Mini-Reviews in Medicinal Chemistry

Article	Citations
A Review on Chemical Structures and Biological Activities of Dopamine Derivatives from Medicinal Insects	61
Comprehensive Update on Synthetic Aspects of Bosentan Derivatives	54
An Insight into the Combat Strategies for the Treatment of Type 2 Diabetes Mellitus	52
Aptamers Against COVID-19: An Untested Opportunity	51
Synthesis of Phenothiazine Derivatives and their Diverse Biological Activities: A Review	50
Ferroptosis Inhibitors as Potential New Therapeutic Targets for Cardiovascular Disease	49
Synthetic Approach to Potential Anticancer Benzimidazole Derivatives: A Review	47
Current Perspective of Synthesis of Medicinally Relevant Benzothiazole based Molecules: Potential for Antimicrobial and Anti-Inflammatory Activities	39
Targeting Lysosomes: A Strategy Against Chemoresistance in Cancer	38
Recent Developments in Tacrine-based Hybrids as a Therapeutic Option for Alzheimer’s Disease	38
Benefits of Manuka Honey in the Management of Infectious Diseases: Recent Advances and Prospects	35
The Role of IL-6 Released During Exercise to Insulin Sensitivity and Muscle Hypertrophy	35
Current Insight on the Role of Glucokinase and Glucokinase Regulatory Protein in Diabetes	34
Antisense Molecules: Design, Chemistry, and Therapeutic Innovations	34
Meet the Editorial Board Member	33
Meet the Editorial Board Member	32
Meet the Editorial Board Member	32
The Critical Function of microRNAs in Developing Resistance against 5- Fluorouracil in Cancer Cells	30
Meet the Editorial Board Member	29
Bioactive Flavonoids: A Comparative Overview of the Biogenetic and Chemical Synthesis Approach	28
Advances in Exercise Therapy in Hemodialysis: A Systematic Review	27
Bioactive Sulfonamides Derived from Amino Acids: Their Synthesis and Pharmacological Activities	27
KRAS Pathway-based Therapeutic Approaches in Pancreatic Cancer	27
Regulatory T Cells: Subtle and Promising Achilles' Heel of Psoriasis - Atherosclerosis Comorbidity	26
Associate Editorial Board Members	25

Irisin and Energy Metabolism and the Role of Irisin on Metabolic Syndrome	25
The most Recent Compilation of Reactions of Enaminone Derivatives with various Amine Derivatives to Generate Biologically Active Compounds	25
Revolutionizing Playing with Skeleton Atoms: Molecular Editing Surgery in Medicinal Chemistry	25
Role of TBK1 Inhibition in Targeted Therapy of Cancer	24
A Review on Acridines as Antiproliferative Agents	24
Recent Advancements in Strategies for Abnormal Protein Clearance in Alzheimer's Disease	24
Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships	24
Recent Advances in Nanobiotechnology for the Treatment of Non-Hodgkin’s Lymphoma	24
Meet the Section Editor	23
Cinnamic Acid Derivatives: Recent Discoveries and Development Strategies for Alzheimer’s Disease	23
The Pivotal Function of SLC16A1 and SLC16A1-AS1 in Cancer Progress: Molecular Pathogenesis and Prognosis	23
Inhibitors of Epigenetic Modulators as Therapeutic Alternatives for Cardiovascular Diseases	23
A Review of the Role of Poly (ADP-Ribose) Polymerase-1 (PARP1) and Its Inhibitors for Cancer Therapy	22
Molecular Insights on the Therapeutic Effect of Selected Flavonoids on Diabetic Neuropathy	21
Inhibitory Activities of Pyrazolo-Oxazine Heterocyclic Derivatives	21
Research Progress in Alpha-fetoprotein-induced Immunosuppression of Liver Cancer	21
Psilocybin: Chemical Foundations and Emerging Therapeutic Potential	21
Pharmacological Efficacy and Safety of Glycyrrhiza glabra in the Treatment of Respiratory Tract Infections	20
Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor- Kappa B (NF-kB) Inhibitors	20
Natural Products with BACE1 and GSK3β Inhibitory Activity	19
AGAP2-AS1: An Indispensable lncRNA in Tumors	19
Meet the Frontiers Section Editor	19
Meet the Editorial Board Member	19
The Role of MiR-29 in the Mechanism of Fibrosis	19
Exploring the Therapeutic Potential of Green Tea (Camellia sinensis L.) in Anti-Aging: A Comprehensive Review of Mechanisms and Findings	18
Breaking Barriers in Breast Cancer: Multi-Targeted Therapeutic Insights	18
Research Hotspots and Trends of Artificial Intelligence in Drug Discovery: A Review and Bibliometric Analysis	17
Natural Products as Autophagy-related Protein Kinase Inhibitors: A Future Promising Anticancer from Nature	17
Critical Relationship Between Iron Deficiency Anaemia (IDA) and Glycated Haemoglobin (HbA1c): An Updated Review	17
Physicochemical Properties, Drug Delivery, and Tissue Engineering Applications of Neem Gum and Its Derivatives: A Comprehensive Review	17
Marine-Derived Fucoidan in Cancer Therapy: Mechanistic Insights, Clinical Prospects, and Future Directions	17
The Utilization and Development of Viral Vectors in Vaccines as a Prophylactic Treatment Against Ebola Virus as an Emerging and Zoonotic Infectious Disease	16
Quinoline Derivatives as Promising Scaffolds for Antitubercular Activity: A Comprehensive Review	16
Green-synthesized titanium dioxide nanoparticles: systematic review of antimicrobial efficacy and biocompatibility	16
Current Status of and Perspectives on Radiolabelled Ubiquicidin 29-41 Derivatives for Bacterial Infection Imaging	16
Roles of Accelerated Molecular Dynamics Simulations in Predictions of Binding Kinetic Parameters	16
The Effects of Increased Glucose Level and Glycolysis on SARS CoV-2 Infection	16
Meet the Editorial Board Member	16
Recent Literature on the Synthesis of Thiazole Derivatives and their Biological Activities	16
Innovative Approaches to Alzheimer's Treatment: Utilizing Tacrine Hybrids to Inhibit Amyloid Beta Aggregation as a Strategic Focus	15
MicroRNAs and Efferocytosis: Implications for Diagnosis and Therapy	15
Development of Mycobacterium tuberculosis Enoyl Acyl Reductase (InhA) Inhibitors: A Mini-Review	15
Meet the Editorial Board Member	15
Homometallic Polynuclear Rhodium Complexes in Anticancer Drug Development	15
The Art and Science of Antidiabetic Medications and Obesity Management	15
Flavonoid-metal ion Complexes as Potent Anticancer Metallodrugs: A Comprehensive Review	15
Development of Triazole based Anticonvulsants through Various Catalytic Approaches	15
N-Methyl-D-Aspartate (NMDA)-Type Glutamate Receptors and Demyelinating Disorders: A Neuroimmune Perspective	15
Drug Repurposing: A Conduit to Unravelling Metabolic Reprogramming for Cancer Treatment	15
Natural Products, Synthesis, and Biological Activities of Quinolines (2020-2024)	15

Nimbolide: A Potential Phytochemical Agent in Multimodal Pancreatic Cancer Therapies	15
Strategies in Taxol Development: A Review	14
Meet the Editor-in-Chief	14
Comprehensive Insight into Green Synthesis Approaches, Structural Activity Relationship, and Therapeutic Potential of Pyrazolic Chalcone Derivative	14
Recent Updates on Sinularia Soft Coral	14
Meet the Editorial Board Member	14
Chemical Strategies Toward Prodrugs and Fluorescent Probes for Gasotransmitters	14
Potential of Small Molecule TAAR-1 Agonists for the Therapy of Neurodegenerative Psychosis: A Medicinal Chemistry Perspective	14
Inhibitors Targeting Hepatitis C Virus (HCV) Entry	14
Meet the Editorial Board Member	14
