OOIR: Observatory of International Research

Papers

(The TQCC of Pharmaceutical Biology is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
The complex lipid, SPPCT-800, reduces lung damage, improves pulmonary function and decreases pro-inflammatory cytokines in the murine LPS-induced acute respiratory distress syndrome (ARDS) model	87
XiaoEr LianHuaQinqGan alleviates viral pneumonia in mice infected by influenza A and respiratory syncytial viruses	84
Potential pharmacological quality control markers in the traditional Japanese medicine Hangeshashinto: identifying anti-inflammatory ingredients through a cell-based bioassay and multicomponent analys	74
Flaxseed extract reduces tissue accumulation and enhances urinary excretion of chondroitin sulphate in the rat: a possible new path in substrate reduction therapy for mucopolysaccharidosis	69
Mechanisms of action of Lycium barbarum polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9/CXCL10 pathway	60
Modified Zhibai Dihuang pill alleviated urinary tract infection induced by extended-spectrum β-lactamase Escherichia coli in rats by regulating biofilm formation	55
Effects of Tiaopi Xiezhuo decoction on constipation and gut dysbiosis in patients with peritoneal dialysis	54
Comparative analysis of in vitro immunomodulatory potential of four Gentiana species	54
Lack of pharmacokinetic interaction between derazantinib and naringin in rats	53
Adjuvant potential of Satureja hortensis metabolites with antibiotics against Gram-positive and Gram-negative bacterial strains	45
Protective effect of omega-3 polyunsaturated fatty acids on sepsis via the AMPK/mTOR pathway	42
Baicalin suppress the development of polycystic ovary syndrome via regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axis	40
Dual anti-pseudomonal and resistance-modulatory actions of Sida acuta (Malvaceae) via BamB–OprM targeting: insights from integrated metabolomics, computa	38
Design, evaluation, cytotoxic activity, molecular docking, ADMET analysis, and dynamic simulations and the preparation of new isoxazoles, thiazoles, 1,3-thiazines, and thiazolopyrimidines derived from	36
Integrated pharmacoanalysis, bioinformatics analysis, and experimental validation to identify the ingredients and mechanisms of Xiao-Luo-Wan in uterine fibroids treatment	35
Majoon Ushba alleviated IL-17A sensitized keratinocyte ferroptosis via JAK-2-STAT-3 signaling axis and reversed imiquimod induced psoriasiform inflammation	34
Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology	33
Prevention of ulcerative colitis by Huangqin decoction: reducing the intestinal epithelial cell apoptosis rate through the IFN-γ/JAK/ETS signalling pathway	33
Isoalantolactone suppresses gallbladder cancer progression via inhibiting the ERK signalling pathway	33
Antiproliferative activity, cell-cycle arrest, apoptotic induction and LC-HRMS/MS analyses of extracts from two Linum species	32
Rabdosin B suppresses proliferation of nonsmall cell lung cancer by regulating the SRC/PI3K/AKT signaling pathway	32
Hyaluronic acid-engineered milk extracellular vesicles to target triple negative breast cancer through CD44	32
Yiqi Wenyang decoction protects against the development of atherosclerosis by inhibiting vascular inflammation	31
Chaihu Shugan San promotes gastric motility in rats with functional dyspepsia by regulating Drp-1-mediated ICC mitophagy	30
Icariin restrains NLRP3 inflammasome-mediated Th2 immune responses and ameliorates atopic dermatitis through modulating a novel lncRNA MALAT1/miR-124-3p axis	30

Tongmai Yangxin pill alleviates myocardial no-reflow by activating GPER to regulate HIF-1α signaling and downstream potassium channels	29
Epigallocatechin-3-gallate at the nanoscale: a new strategy for cancer treatment	29
Indigo naturalis as a potential drug in the treatment of ulcerative colitis: a comprehensive review of current evidence	29
Advances in Traditional Chinese Medicine research in diabetic kidney disease treatment	29
A triterpene-enriched natural extract from Eucalyptus tereticornis modulates the expression of genes involved in adipogenesis, lipolysis, and extracellul	28
Alpha-Mangosteen lessens high-fat/high-glucose diet and low-dose streptozotocin induced-hepatic manifestations in the insulin resistance rat model	28
Screening of rosmarinic acid from Salvia miltiorrhizae acting on the novel target TRPC1 based on the ‘homology modelling–virtual screening–molecular docking–affinity ass	28
Network pharmacology identification and in vivo validation of key pharmacological pathways of Qin Jiao for gout and arthritis	28
lncRNA MALAT1-mediated regulation of cholesterol-oxidative stress-iron metabolic dysregulation by paeoniflorin in osteoarthritic chondrocytes	27
Natural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules’ fifth labour	27
