Mini-Reviews in Medicinal Chemistry

Article	Citations
Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems	101
Targeting Lysosomes: A Strategy Against Chemoresistance in Cancer	69
The Role of IL-6 Released During Exercise to Insulin Sensitivity and Muscle Hypertrophy	62
A Review on Chemical Structures and Biological Activities of Dopamine Derivatives from Medicinal Insects	57
Protein and Small-Molecule Leucopoiesis and Thrombopoiesis Stimulators	53
Natural Products Databases for Drug Design	53
Comprehensive Update on Synthetic Aspects of Bosentan Derivatives	48
Recent Developments in Tacrine-based Hybrids as a Therapeutic Option for Alzheimer’s Disease	47
Hypericin Ameliorates Maternal Separation-Induced Cognitive Deficits and Hippocampal Inflammation in Rats	43
Multi-Target Drug Design of Anti-Alzheimer’s Disease based on Tacrine	40
Current Insight on the Role of Glucokinase and Glucokinase Regulatory Protein in Diabetes	40
Aptamers Against COVID-19: An Untested Opportunity	39
Multitarget Directed Ligand Approaches for Alzheimer’s Disease: A Comprehensive Review	38
Ferroptosis Inhibitors as Potential New Therapeutic Targets for Cardiovascular Disease	38
A Review on Rotenoids: Purification, Characterization and its Biological Applications	38
Synthetic Approach to Potential Anticancer Benzimidazole Derivatives: A Review	38
Quinoxaline: A Chemical Moiety with Spectrum of Interesting Biological Activities	36
An Insight into the Combat Strategies for the Treatment of Type 2 Diabetes Mellitus	35
Benefits of Manuka Honey in the Management of Infectious Diseases: Recent Advances and Prospects	34
Current Perspective of Synthesis of Medicinally Relevant Benzothiazole based Molecules: Potential for Antimicrobial and Anti-Inflammatory Activities	33
Meet the Editorial Board Member	33
Meet the Editorial Board Member	32
Meet the Editorial Board Member	30
Revolutionizing Playing with Skeleton Atoms: Molecular Editing Surgery in Medicinal Chemistry	29
The Critical Function of microRNAs in Developing Resistance against 5- Fluorouracil in Cancer Cells	28

Recent Advances in Natural Products with Antiviral Activities	28
KRAS Pathway-based Therapeutic Approaches in Pancreatic Cancer	27
The most Recent Compilation of Reactions of Enaminone Derivatives with various Amine Derivatives to Generate Biologically Active Compounds	27
Chemotherapeutic Strategies for Combating Staphylococcus aureus Infections	27
Meet the Editorial Board Member	26
Advances in Exercise Therapy in Hemodialysis: A Systematic Review	25
Irisin and Energy Metabolism and the Role of Irisin on Metabolic Syndrome	25
Bioactive Flavonoids: A Comparative Overview of the Biogenetic and Chemical Synthesis Approach	25
Bioactive Sulfonamides Derived from Amino Acids: Their Synthesis and Pharmacological Activities	24
Anticancer Potential of Coumarin and its Derivatives	24
A Mini Review on Emerging Targets and Approaches for the Synthesis of Anti-viral Compounds: In Perspective to COVID-19	24
Associate Editorial Board Members	23
Meet the Editorial Board Member	22
Role of TBK1 Inhibition in Targeted Therapy of Cancer	22
Research Progress in Alpha-fetoprotein-induced Immunosuppression of Liver Cancer	22
Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor- Kappa B (NF-kB) Inhibitors	21
Antioxidant, Anti-inflammatory, Antibacterial, and Analgesic Activities and Mechanisms of Quinolines, Indoles and Related Derivatives	21
Cinnamic Acid Derivatives: Recent Discoveries and Development Strategies for Alzheimer’s Disease	20
Recent Advances in Nanobiotechnology for the Treatment of Non-Hodgkin’s Lymphoma	20
Molecular Insights on the Therapeutic Effect of Selected Flavonoids on Diabetic Neuropathy	19
A Review on Acridines as Antiproliferative Agents	19
Natural Products with BACE1 and GSK3β Inhibitory Activity	19
Recent Advancements in Strategies for Abnormal Protein Clearance in Alzheimer's Disease	19
The Role of MiR-29 in the Mechanism of Fibrosis	18
Inhibitory Activities of Pyrazolo-Oxazine Heterocyclic Derivatives	18
Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships	18
