Current Drug Targets

Article	Citations
Colorectal Cancer Epidemiology: Recent Trends and Impact on Outcomes	83
N6-methyladenine RNA Modification (m6A): An Emerging Regulator of Metabolic Diseases	32
Chitosan Nanoparticles as a Novel Drug Delivery System: A Review Article	30
Medicinal Perspective of Indole Derivatives: Recent Developments and Structure-Activity Relationship Studies	29
Novel Strategies to Combat the Emerging Drug Resistance in Human Pathogenic Microbes	28
Small-molecule Antiviral Agents in Ongoing Clinical Trials for COVID-19	28
Characteristic of Cyclodextrins: Their Role and Use in the Pharmaceutical Technology	27
Natural Products as Anticancer Agents	27
Artificial Intelligence, Big Data and Machine Learning Approaches in Precision Medicine & Drug Discovery	27
Strategies and Therapies for Wound Healing: A Review	26
The Therapeutic Potential of Quercetin in Parkinson’s Disease: Insights into its Molecular and Cellular Regulation	25
Fluoroquinolones: Blessings Or Curses	24
Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review	24
Targeting Host Cell Proteases to Prevent SARS-CoV-2 Invasion	23
Targeting Enteric Neurons and Plexitis for the Management of Inflammatory Bowel Disease	23
Anti-VEGF Treatment in Corneal Diseases	22
Biopolymer-based Scaffolds for Tissue Engineering Applications	22
Osteoblast-n-Osteoclast: Making Headway to Osteoporosis Treatment	20
Navigating Alzheimer’s Disease via Chronic Stress: The Role of Glucocorticoids	20
Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data	19
Understanding the Pharmaceutical Aspects of Dendrimers for the Delivery of Anticancer Drugs	19
IL-37 As a Potential Biotherapeutics of Inflammatory Diseases	19
Molecular Mechanism of Resistance to Chemotherapy in Gastric Cancers, the Role of Autophagy	19
Edaravone May Prevent Ferroptosis in ALS	19
Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology	19

Candida auris and Nosocomial Infection	19
Alzheimer’s Disease Targeted Nano-Based Drug Delivery Systems	18
Neutrophilic Asthma and Potentially Related Target Therapies	18
Antimicrobial Terpenoids as a Potential Substitute in Overcoming Antimicrobial Resistance	17
Remdesivir (GS-5734) in COVID-19 Therapy: The Fourth Chance	17
Recent Progress in Stimuli-Responsive Intelligent Nano Scale Drug Delivery Systems: A Special Focus Towards pH-Sensitive Systems	16
Mitochondrial Dysfunction in Huntington’s Disease: Pathogenesis and Therapeutic Opportunities	16
Combinational Approaches Targeting Neurodegeneration, Oxidative Stress, and Inflammation in the Treatment of Diabetic Retinopathy	15
COVID-19 and Renal Diseases: An Update	15
Anti-VEGF Mediated Immunomodulatory Role of Phytochemicals: Scientific Exposition for Plausible HCC Treatment	15
The Potential of PI3K/AKT/mTOR Signaling as a Druggable Target for Endometrial and Ovarian Carcinomas	15
Post-menopausal Osteoporosis and Probiotics	15
Plant Polyphenols as Neuroprotective Agents in Parkinson’s Disease Targeting Oxidative Stress	15
CD28: A New Drug Target for Immune Disease	14
Inflammation as a Therapeutic Target for Various Deadly Disorders: A Review	14
The Epigenetic Modification of Epigallocatechin Gallate (EGCG) on Cancer	14
Novel Treatment for the Most Resistant Schizophrenia: Dual Activation of NMDA Receptor and Antioxidant	14
Challenges and New Therapeutic Approaches in the Management of Chronic Wounds	14
The Fate of Nanoparticles In Vivo and the Strategy of Designing Stealth Nanoparticle for Drug Delivery	14
Cell-penetrating Peptide-mediated Nanovaccine Delivery	14
