Current Drug Metabolism

Article	Citations
ADMET Profiling in Drug Discovery and Development: Perspectives of In Silico, In Vitro and Integrated Approaches	51
Salidroside - Can it be a Multifunctional Drug?	42
Nanostructured Lipid Carriers (NLCs): Nose-to-Brain Delivery and Theranostic Application	32
Tumor Angiogenesis and VEGFR-2: Mechanism, Pathways and Current Biological Therapeutic Interventions	29
Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections	28
Polymeric Nanoparticles for Brain Drug Delivery - A Review	27
Dietary Baicalin Zinc Supplementation Alleviates Oxidative Stress and Enhances Nutrition Absorption in Deoxynivalenol Challenged Pigs	26
Nano Phytomedicine Based Delivery System for CNS Disease	24
The Current State of Potential Therapeutic Modalities for Glioblastoma Multiforme: A Clinical Review	23
Biosurfactants as a Novel Additive in Pharmaceutical Formulations: Current Trends and Future Implications	21
A Review: Effects of Macrolides on CYP450 Enzymes	20
Chloro-s-triazines-toxicokinetic, Toxicodynamic, Human Exposure, and Regulatory Considerations	19
Metabolite Identification in the Preclinical and Clinical Phase of Drug Development	19
Natural Compounds as Source of Aldose Reductase (AR) Inhibitors for the Treatment of Diabetic Complications: A Mini Review	18
Metabolism and Mechanism of Human Cytochrome P450 Enzyme 1A2	18
Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review	17
Topical Capsaicin for the Treatment of Neuropathic Pain	16
Metabolism and Pharmacological Mechanisms of Active Ingredients in Erigeron breviscapus	15
A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview	15
Murburn Precepts for Cytochrome P450 Mediated Drug/Xenobiotic Metabolism and Homeostasis	15
HMG-CoA Reductase Inhibitors (Statins) and their Drug Interactions Involving CYP Enzymes, P-glycoprotein and OATP Transporters-An Overview	15
Analysis of the Potential Association of Drug-Metabolizing Enzymes CYP2C9*3 and CYP2C19*3 Gene Variations With Type 2 Diabetes: A Case-Control Study	14
Physiologically-based Pharmacokinetic (PBPK) Modelling of Transporter Mediated Drug Absorption, Clearance and Drug-drug Interactions	13
Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters	13
Gold Nanoparticles; Potential Nanotheranostic Agent in Breast Cancer: A Comprehensive Review with Systematic Search Strategy	12

Medicinal Plants and Natural Products: More Effective and Safer Pharmacological Treatment for the Management of Obesity	12
The Role of Metabolism in Toxicity of Polycyclic Aromatic Hydrocarbons and their Non-genotoxic Modes of Action	12
Recent Advances in Nanotechnology-Based Targeted Therapeutics for Breast Cancer Management	12
Application of Advanced Technologies in Natural Product Research: A Review with Special Emphasis on ADMET Profiling	12
Applications of Machine Learning in Drug Target Discovery	11
Comparison of Bromhexine and its Active Metabolite - Ambroxol as Potential Analgesics Reducing Oxaliplatin-induced Neuropathic Pain - Pharmacodynamic and Molecular Docking Studies	11
Inhibition of Efflux Pumps by Monoterpene (α-pinene) and Impact on Staphylococcus aureus Resistance to Tetracycline and Erythromycin	11
Recent Advances in Biotransformation by Cunninghamella Species	11
Secondary Metabolites in the Treatment of Diabetes Mellitus: A Paradigm Shift	11
Mechanism of the Intestinal Absorption of Six Flavonoids from Zizyphi Spinosi Semen Across Caco-2 Cell Monolayer Model	10
Development and Validation of a Sensitive UPLC-Q-TOF-MS/MS for the Measurement of Nine Components in Rat Plasma and Tissues and its Application to Pharmacokinetics and Tissue Distribution Studies with	10
The Influence of Different Disease States on Rituximab Pharmacokinetics	10
Nanocrystals: An Approachable Delivery System for Anticancer Therapeutics	10
