Current Drug Metabolism

Article	Citations
Novel Techniques and Models for Studying Drug Metabolism and Transport	38
Potential Alteration of Rifampicin’s Bioavailability by Phyllanthus niruri Supplementation in Tuberculosis Therapy	37
Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery	34
Targeting Metabolic Dysregulation in Alzheimer’s Disease: A Potential Therapeutic Strategy	22
In vitro and In vivo Drug Metabolism Analysis of BPI-460372 - A Covalent TEAD1/3/4 Inhibitor	21
Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic Receptor Blocker, 101BHG-D01, in Dogs and Rats	17
Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Polygonatum sibiricum Polysaccharide on Type 2 Diabetes Mellitus Model Rats	16
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke	16
HFD-induced Alterations in Renal Tubular Oatp4c1-P-gp Transport Systems in Mice: Impact on Digoxin Renal Excretion and Gadolinium-Enhanced Radiological Manifestations	16
The Influences and Mechanisms of High-altitude Hypoxia Exposure on Drug Metabolism	16
Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme	15
Interactions of Betel Quid Constituents with Drug Disposition Pathways: An Overview	14
Theoretical Evaluation of Oleocanthal Reactive Centers	14
Network Pharmacology and Metabolomics to Uncover the Multi-Target Anti-Non-Small Cell Lung Cancer Mechanism of Baicalin Mediated by Purine Metabolism	13
Tacrolimus, Cytochrome P450, Interactions with Food Variables in Organ Transplant Recipients; A Current and Comprehensive Review	13
Meet the Section Editor	13
Regulation of Gut Microbiota by Herbal Medicines	13
Nucleic Acid Nanomaterials: Biostability and Applications	12
Meet the Associate Editorial Board Member	12
Meet the Associate Editor	12
Comparative Analysis of Machine Learning Algorithms Evaluating the Single Nucleotide Polymorphisms of Metabolizing Enzymes with Clinical Outcomes Following Intravenous Paracetamol in Preterm Neonates	11
Acknowledgements to Reviewers	11
WITHDRAWN: Pharmacokinetic Drug Interactions of Piperine: A Review of Pre-clinical and Clinical Studies	11
Influence of Zhuanggu Guanjie Pill on Seven Cytochrome P450 Enzymes Based on Probe Cocktail and Pharmacokinetics Approaches	11
The Impacts and Changes Related to the Cancer Drug Resistance Mechanism	11

Rapid and Comprehensive Identification of Vincosamide Metabolites in vitro and in vivo in Rats by Ultra-high Performance Liquid Chromatography-Quadrupole-Exactive Orbitrap-high Resolution Mass Spectro	10
Inhibition of Glycyrrhiza Polysaccharide on Human Cytochrome P450 46A1 in vitro and in vivo: Implications in Treating Neurological Diseases	10
The Effect of Coenzyme Q10 as a Part of Standard Therapy on Plasma Concentrations of Ubiquinol, Ubiquinone, Total CoQ10 and its Redox State in Patients with Ischemic Heart Disease	10
The Magic of Drug Targeting Is “Secretly” Tied to Optimal Drug Distribution and Exposure	10
Role of Cytochrome P450 3A4 in Cancer Drug Resistance: Challenges and Opportunities	10
Development of Transdermal Drug Delivery Approaches to Combat Diabetes: An Update	10
Meet the Associate Editor	10
Evaluation of Supervised Machine Learning Algorithms and Computational Structural Validation of Single Nucleotide Polymorphisms Related to Acute Liver Injury with Paracetamol	9
Pharmacokinetic Interaction between Imatinib and Tacrolimus in Rats	9
Meet the Editorial Board Member	9
Relevance of ABC Transporters in Drug Development	9
Strain Evaluation and Multi-Generational Stability of Cordyceps militaris for Functional Bioactive Compound Production	9
Association of UGT1A Gene Polymorphisms with BKV Infection in Renal Transplantation Recipients	8
Genetic Testing is Superior Over Endogenous Pharmacometabolomic Markers to Predict Safety of Haloperidol in Patients with Alcohol-induced Psychotic Disorder	8
Corrigendum To: Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates	8
