OOIR: Observatory of International Research

Papers

(The TQCC of Current Drug Targets is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Cell Entry and Unusual Replication of SARS-CoV-2	50
The Marburg Virus Outbreak in West Africa	46
Unfurling the Potential of Antiviral Agents Aimed for RNA Virus Ailment	46
The Development of the Combination Drug Leukovir® Tablets for the Treatment of Multiple Sclerosis: A Comprehensive Review	43
Current Research Trends in Cytokine Storm: A Scientometric Study	38
Metformin: A Promising Antidiabetic Medication for Cancer Treatment	36
Possible Applications of Azurin, a Copper-Containing Protein, in Cancer Treatment: Prospects and Challenges	35
Polymeric Micelle-Based Nanogels as Emerging Drug Delivery Systems in Breast Cancer Treatment: Promises and Challenges	34
Meet the Regional Editor	33
Review on the Drug Intolerance and Vaccine Development for the Leishmaniasis	33
Xerostomia: Advances and Challenges in Drug Development	30
Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery	28
Envisioning Glucose Transporters (GLUTs and SGLTs) as Novel Intervention against Cancer: Drug Discovery Perspective and Targeting Approach	27
Exploring the Potential Molecular Mechanisms of Berberine against Gastric Cancer Liver Metastasis Based on Network Pharmacology and Bioinformatics	27
Targeted Delivery Strategies of Herbal-Based Nanogels: Advancements and Applications	27
Targeting Neurodegeneration: The Emerging Role of Hybrid Drugs	25
Betaine, a Potential Therapeutic Alternative for the Treatment of Depression	25
COVID-19 Induces Cytokine Storm and Dysfunctional Hemostasis	24
Bile Acid Application in Cell-Targeting for Molecular Receptors in Relation to Hearing: A Comprehensive Review	23
RMNet: An RNA m6A Cross-species Methylation Detection Method for Nanopore Sequencing	23
An Updated Insight into Phytomolecules and Novel Approaches used in the Management of Breast Cancer	22
Targets Involved in the Pharmacology of Bothrops Snakebite: Statu Quo and Future Perspectives	21
Investigating Alternative Treatments for Dyslipidemia Using Bioactive Compounds Derived from Kiwifruit (Actinidia chinensis): A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulati	21
An Explainable Deep Learning Model for Clathrin Protein Prediction Using a DCT-Enhanced Position-Specific Scoring Matrix	20
An Overview of Research Advances in Oncology Regarding the Transcription Factor ATF4	20

Diabetic Nephropathy: Pathogenesis to Cure	20
Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials	20
IL-17 Antagonists as a Promising Therapeutic Modality for Hidradenitis Suppurativa	19
Mitochondria-Targeted Nanoformulations: New Therapeutic Strategies and Opportunities for Cancer Immunotherapy	17
Exploring the Efficient Natural Products for the Therapy of Parkinson’s Disease via Drosophila Melanogaster (Fruit Fly) Models	17
Robust Association of Breast Cancer Co-morbidity Using Subtype-specific Expressed Genes	17
Innovations in Antimalarial Drug Discovery: New Targets and Leads	17
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing	16
Rho Kinase (ROCK) Inhibitors for the Treatment of Glaucoma	16
The Role of Leukocyte Immunoglobulin-Like Receptors Focusing on the Therapeutic Implications of the Subfamily B2	16
A Comprehensive Insight on Pharmaceutical Co-crystals for Improvement of Aqueous Solubility	16
ClpP Peptidase as a Plausible Target for the Discovery of Novel Antibiotics	15
Transcription Factors in Brain Regeneration: A Potential Novel Therapeutic Target	15
Molecular Docking and Dynamics Simulations of Natural Limonoids Interacting with the Nipah Virus Attachment Glycoprotein	15
Targeting Creatine and Creatine Kinase in Cancer: Exploring Potential Therapeutic Strategies	14
Transcending Molecules: Paving the Way from Lab to Life in Drug Transport Innovation	14
Prospection of Microfluidics for Local Drug Delivery	14
Multi-target Compounds against Trypanosomatid Parasites and Mycobacterium tuberculosis	14
Phytovesicular Nanoconstructs for Advanced Delivery of Medicinal Metabolites: An In-Depth Review	13
Effect of Rotenone on the Neurodegeneration among Different Models	13
Recent Advances in Biomedical Applications of Mannans and Xylans	13
Recent Advances in the Development of Alpha-Glucosidase and Alpha-Amylase Inhibitors in Type 2 Diabetes Management: Insights from In silico to In vitro Studies	13
Potential Targets in Constipation Research: A Review	13
Identification of Natural Inhibitors against the Mycobacterium tuberculosis Proteasome: Computational Study	12
Multi-targeted Mechanisms of Erianin against Pancreatic Ductal Adenocarcinoma: Integrative Network Pharmacology, Bioinformatics, and Experimental Validation	12
A Review on the Current Status of Homeopathy in the Clinical Manage-ment of Cancer	11
The Recent Advances in the Function and Mechanism of Caveolin-1 in Retinal Neovascularization	11
RAAS Overactivation and Mitochondrial Damage Signaling as Key Players in Lethal COVID-19	11
Novel Approaches to Diagnosing and Treating Non-alcoholic Fatty Liver Disease: Opportunities and Accomplishments	11
Signaling Dynamics in Osteogenesis: Unraveling Therapeutic Targets for Bone Generation	11
Evaluating the Biological Activities of Oleanolic Acid and Apigenin in a 2-in-1 Nanoparticulate System: A Proof-of-concept Study	10
Meet the Editorial Board Member	10
MiRNAs Overexpression and Their Role in Breast Cancer: Implications for Cancer Therapeutics	10
An Exploratory Review on the Hypoglycemic Action of Unani Anti-diabetic Drugs via Possible Modulation of Gut Microbiota	10
Microbial Proteases: Pioneering Tools for Modern Therapeutic Innovations	10
Bidirectional Communication of Estrogen in Gut-Brain Axis: Evidence from Preclinical and Clinical Studies	10
FGMA: A Functional Group-enhanced Deep Learning Method for Drug Toxicity Prediction	9
Emerging Threats and Challenges of Monkeypox Virus: Exploration and Sensitivity	9
Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead	9
Nanoformulations - Insights Towards Characterization Techniques	9
Diabetic Wound Healing: Factors, Mechanisms, and Treatment Strategies Using Herbal Components	9
Targeted Covalent Inhibition: A Prospective Way to Develop Novel HSP90 C-terminal Inhibitor	9
Co-Crystallization: A Novel Technique to Improvise the Pharmaceutical Characteristics of API’s	9
Advances in Understanding and Managing Alzheimer's Disease: From Pathophysiology to Innovative Therapeutic Strategies	9
Skin Microbial Composition and Genetic Mutation Analysis in Precision Medicine for Epidermolysis Bullosa	9
Effects of Kefir Consumption on Cardiometabolic Risk Factors: A Systematic Review and Meta-analysis of Randomized Controlled Trials	9
Statin Therapy and C-reactive Protein in Patients with Kidney Disease: A Systematic Review and Meta-analysis of Randomized Clinical Trials	9
Proteasome as a Drug Target in Trypanosomatid Diseases	9
Hawthorn (Crataegus Species): Phytochemical Insights and Cardiotonic Mechanisms in Cardiovascular Health- A Comprehensive Review	9
Blockade of the GDF15/GFRAL Axis: Translational Advances in Cachexia, Immune Suppression, and Beyond	9

