OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Chemical Biology is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics	168
Single-cell protein analysis by mass spectrometry	122
Recent advances in drug repurposing using machine learning	104
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	93
Natural and engineered transglycosylases: Green tools for the enzyme-based synthesis of glycoproducts	92
New analytical methods focusing on polar metabolite analysis in mass spectrometry and NMR-based metabolomics	84
Decoding the cellular effects of genetic variation through interaction proteomics	83
Peptides for disrupting and degrading amyloids	79
Direct visualization and profiling of protein misfolding and aggregation in live cells	77
Supramolecular coordination complexes as diagnostic and therapeutic agents	71
Chemical biology tools for imaging-based analysis of organelle membranes and lipids	67
Editorial Board	60
Covalent labeling of immune cells	58
Small-molecule modulators of protein–RNA interactions	57
Imaging organelle membranes in live cells at the nanoscale with lipid-based fluorescent probes	54
Development of effective therapeutics for polysubstance use disorders	53
NMR spectroscopy to study the fate of metallodrugs in cells	51
Programmable tools for targeted analysis of epigenetic DNA modifications	49
The evolving capabilities of enzyme-mediated proximity labeling	48
Luminescent lanthanide probes for cations and anions: Promises, compromises, and caveats	48
Editorial Board	47
Fluorogenic polymethine dyes by intramolecular cyclization	46
Editorial overview: Imaging metal ions in biological systems	46
Tuning specificity and topology of lectins through synthetic biology	45
Synthesis and application of bacterial exopolysaccharides	45

Editorial Board	44
Small molecule fluorescent probes for the study of protein phase separation	44
Enzymatic strategies for selenium incorporation into biological molecules	43
Recent progresses in the cyclization and oxidation of polyketide biosynthesis	41
How are hydrogen peroxide messages relayed to affect cell signalling?	41
Recent advances in the design and optimization of artificial metalloenzymes	40
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	39
MicroRNA:Siglec crosstalk in cancer progression	39
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	38
Activity-based probes in pathogenic bacteria: Investigating drug targets and molecule specificity	38
Recent advances in developing degraders & inhibitors of lysine methyltransferases	36
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	35
Recent advances in induced proximity modalities	34
Promising heterometallic compounds as anticancer agents: Recent studies in vivo	34
Small-angle X-ray scattering studies of enzymes	34
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	33
In silico, in vitro, and in vivo machine learning in synthetic biology and metabolic engineering	32
Bacterial peptidoglycan as a living polymer	32
Towards sequence-based principles for protein phase separation predictions	31
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	31
Electrophilic metabolites targeting the KEAP1/NRF2 partnership	31
Chemical tools targeting readers of lysine methylation	30
Editorial overview: Systems biology and the rise and rise of omics approaches	30
Sulfur-containing marine natural products as leads for drug discovery and development	30
Recent advances in mass spectrometry–based peptidomics workflows to identify short-open-reading-frame-encoded peptides and explore their functions	30
Toward synthetic life: Biomimetic synthetic cell communication	30
Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles	28
Imaging of proteases using activity-based probes	28
New chemical processes to streamline carbohydrate synthesis	28
SOD mimics: From the tool box of the chemists to cellular studies	27
Exploring amyloid oligomers with peptide model systems	27
Comments on ‘A critical evaluation of probes for cysteine sulfenic acid’	27
Probing immune infiltration dynamics in cancer by in vivo imaging	27
Strategies and mechanisms for endosomal escape of therapeutic nucleic acids	26
Emerging frontiers in virtual drug discovery: From quantum mechanical methods to deep learning approaches	26
Biochemistry of the hypoxia-inducible factor hydroxylases	26
An expanded molecular and systems toolbox for imaging, mapping, and controlling local translation	26
Glycoengineering in antigen-specific immunotherapies	26
Drugging the undruggable proteins in cancer: A systems biology approach	25
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	25
Advanced functional fluorescent probes for cell plasma membranes	25
The chemical biology of NAD+ regulation in axon degeneration	24
Molecular glues to stabilise protein–protein interactions	24
Chemical regulation of the cGAS-STING pathway	24
Role of conformational dynamics in pathogenic protein aggregation	24
Recent advances in intravital microscopy for preclinical research	23
Recent advances in data- and knowledge-driven approaches to explore primary microbial metabolism	23
Recent progress in metal-based molecular probes for optical bioimaging and biosensing	23
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	23
Characterising biomolecular interactions and dynamics with mass photometry	22

From structure to application: Progress and opportunities in peptide materials development	22
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	22
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	21
Mass spectrometry techniques for imaging and detection of metallodrugs	21
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level	20
Endogenous electrophiles and peroxymonocarbonate can link tyrosine phosphorylation cascades with the cytosolic TXNRD1 selenoprotein and the KEAP1/NRF2 system	20
Corrigendum to “Shedding light on complexity of protein–protein interactions in cancer” [Curr Opin Chem Biol 53 (2019) 75-81]	20
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	20
Microbial metabolite-receptor interactions in the gut microbiome	20
Inhibitors of DHHC family proteins	20
Synthetic peptide scaffolds as ion channels and molecular carriers	20
Engineered metallobiocatalysts for energy–relevant reactions	20
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region	19
Current mechanistic understanding of intermembrane lipid trafficking important for maintenance of bacterial outer membrane lipid asymmetry	19
Fluorescent indicators for imaging membrane potential of organelles	19
A new era of cysteine proteomics – Technological advances in thiol biology	19
Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging	19
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	19
Chemical and optical control of CRISPR-associated nucleases	18
New strategies for fluorescently labeling proteins in the study of amyloids	18
Extendable and explainable deep learning for pan-cancer radiogenomics research	18
Recent advances in photoaffinity labeling strategies to capture Glycan–Protein interactions	18
Sulfur-containing peptides: Synthesis and application in the discovery of potential drug candidates	18
Cytokine engineering for targeted cancer immunotherapy	18
Consequences of post-translational modifications on amyloid proteins as revealed by protein semisynthesis	18
Transition metal catalysts for the bioorthogonal synthesis of bioactive agents	17
Shedding light on current trends in molecular optogenetics	17
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	17
Recent research progress in glycosylphosphatidylinositol-anchored protein biosynthesis, chemical/chemoenzymatic synthesis, and interaction with the cell membrane	17
Recent progress in synthesis of carbohydrates with sugar nucleotide-dependent glycosyltransferases	17
Emerging fluorescence tools for the study of proteostasis in cells	17
Generating orthogonal glycosyltransferase and nucleotide sugar pairs as next-generation glycobiology tools	17
New frontiers in sulfur and selenium chemical biology	16
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis	16
Editorial overview: Glycobiology (2023)	16
Recent advances in ratiometric fluorescence imaging of enzyme activity in vivo	16
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides	16
Synthetic probes and chemical tools in sphingolipid research	15
Engaging with benzoyllysine through a π-π-π mechanism	15
Editorial Board	15
The Ramifications of synthetic biology	15
Convergent and divergent biosynthetic strategies towards phosphonic acid natural products	15
Recent progress in mass spectrometry for single-cell metabolomics	15
Harnessing the power of directed evolution to improve genome editing systems	15
Editorial Board	15
Promoting remyelination: A case study in regenerative medicine	15
Publisher’s Note	15
Improved methods for targeting epigenetic reader domains of acetylated and methylated lysine	15