Current Opinion in Chemical Biology

Article	Citations
Machine learning in protein structure prediction	168
Single-cell protein analysis by mass spectrometry	122
Protein sequence design with deep generative models	104
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment	93
Recent developments in bioorthogonal chemistry and the orthogonality within	92
Transition metal catalysts for the bioorthogonal synthesis of bioactive agents	84
Activity- and reactivity-based proteomics: Recent technological advances and applications in drug discovery	79
Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics	78
Metabolic engineering strategies toward production of biofuels	74
Intrinsically disordered proteins and biomolecular condensates as drug targets	71
Image-based cell phenotyping with deep learning	70
The blind men and the filament: Understanding structures and functions of microbial nanowires	67
Structure-based protein design with deep learning	67
Targeting Son of Sevenless 1: The pacemaker of KRAS	60
BET bromodomain inhibitors	58
Siglec and anti-Siglec therapies	57
Protein metalation in biology	54
Anatomy of a crosslinker	53
Emerging tools for bioluminescence imaging	51
Chemiluminescent spiroadamantane-1,2-dioxetanes: Recent advances in molecular imaging and biomarker detection	49
The rise of covalent proteolysis targeting chimeras	48
Directed evolution for enzyme development in biocatalysis	48
SOD mimics: From the tool box of the chemists to cellular studies	47
Natural product discovery through microbial genome mining	46
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	46

Recent progress on the prospective application of machine learning to structure-based virtual screening	45
New approaches to target RNA binding proteins	45
New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance	44
Recent progress in synthesis of carbohydrates with sugar nucleotide-dependent glycosyltransferases	44
Cytokine engineering for targeted cancer immunotherapy	43
Shewanella biofilm development and engineering for environmental and bioenergy applications	43
Current state on the enzymatic synthesis of glycosaminoglycans	41
Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment	41
Enzyme evolution in natural products biosynthesis: target- or diversity-oriented?	40
Recent advances in mass spectrometry–based peptidomics workflows to identify short-open-reading-frame-encoded peptides and explore their functions	40
Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes	39
Supramolecular metal-based nanoparticles for drug delivery and cancer therapy	39
Molecular mechanisms of microbial transmembrane electron transfer of electrochemically active bacteria	39
Recent progress in metal-based molecular probes for optical bioimaging and biosensing	38
Chemical warfare between fungus-growing ants and their pathogens	37
Recent advances in drug repurposing using machine learning	36
Potential-dependent extracellular electron transfer pathways of exoelectrogens	35
Recent advance in the biosynthesis of nitrogen–nitrogen bond–containing natural products	35
Toward synthetic life: Biomimetic synthetic cell communication	35
Expanding the applicability of cytochrome P450s and other haemoproteins	34
Engineering Clostridium ljungdahlii as the gas-fermenting cell factory for the production of biofuels and biochemicals	34
Advanced functional fluorescent probes for cell plasma membranes	34
Generating orthogonal glycosyltransferase and nucleotide sugar pairs as next-generation glycobiology tools	34
The evolving capabilities of enzyme-mediated proximity labeling	34
Connecting chemistry and biology through molecular descriptors	34
Mass spectrometry techniques for imaging and detection of metallodrugs	33
Inhibitors of DHHC family proteins	32
Systems for in vivo hypermutation: a quest for scale and depth in directed evolution	32
Molecular simulations of complex carbohydrates and glycoconjugates	31
Emerging chelators for nuclear imaging	31
Supramolecular coordination complexes as diagnostic and therapeutic agents	31
Rewiring yeast metabolism to synthesize products beyond ethanol	31
Not so innocent: Impact of fluorophore chemistry on the in vivo properties of bioconjugates	30
Biogenesis of the peptide-derived redox cofactor pyrroloquinoline quinone	30
Synthetic biomolecular condensates to engineer eukaryotic cells	30
Current strategies for characterization of mucin-domain glycoproteins	30
Caged lipids for subcellular manipulation	30
Chemical biology of protein citrullination by the protein A arginine deiminases	30
Metal complexes as optical probes for DNA sensing and imaging	28
