Critical Care

Papers
(The TQCC of Critical Care is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
ArticleCitations
Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19730
Acute respiratory failure in COVID-19: is it “typical” ARDS?466
COVID-19 pneumonia: ARDS or not?452
The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection372
The unique characteristics of COVID-19 coagulopathy346
COVID-19: ICU delirium management during SARS-CoV-2 pandemic339
Psychological stress of ICU nurses in the time of COVID-19295
Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019— results from a systematic review and meta-analysis290
Incidence of ARDS and outcomes in hospitalized patients with COVID-19: a global literature survey279
Biomarkers of sepsis: time for a reappraisal277
Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China253
Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients238
Corticosteroid use in COVID-19 patients: a systematic review and meta-analysis on clinical outcomes234
Can artificial intelligence help for scientific writing?234
Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients223
Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis220
Clinical determinants for fatality of 44,672 patients with COVID-19201
Ventilator-associated pneumonia in critically ill patients with COVID-19197
Prediction of the development of acute kidney injury following cardiac surgery by machine learning190
Emerging SARS-CoV-2 variants of concern and potential intervention approaches179
Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis178
Mortality rates of patients with COVID-19 in the intensive care unit: a systematic review of the emerging literature177
Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury170
Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19170
Revisited: Therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics159
Effect of timing of intubation on clinical outcomes of critically ill patients with COVID-19: a systematic review and meta-analysis of non-randomized cohort studies157
Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients155
Clinical ethics recommendations for the allocation of intensive care treatments in exceptional, resource-limited circumstances: the Italian perspective during the COVID-19 epidemic155
Thrombotic and hemorrhagic events in critically ill COVID-19 patients: a French monocenter retrospective study151
The gut microbiome’s role in the development, maintenance, and outcomes of sepsis150
Acute kidney injury in SARS-CoV-2 infected patients148
Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China146
A new clinical trial to test high-dose vitamin C in patients with COVID-19145
Acute complications and mortality in hospitalized patients with coronavirus disease 2019: a systematic review and meta-analysis140
Prevalence and impact of acute renal impairment on COVID-19: a systematic review and meta-analysis133
The association of low serum albumin level with severe COVID-19: a systematic review and meta-analysis132
Patients with COVID-19 in 19 ICUs in Wuhan, China: a cross-sectional study130
High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure129
SARS-CoV-2 viral load in sputum correlates with risk of COVID-19 progression127
Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review124
Soluble urokinase plasminogen activator receptor (suPAR) as an early predictor of severe respiratory failure in patients with COVID-19 pneumonia124
Neurological manifestations of COVID-19: a systematic review123
Respiratory physiology of COVID-19-induced respiratory failure compared to ARDS of other etiologies119
Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method116
COVID-19 and ECMO: the interplay between coagulation and inflammation—a narrative review115
Severe manifestations of SARS-CoV-2 in children and adolescents: from COVID-19 pneumonia to multisystem inflammatory syndrome: a multicentre study in pediatric intensive care units in Spain115
Long-term outcomes after critical illness: recent insights115
Herpes simplex virus and cytomegalovirus reactivations among severe COVID-19 patients115
A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19114
Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China113
Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring108
Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study108
The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition106
Dangers of hyperoxia106
Elevation of plasma angiotensin II level is a potential pathogenesis for the critically ill COVID-19 patients105
High-density lipoproteins during sepsis: from bench to bedside105
Nutrition of the COVID-19 patient in the intensive care unit (ICU): a practical guidance104
Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series104
Incidence of acute kidney injury in COVID-19 infection: a systematic review and meta-analysis102
