Drug Resistance Updates

Papers
(The median citation count of Drug Resistance Updates is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Editorial Board330
Modulating undruggable targets to overcome cancer therapy resistance247
Editorial Board212
N6-methyladenosine modification of 3'tRF-AlaAGC impairs PD-1 blockade efficacy by promoting lactic acid accumulation in the tumor microenvironment of gastric carcinoma159
Molecular subtype changes after acquiring resistance to tarlatamab in small cell lung cancer155
Plasmid-borne tigecycline resistance gene tet(X4) in Salmonella enterica and Escherichia coli isolates from a pediatric patient with diarrhea133
PARP inhibition elicits NK cell-associated immune evasion via potentiating HLA-G expression in tumor132
Overexpression of ABCC1 and ABCG2 confers resistance to talazoparib, a poly (ADP-Ribose) polymerase inhibitor128
Novel nanomedicines to overcome cancer multidrug resistance119
Sciatic nerve stimulation enhances NK cell cytotoxicity through dopamine signaling and synergizes immunotherapy in triple-negative breast cancer95
Unraveling the secrets: Evolution of resistance mediated by membrane proteins95
Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance93
Unveiling the resistance to therapies in pancreatic ductal adenocarcinoma93
New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects93
Evolution of RND efflux pumps in the development of a successful pathogen92
Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges92
Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant Klebsiella pneumoniae90
Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance87
Point mutation P174L of the penA gene endowing ceftazidime resistance to Burkholderia pseudomallei in China86
Editorial Board86
Tyrosine phosphorylation-mediated YAP1-TFAP2A interactions coordinate transcription and trastuzumab resistance in HER2+ breast cancer82
Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine81
Network biology and artificial intelligence drive the understanding of the multidrug resistance phenotype in cancer75
The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond73
Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma71
Treatment strategies and drug resistance mechanisms in adenocarcinoma of different organs69
Drug resistance mechanisms in dopamine agonist-resistant prolactin pituitary neuroendocrine tumors and exploration for new drugs69
Enzymatic bionanocatalysts for combating peri-implant biofilm infections by specific heat-amplified chemodynamic therapy and innate immunomodulation69
Targeting anoikis resistance as a strategy for cancer therapy65
TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770–5p axis in PDAC59
Editorial Board57
Novel mobile colistin resistance gene mcr-4.9 in Vibrio cholerae from migratory birds56
Research progress on gene mutations and drug resistance in leukemia53
Clinical implications of germline variations for treatment outcome and drug resistance for small molecule kinase inhibitors in patients with non-small cell lung cancer52
Heterogeneity of SOS response expression in clinical isolates of Escherichia coli influences adaptation to antimicrobial stress52
Global population structure and genomic surveillance framework of carbapenem-resistant Salmonella enterica51
Current therapy and drug resistance in metastatic castration-resistant prostate cancer50
Framework nucleic acid-based nanoparticles enhance temozolomide sensitivity in glioblastoma50
Emergence of silent NDM-1 carbapenemase gene in carbapenem-susceptible Klebsiella pneumoniae: Clinical implications and epidemiological insights48
Inhibition of NF-κB signaling unveils novel strategies to overcome drug resistance in cancers48
Overcoming cancer chemotherapy resistance by the induction of ferroptosis46
PDPN positive CAFs contribute to HER2 positive breast cancer resistance to trastuzumab by inhibiting antibody-dependent NK cell-mediated cytotoxicity45
Organoid models of drug resistant gastric adenosquamous carcinoma: Recapitulating tumor features and refining precision treatment44
Editorial Board43
Editorial Board43
Emergence of novel Klebsiella pneumoniae ST types with multidrug resistance in clinic42
Radioiodine-refractory differentiated thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance40
Mechanisms of sensitivity and resistance to CDK4/CDK6 inhibitors in hormone receptor-positive breast cancer treatment40
ABCB1-dependent collateral sensitivity of multidrug-resistant colorectal cancer cells to the survivin inhibitor MX106-4C39
Exosomal LOC85009 inhibits docetaxel resistance in lung adenocarcinoma through regulating ATG5-induced autophagy39
