Current Drug Targets

Papers
(The median citation count of Current Drug Targets is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)
ArticleCitations
Colorectal Cancer Epidemiology: Recent Trends and Impact on Outcomes120
Chitosan Nanoparticles as a Novel Drug Delivery System: A Review Article43
Characteristic of Cyclodextrins: Their Role and Use in the Pharmaceutical Technology38
Natural Products as Anticancer Agents37
Fluoroquinolones: Blessings Or Curses36
Small-molecule Antiviral Agents in Ongoing Clinical Trials for COVID-1929
Artificial Intelligence, Big Data and Machine Learning Approaches in Precision Medicine & Drug Discovery29
Targeting Enteric Neurons and Plexitis for the Management of Inflammatory Bowel Disease29
Novel Strategies to Combat the Emerging Drug Resistance in Human Pathogenic Microbes27
Strategies and Therapies for Wound Healing: A Review26
Biopolymer-based Scaffolds for Tissue Engineering Applications25
Osteoblast-n-Osteoclast: Making Headway to Osteoporosis Treatment25
Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data23
Mitochondrial Dysfunction in Huntington’s Disease: Pathogenesis and Therapeutic Opportunities22
Targeting Host Cell Proteases to Prevent SARS-CoV-2 Invasion22
Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review21
Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology20
A Comprehensive Review on Chrysin: Emphasis on Molecular Targets, Pharmacological Actions and Bio-pharmaceutical Aspects20
Antimicrobial Terpenoids as a Potential Substitute in Overcoming Antimicrobial Resistance20
Recent Progress in Stimuli-Responsive Intelligent Nano Scale Drug Delivery Systems: A Special Focus Towards pH-Sensitive Systems20
Remdesivir (GS-5734) in COVID-19 Therapy: The Fourth Chance19
Redox Interactions in Chemo/Radiation Therapy-induced Lung Toxicity; Mechanisms and Therapy Perspectives19
TL1A: A New Potential Target in the Treatment of Inflammatory Bowel Disease19
Combinational Approaches Targeting Neurodegeneration, Oxidative Stress, and Inflammation in the Treatment of Diabetic Retinopathy18
Cell-penetrating Peptide-mediated Nanovaccine Delivery18
Fibrinogen, Fibrin, and Fibrin Degradation Products in COVID-1917
COVID-19 and Renal Diseases: An Update17
Anti-VEGF Mediated Immunomodulatory Role of Phytochemicals: Scientific Exposition for Plausible HCC Treatment17
An Overview of Computer-aided Drug Design Tools and Recent Applications in Designing of Anti-diabetic Agents17
Gamma Secretase Inhibitor: Therapeutic Target via NOTCH Signaling in T Cell Acute Lymphoblastic Leukemia17
The Fate of Nanoparticles In Vivo and the Strategy of Designing Stealth Nanoparticle for Drug Delivery15
An Insight Into Mitochondrial Dysfunction and its Implications in Neurological Diseases15
Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling15
Microbial Synthesis of Gold Nanoparticles and their Application14
Kratom Dependence and Treatment Options: A Comprehensive Review of the Literature14
A Review on Recent Development of Novel Heterocycles as Acetylcholinesterase Inhibitor for the Treatment of Alzheimer’s Disease14
A Review on Rheumatoid Arthritis Interventions and Current Developments14
Review of the Biological Activity of Maslinic Acid14
Lung Pneumonitis and Fibrosis in Cancer Therapy: A Review on Cellular and Molecular Mechanisms14
GSK-3 Inhibitors as New Leads to Treat Type-II Diabetes13
Exploring Spike Protein as Potential Target of Novel Coronavirus and to Inhibit the Viability Utilizing Natural Agents13
PD1 and PD-L1 Inhibitors for the Treatment of Kidney Cancer: The Role of PD-L1 Assay13
