Drug Resistance Updates

Article	Citations
Editorial Board	635
Editorial Board	322
Plasmid-borne tigecycline resistance gene tet(X4) in Salmonella enterica and Escherichia coli isolates from a pediatric patient with diarrhea	277
PARP inhibition elicits NK cell-associated immune evasion via potentiating HLA-G expression in tumor	261
Overexpression of ABCC1 and ABCG2 confers resistance to talazoparib, a poly (ADP-Ribose) polymerase inhibitor	245
Molecular subtype changes after acquiring resistance to tarlatamab in small cell lung cancer	240
N6-methyladenosine modification of 3'tRF-AlaAGC impairs PD-1 blockade efficacy by promoting lactic acid accumulation in the tumor microenvironment of gastric carcinoma	233
Erratum to “A highly potent small-molecule antagonist of exportin-1 selectively eliminates CD44+ CD24- enriched breast cancer stem-like cells” [Drug Resist. Updates 66 (2023) 100903]	222
Unraveling the secrets: Evolution of resistance mediated by membrane proteins	192
Oridonin derivative DLC13 targeting proliferating cell nuclear antigen to overcome oxaliplatin resistance in colorectal cancer	177
New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects	157
Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance	154
Sciatic nerve stimulation enhances NK cell cytotoxicity through dopamine signaling and synergizes immunotherapy in triple-negative breast cancer	154
Unveiling the resistance to therapies in pancreatic ductal adenocarcinoma	150
Profiling the landscape of carbapenem resistance and hypervirulence in Klebsiella pneumoniae: A global epidemiological analysis of the plasmidome	147
Novel insights into taxane pharmacology: An update on drug resistance mechanisms, immunomodulation and drug delivery strategies	140
Meropenem-driven amplification of blaAFM-1 leads to high-level cefiderocol resistance in difficult-to-treat Pseudomonas aeruginosa	139
Editorial Board	132
Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance	122
Point mutation P174L of the penA gene endowing ceftazidime resistance to Burkholderia pseudomallei in China	120
A novel frameshift mutation in a case of therapy-resistant metastatic pheochromocytoma	117
Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant Klebsiella pneumoniae	109
Tyrosine phosphorylation-mediated YAP1-TFAP2A interactions coordinate transcription and trastuzumab resistance in HER2+ breast cancer	106
A novel platinum(IV) prodrug, gramine-Pt(IV) enhances chemoimmunotherapy by activating cGAS-STING and modulating TGF-β-MHC-I axis	97
Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges	95

Evolution of RND efflux pumps in the development of a successful pathogen	95
Targeting DNA damage response pathways in tumor drug resistance: Mechanisms, clinical implications, and future directions	87
Peptide nanonet trapping suppresses bacterial motility and delays antibiotic resistance emergence	82
MZF1-mediated GAPDH overexpression drives glycolytic reprogramming and neuroendocrine progression in advanced prostate cancer	82
IFNα2b modulates anti-tumor immune responses involving STAT3-associated dendritic cell dysfunction in JAK2v617f-positive myeloproliferative neoplasms	81
The novel strategy to overcome the drug-resistant lung cancer: Dual targeting delivery of PROTAC to inhibit cancer-associated fibroblasts and lung cancer cells	79
TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770–5p axis in PDAC	78
Treatment strategies and drug resistance mechanisms in adenocarcinoma of different organs	77
Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma	73
Drug resistance mechanisms in dopamine agonist-resistant prolactin pituitary neuroendocrine tumors and exploration for new drugs	72
Enzymatic bionanocatalysts for combating peri-implant biofilm infections by specific heat-amplified chemodynamic therapy and innate immunomodulation	71
The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond	70
Research progress on gene mutations and drug resistance in leukemia	68
Editorial Board	68
Targeting anoikis resistance as a strategy for cancer therapy	68
Novel mobile colistin resistance gene mcr-4.9 in Vibrio cholerae from migratory birds	67
Molecular profiling of chemotherapy-resistant breast cancer reveals DNA methylation remodeling associated with the acquisition of paclitaxel resistance	64
