosophila melanogaster	7
Roles of genistein in learning and memory during aging and neurological disorders	6
Ribose-induced advanced glycation end products reduce the lifespan in Drosophila melanogaster by changing the redox state and down-regulating the Sirtuin genes	6
Proteostasis networks in aging: novel insights from text-mining approaches	6
Long-term dietary restriction ameliorates ageing-related renal fibrosis in male mice by normalizing mitochondrial functions and autophagy	6
COVID-19 detection in CT and CXR images using deep learning models	6
The protein cargo of extracellular vesicles correlates with the epigenetic aging clock of exercise sensitive DNAmFitAge	6
The seesaw of diet restriction and lifespan: lessons from Drosophila studies	6
Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model	6
The effect of three types of water-based training protocols on thymus atrophy and specific indicators of cellular immune senescence in aged male rats	6
Middle aged turn point in parameters of oxidative stress and glucose catabolism in mouse cerebellum during lifespan: minor effects of every-other-day fasting	6
Linking telomere dynamics to evolution, life history and environmental change: perspectives, predictions and problems	6
Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster	6
IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway	5
Piperine improves the health span of Drosophila melanogaster with age- and sex-specific effect	5
A novel rat model of sarcopenic obesity based on aging and high-fat diet consumption	5
Hormesis is an evolutionary expectation: implications for aging	5
The influence of biological sex in human skeletal muscle transcriptome during ageing	5
Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes	5

2,4-Dinitrophenol is toxic on a low caloric diet but extends lifespan of Drosophila melanogaster on nutrient-rich diets without an impact on metabolism	5
T-cell lymphocytes’ aging clock: telomeres, telomerase and aging	5
Application potential of senolytics in clinical treatment	5
RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells	5
Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex	5
Investigating cognitive impairments and hippocampal proteome alterations in aged male rats with TAA-Induced minimal hepatic encephalopathy	5
Sustained exposure to high glucose induces differential expression of cellular senescence markers in murine macrophages but impairs immunosurveillance response to senescent cells secretome	5
Aging disrupts the temporal organization of antioxidant defenses in the heart of male rats and phase shifts circadian rhythms of systolic blood pressure	4
A novel (−)-(2S)-7,4′-dihydroxyflavanone compound for treating age-related diabetes mellitus through immunoinformatics-guided activation of CISD3	4
The role of phagocytic cells in aging: insights from vertebrate and invertebrate models	4
Empagliflozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress	4
Dysbiosis and fecal microbiota transplant: Contemplating progress in health, neurodegeneration and longevity	4
Metabolic and physical function are improved with lifelong 15% calorie restriction in aging male mice	4
Influence of α-lipoic acid on longevity and stress resistance in Drosophila melanogaster fed with a high-fat diet	4
Chrysin mitigates neuronal apoptosis and impaired hippocampal neurogenesis in male rats subjected to D-galactose-induced brain aging	4
GDF15/MIC-1: a stress-induced immunosuppressive factor which promotes the aging process	4
Dietary intake of GDF11 delays the onset of several biomarkers of aging in male mice through anti-oxidant system via Smad2/3 pathway	4
Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components	4
Age-related decline in the expression of BRG1, ATM and ATR are partially reversed by dietary restriction in the livers of female mice	4
Geroprotective effects of GdVO4:Eu3 + nanoparticles, metformin and calorie restriction in male rats with accelerated aging induced by overnutrition in early postnatal ontogenesis	4
Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease	4
Age, cancer, and the dual burden of cancer and doxorubicin in skeletal muscle wasting in female rats: which one to blame?	3
Alexander Vaiserman (1957–2021)	3
Age-dependent effect of continuous ‘artificial light at night’ on circadian rhythm in male rats: neuroprotective role of melatonin	3
Production and scavenging of reactive oxygen species both affect reproductive success in male and female Drosophila melanogaster	3
Upregulation of LXRβ/ABCA1 pathway alleviates cochlear hair cell senescence of C57BL/6 J mice via reducing lipid droplet accumulation	3
AcidAGE: a biological age determination neural network based on urine organic acids	3
Aging impairs recovery from stress-induced depression in male rats possibly by alteration of microRNA-101 expression and Rac1/RhoA pathway in the prefrontal cortex	3
Pax6 affects Ras-Raf-ERK1/2 in mouse aging brain	3
Differential effects of aging on hippocampal ultrastructure in male vs. female rats	3
Editorial note for special issue on ‘dietary interventions for healthy ageing and longevity’	3
Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases	3
Retraction Note to: Carbohydrate-restricted diet promotes skin senescence in senescence-accelerated prone mice	3