Lipid Metabolism and Mitochondria: Cross Talk in Cancer13
Post-menopausal Osteoporosis and Probiotics13
P2X7 Receptor as a Potential Target for Major Depressive Disorder12
An Updated Review for the Diabetic Wound Healing Systems12
Targeting mTOR Signaling in Type 2 Diabetes Mellitus and Diabetes Complications12
The Gut Microbiota and Traditional Chinese Medicine: A New Clinical Frontier on Cancer12
Robotic Surgery in Inflammatory Bowel Disease12
CD47 Functionalization of Nanoparticles as a Poly(ethylene glycol) Alternative: A Novel Approach to Improve Drug Delivery11
Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson’s Disease11
Targeting Hepatic Stellate Cell Death to Reverse Hepatic Fibrosis11
The Potential Therapeutic Role of the HMGB1-TLR Pathway in Epilepsy11
Thrombosis in IBD in the Era of JAK Inhibition11
Insights into the Mechanism of the Therapeutic Potential of Herbal Monoamine Oxidase Inhibitors in Neurological Diseases11
Role of ATP-binding Cassette Transporters in Sorafenib Therapy for Hepatocellular Carcinoma: An Overview11
Overview on Thioredoxin-Interacting Protein (TXNIP): A Potential Target for Diabetes Intervention11
Antimycotic Drugs and their Mechanisms of Resistance to Candida Species11
Cyclic Nucleotides Signaling and Phosphodiesterase Inhibition: Defying Alzheimer’s Disease11
Status of Programmed Death Ligand 1 (PD-L1) by Immunohistochemistry and Scoring Algorithms11
PD-L1 Testing for Urothelial Carcinoma: Interchangeability, Reliability and Future Perspectives11
Alzheimer's Disease and β-secretase Inhibition: An Update with a Focus on Computer-aided Inhibitor Design11
Fibrotic Strictures in Crohn’s Disease: Mechanisms and Predictive Factors11
Molecular Modeling Targeting Transmembrane Serine Protease 2 (TMPRSS2) as an Alternative Drug Target Against Coronaviruses11
Antibiotic Potentiation of Natural Products: A Promising Target to Fight Pathogenic Bacteria11
Biodegradable Nanoparticles: A Recent Approach and Applications10
Nanotechnology Based Approach for Hepatocellular Carcinoma Targeting10
Antibiotic Adjuvants: A Promising Approach to Combat Multidrug Resistant Bacteria10
Anti-inflammatory Potential of GSK-3 Inhibitors10
Adenosine Dysfunction in Epilepsy and Associated Comorbidities10
Recent Advances in the Discovery of GSK-3 Inhibitors from Synthetic Origin in the Treatment of Neurological Disorders10
Management of Glioblastoma Multiforme by Phytochemicals: Applications of Nanoparticle-Based Targeted Drug Delivery System10
Current Quest in Natural Bioactive Compounds for Alzheimer’s Disease: Multi-Targeted-Designed-Ligand Based Approach with Preclinical and Clinical Based Evidence10
Implications of microRNAs in the Pathogenesis of Atherosclerosis and Prospects for Therapy10
Immunotherapy and Radiation Therapy in Renal Cell Carcinoma10
Interplay between DNA Methyltransferase 1 and microRNAs During Tumorigenesis10
Therapeutic Potential, Synthesis, Patent Evaluation and SAR Studies of Thieno[3,2-d]pyrimidine Derivatives: Recent Updates9
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing9
Herbal Medicine in the Treatment of Epilepsy9
Thioethers: An Overview9
Recent Update on the Alzheimer's Disease Progression, Diagnosis and Treatment Approaches9
Challenges with Wound Infection Models in Drug Development9
3D Printing Technology in Pharmaceutical Dosage Forms: Advantages and Challenges9
Microbubbles Contrast Agents: General Overview as Diagnostics and Therapeutic Agent9
A Review on Anti-urease Potential of Coumarins9
Anti-VEGF Therapy in Myopic CNV9
Metformin: A Promising Antidiabetic Medication for Cancer Treatment9
