OOIR: Observatory of International Research

Papers

(The TQCC of Drug Resistance Updates is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-09-01 to 2024-09-01.)

Article	Citations
Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance	296
An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment	185
Anticancer drug resistance: An update and perspective	166
Taxanes in cancer treatment: Activity, chemoresistance and its overcoming	160
The role of alternative splicing in cancer: From oncogenesis to drug resistance	147
Antimicrobial peptides for combating drug-resistant bacterial infections	141
Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance	126
Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification	118
Cancer immunotherapy resistance based on immune checkpoints inhibitors: Targets, biomarkers, and remedies	117
Therapeutic strategies to overcome taxane resistance in cancer	116
Hypoxia as a driver of resistance to immunotherapy	116
Novel nanomedicines to overcome cancer multidrug resistance	114
FDA approved drugs with pharmacotherapeutic potential for SARS-CoV-2 (COVID-19) therapy	110
Inhibiting the inhibitors: Targeting anti-apoptotic proteins in cancer and therapy resistance	94
Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses	81
Overcoming cancer chemotherapy resistance by the induction of ferroptosis	79
Nanomedicine to target multidrug resistant tumors	79
Overcoming anti-cancer drug resistance via restoration of tumor suppressor gene function	73
Current therapy and drug resistance in metastatic castration-resistant prostate cancer	68
New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects	67
Research progress of therapeutic effects and drug resistance of immunotherapy based on PD-1/PD-L1 blockade	65
Repurposing old drugs to fight multidrug resistant cancers	63
Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs	63
Long non-coding RNA mediated drug resistance in breast cancer	59
Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine	56

ABC transporters affects tumor immune microenvironment to regulate cancer immunotherapy and multidrug resistance	56
Impact of cancer metabolism on therapy resistance – Clinical implications	54
Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance	53
Overcoming PARPi resistance: Preclinical and clinical evidence in ovarian cancer	52
GSK3β as a novel promising target to overcome chemoresistance in pancreatic cancer	52
Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers	51
Thirty years of VRE in Germany – “expect the unexpected”: The view from the National Reference Centre for Staphylococci and Enterococci	50
Targeting multidrug resistance-associated protein 1 (MRP1)-expressing cancers: Beyond pharmacological inhibition	50
The key roles of the lysine acetyltransferases KAT6A and KAT6B in physiology and pathology	49
Regulation of cisplatin resistance in bladder cancer by epigenetic mechanisms	48
N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells	48
Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer	46
COVID-19 update: The race to therapeutic development	45
Cross-resistance and drug sequence in prostate cancer	44
Exosomal LOC85009 inhibits docetaxel resistance in lung adenocarcinoma through regulating ATG5-induced autophagy	43
Metallothionein isoforms as double agents – Their roles in carcinogenesis, cancer progression and chemoresistance	43
Selenium and tellurium in the development of novel small molecules and nanoparticles as cancer multidrug resistance reversal agents	41
Targeting metabolism to overcome cancer drug resistance: A promising therapeutic strategy for diffuse large B cell lymphoma	38
Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance	37
Emerging role of autophagy in anti-tumor immunity: Implications for the modulation of immunotherapy resistance	37
Resistance-proof antimicrobial drug discovery to combat global antimicrobial resistance threat	36
The Omicron variant of concern: Diversification and convergent evolution in spike protein, and escape from anti-Spike monoclonal antibodies	35
The role of extracellular vesicles in the transfer of drug resistance competences to cancer cells	35
KIAA1429 promotes tumorigenesis and gefitinib resistance in lung adenocarcinoma by activating the JNK/ MAPK pathway in an m6A-dependent manner	35
Molecular Modeling Strategies of Cancer Multidrug Resistance	35
In vitro biomimetic models for glioblastoma-a promising tool for drug response studies	34
Paclitaxel resistance related to nuclear envelope structural sturdiness	32
Nanotechnology-based approaches overcome lung cancer drug resistance through diagnosis and treatment	32
The strategic roles of four enzymes in the interconnection between metabolism and oncogene activation in non-small cell lung cancer: Therapeutic implications	32
Long non-coding RNAs (lncRNAs) signaling in cancer chemoresistance: From prediction to druggability	31
Rewiring chaperone-mediated autophagy in cancer by a prion-like chemical inducer of proximity to counteract adaptive immune resistance	29
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer	28
Revolutionizing non-conventional wound healing using honey by simultaneously targeting multiple molecular mechanisms	28
Why may citrate sodium significantly increase the effectiveness of transarterial chemoembolization in hepatocellular carcinoma?	28
Precision medicine: Ray of hope in overcoming cancer multidrug resistance	28