Mini-Reviews in Medicinal Chemistry

Article	Citations
Targeting Lysosomes: A Strategy Against Chemoresistance in Cancer	115
A Review on Chemical Structures and Biological Activities of Dopamine Derivatives from Medicinal Insects	76
Protein and Small-Molecule Leucopoiesis and Thrombopoiesis Stimulators	73
Natural Products Databases for Drug Design	60
An Insight into the Combat Strategies for the Treatment of Type 2 Diabetes Mellitus	52
A Review on Rotenoids: Purification, Characterization and its Biological Applications	50
Current Perspective of Synthesis of Medicinally Relevant Benzothiazole based Molecules: Potential for Antimicrobial and Anti-Inflammatory Activities	49
Current Insight on the Role of Glucokinase and Glucokinase Regulatory Protein in Diabetes	46
Comprehensive Update on Synthetic Aspects of Bosentan Derivatives	45
Aptamers Against COVID-19: An Untested Opportunity	44
Recent Developments in Tacrine-based Hybrids as a Therapeutic Option for Alzheimer’s Disease	43
Multitarget Directed Ligand Approaches for Alzheimer’s Disease: A Comprehensive Review	42
Synthetic Approach to Potential Anticancer Benzimidazole Derivatives: A Review	41
Quinoxaline: A Chemical Moiety with Spectrum of Interesting Biological Activities	40
Benefits of Manuka Honey in the Management of Infectious Diseases: Recent Advances and Prospects	40
Multi-Target Drug Design of Anti-Alzheimer’s Disease based on Tacrine	39
The Role of IL-6 Released During Exercise to Insulin Sensitivity and Muscle Hypertrophy	36
Ferroptosis Inhibitors as Potential New Therapeutic Targets for Cardiovascular Disease	36
Synthesis of Phenothiazine Derivatives and their Diverse Biological Activities: A Review	35
Meet the Editorial Board Member	34
Meet the Editorial Board Member	34
Meet the Editorial Board Member	33
The most Recent Compilation of Reactions of Enaminone Derivatives with various Amine Derivatives to Generate Biologically Active Compounds	33
Irisin and Energy Metabolism and the Role of Irisin on Metabolic Syndrome	32
Bioactive Flavonoids: A Comparative Overview of the Biogenetic and Chemical Synthesis Approach	31

Chemotherapeutic Strategies for Combating Staphylococcus aureus Infections	31
Meet the Editorial Board Member	30
Advances in Exercise Therapy in Hemodialysis: A Systematic Review	28
Anticancer Potential of Coumarin and its Derivatives	27
The Critical Function of microRNAs in Developing Resistance against 5- Fluorouracil in Cancer Cells	27
KRAS Pathway-based Therapeutic Approaches in Pancreatic Cancer	27
Bioactive Sulfonamides Derived from Amino Acids: Their Synthesis and Pharmacological Activities	27
Recent Advances in Natural Products with Antiviral Activities	26
Revolutionizing Playing with Skeleton Atoms: Molecular Editing Surgery in Medicinal Chemistry	26
Meet the Editorial Board Member	25
Cinnamic Acid Derivatives: Recent Discoveries and Development Strategies for Alzheimer’s Disease	25
Associate Editorial Board Members	25
Role of TBK1 Inhibition in Targeted Therapy of Cancer	24
Recent Advancements in Strategies for Abnormal Protein Clearance in Alzheimer's Disease	23
Meet the Section Editor	23
Inhibitory Activities of Pyrazolo-Oxazine Heterocyclic Derivatives	23
Natural Products with BACE1 and GSK3β Inhibitory Activity	22
Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships	22
Ferulic Acid and Cardiovascular Health: Therapeutic and Preventive Potential	21
Pharmacological Efficacy and Safety of Glycyrrhiza glabra in the Treatment of Respiratory Tract Infections	21
