Current Opinion in Chemical Biology

Article	Citations
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics	168
Single-cell protein analysis by mass spectrometry	122
Recent advances in drug repurposing using machine learning	104
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	93
Natural and engineered transglycosylases: Green tools for the enzyme-based synthesis of glycoproducts	92
New analytical methods focusing on polar metabolite analysis in mass spectrometry and NMR-based metabolomics	84
Decoding the cellular effects of genetic variation through interaction proteomics	83
Peptides for disrupting and degrading amyloids	79
Direct visualization and profiling of protein misfolding and aggregation in live cells	77
Supramolecular coordination complexes as diagnostic and therapeutic agents	71
Chemical biology tools for imaging-based analysis of organelle membranes and lipids	67
Editorial Board	60
Covalent labeling of immune cells	58
Small-molecule modulators of protein–RNA interactions	57
Imaging organelle membranes in live cells at the nanoscale with lipid-based fluorescent probes	54
Development of effective therapeutics for polysubstance use disorders	53
NMR spectroscopy to study the fate of metallodrugs in cells	51
Programmable tools for targeted analysis of epigenetic DNA modifications	49
The evolving capabilities of enzyme-mediated proximity labeling	48
Luminescent lanthanide probes for cations and anions: Promises, compromises, and caveats	48
Editorial Board	47
Fluorogenic polymethine dyes by intramolecular cyclization	46
Editorial overview: Imaging metal ions in biological systems	46
Tuning specificity and topology of lectins through synthetic biology	45
Synthesis and application of bacterial exopolysaccharides	45

Editorial Board	44
Small molecule fluorescent probes for the study of protein phase separation	44
Enzymatic strategies for selenium incorporation into biological molecules	43
Recent progresses in the cyclization and oxidation of polyketide biosynthesis	41
How are hydrogen peroxide messages relayed to affect cell signalling?	41
Recent advances in the design and optimization of artificial metalloenzymes	40
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	39
MicroRNA:Siglec crosstalk in cancer progression	39
Activity-based probes in pathogenic bacteria: Investigating drug targets and molecule specificity	38
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	38
Recent advances in developing degraders & inhibitors of lysine methyltransferases	36
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	35
Promising heterometallic compounds as anticancer agents: Recent studies in vivo	34
Small-angle X-ray scattering studies of enzymes	34
Recent advances in induced proximity modalities	34
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	33
Bacterial peptidoglycan as a living polymer	32
In silico, in vitro, and in vivo machine learning in synthetic biology and metabolic engineering	32
Towards sequence-based principles for protein phase separation predictions	31
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	31
Electrophilic metabolites targeting the KEAP1/NRF2 partnership	31
Chemical tools targeting readers of lysine methylation	30
Editorial overview: Systems biology and the rise and rise of omics approaches	30
Sulfur-containing marine natural products as leads for drug discovery and development	30
Recent advances in mass spectrometry–based peptidomics workflows to identify short-open-reading-frame-encoded peptides and explore their functions	30
Toward synthetic life: Biomimetic synthetic cell communication	30
Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles	28
Imaging of proteases using activity-based probes	28
New chemical processes to streamline carbohydrate synthesis	28
SOD mimics: From the tool box of the chemists to cellular studies	27
Exploring amyloid oligomers with peptide model systems	27
Comments on ‘A critical evaluation of probes for cysteine sulfenic acid’	27
Probing immune infiltration dynamics in cancer by in vivo imaging	27
Biochemistry of the hypoxia-inducible factor hydroxylases	26
An expanded molecular and systems toolbox for imaging, mapping, and controlling local translation	26
Glycoengineering in antigen-specific immunotherapies	26
Strategies and mechanisms for endosomal escape of therapeutic nucleic acids	26
Emerging frontiers in virtual drug discovery: From quantum mechanical methods to deep learning approaches	26
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	25
Advanced functional fluorescent probes for cell plasma membranes	25
Drugging the undruggable proteins in cancer: A systems biology approach	25
Molecular glues to stabilise protein–protein interactions	24
Chemical regulation of the cGAS-STING pathway	24
Role of conformational dynamics in pathogenic protein aggregation	24
The chemical biology of NAD+ regulation in axon degeneration	24
Recent advances in data- and knowledge-driven approaches to explore primary microbial metabolism	23
Recent progress in metal-based molecular probes for optical bioimaging and biosensing	23
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	23
Recent advances in intravital microscopy for preclinical research	23
From structure to application: Progress and opportunities in peptide materials development	22

Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	22
Characterising biomolecular interactions and dynamics with mass photometry	22
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	21
Mass spectrometry techniques for imaging and detection of metallodrugs	21
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level	20
Endogenous electrophiles and peroxymonocarbonate can link tyrosine phosphorylation cascades with the cytosolic TXNRD1 selenoprotein and the KEAP1/NRF2 system	20