Kratom Dependence and Treatment Options: A Comprehensive Review of the Literature	14
Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities	13
Redox Interactions in Chemo/Radiation Therapy-induced Lung Toxicity; Mechanisms and Therapy Perspectives	13
New Anti-VEGF Drugs in Ophthalmology	13
A Comprehensive Review on Chrysin: Emphasis on Molecular Targets, Pharmacological Actions and Bio-pharmaceutical Aspects	13
PD1 and PD-L1 Inhibitors for the Treatment of Kidney Cancer: The Role of PD-L1 Assay	12
Exploring Spike Protein as Potential Target of Novel Coronavirus and to Inhibit the Viability Utilizing Natural Agents	12
Lipid Metabolism and Mitochondria: Cross Talk in Cancer	12
Gamma Secretase Inhibitor: Therapeutic Target via NOTCH Signaling in T Cell Acute Lymphoblastic Leukemia	12
Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling	12
A Review of Aberrant DNA Methylation and Epigenetic Agents Targeting DNA Methyltransferases in Endometriosis	12
Molecular and Biological Functions of Melatonin in Endometrial Cancer	12
ACE2/Angiotensin-(1-7)/Mas Receptor Axis in Human Cancer: Potential Role for Pediatric Tumors	11
The Role of Reactive Oxygen Species in Tumor Treatment and its Impact on Bone Marrow Hematopoiesis	11
The Gut Microbiota and Traditional Chinese Medicine: A New Clinical Frontier on Cancer	11
Alzheimer's Disease and β-secretase Inhibition: An Update with a Focus on Computer-aided Inhibitor Design	11
Current Quest in Natural Bioactive Compounds for Alzheimer’s Disease: Multi-Targeted-Designed-Ligand Based Approach with Preclinical and Clinical Based Evidence	11
Targeting Strategies in Therapeutic Applications of Toxoplasmosis: Recent Advances in Liposomal Vaccine Delivery Systems	11
Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy	11
PD-L1 Testing for Urothelial Carcinoma: Interchangeability, Reliability and Future Perspectives	11
An Insight Into Mitochondrial Dysfunction and its Implications in Neurological Diseases	11
Cyclic Nucleotides Signaling and Phosphodiesterase Inhibition: Defying Alzheimer’s Disease	11
Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson’s Disease	11
Current Study of the Detection and Treatment Targets of Spinal Tuberculosis	11
Review of the Biological Activity of Maslinic Acid	10
A Molecular Cascade Underlying Articular Cartilage Degeneration	10
Immunotherapy and Radiation Therapy in Renal Cell Carcinoma	10
Thrombosis in IBD in the Era of JAK Inhibition	10
Robotic Surgery in Inflammatory Bowel Disease	10
Natural Aldose Reductase Inhibitor: A Potential Therapeutic Agent for Non-alcoholic Fatty Liver Disease	10

GSK-3 Inhibitors as New Leads to Treat Type-II Diabetes	10
An Overview of Computer-aided Drug Design Tools and Recent Applications in Designing of Anti-diabetic Agents	10
Microbial Synthesis of Gold Nanoparticles and their Application	10
Anti-inflammatory Potential of GSK-3 Inhibitors	10
The Potential Therapeutic Role of the HMGB1-TLR Pathway in Epilepsy	9
Nanotechnology Based Approach for Hepatocellular Carcinoma Targeting	9
An Insight into the Current Perspective and Potential Drug Targets for Visceral Leishmaniasis (VL)	9
Implications of microRNAs in the Pathogenesis of Atherosclerosis and Prospects for Therapy	9
P2X7 Receptor as a Potential Target for Major Depressive Disorder	9
Plasminogen Receptors in Human Malignancies: Effects on Prognosis and Feasibility as Targets for Drug Development	9
Recent Advances in the Discovery of GSK-3 Inhibitors from Synthetic Origin in the Treatment of Neurological Disorders	9