Investigating the Metabolic Mechanisms of Butaselen, An Ebselen Analog	8
Comparative Analysis of Pharmacokinetics and Metabolites of Three Main Terpenoids before and after Compatibility of Frankincense and Myrrh in Rats by UHPLC-MS	8
Deciphering the Impact of Protein Corona on Biological Fate of Nanomedicine-Loaded Microneedles	7
Worldwide Prevalence of Polypharmacy: A Systematic Review	7
Research Progress of Epigenetic Modification on the Regulation of Transporters Under Hypoxia	7
The Metabolic Pathways and Products of Ten Aconitum Alkaloids in Sanwujiao Pills from Eight Organs of Mice by UHPLC-Q-TOF-MS/MS	7
Lingguizhugan Decoction Improved Obesity by Modulating the Gut Microbiota and its Metabolites in Mice	7
Meet the Editorial Board Member	7
Influence of Orange Oil on Skin Permeability, Dermatokinetics, and In Vivo Anti-inflammatory Properties of Lornoxicam-loaded Niosomal Gel	7
Effect of Dexketoprofen on the Disposition Kinetics of Moxifloxacin in Plasma and Lung in Male and Female Rats	7
Hydrogen Peroxide Induces Ethanol-inducible CYP2E1 via the NF-kB-classical Pathway: CYP2E1 mRNA Levels are not High in Alcoholic Hepatitis	6
Comparative In Vitro Metabolic Profile Study of Five Cathinone Derivatives	6
The Impact of Certain Pharmacogenetic Differences on the Metabolism of Antiretroviral Drugs Used in A Black South African Population	6
The Application of Nucleic Acid Nanomaterials in the Treatment of Mitochondrial Dysfunction	6
Additive Manufacturing and Printing Approaches for the Development of Pharmaceutical Dosage Forms with Improved Biopharmaceutical Attributes	6
In vivo Metabolism of Nifurtimox and the Drug-Drug Interaction Potential Including its Major Metabolites	6
Natural Compounds as Potential Therapeutics for Pancreatic Cancer: A Narrative Review	6
Pharmacokinetic/Pharmacodynamic Study of Salt-Processed Product of Cuscutae Semen with Hepatoprotective Effects	6
Comparative Proteomics of Hepatocytes And Hepatic Cell Lines Using Swath-MS Reveals Significant Variations In Proteins Involved In Energy, Lipid, And Xenobiotic Metabolism	6
The Application of Artificial Intelligence in Drug ADME Research	6
Drug Metabolizing Enzymes: An Exclusive Guide into Latest Research in Pharmaco-genetic Dynamics in Arab Countries	6
Effects of Fasting andPhoenix dactyliferaon the Expression of Major Drug- Metabolizing Enzymes in the Mouse Livers	6
In Vitro Drug–Drug Interactions between Oxycodone and Commonly Co-Consumed Drugs in Rat and Human Liver Microsomes	6
Meet the Co-Editor	6
A Unifying Perspective in Blunting the Limited Oral Bioavailability of Curcumin: A Succinct Look	6
The Development of a Physiologically Based Pharmacokinetic (PBPK) Model of Andrographolide in Mice and Scaling it up to Rats, Dogs, and Humans	5
The Multifaceted Role of Cytochrome P450 Isoenzymes in Alcoholic and Metabolic (Dysfunction) Fatty Liver Diseases	5
Various Aspects of Fasting on the Biodistribution of Radiopharmaceuticals	5
Effects of CYP2B6 Genetic Variants on the Propofol Dose and Response among Jordanian Arabic Patients Undergoing General Anesthesia	5
Application of Physiologically Based Pharmacokinetic Modeling in the Research of Anti-HIV Drugs	5
Machine Learning in Drug Metabolism Study	5
LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines	5
Exploring Drug-Drug Interactions between Losartan and Carbamazepine: A Pharmacokinetic and Pharmacodynamic Study	5
Pharmacokinetics and Tissue Distribution of Isovitexin-2''-O-β-D-glucopyranoside (IVG) in Sprague-Dawley Rats	5
Comprehensive Metabolism Study of Tangeretin in Rat Plasma, Urine and Faeces Using Ultra-High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole- Orbitrap High-Resolution Accurate Mass Spe	5

Cabozantinib Carries the Risk of Drug-Drug Interactions via Inhibition of UDPglucuronosyltransferase (UGT) 1A9	5
