OOIR: Observatory of International Research

Papers

(The TQCC of Current Drug Metabolism is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery	70
Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic Receptor Blocker, 101BHG-D01, in Dogs and Rats	22
Metabolic Activation of Retrorsine may Disrupt Bile Acid Homeostasis in Mice through the Nrf2 Pathway	22
Novel Techniques and Models for Studying Drug Metabolism and Transport	20
Theoretical Evaluation of Oleocanthal Reactive Centers	18
In vitro and In vivo Drug Metabolism Analysis of BPI-460372 - A Covalent TEAD1/3/4 Inhibitor	17
Interactions of Betel Quid Constituents with Drug Disposition Pathways: An Overview	16
Potential Alteration of Rifampicin’s Bioavailability by Phyllanthus niruri Supplementation in Tuberculosis Therapy	16
Deciphering the Role of Nanoparticle-based Treatment for Parkinson’s Disease	16
Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme	15
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke	15
The Influences and Mechanisms of High-altitude Hypoxia Exposure on Drug Metabolism	15
Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Polygonatum sibiricum Polysaccharide on Type 2 Diabetes Mellitus Model Rats	15
Interactions Between Meropenem and Renal Drug Transporters	15
Tacrolimus, Cytochrome P450, Interactions with Food Variables in Organ Transplant Recipients; A Current and Comprehensive Review	14
ADMET Profiling in Drug Discovery and Development: Perspectives of In Silico, In Vitro and Integrated Approaches	14
Rapid Profiling of the Marker Components in Artemisia annua L. and their Metabolites in Rats Using an Improved Liquid Chromatography-tandem Highresolution Mass Spectrometry-based Technology	13
Meet the Section Editor	13
Regulation of Gut Microbiota by Herbal Medicines	13
Pharmacokinetics and Efficacy of Ceftriaxone in Staphylococcal Mastitis in Crossbred Cows Following Single Intravenous Administration	13
Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review	12
Suppression of Melanoma Growth in a Murine Tumour Model Using Orthosiphon stamineus Benth. Extract Loaded in Ethanolic Phospholipid Vesicles (Spherosome)	12
Urine Metabolites as a Predictor of Warfarin Response Based on INR in Atrial Fibrillation	12
Role of Cytochrome P450 3A4 in Cancer Drug Resistance: Challenges and Opportunities	12
Influence of Zhuanggu Guanjie Pill on Seven Cytochrome P450 Enzymes Based on Probe Cocktail and Pharmacokinetics Approaches	11

The Function of Multidrug Resistance-associated Protein 3 in the Transport of Bile Acids under Normal Physiological and Lithocholic Acid-induced Cholestasis Conditions	11
Inhibition of Glycyrrhiza Polysaccharide on Human Cytochrome P450 46A1 in vitro and in vivo: Implications in Treating Neurological Diseases	11
Meet the Associate Editor	10
Nucleic Acid Nanomaterials: Biostability and Applications	10
Absorption, Metabolism, Distribution, and Excretion of Letermovir	10
Meet the Associate Editorial Board Member	10
Comparative Analysis of Machine Learning Algorithms Evaluating the Single Nucleotide Polymorphisms of Metabolizing Enzymes with Clinical Outcomes Following Intravenous Paracetamol in Preterm Neonates	9
Meet the Editorial Board Member	9
The Impacts and Changes Related to the Cancer Drug Resistance Mechanism	9
WITHDRAWN: Pharmacokinetic Drug Interactions of Piperine: A Review of Pre-clinical and Clinical Studies	9
Circadian Timekeeping in Anticancer Therapeutics: An Emerging Vista of Chronopharmacology Research	9
Evaluation of Supervised Machine Learning Algorithms and Computational Structural Validation of Single Nucleotide Polymorphisms Related to Acute Liver Injury with Paracetamol	8
