Apoptosis

Article	Citations
Global trends in PANoptosis research: bibliometrics and knowledge graph analysis	441
Disruption of iron homeostasis by HERC2-FTL axis leads to chondrocyte loss and exacerbates osteoarthritis	295
Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward PARP inhibitors as maintenance therapy	121
ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP	112
An integrated investigation of sulfotransferases (SULTs) in hepatocellular carcinoma and identification of the role of SULT2A1 on stemness	92
Ablation of FBXO38 triggers lysosome-dependent STING degradation to drive chemotherapy resistance in cervical cancer	67
Exosomes derived from FN14-overexpressing BMSCs activate the NF-κB signaling pathway to induce PANoptosis in osteosarcoma	66
Succinate-mediated SUCNR1 activation in tumor-associated macrophages promotes M2 polarization and cetuximab resistance in colorectal cancer: in vitro and in vivo insights	64
Transcription factor EB-mediated autophagy affects cell migration and inhibits apoptosis to promote endometriosis	64
Breast cancer: taxonomy, distribution analysis, risk factors, predictive biomarkers, and modern treatment method	61
Molecular probes for monitoring pyroptosis: design, imaging and theranostic application	58
Programmed cell death lives	58
Spatially defined danger zone shapes gastric cancer progression through CCDC80+ fibroblast–induced CD8+ T cell dysfunction	58
Higher replication potential of West Nile virus governs apoptosis induction in human neuroblastoma cells	57
N6-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m6A/PD-L1 manner	57
Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak	54
Caspase-1 in cancer and inflammatory diseases: a potential therapeutic target	54
The ATG14: multi-layer autophagy control and an emerging therapeutic target in cancer	53
LncRNA PVT1 delays skin photoaging by sequestering miR-551b-3p to release AQP3 expression via ceRNA mechanism	53
Research progress on the mechanism of FOXO protein in sepsis	53
The circTIMP2/miR-106a/TIMP2 tumor-suppressive axis versus tumor-derived exosomal counteraction in gastric cancer	52
The CXCL8-CXCR2 axis promotes M2 macrophage polarization in ovarian cancer via RASGRP4-mediated mTOR-STAT3 signaling	51
Machine learning-based analysis of programmed cell death types and key genes in intervertebral disc degeneration	49
Multiple myeloma with high expression of SLC7A11 is sensitive to erastin-induced ferroptosis	48
The STING signaling pathways and bacterial infection	47

Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury	47
Mitophagy: a novel avenue for herbal medicines alleviating myocardial ischemia/reperfusion injury	47
An immunogenic cell death-related signature predicts prognosis and immunotherapy response in stomach adenocarcinoma	46
Mitochondrial dysfunction and cellular senescence drive accelerated gestational aging in spontaneous preterm birth: a narrative review	46
Regulation of autophagy of the heart in ischemia and reperfusion	43
Dual role of endoplasmic reticulum stress-ATF-6 activation in autophagy and apoptosis induced by cyclic stretch in myoblast	42
PLAGL2-STAU1-NCOA4 axis enhances gastric cancer peritoneal metastasis by resisting ferroptosis via ferritinophagy	41
Genipin protects against acute liver injury by abrogating ferroptosis via modification of GPX4 and ALOX15-launched lipid peroxidation in mice	41
LncRNA PVT1 drives macrophage polarization and triple-negative breast cancer progression via PPARγ-mediated transcriptional activation​	40
Transcriptomic responses of cumulus granulosa cells to SARS-CoV-2 infection during controlled ovarian stimulation	40
Targeting cuproptosis in liver cancer: Molecular mechanisms and therapeutic implications	37
GSDME-dependent astrocyte pyroptosis promotes the progression of neuroinflammation in experimental cerebral malaria	37
PTGR1-mediated immune evasion mechanisms in late-stage triple-negative breast cancer: mechanisms of M2 macrophage infiltration and CD8+ T cell suppression	36
Manipulating the PANoptosome: baseless hype or a newfound hope for human immunity?	35
Elevated serum mtDNA in COVID-19 patients is linked to SARS-CoV-2 envelope protein targeting mitochondrial VDAC1, inducing apoptosis and mtDNA release	35
m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling	34
A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury	34
HMGB1 blockade attenuates cardiac injury induced by radiotherapy combined with PD-1 inhibitor while maintaining the anti-tumor efficacy	33
Correction: Targeting PNPO to suppress tumor growth via inhibiting autophagic flux and to reverse paclitaxel resistance in ovarian cancer	33
Necroptosis in myocardial ischaemia-reperfusion injury: current update on mechanisms, therapeutic targets, and translational potential	33
Rising impact of cell death research	33
Bufalin targeting BFAR inhibits the occurrence and metastasis of gastric cancer through PI3K/AKT/mTOR signal pathway	32
