Current Drug Targets

Article	Citations
Cell Entry and Unusual Replication of SARS-CoV-2	44
SARS-Coronavirus 2, A Metabolic Reprogrammer: A Review in the Context of the Possible Therapeutic Strategies	41
The Marburg Virus Outbreak in West Africa	37
Review on the Drug Intolerance and Vaccine Development for the Leishmaniasis	35
Unfurling the Potential of Antiviral Agents Aimed for RNA Virus Ailment	35
The Development of the Combination Drug Leukovir® Tablets for the Treatment of Multiple Sclerosis: A Comprehensive Review	34
Polymeric Micelle-Based Nanogels as Emerging Drug Delivery Systems in Breast Cancer Treatment: Promises and Challenges	33
Current Research Trends in Cytokine Storm: A Scientometric Study	33
Metformin: A Promising Antidiabetic Medication for Cancer Treatment	32
Possible Applications of Azurin, a Copper-Containing Protein, in Cancer Treatment: Prospects and Challenges	30
Meet the Regional Editor	29
Betaine, a Potential Therapeutic Alternative for the Treatment of Depression	28
Xerostomia: Advances and Challenges in Drug Development	26
Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery	25
Envisioning Glucose Transporters (GLUTs and SGLTs) as Novel Intervention against Cancer: Drug Discovery Perspective and Targeting Approach	24
Targeted Delivery Strategies of Herbal-Based Nanogels: Advancements and Applications	24
COVID-19 Induces Cytokine Storm and Dysfunctional Hemostasis	23
Exploring the Potential Molecular Mechanisms of Berberine against Gastric Cancer Liver Metastasis Based on Network Pharmacology and Bioinformatics	23
Bile Acid Application in Cell-Targeting for Molecular Receptors in Relation to Hearing: A Comprehensive Review	23
Targeting Neurodegeneration: The Emerging Role of Hybrid Drugs	23
An Updated Insight into Phytomolecules and Novel Approaches used in the Management of Breast Cancer	22
Investigating Alternative Treatments for Dyslipidemia Using Bioactive Compounds Derived from Kiwifruit (Actinidia chinensis): A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulati	21
Targets Involved in the Pharmacology of Bothrops Snakebite: Statu Quo and Future Perspectives	21
An Overview of Research Advances in Oncology Regarding the Transcription Factor ATF4	20
RMNet: An RNA m6A Cross-species Methylation Detection Method for Nanopore Sequencing	20

An Explainable Deep Learning Model for Clathrin Protein Prediction Using a DCT-Enhanced Position-Specific Scoring Matrix	19
Diabetic Nephropathy: Pathogenesis to Cure	19
The Role of Leukocyte Immunoglobulin-Like Receptors Focusing on the Therapeutic Implications of the Subfamily B2	19
IL-17 Antagonists as a Promising Therapeutic Modality for Hidradenitis Suppurativa	18
Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials	18
ClpP Peptidase as a Plausible Target for the Discovery of Novel Antibiotics	17
Innovations in Antimalarial Drug Discovery: New Targets and Leads	17
Robust Association of Breast Cancer Co-morbidity Using Subtype-specific Expressed Genes	16
Exploring the Efficient Natural Products for the Therapy of Parkinson’s Disease via Drosophila Melanogaster (Fruit Fly) Models	16
Rho Kinase (ROCK) Inhibitors for the Treatment of Glaucoma	15
Transcription Factors in Brain Regeneration: A Potential Novel Therapeutic Target	15
A Comprehensive Insight on Pharmaceutical Co-crystals for Improvement of Aqueous Solubility	15
Transcending Molecules: Paving the Way from Lab to Life in Drug Transport Innovation	15
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing	15
Mitochondria-Targeted Nanoformulations: New Therapeutic Strategies and Opportunities for Cancer Immunotherapy	15