Absorption, Distribution, Metabolism, and Excretion of Aprocitentan, a Dual Endothelin Receptor Antagonist, in Humans	10
Research Progress of Herbal Medicines on Drug Metabolizing Enzymes: Consideration Based on Toxicology	10
Current Treatment Options for HCC: From Pharmacokinetics to Efficacy and Adverse Events in Liver Cirrhosis	9
Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update	9
Thymoquinone Lipid Nanoparticles Cut the Gordian Knots of Depression via Neuroprotective BDNF and Downregulation of Neuro-inflammatory NF-κB, IL-6, and TNF-α in LPS Treated Rats	9
An Overview of Dietary Supplements on Obesity and Type 2 Diabetes: Efficacy and Mechanisms	9
Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases and their Metabolic Profiling: Part 1	9
Recent Advances in Nanotechnology: A Novel Therapeutic System for the Treatment of Alzheimer’s Disease	9
Cytochromes P450: Role in Carcinogenesis and Relevance to Cancers	9
Protective Effects of Grape Seed Proanthocyanidin Extract in Preventing DSS Induced Ulcerative Colitis Based on Pharmacodynamic, Pharmacokinetic and Tissue Distribution	9
Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery	9
Deciphering the Role of Nanoparticle-based Treatment for Parkinson’s Disease	9
Effective Cancer Management: Inimitable Role of Phytochemical Based Nano- Formulations	8
Isolation, Docking and In Silico ADME-T Studies of Acacianol: Novel Antibacterial Isoflavone Analogue Isolated from Acacia leucophloea Bark	8
Pain Allaying Epalrestat-Loaded Lipid Nanoformulation for the Diabetic Neuropathic Pain Interventions: Design, Development, and Animal Study	8
Receptor-Mediated Targeting in Breast Cancer through Solid Lipid Nanoparticles and Its Mechanism	8
Withania somnifera in Neurological Disorders: Ethnopharmacological Evidence, Mechanism of Action and its Progress in Delivery Systems	8
The Metabolism and Pharmacokinetics of Rhein and Aurantio-Obtusin	8
Interactions Between Meropenem and Renal Drug Transporters	8
Pharmacokinetic Study of Vadadustat and High-Resolution Mass Spectrometric Characterization of its Novel Metabolites in Equines for the Purpose of Doping Control	8
An Update on the Recent Advances in Cubosome: A Novel Drug Delivery System	8
Role of Glucose Transporters in Drug Membrane Transport	8
A Decade’s Review of miRNA: A Center of Transcriptional Regulation of Drugmetabolizing Enzymes and Transporters under Hypoxia	8
Hepatoprotective Role of Berberine on Doxorubicin Induced Hepatotoxicity - Involvement of Cyp	7
Simultaneous Method Development and Validation of Anastrozole Along with Piperine: Degradation Studies and Degradants Characterization Using LC-QTOF-ESI-MS Along with In-silico ADMET Prediction	7
Structure of the Blood Brain Barrier and its Role in the Transporters for the Movement of Substrates across the Barriers	7
Role of Genetic Polymorphisms of Cytochrome P450 2C19 in Pantoprazole Metabolism and Pantoprazole-based Helicobacter pylori Eradication Regimens	7
Relevance of ABC Transporters in Drug Development	7
Review of the Clinical Pharmacokinetics, Efficacy and Safety of Pembrolizumab	7
Gut Microbiota as the Potential Mechanism to Mediate Drug Metabolism Under High-altitude Hypoxia	7
Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases and their Metabolic Profiling - Part 3	7
Absorption, Metabolism, Distribution, and Excretion of Letermovir	7
The Genetic Polymorphism of CYP3A4 rs2242480 is Associated with Sirolimus Trough Concentrations Among Adult Renal Transplant Recipients	7
The Influences and Mechanisms of High-altitude Hypoxia Exposure on Drug Metabolism	7
Bibliometric Analysis of Current Drug Metabolism: The Twentieth Anniversary from 2000-2019	6
Antibiotics as Inhibitor of Glutathione S-transferase: Biological Evaluation and Molecular Structure Studies	6
