Current Drug Metabolism

Papers
(The median citation count of Current Drug Metabolism is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery70
Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic Receptor Blocker, 101BHG-D01, in Dogs and Rats22
Metabolic Activation of Retrorsine may Disrupt Bile Acid Homeostasis in Mice through the Nrf2 Pathway22
Novel Techniques and Models for Studying Drug Metabolism and Transport20
Theoretical Evaluation of Oleocanthal Reactive Centers18
In vitro and In vivo Drug Metabolism Analysis of BPI-460372 - A Covalent TEAD1/3/4 Inhibitor17
Potential Alteration of Rifampicin’s Bioavailability by Phyllanthus niruri Supplementation in Tuberculosis Therapy16
Deciphering the Role of Nanoparticle-based Treatment for Parkinson’s Disease16
Interactions of Betel Quid Constituents with Drug Disposition Pathways: An Overview16
The Influences and Mechanisms of High-altitude Hypoxia Exposure on Drug Metabolism15
Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Polygonatum sibiricum Polysaccharide on Type 2 Diabetes Mellitus Model Rats15
Interactions Between Meropenem and Renal Drug Transporters15
Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme15
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke15
Tacrolimus, Cytochrome P450, Interactions with Food Variables in Organ Transplant Recipients; A Current and Comprehensive Review14
ADMET Profiling in Drug Discovery and Development: Perspectives of In Silico, In Vitro and Integrated Approaches14
Regulation of Gut Microbiota by Herbal Medicines13
Pharmacokinetics and Efficacy of Ceftriaxone in Staphylococcal Mastitis in Crossbred Cows Following Single Intravenous Administration13
Rapid Profiling of the Marker Components in Artemisia annua L. and their Metabolites in Rats Using an Improved Liquid Chromatography-tandem Highresolution Mass Spectrometry-based Technology13
Meet the Section Editor13
Suppression of Melanoma Growth in a Murine Tumour Model Using Orthosiphon stamineus Benth. Extract Loaded in Ethanolic Phospholipid Vesicles (Spherosome)12
Urine Metabolites as a Predictor of Warfarin Response Based on INR in Atrial Fibrillation12
Role of Cytochrome P450 3A4 in Cancer Drug Resistance: Challenges and Opportunities12
Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review12
The Function of Multidrug Resistance-associated Protein 3 in the Transport of Bile Acids under Normal Physiological and Lithocholic Acid-induced Cholestasis Conditions11
Inhibition of Glycyrrhiza Polysaccharide on Human Cytochrome P450 46A1 in vitro and in vivo: Implications in Treating Neurological Diseases11
Influence of Zhuanggu Guanjie Pill on Seven Cytochrome P450 Enzymes Based on Probe Cocktail and Pharmacokinetics Approaches11
Meet the Associate Editorial Board Member10
Meet the Associate Editor10
Nucleic Acid Nanomaterials: Biostability and Applications10
Absorption, Metabolism, Distribution, and Excretion of Letermovir10
WITHDRAWN: Pharmacokinetic Drug Interactions of Piperine: A Review of Pre-clinical and Clinical Studies9
Circadian Timekeeping in Anticancer Therapeutics: An Emerging Vista of Chronopharmacology Research9
Comparative Analysis of Machine Learning Algorithms Evaluating the Single Nucleotide Polymorphisms of Metabolizing Enzymes with Clinical Outcomes Following Intravenous Paracetamol in Preterm Neonates 9
Meet the Editorial Board Member9
The Impacts and Changes Related to the Cancer Drug Resistance Mechanism9
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The Effect of Coenzyme Q10 as a Part of Standard Therapy on Plasma Concentrations of Ubiquinol, Ubiquinone, Total CoQ10 and its Redox State in Patients with Ischemic Heart Disease8
Relevance of ABC Transporters in Drug Development8
Meet the Associate Editor8
Nanotechnology Driven Approaches for the Management of Parkinson’s Disease: Current Status and Future Perspectives8
Evaluation of Supervised Machine Learning Algorithms and Computational Structural Validation of Single Nucleotide Polymorphisms Related to Acute Liver Injury with Paracetamol8
Pharmacokinetic Interaction between Imatinib and Tacrolimus in Rats8
In vitro Measurement and In vivo Prediction of Time-Dependent Inhibitory Effects of Three Tyrosine Kinase Inhibitors on CYP3A Activity8