The Pivotal Function of SLC16A1 and SLC16A1-AS1 in Cancer Progress: Molecular Pathogenesis and Prognosis	20
Antioxidant, Anti-inflammatory, Antibacterial, and Analgesic Activities and Mechanisms of Quinolines, Indoles and Related Derivatives	20
A Review on Acridines as Antiproliferative Agents	20
Molecular Insights on the Therapeutic Effect of Selected Flavonoids on Diabetic Neuropathy	20
Recent Advances in Nanobiotechnology for the Treatment of Non-Hodgkin’s Lymphoma	19
Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor- Kappa B (NF-kB) Inhibitors	19
Research Progress in Alpha-fetoprotein-induced Immunosuppression of Liver Cancer	19
The Role of MiR-29 in the Mechanism of Fibrosis	19
Roles of Accelerated Molecular Dynamics Simulations in Predictions of Binding Kinetic Parameters	18
Recent Literature on the Synthesis of Thiazole Derivatives and their Biological Activities	18
Meet the Frontiers Section Editor	18
A Critical Review on Recent Development of Techniques and Drug Targets in the Management of Breast Cancer	18
Drug Solubilization by Surfactants: Experimental Methods and Theoretical Perspectives	18
Meet the Editorial Board Member	18
Carbohydrazide Analogues: A Review of Synthesis and Biological Activities	18
AGAP2-AS1: An Indispensable lncRNA in Tumors	18
Meet the Editorial Board Member	18
Meet the Editorial Board Member	17
Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?	17
Exploring the Therapeutic Potential of Green Tea (Camellia sinensis L.) in Anti-Aging: A Comprehensive Review of Mechanisms and Findings	17
Nimbolide: A Potential Phytochemical Agent in Multimodal Pancreatic Cancer Therapies	17
Quinoline Derivatives as Promising Scaffolds for Antitubercular Activity: A Comprehensive Review	17
Development of Mycobacterium tuberculosis Enoyl Acyl Reductase (InhA) Inhibitors: A Mini-Review	16
Flavonoid-metal ion Complexes as Potent Anticancer Metallodrugs: A Comprehensive Review	16
MicroRNAs and Efferocytosis: Implications for Diagnosis and Therapy	16
Recent Advances in the Development of Type 2 Sodium-Glucose Cotransporter Inhibitors for the Treatment of Type 2 Diabetes Mellitus	16
SET Protein in Cancer: A Potential Therapeutic Target	16
Current Status of and Perspectives on Radiolabelled Ubiquicidin 29-41 Derivatives for Bacterial Infection Imaging	16
The Effects of Increased Glucose Level and Glycolysis on SARS CoV-2 Infection	16
Adhatoda vasica (Nees.): A Review on its Botany, Traditional uses, Phytochemistry, Pharmacological Activities and Toxicity	15

Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships	15
Curcumin: An Insight into Molecular Pathways Involved in Anticancer Activity	15
The Utilization and Development of Viral Vectors in Vaccines as a Prophylactic Treatment Against Ebola Virus as an Emerging and Zoonotic Infectious Disease	15
Drug Repurposing: A Conduit to Unravelling Metabolic Reprogramming for Cancer Treatment	15
N-Methyl-D-Aspartate (NMDA)-Type Glutamate Receptors and Demyelinating Disorders: A Neuroimmune Perspective	15
A Comprehensive Review on Chemistry and Biology of Tafamidis in Transthyretin Amyloidosis	14
Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi	14
Meet the Editorial Board Member	14
Meet the Editorial Board Member	14
Meet the Editor-in-Chief	14
Comprehensive Insight into Green Synthesis Approaches, Structural Activity Relationship, and Therapeutic Potential of Pyrazolic Chalcone Derivative	14
Meet the Editorial Board Member	14
