Current Opinion in Chemical Biology

Article	Citations
Fluorogenic polymethine dyes by intramolecular cyclization	177
Small-molecule modulators of protein–RNA interactions	82
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes	81
Engineered metallobiocatalysts for energy–relevant reactions	71
Imaging of proteases using activity-based probes	71
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones	68
Glycoengineering in antigen-specific immunotherapies	68
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis	61
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes	60
Activity-based protein profiling in microbes and the gut microbiome	58
Editorial Board	57
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome	54
The Ramifications of synthetic biology	53
Characteristics of genetic tags for correlative light and electron microscopy	53
Recent advances in methods for quantifying the cell penetration of macromolecules	52
Chemical inhibitors of transcription-associated kinases	51
Site-specific bioconjugation and nuclear imaging	50
Synthetic transporters for oxoanions	50
Caged lipid probes for controlling lipid levels on subcellular scales	45
Always on the move: Mapping spatiotemporal interactome with proximity labeling in mammalian cells	44
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes	44
Covalent lysine targeting is coming of age	44
Toward universal binder discovery: Advances in display, computational design and in vivo platforms	43
Chemistry and biology of enzymes in protein glutathionylation	43
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications	43

Highlighting the roles of transition metals and speciation in chemical biology	42
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	42
DVD-IgG1 antibody–drug conjugates: Expanding the landscape of targeted cancer therapy	42
Critical considerations in N-glycoproteomics	40
Editorial Board	40
Advances in the understanding and exploitation of carbohydrate-active enzymes	40
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations	39
From the forest floor to the lab: Insights into the diversity and complexity of mushroom polyketide synthases	39
Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications	38
Editorial Board	37
Editorial Board	37
Genetically encoded fluorescent sensors for metals in biology	37
Towards chemoenzymatic labeling strategies for profiling protein glycosylation	36
How nature incorporates sulfur and selenium into bioactive natural products	35
Natural and engineered precision antibiotics in the context of resistance	35
Virus-assisted directed evolution of biomolecules	34
Editorial: Unusual enzyme reactions in natural products biosynthesis	34
Sulfoxides in medicine	34
Mechanism and inhibition of BRAF kinase	34
Recent advances in computational algorithms and software for large-scale glycoproteomics	34
Recent progress of TP/NIR fluorescent probes for metal ions	33
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death	32
Recent advances in protein modification–enabled potential therapeutics	32
Transferring enzyme features to molecular CO2 reduction catalysts	32
Cysteine and methionine oxidation in thrombotic disorders	32
In vivo-compatible proximity labeling technologies	32
Recent advances in N- and C-terminus cysteine protein bioconjugation	31
Recent advances in enzyme cascade reactions for the efficient synthesis of functionalized chemicals and complex pharmaceuticals	31
Structural insights into the half-of-sites reactivity in homodimeric and homotetrameric metalloenzymes	31
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes	30
Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging	30
Synthetic peptide scaffolds as ion channels and molecular carriers	30
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm	29
Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities	29
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops	29
Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization	29
Promoting remyelination: A case study in regenerative medicine	28
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells	28
Synthesis and application of bacterial exopolysaccharides	28
New frontiers in sulfur and selenium chemical biology	28
Bacterial peptidoglycan as a living polymer	28
Fluorescent indicators for imaging membrane potential of organelles	28
Molecular glues to stabilise protein–protein interactions	28
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis	27
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport	27
Editorial Board	27
Next-generation interleukin-enhanced immunotherapies: From molecular engineering to armored T-cell architectures	27
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic	27
The evolving logic of biocatalyzed nucleic acid synthesis	27
Editorial Board	26

