Current Drug Metabolism

Article	Citations
Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery	85
Metabolic Activation of Retrorsine may Disrupt Bile Acid Homeostasis in Mice through the Nrf2 Pathway	29
Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic Receptor Blocker, 101BHG-D01, in Dogs and Rats	26
Novel Techniques and Models for Studying Drug Metabolism and Transport	22
Theoretical Evaluation of Oleocanthal Reactive Centers	21
The Influences and Mechanisms of High-altitude Hypoxia Exposure on Drug Metabolism	20
In vitro and In vivo Drug Metabolism Analysis of BPI-460372 - A Covalent TEAD1/3/4 Inhibitor	20
Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme	19
Deciphering the Role of Nanoparticle-based Treatment for Parkinson’s Disease	19
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke	17
HFD-induced Alterations in Renal Tubular Oatp4c1-P-gp Transport Systems in Mice: Impact on Digoxin Renal Excretion and Gadolinium-Enhanced Radiological Manifestations	16
Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Polygonatum sibiricum Polysaccharide on Type 2 Diabetes Mellitus Model Rats	16
Meet the Section Editor	14
Interactions Between Meropenem and Renal Drug Transporters	14
Interactions of Betel Quid Constituents with Drug Disposition Pathways: An Overview	14
Potential Alteration of Rifampicin’s Bioavailability by Phyllanthus niruri Supplementation in Tuberculosis Therapy	14
ADMET Profiling in Drug Discovery and Development: Perspectives of In Silico, In Vitro and Integrated Approaches	14
Tacrolimus, Cytochrome P450, Interactions with Food Variables in Organ Transplant Recipients; A Current and Comprehensive Review	13
Urine Metabolites as a Predictor of Warfarin Response Based on INR in Atrial Fibrillation	13
Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review	13
Rapid Profiling of the Marker Components in Artemisia annua L. and their Metabolites in Rats Using an Improved Liquid Chromatography-tandem Highresolution Mass Spectrometry-based Technology	12
Regulation of Gut Microbiota by Herbal Medicines	12
Influence of Zhuanggu Guanjie Pill on Seven Cytochrome P450 Enzymes Based on Probe Cocktail and Pharmacokinetics Approaches	12
Meet the Associate Editor	11
Inhibition of Glycyrrhiza Polysaccharide on Human Cytochrome P450 46A1 in vitro and in vivo: Implications in Treating Neurological Diseases	11

Nucleic Acid Nanomaterials: Biostability and Applications	10
Meet the Associate Editorial Board Member	10
WITHDRAWN: Pharmacokinetic Drug Interactions of Piperine: A Review of Pre-clinical and Clinical Studies	10
Comparative Analysis of Machine Learning Algorithms Evaluating the Single Nucleotide Polymorphisms of Metabolizing Enzymes with Clinical Outcomes Following Intravenous Paracetamol in Preterm Neonates	10
The Impacts and Changes Related to the Cancer Drug Resistance Mechanism	10
Meet the Associate Editor	9
Suppression of Melanoma Growth in a Murine Tumour Model Using Orthosiphon stamineus Benth. Extract Loaded in Ethanolic Phospholipid Vesicles (Spherosome)	9
Pharmacokinetic Interaction between Imatinib and Tacrolimus in Rats	9
Role of Cytochrome P450 3A4 in Cancer Drug Resistance: Challenges and Opportunities	9
Relevance of ABC Transporters in Drug Development	8
The Effect of Coenzyme Q10 as a Part of Standard Therapy on Plasma Concentrations of Ubiquinol, Ubiquinone, Total CoQ10 and its Redox State in Patients with Ischemic Heart Disease	8
Meet the Editorial Board Member	8
Evaluation of Supervised Machine Learning Algorithms and Computational Structural Validation of Single Nucleotide Polymorphisms Related to Acute Liver Injury with Paracetamol	8
Rapid and Comprehensive Identification of Vincosamide Metabolites in vitro and in vivo in Rats by Ultra-High Performance Liquid Chromatography-Quadrupole- Exactive Orbitrap-High Resolution Mass Spectr	8
Circadian Timekeeping in Anticancer Therapeutics: An Emerging Vista of Chronopharmacology Research	8
The Magic of Drug Targeting Is “Secretly” Tied to Optimal Drug Distribution and Exposure	8
Investigating the Metabolic Mechanisms of Butaselen, An Ebselen Analog	7
