Mini-Reviews in Medicinal Chemistry

Papers
(The median citation count of Mini-Reviews in Medicinal Chemistry is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)
ArticleCitations
Parkinson’s Disease: A Review from Pathophysiology to Treatment100
Biological Nanofactories: Using Living Forms for Metal Nanoparticle Synthesis86
The Roles of Flavonols/Flavonoids in Neurodegeneration and Neuroinflammation80
Potent Acetylcholinesterase Inhibitors: Potential Drugs for Alzheimer’s Disease67
Anticancer Potential of Coumarin and its Derivatives62
Thiosemicarbazones as Potent Anticancer Agents and their Modes of Action62
Synthesis and Biological Activity of Hydrazones and Derivatives: A Review61
Benzimidazole: A Milestone in the Field of Medicinal Chemistry60
Natural Polysaccharides with Immunomodulatory Activities54
From Antibacterial to Antitumour Agents: A Brief Review on The Chemical and Medicinal Aspects of Sulfonamides44
Monoterpenes: Essential Oil Components with Valuable Features39
Antiviral Activities of Pyridine Fused and Pyridine Containing Heterocycles, A Review (from 2000 to 2020)37
Novel Hybrid Molecules Based on triazole-β-lactam as Potential Biological Agents35
The Role of EGCG in Breast Cancer Prevention and Therapy.33
Ferulic Acid and Cardiovascular Health: Therapeutic and Preventive Potential32
Resistance to Intervention: Paclitaxel in Breast Cancer32
Herbal Drugs and Natural Products in the light of Nanotechnology and Nanomedicine for Developing Drug Formulations32
Recent Applications of Azo Dyes: A Paradigm Shift from Medicinal Chemistry to Biomedical Sciences32
Medicinal Thiols: Current Status and New Perspectives31
Fenugreek Cultivation with Emphasis on Historical Aspects and its uses in Traditional Medicine and Modern Pharmaceutical Science29
Osthole: A Multifunctional Natural Compound with Potential Anticancer, Antioxidant and Anti-inflammatory Activities29
Plumbagin: A Potential Anti-cancer Compound29
Recent Progress in Anticancer Agents Incorporating Pyrazole Scaffold28
Applications of Quantitative Structure-Activity Relationships (QSAR) based Virtual Screening in Drug Design: A Review28
Medicinal Plants in the Treatment of Peptic Ulcer Disease: A Review27
Current and Advanced Nanomaterials in Dentistry as Regeneration Agents: An Update27
An Appraisal of Current Pharmacological Perspectives of Sesamol: A Review27
An Insight into the Synthesis and SAR of 2,4-Thiazolidinediones (2,4-TZD) as Multifunctional Scaffold: A Review26
Recent Advancements on Benzimidazole: A Versatile Scaffold in Medicinal Chemistry25
Pharmacological Actions and Underlying Mechanisms of Catechin: A Review25
Paeonol Derivatives and Pharmacological Activities: A Review of Recent Progress25
Advancement in Pharmacological Activities of Benzothiazole and its Derivatives: An Up to Date Review24
Molecular Mechanisms of the Action of Myricetin in Cancer24
Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives24
Psoralen: A Biologically Important Coumarin with Emerging Applications24
Isatin: A Scaffold with Immense Biodiversity23
Quinoline: An Attractive Scaffold in Drug Design23
Recent Developments of Target Based Coumarin Derivatives as Potential Anticancer Agents23
A Review on Anticancer Activities of Thiophene and Its Analogs23
Lignans from Medicinal Plants and their Anticancer Effect23
A Recent Appraisal of Artificial Intelligence and In Silico ADMET Prediction in the Early Stages of Drug Discovery23
Traditional Uses, Therapeutic Effects and Recent Advances of Curcumin: A Mini-Review22
Imidazole Derivatives and their Antibacterial Activity – a Mini-Review22
Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity21
A Panoramic Review of Benzimidazole Derivatives and their Potential Biological Activity21
