OOIR: Observatory of International Research

Papers

(The TQCC of Current Drug Metabolism is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
ADMET Profiling in Drug Discovery and Development: Perspectives of In Silico, In Vitro and Integrated Approaches	51
Salidroside - Can it be a Multifunctional Drug?	42
Nanostructured Lipid Carriers (NLCs): Nose-to-Brain Delivery and Theranostic Application	32
Tumor Angiogenesis and VEGFR-2: Mechanism, Pathways and Current Biological Therapeutic Interventions	29
Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections	28
Polymeric Nanoparticles for Brain Drug Delivery - A Review	27
Dietary Baicalin Zinc Supplementation Alleviates Oxidative Stress and Enhances Nutrition Absorption in Deoxynivalenol Challenged Pigs	26
Nano Phytomedicine Based Delivery System for CNS Disease	24
The Current State of Potential Therapeutic Modalities for Glioblastoma Multiforme: A Clinical Review	23
Biosurfactants as a Novel Additive in Pharmaceutical Formulations: Current Trends and Future Implications	21
A Review: Effects of Macrolides on CYP450 Enzymes	20
Metabolite Identification in the Preclinical and Clinical Phase of Drug Development	19
Chloro-s-triazines-toxicokinetic, Toxicodynamic, Human Exposure, and Regulatory Considerations	19
Natural Compounds as Source of Aldose Reductase (AR) Inhibitors for the Treatment of Diabetic Complications: A Mini Review	18
Metabolism and Mechanism of Human Cytochrome P450 Enzyme 1A2	18
Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review	17
Topical Capsaicin for the Treatment of Neuropathic Pain	16
HMG-CoA Reductase Inhibitors (Statins) and their Drug Interactions Involving CYP Enzymes, P-glycoprotein and OATP Transporters-An Overview	15
Metabolism and Pharmacological Mechanisms of Active Ingredients in Erigeron breviscapus	15
A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview	15
Murburn Precepts for Cytochrome P450 Mediated Drug/Xenobiotic Metabolism and Homeostasis	15
Analysis of the Potential Association of Drug-Metabolizing Enzymes CYP2C93 and CYP2C193 Gene Variations With Type 2 Diabetes: A Case-Control Study	14
Physiologically-based Pharmacokinetic (PBPK) Modelling of Transporter Mediated Drug Absorption, Clearance and Drug-drug Interactions	13
Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters	13
Gold Nanoparticles; Potential Nanotheranostic Agent in Breast Cancer: A Comprehensive Review with Systematic Search Strategy	12

Medicinal Plants and Natural Products: More Effective and Safer Pharmacological Treatment for the Management of Obesity	12
The Role of Metabolism in Toxicity of Polycyclic Aromatic Hydrocarbons and their Non-genotoxic Modes of Action	12
Recent Advances in Nanotechnology-Based Targeted Therapeutics for Breast Cancer Management	12
Application of Advanced Technologies in Natural Product Research: A Review with Special Emphasis on ADMET Profiling	12
Applications of Machine Learning in Drug Target Discovery	11
Comparison of Bromhexine and its Active Metabolite - Ambroxol as Potential Analgesics Reducing Oxaliplatin-induced Neuropathic Pain - Pharmacodynamic and Molecular Docking Studies	11
Inhibition of Efflux Pumps by Monoterpene (α-pinene) and Impact on Staphylococcus aureus Resistance to Tetracycline and Erythromycin	11
Recent Advances in Biotransformation by Cunninghamella Species	11
Secondary Metabolites in the Treatment of Diabetes Mellitus: A Paradigm Shift	11
Mechanism of the Intestinal Absorption of Six Flavonoids from Zizyphi Spinosi Semen Across Caco-2 Cell Monolayer Model	10
Development and Validation of a Sensitive UPLC-Q-TOF-MS/MS for the Measurement of Nine Components in Rat Plasma and Tissues and its Application to Pharmacokinetics and Tissue Distribution Studies with	10