A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders8
Endogenous Enzyme-responsive Nanoplatforms for Anti-tumor Therapy8
Elabela Peptide: An Emerging Target in Therapeutics8
A Comprehensive Review on Liver Targeting: Emphasis on Nanotechnology- based Molecular Targets and Receptors Mediated Approaches8
Self-Assembled Micelles of Amphiphilic PEGylated Drugs for Cancer Treatment8
Facts and Myths: Efficacies of Repurposing Chloroquine and Hydroxychloroquine for the Treatment of COVID-198
Central Effects of Ivermectin in Alleviation of Covid-19-induced Dysauto-nomia8
Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities8
Vaginitis: Review on Drug Resistance8
Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause, Mechanisms Involved, and Strategies to Combat8
GSK-3 Inhibitors: A New Class of Drugs for Alzheimer’s Disease Treatment8
Tissue Factor and COVID-19: An Update8
Faecal Microbiota Transplantation in Inflammatory Bowel Disease: Current Concepts and Future Challenges8
Microtubules and Cell Division: Potential Pharmacological Targets in Cancer Therapy8
The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy8
Glycogen Synthase Kinase-3 (GSK-3) Inhibitors as a New Lead for Treating Breast and Ovarian Cancer8
New Approaches for the Treatment of Chagas Disease8
Role of GSK-3 in Cardiac Health: Focusing on Cardiac Remodeling and Heart Failure8
Bidirectional Relations Between Anxiety, Depression, and Cancer: A Review7
The Role of Bacterial Proteases in Microbe and Host-microbe Interactions7
Nutritional Support and Probiotics as a Potential Treatment of IBD7
Targeting AMPK Signaling in the Liver: Implications for Obesity and Type 2 Diabetes Mellitus7
HPV-mediated Cervical Cancer: A Systematic Review on Immunological Basis, Molecular Biology, and Immune Evasion Mechanisms7
Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches7
Pivotal Role of the Interaction Between Herbal Medicines and Gut Microbiota on Disease Treatment7
Research Progress of PARP Inhibitor Monotherapy and Combination Therapy for Endometrial Cancer7
Promising Protective Effects of Chrysin in Cardiometabolic Diseases7
The Emergence of Immune-checkpoint Inhibitors in Colorectal Cancer Therapy7
The Role of Immune and Epithelial Stem Cells in Inflammatory Bowel Disease Therapy7
Berberine Administration in Treatment of Colitis: A Review7
Free Fatty Acid Receptors as New Potential Targets in Colorectal Cancer7
Neoadjuvant Strategies Before Radical Prostatectomy for High Risk Prostate Cancer in the Era of New Hormonal Agents7
Targeting Triglyceride Metabolism for Colorectal Cancer Prevention and Therapy7
A Review on CRISPR-mediated Epigenome Editing: A Future Directive for Therapeutic Management of Cancer7
CPP-Based Bioactive Drug Delivery to Penetrate the Blood-Brain Barrier: A Potential Therapy for Glioblastoma Multiforme6
Nanosponges Encapsulated Phytochemicals for Targeting Cancer: A Review6
Insight γ-Secretase: Structure, Function, and Role in Alzheimer’s Disease6
Venom of Viperidae: A Perspective of its Antibacterial and Antitumor Potential6
Recent Advances in Psoriasis Therapy: Trends and Future Prospects6
Fibrinolysis in COVID-19: Impact on Clot Lysis and Modulation of Inflammation6
Inhibition of Virulence Factors and Biofilm Formation ofAcinetobacter Baumanniiby Naturally-derived and Synthetic Drugs6
Anti-Degenerative Effect of Melatonin on Intervertebral Disc: Protective Contribution against Inflammation, Oxidative Stress, Apoptosis, and Autophagy6
PD1/PD-L1 Axis in Uro-oncology6
Pharmacological Exploration of Triazole-based Therapeutics for Alzheimer’s Disease: An Overview6