Comparative Analysis of Pharmacokinetics and Metabolites of Three Main Terpenoids before and after Compatibility of Frankincense and Myrrh in Rats by UHPLC-MS	7
Meet the Editorial Board Member	7
Meet the Editorial Board Member	7
Genetic Testing is Superior Over Endogenous Pharmacometabolomic Markers to Predict Safety of Haloperidol in Patients with Alcohol-induced Psychotic Disorder	7
Worldwide Prevalence of Polypharmacy: A Systematic Review	7
Influence of Orange Oil on Skin Permeability, Dermatokinetics, and In Vivo Anti-inflammatory Properties of Lornoxicam-loaded Niosomal Gel	7
Association of UGT1A Gene Polymorphisms with BKV Infection in Renal Transplantation Recipients	7
Corrigendum To: Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates	7
The Metabolic Pathways and Products of Ten Aconitum Alkaloids in Sanwujiao Pills from Eight Organs of Mice by UHPLC-Q-TOF-MS/MS	7
Nanostructured Therapeutic Systems of PUFAs for the Treatment of Glioblastoma Multiforme	6
In vivo Metabolism of Nifurtimox and the Drug-Drug Interaction Potential Including its Major Metabolites	6
A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look	6
Comparative In Vitro Metabolic Profile Study of Five Cathinone Derivatives	6
Influence of CYP2C9 Polymorphisms on Plasma Concentration of Warfarin and 7-Hydroxy Warfarin in South Indian Patients	6
Effects of Fasting andPhoenix dactyliferaon the Expression of Major Drug- Metabolizing Enzymes in the Mouse Livers	6
Effect of Dexketoprofen on the Disposition Kinetics of Moxifloxacin in Plasma and Lung in Male and Female Rats	6
The Impact of Certain Pharmacogenetic Differences on the Metabolism of Antiretroviral Drugs Used in A Black South African Population	6
Drug Metabolizing Enzymes: An Exclusive Guide into Latest Research in Pharmaco-genetic Dynamics in Arab Countries	6
Lingguizhugan Decoction Improved Obesity by Modulating the Gut Microbiota and its Metabolites in Mice	6
Research Progress of Epigenetic Modification on the Regulation of Transporters Under Hypoxia	6
Hydrogen Peroxide Induces Ethanol-inducible CYP2E1 via the NF-kB-classical Pathway: CYP2E1 mRNA Levels are not High in Alcoholic Hepatitis	6
Comprehensive Metabolism Study of Tangeretin in Rat Plasma, Urine and Faeces Using Ultra-High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole- Orbitrap High-Resolution Accurate Mass Spe	5
Exploring Drug-Drug Interactions between Losartan and Carbamazepine: A Pharmacokinetic and Pharmacodynamic Study	5
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines	5
Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction	5
The Development of a Physiologically Based Pharmacokinetic (PBPK) Model of Andrographolide in Mice and Scaling it up to Rats, Dogs, and Humans	5
Gut Microbiota as the Potential Mechanism to Mediate Drug Metabolism Under High-altitude Hypoxia	5
Study on the Relationship between Rivaroxaban and Factor Xa Activity in Blood Based on HPLC-MS/MS	5
Evaluation of Alterations in DNA Methylation of CYP3A4 Gene Upstream Regulatory Elements in Gastric Cancer and in Response to Diazinon Treatment	5
Cabozantinib Carries the Risk of Drug-Drug Interactions via Inhibition of UDPglucuronosyltransferase (UGT) 1A9	5
An Efficient Integrated Strategy for Comprehensive Metabolite Profiling of Sakurasosaponin from Aegiceras corniculatum in Rats	5
miRNAs in SARS-CoV-2 Infection: An Update	5
Pharmacokinetics and Tissue Distribution of Isovitexin-2''-O-β-D-glucopyranoside (IVG) in Sprague-Dawley Rats	5

Meet the Co-Editor	5
Pharmacokinetic/Pharmacodynamic Study of Salt-Processed Product of Cuscutae Semen with Hepatoprotective Effects	5
The Application of Artificial Intelligence in Drug ADME Research	5
Quality by Design Approach for the Development of Cariprazine Hydrochloride Loaded Lipid-Based Formulation for Brain Delivery via Intranasal Route	5
Machine Learning in Drug Metabolism Study	5
Various Aspects of Fasting on the Biodistribution of Radiopharmaceuticals	5
Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates	5
Additive Manufacturing and Printing Approaches for the Development of Pharmaceutical Dosage Forms with Improved Biopharmaceutical Attributes	5
The Application of Nucleic Acid Nanomaterials in the Treatment of Mitochondrial Dysfunction	5
