Mini-Reviews in Medicinal Chemistry

Article	Citations
Parkinson’s Disease: A Review from Pathophysiology to Treatment	100
Biological Nanofactories: Using Living Forms for Metal Nanoparticle Synthesis	86
The Roles of Flavonols/Flavonoids in Neurodegeneration and Neuroinflammation	80
Potent Acetylcholinesterase Inhibitors: Potential Drugs for Alzheimer’s Disease	67
Anticancer Potential of Coumarin and its Derivatives	62
Thiosemicarbazones as Potent Anticancer Agents and their Modes of Action	62
Synthesis and Biological Activity of Hydrazones and Derivatives: A Review	61
Benzimidazole: A Milestone in the Field of Medicinal Chemistry	60
Natural Polysaccharides with Immunomodulatory Activities	54
From Antibacterial to Antitumour Agents: A Brief Review on The Chemical and Medicinal Aspects of Sulfonamides	44
Monoterpenes: Essential Oil Components with Valuable Features	39
Antiviral Activities of Pyridine Fused and Pyridine Containing Heterocycles, A Review (from 2000 to 2020)	37
Novel Hybrid Molecules Based on triazole-β-lactam as Potential Biological Agents	35
The Role of EGCG in Breast Cancer Prevention and Therapy.	33
Resistance to Intervention: Paclitaxel in Breast Cancer	32
Herbal Drugs and Natural Products in the light of Nanotechnology and Nanomedicine for Developing Drug Formulations	32
Recent Applications of Azo Dyes: A Paradigm Shift from Medicinal Chemistry to Biomedical Sciences	32
Ferulic Acid and Cardiovascular Health: Therapeutic and Preventive Potential	32
Medicinal Thiols: Current Status and New Perspectives	31
Osthole: A Multifunctional Natural Compound with Potential Anticancer, Antioxidant and Anti-inflammatory Activities	29
Plumbagin: A Potential Anti-cancer Compound	29
Fenugreek Cultivation with Emphasis on Historical Aspects and its uses in Traditional Medicine and Modern Pharmaceutical Science	29
Applications of Quantitative Structure-Activity Relationships (QSAR) based Virtual Screening in Drug Design: A Review	28
Recent Progress in Anticancer Agents Incorporating Pyrazole Scaffold	28
Current and Advanced Nanomaterials in Dentistry as Regeneration Agents: An Update	27

An Appraisal of Current Pharmacological Perspectives of Sesamol: A Review	27
Medicinal Plants in the Treatment of Peptic Ulcer Disease: A Review	27
An Insight into the Synthesis and SAR of 2,4-Thiazolidinediones (2,4-TZD) as Multifunctional Scaffold: A Review	26
Pharmacological Actions and Underlying Mechanisms of Catechin: A Review	25
Paeonol Derivatives and Pharmacological Activities: A Review of Recent Progress	25
Recent Advancements on Benzimidazole: A Versatile Scaffold in Medicinal Chemistry	25
Advancement in Pharmacological Activities of Benzothiazole and its Derivatives: An Up to Date Review	24
Molecular Mechanisms of the Action of Myricetin in Cancer	24
Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives	24
Psoralen: A Biologically Important Coumarin with Emerging Applications	24
Quinoline: An Attractive Scaffold in Drug Design	23
Recent Developments of Target Based Coumarin Derivatives as Potential Anticancer Agents	23
A Review on Anticancer Activities of Thiophene and Its Analogs	23
Lignans from Medicinal Plants and their Anticancer Effect	23
A Recent Appraisal of Artificial Intelligence and In Silico ADMET Prediction in the Early Stages of Drug Discovery	23
Isatin: A Scaffold with Immense Biodiversity	23
Imidazole Derivatives and their Antibacterial Activity – a Mini-Review	22
Traditional Uses, Therapeutic Effects and Recent Advances of Curcumin: A Mini-Review	22
