Current Drug Targets

Article	Citations
Cell Entry and Unusual Replication of SARS-CoV-2	50
Unfurling the Potential of Antiviral Agents Aimed for RNA Virus Ailment	46
The Marburg Virus Outbreak in West Africa	46
The Development of the Combination Drug Leukovir® Tablets for the Treatment of Multiple Sclerosis: A Comprehensive Review	43
Current Research Trends in Cytokine Storm: A Scientometric Study	38
Metformin: A Promising Antidiabetic Medication for Cancer Treatment	36
Possible Applications of Azurin, a Copper-Containing Protein, in Cancer Treatment: Prospects and Challenges	35
Polymeric Micelle-Based Nanogels as Emerging Drug Delivery Systems in Breast Cancer Treatment: Promises and Challenges	34
Review on the Drug Intolerance and Vaccine Development for the Leishmaniasis	33
Meet the Regional Editor	33
Xerostomia: Advances and Challenges in Drug Development	30
Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery	28
Exploring the Potential Molecular Mechanisms of Berberine against Gastric Cancer Liver Metastasis Based on Network Pharmacology and Bioinformatics	27
Targeted Delivery Strategies of Herbal-Based Nanogels: Advancements and Applications	27
Envisioning Glucose Transporters (GLUTs and SGLTs) as Novel Intervention against Cancer: Drug Discovery Perspective and Targeting Approach	27
Betaine, a Potential Therapeutic Alternative for the Treatment of Depression	25
Targeting Neurodegeneration: The Emerging Role of Hybrid Drugs	25
COVID-19 Induces Cytokine Storm and Dysfunctional Hemostasis	24
RMNet: An RNA m6A Cross-species Methylation Detection Method for Nanopore Sequencing	23
Bile Acid Application in Cell-Targeting for Molecular Receptors in Relation to Hearing: A Comprehensive Review	23
An Updated Insight into Phytomolecules and Novel Approaches used in the Management of Breast Cancer	22
Investigating Alternative Treatments for Dyslipidemia Using Bioactive Compounds Derived from Kiwifruit (Actinidia chinensis): A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulati	21
Targets Involved in the Pharmacology of Bothrops Snakebite: Statu Quo and Future Perspectives	21
An Overview of Research Advances in Oncology Regarding the Transcription Factor ATF4	20
Diabetic Nephropathy: Pathogenesis to Cure	20

Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials	20
An Explainable Deep Learning Model for Clathrin Protein Prediction Using a DCT-Enhanced Position-Specific Scoring Matrix	20
IL-17 Antagonists as a Promising Therapeutic Modality for Hidradenitis Suppurativa	19
Robust Association of Breast Cancer Co-morbidity Using Subtype-specific Expressed Genes	17
Innovations in Antimalarial Drug Discovery: New Targets and Leads	17
Mitochondria-Targeted Nanoformulations: New Therapeutic Strategies and Opportunities for Cancer Immunotherapy	17
Exploring the Efficient Natural Products for the Therapy of Parkinson’s Disease via Drosophila Melanogaster (Fruit Fly) Models	17
A Comprehensive Insight on Pharmaceutical Co-crystals for Improvement of Aqueous Solubility	16
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing	16
Rho Kinase (ROCK) Inhibitors for the Treatment of Glaucoma	16
The Role of Leukocyte Immunoglobulin-Like Receptors Focusing on the Therapeutic Implications of the Subfamily B2	16
Molecular Docking and Dynamics Simulations of Natural Limonoids Interacting with the Nipah Virus Attachment Glycoprotein	15
ClpP Peptidase as a Plausible Target for the Discovery of Novel Antibiotics	15
Transcription Factors in Brain Regeneration: A Potential Novel Therapeutic Target	15
Multi-target Compounds against Trypanosomatid Parasites and Mycobacterium tuberculosis	14
