Mini-Reviews in Medicinal Chemistry

Article	Citations
A Review on Chemical Structures and Biological Activities of Dopamine Derivatives from Medicinal Insects	125
Targeting Lysosomes: A Strategy Against Chemoresistance in Cancer	84
Ferroptosis Inhibitors as Potential New Therapeutic Targets for Cardiovascular Disease	78
Comprehensive Update on Synthetic Aspects of Bosentan Derivatives	54
Current Insight on the Role of Glucokinase and Glucokinase Regulatory Protein in Diabetes	54
An Insight into the Combat Strategies for the Treatment of Type 2 Diabetes Mellitus	51
The Role of IL-6 Released During Exercise to Insulin Sensitivity and Muscle Hypertrophy	51
Synthesis of Phenothiazine Derivatives and their Diverse Biological Activities: A Review	49
Quinoxaline: A Chemical Moiety with Spectrum of Interesting Biological Activities	47
Current Perspective of Synthesis of Medicinally Relevant Benzothiazole based Molecules: Potential for Antimicrobial and Anti-Inflammatory Activities	47
Benefits of Manuka Honey in the Management of Infectious Diseases: Recent Advances and Prospects	45
Natural Products Databases for Drug Design	45
Recent Developments in Tacrine-based Hybrids as a Therapeutic Option for Alzheimer’s Disease	43
Aptamers Against COVID-19: An Untested Opportunity	41
Multitarget Directed Ligand Approaches for Alzheimer’s Disease: A Comprehensive Review	41
Synthetic Approach to Potential Anticancer Benzimidazole Derivatives: A Review	41
Meet the Editorial Board Member	40
Meet the Editorial Board Member	39
Advances in Exercise Therapy in Hemodialysis: A Systematic Review	38
Meet the Editorial Board Member	38
Chemotherapeutic Strategies for Combating Staphylococcus aureus Infections	38
Meet the Editorial Board Member	38
KRAS Pathway-based Therapeutic Approaches in Pancreatic Cancer	35
Revolutionizing Playing with Skeleton Atoms: Molecular Editing Surgery in Medicinal Chemistry	31
Irisin and Energy Metabolism and the Role of Irisin on Metabolic Syndrome	30

Bioactive Flavonoids: A Comparative Overview of the Biogenetic and Chemical Synthesis Approach	29
The Critical Function of microRNAs in Developing Resistance against 5- Fluorouracil in Cancer Cells	29
The most Recent Compilation of Reactions of Enaminone Derivatives with various Amine Derivatives to Generate Biologically Active Compounds	29
Bioactive Sulfonamides Derived from Amino Acids: Their Synthesis and Pharmacological Activities	28
Anticancer Potential of Coumarin and its Derivatives	28
Regulatory T Cells: Subtle and Promising Achilles' Heel of Psoriasis - Atherosclerosis Comorbidity	28
Meet the Editorial Board Member	27
Molecular Insights on the Therapeutic Effect of Selected Flavonoids on Diabetic Neuropathy	27
Associate Editorial Board Members	27
Pharmacological Efficacy and Safety of Glycyrrhiza glabra in the Treatment of Respiratory Tract Infections	27
Recent Advancements in Strategies for Abnormal Protein Clearance in Alzheimer's Disease	27
Inhibitory Activities of Pyrazolo-Oxazine Heterocyclic Derivatives	26
Recent Advances in Nanobiotechnology for the Treatment of Non-Hodgkin’s Lymphoma	26
Natural Products with BACE1 and GSK3β Inhibitory Activity	26
A Review on Acridines as Antiproliferative Agents	24
The Pivotal Function of SLC16A1 and SLC16A1-AS1 in Cancer Progress: Molecular Pathogenesis and Prognosis	24
Cinnamic Acid Derivatives: Recent Discoveries and Development Strategies for Alzheimer’s Disease	23
Meet the Section Editor	23