TL1A: A New Potential Target in the Treatment of Inflammatory Bowel Disease	9
Status of Programmed Death Ligand 1 (PD-L1) by Immunohistochemistry and Scoring Algorithms	9
Application of Artificial Intelligence in Targeting Retinal Diseases	9
CD47 Functionalization of Nanoparticles as a Poly(ethylene glycol) Alternative: A Novel Approach to Improve Drug Delivery	9
Lung Pneumonitis and Fibrosis in Cancer Therapy: A Review on Cellular and Molecular Mechanisms	9
MicroRNAs in Noise-Induced Hearing Loss and their Regulation by Oxidative Stress and Inflammation	9
Antibiotic Potentiation of Natural Products: A Promising Target to Fight Pathogenic Bacteria	9
Cardiovascular Modulating Effects of Magnolol and Honokiol, Two Polyphenolic Compounds from Traditional Chinese Medicine-Magnolia Officinalis	8
Antimycotic Drugs and their Mechanisms of Resistance to Candida Species	8
Combining Growth Factor and Stem Cell Therapy for Stroke Rehabilitation, A Review	8
Interplay between DNA Methyltransferase 1 and microRNAs During Tumorigenesis	8
Thioethers: An Overview	8
Molecular Modeling Targeting Transmembrane Serine Protease 2 (TMPRSS2) as an Alternative Drug Target Against Coronaviruses	8
A Review on Anti-urease Potential of Coumarins	8
A Review on Rheumatoid Arthritis Interventions and Current Developments	8
Management of Glioblastoma Multiforme by Phytochemicals: Applications of Nanoparticle-Based Targeted Drug Delivery System	8
Inhibition of Virulence Factors and Biofilm Formation ofAcinetobacter Baumanniiby Naturally-derived and Synthetic Drugs	8
Challenges with Wound Infection Models in Drug Development	8
Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause, Mechanisms Involved, and Strategies to Combat	8
Faecal Microbiota Transplantation in Inflammatory Bowel Disease: Current Concepts and Future Challenges	8
The Role of Immune and Epithelial Stem Cells in Inflammatory Bowel Disease Therapy	7
Therapeutic Potential, Synthesis, Patent Evaluation and SAR Studies of Thieno[3,2-d]pyrimidine Derivatives: Recent Updates	7
Nanotechnology-based Targeting of Neurodegenerative Disorders: A Promising Tool for Efficient Delivery of Neuromedicines	7
Study of Intercellular Adhesion Molecule-1 (ICAM-1) in Bone Homeostasis	7
Anti-VEGF Therapy in Myopic CNV	7
Prediction of Late Recurrence and Distant Metastasis in Early-stage Breast Cancer: Overview of Current and Emerging Biomarkers	7
Targeting mTOR Signaling in Type 2 Diabetes Mellitus and Diabetes Complications	7
Antibiotic Adjuvants: A Promising Approach to Combat Multidrug Resistant Bacteria	7
Current and Future Prospective of a Versatile Moiety: Imidazole	7
Central Effects of Ivermectin in Alleviation of Covid-19-induced Dysauto-nomia	7
Overview on Thioredoxin-Interacting Protein (TXNIP): A Potential Target for Diabetes Intervention	7
Targeted Drug Delivery Using Tuftsin-bearing Liposomes: Implications in the Treatment of Infectious Diseases and Tumors	7
Adenosine Dysfunction in Epilepsy and Associated Comorbidities	7
Free Fatty Acid Receptors as New Potential Targets in Colorectal Cancer	7
Promising Protective Effects of Chrysin in Cardiometabolic Diseases	7
Facts and Myths: Efficacies of Repurposing Chloroquine and Hydroxychloroquine for the Treatment of COVID-19	7
Herbal Medicine in the Treatment of Epilepsy	7
BRCA Mutational Status is a Promising Predictive Biomarker for Platinum- based Chemotherapy in Triple-Negative Breast Cancer	7
The Association and Influencing Factors between Antipsychotics Exposure and the Risk of VTE and PE: A Systematic Review and Meta-analysis	7