Targeting Creatine and Creatine Kinase in Cancer: Exploring Potential Therapeutic Strategies	14
Transcending Molecules: Paving the Way from Lab to Life in Drug Transport Innovation	14
Prospection of Microfluidics for Local Drug Delivery	14
Recent Advances in Biomedical Applications of Mannans and Xylans	13
Recent Advances in the Development of Alpha-Glucosidase and Alpha-Amylase Inhibitors in Type 2 Diabetes Management: Insights from In silico to In vitro Studies	13
Potential Targets in Constipation Research: A Review	13
Phytovesicular Nanoconstructs for Advanced Delivery of Medicinal Metabolites: An In-Depth Review	13
Effect of Rotenone on the Neurodegeneration among Different Models	13
Identification of Natural Inhibitors against the Mycobacterium tuberculosis Proteasome: Computational Study	12
Multi-targeted Mechanisms of Erianin against Pancreatic Ductal Adenocarcinoma: Integrative Network Pharmacology, Bioinformatics, and Experimental Validation	12
RAAS Overactivation and Mitochondrial Damage Signaling as Key Players in Lethal COVID-19	11
Novel Approaches to Diagnosing and Treating Non-alcoholic Fatty Liver Disease: Opportunities and Accomplishments	11
Signaling Dynamics in Osteogenesis: Unraveling Therapeutic Targets for Bone Generation	11
A Review on the Current Status of Homeopathy in the Clinical Manage-ment of Cancer	11
The Recent Advances in the Function and Mechanism of Caveolin-1 in Retinal Neovascularization	11
MiRNAs Overexpression and Their Role in Breast Cancer: Implications for Cancer Therapeutics	10
An Exploratory Review on the Hypoglycemic Action of Unani Anti-diabetic Drugs via Possible Modulation of Gut Microbiota	10
Microbial Proteases: Pioneering Tools for Modern Therapeutic Innovations	10
Bidirectional Communication of Estrogen in Gut-Brain Axis: Evidence from Preclinical and Clinical Studies	10
Evaluating the Biological Activities of Oleanolic Acid and Apigenin in a 2-in-1 Nanoparticulate System: A Proof-of-concept Study	10
Meet the Editorial Board Member	10
Statin Therapy and C-reactive Protein in Patients with Kidney Disease: A Systematic Review and Meta-analysis of Randomized Clinical Trials	9
Proteasome as a Drug Target in Trypanosomatid Diseases	9
Hawthorn (Crataegus Species): Phytochemical Insights and Cardiotonic Mechanisms in Cardiovascular Health- A Comprehensive Review	9
Blockade of the GDF15/GFRAL Axis: Translational Advances in Cachexia, Immune Suppression, and Beyond	9
Multitarget Compounds for Neglected Diseases: A Review	9
FGMA: A Functional Group-enhanced Deep Learning Method for Drug Toxicity Prediction	9
Emerging Threats and Challenges of Monkeypox Virus: Exploration and Sensitivity	9
Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead	9
Nanoformulations - Insights Towards Characterization Techniques	9
Diabetic Wound Healing: Factors, Mechanisms, and Treatment Strategies Using Herbal Components	9
Targeted Covalent Inhibition: A Prospective Way to Develop Novel HSP90 C-terminal Inhibitor	9
Co-Crystallization: A Novel Technique to Improvise the Pharmaceutical Characteristics of API’s	9
Advances in Understanding and Managing Alzheimer's Disease: From Pathophysiology to Innovative Therapeutic Strategies	9
Skin Microbial Composition and Genetic Mutation Analysis in Precision Medicine for Epidermolysis Bullosa	9

Effects of Kefir Consumption on Cardiometabolic Risk Factors: A Systematic Review and Meta-analysis of Randomized Controlled Trials	9
Systematic Identification and Characterization of Causal Risk Genes Implicated in Colorectal Cancer by Integrating GWAS, eQTL, and mQTL Data	8