Advances in Anti-inflammatory Activity, Mechanism and Therapeutic Application of Ursolic Acid21
Influence of Plant Bioactive Compounds on Intestinal Epithelial Barrier in Poultry21
Thymoquinone: A Review on its Pharmacological Importance, and its Association with Oxidative Stress, COVID-19, and Radiotherapy20
Anticancer and Antimicrobial Activities of Naproxen and Naproxen Derivatives20
A Review on the Pharmacokinetic Properties of Naringin and Its Therapeutic Efficacies in Respiratory Diseases20
Antioxidant, Anti-inflammatory, Antibacterial, and Analgesic Activities and Mechanisms of Quinolines, Indoles and Related Derivatives19
New Development of Novel Berberine Derivatives against Bacteria19
Zinc Poisoning - Symptoms, Causes, Treatments19
Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi18
Structure-Activity Relationships of Natural and Synthetic Indole-Derived Scaffolds as α-Glucosidase Inhibitors: A Mini-Review18
An Updated Review of Various Medicinal Applications of p-Co umaric Acid: From Antioxidative and Anti-Inflammatory Properties to Effects on Cell Cycle and Proliferation18
First Synthesis for Bis-Spirothiazolidine Derivatives as a Novel Heterocyclic Framework and Their Biological Activity18
Medicinal Plant Centipeda Minima: A Resource of Bioactive Compounds18
Current Trends in Drug Delivery System of Curcumin and its Therapeutic Applications18
Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity18
Curcumin: An Insight into Molecular Pathways Involved in Anticancer Activity18
An Updated Review of Secondary Metabolites from Marine Fungi18
The Advances on the Protective Effects of Ginsenosides on Myocardial Ischemia and Ischemia-Reperfusion Injury17
Update on Acrylic Resins Used in Dentistry17
The Application of the Combination of Monte Carlo Optimization Method based QSAR Modeling and Molecular Docking in Drug Design and Development17
Thiosemicarbazides: Updates on Antivirals Strategy17
Diversified Synthetic Pathway of 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules17
Isatin Hybrids and Their Pharmacological Investigations16
Antimicrobial Properties of Mandelic Acid, Gallic Acid and their Derivatives16
Hypericin Ameliorates Maternal Separation-Induced Cognitive Deficits and Hippocampal Inflammation in Rats16
Inhibitors of Cholinesterases in Pharmacology: the Current Trends16
Structure and Activity of Pentacyclic Triterpenes Codrugs. A Review16
Synthesis and Biological Activity of Embelin and its Derivatives: An Overview16
Macrolactin Antibiotics: Amazing Natural Products15
Recent Progress of Oridonin and Its Derivatives for the Treatment of Acute Myelogenous Leukemia15
Current Insights into the Chemistry and Antitubercular Potential of Benzimidazole and Imidazole Derivatives15
Herbal Extracts with Antifungal Activity against Candida albicans: A Systematic Review15
Emerging Role of Terpenoids for the Treatment of Cancer: A Review15
Therapeutic Journey of Andrographis paniculata (Burm.f.) Nees from Natural to Synthetic and Nanoformulations15
1,3,4-Oxadiazole Containing Compounds As Therapeutic Targets For Cancer Therapy15
Will Arsenic Trioxide Benefit Treatment of Solid Tumor by Nano- Encapsulation?15
Association of Micro RNA and Postoperative Cognitive Dysfunction: A Review15
The Chemistry of Triazine Isomers: Structures, Reactions, Synthesis and Applications15
Antioxidant Activity of 1,2,4-Triazole and its Derivatives: A Mini-Review15
Marine Sponge-Associated Fungi as Potential Novel Bioactive Natural Product Sources for Drug Discovery: A Review14
Moringa Oleifera: A Review of Its Occurrence, Pharmacological Importance and Oxidative Stress14
Virtual Screening of Natural Products Database14
A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies14
