Current Drug Targets

Article	Citations
Colorectal Cancer Epidemiology: Recent Trends and Impact on Outcomes	90
N6-methyladenine RNA Modification (m6A): An Emerging Regulator of Metabolic Diseases	33
Chitosan Nanoparticles as a Novel Drug Delivery System: A Review Article	32
Medicinal Perspective of Indole Derivatives: Recent Developments and Structure-Activity Relationship Studies	30
Characteristic of Cyclodextrins: Their Role and Use in the Pharmaceutical Technology	29
Novel Strategies to Combat the Emerging Drug Resistance in Human Pathogenic Microbes	28
Small-molecule Antiviral Agents in Ongoing Clinical Trials for COVID-19	28
Artificial Intelligence, Big Data and Machine Learning Approaches in Precision Medicine & Drug Discovery	27
Fluoroquinolones: Blessings Or Curses	27
Natural Products as Anticancer Agents	27
Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review	26
Strategies and Therapies for Wound Healing: A Review	26
The Therapeutic Potential of Quercetin in Parkinson’s Disease: Insights into its Molecular and Cellular Regulation	25
Targeting Enteric Neurons and Plexitis for the Management of Inflammatory Bowel Disease	24
Anti-VEGF Treatment in Corneal Diseases	24
Targeting Host Cell Proteases to Prevent SARS-CoV-2 Invasion	23
Biopolymer-based Scaffolds for Tissue Engineering Applications	22
Molecular Mechanism of Resistance to Chemotherapy in Gastric Cancers, the Role of Autophagy	21
Understanding the Pharmaceutical Aspects of Dendrimers for the Delivery of Anticancer Drugs	20
Alzheimer’s Disease Targeted Nano-Based Drug Delivery Systems	20
Edaravone May Prevent Ferroptosis in ALS	20
Osteoblast-n-Osteoclast: Making Headway to Osteoporosis Treatment	20
Navigating Alzheimer’s Disease via Chronic Stress: The Role of Glucocorticoids	20
Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology	19
IL-37 As a Potential Biotherapeutics of Inflammatory Diseases	19

Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data	19
Antimicrobial Terpenoids as a Potential Substitute in Overcoming Antimicrobial Resistance	18
Remdesivir (GS-5734) in COVID-19 Therapy: The Fourth Chance	17
Recent Progress in Stimuli-Responsive Intelligent Nano Scale Drug Delivery Systems: A Special Focus Towards pH-Sensitive Systems	16
Mitochondrial Dysfunction in Huntington’s Disease: Pathogenesis and Therapeutic Opportunities	16
Combinational Approaches Targeting Neurodegeneration, Oxidative Stress, and Inflammation in the Treatment of Diabetic Retinopathy	16
Plant Polyphenols as Neuroprotective Agents in Parkinson’s Disease Targeting Oxidative Stress	15
The Potential of PI3K/AKT/mTOR Signaling as a Druggable Target for Endometrial and Ovarian Carcinomas	15
Post-menopausal Osteoporosis and Probiotics	15
COVID-19 and Renal Diseases: An Update	15
Cell-penetrating Peptide-mediated Nanovaccine Delivery	15
The Epigenetic Modification of Epigallocatechin Gallate (EGCG) on Cancer	15
Inflammation as a Therapeutic Target for Various Deadly Disorders: A Review	15
Anti-VEGF Mediated Immunomodulatory Role of Phytochemicals: Scientific Exposition for Plausible HCC Treatment	15
CD28: A New Drug Target for Immune Disease	14
Challenges and New Therapeutic Approaches in the Management of Chronic Wounds	14
Novel Treatment for the Most Resistant Schizophrenia: Dual Activation of NMDA Receptor and Antioxidant	14
Kratom Dependence and Treatment Options: A Comprehensive Review of the Literature	14
Redox Interactions in Chemo/Radiation Therapy-induced Lung Toxicity; Mechanisms and Therapy Perspectives	14
The Fate of Nanoparticles In Vivo and the Strategy of Designing Stealth Nanoparticle for Drug Delivery	14
Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities	13
A Comprehensive Review on Chrysin: Emphasis on Molecular Targets, Pharmacological Actions and Bio-pharmaceutical Aspects	13
New Anti-VEGF Drugs in Ophthalmology	13
Exploring Spike Protein as Potential Target of Novel Coronavirus and to Inhibit the Viability Utilizing Natural Agents	13
Lipid Metabolism and Mitochondria: Cross Talk in Cancer	12
A Review of Aberrant DNA Methylation and Epigenetic Agents Targeting DNA Methyltransferases in Endometriosis	12
Molecular and Biological Functions of Melatonin in Endometrial Cancer	12
An Insight Into Mitochondrial Dysfunction and its Implications in Neurological Diseases	12
PD1 and PD-L1 Inhibitors for the Treatment of Kidney Cancer: The Role of PD-L1 Assay	12
Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling	12
ACE2/Angiotensin-(1-7)/Mas Receptor Axis in Human Cancer: Potential Role for Pediatric Tumors	12
Gamma Secretase Inhibitor: Therapeutic Target via NOTCH Signaling in T Cell Acute Lymphoblastic Leukemia	12
Current Quest in Natural Bioactive Compounds for Alzheimer’s Disease: Multi-Targeted-Designed-Ligand Based Approach with Preclinical and Clinical Based Evidence	11
Cyclic Nucleotides Signaling and Phosphodiesterase Inhibition: Defying Alzheimer’s Disease	11
Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson’s Disease	11
PD-L1 Testing for Urothelial Carcinoma: Interchangeability, Reliability and Future Perspectives	11
MicroRNAs in Noise-Induced Hearing Loss and their Regulation by Oxidative Stress and Inflammation	11
The Role of Reactive Oxygen Species in Tumor Treatment and its Impact on Bone Marrow Hematopoiesis	11
Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy	11
Alzheimer's Disease and β-secretase Inhibition: An Update with a Focus on Computer-aided Inhibitor Design	11
Targeting Strategies in Therapeutic Applications of Toxoplasmosis: Recent Advances in Liposomal Vaccine Delivery Systems	11
TL1A: A New Potential Target in the Treatment of Inflammatory Bowel Disease	11
The Gut Microbiota and Traditional Chinese Medicine: A New Clinical Frontier on Cancer	11
Thrombosis in IBD in the Era of JAK Inhibition	10
Robotic Surgery in Inflammatory Bowel Disease	10
Lung Pneumonitis and Fibrosis in Cancer Therapy: A Review on Cellular and Molecular Mechanisms	10
GSK-3 Inhibitors as New Leads to Treat Type-II Diabetes	10
An Overview of Computer-aided Drug Design Tools and Recent Applications in Designing of Anti-diabetic Agents	10
Microbial Synthesis of Gold Nanoparticles and their Application	10
Natural Aldose Reductase Inhibitor: A Potential Therapeutic Agent for Non-alcoholic Fatty Liver Disease	10

Review of the Biological Activity of Maslinic Acid	10
A Molecular Cascade Underlying Articular Cartilage Degeneration	10
Immunotherapy and Radiation Therapy in Renal Cell Carcinoma	10
Anti-inflammatory Potential of GSK-3 Inhibitors	10
Plasminogen Receptors in Human Malignancies: Effects on Prognosis and Feasibility as Targets for Drug Development	9
P2X7 Receptor as a Potential Target for Major Depressive Disorder	9
Status of Programmed Death Ligand 1 (PD-L1) by Immunohistochemistry and Scoring Algorithms	9
A Review on Rheumatoid Arthritis Interventions and Current Developments	9
An Insight into the Current Perspective and Potential Drug Targets for Visceral Leishmaniasis (VL)	9
Antibiotic Potentiation of Natural Products: A Promising Target to Fight Pathogenic Bacteria	9
Implications of microRNAs in the Pathogenesis of Atherosclerosis and Prospects for Therapy	9
Combining Growth Factor and Stem Cell Therapy for Stroke Rehabilitation, A Review	9
The Potential Therapeutic Role of the HMGB1-TLR Pathway in Epilepsy	9
Recent Advances in the Discovery of GSK-3 Inhibitors from Synthetic Origin in the Treatment of Neurological Disorders	9
Application of Artificial Intelligence in Targeting Retinal Diseases	9
CD47 Functionalization of Nanoparticles as a Poly(ethylene glycol) Alternative: A Novel Approach to Improve Drug Delivery	9
Nanotechnology Based Approach for Hepatocellular Carcinoma Targeting	9
Management of Glioblastoma Multiforme by Phytochemicals: Applications of Nanoparticle-Based Targeted Drug Delivery System	9
Molecular Modeling Targeting Transmembrane Serine Protease 2 (TMPRSS2) as an Alternative Drug Target Against Coronaviruses	8
A Review on Anti-urease Potential of Coumarins	8
Targeting mTOR Signaling in Type 2 Diabetes Mellitus and Diabetes Complications	8
Antibiotic Adjuvants: A Promising Approach to Combat Multidrug Resistant Bacteria	8
Faecal Microbiota Transplantation in Inflammatory Bowel Disease: Current Concepts and Future Challenges	8
Inhibition of Virulence Factors and Biofilm Formation ofAcinetobacter Baumanniiby Naturally-derived and Synthetic Drugs	8
Prediction of Late Recurrence and Distant Metastasis in Early-stage Breast Cancer: Overview of Current and Emerging Biomarkers	8
Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause, Mechanisms Involved, and Strategies to Combat	8
Interplay between DNA Methyltransferase 1 and microRNAs During Tumorigenesis	8
Thioethers: An Overview	8
Cardiovascular Modulating Effects of Magnolol and Honokiol, Two Polyphenolic Compounds from Traditional Chinese Medicine-Magnolia Officinalis	8