Orchestration of Obesolytic Activity of Microbiome: Metabiotics at Centre Stage	5
Meet the Regional Editor	4
Effects of CYP2B6 Genetic Variants on the Propofol Dose and Response among Jordanian Arabic Patients Undergoing General Anesthesia	4
Quality by Design-Steered Development of Stealth Liposomal Formulation of Everolimus: A Systematic Optimization and Evaluation	4
Effect of Wuzhi Capsule (WZC) on the Pharmacokinetics of Tacrolimus in Renal Transplantation Recipients	4
Meet the Editorial Board Member	4
Hepatic Effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, the Signature Component of Traditional Chinese Medicine Heshouwu: Advances and Prospects	4
Anticancer Activity and In Silico ADMET Properties of 2,4,5-Trisubstitutedthiazole Derivatives	4
DNA-based Nanomaterials in the Immunotherapy	4
Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model	4
Unraveling the Role of COMT Polymorphism in Dopamine-Mediated Vasopressor Effects: An Observational Cross-Sectional Study	4
Comprehensive Insights into Licochalcone A: its Distribution, Biosynthesis, Metabolism, and Pharmacological Effects	4
Metabolite Identification in the Preclinical and Clinical Phase of Drug Development	4
Impact of Drug Metabolism/Pharmacokinetics and its Relevance Considering Traditional Medicine-based Anti-COVID-19 Drug Research	4
Effect of Salbutamol on the Disposition Kinetics of Levofloxacin in the Plasma and Lung of Rats	4
Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update	4
Umbelliferone Enhances Immune Function in Cyclophosphamide-Induced Immunosuppressed Mice via Histidine and Purine Metabolism Regulation	4
Impact of POR*28 Variant on Tacrolimus Pharmacokinetics in Kidney Transplant Patients with Different CYP3A5 Genotypes	4
In Silico Tools to Thaw the Complexity of the Data: Revolutionizing Drug Research in Drug Metabolism, Pharmacokinetics and Toxicity Prediction	4
Nutritional Therapy Strategies Targeting Tumor Energy Metabolism	4
Acknowledgement to Reviewers	4
Nanotechnological Approaches for the Treatment of Triple-Negative Breast Cancer: A Comprehensive Review	4
Pain Allaying Epalrestat-Loaded Lipid Nanoformulation for the Diabetic Neuropathic Pain Interventions: Design, Development, and Animal Study	3
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPARγ, and TGF-β/Smad Pathways in Mice	3
Inhibition of Cytochrome P450 Enzyme and Drug-Drug Interaction Potential of Acid Reducing Agents Used in Management of CDK Inhibitors for Breast Cancer Chemotherapy	3
A Phase I Clinical Study of the Pharmacokinetics and Safety of Prusogliptin Tablets in Subjects with Mild to Moderate Hepatic Insufficiency and Normal Liver Function	3
Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like Factor 9 (KLF9)	3
Metabolic Pathway of Osilodrostat in Equine Urine Established through High-resolution Mass Spectrometric Characterization for Doping Control	3
The Metabolism of the New Benzodiazepine Remimazolam	3
Meet the Editorial Board Member	3
Framework Nucleic Acids: A Promising Vehicle for Small Molecular Cargos	3
Pharmacokinetic Drug-Drug Interactions Involving Antiretroviral Agents: An Update	3
Differential Pharmacokinetic Interplay of Atorvastatin on Lacosamide and Levetiracetam on Experimental Convulsions in Mice	3
Development and Validation of a Sensitive UPLC-Q-TOF-MS/MS for the Measurement of Nine Components in Rat Plasma and Tissues and its Application to Pharmacokinetics and Tissue Distribution Studies with	3
Design and Construction of Carboxylesterase 2c Gene Knockout Rats by CRISPR/Cas9	3
Meropenem for the Pharmacological Treatment of Severe Infections in Critically Ill Pediatric Patients: Breakthrough Standard Treatment Strategies Based on PK/PD	3
Comprehensive Investigation of the Influence of High-Altitude Hypoxia on Clopidogrel Metabolism and Gut Microbiota	3
Elevated Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Predict Drug-Induced Acute Kidney Injury	2
Hepatic Metabolic Enzyme Activity with Endogenous Substances-Current Status, Challenges and Limitations	2
Comparative Pharmacokinetics of Intravenous Enrofloxacin in One- Six- And Twelve-Month-Old Sheep	2
Meet the Editorial Board Member	2