Pyridine Moiety: An Insight into Recent Advances in the Treatment of Cancer14
Anti-aging Natural Compounds and their Role in the Regulation of Metabolic Pathways Leading to Longevity14
Advances in Ethnobotany, Synthetic Phytochemistry and Pharmacology of Endangered Herb Picrorhiza kurroa (Kutki): A Comprehensive Review (2010-2020)14
A Systematic Review of Current Progresses in the Nucleic Acid-Based Therapies for Neurodegeneration with Implications for Alzheimer’s Disease13
Cyclopropyl Scaffold: A Generalist for Marketed Drugs13
Multitarget Directed Ligand Approaches for Alzheimer’s Disease: A Comprehensive Review13
The Role of 3'UTR of RNA Viruses on mRNA Stability and Translation Enhancement13
Anticancer Agents Based on Vulnerable Components in a Signalling Pathway12
Pharmacokinetics-based Dose Management of 5-Fluorouracil Clinical Research in Advanced Colorectal Cancer Treatment12
Chromenes - A Novel Class of Heterocyclic Compounds: Recent Advancements and Future Directions12
1,8-Naphthyridine Derivatives: A Privileged Scaffold for Versatile Biological Activities12
Synthesis, Cytotoxicity and Molecular Docking Simulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages12
Pharmacological Efficacy and Safety of Glycyrrhiza glabra in the Treatment of Respiratory Tract Infections12
Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor- Kappa B (NF-kB) Inhibitors12
Carbazole Derivatives as Kinase-Targeting Inhibitors for Cancer Treatment12
Recent Advances in the Development of Fatty Acid Synthase Inhibitors as Anticancer Agents12
Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery12
Medicinally Privileged Sultams: Synthesis and Mechanism of Action12
Irreversible Kinase Inhibitors Targeting Cysteine Residues and their Applications in Cancer Therapy12
Advances on the Anti-Inflammatory Activity of Oleanolic Acid and Derivatives12
Medicinal Potential of Heterocyclic Compounds from Diverse Natural Sources for the Management of Cancer12
Adhatoda vasica (Nees.): A Review on its Botany, Traditional uses, Phytochemistry, Pharmacological Activities and Toxicity11
Glitazones, PPAR-γ and Neuroprotection11
Biological Role of AKT and Regulation of AKT Signaling Pathway by Thymoquinone: Perspectives in Cancer Therapeutics11
Novel Niacin Receptor Agonists: A Promising Strategy for the Treatment of Dyslipidemia11
Role of Cathepsin B in Cancer Progression: A Potential Target for Coordination Compounds11
A Review of the Effects of Gold, Silver, Selenium, and Zinc Nanoparticles on Diabetes Mellitus in Murine Models11
Diverse Thiophenes as Scaffolds in Anti-cancer Drug Development: A Concise Review11
Novel Mitochondria-targeted Drugs for Cancer Therapy11
Advances in Research on the Preparation and Biological Activity of Maslinic Acid11
Ferroptosis Inhibitors as Potential New Therapeutic Targets for Cardiovascular Disease11
Phytotherapy for Wound Healing: The Most Important Herbal Plants in Wound Healing Based on Iranian Ethnobotanical Documents11
A Review on Classification and Biological Activities of Alkaloids from the Genus Zanthoxylum Species11
The Importance of Rhodanine Scaffold in Medicinal Chemistry: A Comprehensive Overview11
Andrographolide: Synthetic Methods and Biological Activities11
Xanthone: Potential Acetylcholinesterase Inhibitor for Alzheimer's Disease Treatment11
Design, Synthesis, Molecular Docking Study and Anti-Hepatocellular Carcinoma Evaluation of New Bis-Triazolothiadiazines10
Research Progress in Alpha-fetoprotein-induced Immunosuppression of Liver Cancer10
The Zinc-dependent HDACs: Non-histone Substrates and Catalytic Deacylation Beyond Deacetylation10
An Insight in Pathophysiological Mechanism of Alzheimer’s Disease and its Management Using Plant Natural Products10