A Comprehensive Review on Preclinical Evidence-based Neuroprotective Potential of Bacopa monnieri against Parkinson's Disease6
Exosomes in Inflammatory Bowel Disease: What Have We Learned So Far?6
Exosomes: A Novel Therapeutic Paradigm for the Treatment of Depression6
Lipidomics as Tools for Finding Biomarkers of Intestinal Pathology: From Irritable Bowel Syndrome to Colorectal Cancer6
Progress on the Mechanism for Aspirin’s Anti-tumor Effects6
Fibroblast Growth Factor: Promising Target for Schizophrenia6
Long Non-coding RNA Therapeutics: Recent Advances and Challenges6
Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead6
Histone Deacetylase Inhibitors as Cognitive Enhancers and Modifiers of Mood and Behavior6
Targeted Mitochondrial Drugs for Treatment of Ischemia-Reperfusion Injury5
Omega-3 Fatty Acid Treatment Combined with Chemotherapy to Prevent Toxicity, Drug Resistance, and Metastasis in Cancer5
Potential Targets in Constipation Research: A Review5
PD-L1 Inhibitors for the Treatment of Prostate Cancer5
The Mechanistic Role of Different Mediators in the Pathophysiology of Nephropathy: A Review5
A Review on Emerging Drug Targets in Treatment of Schizophrenia5
How can we Preserve Sexual Function after Ablative Surgery for Benign Prostatic Hyperplasia?5
MiRNA, a New Treatment Strategy for Pulmonary Fibrosis5
Drugs or Mechanical Devices for Obstructive LUTS?5
Microsatellite Instability as a Predictor of Outcomes in Colorectal Cancer in the Era of Immune-Checkpoint Inhibitors5
A Glance on the Role of Bacterial Siderophore from the Perspectives of Medical and Biotechnological Approaches5
Serotonin and Depression: Scrutiny of New Targets for Future Anti- Depressant Drug Development5
Application of Ultrasound Elastography for Assessing Intestinal Fibrosis in Inflammatory Bowel Disease: Fiction or Reality?5
Gelatin-based Targeted Delivery Systems for Tissue Engineering5
Exploring Current Role of Nanotechnology Used in Food Processing Industry to Control Food Additives and their Biochemical Mechanisms5
Molecular Signaling Pathways and Essential Metabolic Elements in Bone Remodeling: An Implication of Therapeutic Targets for Bone Diseases5
Recent Advances in Nanotechnology-Based Drug Delivery Approaches for Alzheimer disease5
Amendatory Effect of Flavonoids in Alzheimer's Disease Against Mitochondrial Dysfunction5
An Update On Proficiency of Voltage-gated Ion Channel Blockers in the Treatment of Inflammation-associated Diseases5
Elucidation of Abnormal Extracellular Regulated Kinase (ERK) Signaling and Associations with Syndromic and Non-syndromic Autism5
The Activating Receptors of Natural Killer Cells and Their Inter-Switching Potentials5
Advancements and Utilizations of Scaffolds in Tissue Engineering and Drug Delivery5
Preclinical Drug Discovery in Colorectal Cancer: A Focus on Natural Compounds5
Biomimetic Drug Delivery Systems Oriented by Biological Function in Tumor Targeting5
The Ubiquitin-Proteasome Pathway and Resistance Mechanisms Developed Against the Proteasomal Inhibitors in Cancer Cells5
Recent Progress on Apoptotic Activity of Triazoles5
Medicinal Plants Towards Modeling Skin Cancer4
Inflammatory Bowel Disease in Migrant Populations: Should we Look Even Further Back?4
A Comprehensive Review on Pellets as a Dosage Form in Pharmaceuticals4
Rediscovering Tocophersolan: A Renaissance for Nano-Based Drug Delivery and Nanotheranostic Applications4
Therapeutic Targeting of Overexpressed MiRNAs in Cancer Progression4
The Regulatory Role of Rho GTPases and their Substrates in Osteoclastogenesis4