Study on the Plasma Protein Binding Rate and Compatibility Regularity of the Constituents Migrating to Blood of Simiao Yong’an Decoction	6

Recent Progress on Mass Spectrum Based Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Traditional Chinese Medicine	6
The Role of Biotransformation in the Activity of Endocrine Disruptors	6
Approaches to Address PK-PD Challenges of Conventional Liposome Formulation with Special Reference to Cancer, Alzheimer's, Diabetes, and Glaucoma: An Update on Modified Liposomal Drug Delivery System	6
Regulatory Effects of N-3 PUFAs on Pancreatic β-cells and Insulin-sensitive Tissues	6
A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look	6
Rapid Profiling and Identification of Vitexin Metabolites in Rat Urine, Plasma and Faeces after Oral Administration Using a UHPLC-Q-Exactive Orbitrap Mass Spectrometer Coupled with Multiple Data-minin	6
Impact of Pharmacogenetic Determinants of Tacrolimus and Mycophenolate on Adverse Events in Renal Transplant Patients	6
Tumor-targeted Drug Delivery by Nanocomposites	6
Risk Assessment of Veterinary Drug Residues in Meat Products	6
Effects of Fasting andPhoenix dactyliferaon the Expression of Major Drug- Metabolizing Enzymes in the Mouse Livers	5
In vitro Metabolism of Humantenine in Liver Microsomes from Human, Pig, Goat and Rat	5
Recent Advances on Antioxidant Identification Based on Machine Learning Methods	5
A Novel Nanoformulation of Ellagic Acid is Promising in Restoring Oxidative Homeostasis in Rat Brains with Alzheimer’s Disease	5
Role of Natural Products in the Treatment of Obesity: Nanotechnological Perspectives	5
Annonaceae Family Alkaloids as Agents Against Leishmaniasis: A Review and Molecular Docking Evaluation	5
Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction	5
Advances in Hybrid Vesicular-based Drug Delivery Systems: Improved Biocompatibility, Targeting, Therapeutic Efficacy and Pharmacokinetics of Anticancer Drugs	5
Impact of Drug Metabolism/Pharmacokinetics and its Relevance Considering Traditional Medicine-based Anti-COVID-19 Drug Research	5
Vitamin D Metabolism Gene Polymorphisms and Their Associated Disorders: A Literature Review	5
Recent Patents, Regulatory Issues, and Toxicity of Nanoparticles in Neuronal Disorders	5
Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement	5
Pharmacokinetics-based Chronotherapy	5
New Horizons in the Treatment of Neurological Disorders with Tailorable Gold Nanoparticles	5
Elevated Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Predict Drug-Induced Acute Kidney Injury	5
Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic	5
Molecular Modeling Studies on Cytochrome P450-mediated Drug Metabolism	5
The Current Application of LC-MS/MS in Pharmacokinetics of Traditional Chinese Medicines (Recent Three Years): A Systematic Review	5
A Comprehensive Review of the Pharmacologic Perspective on Loop Diuretic Drug Interactions with Therapeutically Used Drugs	5
Predicted Contributions of Flavin-containing Monooxygenases to the N-oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants	5
Factors Influencing ADME Properties of Therapeutic Antisense Oligonucleotides: Physicochemical Characteristics and Beyond	5
Aceclofenac-Loaded Microspheres Prepared by Vesicular Ionotropic Gelation to Minimize Drug-induced Gastric Ulcers in Rats	5
An Overview of the Neuropharmacological Potential of Thymoquinone and its Targeted Delivery Prospects for CNS Disorder	5
In Silico ADMET Evaluation of Natural DPP-IV Inhibitors for Rational Drug Design against Diabetes	4
Nucleic Acid Nanomaterials-based Therapy for Osteoarthritis: Progress and Prospects	4
The Influence of Kidneys Ion Transport Inhibitors on the Pharmacokinetic and Tumor Uptake Behaviors of a HER2-targeted Small Size Radiolabeled Peptide	4
