OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Chemical Biology is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Fluorogenic polymethine dyes by intramolecular cyclization	152
Small-molecule modulators of protein–RNA interactions	79
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes	76
Engineered metallobiocatalysts for energy–relevant reactions	75
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	67
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	64
Imaging of proteases using activity-based probes	60
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	60
Glycoengineering in antigen-specific immunotherapies	58
Editorial Board	54
Activity-based protein profiling in microbes and the gut microbiome	53
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	51
The Ramifications of synthetic biology	51
Synthetic transporters for oxoanions	51
Caged lipid probes for controlling lipid levels on subcellular scales	50
Site-specific bioconjugation and nuclear imaging	49
Recent advances in methods for quantifying the cell penetration of macromolecules	48
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	46
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications	45
Extendable and explainable deep learning for pan-cancer radiogenomics research	44
Characteristics of genetic tags for correlative light and electron microscopy	43
Chemical inhibitors of transcription-associated kinases	42
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	41
Genetically encoded fluorescent sensors for metals in biology	41
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	41

Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	40
Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	39
Advances in the understanding and exploitation of carbohydrate-active enzymes	38
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	37
Chemistry and biology of enzymes in protein glutathionylation	37
Highlighting the roles of transition metals and speciation in chemical biology	37
Editorial Board	37
Critical considerations in N-glycoproteomics	37
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	36
Editorial Board	36
Super-multiplexed vibrational probes: Being colorful makes a difference	36
Natural and engineered precision antibiotics in the context of resistance	36
Mechanism and inhibition of BRAF kinase	35
How nature incorporates sulfur and selenium into bioactive natural products	35
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	34
Editorial: Unusual enzyme reactions in natural products biosynthesis	33
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	33
Virus-assisted directed evolution of biomolecules	33
Sulfoxides in medicine	32
Recent progress of TP/NIR fluorescent probes for metal ions	32
Recent advances in computational algorithms and software for large-scale glycoproteomics	32
Cysteine and methionine oxidation in thrombotic disorders	31
Targeted protein degradation: Emerging concepts and protein state-specific targeting principles	31
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	31
Transferring enzyme features to molecular CO2 reduction catalysts	30
Recent advances in N- and C-terminus cysteine protein bioconjugation	30
Bacterial peptidoglycan as a living polymer	30
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	29
Synthetic peptide scaffolds as ion channels and molecular carriers	29
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	28
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	28
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	28
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	28
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	27
Synthesis and application of bacterial exopolysaccharides	26
Molecular glues to stabilise protein–protein interactions	26
SOD mimics: From the tool box of the chemists to cellular studies	26
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	26
Promoting remyelination: A case study in regenerative medicine	25
Fluorescent indicators for imaging membrane potential of organelles	25
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	25
New frontiers in sulfur and selenium chemical biology	25
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	25
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	24
Editorial overview: Recent advances in metabolomics	24
Editorial overview: Glycobiology (2024)	24
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	24
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport	24
Analytical techniques in chemical biology	23
Editorial Board	23

Metalloprotein enabled redox signal transduction in microbes	23
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	23
Editorial Board	23
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	23
Protein-based models offer mechanistic insight into complex nickel metalloenzymes	23
Editorial overview: Synthetic biomolecules for probing lipid membranes	23
Editorial Board	23
Lipidomics analysis in drug discovery and development	23
Sensing and regulation of reactive sulfur species (RSS) in bacteria	22
Catalyzing the future: recent advances in chemical synthesis using enzymes	22
Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141	22
Glutathione dynamics in subcellular compartments and implications for drug development	22
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	22
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	22
Discovery and evolution of [4 + 2] cyclases	21
Recent progress on small molecules targeting epigenetic complexes	21
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems	21
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	21
Editorial: Mechanistic biology	20
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	20
Small-molecule tools for YEATS domain proteins	20
Strategies in engineering sustainable biochemical synthesis through microbial systems	20
Editorial Board	20
Chemical synthesis and biological functions of carbohydrates	20
Targeting chemotherapy-resistant tumour sub-populations using inorganic chemistry: Anti-cancer stem cell metal complexes	20
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	20
The non-catalytic domains of O-GlcNAc cycling enzymes present new opportunities for function-specific control	20
Recent advances in high-throughput screening methods for small molecule modulators in bacteria	20
Recent strides in macromolecular targeted photodynamic therapy for cancer	20