Correction: Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease	3
A CRISPR base editing approach for the functional assessment of telomere biology disorder-related genes in human health and aging	3
New life expectancy forecasts are too optimistic	3
Telomeres in health and longevity: special issue in memory of Alexey Olovnikov	3
Common factors among three types of cells aged in mice	3
Non-coding RNAs in photoaging-related mechanisms: a new paradigm in skin health	3
Mitochondria-targeted senotherapeutic interventions	2
Lipids: biomarkers of healthy aging	2
How soon do metabolic alterations and oxidative distress precede the reduction of muscle mass and strength in Wistar rats in aging process?	2
Measuring healthy ageing: current and future tools	2
Revealing the molecular links between coronary heart disease and cognitive impairment: the role of aging-related genes and therapeutic potential of stellate ganglion block	2
The opposite aging effect to single cell transcriptome profile among cell subsets	2
The role of NAD and NAD precursors on longevity and lifespan modulation in the budding yeast, Saccharomyces cerevisiae	2
Analysis of the relationship between age-related erythrocyte dysfunction and fatigue	2
Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes	2
An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law	2
Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging	2
Enhancing the human health and lifespan: a targeted strategy emphasizing statins	2
Screening the active ingredients of plants via molecular docking technology and evaluating their ability to reduce skin photoaging	2
The impact of social partners: investigating mixed-strain housing effects on aging in female mice	2
Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions	2
Signaling mechanisms underlying lymphatic vessel dysfunction in skin aging and possible anti-aging strategies	2
Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function	2
A comprehensive model for the biochemistry of ageing, senescence and longevity	2
Redox signaling and modulation in ageing	2
Intracellular cytokines in peritoneal leukocytes relate to lifespan in aging and long-lived female mice	2
The potential of flavonoids to mitigate cellular senescence in cardiovascular disease	2
Invariances in relations between aging, exposure to external hazards, and mortality reflected in life table aging rate (LAR) patterns examined through the lens of generalized Gompertz–Makeham law	2
Dietary intervention with Tinospora cordifolia improved aging-related decline in locomotor coordination and cerebellar cell survival and plasticity in female rats	2
Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology	1
Marital and living status and biological ageing trajectories: a longitudinal cohort study with a 20-year follow-up	1
Role of a small GTPase Cdc42 in aging and age-related diseases	1
Correction to: Covid-19 and the next outbreak: decreasing frailty by using mild stress?	1
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies	1
The evolution of ageing: classic theories and emerging ideas	1
Immunoinformatic-based drug design utilizing hesperetin to target CISD2 activation for liver aging in humans	1
Anti-SASP and anti-inflammatory activity of resveratrol, curcumin and β-caryophyllene association on human endothelial and monocytic cells	1
Restricting the level of the proteins essential for the regulation of the initiation step of replication extends the chronological lifespan and reproductive potential in budding yeast	1
Compensation effect of mortality is a challenge to substantial lifespan extension of humans	1
Fisetin, a potential skin rejuvenation drug that eliminates senescent cells in the dermis	1
Estrogen receptor alpha mediates 17β-estradiol, up-regulates autophagy and alleviates hydrogen peroxide-induced vascular senescence	1
Correction to: The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders	1
Correction to: Estrogen receptor alpha mediates 17β-estradiol, up-regulates autophagy and alleviates hydrogen peroxide-induced vascular senescence	1
Targeting Wnt signaling pathway by polyphenols: implication for aging and age-related diseases	1
Oxidative stress-induced gene expression changes in prostate epithelial cells in vitro reveal a robust signature of normal prostatic senescence and aging	1
The impact of mosaic loss of the Y chromosome (mLOY) in men of advanced age	1
Chromosome ends and the theory of marginotomy: implications for reproduction	1

Oxygen transport across the lifespan of male Sprague Dawley rats	1
Coniferaldehyde activates autophagy and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans via par-4/aak-2/skn-1 pathway	1
The dichotomic role of cytokines in aging	1
Isotschimgine promotes lifespan, healthspan and neuroprotection of Caenorhabditis elegans via the activation of nuclear hormone receptors	1
Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans	1
Neglecting larval rearing conditions in Drosophila melanogaster can negatively impact research on ageing	1
Brown adipose tissue: a potential target for aging interventions and healthy longevity	1
Inhibition of mTOR prevents glucotoxicity-mediated increase of SA-beta-gal, p16INK4a, and insulin hypersecretion, without restoring electrical features of mouse pancreatic islets	1