OOIR: Observatory of International Research

Papers

(The TQCC of Current Drug Metabolism is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Novel Techniques and Models for Studying Drug Metabolism and Transport	46
Potential Alteration of Rifampicin’s Bioavailability by Phyllanthus niruri Supplementation in Tuberculosis Therapy	44
Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery	37
Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme	23
Theoretical Evaluation of Oleocanthal Reactive Centers	22
HFD-induced Alterations in Renal Tubular Oatp4c1-P-gp Transport Systems in Mice: Impact on Digoxin Renal Excretion and Gadolinium-Enhanced Radiological Manifestations	22
Interactions of Betel Quid Constituents with Drug Disposition Pathways: An Overview	19
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke	18
Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Polygonatum sibiricum Polysaccharide on Type 2 Diabetes Mellitus Model Rats	17
In vitro and In vivo Drug Metabolism Analysis of BPI-460372 - A Covalent TEAD1/3/4 Inhibitor	17
The Influences and Mechanisms of High-altitude Hypoxia Exposure on Drug Metabolism	17
Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic Receptor Blocker, 101BHG-D01, in Dogs and Rats	17
Targeting Metabolic Dysregulation in Alzheimer’s Disease: A Potential Therapeutic Strategy	16
Network Pharmacology and Metabolomics to Uncover the Multi-Target Anti-Non-Small Cell Lung Cancer Mechanism of Baicalin Mediated by Purine Metabolism	14
Meet the Section Editor	14
Meet the Associate Editorial Board Member	12
Regulation of Gut Microbiota by Herbal Medicines	12
Meet the Associate Editor	12
Tacrolimus, Cytochrome P450, Interactions with Food Variables in Organ Transplant Recipients; A Current and Comprehensive Review	12
WITHDRAWN: Pharmacokinetic Drug Interactions of Piperine: A Review of Pre-clinical and Clinical Studies	11
Acknowledgements to Reviewers	11
Role of Cytochrome P450 3A4 in Cancer Drug Resistance: Challenges and Opportunities	11
Influence of Zhuanggu Guanjie Pill on Seven Cytochrome P450 Enzymes Based on Probe Cocktail and Pharmacokinetics Approaches	11
Nucleic Acid Nanomaterials: Biostability and Applications	11
Comparative Analysis of Machine Learning Algorithms Evaluating the Single Nucleotide Polymorphisms of Metabolizing Enzymes with Clinical Outcomes Following Intravenous Paracetamol in Preterm Neonates	11