The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy	7
Antiplatelet Effects of Bioactive Compounds Present in Tomato Pomace	7
Vaginitis: Review on Drug Resistance	7
Application of Ultrasound Elastography for Assessing Intestinal Fibrosis in Inflammatory Bowel Disease: Fiction or Reality?	7
Self-Assembled Micelles of Amphiphilic PEGylated Drugs for Cancer Treatment	7
A Review on CRISPR-mediated Epigenome Editing: A Future Directive for Therapeutic Management of Cancer	7
The Emergence of Immune-checkpoint Inhibitors in Colorectal Cancer Therapy	6
Exosomes in Inflammatory Bowel Disease: What Have We Learned So Far?	6
Metformin: A Promising Antidiabetic Medication for Cancer Treatment	6
Role of ATP-binding Cassette Transporters in Sorafenib Therapy for Hepatocellular Carcinoma: An Overview	6
Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches	6
Elabela Peptide: An Emerging Target in Therapeutics	6
Endogenous Enzyme-responsive Nanoplatforms for Anti-tumor Therapy	6
Fibrinogen, Fibrin, and Fibrin Degradation Products in COVID-19	6
Targeting Triglyceride Metabolism for Colorectal Cancer Prevention and Therapy	6
Nanosponges Encapsulated Phytochemicals for Targeting Cancer: A Review	6
Unveiling the Targets Involved in the Quest of Antileishmanial Leads Using In silico Methods	6
An Updated Review for the Diabetic Wound Healing Systems	6
Tissue Factor and COVID-19: An Update	6
Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead	6
Targeting Hepatic Stellate Cell Death to Reverse Hepatic Fibrosis	6
Biodegradable Nanoparticles: A Recent Approach and Applications	6
Fibrotic Strictures in Crohn’s Disease: Mechanisms and Predictive Factors	6
Anti-VEGF and Retinal Dystrophies	6
Pharmacological Exploration of Triazole-based Therapeutics for Alzheimer’s Disease: An Overview	6
Combining Radiotherapy with Immunocheckpoint Inhibitors or CAR-T in Renal Cell Carcinoma	6
3D Printing Technology in Pharmaceutical Dosage Forms: Advantages and Challenges	6
Venom of Viperidae: A Perspective of its Antibacterial and Antitumor Potential	6
Recent Advances in Psoriasis Therapy: Trends and Future Prospects	6
MiRNA, a New Treatment Strategy for Pulmonary Fibrosis	6

Exosomes: A Novel Therapeutic Paradigm for the Treatment of Depression	6
Berberine Administration in Treatment of Colitis: A Review	6
Pivotal Role of the Interaction Between Herbal Medicines and Gut Microbiota on Disease Treatment	6
Insights into the Mechanism of the Therapeutic Potential of Herbal Monoamine Oxidase Inhibitors in Neurological Diseases	6
PD1/PD-L1 Axis in Uro-oncology	6
Role of GSK-3 in Cardiac Health: Focusing on Cardiac Remodeling and Heart Failure	6
Neoadjuvant Strategies Before Radical Prostatectomy for High Risk Prostate Cancer in the Era of New Hormonal Agents	5
A Review on Emerging Drug Targets in Treatment of Schizophrenia	5
Molecular Signaling Pathways and Essential Metabolic Elements in Bone Remodeling: An Implication of Therapeutic Targets for Bone Diseases	5
Recent Progress on Apoptotic Activity of Triazoles	5
A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders	5
The Activating Receptors of Natural Killer Cells and Their Inter-Switching Potentials	5
Research Progress of PARP Inhibitor Monotherapy and Combination Therapy for Endometrial Cancer	5
GSK-3 Inhibitors: A New Class of Drugs for Alzheimer’s Disease Treatment	5
How can we Preserve Sexual Function after Ablative Surgery for Benign Prostatic Hyperplasia?	5
Epigenetic Modifications as Therapeutic Targets	5
