OOIR: Observatory of International Research

Papers

(The median citation count of Critical Care is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Can artificial intelligence help for scientific writing?	316
Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis	242
Corticosteroid use in COVID-19 patients: a systematic review and meta-analysis on clinical outcomes	242
Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury	225
Ventilator-associated pneumonia in critically ill patients with COVID-19	205
Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis	194
Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review	193
Emerging SARS-CoV-2 variants of concern and potential intervention approaches	187
The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition	181
Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19	179
Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients	176
Effect of timing of intubation on clinical outcomes of critically ill patients with COVID-19: a systematic review and meta-analysis of non-randomized cohort studies	167
Long-term outcomes after critical illness: recent insights	145
High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure	139
Dangers of hyperoxia	130
Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method	122
Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study	119
Severe manifestations of SARS-CoV-2 in children and adolescents: from COVID-19 pneumonia to multisystem inflammatory syndrome: a multicentre study in pediatric intensive care units in Spain	119
Personalized mechanical ventilation in acute respiratory distress syndrome	111
The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study	104
Large language models and the perils of their hallucinations	102
Markers of endothelial and epithelial pulmonary injury in mechanically ventilated COVID-19 ICU patients	99
The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis	99
Risks of ventilator-associated pneumonia and invasive pulmonary aspergillosis in patients with viral acute respiratory distress syndrome related or not to Coronavirus 19 disease	97
Acute skeletal muscle wasting and dysfunction predict physical disability at hospital discharge in patients with critical illness	97

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study	96
Comparison between first and second wave among critically ill COVID-19 patients admitted to a French ICU: no prognostic improvement during the second wave?	95
Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus	94
Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial	92
Gut-liver crosstalk in sepsis-induced liver injury	91
Machine learning model for early prediction of acute kidney injury (AKI) in pediatric critical care	87
Mechanical ventilation parameters in critically ill COVID-19 patients: a scoping review	85
Right ventricular-arterial uncoupling independently predicts survival in COVID-19 ARDS	84
Epidemiology and microbiology of ventilator-associated pneumonia in COVID-19 patients: a multicenter retrospective study in 188 patients in an un-inundated French region	83
Prognostic value of bedside lung ultrasound score in patients with COVID-19	82
Initial antimicrobial management of sepsis	80
Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis	79
Extracorporeal cardiopulmonary resuscitation in adult patients with out-of-hospital cardiac arrest: a retrospective large cohort multicenter study in Japan	79
The impact of COVID-19 critical illness on new disability, functional outcomes and return to work at 6 months: a prospective cohort study	78
Thromboembolic complications in critically ill COVID-19 patients are associated with impaired fibrinolysis	77
Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis	75
Virtual and augmented reality in critical care medicine: the patient’s, clinician’s, and researcher’s perspective	74
Right ventricular failure in septic shock: characterization, incidence and impact on fluid responsiveness	74
Hemoperfusion: technical aspects and state of the art	74
The use of venous Doppler to predict adverse kidney events in a general ICU cohort	73
CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS	73
Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort	71
Antifungal prophylaxis for prevention of COVID-19-associated pulmonary aspergillosis in critically ill patients: an observational study	71
Timing of antibiotic therapy in the ICU	70
Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial	69
Artificial Intelligence in Critical Care Medicine	69
High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non-inferiority randomized trial	67
Prevalence of post-intensive care syndrome among Japanese intensive care unit patients: a prospective, multicenter, observational J-PICS study	66
Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs	66
A guide to enteral nutrition in intensive care units: 10 expert tips for the daily practice	65
Machine-learning-based COVID-19 mortality prediction model and identification of patients at low and high risk of dying	64
Dosing of thromboprophylaxis and mortality in critically ill COVID-19 patients	64
The effect of higher versus lower protein delivery in critically ill patients: a systematic review and meta-analysis of randomized controlled trials	64
Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI	63