A Panoramic Review of Benzimidazole Derivatives and their Potential Biological Activity	21
Advances in Anti-inflammatory Activity, Mechanism and Therapeutic Application of Ursolic Acid	21
Influence of Plant Bioactive Compounds on Intestinal Epithelial Barrier in Poultry	21
Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity	21
Anticancer and Antimicrobial Activities of Naproxen and Naproxen Derivatives	20
A Review on the Pharmacokinetic Properties of Naringin and Its Therapeutic Efficacies in Respiratory Diseases	20
Thymoquinone: A Review on its Pharmacological Importance, and its Association with Oxidative Stress, COVID-19, and Radiotherapy	20
New Development of Novel Berberine Derivatives against Bacteria	19
Zinc Poisoning - Symptoms, Causes, Treatments	19
Antioxidant, Anti-inflammatory, Antibacterial, and Analgesic Activities and Mechanisms of Quinolines, Indoles and Related Derivatives	19
First Synthesis for Bis-Spirothiazolidine Derivatives as a Novel Heterocyclic Framework and Their Biological Activity	18
Medicinal Plant Centipeda Minima: A Resource of Bioactive Compounds	18
Current Trends in Drug Delivery System of Curcumin and its Therapeutic Applications	18
Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity	18
Curcumin: An Insight into Molecular Pathways Involved in Anticancer Activity	18
An Updated Review of Secondary Metabolites from Marine Fungi	18
Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi	18
Structure-Activity Relationships of Natural and Synthetic Indole-Derived Scaffolds as α-Glucosidase Inhibitors: A Mini-Review	18
An Updated Review of Various Medicinal Applications of p-Co umaric Acid: From Antioxidative and Anti-Inflammatory Properties to Effects on Cell Cycle and Proliferation	18
The Advances on the Protective Effects of Ginsenosides on Myocardial Ischemia and Ischemia-Reperfusion Injury	17
Update on Acrylic Resins Used in Dentistry	17
The Application of the Combination of Monte Carlo Optimization Method based QSAR Modeling and Molecular Docking in Drug Design and Development	17
Thiosemicarbazides: Updates on Antivirals Strategy	17
Diversified Synthetic Pathway of 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules	17
Antimicrobial Properties of Mandelic Acid, Gallic Acid and their Derivatives	16
Hypericin Ameliorates Maternal Separation-Induced Cognitive Deficits and Hippocampal Inflammation in Rats	16
Inhibitors of Cholinesterases in Pharmacology: the Current Trends	16
Structure and Activity of Pentacyclic Triterpenes Codrugs. A Review	16
Synthesis and Biological Activity of Embelin and its Derivatives: An Overview	16
Isatin Hybrids and Their Pharmacological Investigations	16
Emerging Role of Terpenoids for the Treatment of Cancer: A Review	15
Therapeutic Journey of Andrographis paniculata (Burm.f.) Nees from Natural to Synthetic and Nanoformulations	15

1,3,4-Oxadiazole Containing Compounds As Therapeutic Targets For Cancer Therapy	15
Will Arsenic Trioxide Benefit Treatment of Solid Tumor by Nano- Encapsulation?	15
Association of Micro RNA and Postoperative Cognitive Dysfunction: A Review	15
The Chemistry of Triazine Isomers: Structures, Reactions, Synthesis and Applications	15
Antioxidant Activity of 1,2,4-Triazole and its Derivatives: A Mini-Review	15
Macrolactin Antibiotics: Amazing Natural Products	15
Recent Progress of Oridonin and Its Derivatives for the Treatment of Acute Myelogenous Leukemia	15
Current Insights into the Chemistry and Antitubercular Potential of Benzimidazole and Imidazole Derivatives	15
Herbal Extracts with Antifungal Activity against Candida albicans: A Systematic Review	15
