OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Chemical Biology is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?	224
Machine learning in protein structure prediction	142
Biocatalysis in drug discovery and development	107
Single-cell protein analysis by mass spectrometry	106
Protein immobilization technology for flow biocatalysis	98
Recent advances of thiol-selective bioconjugation reactions	93
Emerging strategies for expanding the toolbox of enzymes in biocatalysis	87
Protein sequence design with deep generative models	86
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment	80
Recent developments in bioorthogonal chemistry and the orthogonality within	77
Targeted protein degradation: current and future challenges	75
Bacterial enzymes for lignin depolymerisation: new biocatalysts for generation of renewable chemicals from biomass	75
Transition metal catalysts for the bioorthogonal synthesis of bioactive agents	71
Activity- and reactivity-based proteomics: Recent technological advances and applications in drug discovery	70
Recent achievements and current trajectories of diversity-oriented synthesis	69
Pictet–Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis	66
Recent progress in the development of organometallics for the treatment of cancer	65
Integrating biocatalysis with chemocatalysis for selective transformations	63
The blind men and the filament: Understanding structures and functions of microbial nanowires	62
Metabolic engineering strategies toward production of biofuels	59
Intrinsically disordered proteins and biomolecular condensates as drug targets	58
Image-based cell phenotyping with deep learning	57
How synthetic biology can help bioremediation	54
Targeting Son of Sevenless 1: The pacemaker of KRAS	53
Structure-based protein design with deep learning	53

Advances of epigenetic editing	53
Inhibitors of the mitochondrial calcium uniporter for the treatment of disease	50
Mammalian iron–sulfur cluster biogenesis: Recent insights into the roles of frataxin, acyl carrier protein and ATPase-mediated transfer to recipient proteins	49
Anatomy of a crosslinker	48
Recent advances in the chemoenzymatic synthesis of bioactive natural products	48
Siglec and anti-Siglec therapies	47
Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery	46
Proteolysis targeting chimeras (PROTACs) for epigenetics research	45
The rise of covalent proteolysis targeting chimeras	45
Metalloproteomics in conjunction with other omics for uncovering the mechanism of action of metallodrugs: Mechanism-driven new therapy development	44
Exploiting azide–alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes	43
Emerging tools for bioluminescence imaging	43
BET bromodomain inhibitors	41
Protein metalation in biology	41
Gold compounds for catalysis and metal-mediated transformations in biological systems	41
Directed evolution for enzyme development in biocatalysis	41
Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics	41
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	40
Natural product discovery through microbial genome mining	39
Shewanella biofilm development and engineering for environmental and bioenergy applications	39
Domain-selective targeting of BET proteins in cancer and immunological diseases	39
Drugging histone methyltransferases in cancer	39
Iron–sulfur cluster signaling: The common thread in fungal iron regulation	39
Enzymes with noncanonical amino acids	38
Towards a more precise therapy in cancer: Exploring epigenetic complexity	38
New approaches to target RNA binding proteins	38
Recent progress on the prospective application of machine learning to structure-based virtual screening	38
Recent progress in synthesis of carbohydrates with sugar nucleotide-dependent glycosyltransferases	38
Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment	38
Supramolecular metal-based nanoparticles for drug delivery and cancer therapy	38
New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance	37
Fluorine biocatalysis	37
Cytokine engineering for targeted cancer immunotherapy	36
Recent advances in mass spectrometry–based peptidomics workflows to identify short-open-reading-frame-encoded peptides and explore their functions	36
Harnessing and engineering amide bond forming ligases for the synthesis of amides	36
Chemiluminescent spiroadamantane-1,2-dioxetanes: Recent advances in molecular imaging and biomarker detection	34
Machine learning for target discovery in drug development	34
Bacterial manganese sensing and homeostasis	34
Targeting histone acetylation/deacetylation in parasites: an update (2017–2020)	34
Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes	33
Chemical warfare between fungus-growing ants and their pathogens	33
The evolving capabilities of enzyme-mediated proximity labeling	33