Thrombotic and haemorrhagic complications in critically ill patients with COVID-19: a multicentre observational study99
Age and sex differences in soluble ACE2 may give insights for COVID-1999
Lung ultrasound findings in patients with COVID-19 pneumonia95
Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intens95
The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study95
Ethics guidelines on COVID-19 triage—an emerging international consensus94
Personalized mechanical ventilation in acute respiratory distress syndrome94
Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study92
Risks of ventilator-associated pneumonia and invasive pulmonary aspergillosis in patients with viral acute respiratory distress syndrome related or not to Coronavirus 19 disease92
Markers of endothelial and epithelial pulmonary injury in mechanically ventilated COVID-19 ICU patients90
Comparison between first and second wave among critically ill COVID-19 patients admitted to a French ICU: no prognostic improvement during the second wave?90
Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus87
Early awake prone position combined with high-flow nasal oxygen therapy in severe COVID-19: a case series86
Update of the treatment of nosocomial pneumonia in the ICU85
A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection85
Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome85
Preparing your intensive care unit for the COVID-19 pandemic: practical considerations and strategies84
Prolonged prone position ventilation for SARS-CoV-2 patients is feasible and effective84
Adjuvant corticosteroid therapy for critically ill patients with COVID-1983
Atorvastatin associated with decreased hazard for death in COVID-19 patients admitted to an ICU: a retrospective cohort study83
Clinical characteristics of invasive pulmonary aspergillosis in patients with COVID-19 in Zhejiang, China: a retrospective case series81
Platelet-derived exosomes promote neutrophil extracellular trap formation during septic shock81
Persistent hypermetabolism and longitudinal energy expenditure in critically ill patients with COVID-1980
Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial80
Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: a retrospective case series80
The role of telemedicine during the COVID-19 epidemic in China—experience from Shandong province79
Acute skeletal muscle wasting and dysfunction predict physical disability at hospital discharge in patients with critical illness79
Brain–heart interaction after acute ischemic stroke79
Gut-liver crosstalk in sepsis-induced liver injury79
Neutrophil-to-lymphocyte ratio as a predictive biomarker for moderate-severe ARDS in severe COVID-19 patients78
Epidemiology and microbiology of ventilator-associated pneumonia in COVID-19 patients: a multicenter retrospective study in 188 patients in an un-inundated French region78
Mechanical ventilation parameters in critically ill COVID-19 patients: a scoping review78
COVID-19 and the RAAS—a potential role for angiotensin II?77
Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence76
Molecular mechanisms of sex bias differences in COVID-19 mortality76
VEGF-D: a novel biomarker for detection of COVID-19 progression76
Right ventricular-arterial uncoupling independently predicts survival in COVID-19 ARDS76
Prehospital pulse oximetry: a red flag for early detection of silent hypoxemia in COVID-19 patients75
Thromboembolic complications in critically ill COVID-19 patients are associated with impaired fibrinolysis75
Body temperature correlates with mortality in COVID-19 patients75
Prognostic value of bedside lung ultrasound score in patients with COVID-1974
Effect of mechanical power on intensive care mortality in ARDS patients74
Comparison of published guidelines for management of coagulopathy and thrombosis in critically ill patients with COVID 19: implications for clinical practice and future investigations72
Blocking IL-1 to prevent respiratory failure in COVID-1971
Systemic hypoferremia and severity of hypoxemic respiratory failure in COVID-1971
How to measure blood pressure using an arterial catheter: a systematic 5-step approach71
Multimodal non-invasive assessment of intracranial hypertension: an observational study69
CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS68
COVID-19: a hypothesis regarding the ventilation-perfusion mismatch67
Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT)67
Infliximab against severe COVID-19-induced cytokine storm syndrome with organ failure—a cautionary case series67
Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort67
The impact of COVID-19 critical illness on new disability, functional outcomes and return to work at 6 months: a prospective cohort study66
Right ventricular failure in septic shock: characterization, incidence and impact on fluid responsiveness65