Systematic early versus late mobilization or standard early mobilization in mechanically ventilated adult ICU patients: systematic review and meta-analysis	62
Noninvasive respiratory support outside the intensive care unit for acute respiratory failure related to coronavirus-19 disease: a systematic review and meta-analysis	62
Association between perioperative fluid administration and postoperative outcomes: a 20-year systematic review and a meta-analysis of randomized goal-directed trials in major visceral/noncardiac surge	61
The impact of right ventricular injury on the mortality in patients with acute respiratory distress syndrome: a systematic review and meta-analysis	60
Deploying unsupervised clustering analysis to derive clinical phenotypes and risk factors associated with mortality risk in 2022 critically ill patients with COVID-19 in Spain	59
Identification and characterization of neutrophil heterogeneity in sepsis	59
Helmet CPAP to treat hypoxic pneumonia outside the ICU: an observational study during the COVID-19 outbreak	59
Early corticosteroids are associated with lower mortality in critically ill patients with COVID-19: a cohort study	57
Complete countrywide mortality in COVID patients receiving ECMO in Germany throughout the first three waves of the pandemic	57
Evolving outcomes of extracorporeal membrane oxygenation support for severe COVID-19 ARDS in Sorbonne hospitals, Paris	57
The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?	57
Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients	56
Blood purification therapy with a hemodiafilter featuring enhanced adsorptive properties for cytokine removal in patients presenting COVID-19: a pilot study	56
Resuscitation fluid types in sepsis, surgical, and trauma patients: a systematic review and sequential network meta-analyses	56
Monocyte distribution width (MDW) performance as an early sepsis indicator in the emergency department: comparison with CRP and procalcitonin in a multicenter international European prospective study	55
Computed tomography assessment of PEEP-induced alveolar recruitment in patients with severe COVID-19 pneumonia	55

Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis	55
Acute kidney injury in ECMO patients	55
Bedside POCUS during ward emergencies is associated with improved diagnosis and outcome: an observational, prospective, controlled study	55
Venoarterial extracorporeal membrane oxygenation as mechanical circulatory support in adult septic shock: a systematic review and meta-analysis with individual participant data meta-regression analysi	54
Outbreak of Pseudomonas aeruginosa producing VIM carbapenemase in an intensive care unit and its termination by implementation of waterless patient care	54
Antibiotic therapeutic drug monitoring in intensive care patients treated with different modalities of extracorporeal membrane oxygenation (ECMO) and renal replacement therapy: a prospective, observat	54
Blood purification with a cytokine adsorber for the elimination of myoglobin in critically ill patients with severe rhabdomyolysis	54
Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study	54
Efficacy of CytoSorb®: a systematic review and meta-analysis	52
Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times?	52
EXpert consensus On Diaphragm UltraSonography in the critically ill (EXODUS): a Delphi consensus statement on the measurement of diaphragm ultrasound-derived parameters in a critical care setting	52
Vasopressor Choice and Timing in Vasodilatory Shock	52
Restricted visitation policies in acute care settings during the COVID-19 pandemic: a scoping review	51
Extracorporeal versus conventional cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest: a secondary analysis of the Prague OHCA trial	51
Cerebral venous sinus thrombosis associated with thrombocytopenia post-vaccination for COVID-19	51
Effective hemodynamic monitoring	50
Energy delivery guided by indirect calorimetry in critically ill patients: a systematic review and meta-analysis	50
Coagulation phenotypes in sepsis and effects of recombinant human thrombomodulin: an analysis of three multicentre observational studies	49
The future of intensive care: delirium should no longer be an issue	49
Prediction of extubation outcome in critically ill patients: a systematic review and meta-analysis	49
Argatroban versus heparin in patients without heparin-induced thrombocytopenia during venovenous extracorporeal membrane oxygenation: a propensity-score matched study	49
The fluid challenge	49
Expert clinical pharmacological advice may make an antimicrobial TDM program for emerging candidates more clinically useful in tailoring therapy of critically ill patients	48
Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study	48
Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study	48
The epidemiology and clinical outcomes of ventilator-associated events among 20,769 mechanically ventilated patients at intensive care units: an observational study	48
Mortality in septic patients treated with vitamin C: a systematic meta-analysis	48
Brain–lung interactions and mechanical ventilation in patients with isolated brain injury	47
Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial	47
National incidence and mortality of hospitalized sepsis in China	47