Isocitrate dehydrogenase variants in cancer — Cellular consequences and therapeutic opportunities	33
Molecular mechanisms of microbial transmembrane electron transfer of electrochemically active bacteria	33
Generating orthogonal glycosyltransferase and nucleotide sugar pairs as next-generation glycobiology tools	33
SOD mimics: From the tool box of the chemists to cellular studies	33
Toward synthetic life: Biomimetic synthetic cell communication	32
Recent advance in the biosynthesis of nitrogen–nitrogen bond–containing natural products	32
Enzyme evolution in natural products biosynthesis: target- or diversity-oriented?	32
Recent progress in metal-based molecular probes for optical bioimaging and biosensing	31

Expanding the applicability of cytochrome P450s and other haemoproteins	30
Two-hit wonders: The expanding universe of multitargeting epigenetic agents	30
Engineering Clostridium ljungdahlii as the gas-fermenting cell factory for the production of biofuels and biochemicals	30
Chemical biology of protein citrullination by the protein A arginine deiminases	29
Natural, modified DNA bases	29
Current state on the enzymatic synthesis of glycosaminoglycans	29
Potential-dependent extracellular electron transfer pathways of exoelectrogens	28
Mass spectrometry techniques for imaging and detection of metallodrugs	28
Inhibitors of DHHC family proteins	28
Recent advances in drug repurposing using machine learning	28
Not so innocent: Impact of fluorophore chemistry on the in vivo properties of bioconjugates	27
Caged lipids for subcellular manipulation	26
Systems for in vivo hypermutation: a quest for scale and depth in directed evolution	26
Designer metalloenzymes for synthetic biology: Enzyme hybrids for catalysis	26
Advances in theranostic biomarkers for tumor immunotherapy	25
Photocaged functional nucleic acids for spatiotemporal imaging in biology	25
Synthetic biomolecular condensates to engineer eukaryotic cells	25
The chemical biology of hydrogen sulfide and related hydropersulfides: interactions with biologically relevant metals and metalloproteins	25
Rewiring yeast metabolism to synthesize products beyond ethanol	25
Supramolecular coordination complexes as diagnostic and therapeutic agents	25
Metallo-β-lactamases and a tug-of-war for the available zinc at the host–pathogen interface	24
Current strategies for characterization of mucin-domain glycoproteins	24
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	24
Connecting chemistry and biology through molecular descriptors	24
Metal complexes as optical probes for DNA sensing and imaging	24
Exploring amyloid oligomers with peptide model systems	23
Revealing the functional roles of tyrosine sulfation using synthetic sulfopeptides and sulfoproteins	23
Biogenesis of the peptide-derived redox cofactor pyrroloquinoline quinone	23
Non-conventional hosts for the production of fuels and chemicals	22
Adenosylation reactions catalyzed by the radical S-adenosylmethionine superfamily enzymes	22
Recent progress in chemical synthesis of bacterial surface glycans	22
Imaging organelle membranes in live cells at the nanoscale with lipid-based fluorescent probes	22
Enhancing native chemical ligation for challenging chemical protein syntheses	21
Advanced functional fluorescent probes for cell plasma membranes	21
Deciphering combinatorial post-translational modifications by top-down mass spectrometry	21
Zinc homeostasis in the secretory pathway in yeast	21
Enzyme-targeted fluorescent small-molecule probes for bacterial imaging	21
New strategies for fluorescently labeling proteins in the study of amyloids	21
Synthetic biology for natural product drug production and engineering	21
Chemical synthesis of polysaccharides	20
Targeting epigenetic reader domains by chemical biology	20
In silico, in vitro, and in vivo machine learning in synthetic biology and metabolic engineering	20
Current processes and future challenges of photoautotrophic production of acetyl-CoA-derived solar fuels and chemicals in cyanobacteria	20
Imaging voltage and brain chemistry with genetically encoded sensors and modulators	20
Biosynthesis of marine toxins	20
Acoustic-based chemical tools for profiling the tumor microenvironment	20
Engineered biosynthetic pathways and biocatalytic cascades for sustainable synthesis	20
All-atom simulations to studying metallodrugs/target interactions	19
Natural and engineered transglycosylases: Green tools for the enzyme-based synthesis of glycoproducts	19
Reducing the renal retention of low- to moderate-molecular-weight radiopharmaceuticals	19
Sensing cellular biochemistry with fluorescent chemical–genetic hybrids	19
Strategies and open questions in solid-phase protein chemical synthesis	19
Catalytic amyloids: Is misfolding folding?	19
Tailoring microbes to upgrade lignin	19