Research Progress in Alpha-fetoprotein-induced Immunosuppression of Liver Cancer	22
Inhibitors of Epigenetic Modulators as Therapeutic Alternatives for Cardiovascular Diseases	21
Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships	21
Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor- Kappa B (NF-kB) Inhibitors	21
Antioxidant, Anti-inflammatory, Antibacterial, and Analgesic Activities and Mechanisms of Quinolines, Indoles and Related Derivatives	21
Meet the Editorial Board Member	20
The Role of MiR-29 in the Mechanism of Fibrosis	20
Meet the Editorial Board Member	20
Role of TBK1 Inhibition in Targeted Therapy of Cancer	20
Meet the Frontiers Section Editor	20
AGAP2-AS1: An Indispensable lncRNA in Tumors	19
Drug Solubilization by Surfactants: Experimental Methods and Theoretical Perspectives	19
Roles of Accelerated Molecular Dynamics Simulations in Predictions of Binding Kinetic Parameters	19
Carbohydrazide Analogues: A Review of Synthesis and Biological Activities	19
Recent Literature on the Synthesis of Thiazole Derivatives and their Biological Activities	19
Quinoline Derivatives as Promising Scaffolds for Antitubercular Activity: A Comprehensive Review	19
Meet the Editorial Board Member	18
Recent Advances in the Development of Type 2 Sodium-Glucose Cotransporter Inhibitors for the Treatment of Type 2 Diabetes Mellitus	18
Breaking Barriers in Breast Cancer: Multi-Targeted Therapeutic Insights	18
Nimbolide: A Potential Phytochemical Agent in Multimodal Pancreatic Cancer Therapies	18
Exploring the Therapeutic Potential of Green Tea (Camellia sinensis L.) in Anti-Aging: A Comprehensive Review of Mechanisms and Findings	18
Curcumin: An Insight into Molecular Pathways Involved in Anticancer Activity	17
Flavonoid-metal ion Complexes as Potent Anticancer Metallodrugs: A Comprehensive Review	17
Current Status of and Perspectives on Radiolabelled Ubiquicidin 29-41 Derivatives for Bacterial Infection Imaging	17
SET Protein in Cancer: A Potential Therapeutic Target	17
Development of Mycobacterium tuberculosis Enoyl Acyl Reductase (InhA) Inhibitors: A Mini-Review	17
The Art and Science of Antidiabetic Medications and Obesity Management	17
Natural Products, Synthesis, and Biological Activities of Quinolines (2020-2024)	16
Drug Repurposing: A Conduit to Unravelling Metabolic Reprogramming for Cancer Treatment	16
The Utilization and Development of Viral Vectors in Vaccines as a Prophylactic Treatment Against Ebola Virus as an Emerging and Zoonotic Infectious Disease	16
Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?	16
MicroRNAs and Efferocytosis: Implications for Diagnosis and Therapy	16

Homometallic Polynuclear Rhodium Complexes in Anticancer Drug Development	16
Meet the Editorial Board Member	16
N-Methyl-D-Aspartate (NMDA)-Type Glutamate Receptors and Demyelinating Disorders: A Neuroimmune Perspective	16
The Effects of Increased Glucose Level and Glycolysis on SARS CoV-2 Infection	16
Meet the Editorial Board Member	15
Meet the Editor-in-Chief	15
Meet the Editorial Board Member	15
Meet the Editorial Board Member	15
Therapeutic Potentials of Aconite-like Alkaloids: Bioinformatics and Experimental Approaches	14
Chemical Strategies Toward Prodrugs and Fluorescent Probes for Gasotransmitters	14
Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi	14
A Comprehensive Review on Chemistry and Biology of Tafamidis in Transthyretin Amyloidosis	14
Strategies in Taxol Development: A Review	14