The Ubiquitin-Proteasome Pathway and Resistance Mechanisms Developed Against the Proteasomal Inhibitors in Cancer Cells	5
Elucidation of Abnormal Extracellular Regulated Kinase (ERK) Signaling and Associations with Syndromic and Non-syndromic Autism	5
Nutritional Support and Probiotics as a Potential Treatment of IBD	5
Progress on the Mechanism for Aspirin’s Anti-tumor Effects	5
Is HE4 Superior over CA-125 in the Follow-up of Patients with Epithelial Ovarian Cancer?	5
Amendatory Effect of Flavonoids in Alzheimer's Disease Against Mitochondrial Dysfunction	5
Microbubbles Contrast Agents: General Overview as Diagnostics and Therapeutic Agent	5
CPP-Based Bioactive Drug Delivery to Penetrate the Blood-Brain Barrier: A Potential Therapy for Glioblastoma Multiforme	5
Recent Update on the Alzheimer's Disease Progression, Diagnosis and Treatment Approaches	5
A Comprehensive Review on Liver Targeting: Emphasis on Nanotechnology- based Molecular Targets and Receptors Mediated Approaches	4
Insight γ-Secretase: Structure, Function, and Role in Alzheimer’s Disease	4
Is Galanin a Promising Therapeutic Resource for Neural and Nonneural Diseases?	4
Recent Advances in Nanotechnology-Based Drug Delivery Approaches for Alzheimer disease	4
Ferula hermonis: A Review of Current Use and Pharmacological Studies of its Sesquiterpene Ester Ferutinin	4
Fibroblast Growth Factors as Tools in the Management of Neuropathic Pain Disorders	4
Microsatellite Instability as a Predictor of Outcomes in Colorectal Cancer in the Era of Immune-Checkpoint Inhibitors	4
Histone Deacetylase Inhibitors as Cognitive Enhancers and Modifiers of Mood and Behavior	4
miRNAs as Modulators of Cholesterol in Breast Cancer Stem Cells: An Approach to Overcome Drug Resistance in Cancer	4
Use of Anti-VEGF Drugs in Retinal Vein Occlusions	4
Preclinical Drug Discovery in Colorectal Cancer: A Focus on Natural Compounds	4
New Approaches for the Treatment of Chagas Disease	4
Fibroblast Growth Factor: Promising Target for Schizophrenia	4
Drugs or Mechanical Devices for Obstructive LUTS?	4
The Study of Natural Compounds Targeting RANKL Signaling Pathway for the Treatment of Bone Diseases	4
Targeted Mitochondrial Drugs for Treatment of Ischemia-Reperfusion Injury	4
A Glance on the Role of Bacterial Siderophore from the Perspectives of Medical and Biotechnological Approaches	4
Rediscovering Tocophersolan: A Renaissance for Nano-Based Drug Delivery and Nanotheranostic Applications	4
PD-L1 Inhibitors for the Treatment of Prostate Cancer	4
The Role of Bacterial Proteases in Microbe and Host-microbe Interactions	4
Curcumin Sensitizes Cancers Towards TRAIL-induced Apoptosis via Extrinsic and Intrinsic Apoptotic Pathways	4
Lipidomics as Tools for Finding Biomarkers of Intestinal Pathology: From Irritable Bowel Syndrome to Colorectal Cancer	4
An Overview of Prospective Drugs for Type 1 and Type 2 Diabetes	4
Biomimetic Drug Delivery Systems Oriented by Biological Function in Tumor Targeting	4
Present Scenario of M-Cell Targeting Ligands for Oral Mucosal Immunization	4
Does Pharmacodynamics of Drugs Change After Presenting them as Nanoparticles Like their Pharmacokinetics?	4
A Review on Recent Development of Novel Heterocycles as Acetylcholinesterase Inhibitor for the Treatment of Alzheimer’s Disease	4
Role of γ-Secretase Inhibitors for the Treatment of Diverse Disease Conditions through Inhibition of Notch Signaling Pathway	4
Natural Occurring Compounds Inhibit Osteoclastogenesis via Targeting NFATc1-related Signaling Pathways	4
The Regulatory Role of Rho GTPases and their Substrates in Osteoclastogenesis	4