The Influence of Different Disease States on Rituximab Pharmacokinetics	10
Nanocrystals: An Approachable Delivery System for Anticancer Therapeutics	10
Absorption, Distribution, Metabolism, and Excretion of Aprocitentan, a Dual Endothelin Receptor Antagonist, in Humans	10
Research Progress of Herbal Medicines on Drug Metabolizing Enzymes: Consideration Based on Toxicology	10
Protective Effects of Grape Seed Proanthocyanidin Extract in Preventing DSS Induced Ulcerative Colitis Based on Pharmacodynamic, Pharmacokinetic and Tissue Distribution	9
Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery	9
Deciphering the Role of Nanoparticle-based Treatment for Parkinson’s Disease	9
Current Treatment Options for HCC: From Pharmacokinetics to Efficacy and Adverse Events in Liver Cirrhosis	9
Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update	9
Thymoquinone Lipid Nanoparticles Cut the Gordian Knots of Depression via Neuroprotective BDNF and Downregulation of Neuro-inflammatory NF-κB, IL-6, and TNF-α in LPS Treated Rats	9
An Overview of Dietary Supplements on Obesity and Type 2 Diabetes: Efficacy and Mechanisms	9
Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases and their Metabolic Profiling: Part 1	9
Recent Advances in Nanotechnology: A Novel Therapeutic System for the Treatment of Alzheimer’s Disease	9
Cytochromes P450: Role in Carcinogenesis and Relevance to Cancers	9
A Decade’s Review of miRNA: A Center of Transcriptional Regulation of Drugmetabolizing Enzymes and Transporters under Hypoxia	8
Effective Cancer Management: Inimitable Role of Phytochemical Based Nano- Formulations	8
Isolation, Docking and In Silico ADME-T Studies of Acacianol: Novel Antibacterial Isoflavone Analogue Isolated from Acacia leucophloea Bark	8
Pain Allaying Epalrestat-Loaded Lipid Nanoformulation for the Diabetic Neuropathic Pain Interventions: Design, Development, and Animal Study	8
Receptor-Mediated Targeting in Breast Cancer through Solid Lipid Nanoparticles and Its Mechanism	8
Withania somnifera in Neurological Disorders: Ethnopharmacological Evidence, Mechanism of Action and its Progress in Delivery Systems	8
The Metabolism and Pharmacokinetics of Rhein and Aurantio-Obtusin	8
Interactions Between Meropenem and Renal Drug Transporters	8
Pharmacokinetic Study of Vadadustat and High-Resolution Mass Spectrometric Characterization of its Novel Metabolites in Equines for the Purpose of Doping Control	8
An Update on the Recent Advances in Cubosome: A Novel Drug Delivery System	8
Role of Glucose Transporters in Drug Membrane Transport	8
Hepatoprotective Role of Berberine on Doxorubicin Induced Hepatotoxicity - Involvement of Cyp	7
Simultaneous Method Development and Validation of Anastrozole Along with Piperine: Degradation Studies and Degradants Characterization Using LC-QTOF-ESI-MS Along with In-silico ADMET Prediction	7
Structure of the Blood Brain Barrier and its Role in the Transporters for the Movement of Substrates across the Barriers	7
Role of Genetic Polymorphisms of Cytochrome P450 2C19 in Pantoprazole Metabolism and Pantoprazole-based Helicobacter pylori Eradication Regimens	7
Relevance of ABC Transporters in Drug Development	7
Review of the Clinical Pharmacokinetics, Efficacy and Safety of Pembrolizumab	7
Gut Microbiota as the Potential Mechanism to Mediate Drug Metabolism Under High-altitude Hypoxia	7
Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases and their Metabolic Profiling - Part 3	7
Absorption, Metabolism, Distribution, and Excretion of Letermovir	7
The Genetic Polymorphism of CYP3A4 rs2242480 is Associated with Sirolimus Trough Concentrations Among Adult Renal Transplant Recipients	7
