Mini-Reviews in Medicinal Chemistry

Article	Citations
The Roles of Flavonols/Flavonoids in Neurodegeneration and Neuroinflammation	104
Biological Nanofactories: Using Living Forms for Metal Nanoparticle Synthesis	93
Anticancer Potential of Coumarin and its Derivatives	81
From Antibacterial to Antitumour Agents: A Brief Review on The Chemical and Medicinal Aspects of Sulfonamides	69
Antiviral Activities of Pyridine Fused and Pyridine Containing Heterocycles, A Review (from 2000 to 2020)	53
Resistance to Intervention: Paclitaxel in Breast Cancer	47
Current and Advanced Nanomaterials in Dentistry as Regeneration Agents: An Update	46
Ferulic Acid and Cardiovascular Health: Therapeutic and Preventive Potential	43
Recent Applications of Azo Dyes: A Paradigm Shift from Medicinal Chemistry to Biomedical Sciences	41
The Role of EGCG in Breast Cancer Prevention and Therapy.	40
Recent Progress in Anticancer Agents Incorporating Pyrazole Scaffold	40
Herbal Drugs and Natural Products in the light of Nanotechnology and Nanomedicine for Developing Drug Formulations	40
Pharmacological Actions and Underlying Mechanisms of Catechin: A Review	39
Novel Hybrid Molecules Based on triazole-β-lactam as Potential Biological Agents	38
Plumbagin: A Potential Anti-cancer Compound	37
Osthole: A Multifunctional Natural Compound with Potential Anticancer, Antioxidant and Anti-inflammatory Activities	35
A Review on Anticancer Activities of Thiophene and Its Analogs	35
Psoralen: A Biologically Important Coumarin with Emerging Applications	33
Fenugreek Cultivation with Emphasis on Historical Aspects and its uses in Traditional Medicine and Modern Pharmaceutical Science	33
Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives	31
Advancement in Pharmacological Activities of Benzothiazole and its Derivatives: An Up to Date Review	31
Recent Advancements on Benzimidazole: A Versatile Scaffold in Medicinal Chemistry	30
Isatin: A Scaffold with Immense Biodiversity	29
Zinc Poisoning - Symptoms, Causes, Treatments	29
A Recent Appraisal of Artificial Intelligence and In Silico ADMET Prediction in the Early Stages of Drug Discovery	29

Advances in Anti-inflammatory Activity, Mechanism and Therapeutic Application of Ursolic Acid	28
A Panoramic Review of Benzimidazole Derivatives and their Potential Biological Activity	28
Imidazole Derivatives and their Antibacterial Activity – a Mini-Review	27
Antioxidant, Anti-inflammatory, Antibacterial, and Analgesic Activities and Mechanisms of Quinolines, Indoles and Related Derivatives	27
Thymoquinone: A Review on its Pharmacological Importance, and its Association with Oxidative Stress, COVID-19, and Radiotherapy	26
Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi	26
Quinoline: An Attractive Scaffold in Drug Design	26
Curcumin: An Insight into Molecular Pathways Involved in Anticancer Activity	26
Herbal Extracts with Antifungal Activity against Candida albicans: A Systematic Review	25
Recent Developments of Target Based Coumarin Derivatives as Potential Anticancer Agents	25
Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity	24
Update on Acrylic Resins Used in Dentistry	24
Structure-Activity Relationships of Natural and Synthetic Indole-Derived Scaffolds as α-Glucosidase Inhibitors: A Mini-Review	23
An Updated Review of Various Medicinal Applications of p-Co umaric Acid: From Antioxidative and Anti-Inflammatory Properties to Effects on Cell Cycle and Proliferation	23
Antioxidant Activity of 1,2,4-Triazole and its Derivatives: A Mini-Review	23
Advances in Ethnobotany, Synthetic Phytochemistry and Pharmacology of Endangered Herb Picrorhiza kurroa (Kutki): A Comprehensive Review (2010-2020)	22
An Updated Review of Secondary Metabolites from Marine Fungi	22
Therapeutic Journey of Andrographis paniculata (Burm.f.) Nees from Natural to Synthetic and Nanoformulations	22
Medicinal Plant Centipeda Minima: A Resource of Bioactive Compounds	22
The Advances on the Protective Effects of Ginsenosides on Myocardial Ischemia and Ischemia-Reperfusion Injury	22
Antimicrobial Properties of Mandelic Acid, Gallic Acid and their Derivatives	22
Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity	21