Association of UGT1A Gene Polymorphisms with BKV Infection in Renal Transplantation Recipients7
The Metabolic Pathways and Products of Ten Aconitum Alkaloids in Sanwujiao Pills from Eight Organs of Mice by UHPLC-Q-TOF-MS/MS7
Metabolism is not a Major Contributor to the Toxicity of Piperaquine, a Long-acting Antimalarial Agent in Artemisinin-based Combination Therapy7
Rapid and Comprehensive Identification of Vincosamide Metabolites in vitro and in vivo in Rats by Ultra-High Performance Liquid Chromatography-Quadrupole- Exactive Orbitrap-High Resolution Mass Spectr7
Investigating the Metabolic Mechanisms of Butaselen, An Ebselen Analog7
Meet the Editorial Board Member7
Genetic Testing is Superior Over Endogenous Pharmacometabolomic Markers to Predict Safety of Haloperidol in Patients with Alcohol-induced Psychotic Disorder7
Drug Metabolizing Enzymes: An Exclusive Guide into Latest Research in Pharmaco-genetic Dynamics in Arab Countries6
In vivo Metabolism of Nifurtimox and the Drug-Drug Interaction Potential Including its Major Metabolites6
Worldwide Prevalence of Polypharmacy: A Systematic Review6
Meet the Editorial Board Member6
Overexpression of MRP3 in HeLa-UGT1A9 Cells Enhances Glucuronidation Capability of the Cells6
Effect of Dexketoprofen on the Disposition Kinetics of Moxifloxacin in Plasma and Lung in Male and Female Rats6
Comparative Analysis of Pharmacokinetics and Metabolites of Three Main Terpenoids before and after Compatibility of Frankincense and Myrrh in Rats by UHPLC-MS6
Influence of CYP2C9 Polymorphisms on Plasma Concentration of Warfarin and 7-Hydroxy Warfarin in South Indian Patients6
Effects of Fasting andPhoenix dactyliferaon the Expression of Major Drug- Metabolizing Enzymes in the Mouse Livers6
Nanostructured Therapeutic Systems of PUFAs for the Treatment of Glioblastoma Multiforme6
Corrigendum To: Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates6
Comparative in Vitro Metabolic Profile Study of Five Cathinone Derivatives6
Lingguizhugan Decoction Improved Obesity by Modulating the Gut Microbiota and its Metabolites in Mice5
UPLC-ESI-Q-TOF/MS Based Metabolic Profiling of Protosappanin B in Rat Plasma, Bile, Feces, Urine and Intestinal Bacteria Samples5
Gut Microbiota as the Potential Mechanism to Mediate Drug Metabolism Under High-altitude Hypoxia5
Study on the Relationship between Rivaroxaban and Factor Xa Activity in Blood Based on HPLC-MS/MS5
Orchestration of Obesolytic Activity of Microbiome: Metabiotics at Centre Stage5
Meet the Co-Editor5
Research Progress of Epigenetic Modification on the Regulation of Transporters Under Hypoxia5
A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look5
Chloro-s-triazines-toxicokinetic, Toxicodynamic, Human Exposure, and Regulatory Considerations5
Additive Manufacturing and Printing Approaches for the Development of Pharmaceutical Dosage Forms with Improved Biopharmaceutical Attributes5
Hydrogen Peroxide Induces Ethanol-inducible CYP2E1 via the NF-kB-classical Pathway: CYP2E1 mRNA Levels are not High in Alcoholic Hepatitis5
Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates5
The Application of Nucleic Acid Nanomaterials in the Treatment of Mitochondrial Dysfunction5
The Impact of Certain Pharmacogenetic Differences on the Metabolism of Antiretroviral Drugs Used in A Black South African Population5
Pharmacokinetic/Pharmacodynamic Study of Salt-Processed Product of Cuscutae Semen with Hepatoprotective Effects5
Effects of CPY3A5 Genetic Polymorphisms on the Pharmacokinetics of Extendedrelease and Immediate-release Tacrolimus Formulations in Renal Transplant Recipients: A Systematic Review and Meta-analysis5
Pharmacokinetics and Tissue Distribution of Isovitexin-2''-O-β-D-glucopyranoside (IVG) in Sprague-Dawley Rats5
Nutritional Therapy Strategies Targeting Tumor Energy Metabolism4
Metabolite Identification in the Preclinical and Clinical Phase of Drug Development4
Quality by Design Approach for the Development of Cariprazine Hydrochloride Loaded Lipid-Based Formulation for Brain Delivery via Intranasal Route4
miRNAs in SARS-CoV-2 Infection: An Update4
Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction4
Meet the Editorial Board Member4
Effects of CYP2B6 Genetic Variants on the Propofol Dose and Response among Jordanian Arabic Patients Undergoing General Anesthesia4