An Efficient Integrated Strategy for Comprehensive Metabolite Profiling of Sakurasosaponin from Aegiceras corniculatum in Rats	5
Meet the Regional Editor	4
Umbelliferone Enhances Immune Function in Cyclophosphamide-Induced Immunosuppressed Mice via Histidine and Purine Metabolism Regulation	4
In Silico Tools to Thaw the Complexity of the Data: Revolutionizing Drug Research in Drug Metabolism, Pharmacokinetics and Toxicity Prediction	4
Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update	4
Unraveling the Role of COMT Polymorphism in Dopamine-Mediated Vasopressor Effects: An Observational Cross-Sectional Study	4
DNA-based Nanomaterials in the Immunotherapy	4
Effect of Wuzhi Capsule (WZC) on the Pharmacokinetics of Tacrolimus in Renal Transplantation Recipients	4
Quality by Design Approach for the Development of Cariprazine Hydrochloride Loaded Lipid-Based Formulation for Brain Delivery via Intranasal Route	4
Nutritional Therapy Strategies Targeting Tumor Energy Metabolism	4
Comprehensive Insights into Licochalcone A: its Distribution, Biosynthesis, Metabolism, and Pharmacological Effects	4
Effect of C. cyminum and L. sativum on Pharmacokinetics and Pharmacodynamics of Antidiabetic Drug Gliclazide	3
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPARγ, and TGF-β/Smad Pathways in Mice	3
Pharmacological Complexities of Herbal Medicinal Extracts: A Review of Bioavaila-bility, Interactions, and Standardization	3
Quality by Design-Steered Development of Stealth Liposomal Formulation of Everolimus: A Systematic Optimization and Evaluation	3
Acknowledgement to Reviewers	3
Pain Allaying Epalrestat-Loaded Lipid Nanoformulation for the Diabetic Neuropathic Pain Interventions: Design, Development, and Animal Study	3
Advances in Controlled Release Formulations for Ocular Diseases: Improving Patient Compliance and Therapeutic Outcomes	3
Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like Factor 9 (KLF9)	3
Mass Balance and Metabolic Profiling of Avacopan, a Selective C5a Receptor 1 Antagonist, in Healthy Humans	3
Transcriptomic and Proteomics Analysis of a Lipid-Loaded HepaRG Model for Steatosis Reveals Altered Regulation in Lipid and Xenobiotic Metabolism	3
The Metabolism of the New Benzodiazepine Remimazolam	3
An Explicative Review on Nanotechnology-based Drug Delivery Systems for Alleviating Oxidative Stress-driven Pathologies	3
Hepatic Effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, the Signature Component of Traditional Chinese Medicine Heshouwu: Advances and Prospects	3
Nanotechnological Approaches for the Treatment of Triple-Negative Breast Cancer: A Comprehensive Review	3
Framework Nucleic Acids: A Promising Vehicle for Small Molecular Cargos	3
Metabolic Pathway of Osilodrostat in Equine Urine Established through High-resolution Mass Spectrometric Characterization for Doping Control	3
Meropenem for the Pharmacological Treatment of Severe Infections in Critically Ill Pediatric Patients: Breakthrough Standard Treatment Strategies Based on PK/PD	3
A Phase I Clinical Study of the Pharmacokinetics and Safety of Prusogliptin Tablets in Subjects with Mild to Moderate Hepatic Insufficiency and Normal Liver Function	3
Emerging Nanoformulation-Based Carrier Systems: New Insights into Promising Vaccine Delivery	3
Differential Pharmacokinetic Interplay of Atorvastatin on Lacosamide and Levetiracetam on Experimental Convulsions in Mice	3
Effect of Salbutamol on the Disposition Kinetics of Levofloxacin in the Plasma and Lung of Rats	3
Lung-Targeting Cepharanthine Polymer Micelles Modified with Mannose: Effectiveness against Acute Lung Injury Evaluated Using in vitro and in vivo Analyses	3
Design and Construction of Carboxylesterase 2c Gene Knockout Rats by CRISPR/Cas9	3
Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery	3