Prospection of Microfluidics for Local Drug Delivery	14
Multi-target Compounds against Trypanosomatid Parasites and Mycobacterium tuberculosis	14
Phytovesicular Nanoconstructs for Advanced Delivery of Medicinal Metabolites: An In-Depth Review	13
Targeting Creatine and Creatine Kinase in Cancer: Exploring Potential Therapeutic Strategies	13
Recent Advances in the Development of Alpha-Glucosidase and Alpha-Amylase Inhibitors in Type 2 Diabetes Management: Insights from In silico to In vitro Studies	12
Recent Advances in Biomedical Applications of Mannans and Xylans	12
RAAS Overactivation and Mitochondrial Damage Signaling as Key Players in Lethal COVID-19	12
A Review on the Current Status of Homeopathy in the Clinical Manage-ment of Cancer	12
Potential Targets in Constipation Research: A Review	12
The Recent Advances in the Function and Mechanism of Caveolin-1 in Retinal Neovascularization	12
Multi-targeted Mechanisms of Erianin against Pancreatic Ductal Adenocarcinoma: Integrative Network Pharmacology, Bioinformatics, and Experimental Validation	12
Identification of Natural Inhibitors against the Mycobacterium tuberculosis Proteasome: Computational Study	12
Effect of Rotenone on the Neurodegeneration among Different Models	12
Signaling Dynamics in Osteogenesis: Unraveling Therapeutic Targets for Bone Generation	12
Evaluating the Biological Activities of Oleanolic Acid and Apigenin in a 2-in-1 Nanoparticulate System: A Proof-of-concept Study	11
Bidirectional Communication of Estrogen in Gut-Brain Axis: Evidence from Preclinical and Clinical Studies	11
Microbial Proteases: Pioneering Tools for Modern Therapeutic Innovations	11
Novel Approaches to Diagnosing and Treating Non-alcoholic Fatty Liver Disease: Opportunities and Accomplishments	11
MiRNAs Overexpression and Their Role in Breast Cancer: Implications for Cancer Therapeutics	11
Proteasome as a Drug Target in Trypanosomatid Diseases	10
Exploring the SARS-Cov-2 Main Protease (Mpro) and RdRp Targets by Updating Current Structure-based Drug Design Utilizing Co-crystals to Combat COVID-19	10
Targeted Covalent Inhibition: A Prospective Way to Develop Novel HSP90 C-terminal Inhibitor	10
An Exploratory Review on the Hypoglycemic Action of Unani Anti-diabetic Drugs via Possible Modulation of Gut Microbiota	10
Emerging Threats and Challenges of Monkeypox Virus: Exploration and Sensitivity	10
FGMA: A Functional Group-enhanced Deep Learning Method for Drug Toxicity Prediction	10
Meet the Editorial Board Member	10
Statin Therapy and C-reactive Protein in Patients with Kidney Disease: A Systematic Review and Meta-analysis of Randomized Clinical Trials	9
Skin Microbial Composition and Genetic Mutation Analysis in Precision Medicine for Epidermolysis Bullosa	9
Nanoformulations - Insights Towards Characterization Techniques	9
Advances in Understanding and Managing Alzheimer's Disease: From Pathophysiology to Innovative Therapeutic Strategies	9
Co-Crystallization: A Novel Technique to Improvise the Pharmaceutical Characteristics of API’s	9
Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead	9
Multitarget Compounds for Neglected Diseases: A Review	8
Proteases and Osteoporosis: A Comprehensive Review of Their Role in Bone Health	8
Possible Role of Wnt Signaling Pathway in Diabetic Retinopathy	8

Meet the Associate Editorial Board Member	8
Sodium-glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy	8
Effects of Kefir Consumption on Cardiometabolic Risk Factors: A Systematic Review and Meta-analysis of Randomized Controlled Trials	8
Advances in Cysteine Protease B Inhibitors for Leishmaniasis Treatment	8
Diabetic Wound Healing: Factors, Mechanisms, and Treatment Strategies Using Herbal Components	8