Meet the Editorial Board Member	14
A Comprehensive Review on Chemistry and Biology of Tafamidis in Transthyretin Amyloidosis	14
The Complex Roles of DNA Repair Pathways, Inhibitors, Hyperthermia, and Contact Inhibition in Cell Cycle Halts	14
Therapeutic Potentials of Aconite-like Alkaloids: Bioinformatics and Experimental Approaches	14
Meet the Editorial Board Member	13
Uncovering the Potential of Lipid Drugs: A Focus on Transient Membrane Microdomain-targeted Lipid Therapeutics	13
An Overview of Pyridazinone Analogs: Chemical and Pharmacological Potential	13
A Critical Observation on the Design and Development of Reported Peptide Inhibitors of DENV NS2B-NS3 Protease in the Last Two Decades	13
Meet the Editorial Board Member	13
Meet the Editorial Board Member	13
Meet the Editorial Board Member	13
The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex® - A Cannabis-derived Spray	12
The Search for Antidotes Against Ricin	12
Use of Chitosan as a Precursor for Multiple Applications in Medicinal Chemistry: Recent Significant Contributions	12
Second-line Therapy for Helicobacter Pylori Eradication: State of the Art	12
Nuclei-targeted Therapeutic Delivery: A Novel Concept for the Treatment of Cancer	12
In vivo Pharmacokinetic and ADMET Profiles of Synthetic Antimicrobial Peptides (AMPs)	12
Indole-3-carbinol (I3C) as Leukemia Therapeutic Agents: Review	12
Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing	12
Chemistry, Analysis, and Biological Aspects of Daprodustat, A New Hypoxia Inducible Factor Prolyl Hydroxylase Inhibitor: A Comprehensive Review	12
A Therapeutic Journey of Potential Drugs Against COVID-19	12
Melatonin and Related Compounds as Antioxidants	12
Chlorogenic Acid Derivatives: Structural Modifications, Drug Design, and Biological Activities: A Review	12
Therapeutic Approaches for the Treatment of Interstitial Lung Disease: An Exploratory Review on Molecular Mechanisms	12
The Application of the Pyrazole Structure in the Structural Modification of Natural Products	12
Energy Metabolism Behavior and Response to Microenvironmental Factors of the Experimental Cancer Cell Models Differ from that of Actual Human Tumors	12
Narrative Review of the Pharmacodynamics, Pharmacokinetics, and Toxicities of Illicit Synthetic Cannabinoid Receptor Agonists	11
New Insights into the Modifications and Bioactivities of Indole-3- Carboxaldehyde and its Derivatives as a Potential Scaffold for Drug Design: A Mini-Review	11
Recent Insights of Metformin on Hepatocellular Carcinoma (HCC)	11
Meet the Editorial Board Member	11
Cardiovascular Effects of Ruthenium Complexes: A Potential Therapeutic Tool in Hypertension and Myocardial Injury	11
Anthriscus sylvestris: An overview on Bioactive Compounds and Anticancer Mechanisms from a Traditional Medicinal Plant to Modern Investigation	11
Exploring the Versatility of Azine Derivatives: A Comprehensive Review on Synthesis and Biological Applications	11
Aloe-emodin: Progress in Pharmacological Activity, Safety, and Pharmaceutical Formulation Applications	11
Protective Effect of Plumeria Pudica Latex Proteins on Intestinal Mucositis Induced by 5-Fluorouracil	11
The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases	11
Nutraceuticals, a Bridge Between Past and Future: Focus on Mushrooms Biological Activities and Myco-Chemistry	11
The Role of Genetics and Synergistic Effect of Targeting Common Genetic Mutations in Acute Lymphoblastic Leukemia (ALL)	11
Recent Advancements and SAR Studies of Synthetic Coumarins as MAO-B Inhibitors: An Updated Review	11