Research progress of therapeutic effects and drug resistance of immunotherapy based on PD-1/PD-L1 blockade39
Autophagy in cancer development, immune evasion, and drug resistance38
Global distribution and genomic characteristics of carbapenemase-producing Escherichia coli among humans, 2005–202336
LncRNA DYNLRB2-AS1 promotes gemcitabine resistance of nasopharyngeal carcinoma by inhibiting the ubiquitination degradation of DHX9 protein36
Dual specific phosphatase 4 suppresses ferroptosis and enhances sorafenib resistance in hepatocellular carcinoma35
Combinatorial approaches of nanotherapeutics for inflammatory pathway targeted therapy of prostate cancer35
Hypoxia as a driver of resistance to immunotherapy34
CRISPR-Cas system as a promising player against bacterial infection and antibiotic resistance34
CEA-induced PI3K/AKT pathway activation through the binding of CEA to KRT1 contributes to oxaliplatin resistance in gastric cancer34
Harnessing mitochondrial metabolism and drug resistance in non-small cell lung cancer and beyond by blocking heat-shock proteins34
GSK3β as a novel promising target to overcome chemoresistance in pancreatic cancer33
Un-methylation of NUDT21 represses docosahexaenoic acid biosynthesis contributing to enzalutamide resistance in prostate cancer32
Cellular and molecular mechanisms of gastrointestinal cancer liver metastases and drug resistance32
Characterization difference of typical KL1, KL2 and ST11-KL64 hypervirulent and carbapenem-resistant Klebsiella pneumoniae32
Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance31
Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation30
Solving the antibacterial resistance in Europe: The multipronged approach of the COST Action CA21145 EURESTOP30
Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer30
Characterization of NMCR-3, NMCR-4 and NMCR-5, three novel non-mobile colistin resistance determinants: Implications for MCR-3, MCR-7, and MCR-5 progenitors, respectively29
Monitoring tumour resistance to the BRAF inhibitor combination regimen in colorectal cancer patients via circulating tumour DNA29
NDRG1 overcomes resistance to immunotherapy of pancreatic ductal adenocarcinoma through inhibiting ATG9A-dependent degradation of MHC-128
Folylpolyglutamate synthetase inactivation in relapsed ALL induces a druggable folate metabolic vulnerability27
Breaking the barrier: Epigenetic strategies to combat platinum resistance in colorectal cancer27
Single-cell transcriptional profiling uncovers the association between EOMES+CD8+ T cells and acquired EGFR-TKI resistance25
Editorial Board25
Editorial Board24
Wip1 phosphatase activator QGC-8–52 specifically sensitizes p53-negative cancer cells to chemotherapy while protecting normal cells24
Circumventing drug resistance in gastric cancer: A spatial multi-omics exploration of chemo and immuno-therapeutic response dynamics24
The role of histone H1.2 in pancreatic cancer metastasis and chemoresistance24
Radioiodine therapy in advanced differentiated thyroid cancer: Resistance and overcoming strategy23
Concurrent inhibition of ALK and SRC kinases disrupts the ALK lung tumor cell proteome23
The definition and global epidemiology of nonmobile colistin resistance (NMCR-3) determinants in Aeromonas from 1968 to 202223
Ultrastructural, metabolic and genetic characteristics of determinants facilitating the acquisition of macrolide resistance by Streptococcus pneumoniae22
Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis22
Revolutionising infection control: building the next generation of phage banks22
Different mechanisms of drug resistance to hypomethylating agents in the treatment of myelodysplastic syndromes and acute myeloid leukemia21
O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictates sensitivity to sunitinib in renal cell carcinoma21
An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment20
CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis20
Impact of cancer metabolism on therapy resistance – Clinical implications20
Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae19
Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs19
Editorial Board18
Deciphering the genetic basis of resistome and virulome diversity among multidrug-resistant Mycoplasma hominis18
N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells18
An increased prevalence of carbapenem-resistant hypervirulent Klebsiella pneumoniae associated with the COVID-19 pandemic18
Thiol oxidative stress-dependent degradation of transglutaminase2 via protein S-glutathionylation sensitizes 5-fluorouracil therapy in 5-fluorouracil-resistant colorectal cancer cells17
Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangemen17