Meet the Editorial Board Member	14
Chemical Strategies Toward Prodrugs and Fluorescent Probes for Gasotransmitters	14
Recent Updates on Sinularia Soft Coral	14
Glycyrrhizin as a Potential Treatment for the Novel Coronavirus (COVID-19)	13
Human Galectin-1 in Multiple Cancers: A Privileged Molecular Target in Oncology	13
Meet the Editorial Board Member	13
Strategies in Taxol Development: A Review	13
Inhibitors Targeting Hepatitis C Virus (HCV) Entry	13
Effects of Urtica dioica on Metabolic Profiles in Type 2 Diabetes: A Systematic Review and Meta-analysis of Clinical Trials	13
Therapeutic Potentials of Aconite-like Alkaloids: Bioinformatics and Experimental Approaches	13
Overview of the Biological Activities of Pyrimido[4,5-d]pyrimidines	13
An Overview of Pyridazinone Analogs: Chemical and Pharmacological Potential	13
The Complex Roles of DNA Repair Pathways, Inhibitors, Hyperthermia, and Contact Inhibition in Cell Cycle Halts	13
Meet the Editorial Board Member	12
The Search for Antidotes Against Ricin	12
Chemistry, Analysis, and Biological Aspects of Daprodustat, A New Hypoxia Inducible Factor Prolyl Hydroxylase Inhibitor: A Comprehensive Review	12
Melatonin and Related Compounds as Antioxidants	12
The Situation of Small Molecules Targeting Key Proteins in combatting SARS-CoV-2: Synthesis, Metabolic Pathway, Mechanism of Action, and Potential Therapeutic Applications	12
A Therapeutic Journey of Potential Drugs Against COVID-19	12
Meet the Editorial Board Member	12
Indole-3-carbinol (I3C) as Leukemia Therapeutic Agents: Review	12
Energy Metabolism Behavior and Response to Microenvironmental Factors of the Experimental Cancer Cell Models Differ from that of Actual Human Tumors	12
Chlorogenic Acid Derivatives: Structural Modifications, Drug Design, and Biological Activities: A Review	12
Uncovering the Potential of Lipid Drugs: A Focus on Transient Membrane Microdomain-targeted Lipid Therapeutics	12
Meet the Editorial Board Member	12
Second-line Therapy for Helicobacter Pylori Eradication: State of the Art	12
The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex® - A Cannabis-derived Spray	12
Therapeutic Approaches for the Treatment of Interstitial Lung Disease: An Exploratory Review on Molecular Mechanisms	12
Radical Releasing Anti-tuberculosis Agents and the Treatment of Mycobacterial Tuberculosis Infections - An Overview	11
Role of Cathepsin B in Cancer Progression: A Potential Target for Coordination Compounds	11
Xanthone: Potential Acetylcholinesterase Inhibitor for Alzheimer's Disease Treatment	11
Nutraceuticals, a Bridge Between Past and Future: Focus on Mushrooms Biological Activities and Myco-Chemistry	11
Exploring the Versatility of Azine Derivatives: A Comprehensive Review on Synthesis and Biological Applications	11
The Role of Genetics and Synergistic Effect of Targeting Common Genetic Mutations in Acute Lymphoblastic Leukemia (ALL)	11
The Application of the Pyrazole Structure in the Structural Modification of Natural Products	11
Use of Chitosan as a Precursor for Multiple Applications in Medicinal Chemistry: Recent Significant Contributions	11
Nuclei-targeted Therapeutic Delivery: A Novel Concept for the Treatment of Cancer	11
Narrative Review of the Pharmacodynamics, Pharmacokinetics, and Toxicities of Illicit Synthetic Cannabinoid Receptor Agonists	11
Anthriscus sylvestris: An overview on Bioactive Compounds and Anticancer Mechanisms from a Traditional Medicinal Plant to Modern Investigation	11