Modulation of the Drug Resistance by Platonia insignis Mart. Extract, Ethyl Acetate Fraction and Morelloflavone/Volkensiflavone (Biflavonoids) in Staphylococcus aureus Strains Overexpressing Efflux Pu	4
Circadian Timekeeping in Anticancer Therapeutics: An Emerging Vista of Chronopharmacology Research	4
Targeting the Pathological Hallmarks of Alzheimer’s Disease Through Nanovesicleaided Drug Delivery Approach	4
Current Advances in Drug Delivery Systems for Capsule Endoscopy	4
Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme	4
Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases & their Metabolic Profiling-Part 2	4
Artificial Intelligence in Drug Formulation and Development: Applications and Future Prospects	4
Pharmacokinetics and Metabolism of Traditional Chinese Medicine in the Treatment of COVID-19	4
Machine Learning in Drug Metabolism Study	4
Unveiling the Role of Cytochrome P450 (2E1) in Human Brain Specifically in Parkinson’s Disease - Literature Review	4
Simultaneous Determination of Saponins and Lignans in Rat Plasma by UPLC- MS/MS and its Application to a Pharmacokinetic Study of Shenqi Jiangtang Granule	4
Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Polygonatum sibiricum Polysaccharide on Type 2 Diabetes Mellitus Model Rats	4
Current Trends for Rationalizing Brain Targeting Nanoparticles in Neurological Disorders (Part-I)	4
Effect of Atorvastatin on Single Oral Pharmacokinetics and Safety of Daclatasvir in Rats: Emphasis on P-glycoprotein and Cytochrome P450	4
Chemistry and Antioxidant Potential of Phytoconstituents from Aegle Marmelos Fruit-Shell	4
Differential Impacts of Azole Antifungal Drugs on the Pharmacokinetic Profiles of Dasatinib in Rats by LC-MS-MS	4
CYP2C and CYP2B Mediated Metabolic Activation of Retrorsine in Cyp3a Knockout Mice	4
Suppression of Melanoma Growth in a Murine Tumour Model Using Orthosiphon stamineus Benth. Extract Loaded in Ethanolic Phospholipid Vesicles (Spherosome)	4
Orchestration of Obesolytic Activity of Microbiome: Metabiotics at Centre Stage	4
Dermatokinetics: Advances and Experimental Models, Focus on Skin Metabolism	4
Lipid Nanoformulations in the Treatment of Neuropsychiatric Diseases: An Approach to Overcome the Blood Brain Barrier	3
Pharmacokinetic Drug-Drug Interactions Involving Antiretroviral Agents: An Update	3
New Ultra Low Volume Bowel Preparation and Overview of Existing Bowel Preparations	3
Improved Therapeutic Efficacy of Topotecan Against A549 Lung Cancer Cells with Folate-targeted Topotecan Liposomes	3
Molecular Insights into the Mechanism of Modulatory Effects of Proton Pump Inhibitors on P-glycoprotein Mediated Drug Transport of Palbociclib and Ribociclib	3
Nanotechnological Approaches for the Treatment of Triple-Negative Breast Cancer: A Comprehensive Review	3
Insights into Interactions of Human Cytochrome P450 17A1: A Review	3
Human Orphan Cytochromes P450: An Update	3
Evaluating Lean Liver Volume as a Potential Scaler for In Vitro-In Vivo Extrapolation of Drug Clearance in Obesity Using the Model Drug Antipyrine	3
Amino Acid and Biogenic Amine Adductions Derived from Reactive Metabolites	3
Comparison between Atorvastatin and Rosuvastatin on Secondary Percutaneous Coronary Intervention Rate and the Risk Factors in Patients with Coronary Heart Disease	3
The Development of a Physiologically Based Pharmacokinetic (PBPK) Model of Andrographolide in Mice and Scaling it up to Rats, Dogs, and Humans	3
Inhibition of Cytochrome P450 Enzyme and Drug-Drug Interaction Potential of Acid Reducing Agents Used in Management of CDK Inhibitors for Breast Cancer Chemotherapy	3
Pharmacokinetics and Efficacy of Ceftriaxone in Staphylococcal Mastitis in Crossbred Cows Following Single Intravenous Administration	3
Pharmacokinetic Research Progress of Anti-tumor Drugs Targeting for Pulmonary Administration	3
Anticancer Activity and In Silico ADMET Properties of 2,4,5-Trisubstitutedthiazole Derivatives	3