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	28
Quantitative interactome analysis with chemical cross-linking and mass spectrometry	28
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	27
Reducing the renal retention of low- to moderate-molecular-weight radiopharmaceuticals	27
Metallo-β-lactamases and a tug-of-war for the available zinc at the host–pathogen interface	27
All-atom simulations to studying metallodrugs/target interactions	26
Deciphering combinatorial post-translational modifications by top-down mass spectrometry	26
Spatial metabolomics principles and application to cancer research	26
Critical considerations in N-glycoproteomics	26
Chemical synthesis of polysaccharides	25
Non-conventional hosts for the production of fuels and chemicals	25

Molecular probes for fluorescence image-guided cancer surgery	25
Exploring amyloid oligomers with peptide model systems	25
Characterising biomolecular interactions and dynamics with mass photometry	24
Recent advances in mass spectrometry-based computational metabolomics	24
Imaging organelle membranes in live cells at the nanoscale with lipid-based fluorescent probes	24
Biosynthesis of marine toxins	24
Substrates and interactors of the ClpP protease in the mitochondria	23
Photoaffinity labeling approaches to elucidate lipid–protein interactions	23
New strategies for fluorescently labeling proteins in the study of amyloids	23
Catalytic amyloids: Is misfolding folding?	23
Emerging frontiers in virtual drug discovery: From quantum mechanical methods to deep learning approaches	23
Genetically encoding latent bioreactive amino acids and the development of covalent protein drugs	22
Natural and engineered transglycosylases: Green tools for the enzyme-based synthesis of glycoproducts	22
Beyond mere DNA damage: Recent progress in platinum(IV) anticancer complexes containing multi-functional axial ligands	22
Versatile signaling mechanisms of inositol pyrophosphates	22
Tailoring microbes to upgrade lignin	22
In silico, in vitro, and in vivo machine learning in synthetic biology and metabolic engineering	22
From structure to application: Progress and opportunities in peptide materials development	21
Current processes and future challenges of photoautotrophic production of acetyl-CoA-derived solar fuels and chemicals in cyanobacteria	21
Bromodomain inhibitors and therapeutic applications	21
Highlighting the roles of transition metals and speciation in chemical biology	20
Molecular glues to stabilise protein–protein interactions	20
Chemogenetic and optogenetic control of post-translational modifications through genetic code expansion	20
New strategies to identify protease substrates	20
Understanding and controlling amyloid aggregation with chirality	20
Recent advances in polysaccharide-based in situ forming hydrogels	20
Phospholipid-coated targeted microbubbles for ultrasound molecular imaging and therapy	19
Past, present, and perspectives of protein N-terminal methylation	19
Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo	19
Emerging roles of O-glycosylation in regulating protein aggregation, phase separation, and functions	19
Sulfoxides in medicine	19
A critical evaluation of probes for cysteine sulfenic acid	18
Promising heterometallic compounds as anticancer agents: Recent studies in vivo	18
Mechanosensitive channels of Corynebacterium glutamicum functioning as exporters of l-glutamate and other valuable metabolites	18
Metal-based environment-sensitive MRI contrast agents	18
Peptides for disrupting and degrading amyloids	18
Mitochondria as a target of third row transition metal-based anticancer complexes	18
Chemical regulation of the cGAS-STING pathway	18
Emerging role of ferrous iron in bacterial growth and host–pathogen interaction: New tools for chemical (micro)biology and antibacterial therapy	17
Methods to identify protein targets of metal-based drugs	17
Small-angle X-ray scattering studies of enzymes	17
Mapping messenger RNA methylations at single base resolution	17
Stereo-electronic control of reaction selectivity in short-chain dehydrogenases: Decarboxylation, epimerization, and dehydration	17
Application of X-ray absorption and X-ray fluorescence techniques to the study of metallodrug action	17
Inhibition of p53 protein aggregation as a cancer treatment strategy	17
Deuterium Raman imaging for lipid analysis	17
Designed protease-based signaling networks	16
Metabolite assemblies: A surprising extension to the amyloid hypothesis	16
Recent advances in computational algorithms and software for large-scale glycoproteomics	16
