OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Chemical Biology is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Machine learning in protein structure prediction	168
Single-cell protein analysis by mass spectrometry	122
Protein sequence design with deep generative models	104
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment	93
Recent developments in bioorthogonal chemistry and the orthogonality within	92
Transition metal catalysts for the bioorthogonal synthesis of bioactive agents	84
Activity- and reactivity-based proteomics: Recent technological advances and applications in drug discovery	79
Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics	78
Metabolic engineering strategies toward production of biofuels	74
Intrinsically disordered proteins and biomolecular condensates as drug targets	71
Image-based cell phenotyping with deep learning	70
The blind men and the filament: Understanding structures and functions of microbial nanowires	67
Structure-based protein design with deep learning	67
Targeting Son of Sevenless 1: The pacemaker of KRAS	60
BET bromodomain inhibitors	58
Siglec and anti-Siglec therapies	57
Protein metalation in biology	54
Anatomy of a crosslinker	53
Emerging tools for bioluminescence imaging	51
Chemiluminescent spiroadamantane-1,2-dioxetanes: Recent advances in molecular imaging and biomarker detection	49
Directed evolution for enzyme development in biocatalysis	48
The rise of covalent proteolysis targeting chimeras	48
SOD mimics: From the tool box of the chemists to cellular studies	47
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	46
Natural product discovery through microbial genome mining	46

New approaches to target RNA binding proteins	45
Recent progress on the prospective application of machine learning to structure-based virtual screening	45
New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance	44
Recent progress in synthesis of carbohydrates with sugar nucleotide-dependent glycosyltransferases	44
Cytokine engineering for targeted cancer immunotherapy	43
Shewanella biofilm development and engineering for environmental and bioenergy applications	43
Current state on the enzymatic synthesis of glycosaminoglycans	41
Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment	41
Enzyme evolution in natural products biosynthesis: target- or diversity-oriented?	40
Recent advances in mass spectrometry–based peptidomics workflows to identify short-open-reading-frame-encoded peptides and explore their functions	40
Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes	39
Supramolecular metal-based nanoparticles for drug delivery and cancer therapy	39
Molecular mechanisms of microbial transmembrane electron transfer of electrochemically active bacteria	39
Recent progress in metal-based molecular probes for optical bioimaging and biosensing	38
Chemical warfare between fungus-growing ants and their pathogens	37
Recent advances in drug repurposing using machine learning	36
Potential-dependent extracellular electron transfer pathways of exoelectrogens	35
Recent advance in the biosynthesis of nitrogen–nitrogen bond–containing natural products	35
Toward synthetic life: Biomimetic synthetic cell communication	35
Connecting chemistry and biology through molecular descriptors	34
Expanding the applicability of cytochrome P450s and other haemoproteins	34
Engineering Clostridium ljungdahlii as the gas-fermenting cell factory for the production of biofuels and biochemicals	34
Advanced functional fluorescent probes for cell plasma membranes	34
Generating orthogonal glycosyltransferase and nucleotide sugar pairs as next-generation glycobiology tools	34
The evolving capabilities of enzyme-mediated proximity labeling	34
Mass spectrometry techniques for imaging and detection of metallodrugs	33
Systems for in vivo hypermutation: a quest for scale and depth in directed evolution	32
Inhibitors of DHHC family proteins	32
Rewiring yeast metabolism to synthesize products beyond ethanol	31
Molecular simulations of complex carbohydrates and glycoconjugates	31
Emerging chelators for nuclear imaging	31
Supramolecular coordination complexes as diagnostic and therapeutic agents	31
Chemical biology of protein citrullination by the protein A arginine deiminases	30
Not so innocent: Impact of fluorophore chemistry on the in vivo properties of bioconjugates	30
Biogenesis of the peptide-derived redox cofactor pyrroloquinoline quinone	30
Synthetic biomolecular condensates to engineer eukaryotic cells	30