Chromenes - A Novel Class of Heterocyclic Compounds: Recent Advancements and Future Directions	21
Emerging Role of Terpenoids for the Treatment of Cancer: A Review	20
Thiosemicarbazides: Updates on Antivirals Strategy	20
Diverse Thiophenes as Scaffolds in Anti-cancer Drug Development: A Concise Review	19
Structure and Activity of Pentacyclic Triterpenes Codrugs. A Review	19
Pyridine Moiety: An Insight into Recent Advances in the Treatment of Cancer	19
Current Insights into the Chemistry and Antitubercular Potential of Benzimidazole and Imidazole Derivatives	18
Virtual Screening of Natural Products Database	18
Diversified Synthetic Pathway of 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules	18
Medicinally Privileged Sultams: Synthesis and Mechanism of Action	18
Adhatoda vasica (Nees.): A Review on its Botany, Traditional uses, Phytochemistry, Pharmacological Activities and Toxicity	17
Marine Sponge-Associated Fungi as Potential Novel Bioactive Natural Product Sources for Drug Discovery: A Review	17
Isatin Hybrids and Their Pharmacological Investigations	17
Current Perspective of Synthesis of Medicinally Relevant Benzothiazole based Molecules: Potential for Antimicrobial and Anti-Inflammatory Activities	17
Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor- Kappa B (NF-kB) Inhibitors	17
Hypericin Ameliorates Maternal Separation-Induced Cognitive Deficits and Hippocampal Inflammation in Rats	17
Effective Pharmacophore for CDC25 Phosphatases Enzyme Inhibitors: Newly Synthesized Bromothiazolopyrimidine Derivatives	16
Glitazones, PPAR-γ and Neuroprotection	16
Quinoxaline: A Chemical Moiety with Spectrum of Interesting Biological Activities	16
Association of Micro RNA and Postoperative Cognitive Dysfunction: A Review	16
1,3,4-Oxadiazole Containing Compounds As Therapeutic Targets For Cancer Therapy	16
Inhibitors of Cholinesterases in Pharmacology: the Current Trends	16
The Chemistry of Triazine Isomers: Structures, Reactions, Synthesis and Applications	16
GSK-3β and its Inhibitors in Alzheimer's Disease: A Recent Update	16
Multitarget Directed Ligand Approaches for Alzheimer’s Disease: A Comprehensive Review	16
The Role of 3'UTR of RNA Viruses on mRNA Stability and Translation Enhancement	15
Irreversible Kinase Inhibitors Targeting Cysteine Residues and their Applications in Cancer Therapy	15
Cyclopropyl Scaffold: A Generalist for Marketed Drugs	15

A Comprehensive Review on Therapeutic Applications of Ferulic Acid and its Novel Analogues: A Brief Literature	15
Advances on the Anti-Inflammatory Activity of Oleanolic Acid and Derivatives	15
Moringa Oleifera: A Review of Its Occurrence, Pharmacological Importance and Oxidative Stress	15
A Comprehensive Review on Linum usitatissimum Medicinal Plant: Its Phytochemistry, Pharmacology, and Ethnomedicinal Uses	15
Anti-aging Natural Compounds and their Role in the Regulation of Metabolic Pathways Leading to Longevity	15
Ferroptosis Inhibitors as Potential New Therapeutic Targets for Cardiovascular Disease	14
Pharmacological Efficacy and Safety of Glycyrrhiza glabra in the Treatment of Respiratory Tract Infections	14
Advances in Research on the Preparation and Biological Activity of Maslinic Acid	14
Recent Advances in the Development of Fatty Acid Synthase Inhibitors as Anticancer Agents	14
Astaxanthin and Nrf2 Signaling Pathway: A Novel Target for New Therapeutic Approaches	14
Andrographolide: Synthetic Methods and Biological Activities	14
Probiotics and their Beneficial Health Effects	14
A Systematic Review of Current Progresses in the Nucleic Acid-Based Therapies for Neurodegeneration with Implications for Alzheimer’s Disease	14
A Review on Vitamin E Natural Analogues and on the Design of Synthetic Vitamin E Derivatives as Cytoprotective Agents	13
Inhibition of S-protein RBD and hACE2 Interaction for Control of SARSCoV- 2 Infection (COVID-19)	13
Xanthone: Potential Acetylcholinesterase Inhibitor for Alzheimer's Disease Treatment	13
Therapeutic Journey and Recent Advances in the Synthesis of Coumarin Derivatives	13
A Review on Classification and Biological Activities of Alkaloids from the Genus Zanthoxylum Species	13
Biological Role of AKT and Regulation of AKT Signaling Pathway by Thymoquinone: Perspectives in Cancer Therapeutics	13