Research Progress in Mutagenesis Techniques for Aspergillus fumigatus and the Biological Activities of Fumagillin	11
Targeting Bcl-2 with Indole Scaffolds: Emerging Drug Design Strategies for Cancer Treatment	10
Synthesis and Biological Properties of Isatin-indole Hybrids: A Review	10
Meet the Editor in Chief	10
Nicotinamide Adenine Dinucleotide in the Development and Treatment of Cardiac Remodeling and Aging	10
A Short Review on Glucogallin and its Pharmacological Activities	10
Meet the Editorial Board Member	10
Meet the Editorial Board Member	10
Modulation of Long Non-coding RNAs by Different Classes of Secondary Metabolites from Plants: A Mini-review on Antitumor Effects	10
Recent Development of CXCR4-Targeted Nuclear Medicine Research in Adrenocortical Tumors	10
Meet the Co-Editor	10
Agent in Urgent Need of Clinical Practice: Corilagin	10
Natural Product-based Therapies for Inflammatory Bowel Disease: Targeting Key Signaling Pathways	9
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment	9
The Use of Nanocarriers to Enhance the Anti-neuroinflammatory Potential of Dietary Flavonoids in Animal Models of Neurodegenerative Diseases: A Systematic Review	9
Fungal Endophytes: A Storehouse of Bioactive Compounds	9
Breast Cancer: Challenges in the Treatment and Prodrug Strategies	9
The Indispensable Roles of GMDS and GMDS-AS1 in the Advancement of Cancer: Fucosylation, Signal Pathway and Molecular Pathogenesis	9
Levothyroxine and Non-alcoholic Fatty Liver Disease: A Mini Review	9
Systematic Review of the Serotonergic System in the Pathophysiology of Severe Dengue: The Theory of Thrombocytopenia and Vascular Extravasation	9
Natural and Synthetic Phosphodiesterase Inhibitors in 2023: an Update on the Impact on Neurological and Psychiatric Conditions	9
Recent Advances in Small Molecular PET Tracers for Pancreatic Cancer Diagnosis: Preclinical Stage	9
MCM3AP-AS1: A LncRNA Participating in the Tumorigenesis of Cancer Through Multiple Pathways	9
Bioactivities of Dietary Polyphenols and Their Effects on Intestinal Microbiota	8
Dendrobine: A neuroprotective Sesquiterpenic Alkaloid for the Prevention and Treatment of Diseases: A Review	8
Acknowledgements to Reviewers	8
Meet the Associate Editorial Board Member	8
LncRNA DSCAM-AS1: A Pivotal Therapeutic Target in Cancer	8
Minoxidil as a Prodrug: Review of Chemical, Pharmacological, and Technological Aspects in Alopecia Therapeutics	8
Recent Studies on the Pharmacological Activities and Structural Modifications of Compound-K	8
Biological Activities of Morita-Baylis-Hillman Adducts (MBHA)	8

Meet the Editorial Board Member	8
Acknowledgement to Reviewers	8
Cathepsin B-A Neuronal Death Mediator in Alzheimer’s Disease Leading to Neurodegeneration	8
Lyophilization of Molecular Biology Reactions: A Review	8
Naturally occurring and synthetic coumarin derivatives: Promising agents for managing neuroinflammation	8
Meet the Associate Editorial Board Member	8
An Updated and Focused Review on Heterocyclic Inhibitors for SARSCoV and SARS-CoV-2 3CLpro	8
A Concise and Useful Guide to Understand How Alpha1 Adrenoceptor Antagonists Work	7
Therapeutic Potential of Thiophene Compounds: A Mini-Review	7
Mini-Review on Vitamin D in Pediatric Population and its Role in Respiratory and Atopic Disorders	7
The Emergence of N. sativa L. as a Green Antifungal Agent	7
Meet the Section Editor	7
The Roles, Mechanisms, and Clinical Significance of Long Non-coding RNA MSC-AS1 in Cancer	7
Exploring Genetic Silencing: RNAi and CRISPR-Cas Potential against Drug Resistance in Malaria	7
