Current Opinion in Chemical Biology

Article	Citations
Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?	220
Machine learning in protein structure prediction	136
Single-cell protein analysis by mass spectrometry	105
Biocatalysis in drug discovery and development	103
Protein immobilization technology for flow biocatalysis	96
Recent advances of thiol-selective bioconjugation reactions	93
Protein sequence design with deep generative models	85
Emerging strategies for expanding the toolbox of enzymes in biocatalysis	85
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment	79
Recent developments in bioorthogonal chemistry and the orthogonality within	77
Targeted protein degradation: current and future challenges	73
Bacterial enzymes for lignin depolymerisation: new biocatalysts for generation of renewable chemicals from biomass	72
Activity- and reactivity-based proteomics: Recent technological advances and applications in drug discovery	70
Transition metal catalysts for the bioorthogonal synthesis of bioactive agents	69
Recent achievements and current trajectories of diversity-oriented synthesis	68
Recent progress in the development of organometallics for the treatment of cancer	65
Pictet–Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis	65
Integrating biocatalysis with chemocatalysis for selective transformations	62
The blind men and the filament: Understanding structures and functions of microbial nanowires	61
Intrinsically disordered proteins and biomolecular condensates as drug targets	58
Metabolic engineering strategies toward production of biofuels	58
Image-based cell phenotyping with deep learning	55
Advances of epigenetic editing	53
How synthetic biology can help bioremediation	52
Targeting Son of Sevenless 1: The pacemaker of KRAS	52

Structure-based protein design with deep learning	51
Inhibitors of the mitochondrial calcium uniporter for the treatment of disease	49
Mammalian iron–sulfur cluster biogenesis: Recent insights into the roles of frataxin, acyl carrier protein and ATPase-mediated transfer to recipient proteins	48
Anatomy of a crosslinker	47
Siglec and anti-Siglec therapies	47
Recent advances in the chemoenzymatic synthesis of bioactive natural products	46
The rise of covalent proteolysis targeting chimeras	45
Proteolysis targeting chimeras (PROTACs) for epigenetics research	45
Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery	43
Metalloproteomics in conjunction with other omics for uncovering the mechanism of action of metallodrugs: Mechanism-driven new therapy development	43
Emerging tools for bioluminescence imaging	43
Exploiting azide–alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes	42
Gold compounds for catalysis and metal-mediated transformations in biological systems	41
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	40
Drugging histone methyltransferases in cancer	39
BET bromodomain inhibitors	39
Protein metalation in biology	39
Shewanella biofilm development and engineering for environmental and bioenergy applications	39
Natural product discovery through microbial genome mining	39
Domain-selective targeting of BET proteins in cancer and immunological diseases	39
Directed evolution for enzyme development in biocatalysis	38
Recent progress in synthesis of carbohydrates with sugar nucleotide-dependent glycosyltransferases	38
New approaches to target RNA binding proteins	38
Supramolecular metal-based nanoparticles for drug delivery and cancer therapy	38
Iron–sulfur cluster signaling: The common thread in fungal iron regulation	38
Enzymes with noncanonical amino acids	38
Towards a more precise therapy in cancer: Exploring epigenetic complexity	38
Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics	37
Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment	37
New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance	36
Harnessing and engineering amide bond forming ligases for the synthesis of amides	36
Recent advances in mass spectrometry–based peptidomics workflows to identify short-open-reading-frame-encoded peptides and explore their functions	36
Recent progress on the prospective application of machine learning to structure-based virtual screening	36
Cytokine engineering for targeted cancer immunotherapy	35
Fluorine biocatalysis	34
Targeting histone acetylation/deacetylation in parasites: an update (2017–2020)	34
Bacterial manganese sensing and homeostasis	34
Generating orthogonal glycosyltransferase and nucleotide sugar pairs as next-generation glycobiology tools	33
Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes	33
The evolving capabilities of enzyme-mediated proximity labeling	33
Isocitrate dehydrogenase variants in cancer — Cellular consequences and therapeutic opportunities	33
