Current Drug Metabolism

Papers
(The TQCC of Current Drug Metabolism is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)
ArticleCitations
2020 FDA Drug-drug Interaction Guidance: A Comparison Analysis and Action Plan by Pharmaceutical Industrial Scientists71
ADMET Profiling in Drug Discovery and Development: Perspectives of In Silico, In Vitro and Integrated Approaches36
Salidroside - Can it be a Multifunctional Drug?30
Tumor Angiogenesis and VEGFR-2: Mechanism, Pathways and Current Biological Therapeutic Interventions27
Polymeric Nanoparticles for Brain Drug Delivery - A Review27
Chemical Metabolism of Xenobiotics by Gut Microbiota24
Nanostructured Lipid Carriers (NLCs): Nose-to-Brain Delivery and Theranostic Application24
Dietary Baicalin Zinc Supplementation Alleviates Oxidative Stress and Enhances Nutrition Absorption in Deoxynivalenol Challenged Pigs24
Genistein: Its Role in Breast Cancer Growth and Metastasis23
The Current State of Potential Therapeutic Modalities for Glioblastoma Multiforme: A Clinical Review23
Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections21
Biosurfactants as a Novel Additive in Pharmaceutical Formulations: Current Trends and Future Implications18
Nano Phytomedicine Based Delivery System for CNS Disease18
Exosome-based Tumor Therapy: Opportunities and Challenges17
Therapeutics and Research Related to Glioblastoma: Advancements and Future Targets16
Murburn Precepts for Cytochrome P450 Mediated Drug/Xenobiotic Metabolism and Homeostasis15
Metabolism and Mechanism of Human Cytochrome P450 Enzyme 1A215
A Review: Effects of Macrolides on CYP450 Enzymes15
Topical Capsaicin for the Treatment of Neuropathic Pain15
Tubulin Proteins in Cancer Resistance: A Review15
Clinical Pharmacokinetics of Propranolol Hydrochloride: A Review14
Natural Compounds as Source of Aldose Reductase (AR) Inhibitors for the Treatment of Diabetic Complications: A Mini Review14
Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review14
Metabolite Identification in the Preclinical and Clinical Phase of Drug Development14
Chloro-s-triazines-toxicokinetic, Toxicodynamic, Human Exposure, and Regulatory Considerations14
Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters13
Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review13
Stem Cells in Tumour Microenvironment Aid in Prolonged Survival Rate of Cancer Cells and Developed Drug Resistance: Major Challenge in Osteosarcoma Treatment12
HMG-CoA Reductase Inhibitors (Statins) and their Drug Interactions Involving CYP Enzymes, P-glycoprotein and OATP Transporters-An Overview12
Analysis of the Potential Association of Drug-Metabolizing Enzymes CYP2C9*3 and CYP2C19*3 Gene Variations With Type 2 Diabetes: A Case-Control Study11
Metabolism and Pharmacological Mechanisms of Active Ingredients in Erigeron breviscapus11
Gold Nanoparticles; Potential Nanotheranostic Agent in Breast Cancer: A Comprehensive Review with Systematic Search Strategy11
Inhibition of Efflux Pumps by Monoterpene (α-pinene) and Impact on Staphylococcus aureus Resistance to Tetracycline and Erythromycin11
Medicinal Plants and Natural Products: More Effective and Safer Pharmacological Treatment for the Management of Obesity10
Application of Advanced Technologies in Natural Product Research: A Review with Special Emphasis on ADMET Profiling10
Talin: A Potential Drug Target for Cancer Therapy10
Recent Advances in Biotransformation by Cunninghamella Species10
The Potential Role of Serum Exosomes in Preeclampsia10
Research Progress of Herbal Medicines on Drug Metabolizing Enzymes: Consideration Based on Toxicology10
Prognostic Role of Hedgehog-GLI1 Signaling Pathway in Aggressive and Metastatic Breast Cancers10
Effect of Nigella sativa and Fenugreek on the Pharmacokinetics and Pharmacodynamics of Amlodipine in Hypertensive Rats10
Comparison of Bromhexine and its Active Metabolite - Ambroxol as Potential Analgesics Reducing Oxaliplatin-induced Neuropathic Pain - Pharmacodynamic and Molecular Docking Studies10
Recent Advances in Nanotechnology-Based Targeted Therapeutics for Breast Cancer Management9
A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview9
Development and Validation of a Sensitive UPLC-Q-TOF-MS/MS for the Measurement of Nine Components in Rat Plasma and Tissues and its Application to Pharmacokinetics and Tissue Distribution Studies with9
Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases and their Metabolic Profiling: Part 19
Mechanism of the Intestinal Absorption of Six Flavonoids from Zizyphi Spinosi Semen Across Caco-2 Cell Monolayer Model9