Design, Synthesis, SAR Study, Antimicrobial and Anticancer Evaluation of Novel 2-Mercaptobenzimidazole Azomethine Derivatives10
p-Benzoquinone as a Privileged Scaffold of Pharmacological Significance: A Review10
Regulation of Catechins in Uric Acid Metabolism Disorder Related Human Diseases10
Modulation of Calcium Signaling in Glioblastoma Multiforme: A Therapeutic Promise for Natural Products10
Association of Zinc and Copper Status with Cardiovascular Diseases and their Assessment Methods: A Review Study10
Inhibition of S-protein RBD and hACE2 Interaction for Control of SARSCoV- 2 Infection (COVID-19)10
Advances in Pyrazole Based Scaffold as Cyclin-dependent Kinase 2 Inhibitors for the Treatment of Cancer10
Development of Natural Bioactive Alkaloids: Anticancer Perspective10
Aquaporins and Roles in Brain Health and Brain Injury10
Therapeutic Journey and Recent Advances in the Synthesis of Coumarin Derivatives10
A Review on Vitamin E Natural Analogues and on the Design of Synthetic Vitamin E Derivatives as Cytoprotective Agents10
The Recent Development of Piperazine and Piperidine Derivatives as Antipsychotic Agents10
Advances on the Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships of Cytisine Derivatives10
Current Perspective of Synthesis of Medicinally Relevant Benzothiazole based Molecules: Potential for Antimicrobial and Anti-Inflammatory Activities10
Micro-RNA and the Features of Metabolic Syndrome: A Narrative Review10
Glycyrrhizin as a Potential Treatment for the Novel Coronavirus (COVID-19)10
The QSAR Paradigm in Fragment-Based Drug Discovery: From the Virtual Generation of Target Inhibitors to Multi-Scale Modeling10
The Quinazoline-Chalcone and Quinazolinone-Chalcone Hybrids: A Promising Combination for Biological Activity10
Medicinal and Biological Significance of Phenoxazine Derivatives9
Recent Updates on Free Fatty Acid Receptor 1 (GPR-40) Agonists for the Treatment of Type 2 Diabetes Mellitus9
PROTACs in Treatment of Cancer: A Review9
Effectiveness of Azithromycin as Add-on Therapy in COVID-19 Management9
The Role of the Cannabinoid System in Opioid Analgesia and Tolerance9
Quinoxaline: A Chemical Moiety with Spectrum of Interesting Biological Activities9
Synthesis of Azoloquinazolines and Substituted Benzothiazepine as Antimicrobial Agents9
Natural Terpenoids as Neuroinflammatory Inhibitors in LPS-stimulated BV-2 Microglia9
Appraisal of the Role of In silico Methods in Pyrazole Based Drug Design9
Plant Polyphenols: Natural and Potent UV-Protective Agents for the Prevention and Treatment of Skin Disorders9
Thiophene and Its Analogs as Prospective Antioxidant Agents: A Retrospective Study9
CRISPR-Cas9 Genome Engineering: Trends in Medicine and Health9
Assembly of Benzothiazine and Triazole in a Single Molecular Entity: Synthesis of -Oxicam Derived Novel Molecules as Potential Antibacterial/ Anti-cancer Agents9
Quercetin-Amino Acid Conjugates are Promising Anti-Cancer Agents in Drug Discovery Projects9
Multi-Target Drug Design of Anti-Alzheimer’s Disease based on Tacrine9
Coumarin-based Scaffold as α-glucosidase Inhibitory Activity: Implication for the Development of Potent Antidiabetic Agents9
Advances in BPA-induced Oxidative Stress and Related Effects and Mechanisms in Liver, 1991-20179
A Comprehensive Review on Linum usitatissimum Medicinal Plant: Its Phytochemistry, Pharmacology, and Ethnomedicinal Uses9
Nano-Strategies for Improving the Bioavailability of Inhaled Pharmaceutical Formulations9
Ultrasmall Europium, Gadolinium, and Dysprosium Oxide Nanoparticles: Polyol Synthesis, Properties, and Biomedical Imaging Applications9
Interactions of Dehydrogenase Enzymes with Nanoparticles Industrial and Medical Applications and Challenges: Mini-review9