Chemical warfare between fungus-growing ants and their pathogens	33
Machine learning for target discovery in drug development	33
Chemiluminescent spiroadamantane-1,2-dioxetanes: Recent advances in molecular imaging and biomarker detection	31
SOD mimics: From the tool box of the chemists to cellular studies	31
Recent progress in metal-based molecular probes for optical bioimaging and biosensing	31
Toward synthetic life: Biomimetic synthetic cell communication	31
Molecular mechanisms of microbial transmembrane electron transfer of electrochemically active bacteria	31
Enzyme evolution in natural products biosynthesis: target- or diversity-oriented?	30
Two-hit wonders: The expanding universe of multitargeting epigenetic agents	30

Natural, modified DNA bases	29
Recent advance in the biosynthesis of nitrogen–nitrogen bond–containing natural products	29
Current state on the enzymatic synthesis of glycosaminoglycans	29
Expanding the applicability of cytochrome P450s and other haemoproteins	29
Chemical biology of protein citrullination by the protein A arginine deiminases	28
Inhibitors of DHHC family proteins	28
Engineering Clostridium ljungdahlii as the gas-fermenting cell factory for the production of biofuels and biochemicals	28
Mass spectrometry techniques for imaging and detection of metallodrugs	28
Potential-dependent extracellular electron transfer pathways of exoelectrogens	27
Not so innocent: Impact of fluorophore chemistry on the in vivo properties of bioconjugates	27
Recent advances in drug repurposing using machine learning	26
Advances in theranostic biomarkers for tumor immunotherapy	25
Caged lipids for subcellular manipulation	25
The chemical biology of hydrogen sulfide and related hydropersulfides: interactions with biologically relevant metals and metalloproteins	25
Systems for in vivo hypermutation: a quest for scale and depth in directed evolution	25
Synthetic biomolecular condensates to engineer eukaryotic cells	24
Photocaged functional nucleic acids for spatiotemporal imaging in biology	24
Rewiring yeast metabolism to synthesize products beyond ethanol	24
Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins	24
Designer metalloenzymes for synthetic biology: Enzyme hybrids for catalysis	24
Supramolecular coordination complexes as diagnostic and therapeutic agents	24
Metallo-β-lactamases and a tug-of-war for the available zinc at the host–pathogen interface	23
Current strategies for characterization of mucin-domain glycoproteins	23
Biogenesis of the peptide-derived redox cofactor pyrroloquinoline quinone	23
Revealing the functional roles of tyrosine sulfation using synthetic sulfopeptides and sulfoproteins	23
Exploring amyloid oligomers with peptide model systems	23
Recent progress in chemical synthesis of bacterial surface glycans	22
Adenosylation reactions catalyzed by the radical S-adenosylmethionine superfamily enzymes	22
Non-conventional hosts for the production of fuels and chemicals	22
Connecting chemistry and biology through molecular descriptors	22
Metal complexes as optical probes for DNA sensing and imaging	22
Deciphering combinatorial post-translational modifications by top-down mass spectrometry	21
Synthetic biology for natural product drug production and engineering	21
New strategies for fluorescently labeling proteins in the study of amyloids	21
Zinc homeostasis in the secretory pathway in yeast	21
Enhancing native chemical ligation for challenging chemical protein syntheses	21
Imaging organelle membranes in live cells at the nanoscale with lipid-based fluorescent probes	21
Current processes and future challenges of photoautotrophic production of acetyl-CoA-derived solar fuels and chemicals in cyanobacteria	20
Engineered biosynthetic pathways and biocatalytic cascades for sustainable synthesis	20
Biosynthesis of marine toxins	20
Targeting epigenetic reader domains by chemical biology	20
Enzyme-targeted fluorescent small-molecule probes for bacterial imaging	20
Imaging voltage and brain chemistry with genetically encoded sensors and modulators	20
Chemical synthesis of polysaccharides	19
Natural and engineered transglycosylases: Green tools for the enzyme-based synthesis of glycoproducts	19
Strategies and open questions in solid-phase protein chemical synthesis	19
All-atom simulations to studying metallodrugs/target interactions	19
In silico, in vitro, and in vivo machine learning in synthetic biology and metabolic engineering	19
Sensing cellular biochemistry with fluorescent chemical–genetic hybrids	19
Advanced functional fluorescent probes for cell plasma membranes	19
Emerging chelators for nuclear imaging	18
Understanding and controlling amyloid aggregation with chirality	18