Comparative Study of Binding Pockets in Human CYP1A2, CYP3A4, CYP3A5, and CYP3A7 with Aflatoxin B1, a Hepato-Carcinogen, by Molecular Dynamics Simulation & Principal Component Analysis	3
Comprehensive Investigation of the Influence of High-Altitude Hypoxia on Clopidogrel Metabolism and Gut Microbiota	3
Physiologically Based Pharmacokinetic Model for Older Adults and Its Application in Geriatric Drug Research	2
Meet the Editorial Board Member	2
Recent Advances in Novel Recombinant RNAs for Studying Post-transcriptional Gene Regulation in Drug Metabolism and Disposition	2
Approaches to Address PK-PD Challenges of Conventional Liposome Formulation with Special Reference to Cancer, Alzheimer's, Diabetes, and Glaucoma: An Update on Modified Liposomal Drug Delivery System	2
Comparative Pharmacokinetics of Scoparone and its Metabolite Scopoletin in Normal and ANIT-induced Intrahepatic Cholestatic Rats	2
TOX4 Inhibition in Chronic Hyperglycemia: Effects on Glycation Stress, Hepatic Protection, Epigenetic Mechanisms, Signaling Pathways, and Beta Cell Dynamics	2
Fluoropyrimidine Toxicity: the Hidden Secrets of DPYD	2
In-vitro and In-vivo Identification, Absorbtion and Metabolism Network Analysis of Filifolium sibiricum Flavonoids Dropping Pill by UHPLC-Q-TOF-MS	2
Study on Cytochrome P450 Metabolic Profile of Paclitaxel on Rats using QTOF-MS	2
Shenfu Decoction Extends Survival Time of Seawater-Induced Hypothermia in Rats: The Role of Metabolomics and Gut Microbiota	2
Biomimetic Nanoscale Systems for Targeted Delivery in Cancer: Current Advances and Future Prospects	2
Constant-Speed Intravenous Infusion Model Determines Pharmacokinetic Parameters: Phylloquinone as an Example	2
UPLC-LTQ-Orbitrap Study on Rat Urinary Metabolites of 5-Methoxy-Alpha-Methyltryptamine	2
Factors Influencing ADME Properties Of Drugs: Advances and Applications (Part II)	2
Nanomedicine for Cancer: Targeted Therapy, Vaccination, Pharmacokinetics, and Challenges	2
A Comparative Study on Sedation Efficacy Between General and Regional Anesthesia with Dexmedetomidine in Patients Under Maxillofacial Surgery	2
Pharmacokinetic Drug-Drug Interactions Involving Antiretroviral Agents: An Update	2
Review of the Clinical Pharmacokinetics, Efficacy and Safety of Pembrolizumab	2
Effective Cancer Management: Inimitable Role of Phytochemical Based Nano- Formulations	2
Physiologically-Based Pharmacokinetic Modeling of Tenofovir Disoproxil Fumarate in Pregnant Women	2
Meet the Associate Editor	2
Advances in Nanomedicine: Transforming Diagnostic Imaging with Novel Contrast Agents	2
Bioactive Herbs for Liver Disorders: A Phyto-Pharmacological Review	2
Hepatic Metabolic Enzyme Activity with Endogenous Substances-Current Status, Challenges and Limitations	2
m 6 A Modified-CYP1B1 Promotes HCC Cell Proliferation by Inhibiting Ferroptosis	2
Comparative Pharmacokinetics of Intravenous Enrofloxacin in One- Six- And Twelve-Month-Old Sheep	2
Interaction of Intestinal Microbiota with Medications	2
Synthesis and Antimicrobial Activity of Silver/Copper Oxide/Clay Hybrid Nanocomposites Against Gram-Positive and Gram-Negative Bacteria	2
A Combination of Magnoflorine and Spinosin Improves the Antidepressant effects on CUMS Mouse Model	2
Transfer of Intravenous Remimazolam into Milk of Lactating Sheep and Uptake by Breast-fed Lambs	1
Characterization of Five Natural Anthraquinone Compounds as Potent Inhibitors against CYP1B1: Implications for Cancer Treatment	1
Comprehensive Analysis of Chemical Ingredients of Waiganfengsha Granule and Absorbed Components in Rat Plasma Based on UHPLC-Q-TOF-MS	1
Phytofabricated Nanoparticle Formulation for Cancer Treatment: A Comprehensive Review	1
Disposition Kinetics of Cathinone and its Metabolites after Oral Administration in Rats	1
Herbal Medicines as Adjuvants for the Treatment of Chemotherapy-Induced Diarrhea	1
Comparative Analysis of the Gelsemium Alkaloids Metabolism in Human, Pig, Goat, and Rat Liver Microsomes	1