Heterogeneity of SOS response expression in clinical isolates of Escherichia coli influences adaptation to antimicrobial stress	64
Emergence of silent NDM-1 carbapenemase gene in carbapenem-susceptible Klebsiella pneumoniae: Clinical implications and epidemiological insights	64
Global population structure and genomic surveillance framework of carbapenem-resistant Salmonella enterica	62
PDPN positive CAFs contribute to HER2 positive breast cancer resistance to trastuzumab by inhibiting antibody-dependent NK cell-mediated cytotoxicity	62
Inhibition of NF-κB signaling unveils novel strategies to overcome drug resistance in cancers	61
The role of tumor microenvironment and signaling pathways in regulating breast cancer stem cells: Implications for therapy resistance and tumor recurrence	61
Myeloid immune checkpoint blockade overcomes antibiotic resistance in bone infection by enhancing efferocytosis and suppressing MSC PANoptosis	58
Single-cell transcriptome analysis of patient-derived organoids captures inter- and intratumor heterogeneity and uncovers targetable pathways in high grade serous ovarian cancer	57
Framework nucleic acid-based nanoparticles enhance temozolomide sensitivity in glioblastoma	57
Current therapy and drug resistance in metastatic castration-resistant prostate cancer	56
Overcoming cancer chemotherapy resistance by the induction of ferroptosis	56
Emergence of novel Klebsiella pneumoniae ST types with multidrug resistance in clinic	55
Editorial Board	52
Editorial Board	52
Endothelial SMAD1-MCAM axis facilitates sunitinib resistance and progression of clear cell renal cell carcinoma via LAMB1-ITGB1 signaling	52
Organoid models of drug resistant gastric adenosquamous carcinoma: Recapitulating tumor features and refining precision treatment	51
The role of synthetic lethality in overcoming cancer therapy resistance: Emerging paradigm and recent advances	51
Exosomal LOC85009 inhibits docetaxel resistance in lung adenocarcinoma through regulating ATG5-induced autophagy	51
Global, regional, and national disease burden of multidrug-resistant tuberculosis without extensive drug resistance, 1990–2021: Findings from the Global Burden of Disease Study 2021	50
Radioiodine-refractory differentiated thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance	50
Mechanisms of therapy resistance in the tumor microenvironment: Insights from antibody array–based cytokine profiling	49
Global distribution and genomic characteristics of carbapenemase-producing Escherichia coli among humans, 2005–2023	48
Mechanisms of sensitivity and resistance to CDK4/CDK6 inhibitors in hormone receptor-positive breast cancer treatment	48
EMT and cancer stem cells: Drivers of therapy resistance and promising therapeutic targets	48
Autophagy in cancer development, immune evasion, and drug resistance	47
ABCB1-dependent collateral sensitivity of multidrug-resistant colorectal cancer cells to the survivin inhibitor MX106-4C	47
Research progress of therapeutic effects and drug resistance of immunotherapy based on PD-1/PD-L1 blockade	46
Ferroptosis and the cGAS–STING pathway into precision nano-immuno-theranostics: A mechanistic paradigm for reversing drug resistance in hepatocellular carcinoma	45
Combinatorial approaches of nanotherapeutics for inflammatory pathway targeted therapy of prostate cancer	45
RCN2 facilitates esophageal squamous cellular carcinoma metastasis and cisplatin resistance through UBR5-mediated PPP2CA ubiquitination and degradation	44
Mechanisms and determinants of bacterial susceptibility to antimicrobial Blue Light: From chromophores to transcriptomes	43
Combination of PD-1 blockade and neoadjuvant chemoradiotherapy benefits pMMR/MSS patients with locally advance rectal cancer: A phase 2 clinical trial	43
CEA-induced PI3K/AKT pathway activation through the binding of CEA to KRT1 contributes to oxaliplatin resistance in gastric cancer	42

CRISPR-Cas system as a promising player against bacterial infection and antibiotic resistance	42
Activating ZBP1-centered PANoptosis and a collaborative innate-adaptive immune response sensitizes glioblastoma to PD-1 blockade	42
Dual specific phosphatase 4 suppresses ferroptosis and enhances sorafenib resistance in hepatocellular carcinoma	42
Harnessing mitochondrial metabolism and drug resistance in non-small cell lung cancer and beyond by blocking heat-shock proteins	40