The Pivotal Function of SLC16A1 and SLC16A1-AS1 in Cancer Progress: Molecular Pathogenesis and Prognosis	18
Meet the Section Editor	18
Pharmacological Efficacy and Safety of Glycyrrhiza glabra in the Treatment of Respiratory Tract Infections	17
Reviewing Propolis with Multi-components in the Treatment of Oral Diseases through Multi-pathways and Multi-targets	17
Meet Our Editorial Board Member	17
Ferulic Acid and Cardiovascular Health: Therapeutic and Preventive Potential	17
AGAP2-AS1: An Indispensable lncRNA in Tumors	17
Roles of Accelerated Molecular Dynamics Simulations in Predictions of Binding Kinetic Parameters	16
Meet the Editorial Board Member	16
Carbohydrazide Analogues: A Review of Synthesis and Biological Activities	16
Meet the Frontiers Section Editor	16
Exploring the Therapeutic Potential of Green Tea (Camellia sinensis L.) in Anti-Aging: A Comprehensive Review of Mechanisms and Findings	16
Meet the Editorial Board Member	16
Recent Literature on the Synthesis of Thiazole Derivatives and their Biological Activities	15
Glitazones, PPAR-γ and Neuroprotection	15
Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?	15
A Critical Review on Recent Development of Techniques and Drug Targets in the Management of Breast Cancer	15
Nimbolide: A Potential Phytochemical Agent in Multimodal Pancreatic Cancer Therapies	15
Meet the Editorial Board Member	15
Quinoline Derivatives as Promising Scaffolds for Antitubercular Activity: A Comprehensive Review	15
Drug Solubilization by Surfactants: Experimental Methods and Theoretical Perspectives	15
Current Status of and Perspectives on Radiolabelled Ubiquicidin 29-41 Derivatives for Bacterial Infection Imaging	15
Recent Advances in the Development of Type 2 Sodium-Glucose Cotransporter Inhibitors for the Treatment of Type 2 Diabetes Mellitus	14
MicroRNAs and Efferocytosis: Implications for Diagnosis and Therapy	14

SET Protein in Cancer: A Potential Therapeutic Target	14
Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships	13
Flavonoid-metal ion Complexes as Potent Anticancer Metallodrugs: A Comprehensive Review	13
The Effects of Increased Glucose Level and Glycolysis on SARS CoV-2 Infection	13
The Utilization and Development of Viral Vectors in Vaccines as a Prophylactic Treatment Against Ebola Virus as an Emerging and Zoonotic Infectious Disease	13
N-Methyl-D-Aspartate (NMDA)-Type Glutamate Receptors and Demyelinating Disorders: A Neuroimmune Perspective	13
Development of Mycobacterium tuberculosis Enoyl Acyl Reductase (InhA) Inhibitors: A Mini-Review	13
Drug Repurposing: A Conduit to Unravelling Metabolic Reprogramming for Cancer Treatment	12
Strategies in Taxol Development: A Review	12
Meet the Editor-in-Chief	12
Adhatoda vasica (Nees.): A Review on its Botany, Traditional uses, Phytochemistry, Pharmacological Activities and Toxicity	12
Inhibitors Targeting Hepatitis C Virus (HCV) Entry	12
Meet the Editorial Board Member	12
Curcumin: An Insight into Molecular Pathways Involved in Anticancer Activity	12
Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi	11
Recent Updates on Sinularia Soft Coral	11
The Complex Roles of DNA Repair Pathways, Inhibitors, Hyperthermia, and Contact Inhibition in Cell Cycle Halts	11
Overview of the Biological Activities of Pyrimido[4,5-d]pyrimidines	11
Human Galectin-1 in Multiple Cancers: A Privileged Molecular Target in Oncology	11
Glycyrrhizin as a Potential Treatment for the Novel Coronavirus (COVID-19)	11
Effects of Urtica dioica on Metabolic Profiles in Type 2 Diabetes: A Systematic Review and Meta-analysis of Clinical Trials	11
Chemical Strategies Toward Prodrugs and Fluorescent Probes for Gasotransmitters	11
Comprehensive Insight into Green Synthesis Approaches, Structural Activity Relationship, and Therapeutic Potential of Pyrazolic Chalcone Derivative	11
An Overview of Pyridazinone Analogs: Chemical and Pharmacological Potential	11
Therapeutic Potentials of Aconite-like Alkaloids: Bioinformatics and Experimental Approaches	11
Meet the Editorial Board Member	11
A Comprehensive Review on Chemistry and Biology of Tafamidis in Transthyretin Amyloidosis	11
Meet the Editorial Board Member	11