Investigating the Mechanism of Astragalus mongholicus-Mediated Treatment of Silicosis in Mice from the Perspective of Alternative Splicing	8
Advances in Cysteine Protease B Inhibitors for Leishmaniasis Treatment	8
Superoxide Dismutase Inhibitors against Malaria, Leishmaniasis, and Chagas Disease: Systematic Review	8
Sepsis-Associated Brain Dysfunction: Mechanisms, Clinical Insights, and Therapeutic Strategies	8
Possible Role of Wnt Signaling Pathway in Diabetic Retinopathy	8
Meet the Associate Editorial Board Member	8
Long Non-coding RNAs in Non-small Cell Lung Carcinoma: Regulatory Mechanisms, Diagnostic Potential, and Therapeutic Perspectives	8
Proteases and Osteoporosis: A Comprehensive Review of Their Role in Bone Health	8
A Review of Amylin Peptide Receptor Activators for Obesity Pharmacotherapy	8
Vaccine for Targeted Therapy of Lung Cancer: Advances and Developments	8
Acknowledgements to Reviewers	8
Precision Targeting of BET Proteins - Navigating Disease Pathways, Inhibitor Insights, and Shaping Therapeutic Frontiers: A Comprehensive Review	7
Surface Functionalized Lipid Nanoparticles in Promoting Therapeutic Outcomes: An Insight View of the Dynamic Drug Delivery System	7
Differential Drug Permeability across Biofilms	7
Sodium-glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy	7
CRISPR-Cas9 Gene Editing: Promising Therapeutics for HPV-driven Cervical Cancer	7
Roadmap to Pyruvate Kinase M2 Modulation - A Computational Chronicle	6
Meet the Editorial Board Member	6
Polypharmacology-Driven Discovery and Design of Highly Selective, Dual and Multitargeting Inhibitors of Mycobacterium tuberculosis - A Review	6
FAVAR-GAT: A Hybrid Temporal-structural Model for Drug-target Binding Affinity Prediction	6
Meet the Editorial Board Member	6
The Mechanistic Role of Different Mediators in the Pathophysiology of Nephropathy: A Review	6
An Update on the Emerging Role of Wnt/β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis	6
(E)-Labda dial-Loaded Nanoparticles for Triple Negative Breast Cancer	6
Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies	6
An Insight into Diverse Activities and Targets of Flavonoids	6
Cellular Therapeutics for Chronic Wound Healing: Future for Regenerative Medicine	6
Beyond AlphaFold: Charting the Future of AI in Protein Structure Prediction	6
Meet the Editorial Board Member	6
Mechanistic Approach to Ferroptosis in Cancer and Neurological Diseases	6
A Comprehensive Review on Therapeutic Potential of a Natural Anthraquinone Derivative Emodin in Brain-related Disorders	6
Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation of Mucuna pruriens for Parkinson's Disease Treatment	6
Meet the Regional Editor	6
An Update On Proficiency of Voltage-gated Ion Channel Blockers in the Treatment of Inflammation-associated Diseases	6
Targeted Regulation of Intracellular Signal Transduction: A New Paradigm for Stimulation of Neurogenesis in Alzheimer's Disease	6
The Resurgence of H3N2 in India: Is it Life-threatening?	6
Beneficial Outcomes of Cancer Therapeutic Modalities Based on Targeting Apoptosis	6
Bidirectional Relations Between Anxiety, Depression, and Cancer: A Review	6
Beyond PD-1: Expanding the Landscape of Immune Checkpoint Targets in Cancer Therapy	5
Neuroinflammation in Alzheimer’s Disease: New Approaches	5
Endogenous Ligands of TLR4 in Microglia: Potential Targets for Related Neurological Diseases	5
Hybrid-Compounds Against Trypanosomiases	5
Molecular Glues for Undruggable Targets: Mechanisms, Clinical Applications, and AI-driven Design	5
Therapeutic Potential of Targeting Transforming Growth Factor-beta (TGF-β) and Programmed Death-ligand 1 (PD-L1) in Pancreatic Cancer	5