Comprehensive Insight into Green Synthesis Approaches, Structural Activity Relationship, and Therapeutic Potential of Pyrazolic Chalcone Derivative	14
Recent Updates on Sinularia Soft Coral	14
Glycyrrhizin as a Potential Treatment for the Novel Coronavirus (COVID-19)	14
An Overview of Pyridazinone Analogs: Chemical and Pharmacological Potential	14
Inhibitors Targeting Hepatitis C Virus (HCV) Entry	14
Effects of Urtica dioica on Metabolic Profiles in Type 2 Diabetes: A Systematic Review and Meta-analysis of Clinical Trials	14
The Complex Roles of DNA Repair Pathways, Inhibitors, Hyperthermia, and Contact Inhibition in Cell Cycle Halts	14
Chemistry, Analysis, and Biological Aspects of Daprodustat, A New Hypoxia Inducible Factor Prolyl Hydroxylase Inhibitor: A Comprehensive Review	13
A Critical Observation on the Design and Development of Reported Peptide Inhibitors of DENV NS2B-NS3 Protease in the Last Two Decades	13
Meet the Editorial Board Member	13
Second-line Therapy for Helicobacter Pylori Eradication: State of the Art	13
Meet the Editorial Board Member	13
Meet the Editorial Board Member	13
Indole-3-carbinol (I3C) as Leukemia Therapeutic Agents: Review	13
The Search for Antidotes Against Ricin	13
Uncovering the Potential of Lipid Drugs: A Focus on Transient Membrane Microdomain-targeted Lipid Therapeutics	13
Meet the Editorial Board Member	13
A Review on a Medicinal and Edible Plant: Aralia elata (Miq.) Seem.	12
Use of Chitosan as a Precursor for Multiple Applications in Medicinal Chemistry: Recent Significant Contributions	12
Energy Metabolism Behavior and Response to Microenvironmental Factors of the Experimental Cancer Cell Models Differ from that of Actual Human Tumors	12
Therapeutic Approaches for the Treatment of Interstitial Lung Disease: An Exploratory Review on Molecular Mechanisms	12
Melatonin and Related Compounds as Antioxidants	12
Chlorogenic Acid Derivatives: Structural Modifications, Drug Design, and Biological Activities: A Review	12
The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex® - A Cannabis-derived Spray	12
Radical Releasing Anti-tuberculosis Agents and the Treatment of Mycobacterial Tuberculosis Infections - An Overview	12
In vivo Pharmacokinetic and ADMET Profiles of Synthetic Antimicrobial Peptides (AMPs)	12
The Application of the Pyrazole Structure in the Structural Modification of Natural Products	12
The Situation of Small Molecules Targeting Key Proteins in combatting SARS-CoV-2: Synthesis, Metabolic Pathway, Mechanism of Action, and Potential Therapeutic Applications	12
Nuclei-targeted Therapeutic Delivery: A Novel Concept for the Treatment of Cancer	12
A Therapeutic Journey of Potential Drugs Against COVID-19	12
Nutraceuticals, a Bridge Between Past and Future: Focus on Mushrooms Biological Activities and Myco-Chemistry	11
Anthriscus sylvestris: An overview on Bioactive Compounds and Anticancer Mechanisms from a Traditional Medicinal Plant to Modern Investigation	11
Narrative Review of the Pharmacodynamics, Pharmacokinetics, and Toxicities of Illicit Synthetic Cannabinoid Receptor Agonists	11
Novel Niacin Receptor Agonists: A Promising Strategy for the Treatment of Dyslipidemia	11
Recent Insights of Metformin on Hepatocellular Carcinoma (HCC)	11
Protective Effect of Plumeria Pudica Latex Proteins on Intestinal Mucositis Induced by 5-Fluorouracil	11
Targeting Bcl-2 with Indole Scaffolds: Emerging Drug Design Strategies for Cancer Treatment	11
Aloe-emodin: Progress in Pharmacological Activity, Safety, and Pharmaceutical Formulation Applications	11