Targeting SLC7A11 with sorafenib sensitizes stereotactic body radiotherapy in colorectal cancer liver metastasis	40
Cellular and molecular mechanisms of gastrointestinal cancer liver metastases and drug resistance	38
MicroRNA-mediated PTEN downregulation as a novel non-genetic mechanism of acquired resistance to PI3Kα inhibitors of head & neck squamous cell carcinoma	38
Un-methylation of NUDT21 represses docosahexaenoic acid biosynthesis contributing to enzalutamide resistance in prostate cancer	38
LncRNA DYNLRB2-AS1 promotes gemcitabine resistance of nasopharyngeal carcinoma by inhibiting the ubiquitination degradation of DHX9 protein	38
Metabolic basis of fatty acid oxidation and immunotherapy resistance with clinical perspectives	38
Characterization difference of typical KL1, KL2 and ST11-KL64 hypervirulent and carbapenem-resistant Klebsiella pneumoniae	37
Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance	37
Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer	37
Breaking the barrier: Epigenetic strategies to combat platinum resistance in colorectal cancer	37
Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation	37
Advances and resistance adaptation in BTK-targeted therapy for B-cell malignancies	37
Monitoring tumour resistance to the BRAF inhibitor combination regimen in colorectal cancer patients via circulating tumour DNA	36
Characterization of NMCR-3, NMCR-4 and NMCR-5, three novel non-mobile colistin resistance determinants: Implications for MCR-3, MCR-7, and MCR-5 progenitors, respectively	35
NDRG1 overcomes resistance to immunotherapy of pancreatic ductal adenocarcinoma through inhibiting ATG9A-dependent degradation of MHC-1	35
Solving the antibacterial resistance in Europe: The multipronged approach of the COST Action CA21145 EURESTOP	34
Emerging role of sialylation in cancer therapy resistance: Mechanisms and therapeutic implications	34
Folylpolyglutamate synthetase inactivation in relapsed ALL induces a druggable folate metabolic vulnerability	34
Endothelial cells sense temozolomide resistance to facilitate monocyte-derived macrophage infiltration in glioblastoma	34
Nanoparticles-mediated mitochondrial relocation of lipid-lowering drugs shape energy metabolism to conquer acquired immune resistance	34
Targeting CLK1/SRSF7 axis-dependent alternative splicing sensitizes pancreatic ductal adenocarcinoma to chemotherapy and immunotherapy	34
Editorial Board	33
Radioiodine therapy in advanced differentiated thyroid cancer: Resistance and overcoming strategy	32
Wip1 phosphatase activator QGC-8–52 specifically sensitizes p53-negative cancer cells to chemotherapy while protecting normal cells	32
Concurrent inhibition of ALK and SRC kinases disrupts the ALK lung tumor cell proteome	32
Single-cell transcriptional profiling uncovers the association between EOMES+CD8+ T cells and acquired EGFR-TKI resistance	32
The emerging role of AXL in pancreatic cancer: Biomarker potential and therapeutic targeting to counteract drug resistance	32
The role of histone H1.2 in pancreatic cancer metastasis and chemoresistance	32
Widespread antibiotic heterotolerance in bacteria remains undetected by resistance assays	31
Circumventing drug resistance in gastric cancer: A spatial multi-omics exploration of chemo and immuno-therapeutic response dynamics	31
CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis	31
Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis	30
AMPKα2 attenuates doxorubicin induced ferroptosis by promoting NCOA4 degradation in triple negative breast cancer	30
The definition and global epidemiology of nonmobile colistin resistance (NMCR-3) determinants in Aeromonas from 1968 to 2022	30
Ultrastructural, metabolic and genetic characteristics of determinants facilitating the acquisition of macrolide resistance by Streptococcus pneumoniae	30
The multifaceted contributions of cancer-associated fibroblasts to drug resistance in primary and metastatic tumors	29
DEAF1 confers resistance to adriamycin-induced apoptosis and pyroptosis in multiple myeloma	29
Glucocorticoid receptor activated by dexamethasone promotes the chemoresistance and stemness of lung cancer	29
Revolutionising infection control: building the next generation of phage banks	29
Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs	28
Deciphering the genetic basis of resistome and virulome diversity among multidrug-resistant Mycoplasma hominis	28