A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies	14
Virtual Screening of Natural Products Database	14
Advances in Ethnobotany, Synthetic Phytochemistry and Pharmacology of Endangered Herb Picrorhiza kurroa (Kutki): A Comprehensive Review (2010-2020)	14
Pyridine Moiety: An Insight into Recent Advances in the Treatment of Cancer	14
Anti-aging Natural Compounds and their Role in the Regulation of Metabolic Pathways Leading to Longevity	14
Moringa Oleifera: A Review of Its Occurrence, Pharmacological Importance and Oxidative Stress	14
Marine Sponge-Associated Fungi as Potential Novel Bioactive Natural Product Sources for Drug Discovery: A Review	14
Cyclopropyl Scaffold: A Generalist for Marketed Drugs	13
Multitarget Directed Ligand Approaches for Alzheimer’s Disease: A Comprehensive Review	13
The Role of 3'UTR of RNA Viruses on mRNA Stability and Translation Enhancement	13
A Systematic Review of Current Progresses in the Nucleic Acid-Based Therapies for Neurodegeneration with Implications for Alzheimer’s Disease	13
Recent Advances in the Development of Fatty Acid Synthase Inhibitors as Anticancer Agents	12
Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery	12
Medicinally Privileged Sultams: Synthesis and Mechanism of Action	12
Irreversible Kinase Inhibitors Targeting Cysteine Residues and their Applications in Cancer Therapy	12
Advances on the Anti-Inflammatory Activity of Oleanolic Acid and Derivatives	12
Medicinal Potential of Heterocyclic Compounds from Diverse Natural Sources for the Management of Cancer	12
Anticancer Agents Based on Vulnerable Components in a Signalling Pathway	12
Pharmacokinetics-based Dose Management of 5-Fluorouracil Clinical Research in Advanced Colorectal Cancer Treatment	12
Chromenes - A Novel Class of Heterocyclic Compounds: Recent Advancements and Future Directions	12
1,8-Naphthyridine Derivatives: A Privileged Scaffold for Versatile Biological Activities	12
Synthesis, Cytotoxicity and Molecular Docking Simulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages	12
Pharmacological Efficacy and Safety of Glycyrrhiza glabra in the Treatment of Respiratory Tract Infections	12
Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor- Kappa B (NF-kB) Inhibitors	12
Carbazole Derivatives as Kinase-Targeting Inhibitors for Cancer Treatment	12
A Review of the Effects of Gold, Silver, Selenium, and Zinc Nanoparticles on Diabetes Mellitus in Murine Models	11
Diverse Thiophenes as Scaffolds in Anti-cancer Drug Development: A Concise Review	11
Novel Mitochondria-targeted Drugs for Cancer Therapy	11
Advances in Research on the Preparation and Biological Activity of Maslinic Acid	11
Ferroptosis Inhibitors as Potential New Therapeutic Targets for Cardiovascular Disease	11
Phytotherapy for Wound Healing: The Most Important Herbal Plants in Wound Healing Based on Iranian Ethnobotanical Documents	11
A Review on Classification and Biological Activities of Alkaloids from the Genus Zanthoxylum Species	11
The Importance of Rhodanine Scaffold in Medicinal Chemistry: A Comprehensive Overview	11
Andrographolide: Synthetic Methods and Biological Activities	11
Xanthone: Potential Acetylcholinesterase Inhibitor for Alzheimer's Disease Treatment	11
Adhatoda vasica (Nees.): A Review on its Botany, Traditional uses, Phytochemistry, Pharmacological Activities and Toxicity	11
Glitazones, PPAR-γ and Neuroprotection	11
Biological Role of AKT and Regulation of AKT Signaling Pathway by Thymoquinone: Perspectives in Cancer Therapeutics	11