Detection and Identification of Catalpol Metabolites in the Rat Plasma, Urine and Faeces Using Ultra-high Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole-orbitrap High-resolution Accura	3
Absorption, Disposition and Pharmacokinetic Properties of Novel Therapeutic Modalities	3
Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China	3
Modulation of Drug Resistance by Limonene: Inhibition of Efflux Pumps in Staphylococcus aureus Strains RN-4220 and IS-58	3
Comprehensive Identification of Astilbin Metabolites in Rats Based on Multiple Metabolite Templates Combined with UHPLC-Q-Exactive Mass Spectrometry	3
A HPLC-DAD-MS/MS Method for Simultaneous Determination of Six Active Ingredients of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in Rat Plasma and its Application to Pharmacokinetic	3
Influence of SLCO1B1 Polymorphisms on the Pharmacokinetics of Mycophenolic Acid in Renal Transplant Recipients	3
Biotransformation of Drugs and other Xenobiotics as Key Modulator of Toxicity	3
Phytofabricated Nanoparticle Formulation for Cancer Treatment: A Comprehensive Review	3

A Review On Huntington Protein: Insight Into Protein Aggregation and Therapeutic Interventions	3
Advances in Understanding the Metabolites and Metabolomics of Polygonum multiflorum Thunb: A Mini-review	3
In Silico Pharmacokinetic Study of Vancomycin Using PBPK Modeling and Therapeutic Drug Monitoring	3
In Silico Meets In Vitro Techniques in ADMET Profiling of Drug Discovery (Part I)	3
Effects of Astragaloside IV on the Pharmacokinetics of Metoprolol in Rats and its Mechanism	3
Nanotechnology Driven Approaches for the Management of Parkinson’s Disease: Current Status and Future Perspectives	3
Cabozantinib Carries the Risk of Drug-Drug Interactions via Inhibition of UDPglucuronosyltransferase (UGT) 1A9	3
The Function of Multidrug Resistance-associated Protein 3 in the Transport of Bile Acids under Normal Physiological and Lithocholic Acid-induced Cholestasis Conditions	2
Changing Pain Management Strategy from Opioid-centric Towards Improve Postoperative Cognitive Dysfunction with Dexmedetomidine	2
Comparison of the Inhibitory Effects of Clotrimazole and Ketoconazole against Human Carboxylesterase 2	2
Impact of POR*28 Variant on Tacrolimus Pharmacokinetics in Kidney Transplant Patients with Different CYP3A5 Genotypes	2
Comparative Pharmacokinetics of Intravenous Enrofloxacin in One- Six- And Twelve-Month-Old Sheep	2
Metabolic Activation of Retrorsine may Disrupt Bile Acid Homeostasis in Mice through the Nrf2 Pathway	2
Hepatic Effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, the Signature Component of Traditional Chinese Medicine Heshouwu: Advances and Prospects	2
Characterization of Metabolites of α-mangostin in Bio-samples from SD Rats by UHPLC-Q-exactive Orbitrap MS	2
Covalent CES2 Inhibitors Protect against Reduced Formation of Intestinal Organoids by the Anticancer Drug Irinotecan	2
Physiologically-Based Pharmacokinetic Modeling of Tenofovir Disoproxil Fumarate in Pregnant Women	2
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPARγ, and TGF-β/Smad Pathways in Mice	2
Drug-gut Microbiome Interaction in Atherosclerosis Therapeutics	2
A Comprehensive Study on the Chemical Constituents and Pharmacokinetics of Erzhi Formula and Jiawei Erzhi Formula Based on Targeted and Untargeted LC-MS Analysis	2
A Systematic Review of Linezolid Pharmacokinetics/Pharmacodynamics in Patients Undergoing Continuous Renal Replacement Therapy: Does One Size Fit All?	2
Nanoparticle-Based Inhalation Therapy for Pulmonary Diseases	2
Effectiveness and Tolerability of Very-low Volume Preparation for Colonoscopy: A Narrative Review	2
Methods to Improve the Stability of Nucleic Acid-Based Nanomaterials	2
A Randomized Trial of Short-term Treatment with Folic Acid to Reduce the Oxidative Stress of Patients with Chronic Kidney Disease	2