In vivo Pharmacokinetic and ADMET Profiles of Synthetic Antimicrobial Peptides (AMPs)	11
A Critical Observation on the Design and Development of Reported Peptide Inhibitors of DENV NS2B-NS3 Protease in the Last Two Decades	11
A Review on a Medicinal and Edible Plant: Aralia elata (Miq.) Seem.	11
Novel Niacin Receptor Agonists: A Promising Strategy for the Treatment of Dyslipidemia	11
Recent Insights of Metformin on Hepatocellular Carcinoma (HCC)	11
Acknowledgements to Reviewers	10
Recent Advancements and SAR Studies of Synthetic Coumarins as MAO-B Inhibitors: An Updated Review	10
The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases	10
Nicotinamide Adenine Dinucleotide in the Development and Treatment of Cardiac Remodeling and Aging	10
A Short Review on Glucogallin and its Pharmacological Activities	10
Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity	10
New Insights into the Modifications and Bioactivities of Indole-3- Carboxaldehyde and its Derivatives as a Potential Scaffold for Drug Design: A Mini-Review	10
Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing	10
Protective Effect of Plumeria Pudica Latex Proteins on Intestinal Mucositis Induced by 5-Fluorouracil	10
Targeting Bcl-2 with Indole Scaffolds: Emerging Drug Design Strategies for Cancer Treatment	10
Modulation of Long Non-coding RNAs by Different Classes of Secondary Metabolites from Plants: A Mini-review on Antitumor Effects	10
Agent in Urgent Need of Clinical Practice: Corilagin	10
Some Scaffolds as Anti-leishmanial Agents: A Review	10
Aloe-emodin: Progress in Pharmacological Activity, Safety, and Pharmaceutical Formulation Applications	10
Antioxidant Activity of 1,2,4-Triazole and its Derivatives: A Mini-Review	10
Meet the Editorial Board Member	10
Anticancer Potential of Naringenin, Biosynthesis, Molecular Target, and Structural Perspectives	10
Peroxisome Proliferator-activated Receptor-γ As A Novel and Promising Target For Treating Cancer Via Regulation of Inflammation: A Brief Review	10
Meet the Editorial Board Member	9
Meet the Editorial Board Member	9
The Indispensable Roles of GMDS and GMDS-AS1 in the Advancement of Cancer: Fucosylation, Signal Pathway and Molecular Pathogenesis	9
Biological Activities of Morita-Baylis-Hillman Adducts (MBHA)	9
Cathepsin B-A Neuronal Death Mediator in Alzheimer’s Disease Leading to Neurodegeneration	9
MCM3AP-AS1: A LncRNA Participating in the Tumorigenesis of Cancer Through Multiple Pathways	9

Meet the Executive Guest Editor	9
Meet the Co-Editor	9
Recent Studies on the Pharmacological Activities and Structural Modifications of Compound-K	9
Natural and Synthetic Phosphodiesterase Inhibitors in 2023: an Update on the Impact on Neurological and Psychiatric Conditions	9
Elucidating the Drug Repurposing Spectra of COVID-19 with its Analogues SARS and MERS	9
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment	9
Advances in Biocatalytic Synthesis, Pharmacological Activities, Pharmaceutical Preparation and Metabolism of Ginsenoside Rh2	9
Meet the Editor in Chief	9
An Updated Review of Various Medicinal Applications of p-Co umaric Acid: From Antioxidative and Anti-Inflammatory Properties to Effects on Cell Cycle and Proliferation	9
Recent Progress Towards Vaccines and Antibody-based Therapies Against Alzheimer's Disease	9
Levothyroxine and Non-alcoholic Fatty Liver Disease: A Mini Review	9
Systematic Review of the Serotonergic System in the Pathophysiology of Severe Dengue: The Theory of Thrombocytopenia and Vascular Extravasation	9
