OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Chemical Biology is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-03-01 to 2025-03-01.)

Article	Citations
Natural and engineered transglycosylases: Green tools for the enzyme-based synthesis of glycoproducts	168
New analytical methods focusing on polar metabolite analysis in mass spectrometry and NMR-based metabolomics	114
Decoding the cellular effects of genetic variation through interaction proteomics	95
Direct visualization and profiling of protein misfolding and aggregation in live cells	91
New chemical processes to streamline carbohydrate synthesis	83
Editorial Board	80
Imaging of proteases using activity-based probes	80
Covalent labeling of immune cells	67
Editorial Board	67
Editorial overview: Imaging metal ions in biological systems	58
Synthesis and application of bacterial exopolysaccharides	57
Small molecule fluorescent probes for the study of protein phase separation	55
Editorial Board	54
How are hydrogen peroxide messages relayed to affect cell signalling?	51
Recent progresses in the cyclization and oxidation of polyketide biosynthesis	49
Recent advances in induced proximity modalities	48
MicroRNA:Siglec crosstalk in cancer progression	48
In silico, in vitro, and in vivo machine learning in synthetic biology and metabolic engineering	48
Recent advances in developing degraders & inhibitors of lysine methyltransferases	48
Advanced functional fluorescent probes for cell plasma membranes	47
Electrophilic metabolites targeting the KEAP1/NRF2 partnership	47
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	46
Sulfur-containing marine natural products as leads for drug discovery and development	45
Microbial metabolite-receptor interactions in the gut microbiome	44
Programmable tools for targeted analysis of epigenetic DNA modifications	43

Engineered metallobiocatalysts for energy–relevant reactions	43
NMR spectroscopy to study the fate of metallodrugs in cells	41
From structure to application: Progress and opportunities in peptide materials development	41
Exploring amyloid oligomers with peptide model systems	41
Recent advances in intravital microscopy for preclinical research	39
Supramolecular coordination complexes as diagnostic and therapeutic agents	38
Development of effective therapeutics for polysubstance use disorders	38
Corrigendum to “Shedding light on complexity of protein–protein interactions in cancer” [Curr Opin Chem Biol 53 (2019) 75-81]	37
Peptides for disrupting and degrading amyloids	36
Drugging the undruggable proteins in cancer: A systems biology approach	35
Recent advances in drug repurposing using machine learning	35
Toward synthetic life: Biomimetic synthetic cell communication	34
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	33
Chemical regulation of the cGAS-STING pathway	33
Imaging organelle membranes in live cells at the nanoscale with lipid-based fluorescent probes	33
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	33
Characterising biomolecular interactions and dynamics with mass photometry	33
Emerging frontiers in virtual drug discovery: From quantum mechanical methods to deep learning approaches	32
Chemical biology tools for imaging-based analysis of organelle membranes and lipids	31
Tuning specificity and topology of lectins through synthetic biology	30
Chemical tools targeting readers of lysine methylation	30
Recent advances in data- and knowledge-driven approaches to explore primary microbial metabolism	29
Small-angle X-ray scattering studies of enzymes	29
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics	28
Promising heterometallic compounds as anticancer agents: Recent studies in vivo	28
Small-molecule modulators of protein–RNA interactions	28
Towards sequence-based principles for protein phase separation predictions	28
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	27
Activity-based probes in pathogenic bacteria: Investigating drug targets and molecule specificity	27
Luminescent lanthanide probes for cations and anions: Promises, compromises, and caveats	27
Fluorogenic polymethine dyes by intramolecular cyclization	27
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	27
Role of conformational dynamics in pathogenic protein aggregation	27
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	26
Bacterial peptidoglycan as a living polymer	26
Recent advances in the design and optimization of artificial metalloenzymes	26
Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles	26
Probing immune infiltration dynamics in cancer by in vivo imaging	25
SOD mimics: From the tool box of the chemists to cellular studies	25
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	24
Enzymatic strategies for selenium incorporation into biological molecules	24
Strategies and mechanisms for endosomal escape of therapeutic nucleic acids	24
Glycoengineering in antigen-specific immunotherapies	24
An expanded molecular and systems toolbox for imaging, mapping, and controlling local translation	23
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	23
Biochemistry of the hypoxia-inducible factor hydroxylases	23
The chemical biology of NAD+ regulation in axon degeneration	22
Recent progress in metal-based molecular probes for optical bioimaging and biosensing	22
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	22
Molecular glues to stabilise protein–protein interactions	22

Mass spectrometry techniques for imaging and detection of metallodrugs	22
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	22
Endogenous electrophiles and peroxymonocarbonate can link tyrosine phosphorylation cascades with the cytosolic TXNRD1 selenoprotein and the KEAP1/NRF2 system	22
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region	21
Current mechanistic understanding of intermembrane lipid trafficking important for maintenance of bacterial outer membrane lipid asymmetry	21
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level	21
Fluorescent indicators for imaging membrane potential of organelles	21
Synthetic peptide scaffolds as ion channels and molecular carriers	21
Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging	20
Editorial overview: Glycobiology (2023)	20
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides	20
A new era of cysteine proteomics – Technological advances in thiol biology	20
New frontiers in sulfur and selenium chemical biology	20
The Ramifications of synthetic biology	19
Editorial Board	19
Activity-based protein profiling in microbes and the gut microbiome	19
Publisher’s Note	19
Shedding light on current trends in molecular optogenetics	19
Emerging fluorescence tools for the study of proteostasis in cells	19
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis	19
Deciphering combinatorial post-translational modifications by top-down mass spectrometry	19
Emerging roles of low-molecular-weight thiols at the host–microbe interface	19
Recent advances in photoaffinity labeling strategies to capture Glycan–Protein interactions	18
Recent research progress in glycosylphosphatidylinositol-anchored protein biosynthesis, chemical/chemoenzymatic synthesis, and interaction with the cell membrane	18
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	17
Cytokine engineering for targeted cancer immunotherapy	17
Recent progress in synthesis of carbohydrates with sugar nucleotide-dependent glycosyltransferases	17
Developing photoactivated artificial enzymes for sustainable fuel production	17
New strategies for fluorescently labeling proteins in the study of amyloids	17
Metal complexes as optical probes for DNA sensing and imaging	17
Advancements in boron difluoride formazanate dyes for biological imaging	17
Transition metal catalysts for the bioorthogonal synthesis of bioactive agents	17
Synthetic probes and chemical tools in sphingolipid research	17
Consequences of post-translational modifications on amyloid proteins as revealed by protein semisynthesis	16
Maximizing content across scales: Moving multimodal microscopy and mesoscopy toward molecular imaging	16
Improved methods for targeting epigenetic reader domains of acetylated and methylated lysine	16
Harnessing the power of directed evolution to improve genome editing systems	16
Inhibitors of DHHC family proteins	16
Extendable and explainable deep learning for pan-cancer radiogenomics research	16
Deuterium Raman imaging for lipid analysis	15
Compounds for selective translational inhibition	15
Characteristics of genetic tags for correlative light and electron microscopy	15
Caged lipid probes for controlling lipid levels on subcellular scales	15
Molecular simulations of complex carbohydrates and glycoconjugates	15
Engaging with benzoyllysine through a π-π-π mechanism	15
Recent advances in ratiometric fluorescence imaging of enzyme activity in vivo	15
Convergent and divergent biosynthetic strategies towards phosphonic acid natural products	15
Promoting remyelination: A case study in regenerative medicine	15
Recent progress in mass spectrometry for single-cell metabolomics	15
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	15