Gastrointestinal, Liver, Pancreas, Oral and Psychological Long-term Symptoms of COVID-19 After Recovery: A Review	7
Exploring Tetrahydroisoquinoline (THIQ) Scaffold as Therapeutic Modulators of Sigma Receptors	7
Phage-choline Kinase Inhibitor Combination to Control Pseudomonas aeruginosa: A Promising Combo	7
Dietary Intake of Hydrolyzable Tannins and Condensed Tannins to Regulate Lipid Metabolism	7
Meet the Editorial Board Member	7
Alzheimer's Disease and Cancer: Common Targets	7
Research Progress of Tamarixetin and its Glycosides	7
The Role of Renin-Angiotensin System in Diabetic Nephropathy: An Update	7
ZFPM2-AS1: An Oncogenic Long Non-coding RNA in Multiple Cancer Types	7
Effects of Green Tea (−)-Epigallocatechin-3-Gallate (EGCG) on Cardiac Function - A Review of the Therapeutic Mechanism and Potentials	7
Mitochondria as a Therapeutic Target in Metabolic Disorders	7
The Role of Epigenetic Mechanisms in Autoimmune, Neurodegenerative, Cardiovascular, and Imprinting Disorders	7
Innovations in Biosensing Technologies for Cancer Diagnosis and Theranostics	7
Comparative Review of Effects of Pien Tze Huang and AnGong NiuHuang Pill and their Potential on Treatment of Central Nervous System Diseases	7
Recent Advances in Fluorescent Probes for G-quadruplex DNAs / RNAs	7
Role of Caffeine in the Age-related Neurodegenerative Diseases: A Review	7
Immune Cells in the Tumor Microenvironment: Mechanisms of Immune Resistance and Therapeutic Advances	7
Cyclin-Dependent Kinase 4/6 Inhibitors Against Breast Cancer	6
Withdrawal: Advances in Development of Drugs for Chronic Myelogenous Leukemia	6
Osthole: Synthesis, Structural Modifications, and Biological Properties	6
Biodegradable Polymers and their Applications: A Review	6
MiRNAs: Emerging Agents for Therapeutic Effects of Polyphenols on Ovarian Cancer	6
Nuclear Medicine Application of Pentixafor/Pentixather Targeting CXCR4 for Imaging and Therapy in Related Disease	6
The Progress of Small Molecule Targeting BCR-ABL in the Treatment of Chronic Myeloid Leukemia	6
Chitosan: Applications in Drug Delivery System	6
Meet the Section Editor	6
Developments in the Antitumor Activity, Mechanisms of Action, Structural Modifications, and Structure-Activity Relationships of Steroidal Saponins	6
Acknowledgements to Reviewers	6
Emerging Role of Dendrobium Orchid Plants in Diabetes: Phytochemistry Aspects, SAR, and Therapeutic Potential	6
Marine-derived Bioactive Compounds: A Promising Frontier against Multidrug-resistant Microbial Infections	6
Recent Progress of Bioactivities, Mechanisms of Action, Total Synthesis, Structural Modifications and Structure-activity Relationships of Indole Derivatives: A Review	6
In silico Approaches for Exploring the Pharmacological Activities of Benzimidazole Derivatives: A Comprehensive Review	6
Meet the Editorial Board Member	6
1,3,5-Triazine: Recent Development in Synthesis of its Analogs and Biological Profile	6
Medicinal Chemistry of Fourth-generation Tyrosine Kinase Inhibitors	6
Mitochondrial Proteins as Metabolic Biomarkers and Sites for Therapeutic Intervention in Primary and Metastatic Cancers	6
Antidiabetic Properties of Dietary Chrysin: A Cellular Mechanism Review	6
Unraveling the Multifunctional Therapeutic Potential of Topsentin: A Marine-derived Versatile Scaffold	6
The Multifaceted Potential of Adhatoda vasica Nees: Traditional Uses, Pharmacological Activities and Biotechnological Applications	6
HDAC9 as a Privileged Target: Reviewing its Role in Different Diseases and Structure-activity Relationships (SARs) of its Inhibitors	5