Plantamajoside alleviates acute sepsis-induced organ dysfunction through inhibiting the TRAF6/NF-κB axis	27
Ginsenoside Rb1 reduces oxidative/carbonyl stress damage and ameliorates inflammation in the lung of streptozotocin-induced diabetic rats	26
The BCL2/BAX/ROS pathway is involved in the inhibitory effect of astragaloside IV on pyroptosis in human umbilical vein endothelial cells	26
Paeoniflorin suppresses the apoptosis and inflammation of human coronary artery endothelial cells induced by oxidized low-density lipoprotein by regulating the Wnt/β-catenin pathway	26
Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents	26
A comprehensive review of antimalarial medicinal plants used by Tanzanians	26
Liver protective effect of chloroform extract of Bauhinia purpurea leaves is attributed partly to its antioxidant action and the presence of flavonoids	26
Homogeneous Polyporus polysaccharide exerts anti-bladder cancer effects via autophagy induction	26
Chitooligosaccharide prevents vascular endothelial cell apoptosis by attenuation of endoplasmic reticulum stress via suppression of oxidative stress through Nrf2-SOD1 up-regulation	25
Gnetum montanum extract induces apoptosis by inhibiting the activation of AKT in SW480 human colon cancer cells	25
Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats	25
Calycosin plays a protective role in diabetic kidney disease through the regulation of ferroptosis	25
Aaptamine – a dual acetyl – and butyrylcholinesterase inhibitor as potential anti-Alzheimer’s disease agent	24
Effect of Wuzi Yanzong prescription on oligoasthenozoospermia rats based on UPLC-Q-TOF-MS metabolomics	24
Chinese herbal compound Huangqin Qingrechubi capsule reduces lipid metabolism disorder and inflammatory response in gouty arthritis via the LncRNA H19/APN/PI3K/AKT casca	24
Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis	24
Notoginsenoside R1 improves intestinal microvascular functioning in sepsis by targeting Drp1-mediated mitochondrial quality imbalance	24
Curcumin inhibits cerebral ischaemia–reperfusion injury and cell apoptosis in rats through the ERK–CHOP–caspase-11 pathway	23
(±)-Rutacycoumarins A and B: two pairs of unprecedented coumarin enantiomers from the aerial part of Ruta graveolens L. and chemically synthesized	23
Molecular mechanisms underlying Tao-Hong-Si-Wu decoction treating hyperpigmentation based on network pharmacology, Mendelian randomization analysis, and experimental verification	23
An integrated strategy for the comprehensive profiling of the chemical constituents of Aspongopus chinensis using UPLC-QTOF-MS combined with molecular networking	23
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways	23
Resveratrol accelerates wound healing by inducing M2 macrophage polarisation in diabetic mice	23
Cardamonin suppressed the migration, invasion, epithelial mesenchymal transition (EMT) and lung metastasis of colorectal cancer cells by down-regulating ADRB2 expression	23
Therapeutic efficacy and pharmacological mechanism of Bailing capsule on chronic obstructive pulmonary disease: a meta-analysis and network pharmacology	23
Upregulation of claudin‑4 by Chinese traditional medicine Shenfu attenuates lung tissue damage by acute lung injury aggravated by acute gastrointestinal injury	23
Effects of ginkgo leaf tablet on the pharmacokinetics of rosiglitazone in rats and its potential mechanism	23
Characterization of global research trends and prospects on celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F: bibliometric an	23
Hydroethanolic extracts from Bauhinia guianensis : a study on acute toxicity in Zebrafish embryos and adults	22
Combination of puerarin and tanshinone IIA alleviates ischaemic stroke injury in rats via activating the Nrf2/ARE signalling pathway	22
Glucocorticoid receptors involved in ginsenoside compound K ameliorate adjuvant arthritis by inhibiting the glycolysis of fibroblast-like synoviocytes via the NF-κB/HIF-1α pathway	22
Thais savignyi tissue extract: bioactivity, chemical composition, and molecular docking	22
Effect of Er Miao San on peritoneal macrophage polarisation through the miRNA-33/NLRP3 signalling pathway in a rat model of adjuvant arthritis	22
Assessing potential liver injury induced by Polygonum multiflorum using potential biomarkers via targeted sphingolipidomics	21
Preparation, characterization, and anticancer effects of an inclusion complex of coixol with β-cyclodextrin polymers	21
Dolichandrone serrulata flower improves seminal biochemical parameters and proteins in T2DM rats induced by a high-fat diet and streptozotocin	21
Comparative efficacy and safety of Chinese patent medicines as an adjunctive therapy for diabetic peripheral neuropathy: systematic review and network meta-analysis of randomized controlled trials	21
Qiangli Wuhu mixture alleviates LPS-induced pneumonia by inhibiting the TLR4/NF-κB/NLRP3 pathway: a study based on network pharmacology	20