O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictates sensitivity to sunitinib in renal cell carcinoma	28
Editorial Board	28
Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae	28
HSA-templated synergistic platform boosts radiotherapy via enhanced radiosensitization and ferroptosis induction	27
Thiol oxidative stress-dependent degradation of transglutaminase2 via protein S-glutathionylation sensitizes 5-fluorouracil therapy in 5-fluorouracil-resistant colorectal cancer cells	27
Exosome-derived lnc-FAM72D-3 promotes lenvatinib resistance by remodeling hepatocellular carcinoma cytoskeleton via MBNL1/FAK axis	26
N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells	26
Gamma-synuclein drives bevacizumab resistance in colorectal cancer via VEGFR2 activation and angiogenesis	26
Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: An epidemiological, spatial, genomic analysis	25
ENO1 lactylation drives bevacizumab resistance through metabolic reprogramming and angiogenesis in ovarian cancer	25
An increased prevalence of carbapenem-resistant hypervirulent Klebsiella pneumoniae associated with the COVID-19 pandemic	25
A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis	24
Entinostat overcomes cisplatin resistance in bladder cancer by promoting H3K18la-mediated DHRS2 expression and nuclear translocation to suppress the AKR1C3-androgen axis	24
Association of idealized amphiphiles and protease inhibitors: Conferring antimicrobial peptides with stable antibacterial activity under physiological conditions to combat multidrug-resistant bacteria	24
Defining homologous recombination deficiency status in pancreatic ductal adenocarcinoma: Clinical implications for evaluating response to platinum chemotherapy	24
Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangemen	24
The c-MYC-WDR43 signalling axis promotes chemoresistance and tumour growth in colorectal cancer by inhibiting p53 activity	24
Surface chemistry engineered selenium nanoparticles as bactericidal and immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus Infection	23
Intersecting pathways: The role of hybrid E/M cells and circulating tumor cells in cancer metastasis and drug resistance	23
New emerging SARS-CoV-2 variants and antiviral agents	23
Targeting undruggable phosphatase overcomes trastuzumab resistance by inhibiting multi-oncogenic kinases	23
RNA-binding motif protein 15 promotes gastric cancer growth and drug resistance via USP10-mediated deubiquitination and stabilization of nuclear NRF2	23
Beyond the boundary: The emerging roles of ATP-binding cassette transporters in multidrug resistance (MDR) and therapeutic targeting in cancer	23
Editorial Board	23
Overcoming resistance in oncolytic virotherapy: Nano-engineered solutions for systemic delivery and efficacy boost	23
Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2	22
ZBED6-Driven Nucleotide Metabolic Reprogramming Improves Sensitivity to anti-PD1 Therapy in NK/T Cell Lymphoma	22
BCL7A inhibits the progression and drug-resistance in acute myeloid leukemia	22
DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma	22
Vaccine effects on COVID-19 infection with bivalent boosting by age group	22
Editorial Board	22
Targeting the USP5–HSPB1 axis overcomes ferroptosis resistance in intrahepatic cholangiocarcinoma	21
Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?	21
TRAIL-driven targeting and reversing cervical cancer radioresistance by seleno-nanotherapeutics through regulating cell metabolism	21
Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency	21

Dynamic evolution of KPC-230-mediated resistance to ceftazidime-avibactam during the treatment of carbapenem-resistant Klebsiella pnenmoniae	21
Long non-coding RNAs (lncRNAs) signaling in cancer chemoresistance: From prediction to druggability	20
CD105 blockade restores osimertinib sensitivity in drug-resistant EGFR-mutant non-small cell lung cancer	20
Identification of TMexCD-TOprJ-producing carbapenem-resistant Gram-negative bacteria from hospital sewage	20
Engineering nanoplatforms of bacterial outer membrane vesicles to overcome cancer therapy resistance	20
Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers	20
The important role of lactylation in regulating DNA damage repair and tumor chemotherapy resistance	20