Updates on the Pharmacology of Chloroquine against Coronavirus Disease 2019 (COVID-19): A Perspective on its Use in the General and Geriatric Population	2
Stability of Ketoprofen Methylester in Plasma of Different Species	2
Substrate-dependent Inhibition of Hypericin on Human Carboxylesterase 2: Implications for Herb-drug Combination	2
Evaluation of Dermorphin Metabolism Using Zebrafish Water Tank Model and Human Liver Microsomes	2
Metabolism of Direct-acting Antiviral Agents (DAAs) in Hepatitis C Therapy: A Review of the Literature	2
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke	2
Nanostructured Therapeutic Systems of PUFAs for the Treatment of Glioblastoma Multiforme	2
Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates	2
Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic Receptor Blocker, 101BHG-D01, in Dogs and Rats	2
DNA-based Nanomaterials in the Immunotherapy	2
Absorption, Disposition and Pharmacokinetic Properties of Novel Therapeutic Modalities (Part II)	2
Identification and Quantification of MIDD0301 Metabolites	2
Investigating the Metabolic Mechanisms of Butaselen, An Ebselen Analog	2
Trends in Rationalized Brain Targeted Nanoparticles in Neurological Disorders (Part-III)	2
miRNAs in SARS-CoV-2 Infection: An Update	2
Application of Nucleic Acid Nanomaterials in the Treatment of Endocrine and Metabolic Diseases	2
Comparative Study of Binding Pockets in Human CYP1A2, CYP3A4, CYP3A5, and CYP3A7 with Aflatoxin B1, a Hepato-Carcinogen, by Molecular Dynamics Simulation & Principal Component Analysis	2
Comprehensive Metabolism Study of Tangeretin in Rat Plasma, Urine and Faeces Using Ultra-High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole- Orbitrap High-Resolution Accurate Mass Spe	2
New Psychoactive Substances, New Behaviours, New Drug-drug Interactions: Pharmacology of a Slam Session	2
Integrated UPLC-MS/MS and UHPLC-Q-orbitrap HRMS Analysis to Reveal Pharmacokinetics and Metabolism of Five Terpenoids from Alpiniae oxyphyllae Fructus in Rats	2
How Antimalarials and Antineoplastic Drugs can Interact in Combination Therapies: A Perspective on the Role of PPT1 Enzyme	2
Framework Nucleic Acids: A Promising Vehicle for Small Molecular Cargos	2
The Application of Nucleic Acid Nanomaterials in the Treatment of Mitochondrial Dysfunction	2
Malaria-induced Alterations of Drug Kinetics and Metabolism in Rodents and Humans	2
Preclinical Pharmacokinetics and CYP Modulation Activity of Chebulinic Acid: A Potent Molecule Against Metabolic Disease	2
Characterization of Dicaffeoylspermidine Derivatives from Wolfberry as Potent and Selective Inhibitors of Human Cytochrome P450 46A1 In vitro	2
Physiologically Based Pharmacokinetic Model for Older Adults and Its Application in Geriatric Drug Research	2
High-throughput LC-MS/MS Method for Simultaneous Determination of Pantoprazole and Atorvastatin in Rat Plasma: Application to a Pharmacokinetic Interaction Study	2
Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo	2
Comparison of Intra and Post-operative Sedation Efficacy of Dexmedetomidinemidazolam and Dexmedetomidine-propofol for Major Abdominal Surgery	2
Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan	2
Synthesis and Biomedical Applications of DNA Hydrogel	2
State-of-the-art Application of Artificial Intelligence to Transporter-centered Functional and Pharmaceutical Research	1
UPLC-ESI-Q-TOF/MS Based Metabolic Profiling of Protosappanin B in Rat Plasma, Bile, Feces, Urine and Intestinal Bacteria Samples	1
In-vitro and In-vivo Identification, Absorbtion and Metabolism Network Analysis of Filifolium sibiricum Flavonoids Dropping Pill by UHPLC-Q-TOF-MS	1
The Metabolism of the New Benzodiazepine Remimazolam	1
Mitochondrial Biotransformation of Drugs and other Xenobiotics	1