Impact of Drug Metabolism/Pharmacokinetics and its Relevance Considering Traditional Medicine-based Anti-COVID-19 Drug Research4
Umbelliferone Enhances Immune Function in Cyclophosphamide-Induced Immunosuppressed Mice via Histidine and Purine Metabolism Regulation4
In Silico Tools to Thaw the Complexity of the Data: Revolutionizing Drug Research in Drug Metabolism, Pharmacokinetics and Toxicity Prediction4
Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model4
Meet the Regional Editor4
An Efficient Integrated Strategy for Comprehensive Metabolite Profiling of Sakurasosaponin from Aegiceras corniculatum in Rats4
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines4
Various Aspects of Fasting on the Biodistribution of Radiopharmaceuticals4
Evaluation of Alterations in DNA Methylation of CYP3A4 Gene Upstream Regulatory Elements in Gastric Cancer and in Response to Diazinon Treatment4
The Development of a Physiologically Based Pharmacokinetic (PBPK) Model of Andrographolide in Mice and Scaling it up to Rats, Dogs, and Humans4
Machine Learning in Drug Metabolism Study4
Effect of Salbutamol on the Disposition Kinetics of Levofloxacin in the Plasma and Lung of Rats4
DNA-based Nanomaterials in the Immunotherapy4
Exploring Drug-Drug Interactions between Losartan and Carbamazepine: A Pharmacokinetic and Pharmacodynamic Study4
Unraveling the Role of COMT Polymorphism in Dopamine-Mediated Vasopressor Effects: An Observational Cross-Sectional Study4
Effect of Wuzhi Capsule (WZC) on the Pharmacokinetics of Tacrolimus in Renal Transplantation Recipients4
Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update4
A Novel Nanoformulation of Ellagic Acid is Promising in Restoring Oxidative Homeostasis in Rat Brains with Alzheimer’s Disease4
Comprehensive Identification of Astilbin Metabolites in Rats Based on Multiple Metabolite Templates Combined with UHPLC-Q-Exactive Mass Spectrometry4
Cabozantinib Carries the Risk of Drug-Drug Interactions via Inhibition of UDPglucuronosyltransferase (UGT) 1A94
Comprehensive Metabolism Study of Tangeretin in Rat Plasma, Urine and Faeces Using Ultra-High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole- Orbitrap High-Resolution Accurate Mass Spe4
Meet the Co-Editor4
Meet the Editorial Board Member4
Pain Allaying Epalrestat-Loaded Lipid Nanoformulation for the Diabetic Neuropathic Pain Interventions: Design, Development, and Animal Study3
Effect of C. cyminum and L. sativum on Pharmacokinetics and Pharmacodynamics of Antidiabetic Drug Gliclazide3
Differential Pharmacokinetic Interplay of Atorvastatin on Lacosamide and Levetiracetam on Experimental Convulsions in Mice3
Impact of POR*28 Variant on Tacrolimus Pharmacokinetics in Kidney Transplant Patients with Different CYP3A5 Genotypes3
Anticancer Activity and In Silico ADMET Properties of 2,4,5-Trisubstitutedthiazole Derivatives3
Development and Validation of a Sensitive UPLC-Q-TOF-MS/MS for the Measurement of Nine Components in Rat Plasma and Tissues and its Application to Pharmacokinetics and Tissue Distribution Studies with3
Meet the Editorial Board Member3
Meet the Editorial Board Member3
The Metabolism of the New Benzodiazepine Remimazolam3
Hepatic Effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, the Signature Component of Traditional Chinese Medicine Heshouwu: Advances and Prospects3
Evaluation of Dermorphin Metabolism Using Zebrafish Water Tank Model and Human Liver Microsomes3
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPARγ, and TGF-β/Smad Pathways in Mice3
Biotransformation of Drugs and other Xenobiotics as Key Modulator of Toxicity3
Metabolic Pathway of Osilodrostat in Equine Urine Established through High-resolution Mass Spectrometric Characterization for Doping Control3
Quality by Design-Steered Development of Stealth Liposomal Formulation of Everolimus: A Systematic Optimization and Evaluation3
Nanotechnological Approaches for the Treatment of Triple-Negative Breast Cancer: A Comprehensive Review3
Evaluation and Clinical Implication of Zhenwu Decoction on Seven Cytochrome P450 Enzyme in Chronic Heart Failure Rats3
Unveiling the Role of Cytochrome P450 (2E1) in Human Brain Specifically in Parkinson’s Disease - Literature Review2