Long Non-coding RNA Therapeutics: Recent Advances and Challenges	5
The Therapeutic Potential of Targeting Hsp90-Cdc37 Interactions in Several Diseases	5
E2 Protein of Chikungunya Virus: A Narrative Review of Its Potential as a Therapeutic Target	5
Role of BMP-7 in Cardiovascular Diseases: From Molecular Mechanisms to Therapeutic Horizons	5
Meet the Section Editor	5
Cisplatin-Based Combination Therapy for Enhanced Cancer Treatment	5
Nanocarrier-based Drug Delivery Targeting GPCRs: Challenges, Clinical Translation, and Future Prospects for Precision Medicine	5
Promising New Targets for the Treatment of Infections Caused by Acinetobacter baumannii: A Review	5
Chronic Inflammation (A Silent Killer) – Molecular Mechanisms and Emerging Therapeutic Approaches	5
Phytoconstituents-Based Nanotherapeutic Approach for the Effective Management of Joint Inflammatory Condition: Arthritis	5
Two Decades Rituximab Therapy in Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis	5
NLRP3: A Promising Therapeutic Target for Inflammatory Bowel Disease	5
Gastrointestinal System: COVID-19 and Potential Mechanisms Associated with Coagulopathy	5
PTP1B Inhibitors for Type 2 Diabetes: From Natural Products, Synthetic Inhibitors, and Multi-Target Drug Design Strategies to Clinical Translation	5
Antiviral Potential of Traditional Unani Medicine with Special Emphasis on Dengue: A Review	5
A Review on the Recent Advancements and Artificial Intelligence in Tablet Technology	5
Comparative Analysis of Circular RNAs Expression and Function between Aortic and Intracranial Aneurysms	5
LncRNA HAGLROS: A Vital Oncogenic Propellant in Various Human Cancers	5
Quorum Sensing and its Inhibition in Pseudomonas aeruginosa: Molecular Targets and Mode of Action	4
Digoxin and Outcomes in Patients with Heart Failure and Preserved Ejection Fraction (HFpEF) Patients: A Systematic Review and Meta- Analysis	4
A Comprehensive Review on Liver Targeting: Emphasis on Nanotechnology- based Molecular Targets and Receptors Mediated Approaches	4
Exploring the Bioactive Components and Therapeutic Targets of Sanzi Decoction in Antihypertensive Treatment	4
Role of Vitamins in Therapeutic and Targeting Approaches for Prostate Cancer: An Overview	4
Current Situation on Diabetes Management: New Weapons Fighting the Disease in 2025	4
Barbatolic Acid Prevents Tau and Amylin Interaction and Stimulates the Growth of Acetylated Microtubules in Cell Culture	4
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis	4
Extracellular Vesicles from Stromal Vascular Fraction of Human Adipose Tissue in the Development of Non-antibiotic Therapy	4
Crucial Role of microRNAs as New Targets for Amelogenesis Disorders Detection	4
Nano Architect-Based Targeted Delivery Systems for Diabetic Nephropathy: A Review	4
Innovative Strategies and Advances in Drug Delivery Systems to Address Poor Solubility: A Comprehensive Review	4
A Comprehensive Review on Nanomedicine: Promising Approach for Treatment of Brain Tumor through Intranasal Administration	4
Deferoxamine Interference in Fibro-inflammation: Additional Action in Control of Obese Adipose Tissue Dysfunction	4
Deciphering the Function of New Therapeutic Targets and Prospective Biomarkers in the Management of Psoriasis	4
Cytokeratin 8 as a Novel Therapeutic Target in Type 2 Diabetes Mellitus: Suppression of Hepatic Glycogen Synthesis via IRS1/PI3K/Akt/GSK3β Signaling	4

Role of Artificial Intelligence in Nanomedicine and Organ-specific Therapy: An Updated Review	4
Strategies for Treatment of Thyroid Cancer	4
Antiobesity Drug Discovery Research: In vitro Models for Shortening the Drug Discovery Pipeline	4
