OOIR: Observatory of International Research

Papers

(The median citation count of Biogerontology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Aging and age‐related diseases: from mechanisms to therapeutic strategies	260
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies	36
COVID-19 detection in CT and CXR images using deep learning models	36
Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders	35
Mitochondria-targeted senotherapeutic interventions	33
Seven knowledge gaps in modern biogerontology	32
Biochemical, structural and physical changes in aging human skin, and their relationship	28
Evidence from two cohorts for the frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems	26
Male sex hormones, aging, and inflammation	25
Daily ingestion of Akkermansia mucciniphila for one month promotes healthy aging and increases lifespan in old female mice	23
Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology	23
Anti-SASP and anti-inflammatory activity of resveratrol, curcumin and β-caryophyllene association on human endothelial and monocytic cells	23
Lipids: biomarkers of healthy aging	22
Mapping sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential?	21
A collective analysis of lifespan-extending compounds in diverse model organisms, and of species whose lifespan can be extended the most by the application of compounds	20
The greatest risk factor for the leading cause of death is ignored	19
Astaxanthin protects oxidative stress mediated DNA damage and enhances longevity in Saccharomyces cerevisiae	18
Immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older residents of a long-term care facility: relation with age, frailty and prior infection status	17
Alterations in hippocampal mitochondrial dynamics are associated with neurodegeneration and recognition memory decline in old male mice	17
Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster	17
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders	16
Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies	15
Green tea EGCG effectively alleviates experimental colitis in middle-aged male mice by attenuating multiple aspects of oxi-inflammatory stress and cell cycle deregulation	14
Targeting Wnt signaling pathway by polyphenols: implication for aging and age-related diseases	14
Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans	14

Enhancing health span: muscle stem cells and hormesis	14
Contribution of senescent and reactive astrocytes on central nervous system inflammaging	14
Role of a small GTPase Cdc42 in aging and age-related diseases	14
Analysis of longevity in Chordata identifies species with exceptional longevity among taxa and points to the evolution of longer lifespans	14
Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes	13
Inhibition of mTOR decreases insoluble proteins burden by reducing translation in C. elegans	13
Identification of Isthmin1 in the small annual fish, Nothobranchius guentheri, as a novel biomarker of aging and its potential rejuvenation activity	13
Tracing skin aging process: a mini- review of in vitro approaches	13
Melatonin-related signaling pathways and their regulatory effects in aging organisms	13
Geroscience: the need to address some issues	12
Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex	12
Sarcopenia versus cancer cachexia: the muscle wasting continuum in healthy and diseased aging	12
Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components	12
An essay on the nominal vs. real definitions of aging	11
G protein-coupled receptors that influence lifespan of human and animal models	11
Non-coding RNAs in photoaging-related mechanisms: a new paradigm in skin health	11
Redox signaling and modulation in ageing	10
The role of NAD and NAD precursors on longevity and lifespan modulation in the budding yeast, Saccharomyces cerevisiae	10
The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1	10
Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function	10
SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway	9
Gastrointestinal redox homeostasis in ageing	9
Aging disrupts the temporal organization of antioxidant defenses in the heart of male rats and phase shifts circadian rhythms of systolic blood pressure	9
Dietary intake of microplastics impairs digestive performance, induces hepatic dysfunction, and shortens lifespan in the annual fish Nothobranchius guentheri	9
Age-dependent effect of continuous ‘artificial light at night’ on circadian rhythm in male rats: neuroprotective role of melatonin	8
Geroprotective potential of genetic and pharmacological interventions to endogenous hydrogen sulfide synthesis in Drosophila melanogaster	8
Ginseng volatile oil prolongs the lifespan and healthspan of Caenorhabditis elegans	8
Empagliflozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress	8
Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions	8
Insights on the role of l-lactate as a signaling molecule in skin aging	8
Tackling cellular senescence by targeting miRNAs	8
3-Bromopyruvate, a caloric restriction mimetic, exerts a mitohormetic effect to provide neuroprotection through activation of autophagy in rats during aging	7
Production and scavenging of reactive oxygen species both affect reproductive success in male and female Drosophila melanogaster	7
Aging adipose tissue, insulin resistance, and type 2 diabetes	7
Hormesis is an evolutionary expectation: implications for aging	7
Dietary intake of diosgenin delays aging of male fish Nothobranchius guentheri through modulation of multiple pathways that play prominent roles in ROS production	7
Dietary intervention with Tinospora cordifolia improved aging-related decline in locomotor coordination and cerebellar cell survival and plasticity in female rats	7
Application of lipidomics strategy to explore aging-related biomarkers and potential anti-aging mechanisms of ginseng	6
Exploring the fuzzy border between senolytics and senomorphics with chemoinformatics and systems pharmacology	6
Hypertension and cellular senescence	6
Measuring healthy ageing: current and future tools	6
No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging	6
Telomeres, cellular senescence, and aging: past and future	6
Dynamics of redox signaling in aging via autophagy, inflammation, and senescence	6
An evaluation of aging measures: from biomarkers to clocks	6
Dietary intake of GDF11 delays the onset of several biomarkers of aging in male mice through anti-oxidant system via Smad2/3 pathway	6
CeO2 nanoparticles improve prooxidant/antioxidant balance, life quality and survival of old male rats	6
Age-related differences in response to plasma exchange in male rat liver tissues: insights from histopathological and machine-learning assisted spectrochemical analyses	6
Lack of age-related respiratory changes in Daphnia	6
Dietary interventions and molecular mechanisms for healthy musculoskeletal aging	6