Vaccine for Targeted Therapy of Lung Cancer: Advances and Developments	8
Superoxide Dismutase Inhibitors against Malaria, Leishmaniasis, and Chagas Disease: Systematic Review	8
A Review of Amylin Peptide Receptor Activators for Obesity Pharmacotherapy	8
Sepsis-Associated Brain Dysfunction: Mechanisms, Clinical Insights, and Therapeutic Strategies	8
Investigating the Mechanism of Astragalus mongholicus-Mediated Treatment of Silicosis in Mice from the Perspective of Alternative Splicing	8
Acknowledgements to Reviewers	8
Precision Targeting of BET Proteins - Navigating Disease Pathways, Inhibitor Insights, and Shaping Therapeutic Frontiers: A Comprehensive Review	8
CRISPR-Cas9 Gene Editing: Promising Therapeutics for HPV-driven Cervical Cancer	7
Long Non-coding RNAs in Non-small Cell Lung Carcinoma: Regulatory Mechanisms, Diagnostic Potential, and Therapeutic Perspectives	7
Anti-Degenerative Effect of Melatonin on Intervertebral Disc: Protective Contribution against Inflammation, Oxidative Stress, Apoptosis, and Autophagy	7
An Update on the Emerging Role of Wnt/β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis	7
Meet the Editorial Board Member	7
Systematic Identification and Characterization of Causal Risk Genes Implicated in Colorectal Cancer by Integrating GWAS, eQTL, and mQTL Data	7
Beneficial Outcomes of Cancer Therapeutic Modalities Based on Targeting Apoptosis	7
The Resurgence of H3N2 in India: Is it Life-threatening?	7
Differential Drug Permeability across Biofilms	7
Surface Functionalized Lipid Nanoparticles in Promoting Therapeutic Outcomes: An Insight View of the Dynamic Drug Delivery System	7
The Mechanistic Role of Different Mediators in the Pathophysiology of Nephropathy: A Review	7
Beyond PD-1: Expanding the Landscape of Immune Checkpoint Targets in Cancer Therapy	6
(E)-Labda dial-Loaded Nanoparticles for Triple Negative Breast Cancer	6
Roadmap to Pyruvate Kinase M2 Modulation - A Computational Chronicle	6
Meet the Editorial Board Member	6
Meet the Regional Editor	6
An Update On Proficiency of Voltage-gated Ion Channel Blockers in the Treatment of Inflammation-associated Diseases	6
Two Decades Rituximab Therapy in Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis	6
Free ISG15 and Protein ISGylation Emerging in SARS-CoV-2 Infection	6
Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation of Mucuna pruriens for Parkinson's Disease Treatment	6
Cellular Therapeutics for Chronic Wound Healing: Future for Regenerative Medicine	6
Beyond AlphaFold: Charting the Future of AI in Protein Structure Prediction	6
Mechanistic Approach to Ferroptosis in Cancer and Neurological Diseases	6
Meet the Editorial Board Member	6
Polypharmacology-Driven Discovery and Design of Highly Selective, Dual and Multitargeting Inhibitors of Mycobacterium tuberculosis - A Review	6
E2 Protein of Chikungunya Virus: A Narrative Review of Its Potential as a Therapeutic Target	6
Bidirectional Relations Between Anxiety, Depression, and Cancer: A Review	6
FAVAR-GAT: A Hybrid Temporal-structural Model for Drug-target Binding Affinity Prediction	6
A Comprehensive Review on Therapeutic Potential of a Natural Anthraquinone Derivative Emodin in Brain-related Disorders	6
Targeted Regulation of Intracellular Signal Transduction: A New Paradigm for Stimulation of Neurogenesis in Alzheimer's Disease	6
Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies	6
An Insight into Diverse Activities and Targets of Flavonoids	6
NLRP3: A Promising Therapeutic Target for Inflammatory Bowel Disease	6
Comparative Analysis of Circular RNAs Expression and Function between Aortic and Intracranial Aneurysms	5