Meet the Editorial Board Member	11
Meet the Editorial Board Member	11
Indole-3-carbinol (I3C) as Leukemia Therapeutic Agents: Review	10
The Search for Antidotes Against Ricin	10
A Therapeutic Journey of Potential Drugs Against COVID-19	10
Use of Chitosan as a Precursor for Multiple Applications in Medicinal Chemistry: Recent Significant Contributions	10
Therapeutic Approaches for the Treatment of Interstitial Lung Disease: An Exploratory Review on Molecular Mechanisms	10
Second-line Therapy for Helicobacter Pylori Eradication: State of the Art	10
Melatonin and Related Compounds as Antioxidants	10
Energy Metabolism Behavior and Response to Microenvironmental Factors of the Experimental Cancer Cell Models Differ from that of Actual Human Tumors	10
Uncovering the Potential of Lipid Drugs: A Focus on Transient Membrane Microdomain-targeted Lipid Therapeutics	10
Meet the Editorial Board Member	10
The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex® - A Cannabis-derived Spray	10
Chemistry, Analysis, and Biological Aspects of Daprodustat, A New Hypoxia Inducible Factor Prolyl Hydroxylase Inhibitor: A Comprehensive Review	10
A Critical Observation on the Design and Development of Reported Peptide Inhibitors of DENV NS2B-NS3 Protease in the Last Two Decades	10
The Situation of Small Molecules Targeting Key Proteins in combatting SARS-CoV-2: Synthesis, Metabolic Pathway, Mechanism of Action, and Potential Therapeutic Applications	10
Chlorogenic Acid Derivatives: Structural Modifications, Drug Design, and Biological Activities: A Review	10
Meet the Editorial Board Member	10
Meet the Editorial Board Member	10
Radical Releasing Anti-tuberculosis Agents and the Treatment of Mycobacterial Tuberculosis Infections - An Overview	10
A Review on a Medicinal and Edible Plant: Aralia elata (Miq.) Seem.	10
Role of Cathepsin B in Cancer Progression: A Potential Target for Coordination Compounds	9
The Role of Genetics and Synergistic Effect of Targeting Common Genetic Mutations in Acute Lymphoblastic Leukemia (ALL)	9
Current Biomedical and Diagnostic Applications of Gold Micro and Nanoparticles	9
Exploring the Versatility of Azine Derivatives: A Comprehensive Review on Synthesis and Biological Applications	9
Anthriscus sylvestris: An overview on Bioactive Compounds and Anticancer Mechanisms from a Traditional Medicinal Plant to Modern Investigation	9
In vivo Pharmacokinetic and ADMET Profiles of Synthetic Antimicrobial Peptides (AMPs)	9
Nutraceuticals, a Bridge Between Past and Future: Focus on Mushrooms Biological Activities and Myco-Chemistry	9
Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing	9
Recent Advancements and SAR Studies of Synthetic Coumarins as MAO-B Inhibitors: An Updated Review	9
The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases	9
Xanthone: Potential Acetylcholinesterase Inhibitor for Alzheimer's Disease Treatment	9
The Application of the Pyrazole Structure in the Structural Modification of Natural Products	9
Recent Insights of Metformin on Hepatocellular Carcinoma (HCC)	9
New Insights into the Modifications and Bioactivities of Indole-3- Carboxaldehyde and its Derivatives as a Potential Scaffold for Drug Design: A Mini-Review	9
Narrative Review of the Pharmacodynamics, Pharmacokinetics, and Toxicities of Illicit Synthetic Cannabinoid Receptor Agonists	9
A Short Review on Glucogallin and its Pharmacological Activities	8
Antioxidant Activity of 1,2,4-Triazole and its Derivatives: A Mini-Review	8
Meet the Editorial Board Member	8
Aloe-emodin: Progress in Pharmacological Activity, Safety, and Pharmaceutical Formulation Applications	8
Nicotinamide Adenine Dinucleotide in the Development and Treatment of Cardiac Remodeling and Aging	8
Peroxisome Proliferator-activated Receptor-γ As A Novel and Promising Target For Treating Cancer Via Regulation of Inflammation: A Brief Review	8
Meet the Editor in Chief	8
Anticancer Potential of Naringenin, Biosynthesis, Molecular Target, and Structural Perspectives	8
Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity	8
Some Scaffolds as Anti-leishmanial Agents: A Review	8
Acknowledgements to Reviewers	8
