OOIR: Observatory of International Research

Papers

(The TQCC of Current Drug Targets is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Colorectal Cancer Epidemiology: Recent Trends and Impact on Outcomes	120
Chitosan Nanoparticles as a Novel Drug Delivery System: A Review Article	43
Characteristic of Cyclodextrins: Their Role and Use in the Pharmaceutical Technology	38
Natural Products as Anticancer Agents	37
Fluoroquinolones: Blessings Or Curses	36
Small-molecule Antiviral Agents in Ongoing Clinical Trials for COVID-19	29
Artificial Intelligence, Big Data and Machine Learning Approaches in Precision Medicine & Drug Discovery	29
Targeting Enteric Neurons and Plexitis for the Management of Inflammatory Bowel Disease	29
Novel Strategies to Combat the Emerging Drug Resistance in Human Pathogenic Microbes	27
Strategies and Therapies for Wound Healing: A Review	26
Biopolymer-based Scaffolds for Tissue Engineering Applications	25
Osteoblast-n-Osteoclast: Making Headway to Osteoporosis Treatment	25
Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data	23
Mitochondrial Dysfunction in Huntington’s Disease: Pathogenesis and Therapeutic Opportunities	22
Targeting Host Cell Proteases to Prevent SARS-CoV-2 Invasion	22
Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review	21
Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology	20
A Comprehensive Review on Chrysin: Emphasis on Molecular Targets, Pharmacological Actions and Bio-pharmaceutical Aspects	20
Antimicrobial Terpenoids as a Potential Substitute in Overcoming Antimicrobial Resistance	20
Recent Progress in Stimuli-Responsive Intelligent Nano Scale Drug Delivery Systems: A Special Focus Towards pH-Sensitive Systems	20
Remdesivir (GS-5734) in COVID-19 Therapy: The Fourth Chance	19
Redox Interactions in Chemo/Radiation Therapy-induced Lung Toxicity; Mechanisms and Therapy Perspectives	19
TL1A: A New Potential Target in the Treatment of Inflammatory Bowel Disease	19
Combinational Approaches Targeting Neurodegeneration, Oxidative Stress, and Inflammation in the Treatment of Diabetic Retinopathy	18
Cell-penetrating Peptide-mediated Nanovaccine Delivery	18

Fibrinogen, Fibrin, and Fibrin Degradation Products in COVID-19	17
COVID-19 and Renal Diseases: An Update	17
Anti-VEGF Mediated Immunomodulatory Role of Phytochemicals: Scientific Exposition for Plausible HCC Treatment	17
An Overview of Computer-aided Drug Design Tools and Recent Applications in Designing of Anti-diabetic Agents	17
Gamma Secretase Inhibitor: Therapeutic Target via NOTCH Signaling in T Cell Acute Lymphoblastic Leukemia	17
The Fate of Nanoparticles In Vivo and the Strategy of Designing Stealth Nanoparticle for Drug Delivery	15
An Insight Into Mitochondrial Dysfunction and its Implications in Neurological Diseases	15
Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling	15
Microbial Synthesis of Gold Nanoparticles and their Application	14
Kratom Dependence and Treatment Options: A Comprehensive Review of the Literature	14
A Review on Recent Development of Novel Heterocycles as Acetylcholinesterase Inhibitor for the Treatment of Alzheimer’s Disease	14
A Review on Rheumatoid Arthritis Interventions and Current Developments	14
Review of the Biological Activity of Maslinic Acid	14
Lung Pneumonitis and Fibrosis in Cancer Therapy: A Review on Cellular and Molecular Mechanisms	14
GSK-3 Inhibitors as New Leads to Treat Type-II Diabetes	13
Exploring Spike Protein as Potential Target of Novel Coronavirus and to Inhibit the Viability Utilizing Natural Agents	13
PD1 and PD-L1 Inhibitors for the Treatment of Kidney Cancer: The Role of PD-L1 Assay	13
Lipid Metabolism and Mitochondria: Cross Talk in Cancer	13
Post-menopausal Osteoporosis and Probiotics	13
P2X7 Receptor as a Potential Target for Major Depressive Disorder	12
An Updated Review for the Diabetic Wound Healing Systems	12
