OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Chemical Biology is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Corrigendum to “Shedding light on complexity of protein–protein interactions in cancer” [Curr Opin Chem Biol 53 (2019) 75-81]	187
Small-molecule modulators of protein–RNA interactions	121
Fluorogenic polymethine dyes by intramolecular cyclization	107
Glycoengineering in antigen-specific immunotherapies	98
Engineered metallobiocatalysts for energy–relevant reactions	85
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	85
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	83
Imaging of proteases using activity-based probes	74
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	69
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	67
Synthetic transporters for oxoanions	66
Caged lipid probes for controlling lipid levels on subcellular scales	60
Site-specific bioconjugation and nuclear imaging	57
Extendable and explainable deep learning for pan-cancer radiogenomics research	55
New strategies for fluorescently labeling proteins in the study of amyloids	54
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	54
Recent advances in methods for quantifying the cell penetration of macromolecules	53
The Ramifications of synthetic biology	53
Characteristics of genetic tags for correlative light and electron microscopy	50
Activity-based protein profiling in microbes and the gut microbiome	49
Chemical inhibitors of transcription-associated kinases	48
Past, present, and perspectives of protein N-terminal methylation	47
Chemistry and biology of enzymes in protein glutathionylation	47
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	44
Critical considerations in N-glycoproteomics	42

Chemical probes for tagging mycobacterial lipids	42
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	42
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	41
Genetically encoded fluorescent sensors for metals in biology	38
Highlighting the roles of transition metals and speciation in chemical biology	37
Advances in the understanding and exploitation of carbohydrate-active enzymes	36
Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	36
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	36
Chemical engineering of bacterial effectors for regulating cell signaling and responses	36
Editorial Board	35
Editorial Board	35
Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF	35
Understanding and controlling amyloid aggregation with chirality	35
Super-multiplexed vibrational probes: Being colorful makes a difference	34
How nature incorporates sulfur and selenium into bioactive natural products	34
Natural and engineered precision antibiotics in the context of resistance	34
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	33
Emerging tools for bioluminescence imaging	33
Protein sequence design with deep generative models	33
Chemical approaches for investigating site-specific protein S-fatty acylation	33
Mechanism and inhibition of BRAF kinase	32
A chemical field guide to histone nonenzymatic modifications	31
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	31
Induced proximity tools for precise manipulation of lipid signaling	31
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	30
Catalytic amyloids: Is misfolding folding?	30
Recent progress of TP/NIR fluorescent probes for metal ions	30
Recent advances in computational algorithms and software for large-scale glycoproteomics	30
Reducing the renal retention of low- to moderate-molecular-weight radiopharmaceuticals	29
Sulfoxides in medicine	29
Virus-assisted directed evolution of biomolecules	29
Targeting Son of Sevenless 1: The pacemaker of KRAS	29
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	28
Chemoenzymatic strategies for RNA modification and labeling	28
Emerging mammalian gene switches for controlling implantable cell therapies	27
Cysteine and methionine oxidation in thrombotic disorders	27
Recent advances in N- and C-terminus cysteine protein bioconjugation	27
Transferring enzyme features to molecular CO2 reduction catalysts	27
Targeted protein degradation: Emerging concepts and protein state-specific targeting principles	26
New approaches to target RNA binding proteins	26
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	25
Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment	25
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	25
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	25
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	24
Molecular glues to stabilise protein–protein interactions	24
Bacterial peptidoglycan as a living polymer	24
SOD mimics: From the tool box of the chemists to cellular studies	24
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	23
Synthesis and application of bacterial exopolysaccharides	23

Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	23
Exploring amyloid oligomers with peptide model systems	22
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	22
Synthetic peptide scaffolds as ion channels and molecular carriers	22
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	21
Fluorescent indicators for imaging membrane potential of organelles	21
Peptides for disrupting and degrading amyloids	21
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	21
New frontiers in sulfur and selenium chemical biology	21
Inhibitors of DHHC family proteins	21
Promoting remyelination: A case study in regenerative medicine	21
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	21
Advancements in chemical biology targeting the kinases and phosphatases of RNA polymerase II-mediated transcription	20
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	20
Engineering the bilayer: Emerging genetic tool kits for mechanistic lipid biology	20
Lipidomics analysis in drug discovery and development	20
Glutathione dynamics in subcellular compartments and implications for drug development	20
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	20
Protein-based models offer mechanistic insight into complex nickel metalloenzymes	19
Editorial Board	19
Editorial overview: Amyloid-inspired synthetic biomolecules	19
Analytical techniques in chemical biology	19
Editorial overview: Synthetic biomolecules for probing lipid membranes	19
Metalloprotein enabled redox signal transduction in microbes	19
Editorial Board	19
Editorial Board	19
Editorial overview: Recent advances in metabolomics	18
Image-based cell phenotyping with deep learning	18
Editorial Board	18
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment	18
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	18
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	18
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	18
Sensing and regulation of reactive sulfur species (RSS) in bacteria	18
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	18
Catalyzing the future: recent advances in chemical synthesis using enzymes	18
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	17
Editorial: Mechanistic biology	17
Recent advances in the mass spectrometric profiling of bacterial lipids	17
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	17
Discovery and evolution of [4 + 2] cyclases	17
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	17