Exploring the Potential of Anacardic Acid, its Natural and Synthetic Analogues, and Nanoformulations as a Potential Antibacterial Agent, including Multidrug-Resistant Bacteria: A Comprehensive Review	5
Meet the Editorial Board Member	5
Recent Advances in the Therapeutic Prospective of Heterocyclic Derivatives as COX-2 Inhibitors (2019-Present)	5
Molecular Targets for Chalcones in Antileishmanial Drug Discovery	5
Small-Molecule Drugs in Immunotherapy	5
Insight in Quinazoline-based HDAC Inhibitors as Anti-cancer Agents	5
Recent Advances in PI3 Kinase Inhibitors: Anticancer Activities and Structure-Activity Relationships	5
Recent Development of DNA Gyrase Inhibitors: An Update	5
Advances in Pyrazole Based Scaffold as Cyclin-dependent Kinase 2 Inhibitors for the Treatment of Cancer	5
MicroRNAs in Various Body Fluids and their Importance in Forensic Medicine	5
An In Silico Approach to Exploring the Antinociceptive Biological Activities of Linalool and its Metabolites	5
The Immune Response to SARS-CoV-2: Mechanisms, Aging, Sequelae, and Vaccines	5
Meet the Editorial Board Member	5
Research and Progress of Probucol in Nonalcoholic Fatty Liver Disease	5
The Recent Developments of ADCs with the Tubulysins as the Payloads	5
Research Progress of Diterpenoids with Potential Antidiabetic Activity	5
Tuberculosis, BCG Vaccination, and COVID-19: Are They Connected?	5
Anti-Tubercular Activity of Pyrazinamide Conjugates: Synthesis and Structure-Activity Relationship Studies	5
Perspectives on Agmatine Neurotransmission in Acute and Chronic Stressrelated Conditions	5
A Review and Meta-analysis on Trastuzumab Resistance in Patients with HER2+ Breast Cancer	5
Advances in the Development of Non-Structural Protein 1 (NsP1) Inhibitors for the Treatment of Chikungunya Virus Infection	5
Potential of MAO-B Inhibitors with Multi-target Inhibition and Antioxidant Properties for the Treatment of Neurodegenerative Disorders	5
Meet the Editorial Board Member	5
Preface	5
Innovative Theranostics Strategies in the Fight Against Lung Cancer	5
Optical Biosensors: A Comprehensive Review of Their Applications in Photoplethysmography, Environmental Monitoring, and Medical Diagnostics	5
Tanshinone IIA Against Cerebral Ischemic Stroke and Ischemia- Reperfusion Injury: A Review of the Current Documents	5
SARS-CoV-2 Infections, Impaired Tissue, and Metabolic Health: Pathophysiology and Potential Therapeutics	5
Preface	5
Nanotechnology Meets Phytotherapy: A Comprehensive Review of Berberine in Cancer	5
An Outline on Benzimidazole Containing Marketed Drugs with Proton Pump Inhibitor and H1 Receptor Antagonist Activities	5
Therapeutic and Pharmacological flexibility of Cinnamoyl Compounds: Targeting Multiple Signaling Pathways	4
An Overview of Treatment Guidelines and Methods of Synthesis of Drugs Used in Leprosy Chemotherapy	4
Centrosome Clustering & Chemotherapy	4
In vivo Acute Anti-Inflammatory Activity of Essential Oils: A Review	4
Triterpenoid Compounds and their Derivatives: Emerging Pharmacological Agents for Arthritis Treatment	4
The Medicinal Chemistry of Chalcones as Anti-Mycobacterium tuberculosis Agents	4
Potential of Nature-derived Biopolymers for Oral Applications- A Mini-Review	4
Advances in Fragment-based Drug Design: Lessons and Innovations from the Post-COVID Drug Discovery Landscape	4
Polychlorinated Biphenyls: A Review of Recent Updates on Food Safety and Environmental Monitoring, Health and Toxicological Implications, and Analysis	4
Exploration of Schiff Bases: Structures, Syntheses, and Biological Activities	4