OOIR: Observatory of International Research

Papers

(The H4-Index of Current Opinion in Chemical Biology is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Machine learning in protein structure prediction	168
Single-cell protein analysis by mass spectrometry	122
Protein sequence design with deep generative models	104
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment	93
Recent developments in bioorthogonal chemistry and the orthogonality within	92
Transition metal catalysts for the bioorthogonal synthesis of bioactive agents	84
Activity- and reactivity-based proteomics: Recent technological advances and applications in drug discovery	79
Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics	78
Metabolic engineering strategies toward production of biofuels	74
Intrinsically disordered proteins and biomolecular condensates as drug targets	71
Image-based cell phenotyping with deep learning	70
Structure-based protein design with deep learning	67
The blind men and the filament: Understanding structures and functions of microbial nanowires	67
Targeting Son of Sevenless 1: The pacemaker of KRAS	60
BET bromodomain inhibitors	58
Siglec and anti-Siglec therapies	57
Protein metalation in biology	54
Anatomy of a crosslinker	53
Emerging tools for bioluminescence imaging	51
Chemiluminescent spiroadamantane-1,2-dioxetanes: Recent advances in molecular imaging and biomarker detection	49
The rise of covalent proteolysis targeting chimeras	48
Directed evolution for enzyme development in biocatalysis	48
SOD mimics: From the tool box of the chemists to cellular studies	47
Natural product discovery through microbial genome mining	46
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	46

New approaches to target RNA binding proteins	45
Recent progress on the prospective application of machine learning to structure-based virtual screening	45
New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance	44
Recent progress in synthesis of carbohydrates with sugar nucleotide-dependent glycosyltransferases	44
Shewanella biofilm development and engineering for environmental and bioenergy applications	43
Cytokine engineering for targeted cancer immunotherapy	43
Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment	41
Current state on the enzymatic synthesis of glycosaminoglycans	41
Enzyme evolution in natural products biosynthesis: target- or diversity-oriented?	40
Recent advances in mass spectrometry–based peptidomics workflows to identify short-open-reading-frame-encoded peptides and explore their functions	40
Molecular mechanisms of microbial transmembrane electron transfer of electrochemically active bacteria	39
Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes	39
Supramolecular metal-based nanoparticles for drug delivery and cancer therapy	39
Recent progress in metal-based molecular probes for optical bioimaging and biosensing	38