Recent advances in glycan synthesis	18
Sequencing enabling design and learning in synthetic biology	18
Reducing the renal retention of low- to moderate-molecular-weight radiopharmaceuticals	18
Substrates and interactors of the ClpP protease in the mitochondria	18
Tailoring microbes to upgrade lignin	18
Advances in imaging of understudied ions in signaling: A focus on magnesium	18
Quantitative interactome analysis with chemical cross-linking and mass spectrometry	18
Acoustic-based chemical tools for profiling the tumor microenvironment	18
From structure to application: Progress and opportunities in peptide materials development	18
Integrated molecular imaging technologies for investigation of metals in biological systems: A brief review	17
Advances in visualization of copper in mammalian systems using X-ray fluorescence microscopy	17
New strategies to identify protease substrates	17
Mechanosensitive channels of Corynebacterium glutamicum functioning as exporters of l-glutamate and other valuable metabolites	17
Highlighting the roles of transition metals and speciation in chemical biology	17
Molecular simulations of complex carbohydrates and glycoconjugates	16
Mapping messenger RNA methylations at single base resolution	16
Critical considerations in N-glycoproteomics	16
Imaging mRNA trafficking in living cells using fluorogenic proteins	16
Versatile signaling mechanisms of inositol pyrophosphates	16
Past, present, and perspectives of protein N-terminal methylation	16
Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo	16
Photoaffinity labeling approaches to elucidate lipid–protein interactions	15
Increasing the chemical space of proteins in living cells via genetic code expansion	15
Catalytic amyloids: Is misfolding folding?	15
Metal-based environment-sensitive MRI contrast agents	15
Phospholipid-coated targeted microbubbles for ultrasound molecular imaging and therapy	15
Targeting mutant KRAS	15
Chemogenetic and optogenetic control of post-translational modifications through genetic code expansion	15

Chemical biology of noncanonical G protein–coupled receptor signaling: Toward advanced therapeutics	15
Metabolite assemblies: A surprising extension to the amyloid hypothesis	15
Mitochondria as a target of third row transition metal-based anticancer complexes	15
Molecular probes for fluorescence image-guided cancer surgery	15
A critical evaluation of probes for cysteine sulfenic acid	15
The advent of de novo proteins for cancer immunotherapy	15
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean	14
Improved methods for targeting epigenetic reader domains of acetylated and methylated lysine	14
Synthetic biology enabling access to designer polyketides	14
Recent advances in functional analysis of polyunsaturated fatty acid synthases	14
Recent advances in polysaccharide-based in situ forming hydrogels	14
Emerging frontiers in virtual drug discovery: From quantum mechanical methods to deep learning approaches	14
Chemical regulation of the cGAS-STING pathway	14
Stereo-electronic control of reaction selectivity in short-chain dehydrogenases: Decarboxylation, epimerization, and dehydration	14
Molecular evolution and functional divergence of UDP-hexose 4-epimerases	14
Peptides for disrupting and degrading amyloids	14
Designed protease-based signaling networks	13
Recent advances in induced proximity modalities	13
Characterising biomolecular interactions and dynamics with mass photometry	13
Genetically encoding latent bioreactive amino acids and the development of covalent protein drugs	13
Small-angle X-ray scattering studies of enzymes	13
Advances and challenges in epigenomic single-cell sequencing applications	12
Promising heterometallic compounds as anticancer agents: Recent studies in vivo	12
Progress toward the development of the small molecule equivalent of small interfering RNA	12
Recent advances in mass spectrometry-based computational metabolomics	12
Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds	12
Recent developments in ligands and chemical probes targeting solute carrier transporters	12
The chemical biology of NAD+ regulation in axon degeneration	12
Emerging role of ferrous iron in bacterial growth and host–pathogen interaction: New tools for chemical (micro)biology and antibacterial therapy	12
The ubiquitin proteoform problem	12
Network biology bridges the gaps between quantitative genetics and multi-omics to map complex diseases	12
Molecular glues to stabilise protein–protein interactions	12
Dissecting the copper bioinorganic chemistry of the functional and pathological roles of the prion protein: Relevance in Alzheimer's disease and cancer	12
Imaging-guided nanomedicine development	12