The strategic roles of four enzymes in the interconnection between metabolism and oncogene activation in non-small cell lung cancer: Therapeutic implications17
Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: An epidemiological, spatial, genomic analysis17
A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis16
The c-MYC-WDR43 signalling axis promotes chemoresistance and tumour growth in colorectal cancer by inhibiting p53 activity16
Surface chemistry engineered selenium nanoparticles as bactericidal and immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus Infection16
Molecular Modeling Strategies of Cancer Multidrug Resistance16
Association of idealized amphiphiles and protease inhibitors: Conferring antimicrobial peptides with stable antibacterial activity under physiological conditions to combat multidrug-resistant bacteria16
Intersecting pathways: The role of hybrid E/M cells and circulating tumor cells in cancer metastasis and drug resistance16
Targeting undruggable phosphatase overcomes trastuzumab resistance by inhibiting multi-oncogenic kinases16
Anticancer drug resistance: An update and perspective15
Dynamic evolution of KPC-230-mediated resistance to ceftazidime-avibactam during the treatment of carbapenem-resistant Klebsiella pnenmoniae15
New emerging SARS-CoV-2 variants and antiviral agents15
Editorial Board15
BCL7A inhibits the progression and drug-resistance in acute myeloid leukemia14
TRAIL-driven targeting and reversing cervical cancer radioresistance by seleno-nanotherapeutics through regulating cell metabolism14
Vaccine effects on COVID-19 infection with bivalent boosting by age group14
Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?14
Identification of TMexCD-TOprJ-producing carbapenem-resistant Gram-negative bacteria from hospital sewage14
Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency14
Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG214
The important role of lactylation in regulating DNA damage repair and tumor chemotherapy resistance13
Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers13
Editorial Board13
Tumor-acquired somatic mutation affects conformation to abolish ABCG2-mediated drug resistance13
Long non-coding RNAs (lncRNAs) signaling in cancer chemoresistance: From prediction to druggability13
Pdr5: A master of asymmetry12
Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer12
Precision medicine: Ray of hope in overcoming cancer multidrug resistance12
Targeting NQO1 induces ferroptosis and triggers anti-tumor immunity in immunotherapy-resistant KEAP1-deficient cancers12
Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin resistance of esophageal squamous cell carcinoma (ESCC) cells via regulating the activity of diacylglycerol kinase α (DGKα)/NOX4 axis12
Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer12
TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL412
CBX4 counteracts cellular senescence to desensitize gastric cancer cells to chemotherapy by inducing YAP1 SUMOylation11
Fighting drug-resistant lung cancer by induction of NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated ferroptosis11
Carbapenemase-loaded outer membrane vesicles protect Pseudomonas aeruginosa by degrading imipenem and promoting mutation of antimicrobial resistance gene11
Editorial Board11
Selenium and tellurium in the development of novel small molecules and nanoparticles as cancer multidrug resistance reversal agents11
Emerging role of autophagy in anti-tumor immunity: Implications for the modulation of immunotherapy resistance10
Phage-mediated colistin resistance in Acinetobacter baumannii10
Purinergic signalling in cancer therapeutic resistance: From mechanisms to targeting strategies10
Zebrafish patient-derived xenograft system for predicting carboplatin resistance and metastasis of ovarian cancer10
CYP1B1 promotes PARPi-resistance via histone H1.4 interaction and increased chromatin accessibility in ovarian cancer10
Circulating tumor cells with increasing aneuploidy predict inferior prognosis and therapeutic resistance in small cell lung cancer9
Combating bacterial infections with host defense peptides: Shifting focus from bacteria to host immunity9
Sanfetrinem, an oral β-lactam antibiotic repurposed for the treatment of tuberculosis9
RGS5+ lymphatic endothelial cells facilitate metastasis and acquired drug resistance of breast cancer through oxidative stress-sensing mechanism9
Editorial Board9
Silent circulation of plasmid-borne tet(X6) and blaOXA-58 genes in a community-acquired Acinetobacter baumannii strain9
Structure, function, and inhibition of catalytically asymmetric ABC transporters: Lessons from the PDR subfamily9
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