Recent Advancements and SAR Studies of Synthetic Coumarins as MAO-B Inhibitors: An Updated Review	11
The Role of Genetics and Synergistic Effect of Targeting Common Genetic Mutations in Acute Lymphoblastic Leukemia (ALL)	11
Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing	11
Meet the Editorial Board Member	11
Nicotinamide Adenine Dinucleotide in the Development and Treatment of Cardiac Remodeling and Aging	11
Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity	11
Antioxidant Activity of 1,2,4-Triazole and its Derivatives: A Mini-Review	11
Xanthone: Potential Acetylcholinesterase Inhibitor for Alzheimer's Disease Treatment	11
Exploring the Versatility of Azine Derivatives: A Comprehensive Review on Synthesis and Biological Applications	11
New Insights into the Modifications and Bioactivities of Indole-3- Carboxaldehyde and its Derivatives as a Potential Scaffold for Drug Design: A Mini-Review	11
Acknowledgements to Reviewers	11
Agent in Urgent Need of Clinical Practice: Corilagin	11
The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases	11
Modulation of Long Non-coding RNAs by Different Classes of Secondary Metabolites from Plants: A Mini-review on Antitumor Effects	10
Anticancer Potential of Naringenin, Biosynthesis, Molecular Target, and Structural Perspectives	10
Advances in Biocatalytic Synthesis, Pharmacological Activities, Pharmaceutical Preparation and Metabolism of Ginsenoside Rh2	10
Meet the Co-Editor	10
Recent Progress Towards Vaccines and Antibody-based Therapies Against Alzheimer's Disease	10
Recent Studies on the Pharmacological Activities and Structural Modifications of Compound-K	10
Synthesis and Biological Properties of Isatin-indole Hybrids: A Review	10
Peroxisome Proliferator-activated Receptor-γ As A Novel and Promising Target For Treating Cancer Via Regulation of Inflammation: A Brief Review	10
Research Progress in Mutagenesis Techniques for Aspergillus fumigatus and the Biological Activities of Fumagillin	10
Some Scaffolds as Anti-leishmanial Agents: A Review	10
Meet the Editor in Chief	10
The Indispensable Roles of GMDS and GMDS-AS1 in the Advancement of Cancer: Fucosylation, Signal Pathway and Molecular Pathogenesis	10
Meet the Executive Guest Editor	10
Cardiovascular Effects of Ruthenium Complexes: A Potential Therapeutic Tool in Hypertension and Myocardial Injury	10
A Short Review on Glucogallin and its Pharmacological Activities	10
Recent Development of CXCR4-Targeted Nuclear Medicine Research in Adrenocortical Tumors	10

Meet the Editorial Board Member	10
Meet the Editorial Board Member	10
Natural and Synthetic Phosphodiesterase Inhibitors in 2023: an Update on the Impact on Neurological and Psychiatric Conditions	10
Elucidating the Drug Repurposing Spectra of COVID-19 with its Analogues SARS and MERS	9
Dendrobine: A neuroprotective Sesquiterpenic Alkaloid for the Prevention and Treatment of Diseases: A Review	9
Levothyroxine and Non-alcoholic Fatty Liver Disease: A Mini Review	9
An Updated Review of Various Medicinal Applications of p-Co umaric Acid: From Antioxidative and Anti-Inflammatory Properties to Effects on Cell Cycle and Proliferation	9
LncRNA DSCAM-AS1: A Pivotal Therapeutic Target in Cancer	9
Bioactivities of Dietary Polyphenols and Their Effects on Intestinal Microbiota	9
The Use of Nanocarriers to Enhance the Anti-neuroinflammatory Potential of Dietary Flavonoids in Animal Models of Neurodegenerative Diseases: A Systematic Review	9
