OOIR: Observatory of International Research

Papers

(The H4-Index of Current Opinion in Chemical Biology is 39. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?	220
Machine learning in protein structure prediction	136
Single-cell protein analysis by mass spectrometry	105
Biocatalysis in drug discovery and development	103
Protein immobilization technology for flow biocatalysis	96
Recent advances of thiol-selective bioconjugation reactions	93
Emerging strategies for expanding the toolbox of enzymes in biocatalysis	85
Protein sequence design with deep generative models	85
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment	79
Recent developments in bioorthogonal chemistry and the orthogonality within	77
Targeted protein degradation: current and future challenges	73
Bacterial enzymes for lignin depolymerisation: new biocatalysts for generation of renewable chemicals from biomass	72
Activity- and reactivity-based proteomics: Recent technological advances and applications in drug discovery	70
Transition metal catalysts for the bioorthogonal synthesis of bioactive agents	69
Recent achievements and current trajectories of diversity-oriented synthesis	68
Pictet–Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis	65
Recent progress in the development of organometallics for the treatment of cancer	65
Integrating biocatalysis with chemocatalysis for selective transformations	62
The blind men and the filament: Understanding structures and functions of microbial nanowires	61
Intrinsically disordered proteins and biomolecular condensates as drug targets	58
Metabolic engineering strategies toward production of biofuels	58
Image-based cell phenotyping with deep learning	55
Advances of epigenetic editing	53
How synthetic biology can help bioremediation	52
Targeting Son of Sevenless 1: The pacemaker of KRAS	52

Structure-based protein design with deep learning	51
Inhibitors of the mitochondrial calcium uniporter for the treatment of disease	49
Mammalian iron–sulfur cluster biogenesis: Recent insights into the roles of frataxin, acyl carrier protein and ATPase-mediated transfer to recipient proteins	48
Anatomy of a crosslinker	47
Siglec and anti-Siglec therapies	47
Recent advances in the chemoenzymatic synthesis of bioactive natural products	46
The rise of covalent proteolysis targeting chimeras	45
Proteolysis targeting chimeras (PROTACs) for epigenetics research	45
Emerging tools for bioluminescence imaging	43
Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery	43
Metalloproteomics in conjunction with other omics for uncovering the mechanism of action of metallodrugs: Mechanism-driven new therapy development	43
Exploiting azide–alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes	42
Gold compounds for catalysis and metal-mediated transformations in biological systems	41
Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?	40
Natural product discovery through microbial genome mining	39
Domain-selective targeting of BET proteins in cancer and immunological diseases	39
Drugging histone methyltransferases in cancer	39
BET bromodomain inhibitors	39
Protein metalation in biology	39
Shewanella biofilm development and engineering for environmental and bioenergy applications	39