Simultaneous Method Development and Validation of Anastrozole Along with Piperine: Degradation Studies and Degradants Characterization Using LC-QTOF-ESI-MS Along with In-silico ADMET Prediction2
Meet the Editorial Board Member2
Study on Cytochrome P450 Metabolic Profile of Paclitaxel on Rats using QTOF-MS2
Characterization of Dicaffeoylspermidine Derivatives from Wolfberry as Potent and Selective Inhibitors of Human Cytochrome P450 46A1 In vitro2
Hepatic Metabolic Enzyme Activity with Endogenous Substances-Current Status, Challenges and Limitations2
Meet the Associate Editor2
Inhibition of Cytochrome P450 Enzyme and Drug-Drug Interaction Potential of Acid Reducing Agents Used in Management of CDK Inhibitors for Breast Cancer Chemotherapy2
Trends in Rationalized Brain Targeted Nanoparticles in Neurological Disorders (Part-III)2
Comprehensive Investigation of the Influence of High-Altitude Hypoxia on Clopidogrel Metabolism and Gut Microbiota2
Elevated Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Predict Drug-Induced Acute Kidney Injury2
Thymoquinone Lipid Nanoparticles Cut the Gordian Knots of Depression via Neuroprotective BDNF and Downregulation of Neuro-inflammatory NF-κB, IL-6, and TNF-α in LPS Treated Rats2
Comparative Pharmacokinetics of Intravenous Enrofloxacin in One- Six- And Twelve-Month-Old Sheep2
Design and Construction of Carboxylesterase 2c Gene Knockout Rats by CRISPR/Cas92
Comparative Pharmacokinetics of Scoparone and its Metabolite Scopoletin in Normal and ANIT-induced Intrahepatic Cholestatic Rats2
Drug-Protein Interactions Prediction Models Using Feature Selection and Classification Techniques2
Rapid Chemical Profiling of Compound Huanggen Granules and Absorbed Prototypes in Cynomolgus Monkey Plasma by Integrating UHPLC-Q-TOF-MSE Method and Data Post-Processing Strategy2
Fluoropyrimidine Toxicity: the Hidden Secrets of DPYD2
Meropenem for the Pharmacological Treatment of Severe Infections in Critically Ill Pediatric Patients: Breakthrough Standard Treatment Strategies Based on PK/PD2
In-vitro and In-vivo Identification, Absorbtion and Metabolism Network Analysis of Filifolium sibiricum Flavonoids Dropping Pill by UHPLC-Q-TOF-MS2
Clay-based Formulations for Bioavailability Enhancement of Poorly Water-soluble Drugs2
Approaches to Address PK-PD Challenges of Conventional Liposome Formulation with Special Reference to Cancer, Alzheimer's, Diabetes, and Glaucoma: An Update on Modified Liposomal Drug Delivery System2
Pharmacokinetics-based Chronotherapy2
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Framework Nucleic Acids: A Promising Vehicle for Small Molecular Cargos2
Comparative Study of Binding Pockets in Human CYP1A2, CYP3A4, CYP3A5, and CYP3A7 with Aflatoxin B1, a Hepato-Carcinogen, by Molecular Dynamics Simulation & Principal Component Analysis2
Pharmacokinetic Drug-Drug Interactions Involving Antiretroviral Agents: An Update2
A Phase I Clinical Study of the Pharmacokinetics and Safety of Prusogliptin Tablets in Subjects with Mild to Moderate Hepatic Insufficiency and Normal Liver Function2
Nanomedicine for Cancer: Targeted Therapy, Vaccination, Pharmacokinetics, and Challenges2
Meet the Associate Editor2
A Combination of Magnoflorine and Spinosin Improves the Antidepressant effects on CUMS Mouse Model2
Amino Acid and Biogenic Amine Adductions Derived from Reactive Metabolites2
Interaction of Intestinal Microbiota with Medications2
Factors Influencing ADME Properties Of Drugs: Advances and Applications (Part II)2
Comparison of the Inhibitory Effects of Clotrimazole and Ketoconazole against Human Carboxylesterase 22
Meet the Editorial Board Member2
Review of the Clinical Pharmacokinetics, Efficacy and Safety of Pembrolizumab2
Recent Advances in Novel Recombinant RNAs for Studying Post-transcriptional Gene Regulation in Drug Metabolism and Disposition2
Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery2
Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like Factor 9 (KLF9)2
A Comparative Study on Sedation Efficacy Between General and Regional Anesthesia with Dexmedetomidine in Patients Under Maxillofacial Surgery2
Unveiling the Interplay: Antioxidant Enzyme Polymorphisms and Oxidative Stress in Preterm Neonatal Renal and Hepatic Functions1
