Current Opinion in Chemical Biology

Article	Citations
Corrigendum to “Shedding light on complexity of protein–protein interactions in cancer” [Curr Opin Chem Biol 53 (2019) 75-81]	187
Small-molecule modulators of protein–RNA interactions	121
Fluorogenic polymethine dyes by intramolecular cyclization	107
Glycoengineering in antigen-specific immunotherapies	98
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	85
Engineered metallobiocatalysts for energy–relevant reactions	85
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	83
Imaging of proteases using activity-based probes	74
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	69
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	67
Synthetic transporters for oxoanions	66
Caged lipid probes for controlling lipid levels on subcellular scales	60
Site-specific bioconjugation and nuclear imaging	57
Extendable and explainable deep learning for pan-cancer radiogenomics research	55
New strategies for fluorescently labeling proteins in the study of amyloids	54
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	54
The Ramifications of synthetic biology	53
Recent advances in methods for quantifying the cell penetration of macromolecules	53
Characteristics of genetic tags for correlative light and electron microscopy	50
Activity-based protein profiling in microbes and the gut microbiome	49
Chemical inhibitors of transcription-associated kinases	48
Chemistry and biology of enzymes in protein glutathionylation	47
Past, present, and perspectives of protein N-terminal methylation	47
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	44
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	42

Critical considerations in N-glycoproteomics	42
Chemical probes for tagging mycobacterial lipids	42
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	41
Genetically encoded fluorescent sensors for metals in biology	38
Highlighting the roles of transition metals and speciation in chemical biology	37
Chemical engineering of bacterial effectors for regulating cell signaling and responses	36
Advances in the understanding and exploitation of carbohydrate-active enzymes	36
Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	36
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	36
Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF	35
Understanding and controlling amyloid aggregation with chirality	35
Editorial Board	35
Editorial Board	35
How nature incorporates sulfur and selenium into bioactive natural products	34
Natural and engineered precision antibiotics in the context of resistance	34
Super-multiplexed vibrational probes: Being colorful makes a difference	34
Chemical approaches for investigating site-specific protein S-fatty acylation	33
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	33
Emerging tools for bioluminescence imaging	33
Protein sequence design with deep generative models	33
Mechanism and inhibition of BRAF kinase	32
Induced proximity tools for precise manipulation of lipid signaling	31
A chemical field guide to histone nonenzymatic modifications	31
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	31
Recent advances in computational algorithms and software for large-scale glycoproteomics	30
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	30
Catalytic amyloids: Is misfolding folding?	30
Recent progress of TP/NIR fluorescent probes for metal ions	30
Targeting Son of Sevenless 1: The pacemaker of KRAS	29
Reducing the renal retention of low- to moderate-molecular-weight radiopharmaceuticals	29
Sulfoxides in medicine	29
Virus-assisted directed evolution of biomolecules	29
Chemoenzymatic strategies for RNA modification and labeling	28
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	28
Transferring enzyme features to molecular CO2 reduction catalysts	27
Emerging mammalian gene switches for controlling implantable cell therapies	27
Cysteine and methionine oxidation in thrombotic disorders	27
Recent advances in N- and C-terminus cysteine protein bioconjugation	27
New approaches to target RNA binding proteins	26
Targeted protein degradation: Emerging concepts and protein state-specific targeting principles	26
Emerging artificial metalloenzymes for asymmetric hydrogenation reactions	25
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	25
Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment	25
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	25
Molecular glues to stabilise protein–protein interactions	24
Bacterial peptidoglycan as a living polymer	24
SOD mimics: From the tool box of the chemists to cellular studies	24
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	24
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	23
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	23

Synthesis and application of bacterial exopolysaccharides	23
Synthetic peptide scaffolds as ion channels and molecular carriers	22
Exploring amyloid oligomers with peptide model systems	22
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	22
Inhibitors of DHHC family proteins	21
Promoting remyelination: A case study in regenerative medicine	21
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	21