Corrigendum to “Shedding light on complexity of protein–protein interactions in cancer” [Curr Opin Chem Biol 53 (2019) 75-81]	20
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	20
Microbial metabolite-receptor interactions in the gut microbiome	20
Inhibitors of DHHC family proteins	20
Synthetic peptide scaffolds as ion channels and molecular carriers	20
Engineered metallobiocatalysts for energy–relevant reactions	20
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	19
Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging	19
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region	19
Current mechanistic understanding of intermembrane lipid trafficking important for maintenance of bacterial outer membrane lipid asymmetry	19
Fluorescent indicators for imaging membrane potential of organelles	19
A new era of cysteine proteomics – Technological advances in thiol biology	19
Extendable and explainable deep learning for pan-cancer radiogenomics research	18
Recent advances in photoaffinity labeling strategies to capture Glycan–Protein interactions	18
Sulfur-containing peptides: Synthesis and application in the discovery of potential drug candidates	18
Cytokine engineering for targeted cancer immunotherapy	18
Consequences of post-translational modifications on amyloid proteins as revealed by protein semisynthesis	18
Chemical and optical control of CRISPR-associated nucleases	18
New strategies for fluorescently labeling proteins in the study of amyloids	18
Recent research progress in glycosylphosphatidylinositol-anchored protein biosynthesis, chemical/chemoenzymatic synthesis, and interaction with the cell membrane	17
Recent progress in synthesis of carbohydrates with sugar nucleotide-dependent glycosyltransferases	17
Emerging fluorescence tools for the study of proteostasis in cells	17
Generating orthogonal glycosyltransferase and nucleotide sugar pairs as next-generation glycobiology tools	17
Transition metal catalysts for the bioorthogonal synthesis of bioactive agents	17
Shedding light on current trends in molecular optogenetics	17
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	17
Editorial overview: Glycobiology (2023)	16
Recent advances in ratiometric fluorescence imaging of enzyme activity in vivo	16
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides	16
New frontiers in sulfur and selenium chemical biology	16
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis	16
Editorial Board	15
Promoting remyelination: A case study in regenerative medicine	15
Publisher’s Note	15
Improved methods for targeting epigenetic reader domains of acetylated and methylated lysine	15
Synthetic probes and chemical tools in sphingolipid research	15
Engaging with benzoyllysine through a π-π-π mechanism	15
Editorial Board	15
The Ramifications of synthetic biology	15
Convergent and divergent biosynthetic strategies towards phosphonic acid natural products	15
Recent progress in mass spectrometry for single-cell metabolomics	15
Harnessing the power of directed evolution to improve genome editing systems	15
Characteristics of genetic tags for correlative light and electron microscopy	14
Emerging roles of low-molecular-weight thiols at the host–microbe interface	14
Molecular simulations of complex carbohydrates and glycoconjugates	14
Deciphering combinatorial post-translational modifications by top-down mass spectrometry	14
Maximizing content across scales: Moving multimodal microscopy and mesoscopy toward molecular imaging	14
Deuterium Raman imaging for lipid analysis	14
Activity-based protein profiling in microbes and the gut microbiome	14
Recent advances on human milk oligosaccharide antimicrobial activity	14
Caged lipid probes for controlling lipid levels on subcellular scales	14
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	13
Current insights into the role of citrullination in thrombosis	13
Site-specific bioconjugation and nuclear imaging	13
Chemical inhibitors of transcription-associated kinases	13
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	13
Advancements in boron difluoride formazanate dyes for biological imaging	13
Recent antibacterial carbohydrate-based prodrugs, drugs and delivery systems to overcome antimicrobial resistance	13
Synthetic ion channels made of DNA	12
Chemiluminescent spiroadamantane-1,2-dioxetanes: Recent advances in molecular imaging and biomarker detection	12
Foldamer-mediated transport across phospholipid bilayers	12
Compounds for selective translational inhibition	12
Metal complexes as optical probes for DNA sensing and imaging	12
Recent advances in methods for quantifying the cell penetration of macromolecules	12
Synthetic transporters for oxoanions	12
Developing photoactivated artificial enzymes for sustainable fuel production	12
Bacterial glycoengineering: Cell-based and cell-free routes for producing biopharmaceuticals with customized glycosylation	12
BET bromodomain inhibitors	12
Thermal proteome profiling: Insights into protein modifications, associations, and functions	11
Activity-based bioluminescence probes for in vivo sensing applications	11
Catalyzing the future: recent advances in chemical synthesis using enzymes	11
Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies	11
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	11
Development of novel indicators and molecular systems for calcium sensing through protein engineering	11

Glutathione dynamics in subcellular compartments and implications for drug development	11
Recent advances in the expanding genetic code	11
Supramolecular metal-based nanoparticles for drug delivery and cancer therapy	11
Chemical probes for tagging mycobacterial lipids	11