Targeting mTOR Signaling in Type 2 Diabetes Mellitus and Diabetes Complications	12
The Gut Microbiota and Traditional Chinese Medicine: A New Clinical Frontier on Cancer	12
Robotic Surgery in Inflammatory Bowel Disease	12
CD47 Functionalization of Nanoparticles as a Poly(ethylene glycol) Alternative: A Novel Approach to Improve Drug Delivery	11
Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson’s Disease	11
Targeting Hepatic Stellate Cell Death to Reverse Hepatic Fibrosis	11
The Potential Therapeutic Role of the HMGB1-TLR Pathway in Epilepsy	11
Thrombosis in IBD in the Era of JAK Inhibition	11
Insights into the Mechanism of the Therapeutic Potential of Herbal Monoamine Oxidase Inhibitors in Neurological Diseases	11
Role of ATP-binding Cassette Transporters in Sorafenib Therapy for Hepatocellular Carcinoma: An Overview	11
Overview on Thioredoxin-Interacting Protein (TXNIP): A Potential Target for Diabetes Intervention	11
Antimycotic Drugs and their Mechanisms of Resistance to Candida Species	11
Cyclic Nucleotides Signaling and Phosphodiesterase Inhibition: Defying Alzheimer’s Disease	11
Status of Programmed Death Ligand 1 (PD-L1) by Immunohistochemistry and Scoring Algorithms	11
PD-L1 Testing for Urothelial Carcinoma: Interchangeability, Reliability and Future Perspectives	11
Alzheimer's Disease and β-secretase Inhibition: An Update with a Focus on Computer-aided Inhibitor Design	11
Fibrotic Strictures in Crohn’s Disease: Mechanisms and Predictive Factors	11
Molecular Modeling Targeting Transmembrane Serine Protease 2 (TMPRSS2) as an Alternative Drug Target Against Coronaviruses	11
Antibiotic Potentiation of Natural Products: A Promising Target to Fight Pathogenic Bacteria	11
Biodegradable Nanoparticles: A Recent Approach and Applications	10
Nanotechnology Based Approach for Hepatocellular Carcinoma Targeting	10
Antibiotic Adjuvants: A Promising Approach to Combat Multidrug Resistant Bacteria	10
Anti-inflammatory Potential of GSK-3 Inhibitors	10
Adenosine Dysfunction in Epilepsy and Associated Comorbidities	10
Recent Advances in the Discovery of GSK-3 Inhibitors from Synthetic Origin in the Treatment of Neurological Disorders	10
Management of Glioblastoma Multiforme by Phytochemicals: Applications of Nanoparticle-Based Targeted Drug Delivery System	10
Current Quest in Natural Bioactive Compounds for Alzheimer’s Disease: Multi-Targeted-Designed-Ligand Based Approach with Preclinical and Clinical Based Evidence	10
Implications of microRNAs in the Pathogenesis of Atherosclerosis and Prospects for Therapy	10
Immunotherapy and Radiation Therapy in Renal Cell Carcinoma	10

Interplay between DNA Methyltransferase 1 and microRNAs During Tumorigenesis	10
Therapeutic Potential, Synthesis, Patent Evaluation and SAR Studies of Thieno[3,2-d]pyrimidine Derivatives: Recent Updates	9
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing	9
Herbal Medicine in the Treatment of Epilepsy	9
Thioethers: An Overview	9
Recent Update on the Alzheimer's Disease Progression, Diagnosis and Treatment Approaches	9
Challenges with Wound Infection Models in Drug Development	9
3D Printing Technology in Pharmaceutical Dosage Forms: Advantages and Challenges	9
Microbubbles Contrast Agents: General Overview as Diagnostics and Therapeutic Agent	9
A Review on Anti-urease Potential of Coumarins	9
Anti-VEGF Therapy in Myopic CNV	9
Metformin: A Promising Antidiabetic Medication for Cancer Treatment	9
A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders	8
Endogenous Enzyme-responsive Nanoplatforms for Anti-tumor Therapy	8
Elabela Peptide: An Emerging Target in Therapeutics	8
A Comprehensive Review on Liver Targeting: Emphasis on Nanotechnology- based Molecular Targets and Receptors Mediated Approaches	8
Self-Assembled Micelles of Amphiphilic PEGylated Drugs for Cancer Treatment	8
Facts and Myths: Efficacies of Repurposing Chloroquine and Hydroxychloroquine for the Treatment of COVID-19	8