Editorial Board	26
Editorial overview: Synthetic biomolecules for probing lipid membranes	26
Metalloprotein enabled redox signal transduction in microbes	25
Editorial overview: Recent advances in metabolomics	25
Editorial overview: Glycobiology (2024)	25
Editorial Board	25
Sensing and regulation of reactive sulfur species (RSS) in bacteria	25
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo	25
Analytical techniques in chemical biology	24
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems	24
Glutathione dynamics in subcellular compartments and implications for drug development	24
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions	24
Lipidomics analysis in drug discovery and development	24
Recent advances in mapping protein networks regulated by post-translational modifications via proximity tagging	24
Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting	24
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases	24
Probing metalloenzyme dynamics in living systems: Contemporary advances in fluorescence imaging tools and applications	24
Catalyzing the future: recent advances in chemical synthesis using enzymes	24
Chemical probes for investigating protein liquid-liquid phase separation and aggregation	23
Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141	23
Editorial: Mechanistic biology	22
Chemical synthesis and biological functions of carbohydrates	22
Editorial Board	22
Discovery and evolution of [4 + 2] cyclases	22
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks	22
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	22
Recent advances in high-throughput screening methods for small molecule modulators in bacteria	21
Supramolecular platinum complexes for cancer therapy	21
The non-catalytic domains of O-GlcNAc cycling enzymes present new opportunities for function-specific control	21
Targeting chemotherapy-resistant tumour sub-populations using inorganic chemistry: Anti-cancer stem cell metal complexes	21
Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds	21
Chemical biology tools to probe bacterial glycans	21
Discovering functional small molecules in the gut microbiome	21
Strategies in engineering sustainable biochemical synthesis through microbial systems	21
Recent strides in macromolecular targeted photodynamic therapy for cancer	20
Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics	20
Inhibition of p53 protein aggregation as a cancer treatment strategy	20
Small-molecule tools for YEATS domain proteins	20
Functions and mechanisms of enzymes assembling lignans and norlignans	20
Reactions of lipid hydroperoxides and how they may contribute to ferroptosis sensitivity	20
Realgar and arsenene nanomaterials as arsenic-based anticancer agents	20
Recent advances in the design and optimization of artificial metalloenzymes	19
Editorial Board	19
MicroRNA:Siglec crosstalk in cancer progression	19
Insights into SACS pathological attributes in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)☆	19
Editorial Board	19
Recent advances in developing degraders & inhibitors of lysine methyltransferases	19
Recent advances in data- and knowledge-driven approaches to explore primary microbial metabolism	19
Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles	18
Microbial metabolite-receptor interactions in the gut microbiome	18
Strategies and mechanisms for endosomal escape of therapeutic nucleic acids	18
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics	18
Recent development of fluorescent probes for hydrogen per/polysulfides	18
Recent advances in de novo designed metallopeptides as tailored enzyme mimics	18
Sulfur-containing marine natural products as leads for drug discovery and development	18
New chemical processes to streamline carbohydrate synthesis	18
Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity	18
Natural and artificial siderophores: Iron-based applications and beyond	17
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region	17
Synthetic ion channels made of DNA	17
Nucleic acid catalysts: From the origin of life to modern applications	17
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides	17
Stimuli-responsive synthetic ionophores for therapeutic applications	17
Recent research progress in glycosylphosphatidylinositol-anchored protein biosynthesis, chemical/chemoenzymatic synthesis, and interaction with the cell membrane	17
Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging	17
Recent advances on human milk oligosaccharide antimicrobial activity	17
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis	17
Foldamer-mediated transport across phospholipid bilayers	17
Deciphering combinatorial post-translational modifications by top-down mass spectrometry	17
Emerging mechanisms of regulation for endoplasmic/sarcoplasmic reticulum Ca2+ stores by secretory pathway kinase FAM20C	16
Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism	16
Recent advances in engineering microorganisms for the production of natural food colorants	16
Creating and understanding new-to-nature chemistry	16
Oxygen-transfer reactions by enzymatic flavin-N5 oxygen adducts—Oxidation is not a must	16
Molecular-level interplay between intrinsically disordered clients and Hsp90	16
Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies	16
Recent advances in kinase signaling network profiling by mass spectrometry	15
Development of novel indicators and molecular systems for calcium sensing through protein engineering	15
Recent advances in the expanding genetic code	15
Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling	15

Editorial Board	15
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer	15
F420-dependent transformations in biosynthesis of secondary metabolites	14
Advances and challenges in programming pattern formation using living cells	14
Illuminating antifungal mode of action and resistance with fluorescent probes	14
Small molecules as modulators of phage–bacteria interactions	14
KATs off: Biomedical insights from lysine acetyltransferase inhibitors	14
Biosynthesis and recruitment of reactive amino acids in nonribosomal peptide assembly lines	14
The multifaceted repertoire of cellular reactive metabolites	14
Engineering novel adeno-associated viruses (AAVs) for improved delivery in the nervous system	14
Editorial overview - Exploring the diversity of polysaccharides	14
Synthetic fragments of plant polysaccharides as tools for cell wall biology	14
How do metabolic processes age: Evidence from human metabolomic studies	13
Editorial Board	13
Substrate-selective small-molecule modulators of enzymes: Mechanisms and opportunities	13
Therapeutic synthetic anion transporters	13
Recent advances in mass spectrometry-based methods to investigate reversible cysteine oxidation	13
Expanding the viewpoint: Leveraging sequence information in enzymology	13
Microbial metabolism of host-derived antioxidants	13
Chemical biology approaches to uncovering nuclear ROS control	13
The emerging role of mass spectrometry-based proteomics in molecular pharming practices	13
Evolving advances of proximity labeling in capturing biomolecular interactions	13
Highlights of bioinformatic tools and methods for validating bioinformatics derived hypotheses for microbial natural products research	12
Recent advances beyond classical bioorthogonal chemistry	12
Discovering microbiota functions via chemical probe incorporation for targeted sequencing	12
Current strategies for characterization of mucin-domain glycoproteins	12
Chemical and synthetic biology tools to interrogate and control cell–cell interactions in vivo	12
Recent advances in Zn2+ imaging: From organelles to in vivo applications	12
A phenazine-inspired framework for identifying biological functions of microbial redox-active metabolites	12
How are hydrogen peroxide messages relayed to affect cell signalling?	11
Electrophilic metabolites targeting the KEAP1/NRF2 partnership	11
Editorial Board	11
Tuning specificity and topology of lectins through synthetic biology	11
An expanded molecular and systems toolbox for imaging, mapping, and controlling local translation	11
Small-angle X-ray scattering studies of enzymes	11
Editorial Board	11
Towards sequence-based principles for protein phase separation predictions	10
Editorial overview: Glycobiology (2023)	10
Bacterial glycoengineering: Cell-based and cell-free routes for producing biopharmaceuticals with customized glycosylation	10
Compounds for selective translational inhibition	10
Editorial overview: Editorial of molecular imaging	10
Editorial Board	10
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level	10