Extendable and explainable deep learning for pan-cancer radiogenomics research	16
The catalytic mechanism of sulfoxide synthases	16
Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds	16
KATs off: Biomedical insights from lysine acetyltransferase inhibitors	16
Recent advances in functional analysis of polyunsaturated fatty acid synthases	15
Recent developments in ligands and chemical probes targeting solute carrier transporters	15
Molecular evolution and functional divergence of UDP-hexose 4-epimerases	15
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region	15
Emerging chemistry and biology in protein glutathionylation	15
Metallomics and other omics approaches in antiparasitic metal-based drug research	15
Chemical probes for tagging mycobacterial lipids	15
Recent advances in induced proximity modalities	15
Engineered living materials (ELMs) design: From function allocation to dynamic behavior modulation	15
Targeting mutant KRAS	15
Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	15
Recent advances on human milk oligosaccharide antimicrobial activity	15
Drugging the undruggable proteins in cancer: A systems biology approach	15
Imaging-guided nanomedicine development	14
Advances in membrane mimetics and mass spectrometry for understanding membrane structure and function	14
Improved methods for targeting epigenetic reader domains of acetylated and methylated lysine	14
Recent progress of TP/NIR fluorescent probes for metal ions	14
Rejuvenating old fluorophores with new chemistry	14
Recent advances in intravital microscopy for preclinical research	14
Engineering Rieske oxygenase activity one piece at a time	14
The ubiquitin proteoform problem	14
Shedding light on current trends in molecular optogenetics	14
Thermal proteome profiling: Insights into protein modifications, associations, and functions	13
The chemical biology of NAD+ regulation in axon degeneration	13
Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF	13
Consequences of post-translational modifications on amyloid proteins as revealed by protein semisynthesis	13
Towards sequence-based principles for protein phase separation predictions	13

Chemistry and biology of enzymes in protein glutathionylation	13
Bioaldehydes and beyond: Expanding the realm of bioderived chemicals using biogenic aldehydes as platforms	13
Chemoenzymatic strategies for RNA modification and labeling	13
Taming glutathione potentiates metallodrug action	12
Targeting chemotherapy-resistant tumour sub-populations using inorganic chemistry: Anti-cancer stem cell metal complexes	12
Sulfur-containing marine natural products as leads for drug discovery and development	12
Machine learning for profile prediction in genomics	12
Targeting of extracellular protein–protein interactions with macrocyclic peptides	12
Lipidomics analysis in drug discovery and development	12
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	12
Dissecting the copper bioinorganic chemistry of the functional and pathological roles of the prion protein: Relevance in Alzheimer's disease and cancer	12
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	12
Chemical and optical control of CRISPR-associated nucleases	12
Induced proximity tools for precise manipulation of lipid signaling	11
Recent advances in kinase signaling network profiling by mass spectrometry	11
Probing immune infiltration dynamics in cancer by in vivo imaging	11
The multifaceted nature of peroxiredoxins in chemical biology	11
Multi-omics approaches to study platelet mechanisms	11
Chemical inhibitors of transcription-associated kinases	11
Hyperpolarized NMR metabolomics	11
Supramolecular glycopolymers: How carbohydrates matter in structure, dynamics, and function	11
New advances in cross-linking mass spectrometry toward structural systems biology	11
Sulfur-containing peptides: Synthesis and application in the discovery of potential drug candidates	11
Emerging mammalian gene switches for controlling implantable cell therapies	11
Realgar and arsenene nanomaterials as arsenic-based anticancer agents	10
Toward molecular imaging using spectral photon-counting computed tomography?	10
A chemical field guide to histone nonenzymatic modifications	10
Mechanism and inhibition of BRAF kinase	10
Recent progress on small molecules targeting epigenetic complexes	10
Current mechanistic understanding of intermembrane lipid trafficking important for maintenance of bacterial outer membrane lipid asymmetry	10
Inverse Drug Discovery identifies weak electrophiles affording protein conjugates	10
Platinum glycoconjugates: “Sweet bullets” for targeted cancer therapy?	10