Recent Progress of Bioactivities, Mechanisms of Action, Total Synthesis, Structural Modifications and Structure-activity Relationships of Indole Derivatives: A Review9
Brassica oleracea var. capitata f. alba: A Review on its Botany, Traditional uses, Phytochemistry and Pharmacological Activities8
Medicinal Chemistry Meets Electrochemistry: Redox Potential in the Role of Endpoint or Molecular Descriptor in QSAR/QSPR8
A Review: Discovering 1,3,4-oxadiazole and Chalcone Nucleus for Cytotoxicity / EGFR Inhibitory Anticancer Activity8
Astaxanthin and Nrf2 Signaling Pathway: A Novel Target for New Therapeutic Approaches8
An Overview of the Synthetic Route to the Marketed Formulations of Pyrimidine: A Review8
Computational Studies on Acetylcholinesterase Inhibitors: From Biochemistry to Chemistry8
Effective Pharmacophore for CDC25 Phosphatases Enzyme Inhibitors: Newly Synthesized Bromothiazolopyrimidine Derivatives8
The Potential Application of Novel Drug Delivery Systems for Phytopharmaceuticals and Natural Extracts – Current Status and Future Perspectives8
Applications of ROS-InducedZr-MOFs Platform in Multimodal Synergistic Therapy8
Triple Negative Breast Cancer: How Neurokinin-1 Receptor Antagonists Could Be Used as a New Therapeutic Approach8
Anticancer Activity of Diosgenin and Its Semi-synthetic Derivatives: Role in Autophagy Mediated Cell Death and Induction of Apoptosis8
A Comprehensive Review on Therapeutic Applications of Ferulic Acid and its Novel Analogues: A Brief Literature8
Consensus Analyses in Molecular Docking Studies Applied to Medicinal Chemistry8
Recent Advances in the Development of Macrolide Antibiotics as Antimicrobial Agents8
G-Protein Coupled Receptors Involved in the Resolution of Inflammation: Ligands and Therapeutic Perspectives8
Mediterranean Diet Polyphenols: Anthocyanins and Their Implications for Health8
The Research Progress of DPP-4 Inhibitors8
Recent Update on the Anti-infective Potential of β-carboline Analogs8
Therapeutic Potential of Cinnoline Core: A Comprehensive Review8
A Review on a Medicinal and Edible Plant: Aralia elata (Miq.) Seem.8
Recent Developments in Sodium-Glucose Co-Transporter 2 (SGLT2) Inhibitors as a Valuable Tool in the Treatment of Type 2 Diabetes Mellitus8
Natural Bioactive New Withanolides8
GSK-3β and its Inhibitors in Alzheimer's Disease: A Recent Update8
Recent Updates on Antifungal Peptides8
Human Galectin-1 in Multiple Cancers: A Privileged Molecular Target in Oncology8
Prognostic Implications of Immunohistochemical Biomarkers in Non-muscle-invasive Blad Cancer and Muscle-invasive Bladder Cancer8
Biodegradable Polymers and their Applications: A Review8
Therapeutic Potential of Resveratrol in the Treatment of Glioma: Insights into its Regulatory Mechanisms8
Imidazole: Multi-targeted Therapeutic Leads for the Management of Alzheimer’s Disease7
Curcumin as a Natural Modulator of B Lymphocytes: Evidence from In Vitro and In Vivo Studies7
Evodiamine: A Privileged Structure with Broad-ranging Biological Activities7
Hemoglobin F (HbF) Inducers; History, Structure and Efficacies7
A Short Review on Glucogallin and its Pharmacological Activities7
Current Biomedical and Diagnostic Applications of Gold Micro and Nanoparticles7
In Silico Modeling of the α7 Nicotinic Acetylcholine Receptor: New Pharmacological Challenges Associated with Multiple Modes of Signaling7
Phytochemical Profiles and their Anti-inflammatory Responses Against Influenza from Traditional Chinese Medicine or Herbs7
Antimicrobial Peptides: Vestiges of Past or Modern Therapeutics?7
Antiviral Drug Discovery and Development for Mayaro Fever – What do we have so far?7
Repurposed Antiviral Drugs for the Treatment of COVID-19: Syntheses, Mechanism of Infection and Clinical Trials7