Toxic, Genotoxic and Teratogenic Effects of Ibuprofen and its Derivatives4
Aging of Brain Related with Mitochondrial Dysfunctions4
Lipid-based Nanocarriers Loaded with Taxanes for the Management of Breast Cancer: Promises and Challenges4
Therapeutic and Mechanistic Approaches of Tridax Procumbens Flavonoids for the Treatment of Osteoporosis4
Past and Present Behçet’s Disease Animal Models4
Nanomedicine in Pancreatic Cancer: A New Hope for Treatment4
Role and Therapeutic Potential of RAGE Signaling in Neurodegeneration4
Parkinson’s Disease: A Current Perspectives on Parkinson’s Disease and Key Bioactive Natural Compounds as Future Potential Drug Candidates4
Role of γ-Secretase Inhibitors for the Treatment of Diverse Disease Conditions through Inhibition of Notch Signaling Pathway4
Targeted Drug Delivery Using Tuftsin-bearing Liposomes: Implications in the Treatment of Infectious Diseases and Tumors4
Dysregulation of Lysyl Oxidases Expression in Diabetic Nephropathy and Renal Cell Carcinoma4
In Silico Study Examining New Phenylpropanoids Targets with Antidepressant Activity4
Digoxin and Outcomes in Patients with Heart Failure and Preserved Ejection Fraction (HFpEF) Patients: A Systematic Review and Meta- Analysis4
Nanotechnology for Targeted Drug Delivery to Treat Osteoporosis4
Revealing Insights into Natural Products Against mcr-1-Producing Bacteria4
Free ISG15 and Protein ISGylation Emerging in SARS-CoV-2 Infection4
Breast Cancer Resistance Protein: A Potential Therapeutic Target for Cancer4
NLRP3: A Promising Therapeutic Target for Inflammatory Bowel Disease4
An Insight into Diverse Activities and Targets of Flavonoids4
miRNAs as Modulators of Cholesterol in Breast Cancer Stem Cells: An Approach to Overcome Drug Resistance in Cancer4
Bacteriophage Cocktail Can Effectively Control Salmonella Biofilm on Gallstone and Tooth Surfaces4
Phytotherapy and Herbal Medicines for Kidney Stones4
COVID-19 Induces Cytokine Storm and Dysfunctional Hemostasis4
A Comprehensive Review on Nanomedicine: Promising Approach for Treatment of Brain Tumor through Intranasal Administration4
Target Genetic Abnormalities for the Treatment of Colon Cancer and Its Progression to Metastasis4
Exploring the SARS-Cov-2 Main Protease (Mpro) and RdRp Targets by Updating Current Structure-based Drug Design Utilizing Co-crystals to Combat COVID-194
Proteasome as a Drug Target in Trypanosomatid Diseases3
Emerging Role of Circular RNAs in Kidney Diseases in Nephrology3
A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer’s Disease3
Bugs as Drugs: Understanding the Linkage between Gut Microbiota and Cancer Treatment3
How Targeted Therapy Influence Renal Surgery for Renal Cell Carcinoma3
Adipocyte Fatty Acid Binding Protein (A-FABP) as a Potential New Therapeutic Target for the Treatment of Obesity - Associated Cancers3
Potential Phytochemicals for Prevention of Familial Breast Cancer with BRCA Mutations3
Strategies for Controlling Biofilm-forming Microbial Pathogens on Biotic and Abiotic Surfaces3
Potential Role of In Vitro-In Vivo Correlations (IVIVC) for the Development of Plant-Derived Anticancer Drugs3
The Role of Nitro (NO2-), Chloro (Cl), and Fluoro (F) Substitution in the Design of Antileishmanial and Antichagasic Compounds3
Current Perspectives of Healthy Mitochondrial Function for Healthy Neurons3
Nanocarriers for Photodynamic Therapy Intended to Cutaneous Tumors3
An Agathokakological Tale of Δ9-THC: Exploration of Possible Biological Targets3
Current Debates on Etiopathogenesis and Treatment Strategies for Vitiligo3
Application of Poloxamers for the Development of Drug Delivery System to Treat Leishmaniasis: A Review3