Different Inductive Effects of Praziquantel Racemate and its Enantiomers on the Enzyme CYP3A4 Mediated by Pregnane X Receptor and its Variants	1
Effects of Montmorillonite on Growth Performance, Serum Biochemistry and Oxidative Stress of Red-Crowned Crane (Grus japonensis) Fed Mycotoxin-Contaminated Feed	1
New Devices for Endoscopic Treatments in Gastroenterology: A Narrative Review	1
Drug Induced Cutaneous Manifestations due to Treatment of Gastrointestinal Disorders	1
A Mini-review on Recent Strategies and Applications of Nanomedicines to Combat Antimicrobial Resistance	1
Rapid Profiling of the Marker Components in Artemisia annua L. and their Metabolites in Rats Using an Improved Liquid Chromatography-tandem Highresolution Mass Spectrometry-based Technology	1
Design and Evaluation of Sustained Release of Ornidazole by Dental Inserts	1
Effect of Carbonized Herba schizonepetae on the Bioavailability of Eight Active Components from Pulsatillae Decoction in its Particular Adsorption and Release Performance	1
Interactions of Betel Quid Constituents with Drug Disposition Pathways: An Overview	1
Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans	1
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines	1
Evaluation and Clinical Implication of Zhenwu Decoction on Seven Cytochrome P450 Enzyme in Chronic Heart Failure Rats	1
Recent Advances in Novel Recombinant RNAs for Studying Post-transcriptional Gene Regulation in Drug Metabolism and Disposition	1
The Impacts and Changes Related to the Cancer Drug Resistance Mechanism	1
No Effect of PXR (8055C>T) Polymorphism on the Pharmacokinetic Profiles of Piperaquine in Healthy Chinese Subjects	1
Influence of Zhuanggu Guanjie Pill on Seven Cytochrome P450 Enzymes Based on Probe Cocktail and Pharmacokinetics Approaches	1
Clay-based Formulations for Bioavailability Enhancement of Poorly Water-soluble Drugs	1
Additive Manufacturing and Printing Approaches for the Development of Pharmaceutical Dosage Forms with Improved Biopharmaceutical Attributes	1
Meropenem for the Pharmacological Treatment of Severe Infections in Critically Ill Pediatric Patients: Breakthrough Standard Treatment Strategies Based on PK/PD	1
The Emerging Roles of Extracellular Vesicles in Ovarian Cancer	1
Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery	1
Pharmacokinetic/Pharmacodynamic Study of Salt-Processed Product of Cuscutae Semen with Hepatoprotective Effects	1
Concomitant Drug Treatment and Elimination in the RCC-affected Kidneys: Can We Kill Two Birds with One Stone?	1
Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Mediate the Disposition of Leonurine-10-O-β-glucuronide	1
Withdrawal Notice: Synergistic Effect of Myricetin and Phenolic Acid Derivatives on the Reversal of Dengue Fever Related Thrombocytopenia and its Pharmacokinetics study in Plasma by using HPLC and UPL	1
The Effect of Coenzyme Q10 as a Part of Standard Therapy on Plasma Concentrations of Ubiquinol, Ubiquinone, Total CoQ10 and its Redox State in Patients with Ischemic Heart Disease	1
Comparative Pharmacokinetics of Scoparone and its Metabolite Scopoletin in Normal and ANIT-induced Intrahepatic Cholestatic Rats	1
Evaluation of Alterations in DNA Methylation of CYP3A4 Gene Upstream Regulatory Elements in Gastric Cancer and in Response to Diazinon Treatment	1
A Randomized Study on the Bioequivalence of Desloratadine in Healthy Chinese Subjects and the Association of Different Metabolic Phenotypes With UGT2B10 and CYP2C8 Genotypes	1
Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like Factor 9 (KLF9)	1
The Promising Role of Natural Exosomal Nanoparticles in Cancer Chemoimmunotherapy	1
Study on the Relationship between Rivaroxaban and Factor Xa Activity in Blood Based on HPLC-MS/MS	1
Design and Construction of Carboxylesterase 2c Gene Knockout Rats by CRISPR/Cas9	1