Machine learning identifies ICU outcome predictors in a multicenter COVID-19 cohort	46
HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients	46
Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis	46
Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS	46
Clustering identifies endotypes of traumatic brain injury in an intensive care cohort: a CENTER-TBI study	46
Sex differences in survival after out-of-hospital cardiac arrest: a meta-analysis	46
Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial	46
Equilibrating SSC guidelines with individualized care	46
Unmatched ventilation and perfusion measured by electrical impedance tomography predicts the outcome of ARDS	46
The gut–liver axis in sepsis: interaction mechanisms and therapeutic potential	46
A plea for personalization of the hemodynamic management of septic shock	45
Inhaled nitric oxide for critically ill Covid-19 patients: a prospective study	45
COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation	45
Time-to-antibiotics and clinical outcomes in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study	45
Frailty, delirium and hospital mortality of older adults admitted to intensive care: the Delirium (Deli) in ICU study	44
Early individualized positive end-expiratory pressure guided by electrical impedance tomography in acute respiratory distress syndrome: a randomized controlled clinical trial	44
Recommendations for hemodynamic monitoring for critically ill children—expert consensus statement issued by the cardiovascular dynamics section of the European Society of Paediatric and Neonatal Inten	44
Corticosteroids as risk factor for COVID-19-associated pulmonary aspergillosis in intensive care patients	44
Evolving outcomes of extracorporeal membrane oxygenation during the first 2 years of the COVID-19 pandemic: a systematic review and meta-analysis	43
Mechanical circulatory support for refractory out-of-hospital cardiac arrest: a Danish nationwide multicenter study	43
Staphylococcus aureus ventilator-associated pneumonia in patients with COVID-19: clinical features and potential inference with lung dysbiosis	42
Timing of renal replacement therapy initiation for acute kidney injury in critically ill patients: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis	42
Ventilator-associated pneumonia in the era of COVID-19 pandemic: How common and what is the impact?	42
Role of endothelial miR-24 in COVID-19 cerebrovascular events	42
Strategies for lung- and diaphragm-protective ventilation in acute hypoxemic respiratory failure: a physiological trial	42
Artificial hallucination: GPT on LSD?	41
Lung distribution of gas and blood volume in critically ill COVID-19 patients: a quantitative dual-energy computed tomography study	41
Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study	41
Timing and causes of death in severe COVID-19 patients	41
In-hospital cardiac arrest: the state of the art	41
Early effects of ventilatory rescue therapies on systemic and cerebral oxygenation in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome: a prospective observational st	41
Omega-3 fatty acid-containing parenteral nutrition in ICU patients: systematic review with meta-analysis and cost-effectiveness analysis	40
Postoperative hypotension in patients discharged to the intensive care unit after non-cardiac surgery is associated with adverse clinical outcomes	40
Medical nutrition therapy and clinical outcomes in critically ill adults: a European multinational, prospective observational cohort study (EuroPN)	40
Venous return and mean systemic filling pressure: physiology and clinical applications	39
Early versus late awake prone positioning in non-intubated patients with COVID-19	39
Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a pooled individual patient data analysis	39
Promises and challenges of personalized medicine to guide ARDS therapy	39
Association of inflammatory biomarkers with subsequent clinical course in suspected late onset sepsis in preterm neonates	39
Guideline on multimodal rehabilitation for patients with post-intensive care syndrome	39
Infectious disease-associated encephalopathies	39
Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology	39
Correlation of interleukin-6 with Epstein–Barr virus levels in COVID-19	39
Subphenotypes in acute kidney injury: a narrative review	39
Albumin and fibrinogen kinetics in sepsis: a prospective observational study	39
Comparative accuracy of biomarkers for the prediction of hospital-acquired acute kidney injury: a systematic review and meta-analysis	38
Effect of awake prone position on diaphragmatic thickening fraction in patients assisted by noninvasive ventilation for hypoxemic acute respiratory failure related to novel coronavirus disease	38
Corticosteroid therapy for coronavirus disease 2019-related acute respiratory distress syndrome: a cohort study with propensity score analysis	38
Comparison of culture-negative and culture-positive sepsis or septic shock: a systematic review and meta-analysis	38
Association between early nutrition support and 28-day mortality in critically ill patients: the FRANS prospective nutrition cohort study	38

Angiopoietin-2 outperforms other endothelial biomarkers associated with severe acute kidney injury in patients with severe sepsis and respiratory failure	38
Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort	37
Fluid challenge in critically ill patients receiving haemodynamic monitoring: a systematic review and comparison of two decades	37
Electrical impedance tomography to titrate positive end-expiratory pressure in COVID-19 acute respiratory distress syndrome	37
Inhaled liposomal amphotericin-B as a prophylactic treatment for COVID-19-associated pulmonary aspergillosis/aspergillus tracheobronchitis	37
Rationale for sequential extracorporeal therapy (SET) in sepsis	36
Do changes in pulse pressure variation and inferior vena cava distensibility during passive leg raising and tidal volume challenge detect preload responsiveness in case of low tidal volume ventilation	36
The central and biodynamic role of gut microbiota in critically ill patients	36
COVID-19 ARDS is characterized by higher extravascular lung water than non-COVID-19 ARDS: the PiCCOVID study	36
Phenotypes and subphenotypes of delirium: a review of current categorisations and suggestions for progression	36
Sepsis subphenotyping based on organ dysfunction trajectory	35
Trends in the incidence and outcome of sepsis using data from a Japanese nationwide medical claims database-the Japan Sepsis Alliance (JaSA) study group-	35
Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study	35
Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood–brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observati	35
Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2)	35
Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation	35
Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”	35
External validation of urinary C–C motif chemokine ligand 14 (CCL14) for prediction of persistent acute kidney injury	35
Performance of the cuff leak test in adults in predicting post-extubation airway complications: a systematic review and meta-analysis	34
SARS-COV-2 colonizes coronary thrombus and impairs heart microcirculation bed in asymptomatic SARS-CoV-2 positive subjects with acute myocardial infarction	34
CytoSorb hemoperfusion markedly attenuates circulating cytokine concentrations during systemic inflammation in humans in vivo	34
Core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness: an international modified Delphi consensus study evaluation (CONCISE)	34
Propofol and survival: an updated meta-analysis of randomized clinical trials	33
Co-infection and ICU-acquired infection in COVID-19 ICU patients: a secondary analysis of the UNITE-COVID data set	33
Andexanet alfa versus four-factor prothrombin complex concentrate for the reversal of apixaban- or rivaroxaban-associated intracranial hemorrhage: a propensity score-overlap weighted analysis	33
Causes and timing of death in critically ill COVID-19 patients	33
A 5G-powered robot-assisted teleultrasound diagnostic system in an intensive care unit	33
Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study	33
Critical care hepatology: definitions, incidence, prognosis and role of liver failure in critically ill patients	33
Evidence of a wide gap between COVID-19 in humans and animal models: a systematic review	32
Secondary infections in critically ill patients with COVID-19	32
Early versus delayed enteral nutrition in mechanically ventilated patients with circulatory shock: a nested cohort analysis of an international multicenter, pragmatic clinical trial	32
Comparison of anticoagulation strategies for veno-venous ECMO support in acute respiratory failure	32
The future of intensive care: the study of the microcirculation will help to guide our therapies	32
Perioperative liberal versus restrictive fluid strategies and postoperative outcomes: a systematic review and metanalysis on randomised-controlled trials in major abdominal elective surgery	32
Hemofiltration with the Seraph® 100 Microbind® Affinity filter decreases SARS-CoV-2 nucleocapsid protein in critically ill COVID-19 patients	32
Prediction of hypotension events with physiologic vital sign signatures in the intensive care unit	32
Corticosteroid therapy in critically ill patients with COVID-19: a multicenter, retrospective study	32
Artificial intelligence hallucinations	31
Key characteristics impacting survival of COVID-19 extracorporeal membrane oxygenation	31
Impact of exposure time in awake prone positioning on clinical outcomes of patients with COVID-19-related acute respiratory failure treated with high-flow nasal oxygen: a multicenter cohort study	31
Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals	31
Pathophysiology and clinical implications of the veno-arterial PCO2 gap	31
Extracorporeal membrane oxygenation for COVID-19 and influenza H1N1 associated acute respiratory distress syndrome: a multicenter retrospective cohort study	31
An updated “norepinephrine equivalent” score in intensive care as a marker of shock severity	31
Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study	31
Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial	31
How I prescribe continuous renal replacement therapy	30
Omega-6 sparing effects of parenteral lipid emulsions—an updated systematic review and meta-analysis on clinical outcomes in critically ill patients	30
Longitudinal changes in compliance, oxygenation and ventilatory ratio in COVID-19 versus non-COVID-19 pulmonary acute respiratory distress syndrome	30