Anti-Degenerative Effect of Melatonin on Intervertebral Disc: Protective Contribution against Inflammation, Oxidative Stress, Apoptosis, and Autophagy	4
Growth Factors as Tools in Photoreceptor Cell Regeneration and Vision Recovery	3
The Role of Nitro (NO2-), Chloro (Cl), and Fluoro (F) Substitution in the Design of Antileishmanial and Antichagasic Compounds	3
Nanocarriers for Photodynamic Therapy Intended to Cutaneous Tumors	3
Inflammatory Bowel Disease in Migrant Populations: Should we Look Even Further Back?	3
An Agathokakological Tale of Δ9-THC: Exploration of Possible Biological Targets	3
The Predominant microRNAs in β-cell Clusters for Insulin Regulation and Diabetic Control	3
Fibrinolysis in COVID-19: Impact on Clot Lysis and Modulation of Inflammation	3
Exploring the Clinical Impact of Predictive Biomarkers in Serous Ovarian Carcinomas	3
Revealing Insights into Natural Products Against mcr-1-Producing Bacteria	3
Glycogen Synthase Kinase-3 (GSK-3) Inhibitors as a New Lead for Treating Breast and Ovarian Cancer	3
The Mechanistic Role of Different Mediators in the Pathophysiology of Nephropathy: A Review	3
Digoxin and Outcomes in Patients with Heart Failure and Preserved Ejection Fraction (HFpEF) Patients: A Systematic Review and Meta- Analysis	3
Aging of Brain Related with Mitochondrial Dysfunctions	3
Regulation of Cl- Electrolyte Permeability in Epithelia by Active Traditional Chinese Medicine Monomers for Diarrhea	3
Possible Role of Wnt Signaling Pathway in Diabetic Retinopathy	3
Nanomedicine in Pancreatic Cancer: A New Hope for Treatment	3
Therapeutic and Mechanistic Approaches of Tridax Procumbens Flavonoids for the Treatment of Osteoporosis	3
Intravesical Botox for Overactive Bladder: How to Minimize Complications and Manage Failures	3
Role of Poly(ADP-ribose) Polymerase (PARP1) in Viral Infection and its Implication in SARS-CoV-2 Pathogenesis	3
Neoadjuvant Chemotherapy Before Radical Cystectomy: Why We Must Adhere?	3
Medicinal Plants Towards Modeling Skin Cancer	3
How Targeted Therapy Influence Renal Surgery for Renal Cell Carcinoma	3
An Insight into the Discovery of Potent Antifilarial Leads Against Lymphatic Filariasis	3
Nanotechnology for Targeted Drug Delivery to Treat Osteoporosis	3
Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases	3
Epigenetic Therapies and Potential Drugs for Treating Human Cancer	3
Current Perspectives of Healthy Mitochondrial Function for Healthy Neurons	3
Targeting Autophagic Pathways by Plant Natural Compounds in Cancer Treatment	3
A Comprehensive Review on Preclinical Evidence-based Neuroprotective Potential of Bacopa monnieri against Parkinson's Disease	3
Breast Cancer Resistance Protein: A Potential Therapeutic Target for Cancer	3
Role and Therapeutic Potential of RAGE Signaling in Neurodegeneration	3
Free ISG15 and Protein ISGylation Emerging in SARS-CoV-2 Infection	3
Polymer-dendrimer Hybrids as Carriers of Anticancer Agents	3
Past and Present Behçet’s Disease Animal Models	3
Dysregulation of Lysyl Oxidases Expression in Diabetic Nephropathy and Renal Cell Carcinoma	3
Trabectedin (Yondelis®) as a Therapeutic Option in Gynecological Cancers: A Focus on its Mechanisms of Action, Clinical Activity and Genomic Predictors of Drug Response	3
Potential Role of In Vitro-In Vivo Correlations (IVIVC) for the Development of Plant-Derived Anticancer Drugs	3
COVID-19 Induces Cytokine Storm and Dysfunctional Hemostasis	3
In Silico Study Examining New Phenylpropanoids Targets with Antidepressant Activity	3