MCM3AP-AS1: A LncRNA Participating in the Tumorigenesis of Cancer Through Multiple Pathways	9
Natural Product-based Therapies for Inflammatory Bowel Disease: Targeting Key Signaling Pathways	9
Lyophilization of Molecular Biology Reactions: A Review	9
Meet the Editorial Board Member	9
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment	9
Recent Advances in Small Molecular PET Tracers for Pancreatic Cancer Diagnosis: Preclinical Stage	9
Systematic Review of the Serotonergic System in the Pathophysiology of Severe Dengue: The Theory of Thrombocytopenia and Vascular Extravasation	9
Cathepsin B-A Neuronal Death Mediator in Alzheimer’s Disease Leading to Neurodegeneration	9
Biological Activities of Morita-Baylis-Hillman Adducts (MBHA)	9
Acknowledgements to Reviewers	9
Fungal Endophytes: A Storehouse of Bioactive Compounds	9
Alzheimer's Disease and Cancer: Common Targets	8
Role of Caffeine in the Age-related Neurodegenerative Diseases: A Review	8
Meet the Associate Editorial Board Member	8
Acknowledgement to Reviewers	8
The Role of 3'UTR of RNA Viruses on mRNA Stability and Translation Enhancement	8
The Role of Renin-Angiotensin System in Diabetic Nephropathy: An Update	8
Exploring Tetrahydroisoquinoline (THIQ) Scaffold as Therapeutic Modulators of Sigma Receptors	8
Meet the Associate Editorial Board Member	8
The Emergence of N. sativa L. as a Green Antifungal Agent	8
Research Progress of Tamarixetin and its Glycosides	8
Therapeutic Potential of Thiophene Compounds: A Mini-Review	8
Recent Advances in Fluorescent Probes for G-quadruplex DNAs / RNAs	8
Mitochondria as a Therapeutic Target in Metabolic Disorders	8
An Updated and Focused Review on Heterocyclic Inhibitors for SARSCoV and SARS-CoV-2 3CLpro	8
Comparative Review of Effects of Pien Tze Huang and AnGong NiuHuang Pill and their Potential on Treatment of Central Nervous System Diseases	8
Brassica oleracea var. capitata f. alba: A Review on its Botany, Traditional uses, Phytochemistry and Pharmacological Activities	8
Pyridine Moiety: An Insight into Recent Advances in the Treatment of Cancer	8
Dietary Intake of Hydrolyzable Tannins and Condensed Tannins to Regulate Lipid Metabolism	8
Developments in the Antitumor Activity, Mechanisms of Action, Structural Modifications, and Structure-Activity Relationships of Steroidal Saponins	7
A Concise and Useful Guide to Understand How Alpha1 Adrenoceptor Antagonists Work	7
Acknowledgements to Reviewers	7
Cyclin-Dependent Kinase 4/6 Inhibitors Against Breast Cancer	7
Osthole: Synthesis, Structural Modifications, and Biological Properties	7
Biodegradable Polymers and their Applications: A Review	7
Phage-choline Kinase Inhibitor Combination to Control Pseudomonas aeruginosa: A Promising Combo	7
Promising Enzymes for Inhibitors Development Against COVID-19	7
ZFPM2-AS1: An Oncogenic Long Non-coding RNA in Multiple Cancer Types	7
Meet the Section Editor	7
2-Substituted-mercapto-quinazolin-4(3H)-ones as DHFR Inhibitors	7
Meet the Editorial Board Member	7
Exploration of Potent Multi-target-directed-ligands as Anti-alzheimer’s Disease Agents: A Moiety Based Review	7
Emerging Role of Terpenoids for the Treatment of Cancer: A Review	7
The Roles, Mechanisms, and Clinical Significance of Long Non-coding RNA MSC-AS1 in Cancer	7
Effects of Green Tea (−)-Epigallocatechin-3-Gallate (EGCG) on Cardiac Function - A Review of the Therapeutic Mechanism and Potentials	7
Meet the Editorial Board Member	7