Bedside calculation of mechanical power during volume- and pressure-controlled mechanical ventilation65
Hemophagocytic lymphohistiocytosis in critically ill patients: diagnostic reliability of HLH-2004 criteria and HScore65
Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis64
COVID-19 mortality and ICU admission: the Italian experience63
The use of venous Doppler to predict adverse kidney events in a general ICU cohort63
Machine learning model for early prediction of acute kidney injury (AKI) in pediatric critical care62
Antifungal prophylaxis for prevention of COVID-19-associated pulmonary aspergillosis in critically ill patients: an observational study62
Dosing of thromboprophylaxis and mortality in critically ill COVID-19 patients61
Performance and impact of a multiplex PCR in ICU patients with ventilator-associated pneumonia or ventilated hospital-acquired pneumonia61
Co-infections in COVID-19 critically ill and antibiotic management: a prospective cohort analysis61
Machine-learning-based COVID-19 mortality prediction model and identification of patients at low and high risk of dying60
Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial60
Extracorporeal cardiopulmonary resuscitation in adult patients with out-of-hospital cardiac arrest: a retrospective large cohort multicenter study in Japan59
Incidence and mortality of pulmonary embolism in COVID-19: a systematic review and meta-analysis59
Initial antimicrobial management of sepsis58
Heating, ventilation and air conditioning (HVAC) in intensive care unit58
Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-1958
Administration of umbilical cord mesenchymal stem cells in patients with severe COVID-19 pneumonia57
Timing of norepinephrine initiation in patients with septic shock: a systematic review and meta-analysis57
Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs57
High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non-inferiority randomized trial57
Noninvasive respiratory support outside the intensive care unit for acute respiratory failure related to coronavirus-19 disease: a systematic review and meta-analysis56
Early corticosteroids are associated with lower mortality in critically ill patients with COVID-19: a cohort study56
Admission decisions to intensive care units in the context of the major COVID-19 outbreak: local guidance from the COVID-19 Paris-region area56
The effect of higher versus lower protein delivery in critically ill patients: a systematic review and meta-analysis of randomized controlled trials56
Deploying unsupervised clustering analysis to derive clinical phenotypes and risk factors associated with mortality risk in 2022 critically ill patients with COVID-19 in Spain55
Helmet CPAP to treat hypoxic pneumonia outside the ICU: an observational study during the COVID-19 outbreak55
Timing of antibiotic therapy in the ICU54
Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia54
Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI54
Prevalence of post-intensive care syndrome among Japanese intensive care unit patients: a prospective, multicenter, observational J-PICS study54
ECMO use in COVID-19: lessons from past respiratory virus outbreaks—a narrative review54
Auxora versus standard of care for the treatment of severe or critical COVID-19 pneumonia: results from a randomized controlled trial53
Computed tomography assessment of PEEP-induced alveolar recruitment in patients with severe COVID-19 pneumonia53
Systematic early versus late mobilization or standard early mobilization in mechanically ventilated adult ICU patients: systematic review and meta-analysis53
Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis53
Resuscitation fluid types in sepsis, surgical, and trauma patients: a systematic review and sequential network meta-analyses52
Two subphenotypes of septic acute kidney injury are associated with different 90-day mortality and renal recovery52
Large language models and the perils of their hallucinations51
High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: a multicenter, randomized controlled trial51
International variation in the management of severe COVID-19 patients51
Association between perioperative fluid administration and postoperative outcomes: a 20-year systematic review and a meta-analysis of randomized goal-directed trials in major visceral/noncardiac surge50
Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times?50
Hemoperfusion: technical aspects and state of the art50
Evolving outcomes of extracorporeal membrane oxygenation support for severe COVID-19 ARDS in Sorbonne hospitals, Paris50
The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis50
The challenge of ventilator-associated pneumonia diagnosis in COVID-19 patients50
Blood purification with a cytokine adsorber for the elimination of myoglobin in critically ill patients with severe rhabdomyolysis49