Long Non-coding RNA Therapeutics: Recent Advances and Challenges	5
Gastrointestinal System: COVID-19 and Potential Mechanisms Associated with Coagulopathy	5
A Review on CRISPR-mediated Epigenome Editing: A Future Directive for Therapeutic Management of Cancer	5
The Therapeutic Potential of Targeting Hsp90-Cdc37 Interactions in Several Diseases	5
Endogenous Ligands of TLR4 in Microglia: Potential Targets for Related Neurological Diseases	5
Role of BMP-7 in Cardiovascular Diseases: From Molecular Mechanisms to Therapeutic Horizons	5
A Comprehensive Review on Preclinical Evidence-based Neuroprotective Potential of Bacopa monnieri against Parkinson's Disease	5
Hybrid-Compounds Against Trypanosomiases	5
Molecular Glues for Undruggable Targets: Mechanisms, Clinical Applications, and AI-driven Design	5
LncRNA HAGLROS: A Vital Oncogenic Propellant in Various Human Cancers	5
Chronic Inflammation (A Silent Killer) – Molecular Mechanisms and Emerging Therapeutic Approaches	5
A Review on the Recent Advancements and Artificial Intelligence in Tablet Technology	5
Phytoconstituents-Based Nanotherapeutic Approach for the Effective Management of Joint Inflammatory Condition: Arthritis	5
PTP1B Inhibitors for Type 2 Diabetes: From Natural Products, Synthetic Inhibitors, and Multi-Target Drug Design Strategies to Clinical Translation	5
A Comprehensive Review on Nanomedicine: Promising Approach for Treatment of Brain Tumor through Intranasal Administration	4
A Comprehensive Review on Liver Targeting: Emphasis on Nanotechnology- based Molecular Targets and Receptors Mediated Approaches	4
Meet the Section Editor	4
Microbial Synthesis of Gold Nanoparticles and their Application	4
Digoxin and Outcomes in Patients with Heart Failure and Preserved Ejection Fraction (HFpEF) Patients: A Systematic Review and Meta- Analysis	4
Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases	4
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis	4
Extracellular Vesicles from Stromal Vascular Fraction of Human Adipose Tissue in the Development of Non-antibiotic Therapy	4
Role of Artificial Intelligence in Nanomedicine and Organ-specific Therapy: An Updated Review	4
Advances in Protein-Ligand Binding Affinity Prediction via Deep Learning: A Comprehensive Study of Datasets, Data Preprocessing Techniques, and Model Architectures	4
Recent Progress and Challenges in Clinical Translation of Nanomedicines in Diagnosis and Treatment of Lung Cancer	4
Comprehensive Analysis of Omicron Subvariants: EG.5 Rise, Vaccination Strategies, and Global Impact	4
Antiviral Potential of Traditional Unani Medicine with Special Emphasis on Dengue: A Review	4
Nano Architect-Based Targeted Delivery Systems for Diabetic Nephropathy: A Review	4
Crucial Role of microRNAs as New Targets for Amelogenesis Disorders Detection	4
Toxic, Genotoxic and Teratogenic Effects of Ibuprofen and its Derivatives	4
Strategies for Treatment of Thyroid Cancer	4
Role of Vitamins in Therapeutic and Targeting Approaches for Prostate Cancer: An Overview	4
BRD4 Protein as a Target for Lung Cancer and Hematological Cancer Therapy: A Review	4
Quorum Sensing and its Inhibition in Pseudomonas aeruginosa: Molecular Targets and Mode of Action	4

Promising New Targets for the Treatment of Infections Caused by Acinetobacter baumannii: A Review	4
Therapeutic Potential of Targeting Transforming Growth Factor-beta (TGF-β) and Programmed Death-ligand 1 (PD-L1) in Pancreatic Cancer	4
Cisplatin-Based Combination Therapy for Enhanced Cancer Treatment	4
Structural Modifications in Chitosan Polymer Carries Synergistic Transfection in Drug Targeting	4