Mitochondrial Proteins as Metabolic Biomarkers and Sites for Therapeutic Intervention in Primary and Metastatic Cancers	7
Meet the Section Editor	7
The Role of Epigenetic Mechanisms in Autoimmune, Neurodegenerative, Cardiovascular, and Imprinting Disorders	7
MiRNAs: Emerging Agents for Therapeutic Effects of Polyphenols on Ovarian Cancer	7
In silico Approaches for Exploring the Pharmacological Activities of Benzimidazole Derivatives: A Comprehensive Review	7
1,3,5-Triazine: Recent Development in Synthesis of its Analogs and Biological Profile	7
Withdrawal: Advances in Development of Drugs for Chronic Myelogenous Leukemia	7
A New Mode of Thinfilm and Nanofiber for Burst Release of the Drug for Alzheimer Disease; A Complete Scenario from Dispersible Polymer to Formulation Methodology	7
Gastrointestinal, Liver, Pancreas, Oral and Psychological Long-term Symptoms of COVID-19 After Recovery: A Review	7
Mini-Review on Vitamin D in Pediatric Population and its Role in Respiratory and Atopic Disorders	7
Exploring Genetic Silencing: RNAi and CRISPR-Cas Potential against Drug Resistance in Malaria	7
Cytotoxic Activity of Tropane Alkaloides of Species of Erythroxylum	6
The Progress of Small Molecule Targeting BCR-ABL in the Treatment of Chronic Myeloid Leukemia	6
Recent Development of DNA Gyrase Inhibitors: An Update	6
Potential of MAO-B Inhibitors with Multi-Target Inhibition and Antioxidant Properties for the Treatment of Neurodegenerative Disorders	6
Tanshinone IIA Against Cerebral Ischemic Stroke and Ischemia- Reperfusion Injury: A Review of the Current Documents	6
Research Progress of Diterpenoids with Potential Antidiabetic Activity	6
Research Progress on the Natural Product Aloperine and Its Derivatives	6
Tuberculosis, BCG Vaccination, and COVID-19: Are They Connected?	6
Recent Progress of Bioactivities, Mechanisms of Action, Total Synthesis, Structural Modifications and Structure-activity Relationships of Indole Derivatives: A Review	6
Antidiabetic Properties of Dietary Chrysin: A Cellular Mechanism Review	6
Preface	6
A Review and Meta-analysis on Trastuzumab Resistance in Patients with HER2+ Breast Cancer	6
The Recent Developments of ADCs with the Tubulysins as the Payloads	6
Effectiveness of Azithromycin as Add-on Therapy in COVID-19 Management	6
Insight in Quinazoline-based HDAC Inhibitors as Anti-cancer Agents	6
Nano-biotechnology and its Innovative Perspective in Diabetes Management	6
Chitosan: Applications in Drug Delivery System	6
Anti-aging Natural Compounds and their Role in the Regulation of Metabolic Pathways Leading to Longevity	6
Emerging Role of Dendrobium Orchid Plants in Diabetes: Phytochemistry Aspects, SAR, and Therapeutic Potential	6
Molecular Targets for Chalcones in Antileishmanial Drug Discovery	6
Methyl-linked Pyrazoles: Synthetic and Medicinal Perspective	6
Innovative Theranostics Strategies in the Fight Against Lung Cancer	6
Anti-Tubercular Activity of Pyrazinamide Conjugates: Synthesis and Structure-Activity Relationship Studies	6
Nuclear Medicine Application of Pentixafor/Pentixather Targeting CXCR4 for Imaging and Therapy in Related Disease	6
Research Progress of α-Synuclein Aggregation Inhibitors for Potential Parkinson’s Disease Treatment	5
Advances in the Development of Non-Structural Protein 1 (NsP1) Inhibitors for the Treatment of Chikungunya Virus Infection	5
Research and Progress of Probucol in Nonalcoholic Fatty Liver Disease	5
Pharmaceutical Studies on Piperazine-based Compounds Targeting Serotonin Receptors and Serotonin Reuptake Transporters	5