Substrates and interactors of the ClpP protease in the mitochondria	11
Advances in the understanding and exploitation of carbohydrate-active enzymes	11
Engineering novel adeno-associated viruses (AAVs) for improved delivery in the nervous system	11
Editorial overview: Recent advances in metabolomics	10
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	10
Oxygen-transfer reactions by enzymatic flavin-N5 oxygen adducts—Oxidation is not a must	10
Siglec and anti-Siglec therapies	10
The bright frontiers of microbial metabolic optogenetics	10
Recent advances in engineering microorganisms for the production of natural food colorants	10
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	10
Computational modeling of carbohydrate processing enzymes reactions	10
Recent advances in polysaccharide-based in situ forming hydrogels	10
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	10
Study of spatiotemporal regulation of kinase signaling using genetically encodable molecular tools	10
Engineering the human gut commensal Bacteroides thetaiotaomicron with synthetic biology	10
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	10
Chemistry and biology of enzymes in protein glutathionylation	10
Deconvoluting the biology and druggability of protein lipidation using chemical proteomics	10
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	10
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	10
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	10
Past, present, and perspectives of protein N-terminal methylation	9
Editorial Board	9
Editorial overview: Amyloid-inspired synthetic biomolecules	9
Molecular evolution and functional divergence of UDP-hexose 4-epimerases	9
Engineering the bilayer: Emerging genetic tool kits for mechanistic lipid biology	9
Nutritional metabolomics: Recent developments and future needs	9
Editorial Overview: Molecular synthetic biology: from understanding life to creating smart therapeutics	9
Coupling chemical biology and vibrational spectroscopy for studies of amyloids in vitro and in cells	9
The redox riddle of selenium sulfide	8
Emerging mechanisms of regulation for endoplasmic/sarcoplasmic reticulum Ca2+ stores by secretory pathway kinase FAM20C	8
Dynamics and mechanistic interpretations of nonribosomal peptide synthetase cyclization domains	8
Advancements in chemical biology targeting the kinases and phosphatases of RNA polymerase II-mediated transcription	8
Analytical techniques in chemical biology	8
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer	8
Editorial Board	8
Image-based cell phenotyping with deep learning	8
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	8
Editorial Board	8
Editorial Board	8
Sensing and regulation of reactive sulfur species (RSS) in bacteria	8
Editorial Board	8
Editorial Board	8
Beyond mere DNA damage: Recent progress in platinum(IV) anticancer complexes containing multi-functional axial ligands	8
Protein-based models offer mechanistic insight into complex nickel metalloenzymes	8
Molecular-level interplay between intrinsically disordered clients and Hsp90	8
Structural biology of proteins involved in nitrogen cycling	8
Chemical engineering of bacterial effectors for regulating cell signaling and responses	8
Editorial overview: Synthetic biomolecules for probing lipid membranes	8
Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism	8
Versatile roles of cysteine persulfides in tumor biology	8
Insights into metalloproteins and metallodrugs from electron paramagnetic resonance spectroscopy	8
Corrigendum to “Drug discovery targeting Nav1.8: Structural insights and therapeutic potential” [Curr Opin Chem Biol 83 (2024) 102538]	7
Electrogenetics: Bridging synthetic biology and electronics to remotely control the behavior of mammalian designer cells	7
Highlighting the roles of transition metals and speciation in chemical biology	7
Network analysis of genome-wide association studies for drug target prioritisation	7
Recent advances in kinase signaling network profiling by mass spectrometry	7
Forty sites of TRP channel regulation	7
New strategies to identify protease substrates	7
Metal-based environment-sensitive MRI contrast agents	7
Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	7
Genetically encoded fluorescent sensors for metals in biology	7
Corrigendum to “Compounds for selective translational inhibition” [Curr Opin Chem Biol 69 (2022) 102158]	7
Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF	7
Editorial Board	7
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	7
Critical considerations in N-glycoproteomics	6
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment	6
Chemical biology of protein citrullination by the protein A arginine deiminases	6
Peroxynitrite: a multifaceted oxidizing and nitrating metabolite	6
New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance	6
Recent advances in minimal fluorescent probes for optical imaging	6
D-Amino acid oxidase-derived chemogenetic oxidative stress: Unraveling the multi-omic responses to in vivo redox stress	6
Lipidomics analysis in drug discovery and development	6
Recent developments in bioorthogonal chemistry and the orthogonality within	6
Small molecules as modulators of phage–bacteria interactions	6
Quantitative interactome analysis with chemical cross-linking and mass spectrometry	6
Lumos maxima – How robust fluorophores resist photobleaching?	6
Metalloprotein enabled redox signal transduction in microbes	6
Prodrugs of sulfide and persulfide species: Implications in their different pharmacological activities	6
Recent progress on small molecules targeting epigenetic complexes	6
Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling	6
Current state on the enzymatic synthesis of glycosaminoglycans	6