Biomedical Implications of Plant-based Principles as Antidepressants: Prospects for Novel Drug Development7
A Review on Rotenoids: Purification, Characterization and its Biological Applications7
Osthole: Synthesis, Structural Modifications, and Biological Properties7
Genome-wide Core Proteome Analysis of Brucella melitensis Strains for Potential Drug Target Prediction7
Drug Re-purposing Approach and Potential Therapeutic Strategies to Treat COVID-197
The Research Progress of Direct Thrombin Inhibitors7
Tanshinones and their Derivatives: Heterocyclic Ring-Fused Diterpenes of Biological Interest7
Recent Developments in Nano-Drug Delivery Systems Loaded by Phytochemicals for Wound Healing7
Pharmacological and Therapeutic Aspects of Plants from the Genus Ferula: A Comprehensive Review7
A Comprehensive Review of Garcinia pedunculata Roxb. and its Therapeutic Potential6
DNA Interaction and Cytotoxic studies on Mono/Di-Oxo and Peroxo- Vanadium (V) complexes - A Review6
Novel Derivatives of Nicotinic Acid as Promising Anticancer Agents6
Current Progress in Biomedical Applications of Chitosan-Carbon Nanotube Nanocomposites: A Review6
Selection of Suitable Protein Structure from Protein Data Bank: An Important Step in Structure-based Drug Design Studies6
Progress and Development of C-3, C-6, and N-9 Positions Substituted Carbazole Integrated Molecular Hybrid Molecules as Potential Anticancer Agents6
A Review on Recent Developments in the Anticancer Potential of Oleanolic Acid and its Analogs (2017-2020)6
Anticancer Potential of Naringenin, Biosynthesis, Molecular Target, and Structural Perspectives6
Medicinal Chemistry of Multiple Sclerosis: Focus on Cladribine6
2-Substituted-mercapto-quinazolin-4(3H)-ones as DHFR Inhibitors6
Drug Discovery by Drug Repurposing: Combating COVID-19 in the 21st Century6
Discovery and Development of Antibacterial Agents: Fortuitous and Designed6
Overview of the Biological Activities of Pyrimido[4,5-d]pyrimidines6
Bioactivity of Natural Polyphenols as Antiparasitic Agents and their Biochemical Targets6
Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?6
Recent Progress in the Drug Development for the Treatment of Alzheimer’s Disease Especially on Inhibition of Amyloid-peptide Aggregation6
Advances in Biocatalytic Synthesis, Pharmacological Activities, Pharmaceutical Preparation and Metabolism of Ginsenoside Rh26
Single Heterocyclic Compounds as Monoamine Oxidase Inhibitors: From Past to Present6
Nanomaterials for Deep Tumor Treatment6
MicroRNA: A Potential Diagnosis for Male Infertility6
Discovering the Potentials of Medicinal Mushrooms in Combating Depression – A Review6
Effects of Green Tea (−)-Epigallocatechin-3-Gallate (EGCG) on Cardiac Function - A Review of the Therapeutic Mechanism and Potentials6
Phytochemicals and Potential Therapeutic Targets on Toxoplasma gondii Parasite6
A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review6
Cathepsin B-A Neuronal Death Mediator in Alzheimer’s Disease Leading to Neurodegeneration6
Strategies in Medicinal Chemistry to Discover New Hit Compounds against Ebola Virus: Challenges and Perspectives in Drug Discovery6
Research Progress of Essential Oil as a New Complementary Therapy in the Treatment of Depression5
Nuclear Medicine Application of Pentixafor/Pentixather Targeting CXCR4 for Imaging and Therapy in Related Disease5
The Role of LncRNA TUG1 in Obesity-related Diseases5
Small-Molecule Drugs in Immunotherapy5
Targeting Integrase Enzyme: A Therapeutic Approach to Combat HIV Resistance5
Chitosan: Applications in Drug Delivery System5
Natural Bridged Bicyclic Peptide Macrobiomolecules from Celosia argentea and Amanita phalloides5
Synthetic Approach to Potential Anticancer Benzimidazole Derivatives: A Review5
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