Pharmacokinetic Interaction between Imatinib and Tacrolimus in Rats	8
In vitro Measurement and In vivo Prediction of Time-Dependent Inhibitory Effects of Three Tyrosine Kinase Inhibitors on CYP3A Activity	8
Meet the Editorial Board Member	8
The Effect of Coenzyme Q10 as a Part of Standard Therapy on Plasma Concentrations of Ubiquinol, Ubiquinone, Total CoQ10 and its Redox State in Patients with Ischemic Heart Disease	8
Relevance of ABC Transporters in Drug Development	8
Meet the Associate Editor	8
Nanotechnology Driven Approaches for the Management of Parkinson’s Disease: Current Status and Future Perspectives	8
Meet the Editorial Board Member	7
Genetic Testing is Superior Over Endogenous Pharmacometabolomic Markers to Predict Safety of Haloperidol in Patients with Alcohol-induced Psychotic Disorder	7
Association of UGT1A Gene Polymorphisms with BKV Infection in Renal Transplantation Recipients	7
The Metabolic Pathways and Products of Ten Aconitum Alkaloids in Sanwujiao Pills from Eight Organs of Mice by UHPLC-Q-TOF-MS/MS	7
Metabolism is not a Major Contributor to the Toxicity of Piperaquine, a Long-acting Antimalarial Agent in Artemisinin-based Combination Therapy	7
Rapid and Comprehensive Identification of Vincosamide Metabolites in vitro and in vivo in Rats by Ultra-High Performance Liquid Chromatography-Quadrupole- Exactive Orbitrap-High Resolution Mass Spectr	7
Investigating the Metabolic Mechanisms of Butaselen, An Ebselen Analog	7
Comparative Analysis of Pharmacokinetics and Metabolites of Three Main Terpenoids before and after Compatibility of Frankincense and Myrrh in Rats by UHPLC-MS	6
Influence of CYP2C9 Polymorphisms on Plasma Concentration of Warfarin and 7-Hydroxy Warfarin in South Indian Patients	6
Effects of Fasting andPhoenix dactyliferaon the Expression of Major Drug- Metabolizing Enzymes in the Mouse Livers	6
Nanostructured Therapeutic Systems of PUFAs for the Treatment of Glioblastoma Multiforme	6
Corrigendum To: Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates	6
Comparative in Vitro Metabolic Profile Study of Five Cathinone Derivatives	6
Drug Metabolizing Enzymes: An Exclusive Guide into Latest Research in Pharmaco-genetic Dynamics in Arab Countries	6
In vivo Metabolism of Nifurtimox and the Drug-Drug Interaction Potential Including its Major Metabolites	6
Worldwide Prevalence of Polypharmacy: A Systematic Review	6
Meet the Editorial Board Member	6
Overexpression of MRP3 in HeLa-UGT1A9 Cells Enhances Glucuronidation Capability of the Cells	6
Effect of Dexketoprofen on the Disposition Kinetics of Moxifloxacin in Plasma and Lung in Male and Female Rats	6
Hydrogen Peroxide Induces Ethanol-inducible CYP2E1 via the NF-kB-classical Pathway: CYP2E1 mRNA Levels are not High in Alcoholic Hepatitis	5
Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates	5
The Application of Nucleic Acid Nanomaterials in the Treatment of Mitochondrial Dysfunction	5
The Impact of Certain Pharmacogenetic Differences on the Metabolism of Antiretroviral Drugs Used in A Black South African Population	5
Pharmacokinetic/Pharmacodynamic Study of Salt-Processed Product of Cuscutae Semen with Hepatoprotective Effects	5
Effects of CPY3A5 Genetic Polymorphisms on the Pharmacokinetics of Extendedrelease and Immediate-release Tacrolimus Formulations in Renal Transplant Recipients: A Systematic Review and Meta-analysis	5
Pharmacokinetics and Tissue Distribution of Isovitexin-2''-O-β-D-glucopyranoside (IVG) in Sprague-Dawley Rats	5
Lingguizhugan Decoction Improved Obesity by Modulating the Gut Microbiota and its Metabolites in Mice	5