Decoding Novel Mechanisms and Emerging Therapeutic Strategies in Breast Cancer Resistance9
Absorption, Distribution, Metabolism, and Excretion of Aprocitentan, a Dual Endothelin Receptor Antagonist, in Humans9
Further Considerations Towards an Effective and Efficient Oncology Drug Discovery DMPK Strategy9
An Overview of Dietary Supplements on Obesity and Type 2 Diabetes: Efficacy and Mechanisms9
Nanocrystals: An Approachable Delivery System for Anticancer Therapeutics8
Deciphering the Role of Nanoparticle-based Treatment for Parkinson’s Disease8
Applications of Machine Learning in Drug Target Discovery8
An Update on the Recent Advances in Cubosome: A Novel Drug Delivery System8
Thymoquinone Lipid Nanoparticles Cut the Gordian Knots of Depression via Neuroprotective BDNF and Downregulation of Neuro-inflammatory NF-κB, IL-6, and TNF-α in LPS Treated Rats8
The Influence of Different Disease States on Rituximab Pharmacokinetics8
Physiologically-based Pharmacokinetic (PBPK) Modelling of Transporter Mediated Drug Absorption, Clearance and Drug-drug Interactions8
Naphthalene Toxicity in Clinical Practice8
Pharmacogenetic Evaluation of Metformin and Sulphonylurea Response in Mexican Mestizos with Type 2 Diabetes8
Interactions Between Meropenem and Renal Drug Transporters8
The Role of Metabolism in Toxicity of Polycyclic Aromatic Hydrocarbons and their Non-genotoxic Modes of Action8
Protective Effects of Grape Seed Proanthocyanidin Extract in Preventing DSS Induced Ulcerative Colitis Based on Pharmacodynamic, Pharmacokinetic and Tissue Distribution8
Isolation, Docking and In Silico ADME-T Studies of Acacianol: Novel Antibacterial Isoflavone Analogue Isolated from Acacia leucophloea Bark8
The Metabolism and Pharmacokinetics of Rhein and Aurantio-Obtusin8
Effective Cancer Management: Inimitable Role of Phytochemical Based Nano- Formulations7
Tumor-targeted Drug Delivery by Nanocomposites7
A Decade’s Review of miRNA: A Center of Transcriptional Regulation of Drugmetabolizing Enzymes and Transporters under Hypoxia7
Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases and their Metabolic Profiling - Part 37
Changes of Transporters and Drug-metabolizing Enzymes in Nephrotic Syndrome7
Secondary Metabolites in the Treatment of Diabetes Mellitus: A Paradigm Shift7
Current Treatment Options for HCC: From Pharmacokinetics to Efficacy and Adverse Events in Liver Cirrhosis7
Role of Exosomes in the Exchange of Spermatozoa after Leaving the Seminiferous Tubule: A Review7
Role of Genetic Polymorphisms of Cytochrome P450 2C19 in Pantoprazole Metabolism and Pantoprazole-based Helicobacter pylori Eradication Regimens7
Bibliometric Analysis of Current Drug Metabolism: The Twentieth Anniversary from 2000-20196
Recent Advances in Nanotechnology: A Novel Therapeutic System for the Treatment of Alzheimer’s Disease6
Versatile and Valuable Utilization of Amidohydrolase L-glutaminase in Pharma and Food industries: A Review6
Study on the Plasma Protein Binding Rate and Compatibility Regularity of the Constituents Migrating to Blood of Simiao Yong’an Decoction6
Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-glycoprotein6
Hepatoprotective Role of Berberine on Doxorubicin Induced Hepatotoxicity - Involvement of Cyp6
Preclinical Study of the Pharmacokinetics of p75ECD-Fc, a Novel Human Recombinant Protein for Treatment of Alzheimer’s Disease, in Sprague Dawley Rats6
Absorption, Metabolism, Distribution, and Excretion of Letermovir6
The Genetic Polymorphism of CYP3A4 rs2242480 is Associated with Sirolimus Trough Concentrations Among Adult Renal Transplant Recipients6
Clinical Application of Thiopurine Pharmacogenomics in Pediatrics6
Relevance of ABC Transporters in Drug Development6
Review of the Clinical Pharmacokinetics, Efficacy and Safety of Pembrolizumab6
Antibiotics as Inhibitor of Glutathione S-transferase: Biological Evaluation and Molecular Structure Studies6
Pain Allaying Epalrestat-Loaded Lipid Nanoformulation for the Diabetic Neuropathic Pain Interventions: Design, Development, and Animal Study6
Impact of Drug Metabolism/Pharmacokinetics and its Relevance Considering Traditional Medicine-based Anti-COVID-19 Drug Research5
Modulation of the Drug Resistance by Platonia insignis Mart. Extract, Ethyl Acetate Fraction and Morelloflavone/Volkensiflavone (Biflavonoids) in Staphylococcus aureus Strains Overexpressing Efflux Pu5
Recent Advances on Antioxidant Identification Based on Machine Learning Methods5