Complete countrywide mortality in COVID patients receiving ECMO in Germany throughout the first three waves of the pandemic49
Development and validation of a risk factor-based system to predict short-term survival in adult hospitalized patients with COVID-19: a multicenter, retrospective, cohort study49
The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: a subgroup analysis of the Sedation Practice in Intensive Care Evaluation [SPICE III] Trial49
Managing COVID-19 in resource-limited settings: critical care considerations49
Blood purification therapy with a hemodiafilter featuring enhanced adsorptive properties for cytokine removal in patients presenting COVID-19: a pilot study49
Brain tight junction protein expression in sepsis in an autopsy series48
Monocyte distribution width (MDW) performance as an early sepsis indicator in the emergency department: comparison with CRP and procalcitonin in a multicenter international European prospective study48
Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients48
Cardiac injury associated with severe disease or ICU admission and death in hospitalized patients with COVID-19: a meta-analysis and systematic review48
Antibiotic therapeutic drug monitoring in intensive care patients treated with different modalities of extracorporeal membrane oxygenation (ECMO) and renal replacement therapy: a prospective, observat48
The impact of right ventricular injury on the mortality in patients with acute respiratory distress syndrome: a systematic review and meta-analysis47
Cerebral venous sinus thrombosis associated with thrombocytopenia post-vaccination for COVID-1947
Advanced respiratory monitoring in COVID-19 patients: use less PEEP!47
Inhaled nitric oxide in patients admitted to intensive care unit with COVID-19 pneumonia47
A guide to enteral nutrition in intensive care units: 10 expert tips for the daily practice47
Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation47
Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study47
Causes and characteristics of death in patients with acute hypoxemic respiratory failure and acute respiratory distress syndrome: a retrospective cohort study46
ECMO during the COVID-19 pandemic: when is it unjustified?45
Severe Covid-19 disease: rather AVDS than ARDS?45
Prone positioning under VV-ECMO in SARS-CoV-2-induced acute respiratory distress syndrome45
Invasive mechanical ventilation in COVID-19 patient management: the experience with 469 patients in Wuhan44
Vasopressor Choice and Timing in Vasodilatory Shock44
Mortality in septic patients treated with vitamin C: a systematic meta-analysis44
Therapeutic plasma exchange in patients with COVID-19 pneumonia in intensive care unit: a retrospective study44
Efficacy of tocilizumab in patients with COVID-19 ARDS undergoing noninvasive ventilation44
Inhaled nitric oxide for critically ill Covid-19 patients: a prospective study44
Bedside POCUS during ward emergencies is associated with improved diagnosis and outcome: an observational, prospective, controlled study44
Acute kidney injury in ECMO patients44
Recommendations for the use of vascular access in the COVID-19 patients: an Italian perspective43
Argatroban versus heparin in patients without heparin-induced thrombocytopenia during venovenous extracorporeal membrane oxygenation: a propensity-score matched study43
Restricted visitation policies in acute care settings during the COVID-19 pandemic: a scoping review43
Expert clinical pharmacological advice may make an antimicrobial TDM program for emerging candidates more clinically useful in tailoring therapy of critically ill patients43
Artificial Intelligence in Critical Care Medicine43
PEEP levels in COVID-19 pneumonia43
Plasma exchange in critically ill COVID-19 patients43
Should we deny ICU admission to the elderly? Ethical considerations in times of COVID-1942
The therapeutic efficacy of adjunct therapeutic plasma exchange for septic shock with multiple organ failure: a single-center experience42
Recommendations for core critical care ultrasound competencies as a part of specialist training in multidisciplinary intensive care: a framework proposed by the European Society of Intensive Care Medi41
Venoarterial extracorporeal membrane oxygenation as mechanical circulatory support in adult septic shock: a systematic review and meta-analysis with individual participant data meta-regression analysi41
Identification and characterization of neutrophil heterogeneity in sepsis41
Energy delivery guided by indirect calorimetry in critically ill patients: a systematic review and meta-analysis41
Prone positioning in severe ARDS requiring extracorporeal membrane oxygenation41
Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study41
Coagulation phenotypes in sepsis and effects of recombinant human thrombomodulin: an analysis of three multicentre observational studies41