Multitarget Compounds for Neglected Diseases: A Review	9
Proteases and Osteoporosis: A Comprehensive Review of Their Role in Bone Health	8
A Review of Amylin Peptide Receptor Activators for Obesity Pharmacotherapy	8
Vaccine for Targeted Therapy of Lung Cancer: Advances and Developments	8
Acknowledgements to Reviewers	8
Systematic Identification and Characterization of Causal Risk Genes Implicated in Colorectal Cancer by Integrating GWAS, eQTL, and mQTL Data	8
Investigating the Mechanism of Astragalus mongholicus-Mediated Treatment of Silicosis in Mice from the Perspective of Alternative Splicing	8
Advances in Cysteine Protease B Inhibitors for Leishmaniasis Treatment	8
Superoxide Dismutase Inhibitors against Malaria, Leishmaniasis, and Chagas Disease: Systematic Review	8
Sepsis-Associated Brain Dysfunction: Mechanisms, Clinical Insights, and Therapeutic Strategies	8
Possible Role of Wnt Signaling Pathway in Diabetic Retinopathy	8
Meet the Associate Editorial Board Member	8
Long Non-coding RNAs in Non-small Cell Lung Carcinoma: Regulatory Mechanisms, Diagnostic Potential, and Therapeutic Perspectives	8
Differential Drug Permeability across Biofilms	7
Sodium-glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy	7
CRISPR-Cas9 Gene Editing: Promising Therapeutics for HPV-driven Cervical Cancer	7
Precision Targeting of BET Proteins - Navigating Disease Pathways, Inhibitor Insights, and Shaping Therapeutic Frontiers: A Comprehensive Review	7
Surface Functionalized Lipid Nanoparticles in Promoting Therapeutic Outcomes: An Insight View of the Dynamic Drug Delivery System	7
An Insight into Diverse Activities and Targets of Flavonoids	6
Cellular Therapeutics for Chronic Wound Healing: Future for Regenerative Medicine	6
Beyond AlphaFold: Charting the Future of AI in Protein Structure Prediction	6
Meet the Editorial Board Member	6
Mechanistic Approach to Ferroptosis in Cancer and Neurological Diseases	6
A Comprehensive Review on Therapeutic Potential of a Natural Anthraquinone Derivative Emodin in Brain-related Disorders	6
Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation of Mucuna pruriens for Parkinson's Disease Treatment	6
Meet the Regional Editor	6
An Update On Proficiency of Voltage-gated Ion Channel Blockers in the Treatment of Inflammation-associated Diseases	6
Targeted Regulation of Intracellular Signal Transduction: A New Paradigm for Stimulation of Neurogenesis in Alzheimer's Disease	6
The Resurgence of H3N2 in India: Is it Life-threatening?	6
Beneficial Outcomes of Cancer Therapeutic Modalities Based on Targeting Apoptosis	6
Bidirectional Relations Between Anxiety, Depression, and Cancer: A Review	6
Roadmap to Pyruvate Kinase M2 Modulation - A Computational Chronicle	6
Meet the Editorial Board Member	6
Polypharmacology-Driven Discovery and Design of Highly Selective, Dual and Multitargeting Inhibitors of Mycobacterium tuberculosis - A Review	6
FAVAR-GAT: A Hybrid Temporal-structural Model for Drug-target Binding Affinity Prediction	6
Meet the Editorial Board Member	6
The Mechanistic Role of Different Mediators in the Pathophysiology of Nephropathy: A Review	6
An Update on the Emerging Role of Wnt/β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis	6
(E)-Labda dial-Loaded Nanoparticles for Triple Negative Breast Cancer	6
Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies	6