UPLC-ESI-Q-TOF/MS Based Metabolic Profiling of Protosappanin B in Rat Plasma, Bile, Feces, Urine and Intestinal Bacteria Samples	5
Gut Microbiota as the Potential Mechanism to Mediate Drug Metabolism Under High-altitude Hypoxia	5
Study on the Relationship between Rivaroxaban and Factor Xa Activity in Blood Based on HPLC-MS/MS	5
Orchestration of Obesolytic Activity of Microbiome: Metabiotics at Centre Stage	5

Meet the Co-Editor	5
Research Progress of Epigenetic Modification on the Regulation of Transporters Under Hypoxia	5
A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look	5
Chloro-s-triazines-toxicokinetic, Toxicodynamic, Human Exposure, and Regulatory Considerations	5
Additive Manufacturing and Printing Approaches for the Development of Pharmaceutical Dosage Forms with Improved Biopharmaceutical Attributes	5
Machine Learning in Drug Metabolism Study	4
Effect of Salbutamol on the Disposition Kinetics of Levofloxacin in the Plasma and Lung of Rats	4
DNA-based Nanomaterials in the Immunotherapy	4
Exploring Drug-Drug Interactions between Losartan and Carbamazepine: A Pharmacokinetic and Pharmacodynamic Study	4
Unraveling the Role of COMT Polymorphism in Dopamine-Mediated Vasopressor Effects: An Observational Cross-Sectional Study	4
Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update	4
Effect of Wuzhi Capsule (WZC) on the Pharmacokinetics of Tacrolimus in Renal Transplantation Recipients	4
A Novel Nanoformulation of Ellagic Acid is Promising in Restoring Oxidative Homeostasis in Rat Brains with Alzheimer’s Disease	4
Comprehensive Identification of Astilbin Metabolites in Rats Based on Multiple Metabolite Templates Combined with UHPLC-Q-Exactive Mass Spectrometry	4
Cabozantinib Carries the Risk of Drug-Drug Interactions via Inhibition of UDPglucuronosyltransferase (UGT) 1A9	4
Comprehensive Metabolism Study of Tangeretin in Rat Plasma, Urine and Faeces Using Ultra-High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole- Orbitrap High-Resolution Accurate Mass Spe	4
Meet the Co-Editor	4
Meet the Editorial Board Member	4
Nutritional Therapy Strategies Targeting Tumor Energy Metabolism	4
Metabolite Identification in the Preclinical and Clinical Phase of Drug Development	4
Quality by Design Approach for the Development of Cariprazine Hydrochloride Loaded Lipid-Based Formulation for Brain Delivery via Intranasal Route	4
miRNAs in SARS-CoV-2 Infection: An Update	4
Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction	4
Meet the Editorial Board Member	4
Effects of CYP2B6 Genetic Variants on the Propofol Dose and Response among Jordanian Arabic Patients Undergoing General Anesthesia	4
Impact of Drug Metabolism/Pharmacokinetics and its Relevance Considering Traditional Medicine-based Anti-COVID-19 Drug Research	4
Umbelliferone Enhances Immune Function in Cyclophosphamide-Induced Immunosuppressed Mice via Histidine and Purine Metabolism Regulation	4
In Silico Tools to Thaw the Complexity of the Data: Revolutionizing Drug Research in Drug Metabolism, Pharmacokinetics and Toxicity Prediction	4
Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model	4
An Efficient Integrated Strategy for Comprehensive Metabolite Profiling of Sakurasosaponin from Aegiceras corniculatum in Rats	4
Meet the Regional Editor	4
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines	4
Various Aspects of Fasting on the Biodistribution of Radiopharmaceuticals	4
Evaluation of Alterations in DNA Methylation of CYP3A4 Gene Upstream Regulatory Elements in Gastric Cancer and in Response to Diazinon Treatment	4
The Development of a Physiologically Based Pharmacokinetic (PBPK) Model of Andrographolide in Mice and Scaling it up to Rats, Dogs, and Humans	4