Inhibition of p53 protein aggregation as a cancer treatment strategy	11
Metallomics and other omics approaches in antiparasitic metal-based drug research	11
Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF	11
Extendable and explainable deep learning for pan-cancer radiogenomics research	11
The catalytic mechanism of sulfoxide synthases	11
Exploitation of carbohydrate processing enzymes in biocatalysis	11
Beyond mere DNA damage: Recent progress in platinum(IV) anticancer complexes containing multi-functional axial ligands	11
Recent advances in intravital microscopy for preclinical research	11
Emerging chemistry and biology in protein glutathionylation	11
Methods to identify protein targets of metal-based drugs	11
Chemical probes for tagging mycobacterial lipids	11
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region	11
Targeting of extracellular protein–protein interactions with macrocyclic peptides	10
Inverse Drug Discovery identifies weak electrophiles affording protein conjugates	10
Drugging the gut microbiota: toward rational modulation of bacterial composition in the gut	10
Bioaldehydes and beyond: Expanding the realm of bioderived chemicals using biogenic aldehydes as platforms	10
Emerging roles of O-glycosylation in regulating protein aggregation, phase separation, and functions	10
Recent advances in computational algorithms and software for large-scale glycoproteomics	10
Thermal proteome profiling: Insights into protein modifications, associations, and functions	10
Drugging the undruggable proteins in cancer: A systems biology approach	10
Machine learning for profile prediction in genomics	10
Application of X-ray absorption and X-ray fluorescence techniques to the study of metallodrug action	10
Induced proximity tools for precise manipulation of lipid signaling	10
Deuterium Raman imaging for lipid analysis	10
Direct visualization and profiling of protein misfolding and aggregation in live cells	9
‘Design, synthesis, and strategic use of small chemical probes toward identification of novel targets for drug development’	9
Crystallography of polysaccharides: Current state and challenges	9
Lipidomics analysis in drug discovery and development	9
Chemical and optical control of CRISPR-associated nucleases	9
Patient-derived model systems and the development of next-generation anticancer therapeutics	9
Toolbox for chemically synthesized histone proteins	9
Supramolecular glycopolymers: How carbohydrates matter in structure, dynamics, and function	9
Domain cross-talk in regulation of histone modifications: Molecular mechanisms and targeting opportunities	9
Shedding light on current trends in molecular optogenetics	9
Chemoenzymatic strategies for RNA modification and labeling	9
Emerging mammalian gene switches for controlling implantable cell therapies	9
Advances in membrane mimetics and mass spectrometry for understanding membrane structure and function	9
Consequences of post-translational modifications on amyloid proteins as revealed by protein semisynthesis	9
Taming glutathione potentiates metallodrug action	8
Sulfoxides in medicine	8
Fluorescent probes for investigating peptidoglycan biosynthesis in mycobacteria	8
Toward enhanced performance of integrated photo-bioelectrochemical systems: Taxa and functions in bacteria–algae communities	8
Multi-omics approaches to study platelet mechanisms	8
Probing immune infiltration dynamics in cancer by in vivo imaging	8
KATs off: Biomedical insights from lysine acetyltransferase inhibitors	8
Protein engineering for selective proteomics	8
Chemical approaches for investigating site-specific protein S-fatty acylation	7
Computational modeling of carbohydrate processing enzymes reactions	7
Electrogenetics: Bridging synthetic biology and electronics to remotely control the behavior of mammalian designer cells	7
Current mechanistic understanding of intermembrane lipid trafficking important for maintenance of bacterial outer membrane lipid asymmetry	7
Bromodomain inhibitors and therapeutic applications	7
Mechanism and inhibition of BRAF kinase	7
Coupling chemical biology and vibrational spectroscopy for studies of amyloids in vitro and in cells	7
Deconvoluting the biology and druggability of protein lipidation using chemical proteomics	7
Recent advances in dissecting the demethylation reactions in natural product biosynthesis	7
Super-multiplexed vibrational probes: Being colorful makes a difference	7
Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine	7
Chemistry and biology of enzymes in protein glutathionylation	7
Recent advances on human milk oligosaccharide antimicrobial activity	7
NMR spectroscopy to study the fate of metallodrugs in cells	7
A chemical field guide to histone nonenzymatic modifications	7