Rapid and Comprehensive Identification of Vincosamide Metabolites in vitro and in vivo in Rats by Ultra-high Performance Liquid Chromatography-Quadrupole-Exactive Orbitrap-high Resolution Mass Spectro	10
The Impacts and Changes Related to the Cancer Drug Resistance Mechanism	10
The Magic of Drug Targeting Is “Secretly” Tied to Optimal Drug Distribution and Exposure	10
Inhibition of Glycyrrhiza Polysaccharide on Human Cytochrome P450 46A1 in vitro and in vivo: Implications in Treating Neurological Diseases	10
Meet the Associate Editor	10
Development of Transdermal Drug Delivery Approaches to Combat Diabetes: An Update	9
Evaluation of Supervised Machine Learning Algorithms and Computational Structural Validation of Single Nucleotide Polymorphisms Related to Acute Liver Injury with Paracetamol	9
Strain Evaluation and Multi-Generational Stability of Cordyceps militaris for Functional Bioactive Compound Production	8
Association of UGT1A Gene Polymorphisms with BKV Infection in Renal Transplantation Recipients	8
Pharmacokinetic Interaction between Imatinib and Tacrolimus in Rats	8
Comparative Analysis of Pharmacokinetics and Metabolites of Three Main Terpenoids before and after Compatibility of Frankincense and Myrrh in Rats by UHPLC-MS	8
Meet the Editorial Board Member	8
Corrigendum To: Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates	8
The Effect of Coenzyme Q10 as a Part of Standard Therapy on Plasma Concentrations of Ubiquinol, Ubiquinone, Total CoQ10 and its Redox State in Patients with Ischemic Heart Disease	8
Influence of Orange Oil on Skin Permeability, Dermatokinetics, and In Vivo Anti-inflammatory Properties of Lornoxicam-loaded Niosomal Gel	7
The Metabolic Pathways and Products of Ten Aconitum Alkaloids in Sanwujiao Pills from Eight Organs of Mice by UHPLC-Q-TOF-MS/MS	7
Research Progress of Epigenetic Modification on the Regulation of Transporters Under Hypoxia	7
Lingguizhugan Decoction Improved Obesity by Modulating the Gut Microbiota and its Metabolites in Mice	7
Investigating the Metabolic Mechanisms of Butaselen, An Ebselen Analog	7
Deciphering the Impact of Protein Corona on Biological Fate of Nanomedicine-Loaded Microneedles	7
Natural Compounds as Potential Therapeutics for Pancreatic Cancer: A Narrative Review	7
Drug Metabolizing Enzymes: An Exclusive Guide into Latest Research in Pharmaco-genetic Dynamics in Arab Countries	7
Genetic Testing is Superior Over Endogenous Pharmacometabolomic Markers to Predict Safety of Haloperidol in Patients with Alcohol-induced Psychotic Disorder	7
Worldwide Prevalence of Polypharmacy: A Systematic Review	7
Comparative In Vitro Metabolic Profile Study of Five Cathinone Derivatives	7
Effect of Dexketoprofen on the Disposition Kinetics of Moxifloxacin in Plasma and Lung in Male and Female Rats	6
Pharmacokinetic/Pharmacodynamic Study of Salt-Processed Product of Cuscutae Semen with Hepatoprotective Effects	6
Unraveling the Gut Microbiota-Mediated Mechanism of Guogong Jiu for Rheumatoid Arthritis Treatment through Network Pharmacology and Metabolomics	6
Pharmacokinetics and Tissue Distribution of Isovitexin-2''-O-β-D-glucopyranoside (IVG) in Sprague-Dawley Rats	6
The Impact of Certain Pharmacogenetic Differences on the Metabolism of Antiretroviral Drugs Used in A Black South African Population	6
Hydrogen Peroxide Induces Ethanol-inducible CYP2E1 via the NF-kB-classical Pathway: CYP2E1 mRNA Levels are not High in Alcoholic Hepatitis	6
The Application of Nucleic Acid Nanomaterials in the Treatment of Mitochondrial Dysfunction	6
Branched-Chain Amino Acids (BCAAs): Metabolism and Their Roles In Inflammation Regulation and Disease	6
In vivo Metabolism of Nifurtimox and the Drug-Drug Interaction Potential Including its Major Metabolites	6
In Vitro Drug–Drug Interactions between Oxycodone and Commonly Co-Consumed Drugs in Rat and Human Liver Microsomes	6
Comparative Proteomics of Hepatocytes And Hepatic Cell Lines Using Swath-MS Reveals Significant Variations In Proteins Involved In Energy, Lipid, And Xenobiotic Metabolism	6
The Application of Artificial Intelligence in Drug ADME Research	6
A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look	6
The Multifaceted Role of Cytochrome P450 Isoenzymes in Alcoholic and Metabolic (Dysfunction) Fatty Liver Diseases	5
Comprehensive Metabolism Study of Tangeretin in Rat Plasma, Urine and Faeces Using Ultra-High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole- Orbitrap High-Resolution Accurate Mass Spe	5
Effects of CYP2B6 Genetic Variants on the Propofol Dose and Response among Jordanian Arabic Patients Undergoing General Anesthesia	5
Cabozantinib Carries the Risk of Drug-Drug Interactions via Inhibition of UDPglucuronosyltransferase (UGT) 1A9	5
Nicotinamide N-Methyltransferase (NNMT): A Central Regulator in Hepatocellular Carcinoma Metabolism and Therapeutic Targeting - A Systematic Review	5
Quality by Design Approach for the Development of Cariprazine Hydrochloride Loaded Lipid-Based Formulation for Brain Delivery via Intranasal Route	5
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines	5
Application of Physiologically Based Pharmacokinetic Modeling in the Research of Anti-HIV Drugs	5
Exploring Drug-Drug Interactions between Losartan and Carbamazepine: A Pharmacokinetic and Pharmacodynamic Study	5
Various Aspects of Fasting on the Biodistribution of Radiopharmaceuticals	5