Current Opinion in Chemical Biology

Papers
(The TQCC of Current Opinion in Chemical Biology is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-03-01 to 2025-03-01.)
ArticleCitations
Natural and engineered transglycosylases: Green tools for the enzyme-based synthesis of glycoproducts168
New analytical methods focusing on polar metabolite analysis in mass spectrometry and NMR-based metabolomics114
Decoding the cellular effects of genetic variation through interaction proteomics95
Direct visualization and profiling of protein misfolding and aggregation in live cells91
New chemical processes to streamline carbohydrate synthesis83
Editorial Board80
Imaging of proteases using activity-based probes80
Covalent labeling of immune cells67
Editorial Board67
Editorial overview: Imaging metal ions in biological systems58
Synthesis and application of bacterial exopolysaccharides57
Small molecule fluorescent probes for the study of protein phase separation55
Editorial Board54
How are hydrogen peroxide messages relayed to affect cell signalling?51
Recent progresses in the cyclization and oxidation of polyketide biosynthesis49
Recent advances in induced proximity modalities48
MicroRNA:Siglec crosstalk in cancer progression48
In silico, in vitro, and in vivo machine learning in synthetic biology and metabolic engineering48
Recent advances in developing degraders & inhibitors of lysine methyltransferases48
Advanced functional fluorescent probes for cell plasma membranes47
Electrophilic metabolites targeting the KEAP1/NRF2 partnership47
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm46
Sulfur-containing marine natural products as leads for drug discovery and development45
Microbial metabolite-receptor interactions in the gut microbiome44
Programmable tools for targeted analysis of epigenetic DNA modifications43
Engineered metallobiocatalysts for energy–relevant reactions43
NMR spectroscopy to study the fate of metallodrugs in cells41
From structure to application: Progress and opportunities in peptide materials development41
Exploring amyloid oligomers with peptide model systems41
Recent advances in intravital microscopy for preclinical research39
Supramolecular coordination complexes as diagnostic and therapeutic agents38
Development of effective therapeutics for polysubstance use disorders38
Corrigendum to “Shedding light on complexity of protein–protein interactions in cancer” [Curr Opin Chem Biol 53 (2019) 75-81]37
Peptides for disrupting and degrading amyloids36
Drugging the undruggable proteins in cancer: A systems biology approach35
Recent advances in drug repurposing using machine learning35
Toward synthetic life: Biomimetic synthetic cell communication34
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes33
Chemical regulation of the cGAS-STING pathway33
Imaging organelle membranes in live cells at the nanoscale with lipid-based fluorescent probes33
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions33
Characterising biomolecular interactions and dynamics with mass photometry33
Emerging frontiers in virtual drug discovery: From quantum mechanical methods to deep learning approaches32
Chemical biology tools for imaging-based analysis of organelle membranes and lipids31
Tuning specificity and topology of lectins through synthetic biology30
Chemical tools targeting readers of lysine methylation30
Recent advances in data- and knowledge-driven approaches to explore primary microbial metabolism29
Small-angle X-ray scattering studies of enzymes29
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics28
Promising heterometallic compounds as anticancer agents: Recent studies in vivo28
Small-molecule modulators of protein–RNA interactions28
Towards sequence-based principles for protein phase separation predictions28
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis27
Activity-based probes in pathogenic bacteria: Investigating drug targets and molecule specificity27
Luminescent lanthanide probes for cations and anions: Promises, compromises, and caveats27
Fluorogenic polymethine dyes by intramolecular cyclization27
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging27
Role of conformational dynamics in pathogenic protein aggregation27
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops26
Bacterial peptidoglycan as a living polymer26
Recent advances in the design and optimization of artificial metalloenzymes26
Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles26
Probing immune infiltration dynamics in cancer by in vivo imaging25
SOD mimics: From the tool box of the chemists to cellular studies25
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities24
Enzymatic strategies for selenium incorporation into biological molecules24
Strategies and mechanisms for endosomal escape of therapeutic nucleic acids24
Glycoengineering in antigen-specific immunotherapies24
An expanded molecular and systems toolbox for imaging, mapping, and controlling local translation23
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones23
Biochemistry of the hypoxia-inducible factor hydroxylases23
The chemical biology of NAD+ regulation in axon degeneration22
Recent progress in metal-based molecular probes for optical bioimaging and biosensing22
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes22
Molecular glues to stabilise protein–protein interactions22
Mass spectrometry techniques for imaging and detection of metallodrugs22
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization22
Endogenous electrophiles and peroxymonocarbonate can link tyrosine phosphorylation cascades with the cytosolic TXNRD1 selenoprotein and the KEAP1/NRF2 system22
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region21
Current mechanistic understanding of intermembrane lipid trafficking important for maintenance of bacterial outer membrane lipid asymmetry21
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level21
Fluorescent indicators for imaging membrane potential of organelles21
Synthetic peptide scaffolds as ion channels and molecular carriers21
Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging20
Editorial overview: Glycobiology (2023)20
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides20
A new era of cysteine proteomics – Technological advances in thiol biology20
New frontiers in sulfur and selenium chemical biology20
The Ramifications of synthetic biology19
Editorial Board19
Activity-based protein profiling in microbes and the gut microbiome19
Publisher’s Note19
Shedding light on current trends in molecular optogenetics19
Emerging fluorescence tools for the study of proteostasis in cells19
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis19
Deciphering combinatorial post-translational modifications by top-down mass spectrometry19
Emerging roles of low-molecular-weight thiols at the host–microbe interface19
Recent advances in photoaffinity labeling strategies to capture Glycan–Protein interactions18
Recent research progress in glycosylphosphatidylinositol-anchored protein biosynthesis, chemical/chemoenzymatic synthesis, and interaction with the cell membrane18
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes17
Cytokine engineering for targeted cancer immunotherapy17
Recent progress in synthesis of carbohydrates with sugar nucleotide-dependent glycosyltransferases17
Developing photoactivated artificial enzymes for sustainable fuel production17
New strategies for fluorescently labeling proteins in the study of amyloids17
Metal complexes as optical probes for DNA sensing and imaging17
Advancements in boron difluoride formazanate dyes for biological imaging17
Transition metal catalysts for the bioorthogonal synthesis of bioactive agents17
Synthetic probes and chemical tools in sphingolipid research17
Consequences of post-translational modifications on amyloid proteins as revealed by protein semisynthesis16
Maximizing content across scales: Moving multimodal microscopy and mesoscopy toward molecular imaging16
Improved methods for targeting epigenetic reader domains of acetylated and methylated lysine16
Harnessing the power of directed evolution to improve genome editing systems16
Inhibitors of DHHC family proteins16
Extendable and explainable deep learning for pan-cancer radiogenomics research16
Deuterium Raman imaging for lipid analysis15
Compounds for selective translational inhibition15
Characteristics of genetic tags for correlative light and electron microscopy15
Caged lipid probes for controlling lipid levels on subcellular scales15
Molecular simulations of complex carbohydrates and glycoconjugates15
Engaging with benzoyllysine through a π-π-π mechanism15
Recent advances in ratiometric fluorescence imaging of enzyme activity in vivo15
Convergent and divergent biosynthetic strategies towards phosphonic acid natural products15
Promoting remyelination: A case study in regenerative medicine15
Recent progress in mass spectrometry for single-cell metabolomics15
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic15
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