Effective Cancer Management: Inimitable Role of Phytochemical Based Nano- Formulations1
A Cross-sectional Comparative Analysis of Eleven Population Pharmacokinetic Models for Docetaxel in Chinese Breast Cancer Patients1
UPLC-LTQ-Orbitrap Study on Rat Urinary Metabolites of 5-Methoxy-Alpha-Methyltryptamine1
Meet the Editorial Board Member1
Aceclofenac-Loaded Microspheres Prepared by Vesicular Ionotropic Gelation to Minimize Drug-induced Gastric Ulcers in Rats1
A Decade’s Review of miRNA: A Center of Transcriptional Regulation of Drugmetabolizing Enzymes and Transporters under Hypoxia1
Phytofabricated Nanoparticle Formulation for Cancer Treatment: A Comprehensive Review1
No Effect of PXR (8055C>T) Polymorphism on the Pharmacokinetic Profiles of Piperaquine in Healthy Chinese Subjects1
A Mini-review on Recent Strategies and Applications of Nanomedicines to Combat Antimicrobial Resistance1
Effect of Carbonized Herba schizonepetae on the Bioavailability of Eight Active Components from Pulsatillae Decoction in its Particular Adsorption and Release Performance1
Where will Medicines that Serve the Global South and Economically Disadvantaged People Come From?1
Artificial Intelligence in Drug Formulation and Development: Applications and Future Prospects1
Herbal Medicines as Adjuvants for the Treatment of Chemotherapy-Induced Diarrhea1
Ceftobiprole and Cefiderocol for Patients on Extracorporeal Membrane Oxygenation: The Role of Therapeutic Drug Monitoring1
Biomimetic Nanoscale Systems for Targeted Delivery in Cancer: Current Advances and Future Prospects1
Medicinal Plants and Natural Products: More Effective and Safer Pharmacological Treatment for the Management of Obesity1
Acknowledgement to Reviewers1
Metabolic Stability and Metabolite Identification of CYP450 Probe Substrates in Ferret Hepatocytes1
State-of-the-art Application of Artificial Intelligence to Transporter-centered Functional and Pharmaceutical Research1
Vitamin D Metabolism Gene Polymorphisms and Their Associated Disorders: A Literature Review1
An Overview of the Neuropharmacological Potential of Thymoquinone and its Targeted Delivery Prospects for CNS Disorder1
Impact of Pharmacogenetic Determinants of Tacrolimus and Mycophenolate on Adverse Events in Renal Transplant Patients1
A Data Mining Approach on Polypharmacy and Drug-drug Interactions of Common Diabetes Medications1
Molecular Modeling Studies on Cytochrome P450-mediated Drug Metabolism1
Influence of SLCO1B1 Polymorphisms on the Pharmacokinetics of Mycophenolic Acid in Renal Transplant Recipients1
Effect of Atorvastatin on Single Oral Pharmacokinetics and Safety of Daclatasvir in Rats: Emphasis on P-glycoprotein and Cytochrome P4501
Identification of the Metabolites of Scutebarbatine A in Rat Plasma, Bile, Urine, and feces by Using Ultra-high-performance Liquid Chromatography Coupled with Q Exactive Hybrid Quadrupole-orbitrap Hig1
High-throughput LC-MS/MS Method for Simultaneous Determination of Pantoprazole and Atorvastatin in Rat Plasma: Application to a Pharmacokinetic Interaction Study1
Physiologically Based Pharmacokinetic Model for Older Adults and Its Application in Geriatric Drug Research1
Physiologically-Based Pharmacokinetic Modeling of Tenofovir Disoproxil Fumarate in Pregnant Women1
Acknowledgements to Reviewers1
The Promising Role of Natural Exosomal Nanoparticles in Cancer Chemoimmunotherapy1
Meet the Editorial Board Member1
Disposition Kinetics of Cathinone and its Metabolites after Oral Administration in Rats1
Characterization of Five Natural Anthraquinone Compounds as Potent Inhibitors against CYP1B1: Implications for Cancer Treatment1
Development in Drug Metabolite Profiling (Part-I)1
Comprehensive Analysis of Chemical Ingredients of Waiganfengsha Granule and Absorbed Components in Rat Plasma Based on UHPLC-Q-TOF-MS1
A Randomized Trial of Short-term Treatment with Folic Acid to Reduce the Oxidative Stress of Patients with Chronic Kidney Disease1
Comparative Analysis of the Gelsemium Alkaloids Metabolism in Human, Pig, Goat, and Rat Liver Microsomes1
A Review on Drug-Metabolizing Enzymes, Transporters, and Gut Microbiota on Pharmacokinetics in High-Altitude Environment1
Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic1
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