Novel Niacin Receptor Agonists: A Promising Strategy for the Treatment of Dyslipidemia	11
Role of Cathepsin B in Cancer Progression: A Potential Target for Coordination Compounds	11
Development of Natural Bioactive Alkaloids: Anticancer Perspective	10
Aquaporins and Roles in Brain Health and Brain Injury	10
Therapeutic Journey and Recent Advances in the Synthesis of Coumarin Derivatives	10
A Review on Vitamin E Natural Analogues and on the Design of Synthetic Vitamin E Derivatives as Cytoprotective Agents	10
The Recent Development of Piperazine and Piperidine Derivatives as Antipsychotic Agents	10
Advances on the Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships of Cytisine Derivatives	10
Current Perspective of Synthesis of Medicinally Relevant Benzothiazole based Molecules: Potential for Antimicrobial and Anti-Inflammatory Activities	10
Micro-RNA and the Features of Metabolic Syndrome: A Narrative Review	10
Glycyrrhizin as a Potential Treatment for the Novel Coronavirus (COVID-19)	10
The QSAR Paradigm in Fragment-Based Drug Discovery: From the Virtual Generation of Target Inhibitors to Multi-Scale Modeling	10
The Quinazoline-Chalcone and Quinazolinone-Chalcone Hybrids: A Promising Combination for Biological Activity	10
Design, Synthesis, Molecular Docking Study and Anti-Hepatocellular Carcinoma Evaluation of New Bis-Triazolothiadiazines	10
Research Progress in Alpha-fetoprotein-induced Immunosuppression of Liver Cancer	10
The Zinc-dependent HDACs: Non-histone Substrates and Catalytic Deacylation Beyond Deacetylation	10
An Insight in Pathophysiological Mechanism of Alzheimer’s Disease and its Management Using Plant Natural Products	10
Design, Synthesis, SAR Study, Antimicrobial and Anticancer Evaluation of Novel 2-Mercaptobenzimidazole Azomethine Derivatives	10
p-Benzoquinone as a Privileged Scaffold of Pharmacological Significance: A Review	10
Regulation of Catechins in Uric Acid Metabolism Disorder Related Human Diseases	10
Modulation of Calcium Signaling in Glioblastoma Multiforme: A Therapeutic Promise for Natural Products	10
Association of Zinc and Copper Status with Cardiovascular Diseases and their Assessment Methods: A Review Study	10
Inhibition of S-protein RBD and hACE2 Interaction for Control of SARSCoV- 2 Infection (COVID-19)	10
Advances in Pyrazole Based Scaffold as Cyclin-dependent Kinase 2 Inhibitors for the Treatment of Cancer	10
Thiophene and Its Analogs as Prospective Antioxidant Agents: A Retrospective Study	9
CRISPR-Cas9 Genome Engineering: Trends in Medicine and Health	9
Assembly of Benzothiazine and Triazole in a Single Molecular Entity: Synthesis of -Oxicam Derived Novel Molecules as Potential Antibacterial/ Anti-cancer Agents	9
Quercetin-Amino Acid Conjugates are Promising Anti-Cancer Agents in Drug Discovery Projects	9
Multi-Target Drug Design of Anti-Alzheimer’s Disease based on Tacrine	9
Coumarin-based Scaffold as α-glucosidase Inhibitory Activity: Implication for the Development of Potent Antidiabetic Agents	9
Advances in BPA-induced Oxidative Stress and Related Effects and Mechanisms in Liver, 1991-2017	9
A Comprehensive Review on Linum usitatissimum Medicinal Plant: Its Phytochemistry, Pharmacology, and Ethnomedicinal Uses	9
Nano-Strategies for Improving the Bioavailability of Inhaled Pharmaceutical Formulations	9

Ultrasmall Europium, Gadolinium, and Dysprosium Oxide Nanoparticles: Polyol Synthesis, Properties, and Biomedical Imaging Applications	9
Interactions of Dehydrogenase Enzymes with Nanoparticles Industrial and Medical Applications and Challenges: Mini-review	9