A Mini-review on Recent Strategies and Applications of Nanomedicines to Combat Antimicrobial Resistance	1
Effect of Atorvastatin on Single Oral Pharmacokinetics and Safety of Daclatasvir in Rats: Emphasis on P-glycoprotein and Cytochrome P450	1
Rapid Chemical Profiling of Compound Huanggen Granules and Absorbed Prototypes in Cynomolgus Monkey Plasma by Integrating UHPLC-Q-TOF-MSE Method and Data Post-Processing Strategy	1
Characterization of Dicaffeoylspermidine Derivatives from Wolfberry as Potent and Selective Inhibitors of Human Cytochrome P450 46A1 In vitro	1
Acknowledgement to Reviewers	1
Influence of SLCO1B1 Polymorphisms on the Pharmacokinetics of Mycophenolic Acid in Renal Transplant Recipients	1

WITHDRAWN: Pharmaceutical Nanoemulsion System: A Strategy to Enhance the Bioavailability of Drugs	1
An Overview of the Neuropharmacological Potential of Thymoquinone and its Targeted Delivery Prospects for CNS Disorder	1
Meet the Editorial Board Member	1
A Review on Drug-Metabolizing Enzymes, Transporters, and Gut Microbiota on Pharmacokinetics in High-Altitude Environment	1
Emerging Approaches in Data-Driven Drug Discovery for Rare Diseases	1
Metabolic Stability and Metabolite Identification of CYP450 Probe Substrates in Ferret Hepatocytes	1
Biopharmaceutical Factors Involved in the Disposition of Mycophenolic Acid: A Comprehensive Review of ADME Properties and Their Potential Impact on Mycophenolic Acid Plasma Exposure	1
Unveiling the Interplay: Antioxidant Enzyme Polymorphisms and Oxidative Stress in Preterm Neonatal Renal and Hepatic Functions	1
Artificial Intelligence in Drug Formulation and Development: Applications and Future Prospects	1
Where will Medicines that Serve the Global South and Economically Disadvantaged People Come From?	1
Meet the Editorial Board Member	1
A Population Pharmacokinetics Model of Busulfan in Pediatric Patients with Thalassemia Major	1
Mobilising Computational Strategies in Enzyme Inhibition: Reconciling Therapeutic Innovation and Environmental Integrity from Molecular Targets to Ecosystem Disruptors	1
Vitamin D Metabolism Gene Polymorphisms and Their Associated Disorders: A Literature Review	1
Where is the Study of mRNA Vaccine Disposition?	1
Emerging Trends in Hybrid Nanoparticles: Revolutionary Advances and Promising Biomedical Applications	1
Evaluation of Intracellular Metabolism of Methotrexate in Hepatocytes and Embryonic Kidney Cells based on Folylpolyglutamate Synthetase and Gamma-Glutamyl Hydrolase Expression	1
Targeting the Pathological Hallmarks of Alzheimer’s Disease Through Nanovesicleaided Drug Delivery Approach	1
Absorption, Distribution, Metabolism, and Excretion of [14C]MT-8, A Derivative of Procyanidin B3 in Sprague-Dawley Rats	1
A Data Mining Approach on Polypharmacy and Drug-drug Interactions of Common Diabetes Medications	1
State-of-the-art Application of Artificial Intelligence to Transporter-centered Functional and Pharmaceutical Research	1
A Cross-sectional Comparative Analysis of Eleven Population Pharmacokinetic Models for Docetaxel in Chinese Breast Cancer Patients	1
Study on the Mechanism of Anti-Cerebral Ischemia-Reperfusion Injury of Ai Pian Based on Network Pharmacology and Metabolomics	1
Ceftobiprole and Cefiderocol for Patients on Extracorporeal Membrane Oxygenation: The Role of Therapeutic Drug Monitoring	1
Drug-Protein Interactions Prediction Models Using Feature Selection and Classification Techniques	1
Molecular Pathways Involved in Drug-Induced Hepatotoxicity: A Mini Review	1
The Promising Role of Natural Exosomal Nanoparticles in Cancer Chemoimmunotherapy	1
Effect of Aging on Deferasirox Therapy in Transfusion-dependent Patients. A Prospective- Retrospective, Cohort-study	1
A Lack of Studies on the Metabolism and Disposition of Hot Compound Class: Triphenylphosphonium-Conjugated Compounds	1