The Influences and Mechanisms of High-altitude Hypoxia Exposure on Drug Metabolism	7
Rapid Profiling and Identification of Vitexin Metabolites in Rat Urine, Plasma and Faeces after Oral Administration Using a UHPLC-Q-Exactive Orbitrap Mass Spectrometer Coupled with Multiple Data-minin	6
Impact of Pharmacogenetic Determinants of Tacrolimus and Mycophenolate on Adverse Events in Renal Transplant Patients	6
Tumor-targeted Drug Delivery by Nanocomposites	6

Risk Assessment of Veterinary Drug Residues in Meat Products	6
Bibliometric Analysis of Current Drug Metabolism: The Twentieth Anniversary from 2000-2019	6
Antibiotics as Inhibitor of Glutathione S-transferase: Biological Evaluation and Molecular Structure Studies	6
Study on the Plasma Protein Binding Rate and Compatibility Regularity of the Constituents Migrating to Blood of Simiao Yong’an Decoction	6
Recent Progress on Mass Spectrum Based Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Traditional Chinese Medicine	6
The Role of Biotransformation in the Activity of Endocrine Disruptors	6
Approaches to Address PK-PD Challenges of Conventional Liposome Formulation with Special Reference to Cancer, Alzheimer's, Diabetes, and Glaucoma: An Update on Modified Liposomal Drug Delivery System	6
Regulatory Effects of N-3 PUFAs on Pancreatic β-cells and Insulin-sensitive Tissues	6
A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look	6
Effects of Fasting andPhoenix dactyliferaon the Expression of Major Drug- Metabolizing Enzymes in the Mouse Livers	5
In vitro Metabolism of Humantenine in Liver Microsomes from Human, Pig, Goat and Rat	5
Recent Advances on Antioxidant Identification Based on Machine Learning Methods	5
A Novel Nanoformulation of Ellagic Acid is Promising in Restoring Oxidative Homeostasis in Rat Brains with Alzheimer’s Disease	5
Annonaceae Family Alkaloids as Agents Against Leishmaniasis: A Review and Molecular Docking Evaluation	5
Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction	5
Role of Natural Products in the Treatment of Obesity: Nanotechnological Perspectives	5
Advances in Hybrid Vesicular-based Drug Delivery Systems: Improved Biocompatibility, Targeting, Therapeutic Efficacy and Pharmacokinetics of Anticancer Drugs	5
Impact of Drug Metabolism/Pharmacokinetics and its Relevance Considering Traditional Medicine-based Anti-COVID-19 Drug Research	5
Vitamin D Metabolism Gene Polymorphisms and Their Associated Disorders: A Literature Review	5
Recent Patents, Regulatory Issues, and Toxicity of Nanoparticles in Neuronal Disorders	5
Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement	5
New Horizons in the Treatment of Neurological Disorders with Tailorable Gold Nanoparticles	5
Elevated Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Predict Drug-Induced Acute Kidney Injury	5
Pharmacokinetics-based Chronotherapy	5
Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic	5
Molecular Modeling Studies on Cytochrome P450-mediated Drug Metabolism	5
The Current Application of LC-MS/MS in Pharmacokinetics of Traditional Chinese Medicines (Recent Three Years): A Systematic Review	5
A Comprehensive Review of the Pharmacologic Perspective on Loop Diuretic Drug Interactions with Therapeutically Used Drugs	5
Predicted Contributions of Flavin-containing Monooxygenases to the N-oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants	5
Factors Influencing ADME Properties of Therapeutic Antisense Oligonucleotides: Physicochemical Characteristics and Beyond	5
An Overview of the Neuropharmacological Potential of Thymoquinone and its Targeted Delivery Prospects for CNS Disorder	5
Aceclofenac-Loaded Microspheres Prepared by Vesicular Ionotropic Gelation to Minimize Drug-induced Gastric Ulcers in Rats	5