Current strategies for characterization of mucin-domain glycoproteins	30
Caged lipids for subcellular manipulation	30
Metal complexes as optical probes for DNA sensing and imaging	28
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	28
Quantitative interactome analysis with chemical cross-linking and mass spectrometry	28
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	27
Reducing the renal retention of low- to moderate-molecular-weight radiopharmaceuticals	27
Metallo-β-lactamases and a tug-of-war for the available zinc at the host–pathogen interface	27
All-atom simulations to studying metallodrugs/target interactions	26
Deciphering combinatorial post-translational modifications by top-down mass spectrometry	26
Spatial metabolomics principles and application to cancer research	26
Critical considerations in N-glycoproteomics	26
Chemical synthesis of polysaccharides	25
Non-conventional hosts for the production of fuels and chemicals	25

Molecular probes for fluorescence image-guided cancer surgery	25
Exploring amyloid oligomers with peptide model systems	25
Characterising biomolecular interactions and dynamics with mass photometry	24
Recent advances in mass spectrometry-based computational metabolomics	24
Imaging organelle membranes in live cells at the nanoscale with lipid-based fluorescent probes	24
Biosynthesis of marine toxins	24
Catalytic amyloids: Is misfolding folding?	23
Emerging frontiers in virtual drug discovery: From quantum mechanical methods to deep learning approaches	23
Substrates and interactors of the ClpP protease in the mitochondria	23
Photoaffinity labeling approaches to elucidate lipid–protein interactions	23
New strategies for fluorescently labeling proteins in the study of amyloids	23
In silico, in vitro, and in vivo machine learning in synthetic biology and metabolic engineering	22
Beyond mere DNA damage: Recent progress in platinum(IV) anticancer complexes containing multi-functional axial ligands	22
Natural and engineered transglycosylases: Green tools for the enzyme-based synthesis of glycoproducts	22
Versatile signaling mechanisms of inositol pyrophosphates	22
Tailoring microbes to upgrade lignin	22
Genetically encoding latent bioreactive amino acids and the development of covalent protein drugs	22
From structure to application: Progress and opportunities in peptide materials development	21
Current processes and future challenges of photoautotrophic production of acetyl-CoA-derived solar fuels and chemicals in cyanobacteria	21
Bromodomain inhibitors and therapeutic applications	21
Highlighting the roles of transition metals and speciation in chemical biology	20
Molecular glues to stabilise protein–protein interactions	20
Chemogenetic and optogenetic control of post-translational modifications through genetic code expansion	20
New strategies to identify protease substrates	20
Understanding and controlling amyloid aggregation with chirality	20
Recent advances in polysaccharide-based in situ forming hydrogels	20
Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo	19
Emerging roles of O-glycosylation in regulating protein aggregation, phase separation, and functions	19
Sulfoxides in medicine	19
Phospholipid-coated targeted microbubbles for ultrasound molecular imaging and therapy	19
Past, present, and perspectives of protein N-terminal methylation	19
Mechanosensitive channels of Corynebacterium glutamicum functioning as exporters of l-glutamate and other valuable metabolites	18
Metal-based environment-sensitive MRI contrast agents	18
Peptides for disrupting and degrading amyloids	18
Mitochondria as a target of third row transition metal-based anticancer complexes	18
Chemical regulation of the cGAS-STING pathway	18
A critical evaluation of probes for cysteine sulfenic acid	18
Promising heterometallic compounds as anticancer agents: Recent studies in vivo	18
Mapping messenger RNA methylations at single base resolution	17
Stereo-electronic control of reaction selectivity in short-chain dehydrogenases: Decarboxylation, epimerization, and dehydration	17
Application of X-ray absorption and X-ray fluorescence techniques to the study of metallodrug action	17
Inhibition of p53 protein aggregation as a cancer treatment strategy	17
Deuterium Raman imaging for lipid analysis	17
Emerging role of ferrous iron in bacterial growth and host–pathogen interaction: New tools for chemical (micro)biology and antibacterial therapy	17
Methods to identify protein targets of metal-based drugs	17
Small-angle X-ray scattering studies of enzymes	17