PRISMA Based Systematic Review: Pharmacognostic Study of Zanthoxylum armatum DC.	9
Research Progress of Tamarixetin and its Glycosides	8
Meet the Associate Editorial Board Member	8
Meet the Editorial Board Member	8
Bioactivities of Dietary Polyphenols and Their Effects on Intestinal Microbiota	8
Meet the Section Editor	8
Brassica oleracea var. capitata f. alba: A Review on its Botany, Traditional uses, Phytochemistry and Pharmacological Activities	8
Acknowledgement to Reviewers	8
Recent Advances in Small Molecular PET Tracers for Pancreatic Cancer Diagnosis: Preclinical Stage	8
The Role of 3'UTR of RNA Viruses on mRNA Stability and Translation Enhancement	8
Recent Advances in Fluorescent Probes for G-quadruplex DNAs / RNAs	8
Acknowledgements to Reviewers	8
LncRNA DSCAM-AS1: A Pivotal Therapeutic Target in Cancer	8
Therapeutic Potential of Thiophene Compounds: A Mini-Review	8
Lyophilization of Molecular Biology Reactions: A Review	8
Alzheimer's Disease and Cancer: Common Targets	8
Pyridine Moiety: An Insight into Recent Advances in the Treatment of Cancer	8
Dendrobine: A neuroprotective Sesquiterpenic Alkaloid for the Prevention and Treatment of Diseases: A Review	8
Role of Caffeine in the Age-related Neurodegenerative Diseases: A Review	8
ZFPM2-AS1: An Oncogenic Long Non-coding RNA in Multiple Cancer Types	8
An Updated and Focused Review on Heterocyclic Inhibitors for SARSCoV and SARS-CoV-2 3CLpro	8
Meet the Associate Editorial Board Member	8
Fungal Endophytes: A Storehouse of Bioactive Compounds	8
Exploring Tetrahydroisoquinoline (THIQ) Scaffold as Therapeutic Modulators of Sigma Receptors	8
The Role of Renin-Angiotensin System in Diabetic Nephropathy: An Update	8
The Use of Nanocarriers to Enhance the Anti-neuroinflammatory Potential of Dietary Flavonoids in Animal Models of Neurodegenerative Diseases: A Systematic Review	8
Dietary Intake of Hydrolyzable Tannins and Condensed Tannins to Regulate Lipid Metabolism	8
The Emergence of N. sativa L. as a Green Antifungal Agent	8
Comparative Review of Effects of Pien Tze Huang and AnGong NiuHuang Pill and their Potential on Treatment of Central Nervous System Diseases	8
A New Mode of Thinfilm and Nanofiber for Burst Release of the Drug for Alzheimer Disease; A Complete Scenario from Dispersible Polymer to Formulation Methodology	7
Emerging Role of Terpenoids for the Treatment of Cancer: A Review	7
Gastrointestinal, Liver, Pancreas, Oral and Psychological Long-term Symptoms of COVID-19 After Recovery: A Review	7
Withdrawal: Advances in Development of Drugs for Chronic Myelogenous Leukemia	7
Exploring Genetic Silencing: RNAi and CRISPR-Cas Potential against Drug Resistance in Malaria	7
Meet the Editorial Board Member	7
Selenium and Computational Studies	7
Mini-Review on Vitamin D in Pediatric Population and its Role in Respiratory and Atopic Disorders	7
A Concise and Useful Guide to Understand How Alpha1 Adrenoceptor Antagonists Work	7
Biodegradable Polymers and their Applications: A Review	7
Effects of Green Tea (−)-Epigallocatechin-3-Gallate (EGCG) on Cardiac Function - A Review of the Therapeutic Mechanism and Potentials	7
Meet the Section Editor	7
Developments in the Antitumor Activity, Mechanisms of Action, Structural Modifications, and Structure-Activity Relationships of Steroidal Saponins	7
Mitochondrial Proteins as Metabolic Biomarkers and Sites for Therapeutic Intervention in Primary and Metastatic Cancers	7