Deferoxamine Interference in Fibro-inflammation: Additional Action in Control of Obese Adipose Tissue Dysfunction	4
Antiobesity Drug Discovery Research: In vitro Models for Shortening the Drug Discovery Pipeline	4
Innovative Strategies and Advances in Drug Delivery Systems to Address Poor Solubility: A Comprehensive Review	4
Potential Target of CDK6 Signaling Pathway for Cancer Treatment	4
The Clinical Safety and Efficacy of Targeted PD-L1 Therapy with Durvalumab in Solid Tumors	4
DRP1 Association in Inflammation and Metastasis: A Review	3
The Marriage between Nanotechnology and Stem Cells Secretome for COPD	3
Tissue Factor and COVID-19: An Update	3
Therapeutic Potential of Scorpion Venom Proteins: Innovations in Cancer Treatment and Future Directions	3
Biomarkers and Treatment Strategies for Breast Cancer Recurrence	3
Compounds Multi-targets against Neglected Diseases	3
Microtubules and Cell Division: Potential Pharmacological Targets in Cancer Therapy	3
Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana	3
Estimating the Survival Rate in Glioblastoma Multiforme Patients who Received a Peptide Vaccine: A Systematic Review and Meta-analysis	3
Deciphering the Function of New Therapeutic Targets and Prospective Biomarkers in the Management of Psoriasis	3
HPV-mediated Cervical Cancer: A Systematic Review on Immunological Basis, Molecular Biology, and Immune Evasion Mechanisms	3
Current Situation on Diabetes Management: New Weapons Fighting the Disease in 2025	3
Targeting SERCA2 in Anti-Tumor Drug Discovery	3
The Potential of Mur Enzymes as Targets for Antimicrobial Drug Discovery	3
Targeting AMPK Signaling in the Liver: Implications for Obesity and Type 2 Diabetes Mellitus	3
An Insight into Hepatitis C Virus: In Search of Promising Drug Targets	3
The Role of Host-Cellular Responses in COVID-19 Endothelial Dysfunction	3
Development of Novel Intravesical Formulation for Bladder Retention Targeting Bladder Disorders	3
Investigational Agents Targeting SGLT1 and SGLT2 in the Treatment of Type 2 Diabetes Mellitus	3
Bee Venom and Cancer: A Mini-review Focusing on Melittin Antitumoral Effects	3
Novel Targets and Drug Delivery System in the Treatment of Postoperative Pain: Recent Studies and Clinical Advancement	3
Fibrinolysis in COVID-19: Impact on Clot Lysis and Modulation of Inflammation	3
Cytokeratin 8 as a Novel Therapeutic Target in Type 2 Diabetes Mellitus: Suppression of Hepatic Glycogen Synthesis via IRS1/PI3K/Akt/GSK3β Signaling	3
Recent Advances in the Prevention and Management of Monkeypox Viral Infection in Humans	3
Clinical Deployment of Interpretable AI: Bridging Routine Clinical Tests and Proteomic Signatures for Preeclampsia Risk Stratification	3
In vitro Evaluation of Memantine and Nicotinamide Combination for Synergistic Cytotoxicity in U87MG Glioblastoma Cells	3
A Review on Recent Development of Novel Heterocycles as Acetylcholinesterase Inhibitor for the Treatment of Alzheimer’s Disease	3
Targeting the cGAS–STING Pathway in Gastrointestinal Cancers: Modulating Tumor-associated Inflammation for Therapeutic Effect	3
Combinational Approaches Targeting Various Aspects Involved in Intestinal Barrier Dysfunction-Induced Anxiety	3
Tebentafusp as a Promising Drug for the Treatment of Uveal Melanoma	3
Advancing Amyloid Aggregation Research: A Focus on Innovative Therapies, Molecular Modeling and Nano-Delivery Systems in Alzheimer’s Disease	3
In Vivo Models of Steroid-Induced Intraocular Hypertension	3
Redox Interactions in Chemo/Radiation Therapy-induced Lung Toxicity; Mechanisms and Therapy Perspectives	3
SGK-1 Signalling Pathway is a Key Factor in Cell Survival in Ischemic Injury	3