Neural stem cell-derived exosomal PA2G4 induces ANXA2 degradation to promote mitophagy and alleviate neuronal oxidative stress in cerebral ischemia/reperfusion	32
CD95 ligand drives abdominal aortic aneurysm progression through Caspase-8-mediated GSDMD-dependent endothelial pyroptosis: modulation by SRC kinase	32
Analysis of cuproptosis-related lncRNA signature for predicting prognosis and tumor immune microenvironment in pancreatic cancer	31
Autophagy regulation of pyroptosis and ferroptosis: a new strategy for colorectal cancer treatment	31
Endothelial SPRY1 deficiency associates with angiogenic-metabolic reprogramming in pulmonary arterial hypertension: a multi-omics analysis of bulk and single-cell transcriptomic profiles	30
Aquaporin-1 stabilizes β-catenin to promote NLRP3 inflammasome-mediated pyroptosis in rheumatoid arthritis	30
LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis	30
Single-cell profiling and machine learning identify cuproptosis-related fibroblast subpopulations and fibrogenesis modulator AEBP1 in endometriosis	30
Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons	30
The IAP family member BRUCE/BIRC6: an emerging new player in balancing life and death	29
Exploring the role of ITGB6: fibrosis, cancer, and other diseases	29
PSD3 links autophagic flux to MHC-I–associated immune modulation in esophageal squamous cell carcinoma	28
The role of the NcRNA/ferroptosis axis in lung cancer: molecular mechanisms and potential therapeutic targets	27
Integrative analysis of genes reveals endoplasmic reticulum stress-related immune responses involved in dilated cardiomyopathy with fibrosis	27
Novel dual inhibitor targeting CDC25 and HDAC for treating triple-negative breast cancer	27
Exploring a specialized programmed-cell death patterns to predict the prognosis and sensitivity of immunotherapy in cutaneous melanoma via machine learning	27
Casein kinase 1α mediates eryptosis: a review	27
Endothelial HMGB1-AIM2 axis worsens myocardial ischemia—reperfusion injury by regulating endothelial pyroptosis	27
CACNA1C-AS2 inhibits cell proliferation and suppresses cell migration and invasion via targeting FBXO45 and PI3K/AKT/mTOR pathways in glioma	27
The emerging role of cholesterol metabolism in gynecologic cancer development and therapy	27
CHI3L1 promotes myocardial fibrosis via regulating lncRNA TUG1/miR-495-3p/ETS1 axis	27
The critical role of X-linked inhibitor of apoptosis protein (XIAP) in tumor development	26
HMGB1: a multifaceted mediator of cell death pathways in cardiovascular diseases	26
Ferroptosis-centered strategies: redefining therapeutic resistance & adaptation in modern oncology	25
A ZFP42/MARK2 regulatory network reduces the damage of retinal ganglion cells in glaucoma: a study based on GEO dataset and in vitro experiments	25
DDIT3 drives nucleus pulposus cell PANoptosis and intervertebral disc degeneration progression	25
Regulated cell death: a multidimensional regulatory network in the pathogenesis of renal fibrosis	25
Metrnl in health and disease: tissue-specific actions and signaling networks	24

Axitinib promotes stemness and vasculogenic mimicry in triple-negative breast cancer by disrupting THBS1-CD47 axis-mediated endothelial-tumor cell communication	24
Heteronemin suppresses chemoresistant oral squamous cell carcinoma cells through ROS-mediated apoptosis and cuproptosis-associated mitochondrial stress	24
Zincoptosis: does it exist?	23
Harnessing cuproptosis: a new avenue for targeted cancer therapies	23
Exosome-mediated triple drug delivery enhances apoptosis in pancreatic cancer cells	23
Overview of genetic and epigenetic regulation of human papillomavirus and apoptosis in cervical cancer	23
5-Aminolevulinic acid-mediated photodynamic therapy in combination with kinase inhibitor lapatinib enhances glioblastoma cell death	23
Osteopontin-driven TGF-β1 signaling via integrin αvβ3-NF-κB axis impairs NK cell function in head and neck squamous cell carcinoma	22
Critical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury	22
Brazilin alleviates acute lung injury via inhibition of ferroptosis through the SIRT3/GPX4 pathway	22
Live-cell imaging and mathematical analysis of the “community effect” in apoptosis	22
Targeting mitochondrial apoptosis in septic lung injury: protective potential of omega-3 fatty acids	22
His-tagged pro-apoptotic peptides: enhancing cell internalization and anticancer effect in vitro	22
GLI2 confers ferroptosis resistance in bladder cancer by transcriptionally upregulating PRDX1	21
Macrophage ferroptosis in hematologic malignancies: emerging mechanisms and therapeutic implications	21
USP43 impairs cisplatin sensitivity in epithelial ovarian cancer through HDAC2-dependent regulation of Wnt/β-catenin signaling pathway	21
Anoikis in cancer: molecular mechanisms, resistance, and therapeutic strategies	21