Super-multiplexed vibrational probes: Being colorful makes a difference	10
Protein engineering for selective proteomics	10
Deconvoluting the biology and druggability of protein lipidation using chemical proteomics	10
Chemical tools targeting readers of lysine methylation	10
Crystallography of polysaccharides: Current state and challenges	10
Platinum-based combination nanomedicines for cancer therapy	10
Spatial single cell metabolomics: Current challenges and future developments	10
Distinct biochemical properties of the class I histone deacetylase complexes	10
Computational modeling of carbohydrate processing enzymes reactions	10
Recent development of polysulfides: Chemistry and biological applications	9
Residue selective crosslinking of proteins through photoactivatable or proximity-enabled reactivity	9
Coupling chemical biology and vibrational spectroscopy for studies of amyloids in vitro and in cells	9
Post-translational modifications of histone proteins by monoamine neurotransmitters	9
Electrogenetics: Bridging synthetic biology and electronics to remotely control the behavior of mammalian designer cells	9
Recent advances in dissecting the demethylation reactions in natural product biosynthesis	9
Toward enhanced performance of integrated photo-bioelectrochemical systems: Taxa and functions in bacteria–algae communities	9
Molecular network strategy in multi-omics and mass spectrometry imaging	9
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	9
Direct visualization and profiling of protein misfolding and aggregation in live cells	9
The chemical basis of cytotoxicity of silicon-phthalocyanine-based near infrared photoimmunotherapy (NIR-PIT) and its implications for treatment monitoring	8
Recent chemical synthesis of plant polysaccharides	8
Metabolomic profiling reveals bacterial metabolic adaptation strategies and new metabolites	8
Synthetic fragments of plant polysaccharides as tools for cell wall biology	8
Advances and challenges in programming pattern formation using living cells	8
Study of spatiotemporal regulation of kinase signaling using genetically encodable molecular tools	8
Compounds for selective translational inhibition	8
Role of conformational dynamics in pathogenic protein aggregation	8
Recent chemical synthesis and immunological evaluation of glycans related to bacterial lipopolysaccharides	8
Visualizing the complexity of proteins in living cells with genetic code expansion	8
Targeted protein degradation: Emerging concepts and protein state-specific targeting principles	8
Recent progress in dissecting ubiquitin signals with chemical biology tools	8
Engineering the human gut commensal Bacteroides thetaiotaomicron with synthetic biology	8
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	8
Maximizing content across scales: Moving multimodal microscopy and mesoscopy toward molecular imaging	8
Insights into SACS pathological attributes in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)☆	8
Challenges in studying the liquid-to-solid phase transitions of proteins using computer simulations	8
Recent advances in N- and C-terminus cysteine protein bioconjugation	8
Structures of chromatin modulators in complex with nucleosome	8
Genetically encoded fluorescent sensors for metals in biology	8
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	8
Fluorescent indicators for imaging membrane potential of organelles	8
Improving precision surgery: A review of current intraoperative nerve tissue fluorescence imaging	7
The bright frontiers of microbial metabolic optogenetics	7
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level	7
Substrate-selective small-molecule modulators of enzymes: Mechanisms and opportunities	7
Supramolecular platinum complexes for cancer therapy	7
Chemical approaches for investigating site-specific protein S-fatty acylation	7
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	7
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	7
Show your true color: Mammalian cell surface staining for tracking cellular identity in multiplexing and beyond	7
Carbohydrate de-N-acetylases acting on structural polysaccharides and glycoconjugates	7
Virus-assisted directed evolution of biomolecules	7
How nature incorporates sulfur and selenium into bioactive natural products	7
Caged lipid probes for controlling lipid levels on subcellular scales	7
NMR spectroscopy to study the fate of metallodrugs in cells	7
Epigenomic links from metabolism—methionine and chromatin architecture	7
Recent advances towards mass spectrometry-based clinical lipidomics	7