OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Chemical Biology is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Fluorogenic polymethine dyes by intramolecular cyclization	203
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes	132
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	130
Glycoengineering in antigen-specific immunotherapies	91
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	87
Imaging of proteases using activity-based probes	71
Small-molecule modulators of protein–RNA interactions	70
Engineered metallobiocatalysts for energy–relevant reactions	67
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	62
Synthetic transporters for oxoanions	58
Extendable and explainable deep learning for pan-cancer radiogenomics research	57
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications	56
Recent advances in methods for quantifying the cell penetration of macromolecules	52
Caged lipid probes for controlling lipid levels on subcellular scales	52
The Ramifications of synthetic biology	51
Characteristics of genetic tags for correlative light and electron microscopy	50
Activity-based protein profiling in microbes and the gut microbiome	49
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	47
Site-specific bioconjugation and nuclear imaging	46
New strategies for fluorescently labeling proteins in the study of amyloids	45
Chemical inhibitors of transcription-associated kinases	44
Chemical engineering of bacterial effectors for regulating cell signaling and responses	43
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	43
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	41
Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	41

Genetically encoded fluorescent sensors for metals in biology	40
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	40
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	39
Chemical probes for tagging mycobacterial lipids	39
Advances in the understanding and exploitation of carbohydrate-active enzymes	38
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	37
Critical considerations in N-glycoproteomics	37
Highlighting the roles of transition metals and speciation in chemical biology	37
Editorial Board	36
Chemistry and biology of enzymes in protein glutathionylation	36
Editorial Board	36
Chemical approaches for investigating site-specific protein S-fatty acylation	34
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	34
Natural and engineered precision antibiotics in the context of resistance	33
Understanding and controlling amyloid aggregation with chirality	33
Super-multiplexed vibrational probes: Being colorful makes a difference	33
Mechanism and inhibition of BRAF kinase	33
How nature incorporates sulfur and selenium into bioactive natural products	32
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	32
Protein sequence design with deep generative models	32
Recent advances in computational algorithms and software for large-scale glycoproteomics	31
Virus-assisted directed evolution of biomolecules	31
Catalytic amyloids: Is misfolding folding?	31
Editorial: Unusual enzyme reactions in natural products biosynthesis	31
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	30
Sulfoxides in medicine	29
Recent progress of TP/NIR fluorescent probes for metal ions	29
Emerging mammalian gene switches for controlling implantable cell therapies	29
Induced proximity tools for precise manipulation of lipid signaling	29
Targeted protein degradation: Emerging concepts and protein state-specific targeting principles	29
Cysteine and methionine oxidation in thrombotic disorders	28
Recent advances in N- and C-terminus cysteine protein bioconjugation	28
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	28
Transferring enzyme features to molecular CO2 reduction catalysts	28
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	28
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	28
Exploring amyloid oligomers with peptide model systems	27
Bacterial peptidoglycan as a living polymer	27
SOD mimics: From the tool box of the chemists to cellular studies	26
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	26
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	26
Synthetic peptide scaffolds as ion channels and molecular carriers	26
Synthesis and application of bacterial exopolysaccharides	26
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	26
Peptides for disrupting and degrading amyloids	25
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	25
Promoting remyelination: A case study in regenerative medicine	25
Molecular glues to stabilise protein–protein interactions	25
New frontiers in sulfur and selenium chemical biology	25
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	25

Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	24
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	24
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	24
Editorial overview: Amyloid-inspired synthetic biomolecules	24
Fluorescent indicators for imaging membrane potential of organelles	24
Inhibitors of DHHC family proteins	24
Editorial Board	23
Editorial overview: Synthetic biomolecules for probing lipid membranes	23
Editorial Board	22
Editorial Board	22
Analytical techniques in chemical biology	22
Editorial overview: Glycobiology (2024)	21
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	21
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport	21
Editorial overview: Recent advances in metabolomics	21
Protein-based models offer mechanistic insight into complex nickel metalloenzymes	21
Engineering the bilayer: Emerging genetic tool kits for mechanistic lipid biology	20
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	20
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	20
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	20
Glutathione dynamics in subcellular compartments and implications for drug development	20
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	20
Image-based cell phenotyping with deep learning	20
Metalloprotein enabled redox signal transduction in microbes	20
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	20
Editorial: Mechanistic biology	19
Lipidomics analysis in drug discovery and development	19
Editorial Board	19
Catalyzing the future: recent advances in chemical synthesis using enzymes	19
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	19
Sensing and regulation of reactive sulfur species (RSS) in bacteria	19
Discovery and evolution of [4 + 2] cyclases	18
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems	18
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	18
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	18
Recent progress on small molecules targeting epigenetic complexes	18
Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141	18
The non-catalytic domains of O-GlcNAc cycling enzymes present new opportunities for function-specific control	18
Strategies in engineering sustainable biochemical synthesis through microbial systems	18