Novel Mitochondria-targeted Drugs for Cancer Therapy	13
Association of Zinc and Copper Status with Cardiovascular Diseases and their Assessment Methods: A Review Study	13
The Zinc-dependent HDACs: Non-histone Substrates and Catalytic Deacylation Beyond Deacetylation	13
Phytotherapy for Wound Healing: The Most Important Herbal Plants in Wound Healing Based on Iranian Ethnobotanical Documents	13
Medicinal and Biological Significance of Phenoxazine Derivatives	12
Brassica oleracea var. capitata f. alba: A Review on its Botany, Traditional uses, Phytochemistry and Pharmacological Activities	12
Thiophene and Its Analogs as Prospective Antioxidant Agents: A Retrospective Study	12
Recent Progress of Bioactivities, Mechanisms of Action, Total Synthesis, Structural Modifications and Structure-activity Relationships of Indole Derivatives: A Review	12
An Insight in Pathophysiological Mechanism of Alzheimer’s Disease and its Management Using Plant Natural Products	12
A Review of the Effects of Gold, Silver, Selenium, and Zinc Nanoparticles on Diabetes Mellitus in Murine Models	12
Curcumin as a Natural Modulator of B Lymphocytes: Evidence from In Vitro and In Vivo Studies	12
Advances in Pyrazole Based Scaffold as Cyclin-dependent Kinase 2 Inhibitors for the Treatment of Cancer	12
Development of Natural Bioactive Alkaloids: Anticancer Perspective	12
Multi-Target Drug Design of Anti-Alzheimer’s Disease based on Tacrine	12
p-Benzoquinone as a Privileged Scaffold of Pharmacological Significance: A Review	12
An Overview of Biosynthetic Pathway and Therapeutic Potential of Rutin	12
1,8-Naphthyridine Derivatives: A Privileged Scaffold for Versatile Biological Activities	12
Role of Cathepsin B in Cancer Progression: A Potential Target for Coordination Compounds	12
Recent Updates on Free Fatty Acid Receptor 1 (GPR-40) Agonists for the Treatment of Type 2 Diabetes Mellitus	11
Evodiamine: A Privileged Structure with Broad-ranging Biological Activities	11
Research Progress in Alpha-fetoprotein-induced Immunosuppression of Liver Cancer	11
CRISPR-Cas9 Genome Engineering: Trends in Medicine and Health	11
Novel Niacin Receptor Agonists: A Promising Strategy for the Treatment of Dyslipidemia	11
The Research Progress of DPP-4 Inhibitors	11
Osthole: Synthesis, Structural Modifications, and Biological Properties	11
Current Perspectives on Paclitaxel: Focus on Its Production, Delivery and Combination Therapy	11
Modulation of Calcium Signaling in Glioblastoma Multiforme: A Therapeutic Promise for Natural Products	11
The Importance of Rhodanine Scaffold in Medicinal Chemistry: A Comprehensive Overview	11
Interactions of Dehydrogenase Enzymes with Nanoparticles Industrial and Medical Applications and Challenges: Mini-review	11
Chitosan: Applications in Drug Delivery System	11
Human Galectin-1 in Multiple Cancers: A Privileged Molecular Target in Oncology	11
Natural Terpenoids as Neuroinflammatory Inhibitors in LPS-stimulated BV-2 Microglia	11
Regulation of Catechins in Uric Acid Metabolism Disorder Related Human Diseases	11
Therapeutic Potential of Thiophene Compounds: A Mini-Review	11
The Recent Development of Piperazine and Piperidine Derivatives as Antipsychotic Agents	11
The Potential Application of Novel Drug Delivery Systems for Phytopharmaceuticals and Natural Extracts – Current Status and Future Perspectives	11
Ultrasmall Europium, Gadolinium, and Dysprosium Oxide Nanoparticles: Polyol Synthesis, Properties, and Biomedical Imaging Applications	11
A Review on a Medicinal and Edible Plant: Aralia elata (Miq.) Seem.	11
Glycyrrhizin as a Potential Treatment for the Novel Coronavirus (COVID-19)	11
The Complex Roles of DNA Repair Pathways, Inhibitors, Hyperthermia, and Contact Inhibition in Cell Cycle Halts	11
Phytochemical Profiles and their Anti-inflammatory Responses Against Influenza from Traditional Chinese Medicine or Herbs	10
Anticancer Activity of Diosgenin and Its Semi-synthetic Derivatives: Role in Autophagy Mediated Cell Death and Induction of Apoptosis	10
The Quinazoline-Chalcone and Quinazolinone-Chalcone Hybrids: A Promising Combination for Biological Activity	10