Recent Development in Substituted Benzothiazole as an Anticonvulsant Agent	8
Modulation of Long Non-coding RNAs by Different Classes of Secondary Metabolites from Plants: A Mini-review on Antitumor Effects	8
Meet the Editorial Board Member	8
Meet the Executive Guest Editor	8
Targeting Bcl-2 with Indole Scaffolds: Emerging Drug Design Strategies for Cancer Treatment	8

PRISMA Based Systematic Review: Pharmacognostic Study of Zanthoxylum armatum DC.	8
Advances in Biocatalytic Synthesis, Pharmacological Activities, Pharmaceutical Preparation and Metabolism of Ginsenoside Rh2	8
Novel Niacin Receptor Agonists: A Promising Strategy for the Treatment of Dyslipidemia	8
Agent in Urgent Need of Clinical Practice: Corilagin	8
Elucidating the Drug Repurposing Spectra of COVID-19 with its Analogues SARS and MERS	8
Protective Effect of Plumeria Pudica Latex Proteins on Intestinal Mucositis Induced by 5-Fluorouracil	8
Recent Advances in Small Molecular PET Tracers for Pancreatic Cancer Diagnosis: Preclinical Stage	7
Novel GABAA Agonist Entities: Pharmacological Investigation and Molecular Modeling Study of Thiazolo- and Thiadiazolo-[3,2-a][1,3]diazepine Analogs	7
Meet the Editorial Board Member	7
The Use of Nanocarriers to Enhance the Anti-neuroinflammatory Potential of Dietary Flavonoids in Animal Models of Neurodegenerative Diseases: A Systematic Review	7
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment	7
Anticancer Natural Products with Collateral Sensitivity: A Review	7
Lyophilization of Molecular Biology Reactions: A Review	7
Systematic Review of the Serotonergic System in the Pathophysiology of Severe Dengue: The Theory of Thrombocytopenia and Vascular Extravasation	7
The Indispensable Roles of GMDS and GMDS-AS1 in the Advancement of Cancer: Fucosylation, Signal Pathway and Molecular Pathogenesis	7
Natural and Synthetic Phosphodiesterase Inhibitors in 2023: an Update on the Impact on Neurological and Psychiatric Conditions	7
ZFPM2-AS1: An Oncogenic Long Non-coding RNA in Multiple Cancer Types	7
LncRNA DSCAM-AS1: A Pivotal Therapeutic Target in Cancer	7
Cathepsin B-A Neuronal Death Mediator in Alzheimer’s Disease Leading to Neurodegeneration	7
Recent Studies on the Pharmacological Activities and Structural Modifications of Compound-K	7
Meet the Editorial Board Member	7
Biological Activities of Morita-Baylis-Hillman Adducts (MBHA)	7
Recent Approaches of Repositioning and Traditional Drugs for the Treatment of COVID-19 Pandemic Outbreak	7
Levothyroxine and Non-alcoholic Fatty Liver Disease: A Mini Review	7
Alzheimer's Disease and Cancer: Common Targets	7
Brassica oleracea var. capitata f. alba: A Review on its Botany, Traditional uses, Phytochemistry and Pharmacological Activities	7
Bioactivities of Dietary Polyphenols and Their Effects on Intestinal Microbiota	7
Recent Progress Towards Vaccines and Antibody-based Therapies Against Alzheimer's Disease	7
Dendrobine: A neuroprotective Sesquiterpenic Alkaloid for the Prevention and Treatment of Diseases: A Review	7
MCM3AP-AS1: A LncRNA Participating in the Tumorigenesis of Cancer Through Multiple Pathways	7
An Updated Review of Various Medicinal Applications of p-Co umaric Acid: From Antioxidative and Anti-Inflammatory Properties to Effects on Cell Cycle and Proliferation	7
Meet the Co-Editor	7
Fungal Endophytes: A Storehouse of Bioactive Compounds	7
A Concise and Useful Guide to Understand How Alpha1 Adrenoceptor Antagonists Work	6
Developments in the Antitumor Activity, Mechanisms of Action, Structural Modifications, and Structure-Activity Relationships of Steroidal Saponins	6
Acknowledgement to Reviewers	6
Osthole: Synthesis, Structural Modifications, and Biological Properties	6
The Role of Renin-Angiotensin System in Diabetic Nephropathy: An Update	6
Mitochondrial Proteins as Metabolic Biomarkers and Sites for Therapeutic Intervention in Primary and Metastatic Cancers	6
Pyridine Moiety: An Insight into Recent Advances in the Treatment of Cancer	6
Research Progress of Tamarixetin and its Glycosides	6
Recent Advances in Fluorescent Probes for G-quadruplex DNAs / RNAs	6
Meet the Associate Editorial Board Member	6