Phage-choline Kinase Inhibitor Combination to Control Pseudomonas aeruginosa: A Promising Combo	7
1,3,5-Triazine: Recent Development in Synthesis of its Analogs and Biological Profile	7
Osthole: Synthesis, Structural Modifications, and Biological Properties	7
Exploration of Potent Multi-target-directed-ligands as Anti-alzheimer’s Disease Agents: A Moiety Based Review	7
Cytotoxic Activity of Tropane Alkaloides of Species of Erythroxylum	7
The Role of Epigenetic Mechanisms in Autoimmune, Neurodegenerative, Cardiovascular, and Imprinting Disorders	7
Promising Enzymes for Inhibitors Development Against COVID-19	7
Nuclear Medicine Application of Pentixafor/Pentixather Targeting CXCR4 for Imaging and Therapy in Related Disease	6
2-Substituted-mercapto-quinazolin-4(3H)-ones as DHFR Inhibitors	6
In silico Approaches for Exploring the Pharmacological Activities of Benzimidazole Derivatives: A Comprehensive Review	6
Tuberculosis, BCG Vaccination, and COVID-19: Are They Connected?	6
Advances in Pyrazole Based Scaffold as Cyclin-dependent Kinase 2 Inhibitors for the Treatment of Cancer	6
Tanshinone IIA Against Cerebral Ischemic Stroke and Ischemia- Reperfusion Injury: A Review of the Current Documents	6
Anti-Tubercular Activity of Pyrazinamide Conjugates: Synthesis and Structure-Activity Relationship Studies	6
Recent Development of DNA Gyrase Inhibitors: An Update	6
Recent Progress of Bioactivities, Mechanisms of Action, Total Synthesis, Structural Modifications and Structure-activity Relationships of Indole Derivatives: A Review	6
Cyclin-Dependent Kinase 4/6 Inhibitors Against Breast Cancer	6
Meet the Editorial Board Member	6
Nano-biotechnology and its Innovative Perspective in Diabetes Management	6
The Progress of Small Molecule Targeting BCR-ABL in the Treatment of Chronic Myeloid Leukemia	6
Recent Advances in PI3 Kinase Inhibitors: Anticancer Activities and Structure-Activity Relationships	6
Research Progress on the Natural Product Aloperine and Its Derivatives	6
Molecular Targets for Chalcones in Antileishmanial Drug Discovery	6
Recent Advances in the Therapeutic Prospective of Heterocyclic Derivatives as COX-2 Inhibitors (2019-Present)	6
MiRNAs: Emerging Agents for Therapeutic Effects of Polyphenols on Ovarian Cancer	6
Antidiabetic Properties of Dietary Chrysin: A Cellular Mechanism Review	6
Acknowledgements to Reviewers	6
Anti-aging Natural Compounds and their Role in the Regulation of Metabolic Pathways Leading to Longevity	6
Preface	6
The Recent Developments of ADCs with the Tubulysins as the Payloads	6
Effectiveness of Azithromycin as Add-on Therapy in COVID-19 Management	6
A Review and Meta-analysis on Trastuzumab Resistance in Patients with HER2+ Breast Cancer	6
SARS-CoV-2 Infections, Impaired Tissue, and Metabolic Health: Pathophysiology and Potential Therapeutics	6
Chitosan: Applications in Drug Delivery System	6
MicroRNAs in Various Body Fluids and their Importance in Forensic Medicine	5
Nature-Derived Hit, Lead, and Drug-Like Small Molecules: Current Status and Future Aspects Against Key Target Proteins of Coronaviruses	5
An In Silico Approach to Exploring the Antinociceptive Biological Activities of Linalool and its Metabolites	5
Pharmaceutical Studies on Piperazine-based Compounds Targeting Serotonin Receptors and Serotonin Reuptake Transporters	5
Anticancer Drug Discovery By Structure-Based Repositioning Approach	5
An Outline on Benzimidazole Containing Marketed Drugs with Proton Pump Inhibitor and H1 Receptor Antagonist Activities	5