Antimycotic Drugs and their Mechanisms of Resistance to Candida Species	8
Challenges with Wound Infection Models in Drug Development	8
Role of GSK-3 in Cardiac Health: Focusing on Cardiac Remodeling and Heart Failure	8
Role of ATP-binding Cassette Transporters in Sorafenib Therapy for Hepatocellular Carcinoma: An Overview	8
Fibrinogen, Fibrin, and Fibrin Degradation Products in COVID-19	7
Anti-VEGF Therapy in Myopic CNV	7
Promising Protective Effects of Chrysin in Cardiometabolic Diseases	7
An Updated Review for the Diabetic Wound Healing Systems	7
Facts and Myths: Efficacies of Repurposing Chloroquine and Hydroxychloroquine for the Treatment of COVID-19	7
Current and Future Prospective of a Versatile Moiety: Imidazole	7
Overview on Thioredoxin-Interacting Protein (TXNIP): A Potential Target for Diabetes Intervention	7
Biodegradable Nanoparticles: A Recent Approach and Applications	7
Targeted Drug Delivery Using Tuftsin-bearing Liposomes: Implications in the Treatment of Infectious Diseases and Tumors	7
Adenosine Dysfunction in Epilepsy and Associated Comorbidities	7
Free Fatty Acid Receptors as New Potential Targets in Colorectal Cancer	7
Self-Assembled Micelles of Amphiphilic PEGylated Drugs for Cancer Treatment	7
Herbal Medicine in the Treatment of Epilepsy	7
Tissue Factor and COVID-19: An Update	7
BRCA Mutational Status is a Promising Predictive Biomarker for Platinum- based Chemotherapy in Triple-Negative Breast Cancer	7
Central Effects of Ivermectin in Alleviation of Covid-19-induced Dysauto-nomia	7
Nanotechnology-based Targeting of Neurodegenerative Disorders: A Promising Tool for Efficient Delivery of Neuromedicines	7
Antiplatelet Effects of Bioactive Compounds Present in Tomato Pomace	7
Application of Ultrasound Elastography for Assessing Intestinal Fibrosis in Inflammatory Bowel Disease: Fiction or Reality?	7
Vaginitis: Review on Drug Resistance	7
A Review on CRISPR-mediated Epigenome Editing: A Future Directive for Therapeutic Management of Cancer	7
3D Printing Technology in Pharmaceutical Dosage Forms: Advantages and Challenges	7
The Role of Immune and Epithelial Stem Cells in Inflammatory Bowel Disease Therapy	7
Therapeutic Potential, Synthesis, Patent Evaluation and SAR Studies of Thieno[3,2-d]pyrimidine Derivatives: Recent Updates	7
The Association and Influencing Factors between Antipsychotics Exposure and the Risk of VTE and PE: A Systematic Review and Meta-analysis	7
The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy	7
Targeting Hepatic Stellate Cell Death to Reverse Hepatic Fibrosis	6
Endogenous Enzyme-responsive Nanoplatforms for Anti-tumor Therapy	6
Pivotal Role of the Interaction Between Herbal Medicines and Gut Microbiota on Disease Treatment	6
PD1/PD-L1 Axis in Uro-oncology	6
Nanosponges Encapsulated Phytochemicals for Targeting Cancer: A Review	6
Unveiling the Targets Involved in the Quest of Antileishmanial Leads Using In silico Methods	6
Exosomes in Inflammatory Bowel Disease: What Have We Learned So Far?	6
Metformin: A Promising Antidiabetic Medication for Cancer Treatment	6
Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches	6
Elabela Peptide: An Emerging Target in Therapeutics	6
Exosomes: A Novel Therapeutic Paradigm for the Treatment of Depression	6
Anti-VEGF and Retinal Dystrophies	6
Neoadjuvant Strategies Before Radical Prostatectomy for High Risk Prostate Cancer in the Era of New Hormonal Agents	6
Pharmacological Exploration of Triazole-based Therapeutics for Alzheimer’s Disease: An Overview	6
The Emergence of Immune-checkpoint Inhibitors in Colorectal Cancer Therapy	6
Recent Advances in Psoriasis Therapy: Trends and Future Prospects	6
MiRNA, a New Treatment Strategy for Pulmonary Fibrosis	6
Recent Update on the Alzheimer's Disease Progression, Diagnosis and Treatment Approaches	6
Berberine Administration in Treatment of Colitis: A Review	6
Fibrotic Strictures in Crohn’s Disease: Mechanisms and Predictive Factors	6
Research Progress of PARP Inhibitor Monotherapy and Combination Therapy for Endometrial Cancer	6

Targeting Triglyceride Metabolism for Colorectal Cancer Prevention and Therapy	6
Insights into the Mechanism of the Therapeutic Potential of Herbal Monoamine Oxidase Inhibitors in Neurological Diseases	6
Venom of Viperidae: A Perspective of its Antibacterial and Antitumor Potential	6
Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead	6