The impact of wearable continuous vital sign monitoring on deterioration detection and clinical outcomes in hospitalised patients: a systematic review and meta-analysis	30
Myoglobin clearance with continuous veno-venous hemodialysis using high cutoff dialyzer versus continuous veno-venous hemodiafiltration using high-flux dialyzer: a prospective randomized controlled tr	30
An updated HACOR score for predicting the failure of noninvasive ventilation: a multicenter prospective observational study	30
Mechanical power during extracorporeal membrane oxygenation and hospital mortality in patients with acute respiratory distress syndrome	30
Severe acute kidney injury associated with progression of chronic kidney disease after critical COVID-19	30
Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome	30
Continuous renal replacement therapy versus intermittent hemodialysis as first modality for renal replacement therapy in severe acute kidney injury: a secondary analysis of AKIKI and IDEAL-ICU studies	30
Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care	30
Long-term cognitive functioning is impaired in ICU-treated COVID-19 patients: a comprehensive controlled neuropsychological study	30
A new perspective on NO pathway in sepsis and ADMA lowering as a potential therapeutic approach	30
Hemodynamic and anti-inflammatory effects of early esmolol use in hyperkinetic septic shock: a pilot study	30
Impact of treating iron deficiency, diagnosed according to hepcidin quantification, on outcomes after a prolonged ICU stay compared to standard care: a multicenter, randomized, single-blinded trial	30
Prevalence of systemic venous congestion assessed by Venous Excess Ultrasound Grading System (VExUS) and association with acute kidney injury in a general ICU cohort: a prospective multicentric study	29
Automated detection and quantification of reverse triggering effort under mechanical ventilation	29
Corticosteroids in severe COVID-19: a critical view of the evidence	29
Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study	29
Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS	29
Early adjunctive methylene blue in patients with septic shock: a randomized controlled trial	29
Comparison of the predictive ability of clinical frailty scale and hospital frailty risk score to determine long-term survival in critically ill patients: a multicentre retrospective cohort study	29
Distribution of delirium motor subtypes in the intensive care unit: a systematic scoping review	29
Diagnostic accuracy of point-of-care ultrasound for shock: a systematic review and meta-analysis	29
A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients	28
COVID-19: What Iodine Maps From Perfusion CT can reveal—A Prospective Cohort Study	28
Evaluation of inhaled nitric oxide (iNO) treatment for moderate-to-severe ARDS in critically ill patients with COVID-19: a multicenter cohort study	28
Right dose, right now: bedside, real-time, data-driven, and personalised antibiotic dosing in critically ill patients with sepsis or septic shock—a two-centre randomised clinical trial	28
Serum uric acid, disease severity and outcomes in COVID-19	28
Establishing a critical care network in Asia to improve care for critically ill patients in low- and middle-income countries	28
Acute kidney injury in critical COVID-19: a multicenter cohort analysis in seven large hospitals in Belgium	28
The glycocalyx as a permeability barrier: basic science and clinical evidence	28
Serum renin and major adverse kidney events in critically ill patients: a multicenter prospective study	28
Clinical and biochemical endpoints and predictors of response to plasma exchange in septic shock: results from a randomized controlled trial	27
Protective reactive thymus hyperplasia in COVID-19 acute respiratory distress syndrome	27
Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study	27
Individualized resuscitation strategy for septic shock formalized by finite mixture modeling and dynamic treatment regimen	27
Vitamin C for ≥ 5 days is associated with decreased hospital mortality in sepsis subgroups: a nationwide cohort study	26
Diaphragm thickening fraction predicts noninvasive ventilation outcome: a preliminary physiological study	26
Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure: insights from the PRoVENT-COVID study	26
Impact of dexamethasone on the incidence of ventilator-associated pneumonia in mechanically ventilated COVID-19 patients: a propensity-matched cohort study	26
Venoarterial extracorporeal membrane oxygenation induces early immune alterations	26
Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature	26
Novel protocol combining physical and nutrition therapies, Intensive Goal-directed REhabilitation with Electrical muscle stimulation and Nutrition (IGREEN) care bundle	26
Cognitive phenotypes 1 month after ICU discharge in mechanically ventilated patients: a prospective observational cohort study	26
Assessing the SAfety and FEasibility of bedside portable low-field brain Magnetic Resonance Imaging in patients on ECMO (SAFE-MRI ECMO study): study protocol and first case series experience	26
Survival after extracorporeal membrane oxygenation in severe COVID-19 ARDS: results from an international multicenter registry	26
Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness	26