Current Opinion in Chemical Biology

Article	Citations
Fluorogenic polymethine dyes by intramolecular cyclization	152
Small-molecule modulators of protein–RNA interactions	79
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes	76
Engineered metallobiocatalysts for energy–relevant reactions	75
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	67
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	64
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	60
Imaging of proteases using activity-based probes	60
Glycoengineering in antigen-specific immunotherapies	58
Editorial Board	54
Activity-based protein profiling in microbes and the gut microbiome	53
The Ramifications of synthetic biology	51
Synthetic transporters for oxoanions	51
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	51
Caged lipid probes for controlling lipid levels on subcellular scales	50
Site-specific bioconjugation and nuclear imaging	49
Recent advances in methods for quantifying the cell penetration of macromolecules	48
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	46
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications	45
Extendable and explainable deep learning for pan-cancer radiogenomics research	44
Characteristics of genetic tags for correlative light and electron microscopy	43
Chemical inhibitors of transcription-associated kinases	42
Genetically encoded fluorescent sensors for metals in biology	41
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	41
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	41

Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	40
Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	39
Advances in the understanding and exploitation of carbohydrate-active enzymes	38
Editorial Board	37
Critical considerations in N-glycoproteomics	37
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	37
Chemistry and biology of enzymes in protein glutathionylation	37
Highlighting the roles of transition metals and speciation in chemical biology	37
Natural and engineered precision antibiotics in the context of resistance	36
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	36
Editorial Board	36
Super-multiplexed vibrational probes: Being colorful makes a difference	36
How nature incorporates sulfur and selenium into bioactive natural products	35
Mechanism and inhibition of BRAF kinase	35
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	34
Virus-assisted directed evolution of biomolecules	33
Editorial: Unusual enzyme reactions in natural products biosynthesis	33
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	33
Recent progress of TP/NIR fluorescent probes for metal ions	32
Recent advances in computational algorithms and software for large-scale glycoproteomics	32
Sulfoxides in medicine	32
Targeted protein degradation: Emerging concepts and protein state-specific targeting principles	31
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	31
Cysteine and methionine oxidation in thrombotic disorders	31
Recent advances in N- and C-terminus cysteine protein bioconjugation	30
Bacterial peptidoglycan as a living polymer	30
Transferring enzyme features to molecular CO2 reduction catalysts	30
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	29
Synthetic peptide scaffolds as ion channels and molecular carriers	29
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	28
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	28
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	28
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	28
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	27
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	26
Synthesis and application of bacterial exopolysaccharides	26
Molecular glues to stabilise protein–protein interactions	26
SOD mimics: From the tool box of the chemists to cellular studies	26
New frontiers in sulfur and selenium chemical biology	25
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	25
Promoting remyelination: A case study in regenerative medicine	25
Fluorescent indicators for imaging membrane potential of organelles	25
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	25
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport	24
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	24
Editorial overview: Recent advances in metabolomics	24
Editorial overview: Glycobiology (2024)	24
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	24
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	23
Editorial Board	23

Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	23
Protein-based models offer mechanistic insight into complex nickel metalloenzymes	23
Editorial overview: Synthetic biomolecules for probing lipid membranes	23
Editorial Board	23
Lipidomics analysis in drug discovery and development	23
Analytical techniques in chemical biology	23
Editorial Board	23
Metalloprotein enabled redox signal transduction in microbes	23
Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141	22
Glutathione dynamics in subcellular compartments and implications for drug development	22
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	22
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	22
Sensing and regulation of reactive sulfur species (RSS) in bacteria	22
Catalyzing the future: recent advances in chemical synthesis using enzymes	22
Recent progress on small molecules targeting epigenetic complexes	21
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems	21
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	21
Discovery and evolution of [4 + 2] cyclases	21
Chemical synthesis and biological functions of carbohydrates	20
Targeting chemotherapy-resistant tumour sub-populations using inorganic chemistry: Anti-cancer stem cell metal complexes	20
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	20
The non-catalytic domains of O-GlcNAc cycling enzymes present new opportunities for function-specific control	20
Recent advances in high-throughput screening methods for small molecule modulators in bacteria	20
Recent strides in macromolecular targeted photodynamic therapy for cancer	20
Editorial: Mechanistic biology	20
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	20
Small-molecule tools for YEATS domain proteins	20
Strategies in engineering sustainable biochemical synthesis through microbial systems	20
Editorial Board	20
Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics	19
Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds	19
Show your true color: Mammalian cell surface staining for tracking cellular identity in multiplexing and beyond	19
Supramolecular platinum complexes for cancer therapy	19
Inhibition of p53 protein aggregation as a cancer treatment strategy	19
Realgar and arsenene nanomaterials as arsenic-based anticancer agents	19
Discovering functional small molecules in the gut microbiome	19
Chemical biology tools to probe bacterial glycans	19
Molecular probes for fluorescence image-guided cancer surgery	19
Reactions of lipid hydroperoxides and how they may contribute to ferroptosis sensitivity	19
Insights into SACS pathological attributes in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)☆	18
MicroRNA:Siglec crosstalk in cancer progression	18
New chemical processes to streamline carbohydrate synthesis	18
Editorial Board	18
Functions and mechanisms of enzymes assembling lignans and norlignans	18
Recent advances in de novo designed metallopeptides as tailored enzyme mimics	18
Microbial metabolite-receptor interactions in the gut microbiome	18
Sulfur-containing marine natural products as leads for drug discovery and development	18
Recent advances in data- and knowledge-driven approaches to explore primary microbial metabolism	18
Editorial Board	18
Recent advances in developing degraders & inhibitors of lysine methyltransferases	18
Strategies and mechanisms for endosomal escape of therapeutic nucleic acids	18
Recent progress in metal-based molecular probes for optical bioimaging and biosensing	17
Probing immune infiltration dynamics in cancer by in vivo imaging	17
Recent advances in the design and optimization of artificial metalloenzymes	17
Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles	17
Foldamer-mediated transport across phospholipid bilayers	17
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics	17
Recent advances on human milk oligosaccharide antimicrobial activity	16
Recent research progress in glycosylphosphatidylinositol-anchored protein biosynthesis, chemical/chemoenzymatic synthesis, and interaction with the cell membrane	16
Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging	16
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region	16
Deciphering combinatorial post-translational modifications by top-down mass spectrometry	16
Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity	16
Stimuli-responsive synthetic ionophores for therapeutic applications	16
Emerging fluorescence tools for the study of proteostasis in cells	16
Synthetic ion channels made of DNA	15
Natural and artificial siderophores: Iron-based applications and beyond	15
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides	15
Molecular-level interplay between intrinsically disordered clients and Hsp90	14
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer	14
Recent advances in the expanding genetic code	14
Recent advances in kinase signaling network profiling by mass spectrometry	14
Development of novel indicators and molecular systems for calcium sensing through protein engineering	14
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis	14
Emerging mechanisms of regulation for endoplasmic/sarcoplasmic reticulum Ca2+ stores by secretory pathway kinase FAM20C	14
Oxygen-transfer reactions by enzymatic flavin-N5 oxygen adducts—Oxidation is not a must	14
Recent advances in engineering microorganisms for the production of natural food colorants	14
Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism	14
Creating and understanding new-to-nature chemistry	14
Small molecules as modulators of phage–bacteria interactions	14

Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies	14
F420-dependent transformations in biosynthesis of secondary metabolites	13
Advances and challenges in programming pattern formation using living cells	13
Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling	13
New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance	13
Editorial Board	13
Quantitative interactome analysis with chemical cross-linking and mass spectrometry	13
Engineering novel adeno-associated viruses (AAVs) for improved delivery in the nervous system	13
The multifaceted repertoire of cellular reactive metabolites	12
Editorial overview - Exploring the diversity of polysaccharides	12
Chemical biology approaches to uncovering nuclear ROS control	12
Therapeutic synthetic anion transporters	12
Illuminating antifungal mode of action and resistance with fluorescent probes	12
How do metabolic processes age: Evidence from human metabolomic studies	12
Biosynthesis and recruitment of reactive amino acids in nonribosomal peptide assembly lines	12
KATs off: Biomedical insights from lysine acetyltransferase inhibitors	12
Evolving advances of proximity labeling in capturing biomolecular interactions	12
Microbial metabolism of host-derived antioxidants	12
Recent advances in mass spectrometry-based methods to investigate reversible cysteine oxidation	12
Expanding the viewpoint: Leveraging sequence information in enzymology	11
The emerging role of mass spectrometry-based proteomics in molecular pharming practices	11
Recent advances in Zn2+ imaging: From organelles to in vivo applications	11
Synthetic fragments of plant polysaccharides as tools for cell wall biology	11
Discovering microbiota functions via chemical probe incorporation for targeted sequencing	11
Substrate-selective small-molecule modulators of enzymes: Mechanisms and opportunities	11
Current strategies for characterization of mucin-domain glycoproteins	11
Highlights of bioinformatic tools and methods for validating bioinformatics derived hypotheses for microbial natural products research	11
Editorial Board	11
Inverse Drug Discovery identifies weak electrophiles affording protein conjugates	11
Genetically encoding latent bioreactive amino acids and the development of covalent protein drugs	11
Development of effective therapeutics for polysubstance use disorders	10
Electrophilic metabolites targeting the KEAP1/NRF2 partnership	10
Small-angle X-ray scattering studies of enzymes	10
Convergent and divergent biosynthetic strategies towards phosphonic acid natural products	10
Editorial Board	10
Editorial Board	10
Decoding the cellular effects of genetic variation through interaction proteomics	10
Editorial overview: Editorial of molecular imaging	10
How are hydrogen peroxide messages relayed to affect cell signalling?	10
An expanded molecular and systems toolbox for imaging, mapping, and controlling local translation	10
Towards sequence-based principles for protein phase separation predictions	10
Tuning specificity and topology of lectins through synthetic biology	10
Compounds for selective translational inhibition	10
A phenazine-inspired framework for identifying biological functions of microbial redox-active metabolites	10