Staphylococcus aureus ventilator-associated pneumonia in patients with COVID-19: clinical features and potential inference with lung dysbiosis41
Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial41
Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial40
Drug dosing in the critically ill obese patient—a focus on sedation, analgesia, and delirium40
Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis40
VENTILatOry strategies in patients with severe traumatic brain injury: the VENTILO Survey of the European Society of Intensive Care Medicine (ESICM)40
Ventilator-associated pneumonia in the era of COVID-19 pandemic: How common and what is the impact?40
EXpert consensus On Diaphragm UltraSonography in the critically ill (EXODUS): a Delphi consensus statement on the measurement of diaphragm ultrasound-derived parameters in a critical care setting40
How COVID-19 pandemic changed our communication with families: losing nonverbal cues40
Role of endothelial miR-24 in COVID-19 cerebrovascular events39
Sex differences in survival after out-of-hospital cardiac arrest: a meta-analysis39
Early effects of ventilatory rescue therapies on systemic and cerebral oxygenation in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome: a prospective observational st39
Unmatched ventilation and perfusion measured by electrical impedance tomography predicts the outcome of ARDS39
The epidemiology and clinical outcomes of ventilator-associated events among 20,769 mechanically ventilated patients at intensive care units: an observational study39
Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients39
Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study39
HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients39
Recommendations for hemodynamic monitoring for critically ill children—expert consensus statement issued by the cardiovascular dynamics section of the European Society of Paediatric and Neonatal Inten39
Neutrophil Elastase Inhibitors: A potential prophylactic treatment option for SARS-CoV-2-induced respiratory complications?39
“War to the knife” against thromboinflammation to protect endothelial function of COVID-19 patients38
A systematic review of biomarkers multivariately associated with acute respiratory distress syndrome development and mortality38
Early individualized positive end-expiratory pressure guided by electrical impedance tomography in acute respiratory distress syndrome: a randomized controlled clinical trial38
Machine learning identifies ICU outcome predictors in a multicenter COVID-19 cohort38
Neuromuscular blocking agents (NMBA) for COVID-19 acute respiratory distress syndrome: a multicenter observational study38
Extracorporeal versus conventional cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest: a secondary analysis of the Prague OHCA trial38
Development of a work of breathing scale and monitoring need of intubation in COVID-19 pneumonia38
The fluid challenge38
Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis38
Outbreak of Pseudomonas aeruginosa producing VIM carbapenemase in an intensive care unit and its termination by implementation of waterless patient care37
Corticosteroids as risk factor for COVID-19-associated pulmonary aspergillosis in intensive care patients37
Different applications of the KDIGO criteria for AKI lead to different incidences in critically ill patients: a post hoc analysis from the prospective observational SICS-II study37
Lung distribution of gas and blood volume in critically ill COVID-19 patients: a quantitative dual-energy computed tomography study37
Association between mean arterial pressure during the first 24 hours and hospital mortality in patients with cardiogenic shock37
Significance of body temperature in elderly patients with sepsis37
Time-to-antibiotics and clinical outcomes in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study37
Severe pulmonary embolism in COVID-19 patients: a call for increased awareness37
Frailty, delirium and hospital mortality of older adults admitted to intensive care: the Delirium (Deli) in ICU study37
Corticosteroid therapy for coronavirus disease 2019-related acute respiratory distress syndrome: a cohort study with propensity score analysis37
Brain–lung interactions and mechanical ventilation in patients with isolated brain injury37
Efficacy of tocilizumab treatment in severely ill COVID-19 patients36
Prone positioning combined with high-flow nasal or conventional oxygen therapy in severe Covid-19 patients36
Nasopharyngeal viral load predicts hypoxemia and disease outcome in admitted COVID-19 patients36
Effect of favipiravir and an anti-inflammatory strategy for COVID-1936
Postoperative hypotension in patients discharged to the intensive care unit after non-cardiac surgery is associated with adverse clinical outcomes36
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