Meet the Editorial Board Member	2
Effective Cancer Management: Inimitable Role of Phytochemical Based Nano- Formulations	2
Meet the Associate Editor	2
Study on Cytochrome P450 Metabolic Profile of Paclitaxel on Rats using QTOF-MS	2
Bioactive Herbs for Liver Disorders: A Phyto-Pharmacological Review	2
In-vitro and In-vivo Identification, Absorbtion and Metabolism Network Analysis of Filifolium sibiricum Flavonoids Dropping Pill by UHPLC-Q-TOF-MS	2
Simultaneous Method Development and Validation of Anastrozole Along with Piperine: Degradation Studies and Degradants Characterization Using LC-QTOF-ESI-MS Along with In-silico ADMET Prediction	2
Pharmacokinetics-based Chronotherapy	2
A Comparative Study on Sedation Efficacy Between General and Regional Anesthesia with Dexmedetomidine in Patients Under Maxillofacial Surgery	2
Advances in Controlled Release Formulations for Ocular Diseases: Improving Patient Compliance and Therapeutic Outcomes	2
Thymoquinone Lipid Nanoparticles Cut the Gordian Knots of Depression via Neuroprotective BDNF and Downregulation of Neuro-inflammatory NF-κB, IL-6, and TNF-α in LPS Treated Rats	2
Review of the Clinical Pharmacokinetics, Efficacy and Safety of Pembrolizumab	2
Meet the Associate Editor	2
Medicinal Plants and Natural Products: More Effective and Safer Pharmacological Treatment for the Management of Obesity	2
Meet the Editorial Board Member	2
UPLC-LTQ-Orbitrap Study on Rat Urinary Metabolites of 5-Methoxy-Alpha-Methyltryptamine	2
Amino Acid and Biogenic Amine Adductions Derived from Reactive Metabolites	2
Factors Influencing ADME Properties Of Drugs: Advances and Applications (Part II)	2
Comparative Pharmacokinetics of Scoparone and its Metabolite Scopoletin in Normal and ANIT-induced Intrahepatic Cholestatic Rats	2
Nanomedicine for Cancer: Targeted Therapy, Vaccination, Pharmacokinetics, and Challenges	2
Effect of C. cyminum and L. sativum on Pharmacokinetics and Pharmacodynamics of Antidiabetic Drug Gliclazide	2
Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery	2
Comparative Study of Binding Pockets in Human CYP1A2, CYP3A4, CYP3A5, and CYP3A7 with Aflatoxin B1, a Hepato-Carcinogen, by Molecular Dynamics Simulation & Principal Component Analysis	2
Approaches to Address PK-PD Challenges of Conventional Liposome Formulation with Special Reference to Cancer, Alzheimer's, Diabetes, and Glaucoma: An Update on Modified Liposomal Drug Delivery System	2
Characterization of Dicaffeoylspermidine Derivatives from Wolfberry as Potent and Selective Inhibitors of Human Cytochrome P450 46A1 In vitro	2
Biomimetic Nanoscale Systems for Targeted Delivery in Cancer: Current Advances and Future Prospects	2
Rapid Chemical Profiling of Compound Huanggen Granules and Absorbed Prototypes in Cynomolgus Monkey Plasma by Integrating UHPLC-Q-TOF-MSE Method and Data Post-Processing Strategy	2
Fluoropyrimidine Toxicity: the Hidden Secrets of DPYD	2
Recent Advances in Novel Recombinant RNAs for Studying Post-transcriptional Gene Regulation in Drug Metabolism and Disposition	2
m6A Modified-CYP1B1 Promotes HCC Cell Proliferation by Inhibiting Ferroptosis	2

Synthesis and Antimicrobial Activity of Silver/Copper Oxide/Clay Hybrid Nanocomposites Against Gram-Positive and Gram-Negative Bacteria	2
Interaction of Intestinal Microbiota with Medications	2
A Review on Drug-Metabolizing Enzymes, Transporters, and Gut Microbiota on Pharmacokinetics in High-Altitude Environment	1
A Randomized Trial of Short-term Treatment with Folic Acid to Reduce the Oxidative Stress of Patients with Chronic Kidney Disease	1
Unexpected Clinically Significant Drug-Drug Interaction between Tacrolimus and Metronidazole in the Early Period after Renal Transplantation: A Literature Review	1
Where is the Study of mRNA Vaccine Disposition?	1
Emerging Trends in Hybrid Nanoparticles: Revolutionary Advances and Promising Biomedical Applications	1
Meet the Editorial Board Member	1
Temperature-sensitive Hydrogel: An Effective Treatment for Nasal Drug Delivery Targeting the Brain	1
Aceclofenac-Loaded Microspheres Prepared by Vesicular Ionotropic Gelation to Minimize Drug-induced Gastric Ulcers in Rats	1