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	21
Fluorescent indicators for imaging membrane potential of organelles	21
Peptides for disrupting and degrading amyloids	21
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	21
New frontiers in sulfur and selenium chemical biology	21
Advancements in chemical biology targeting the kinases and phosphatases of RNA polymerase II-mediated transcription	20
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	20
Engineering the bilayer: Emerging genetic tool kits for mechanistic lipid biology	20
Lipidomics analysis in drug discovery and development	20
Glutathione dynamics in subcellular compartments and implications for drug development	20
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	20
Protein-based models offer mechanistic insight into complex nickel metalloenzymes	19
Editorial Board	19
Editorial overview: Amyloid-inspired synthetic biomolecules	19
Analytical techniques in chemical biology	19
Editorial overview: Synthetic biomolecules for probing lipid membranes	19
Metalloprotein enabled redox signal transduction in microbes	19
Editorial Board	19
Editorial Board	19
Sensing and regulation of reactive sulfur species (RSS) in bacteria	18
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	18
Catalyzing the future: recent advances in chemical synthesis using enzymes	18
Editorial overview: Recent advances in metabolomics	18
Image-based cell phenotyping with deep learning	18
Editorial Board	18
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment	18
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	18
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	18
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	18
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	17
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	17
Editorial: Mechanistic biology	17
Recent advances in the mass spectrometric profiling of bacterial lipids	17
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	17
Discovery and evolution of [4 + 2] cyclases	17
Strategies in engineering sustainable biochemical synthesis through microbial systems	16
Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo	16
Molecular probes for fluorescence image-guided cancer surgery	16
Recent advances in high-throughput screening methods for small molecule modulators in bacteria	16
Recent progress on small molecules targeting epigenetic complexes	16
Discovering functional small molecules in the gut microbiome	16
The non-catalytic domains of O-GlcNAc cycling enzymes present new opportunities for function-specific control	16
Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds	16
Structures of chromatin modulators in complex with nucleosome	16
Small-molecule tools for YEATS domain proteins	16
Chemical biology tools to probe bacterial glycans	16
Recent strides in macromolecular targeted photodynamic therapy for cancer	16
Supramolecular platinum complexes for cancer therapy	15
Targeting chemotherapy-resistant tumour sub-populations using inorganic chemistry: Anti-cancer stem cell metal complexes	15
Insights into SACS pathological attributes in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)☆	15
Emerging chelators for nuclear imaging	15
Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics	15
Inhibition of p53 protein aggregation as a cancer treatment strategy	15
Adapting protein sequences for optimized therapeutic efficacy	15
Reactions of lipid hydroperoxides and how they may contribute to ferroptosis sensitivity	15
Corrigendum to “Interaction profiling methods to map protein and pathway targets of bioactive ligands”, [Curr Opin Chem Biol 54 (February 2020) 76–84]	15
Realgar and arsenene nanomaterials as arsenic-based anticancer agents	15
Editorial Board	14
Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles	14
Metabolite assemblies: A surprising extension to the amyloid hypothesis	14
Intrinsically disordered proteins and biomolecular condensates as drug targets	14
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics	14
Recent advances in data- and knowledge-driven approaches to explore primary microbial metabolism	14
Targeting of extracellular protein–protein interactions with macrocyclic peptides	14
Functions and mechanisms of enzymes assembling lignans and norlignans	14
Editorial Board	14
Systems for in vivo hypermutation: a quest for scale and depth in directed evolution	14
Show your true color: Mammalian cell surface staining for tracking cellular identity in multiplexing and beyond	14
Imaging-guided nanomedicine development	14
Probing immune infiltration dynamics in cancer by in vivo imaging	13
MicroRNA:Siglec crosstalk in cancer progression	13
Recent progress in metal-based molecular probes for optical bioimaging and biosensing	13
Microbial metabolite-receptor interactions in the gut microbiome	13

Recent advances in developing degraders & inhibitors of lysine methyltransferases	13
Recent advances in the design and optimization of artificial metalloenzymes	13
Sulfur-containing marine natural products as leads for drug discovery and development	13
In silico, in vitro, and in vivo machine learning in synthetic biology and metabolic engineering	13