Central Effects of Ivermectin in Alleviation of Covid-19-induced Dysauto-nomia	8
Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities	8
Vaginitis: Review on Drug Resistance	8
Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause, Mechanisms Involved, and Strategies to Combat	8
GSK-3 Inhibitors: A New Class of Drugs for Alzheimer’s Disease Treatment	8
Tissue Factor and COVID-19: An Update	8
Faecal Microbiota Transplantation in Inflammatory Bowel Disease: Current Concepts and Future Challenges	8
Microtubules and Cell Division: Potential Pharmacological Targets in Cancer Therapy	8
The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy	8
Glycogen Synthase Kinase-3 (GSK-3) Inhibitors as a New Lead for Treating Breast and Ovarian Cancer	8
New Approaches for the Treatment of Chagas Disease	8
Role of GSK-3 in Cardiac Health: Focusing on Cardiac Remodeling and Heart Failure	8
Bidirectional Relations Between Anxiety, Depression, and Cancer: A Review	7
The Role of Bacterial Proteases in Microbe and Host-microbe Interactions	7
Nutritional Support and Probiotics as a Potential Treatment of IBD	7
Targeting AMPK Signaling in the Liver: Implications for Obesity and Type 2 Diabetes Mellitus	7
HPV-mediated Cervical Cancer: A Systematic Review on Immunological Basis, Molecular Biology, and Immune Evasion Mechanisms	7
Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches	7
Pivotal Role of the Interaction Between Herbal Medicines and Gut Microbiota on Disease Treatment	7
Research Progress of PARP Inhibitor Monotherapy and Combination Therapy for Endometrial Cancer	7
Promising Protective Effects of Chrysin in Cardiometabolic Diseases	7
The Emergence of Immune-checkpoint Inhibitors in Colorectal Cancer Therapy	7
The Role of Immune and Epithelial Stem Cells in Inflammatory Bowel Disease Therapy	7
Berberine Administration in Treatment of Colitis: A Review	7
Free Fatty Acid Receptors as New Potential Targets in Colorectal Cancer	7
Neoadjuvant Strategies Before Radical Prostatectomy for High Risk Prostate Cancer in the Era of New Hormonal Agents	7
Targeting Triglyceride Metabolism for Colorectal Cancer Prevention and Therapy	7
A Review on CRISPR-mediated Epigenome Editing: A Future Directive for Therapeutic Management of Cancer	7
CPP-Based Bioactive Drug Delivery to Penetrate the Blood-Brain Barrier: A Potential Therapy for Glioblastoma Multiforme	6
Nanosponges Encapsulated Phytochemicals for Targeting Cancer: A Review	6
Insight γ-Secretase: Structure, Function, and Role in Alzheimer’s Disease	6
Venom of Viperidae: A Perspective of its Antibacterial and Antitumor Potential	6
Recent Advances in Psoriasis Therapy: Trends and Future Prospects	6
Fibrinolysis in COVID-19: Impact on Clot Lysis and Modulation of Inflammation	6
Inhibition of Virulence Factors and Biofilm Formation ofAcinetobacter Baumanniiby Naturally-derived and Synthetic Drugs	6
Anti-Degenerative Effect of Melatonin on Intervertebral Disc: Protective Contribution against Inflammation, Oxidative Stress, Apoptosis, and Autophagy	6
PD1/PD-L1 Axis in Uro-oncology	6
Pharmacological Exploration of Triazole-based Therapeutics for Alzheimer’s Disease: An Overview	6
A Comprehensive Review on Preclinical Evidence-based Neuroprotective Potential of Bacopa monnieri against Parkinson's Disease	6
Exosomes in Inflammatory Bowel Disease: What Have We Learned So Far?	6
Exosomes: A Novel Therapeutic Paradigm for the Treatment of Depression	6
Lipidomics as Tools for Finding Biomarkers of Intestinal Pathology: From Irritable Bowel Syndrome to Colorectal Cancer	6
Progress on the Mechanism for Aspirin’s Anti-tumor Effects	6
Fibroblast Growth Factor: Promising Target for Schizophrenia	6
Long Non-coding RNA Therapeutics: Recent Advances and Challenges	6
Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead	6
Histone Deacetylase Inhibitors as Cognitive Enhancers and Modifiers of Mood and Behavior	6