Irisin and Energy Metabolism and the Role of Irisin on Metabolic Syndrome	10
Design, Synthesis, SAR Study, Antimicrobial and Anticancer Evaluation of Novel 2-Mercaptobenzimidazole Azomethine Derivatives	10
Applications of ROS-InducedZr-MOFs Platform in Multimodal Synergistic Therapy	10
A Review on the In Vitro Evaluation of the Anticholinesterase Activity Based on Ellman’s Method	10
Dehydroepiandrosterone (DHEA): Pharmacological Effects and Potential Therapeutic Application	10
A Short Review on Glucogallin and its Pharmacological Activities	10
Effectiveness of Azithromycin as Add-on Therapy in COVID-19 Management	10
G-Protein Coupled Receptors Involved in the Resolution of Inflammation: Ligands and Therapeutic Perspectives	10
Plant Polyphenols: Natural and Potent UV-Protective Agents for the Prevention and Treatment of Skin Disorders	10
An Elite Scaffold and a Wonderful Pharmacophore in Drug Discovery: Styrylquinoline	10
Recent Developments in Nano-Drug Delivery Systems Loaded by Phytochemicals for Wound Healing	10
Recent Update on the Anti-infective Potential of β-carboline Analogs	10
Mechanism of Action of Collagen and Epidermal Growth Factor: A Review on Theory and Research Methods	9
An Overview of the Synthetic Route to the Marketed Formulations of Pyrimidine: A Review	9
Heterocyclic Moieties as HDAC Inhibitors: Role in Cancer Therapeutics	9
A Review on Rotenoids: Purification, Characterization and its Biological Applications	9
Limonene and Perillyl Alcohol Derivatives: Synthesis and Anticancer Activity	9
Induction of Cancer Cell Death by Apigenin: A Review on Different Cell Death Pathways	9

Exploring Quinolone Scaffold: Unravelling the Chemistry of Anticancer Drug Design	9
Mediterranean Diet Polyphenols: Anthocyanins and Their Implications for Health	9
Discovery and Development of Antibacterial Agents: Fortuitous and Designed	9
Tannic Acid as a Green Cross-linker for Biomaterial Applications	9
Hybrid Quantum Mechanics/Molecular Mechanics (QM/MM) Simulation: A Tool for Structure-Based Drug Design and Discovery	9
PROTACs in Treatment of Cancer: A Review	9
Therapeutic Potential of Resveratrol in the Treatment of Glioma: Insights into its Regulatory Mechanisms	9
Appraisal of the Role of In silico Methods in Pyrazole Based Drug Design	9
Flavonoids: A Reservoir of Drugs from Nature	8
Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?	8
Genome-wide Core Proteome Analysis of Brucella melitensis Strains for Potential Drug Target Prediction	8
Therapeutic Potential of Superoxide Dismutase Fused with Cell- Penetrating Peptides in Oxidative Stress-Related Diseases	8
Roles of Cannabidiol in the Treatment and Prevention of Alzheimer’s Disease by Multi-target Actions	8
Biomedical Implications of Plant-based Principles as Antidepressants: Prospects for Novel Drug Development	8
Small-Molecule Drugs in Immunotherapy	8
A Comprehensive Review of Garcinia pedunculata Roxb. and its Therapeutic Potential	8
Biodegradable Polymers and their Applications: A Review	8
Antiviral Activity of Pyrimidine Containing Compounds: Patent Review	8
Fullerenes For Anticancer Drug Targeting: Teaching An Old Dog A New Trick	8
Rhein Derivatives, A Promising Pivot?	8
A Review: Discovering 1,3,4-oxadiazole and Chalcone Nucleus for Cytotoxicity / EGFR Inhibitory Anticancer Activity	8
Antiviral Compounds Based on Natural Astragalus polysaccharides (APS): Research and Foresight in the Strategies for Combating SARS-CoV-2 (COVID-19)	8
Biological Activities, Pharmacokinetics and Toxicity of Nootkatone: A Review	8
Current Progress in Biomedical Applications of Chitosan-Carbon Nanotube Nanocomposites: A Review	8
Bioactivity of Natural Polyphenols as Antiparasitic Agents and their Biochemical Targets	8
A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review	8
A Review on Recent Developments in the Anticancer Potential of Oleanolic Acid and its Analogs (2017-2020)	8
Tanshinones and their Derivatives: Heterocyclic Ring-Fused Diterpenes of Biological Interest	8
A Review on Structure-Activity Relationships of Glycyrrhetinic Acid Derivatives with Diverse Bioactivities	8
Nuclear Medicine Application of Pentixafor/Pentixather Targeting CXCR4 for Imaging and Therapy in Related Disease	8