Recent Progress of Bioactivities, Mechanisms of Action, Total Synthesis, Structural Modifications and Structure-activity Relationships of Indole Derivatives: A Review	9
Medicinal and Biological Significance of Phenoxazine Derivatives	9
Recent Updates on Free Fatty Acid Receptor 1 (GPR-40) Agonists for the Treatment of Type 2 Diabetes Mellitus	9
PROTACs in Treatment of Cancer: A Review	9
Effectiveness of Azithromycin as Add-on Therapy in COVID-19 Management	9
The Role of the Cannabinoid System in Opioid Analgesia and Tolerance	9
Quinoxaline: A Chemical Moiety with Spectrum of Interesting Biological Activities	9
Synthesis of Azoloquinazolines and Substituted Benzothiazepine as Antimicrobial Agents	9
Natural Terpenoids as Neuroinflammatory Inhibitors in LPS-stimulated BV-2 Microglia	9
Appraisal of the Role of In silico Methods in Pyrazole Based Drug Design	9
Plant Polyphenols: Natural and Potent UV-Protective Agents for the Prevention and Treatment of Skin Disorders	9
Computational Studies on Acetylcholinesterase Inhibitors: From Biochemistry to Chemistry	8
Mediterranean Diet Polyphenols: Anthocyanins and Their Implications for Health	8
Effective Pharmacophore for CDC25 Phosphatases Enzyme Inhibitors: Newly Synthesized Bromothiazolopyrimidine Derivatives	8
Recent Update on the Anti-infective Potential of β-carboline Analogs	8
Applications of ROS-InducedZr-MOFs Platform in Multimodal Synergistic Therapy	8
A Review on a Medicinal and Edible Plant: Aralia elata (Miq.) Seem.	8
Anticancer Activity of Diosgenin and Its Semi-synthetic Derivatives: Role in Autophagy Mediated Cell Death and Induction of Apoptosis	8
A Comprehensive Review on Therapeutic Applications of Ferulic Acid and its Novel Analogues: A Brief Literature	8
Consensus Analyses in Molecular Docking Studies Applied to Medicinal Chemistry	8
Recent Advances in the Development of Macrolide Antibiotics as Antimicrobial Agents	8
G-Protein Coupled Receptors Involved in the Resolution of Inflammation: Ligands and Therapeutic Perspectives	8
Prognostic Implications of Immunohistochemical Biomarkers in Non-muscle-invasive Blad Cancer and Muscle-invasive Bladder Cancer	8
The Research Progress of DPP-4 Inhibitors	8
Therapeutic Potential of Resveratrol in the Treatment of Glioma: Insights into its Regulatory Mechanisms	8
Therapeutic Potential of Cinnoline Core: A Comprehensive Review	8
Medicinal Chemistry Meets Electrochemistry: Redox Potential in the Role of Endpoint or Molecular Descriptor in QSAR/QSPR	8
Recent Developments in Sodium-Glucose Co-Transporter 2 (SGLT2) Inhibitors as a Valuable Tool in the Treatment of Type 2 Diabetes Mellitus	8
Natural Bioactive New Withanolides	8
GSK-3β and its Inhibitors in Alzheimer's Disease: A Recent Update	8
Recent Updates on Antifungal Peptides	8
Human Galectin-1 in Multiple Cancers: A Privileged Molecular Target in Oncology	8
The Potential Application of Novel Drug Delivery Systems for Phytopharmaceuticals and Natural Extracts – Current Status and Future Perspectives	8
Biodegradable Polymers and their Applications: A Review	8
Triple Negative Breast Cancer: How Neurokinin-1 Receptor Antagonists Could Be Used as a New Therapeutic Approach	8
Brassica oleracea var. capitata f. alba: A Review on its Botany, Traditional uses, Phytochemistry and Pharmacological Activities	8
A Review: Discovering 1,3,4-oxadiazole and Chalcone Nucleus for Cytotoxicity / EGFR Inhibitory Anticancer Activity	8
Astaxanthin and Nrf2 Signaling Pathway: A Novel Target for New Therapeutic Approaches	8
An Overview of the Synthetic Route to the Marketed Formulations of Pyrimidine: A Review	8