Background radiation impacts human longevity and cancer mortality: reconsidering the linear no-threshold paradigm	6
IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway	6
Alternate day fasting and time-restricted feeding may confer similar neuroprotective effects during aging in male rats	5
Signaling mechanisms underlying lymphatic vessel dysfunction in skin aging and possible anti-aging strategies	5
Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease	5
Overexpression of a single ORF can extend chronological lifespan in yeast if retrograde signaling and stress response are stimulated	5
Alterations in bone metabolites with age in C57BL/6 mice model	5
Triiodothyronine (T3) enhances lifespan and protects against oxidative stress via activation of Klotho in Caenorhabditis elegans	5
Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases	5
Prematurely aging female mice improve their behavioural response, immunity, redox state, and lifespan after a short social interaction with non-prematurely aging mice	5
Lipid metabolism and ageing in Caenorhabditis elegans: a complex interplay	5
Responsible biology, aging populations and the 50th anniversary of the “War on Cancer”	5
Lipofuscin, amyloids, and lipid peroxidation as potential markers of aging in Daphnia	5
Metabolic and physical function are improved with lifelong 15% calorie restriction in aging male mice	5
Aging-related changes in metabolic indicators in female rats and their management with Tinospora cordifolia	5
The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cell	4
SIRT4 in ageing	4
Fisetin, a potential skin rejuvenation drug that eliminates senescent cells in the dermis	4
Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes	4
High stability of blood parameters during mouse lifespan: sex-specific effects of every-other-day fasting	4
A mild heat stress increases resistance to heat of dFOXO Drosophila melanogaster mutants but less in wild-type flies	4
Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells	4
T-cell lymphocytes’ aging clock: telomeres, telomerase and aging	4
Long-term detraining reverses the improvement of lifelong exercise on skeletal muscle ferroptosis and inflammation in aging rats: fiber-type dependence of the Keap1/Nrf2 pathway	4
Aging and short-term calorie restriction differently affect the cardiac and skeletal muscle expression of genes regulating energy substrate utilization in male rats	4
Sex-related differences in behavioural markers in adult mice for the prediction of lifespan	4
Evaluation of potential aging biomarkers in healthy individuals: telomerase, AGEs, GDF11/15, sirtuin 1, NAD+, NLRP3, DNA/RNA damage, and klotho	4
Middle aged turn point in parameters of oxidative stress and glucose catabolism in mouse cerebellum during lifespan: minor effects of every-other-day fasting	4
Telomere length and cancer risk: finding Goldilocks	3
Early-onset caloric restriction alleviates ageing-associated steatohepatitis in male mice via restoring mitochondrial homeostasis	3
The role of transposable elements in aging and cancer	3
Sustained exposure to high glucose induces differential expression of cellular senescence markers in murine macrophages but impairs immunosurveillance response to senescent cells secretome	3
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration	3
Inflammaging in domestic dogs: basal level concentrations of IL-6, IL-1β, and TNF-α in serum of healthy dogs of different body sizes and ages	3
Aging-accelerated differential production and aggregation of STAT3 protein in neuronal cells and neural stem cells in the male mouse spinal cord	3
Hormetic association between perceived stress and human epigenetic aging based on resilience capacity	3
An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law	3
A novel rat model of sarcopenic obesity based on aging and high-fat diet consumption	3
The potential use of nanozyme in aging and age‐related diseases	3
Senescence of bone marrow mesenchymal stem cells in Wistar male rats receiving normal chow/high-calorie diets with/without vitamin D	3
Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study	3
The nexus between peroxisome abundance and chronological ageing in Saccharomyces cerevisiae	3
Estrogen receptor alpha mediates 17β-estradiol, up-regulates autophagy and alleviates hydrogen peroxide-induced vascular senescence	3
The seesaw of diet restriction and lifespan: lessons from Drosophila studies	3
An AMP Kinase-pathway dependent integrated stress response regulates ageing and longevity	3