Effect of Carbonized Herba schizonepetae on the Bioavailability of Eight Active Components from Pulsatillae Decoction in its Particular Adsorption and Release Performance	1
The Promising Role of Natural Exosomal Nanoparticles in Cancer Chemoimmunotherapy	1
Influence of SLCO1B1 Polymorphisms on the Pharmacokinetics of Mycophenolic Acid in Renal Transplant Recipients	1
Meet the Editorial Board Member	1
No Effect of PXR (8055C>T) Polymorphism on the Pharmacokinetic Profiles of Piperaquine in Healthy Chinese Subjects	1
Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic	1
A Combination of Magnoflorine and Spinosin Improves the Antidepressant effects on CUMS Mouse Model	1
Physiologically Based Pharmacokinetic Model for Older Adults and Its Application in Geriatric Drug Research	1
Acknowledgements to Reviewers	1
WITHDRAWN: Pharmaceutical Nanoemulsion System: A Strategy to Enhance the Bioavailability of Drugs	1
Disposition Kinetics of Cathinone and its Metabolites after Oral Administration in Rats	1
Meet the Editorial Board Member	1
Acknowledgement to Reviewers	1
An Overview of the Neuropharmacological Potential of Thymoquinone and its Targeted Delivery Prospects for CNS Disorder	1
Phytofabricated Nanoparticle Formulation for Cancer Treatment: A Comprehensive Review	1
Metabolic Stability and Metabolite Identification of CYP450 Probe Substrates in Ferret Hepatocytes	1
Development in Drug Metabolite Profiling (Part-I)	1
Comparative Analysis of the Gelsemium Alkaloids Metabolism in Human, Pig, Goat, and Rat Liver Microsomes	1
A Mini-review on Recent Strategies and Applications of Nanomedicines to Combat Antimicrobial Resistance	1
Biopharmaceutical Factors Involved in the Disposition of Mycophenolic Acid: A Comprehensive Review of ADME Properties and Their Potential Impact on Mycophenolic Acid Plasma Exposure	1
Herbal Medicines as Adjuvants for the Treatment of Chemotherapy-Induced Diarrhea	1
Emerging Approaches in Data-Driven Drug Discovery for Rare Diseases	1
Ceftobiprole and Cefiderocol for Patients on Extracorporeal Membrane Oxygenation: The Role of Therapeutic Drug Monitoring	1
Drug-Protein Interactions Prediction Models Using Feature Selection and Classification Techniques	1
A Cross-sectional Comparative Analysis of Eleven Population Pharmacokinetic Models for Docetaxel in Chinese Breast Cancer Patients	1
Vitamin D Metabolism Gene Polymorphisms and Their Associated Disorders: A Literature Review	1
Classical and Machine Learning Methods for Protein - Ligand Binding Free Energy Estimation	1
Effects of Shenmai Injection on the Pharmacokinetics of Dasatinib: An In-Depth In vivo Analysis Utilizing UPLC-MS/MS Technique	1
Evaluation of Intracellular Metabolism of Methotrexate in Hepatocytes and Embryonic Kidney Cells based on Folylpolyglutamate Synthetase and Gamma-Glutamyl Hydrolase Expression	1
Effect of Atorvastatin on Single Oral Pharmacokinetics and Safety of Daclatasvir in Rats: Emphasis on P-glycoprotein and Cytochrome P450	1
Targeting the Pathological Hallmarks of Alzheimer’s Disease Through Nanovesicleaided Drug Delivery Approach	1
State-of-the-art Application of Artificial Intelligence to Transporter-centered Functional and Pharmaceutical Research	1
Characterization of Five Natural Anthraquinone Compounds as Potent Inhibitors against CYP1B1: Implications for Cancer Treatment	1
Where will Medicines that Serve the Global South and Economically Disadvantaged People Come From?	1
A Data Mining Approach on Polypharmacy and Drug-drug Interactions of Common Diabetes Medications	1
Artificial Intelligence in Drug Formulation and Development: Applications and Future Prospects	1
Comprehensive Analysis of Chemical Ingredients of Waiganfengsha Granule and Absorbed Components in Rat Plasma Based on UHPLC-Q-TOF-MS	1
Identification of the Metabolites of Scutebarbatine A in Rat Plasma, Bile, Urine, and feces by Using Ultra-high-performance Liquid Chromatography Coupled with Q Exactive Hybrid Quadrupole-orbitrap Hig	1
Unveiling the Interplay: Antioxidant Enzyme Polymorphisms and Oxidative Stress in Preterm Neonatal Renal and Hepatic Functions	1
Physiologically-Based Pharmacokinetic Modeling of Tenofovir Disoproxil Fumarate in Pregnant Women	1