The changes of hepatic bile acid synthesis and transport and bile acids profiles in isopsoralen-induced liver injury C57BL/6J mice	20
Clinical observations and mechanistic insights of traditional Chinese medicine in the management of diabetic retinopathy	20

A scoping review of turmeric adulteration based on data from six continents	20
Treatment with onion bulb extract both prevents and reverses allergic inflammation in a murine model of asthma	19
Bombax ceiba flower extract enhances antioxidant defense and wound healing effects in human keratinocytes and fibroblasts	19
Traditional Chinese medicine for breast cancer treatment: a bibliometric and visualization analysis	19
Cytotoxic effects of extracts obtained from plants of the Oleaceae family: bio-guided isolation and molecular docking of new secoiridoids from Jasminum humile	19
Rongjin Niantong Fang ameliorates cartilage degeneration by regulating the SDF-1/CXCR4-p38MAPK signalling pathway	19
Protective effect of valerian extract capsule (VEC) on ethanol- and indomethacin-induced gastric mucosa injury and ameliorative effect of VEC on gastrointestinal motility disorder	19
Tormentic acid, a triterpenoid isolated from the fruits of Chaenomeles speciose , protected indomethacin-induced gastric mucosal lesion via modulating mi	19
Morroniside ameliorates glucocorticoid-induced osteoporosis and promotes osteoblastogenesis by interacting with sodium-glucose cotransporter 2	18
Prediction of the mechanisms of action of Qutan Huoxue decoction in non-alcoholic steatohepatitis (NASH): a network pharmacology study and experimental validation	18
Exploring the mechanisms of action of Zengye decoction (ZYD) against Sjogren’s syndrome (SS) using network pharmacology and animal experiment	18
Osteoprotective effect of Achyranthes bidentata root extract on osteoporotic rats: a systematic review and meta-analysis	18
Delivery of small interfering RNA through lyophilized natural lipid nanoparticles: effects of natural lipid selection	18
WDJ-S4 , a standardized herbal formula, promotes gastrointestinal motility via modulation of the acetylcholine pathway in a loperamide-induced functional dyspepsia mice	18
Optimization of a sensitive and reliable UPLC-MS/MS method to simultaneously quantify almonertinib and HAS-719 and its application to study the interaction with nicardipine	18
Hepatotoxicity of dietary supplements containing Garcinia gummi-gutta (L.) N. Robson	17
Ginsenoside Rc attenuates myocardial ischaemic injury through antioxidative and anti-inflammatory effects	17
Curcuma longa and Boswellia serrata extract combination for hand osteoarthritis: an open-label pre-post trial	17
Triptolide in renal disorders: dual roles of therapeutic potential and nephrotoxicity: a narrative review	17
Isolation, characterisation and complement fixation activity of acidic polysaccharides from Argemone mexicana used as antimalarials in Mali	17
Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light	17
PI3K/AKT/SERBP-1 pathway regulates Alisma orientalis beverage treatment of atherosclerosis in APOE ^−/− high-fat diet mice	17
Qushi Huayu decoction attenuated hepatic lipid accumulation via JAK2/STAT3/CPT-1A-related fatty acid β-oxidation in mice with non-alcoholic steatohepatitis	17
Overview of current research on traditional Chinese medicine in skin disease treatment: a bibliometric analysis from 2014 to 2024	17
Sinisan ameliorates colonic injury induced by water immersion restraint stress by enhancing intestinal barrier function and the gut microbiota structure	17
Swertia mussotii prevents high-fat diet-induced non-alcoholic fatty liver disease in rats by inhibiting expression the TLR4/MyD88 and the phosphorylation of NF-κB	17
MicroRNAs from Yishen Tongluo formula can repair sperm DNA damage caused by benzo( a )pyrene	16
Kazinol B protects H9c2 cardiomyocytes from hypoxia/reoxygenation-induced cardiac injury by modulating the AKT/AMPK/Nrf2 signalling pathway	16
Mechanism investigation of Duhuo Jisheng pill against rheumatoid arthritis based on a strategy for the integration of network pharmacology, molecular docking andin vivoexperimental verification	16
Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor	16
Ligustrazine inhibits inflammatory response of human endometrial stromal cells through the STAT3/IGF2BP1/RELA axis	16
Protective effects of vitamin D ₃ (cholecalciferol) on vancomycin-induced oxidative nephrotoxic damage in rats	16
Qingyi granules ameliorate severe acute pancreatitis in rats by modulating the gut microbiota and serum metabolic aberrations	16
Biologically active withanolides from Physalis peruviana	16
Diosgenin protects against cationic bovine serum albumin-induced membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via the NF-κB pathway	16