New chemical processes to streamline carbohydrate synthesis	13
Strategies and mechanisms for endosomal escape of therapeutic nucleic acids	13
Stimuli-responsive synthetic ionophores for therapeutic applications	12
Synthetic ion channels made of DNA	12
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region	12
Foldamer-mediated transport across phospholipid bilayers	12
Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging	12
Recent research progress in glycosylphosphatidylinositol-anchored protein biosynthesis, chemical/chemoenzymatic synthesis, and interaction with the cell membrane	12
Maximizing content across scales: Moving multimodal microscopy and mesoscopy toward molecular imaging	12
Molecular-level interplay between intrinsically disordered clients and Hsp90	11
Development of novel indicators and molecular systems for calcium sensing through protein engineering	11
Deciphering combinatorial post-translational modifications by top-down mass spectrometry	11
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides	11
Emerging mechanisms of regulation for endoplasmic/sarcoplasmic reticulum Ca2+ stores by secretory pathway kinase FAM20C	11
Recent advances in the expanding genetic code	11
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis	11
Recent advances on human milk oligosaccharide antimicrobial activity	11
Cytokine engineering for targeted cancer immunotherapy	11
Oxygen-transfer reactions by enzymatic flavin-N5 oxygen adducts—Oxidation is not a must	11
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer	11
Emerging fluorescence tools for the study of proteostasis in cells	11
Small molecules as modulators of phage–bacteria interactions	10
Recent advances in kinase signaling network profiling by mass spectrometry	10
Advances and challenges in programming pattern formation using living cells	10
F420-dependent transformations in biosynthesis of secondary metabolites	10
Editorial overview: Hot targets and new modalities	10
Recent advances in engineering microorganisms for the production of natural food colorants	10
Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling	10
Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies	10
Recent developments in ligands and chemical probes targeting solute carrier transporters	10
Quantitative interactome analysis with chemical cross-linking and mass spectrometry	10
Engineering novel adeno-associated viruses (AAVs) for improved delivery in the nervous system	10
Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism	10
Editorial Board	10
New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance	10
Microbial metabolism of host-derived antioxidants	10
How do metabolic processes age: Evidence from human metabolomic studies	9
Therapeutic synthetic anion transporters	9
Biosynthesis and recruitment of reactive amino acids in nonribosomal peptide assembly lines	9
Recent advances in Zn2+ imaging: From organelles to in vivo applications	9
Highlights of bioinformatic tools and methods for validating bioinformatics derived hypotheses for microbial natural products research	9
Synthetic fragments of plant polysaccharides as tools for cell wall biology	9
Editorial overview - Exploring the diversity of polysaccharides	9
Chemical biology approaches to uncovering nuclear ROS control	9
Substrate-selective small-molecule modulators of enzymes: Mechanisms and opportunities	9
Discovering microbiota functions via chemical probe incorporation for targeted sequencing	9
The emerging role of mass spectrometry-based proteomics in molecular pharming practices	9
Recent advances in mass spectrometry-based methods to investigate reversible cysteine oxidation	9
Illuminating antifungal mode of action and resistance with fluorescent probes	9
KATs off: Biomedical insights from lysine acetyltransferase inhibitors	9
A phenazine-inspired framework for identifying biological functions of microbial redox-active metabolites	9
Machine learning for profile prediction in genomics	9
Inverse Drug Discovery identifies weak electrophiles affording protein conjugates	9
Current strategies for characterization of mucin-domain glycoproteins	8
Direct visualization and profiling of protein misfolding and aggregation in live cells	8
Decoding the cellular effects of genetic variation through interaction proteomics	8
Small-angle X-ray scattering studies of enzymes	8
Towards sequence-based principles for protein phase separation predictions	8
Programmable tools for targeted analysis of epigenetic DNA modifications	8
Expanding the viewpoint: Leveraging sequence information in enzymology	8
Editorial Board	8
An expanded molecular and systems toolbox for imaging, mapping, and controlling local translation	8
Tuning specificity and topology of lectins through synthetic biology	8
Genetically encoding latent bioreactive amino acids and the development of covalent protein drugs	8
Electrophilic metabolites targeting the KEAP1/NRF2 partnership	8
Recent advances in drug repurposing using machine learning	8
Development of effective therapeutics for polysubstance use disorders	8
How are hydrogen peroxide messages relayed to affect cell signalling?	8