Potential Target of CDK6 Signaling Pathway for Cancer Treatment	4
Comprehensive Analysis of Omicron Subvariants: EG.5 Rise, Vaccination Strategies, and Global Impact	4
Advances in Protein-Ligand Binding Affinity Prediction via Deep Learning: A Comprehensive Study of Datasets, Data Preprocessing Techniques, and Model Architectures	4
Recent Progress and Challenges in Clinical Translation of Nanomedicines in Diagnosis and Treatment of Lung Cancer	4
Redox Interactions in Chemo/Radiation Therapy-induced Lung Toxicity; Mechanisms and Therapy Perspectives	4
Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases	4
Structural Modifications in Chitosan Polymer Carries Synergistic Transfection in Drug Targeting	4
Toxic, Genotoxic and Teratogenic Effects of Ibuprofen and its Derivatives	4
The Clinical Safety and Efficacy of Targeted PD-L1 Therapy with Durvalumab in Solid Tumors	4
BRD4 Protein as a Target for Lung Cancer and Hematological Cancer Therapy: A Review	4
Investigational Agents Targeting SGLT1 and SGLT2 in the Treatment of Type 2 Diabetes Mellitus	3
An Insight into Hepatitis C Virus: In Search of Promising Drug Targets	3
Combinational Approaches Targeting Various Aspects Involved in Intestinal Barrier Dysfunction-Induced Anxiety	3
Novel Targets and Drug Delivery System in the Treatment of Postoperative Pain: Recent Studies and Clinical Advancement	3
Harnessing HIF-1α for Diabetic Wound Healing: From Molecular Insights to Therapeutic Strategies	3
Bee Venom and Cancer: A Mini-review Focusing on Melittin Antitumoral Effects	3
Therapeutic Potential of Scorpion Venom Proteins: Innovations in Cancer Treatment and Future Directions	3
In vitro Evaluation of Memantine and Nicotinamide Combination for Synergistic Cytotoxicity in U87MG Glioblastoma Cells	3
Targeting SERCA2 in Anti-Tumor Drug Discovery	3
SGK-1 Signalling Pathway is a Key Factor in Cell Survival in Ischemic Injury	3
Targeting the cGAS–STING Pathway in Gastrointestinal Cancers: Modulating Tumor-associated Inflammation for Therapeutic Effect	3
Biomarkers and Treatment Strategies for Breast Cancer Recurrence	3
Compounds Multi-targets against Neglected Diseases	3
Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana	3
Microtubules and Cell Division: Potential Pharmacological Targets in Cancer Therapy	3
Estimating the Survival Rate in Glioblastoma Multiforme Patients who Received a Peptide Vaccine: A Systematic Review and Meta-analysis	3
Clinical Deployment of Interpretable AI: Bridging Routine Clinical Tests and Proteomic Signatures for Preeclampsia Risk Stratification	3
Tebentafusp as a Promising Drug for the Treatment of Uveal Melanoma	3
In Vivo Models of Steroid-Induced Intraocular Hypertension	3
Recent Advances in the Prevention and Management of Monkeypox Viral Infection in Humans	3
Multi-target Agents in Complex Diseases: From Design Principles to Therapeutic Applications	3
The Potential of Mur Enzymes as Targets for Antimicrobial Drug Discovery	3
Advancing Amyloid Aggregation Research: A Focus on Innovative Therapies, Molecular Modeling and Nano-Delivery Systems in Alzheimer’s Disease	3
DRP1 Association in Inflammation and Metastasis: A Review	3
The Role of Host-Cellular Responses in COVID-19 Endothelial Dysfunction	3
Tissue Factor and COVID-19: An Update	3
Development of Novel Intravesical Formulation for Bladder Retention Targeting Bladder Disorders	3
A Review on Recent Development of Novel Heterocycles as Acetylcholinesterase Inhibitor for the Treatment of Alzheimer’s Disease	3
Fibrinolysis in COVID-19: Impact on Clot Lysis and Modulation of Inflammation	3