Predicted Contributions of Flavin-containing Monooxygenases to the N-oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants5
Curcumin Nanoemulsions Stabilized with Modified Phosphatidylcholine on Skin Carcinogenesis Protocol5
Risk Assessment of Veterinary Drug Residues in Meat Products5
Molecular Modeling Studies on Cytochrome P450-mediated Drug Metabolism5
Receptor-Mediated Targeting in Breast Cancer through Solid Lipid Nanoparticles and Its Mechanism5
Recent Patents, Regulatory Issues, and Toxicity of Nanoparticles in Neuronal Disorders5
Role of Glucose Transporters in Drug Membrane Transport5
Cytochromes P450: Role in Carcinogenesis and Relevance to Cancers5
Pharmacokinetic Study of Vadadustat and High-Resolution Mass Spectrometric Characterization of its Novel Metabolites in Equines for the Purpose of Doping Control5
Rapid Profiling and Identification of Vitexin Metabolites in Rat Urine, Plasma and Faeces after Oral Administration Using a UHPLC-Q-Exactive Orbitrap Mass Spectrometer Coupled with Multiple Data-minin5
A Novel Nanoformulation of Ellagic Acid is Promising in Restoring Oxidative Homeostasis in Rat Brains with Alzheimer’s Disease5
Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery5
A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look5
Current Advances in Drug Delivery Systems for Capsule Endoscopy4
Clinical Impact of Co-medication of Levetiracetam and Clobazam with Proton Pump Inhibitors: A Drug Interaction Study4
Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases & their Metabolic Profiling-Part 24
Chemistry and Antioxidant Potential of Phytoconstituents from Aegle Marmelos Fruit-Shell4
JAK Inhibition as a Therapeutic Strategy for Inflammatory Bowel Disease4
CYP2C and CYP2B Mediated Metabolic Activation of Retrorsine in Cyp3a Knockout Mice4
Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update4
Approaches to Address PK-PD Challenges of Conventional Liposome Formulation with Special Reference to Cancer, Alzheimer's, Diabetes, and Glaucoma: An Update on Modified Liposomal Drug Delivery System4
Simultaneous Method Development and Validation of Anastrozole Along with Piperine: Degradation Studies and Degradants Characterization Using LC-QTOF-ESI-MS Along with In-silico ADMET Prediction4
Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction4
Structure of the Blood Brain Barrier and its Role in the Transporters for the Movement of Substrates across the Barriers4
Advances in Hybrid Vesicular-based Drug Delivery Systems: Improved Biocompatibility, Targeting, Therapeutic Efficacy and Pharmacokinetics of Anticancer Drugs4
Current Trends for Rationalizing Brain Targeting Nanoparticles in Neurological Disorders (Part-I)4
Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic4
The Influence of Kidneys Ion Transport Inhibitors on the Pharmacokinetic and Tumor Uptake Behaviors of a HER2-targeted Small Size Radiolabeled Peptide4
Modulation of Drug Resistance by Limonene: Inhibition of Efflux Pumps in Staphylococcus aureus Strains RN-4220 and IS-584
Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement4
New Horizons in the Treatment of Neurological Disorders with Tailorable Gold Nanoparticles4
Role of Natural Products in the Treatment of Obesity: Nanotechnological Perspectives4
An Overview of the Neuropharmacological Potential of Thymoquinone and its Targeted Delivery Prospects for CNS Disorder4
Targeting the Pathological Hallmarks of Alzheimer’s Disease Through Nanovesicleaided Drug Delivery Approach4
Effect of Green Tea and (-)-Epigallocatechin Gallate on the Pharmacokinetics of Rosuvastatin4
Gut Microbiota as the Potential Mechanism to Mediate Drug Metabolism Under High-altitude Hypoxia4
In Silico ADMET Evaluation of Natural DPP-IV Inhibitors for Rational Drug Design against Diabetes4
Drug-induced Bile Duct Injury - A Short Review4
The Role of Biotransformation in the Activity of Endocrine Disruptors4
The Current Application of LC-MS/MS in Pharmacokinetics of Traditional Chinese Medicines (Recent Three Years): A Systematic Review4
Withania somnifera in Neurological Disorders: Ethnopharmacological Evidence, Mechanism of Action and its Progress in Delivery Systems4
Annonaceae Family Alkaloids as Agents Against Leishmaniasis: A Review and Molecular Docking Evaluation4
Regulatory Effects of N-3 PUFAs on Pancreatic β-cells and Insulin-sensitive Tissues4
Suppression of Melanoma Growth in a Murine Tumour Model Using Orthosiphon stamineus Benth. Extract Loaded in Ethanolic Phospholipid Vesicles (Spherosome)4
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