Editorial Board	19
Precision medicine: Ray of hope in overcoming cancer multidrug resistance	18
Targeting TRAP1-dependent metabolic reprogramming to overcome doxorubicin resistance in quiescent breast cancer	18
Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer	18
Difluoroboron curcumin/glycyrrhizic acid liposome-incorporated Mg²⁺-chelated microgel for MRSA-infected wound photothermal therapy	18
Deciphering the roles of AcrAB-TolC efflux pump in promoting the transmission of antibiotic resistance	18
Tumor-acquired somatic mutation affects conformation to abolish ABCG2-mediated drug resistance	18
Pdr5: A master of asymmetry	18
Acetylation-mediated fluconazole inactivation: A novel antifungal resistance mechanism	18
Disruption of NANOG-driven epithelial-mesenchymal transition (EMT) and self-renewal restores drug sensitivity in colorectal cancer	18
UBL3 governs VEGFR inhibitor resistance by activating NOTCH signaling in renal cell carcinoma	18
The c-Myc-USP14-PFKP axis sustains chemoresistance in pancreatic ductal adenocarcinoma	17
Fighting drug-resistant lung cancer by induction of NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated ferroptosis	17
Editorial Board	17
CBX4 counteracts cellular senescence to desensitize gastric cancer cells to chemotherapy by inducing YAP1 SUMOylation	17
Perineural invasion in head and neck squamous cell carcinoma: Neuro-immune mechanisms driving immunotherapy resistance and emerging therapeutic strategies	17
Carbapenemase-loaded outer membrane vesicles protect Pseudomonas aeruginosa by degrading imipenem and promoting mutation of antimicrobial resistance gene	17
Targeting NQO1 induces ferroptosis and triggers anti-tumor immunity in immunotherapy-resistant KEAP1-deficient cancers	17
Purinergic signalling in cancer therapeutic resistance: From mechanisms to targeting strategies	16
Mechanisms of resistance to antibody-drug conjugates in breast cancer	16
The sRNA-encoded peptide TimP rewires the Escherichia coli envelope via LamB to sensitize bacteria to polymyxins	16
Editorial Board	16
Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer	16
Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin resistance of esophageal squamous cell carcinoma (ESCC) cells via regulating the activity of diacylglycerol kinase α (DGKα)/NOX4 axis	16
TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL4	16
Interferon regulatory factor 5 associated neutrophil reprogramming by trained immunity protects against lethal-dose bacterial sepsis	15
Structure, function, and inhibition of catalytically asymmetric ABC transporters: Lessons from the PDR subfamily	15
CYP1B1 promotes PARPi-resistance via histone H1.4 interaction and increased chromatin accessibility in ovarian cancer	15
Combating bacterial infections with host defense peptides: Shifting focus from bacteria to host immunity	15
Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial	15
RGS5+ lymphatic endothelial cells facilitate metastasis and acquired drug resistance of breast cancer through oxidative stress-sensing mechanism	15
Exosomal CircGANAB promotes cancer progression and immunotherapy resistance by degrading interacting RNAs and limiting T cell infiltration in pancreatic ductal adenocarcinoma	15
Zebrafish patient-derived xenograft system for predicting carboplatin resistance and metastasis of ovarian cancer	15
Phage-mediated colistin resistance in Acinetobacter baumannii	15
Low dose radiation induces new protein synthesis that promotes cancer radiotherapy resistance	14
Novel quinoxaline-based survivin degraders overcome docetaxel-resistance in castration-resistant prostate cancer	14
Silent circulation of plasmid-borne tet(X6) and blaOXA-58 genes in a community-acquired Acinetobacter baumannii strain	14
Corrigendum to “Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae” [Drug Resist. Updat. 66 (2023) 100891]	13
Circulating tumor cells with increasing aneuploidy predict inferior prognosis and therapeutic resistance in small cell lung cancer	13
Paclitaxel resistance related to nuclear envelope structural sturdiness	13
Acquired non-thermal plasma resistance mediates a shift towards aerobic glycolysis and ferroptotic cell death in melanoma	13
Local structural constraints and charge distribution in the protegrin-1 arginine loop govern activity against colistin-resistant Klebsiella pneumoniae.	13