Phosphodiesterases 5 Inhibitors and Erectile Dysfunction Recovery after Pelvic Surgery: Future Perspectives for New Drugs and New Formulations3
Vascular Endothelial Dysfunction in Ischemic Reperfusion Injury Needs Constant Updating3
A Comprehensive Insight on Pharmaceutical Co-crystals for Improvement of Aqueous Solubility3
Bacterial Metalo-Aminopeptidases as Targets in Human Infectious Diseases3
Diabetic Nephropathy: Pathogenesis to Cure3
Therapeutic Potential of Targeting Transforming Growth Factor-beta (TGF-β) and Programmed Death-ligand 1 (PD-L1) in Pancreatic Cancer3
A Review on Molecular Mechanisms and Patents of Marine-derived Anti-thrombotic Agents3
Exploring AT2R and its Polymorphism in Different Diseases: An Approach to Develop AT2R as a Drug Target beyond Hypertension3
Role of Poly(ADP-ribose) Polymerase (PARP1) in Viral Infection and its Implication in SARS-CoV-2 Pathogenesis3
Nanoformulations - Insights Towards Characterization Techniques3
Intravesical Botox for Overactive Bladder: How to Minimize Complications and Manage Failures3
Natural Bioactive Compounds as Emerging Therapeutic Molecules Against Breast Cancer: Emphasis on the Role of Phytoestrogens3
Neoadjuvant Chemotherapy Before Radical Cystectomy: Why We Must Adhere?3
Polymer-dendrimer Hybrids as Carriers of Anticancer Agents3
The Role of Type 2 Fibroblast Growth Factor in Periodontal Therapy3
Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases3
Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases3
Emerging Trends and Future Challenges of Nanovaccine Delivery via Nasal Route3
Possible Role of Wnt Signaling Pathway in Diabetic Retinopathy3
Canonical Wnt/Beta-Catenin Signaling Network as Emerging Signaling Cascade for Therapeutic Intervention in Chronic Renal Disease3
Do Drugs Work for ΟΑΒ Following Prostate Cancer Surgery2
Oncostatin M: Risks and Benefits of a Novel Therapeutic Target for Atherosclerosis2
A Review on Development and Characterization of a Cost-effective Targeted Quality-driven Antimalarial Product with an Emphasis on Phytosomes2
Neurological Complications of SARS-CoV-2 Infection and COVID-19 Vaccines: From Molecular Mechanisms to Clinical Manifestations2
The Extracapsular Lymph Node Extension Predicts Outcomes in Colorectal Cancer: A Short Review2
Cytotoxic Flavokawain B Inhibits the Growth and Metastasis of Hepatocellular Carcinoma through UCK2 Modulation of the STAT3/Hif-1α/VEGF Signalling Pathway2
Deciphering Role of Cytokines for Therapeutic Strategies Against Rheumatoid Arthritis2
Viaminate Inhibits Propionibacterium Acnes-induced Abnormal Proliferation and Keratinization of HaCat Cells by Regulating the S100A8/S100A9- MAPK Cascade2
Regulation of Tumor Immune Microenvironment by Sphingolipids and Lysophosphatidic Acid2
Cerebrovascular Complications of Diabetes: SGLT-2 Inhibitors as a Promising Future Therapeutics2
Biomarkers for Early Detection of Colitis-associated Colorectal Cancer - Current Concepts, Future Trends2
Recent Advances in the Prevention and Management of Monkeypox Viral Infection in Humans2
Advances in Early Detection of Colorectal Cancer: A Focus on Non-invasive Biomarkers2
Superoxide Dismutase Inhibitors against Malaria, Leishmaniasis, and Chagas Disease: Systematic Review2
Application and Future Prospect of Extracellular Matrix Targeted Nanomaterials in Tumor Theranostics2
Mesenchymal Stem Cells and Cancer Stem Cells: An Overview of Tumor- Mesenchymal Stem Cell Interaction for Therapeutic Interventions2
Therapeutic Potential of HDAC Inhibitors in the Treatment of Cardiac Diseases: A Short Review2
0.044105052947998