An Updated and Focused Review on Heterocyclic Inhibitors for SARSCoV and SARS-CoV-2 3CLpro	6
Chitosan: Applications in Drug Delivery System	6
1,3,5-Triazine: Recent Development in Synthesis of its Analogs and Biological Profile	6
Gastrointestinal, Liver, Pancreas, Oral and Psychological Long-term Symptoms of COVID-19 After Recovery: A Review	6
The Therapeutic Potential of Purinergic Receptors in Alzheimer’s Disease and Promising Therapeutic Modulators	6
Meet the Editorial Board Member	6
Mini-Review on Vitamin D in Pediatric Population and its Role in Respiratory and Atopic Disorders	6
Dietary Intake of Hydrolyzable Tannins and Condensed Tannins to Regulate Lipid Metabolism	6
A New Mode of Thinfilm and Nanofiber for Burst Release of the Drug for Alzheimer Disease; A Complete Scenario from Dispersible Polymer to Formulation Methodology	6
The Emergence of N. sativa L. as a Green Antifungal Agent	6
Meet the Associate Editorial Board Member	6
Comparative Review of Effects of Pien Tze Huang and AnGong NiuHuang Pill and their Potential on Treatment of Central Nervous System Diseases	6
Role of Caffeine in the Age-related Neurodegenerative Diseases: A Review	6
MicroRNA: A Potential Diagnosis for Male Infertility	6
Nuclear Medicine Application of Pentixafor/Pentixather Targeting CXCR4 for Imaging and Therapy in Related Disease	6
Biodegradable Polymers and their Applications: A Review	6
Exploration of Potent Multi-target-directed-ligands as Anti-alzheimer’s Disease Agents: A Moiety Based Review	6
The Role of Epigenetic Mechanisms in Autoimmune, Neurodegenerative, Cardiovascular, and Imprinting Disorders	6
Phage-choline Kinase Inhibitor Combination to Control Pseudomonas aeruginosa: A Promising Combo	6
Meet the Section Editor	6
Promising Enzymes for Inhibitors Development Against COVID-19	6
Therapeutic Potential of Thiophene Compounds: A Mini-Review	6
The Role of 3'UTR of RNA Viruses on mRNA Stability and Translation Enhancement	6
Effects of Green Tea (−)-Epigallocatechin-3-Gallate (EGCG) on Cardiac Function - A Review of the Therapeutic Mechanism and Potentials	6
Acknowledgements to Reviewers	6
Exploring Genetic Silencing: RNAi and CRISPR-Cas Potential against Drug Resistance in Malaria	6
Selenium and Computational Studies	6
Emerging Role of Terpenoids for the Treatment of Cancer: A Review	6
Tuberculosis, BCG Vaccination, and COVID-19: Are They Connected?	5
Methyl-linked Pyrazoles: Synthetic and Medicinal Perspective	5
The Progress of Small Molecule Targeting BCR-ABL in the Treatment of Chronic Myeloid Leukemia	5
Withdrawal: Advances in Development of Drugs for Chronic Myelogenous Leukemia	5
MiRNAs: Emerging Agents for Therapeutic Effects of Polyphenols on Ovarian Cancer	5
Cytotoxic Activity of Tropane Alkaloides of Species of Erythroxylum	5
A Review and Meta-analysis on Trastuzumab Resistance in Patients with HER2+ Breast Cancer	5
SARS-CoV-2 Infections, Impaired Tissue, and Metabolic Health: Pathophysiology and Potential Therapeutics	5
Research Progress on the Natural Product Aloperine and Its Derivatives	5
Small-Molecule Drugs in Immunotherapy	5
Cyclin-Dependent Kinase 4/6 Inhibitors Against Breast Cancer	5
Meet the Editorial Board Member	5
In silico Approaches for Exploring the Pharmacological Activities of Benzimidazole Derivatives: A Comprehensive Review	5
Acknowledgements to Reviewers	5
Advances in Pyrazole Based Scaffold as Cyclin-dependent Kinase 2 Inhibitors for the Treatment of Cancer	5
Preface	5
Recent Development of DNA Gyrase Inhibitors: An Update	5
Effectiveness of Azithromycin as Add-on Therapy in COVID-19 Management	5
2-Substituted-mercapto-quinazolin-4(3H)-ones as DHFR Inhibitors	5
Meet the Section Editor	5
Antidiabetic Properties of Dietary Chrysin: A Cellular Mechanism Review	5
Recent Progress of Bioactivities, Mechanisms of Action, Total Synthesis, Structural Modifications and Structure-activity Relationships of Indole Derivatives: A Review	5
Nano-biotechnology and its Innovative Perspective in Diabetes Management	5
Emerging Need of Today: Significant Utilization of Various Databases and Softwares in Drug Design and Development	5