Human umbilical cord mesenchymal stem cell-derived exosomes carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2 polarization and prevent colorectal liver metastasis	21
Cuproptosis identifies respiratory subtype of renal cancer that confers favorable prognosis	20
The N6-methyladenosine writer METTL3 promotes breast cancer progression through YTHDF2-dependent posttranscriptional silencing of GSDMD	20
Ferroptosis: a novel therapeutic warrior in the battle against leukemia	20
The role of TIGIT-CD226-PVR axis in mediating T cell exhaustion and apoptosis in NSCLC	20
PANoptosis: a potential new target for programmed cell death in breast cancer treatment and prognosis	20
Suppression of endothelial cell PANoptosis: qingyi decoction targets the TMAO-HMGB1 pathway to mitigate lung injury in acute pancreatitis rats	20
Correction to: NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis	20
Oxidative stress and ferroptosis in diabetic cardiomyopathy: mechanistic interplay and therapeutic implications	20
Combined effects of natural products and exercise on apoptosis pathways in obesity-related skeletal muscle dysfunction	19
QD394 induces ferroptosis and suppresses the proliferation of colorectal cancer via the SP1/JNK pathway	19
The GATA3-RFPL3-ASK1 axis suppresses breast cancer growth and lung metastasis	19
Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission	19
Pyroptosis as a double-edged sword in colorectal cancer: Molecular mechanisms and therapeutic opportunities	19
The regulation of necroptosis by ubiquitylation	19
EFNA4-enhanced deubiquitination of SLC7A11 inhibits ferroptosis in hepatocellular carcinoma	19
Targeted delivery of RGD-JEG-3-EVs for placental vascular regeneration in preeclampsia: from molecular mechanism toward therapy	19
Deciphering macrophage heterogeneity and factors driving M2 polarization in lung adenocarcinoma through single-cell RNA sequencing	18
MARCH5 promotes aerobic glycolysis to facilitate ovarian cancer progression via ubiquitinating MPC1	18
SFG enhances apoptosis of hepatocellular carcinoma by inhibiting tunneling nanotubes-mediated mitochondrial transport in the tumor microenvironment	18
Crosstalk of metabolic cell death pathways in colorectal cancer: implications for precision therapy	18
Is long-term administration of PLD-pegylated liposomal doxorubicin able to induce oral cancer?	18
DJ-1-mediated p62 degradation delays intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus cells	18
Bushen Jianpi Tiaoxue Decoction (BJTD) inhibits the LIF-mTOR signaling axis to regulate mitochondrial function and alleviate cyclophosphamide-induced diminished ovarian reserve	18
Stemness-related lncRNAs signature as a biologic prognostic model for head and neck squamous cell carcinoma	18
Correction to: Integrative analysis of genes reveals endoplasmic reticulum stress-related immune responses involved in dilated cardiomyopathy with fibrosis	18
SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients	18
Emerging role of PANoptosis in kidney diseases: molecular mechanisms and therapeutic opportunities	17
Role of the USP family in autophagy regulation and cancer progression	17
Role of ferroptosis in food-borne mycotoxin-induced toxicities	17
Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects	17
Ferroptosis dysregulation, mitochondrial dysfunction, and iron metabolism alterations are correlated with aggressiveness in uveal melanoma	17
Unlocking Parkinson’s disease: the role of microRNAs in regulation, diagnosis, and therapy	16
Enhancing the efficacy of VEGF inhibitors by co-inhibition of HIF in the treatment of glioblastoma	16
IGF2BP3 boosts lactate generation to accelerate gastric cancer immune evasion	16
Unveiling the hidden role of disulfidptosis in kidney renal clear cell carcinoma: a prognostic signature for personalized treatment	16
Integrating single-cell sequencing and machine learning to uncover the role of mitophagy in subtyping and prognosis of esophageal cancer	16
Ruptosis: a novel hormone-triggered cytotoxic cell death program linking endocrine homeostasis to innate immunity	16
Phillyrin promotes flap survival by mitigating pyroptosis through the TLR4/NF-κB/NLRP3 signaling pathway	16
Adenylate kinase 4 promotes radioresistance by suppressing radiation-induced ferroptosis through metabolic regulation in glioblastoma	16
TBC1D10B promotes tumor progression in colon cancer via PAK4‑mediated promotion of the PI3K/AKT/mTOR pathway	16
DDI2 promotes tumor metastasis and resists antineoplastic drugs-induced apoptosis in colorectal cancer	15
Reparative effects of VCAM-1 high-performance MSC-derived exosomes on aged diabetic cardiomyocyte injury: a focus on ferroptosis suppression	15
Pollutant-regulated mitophagy: new perspectives in environmental toxicology	15
The mechanistic study of quercetin in the treatment of alcoholic brain injury via the JNK/P38 MAPK signaling pathway	15
Prognostic implications and therapeutic opportunities related to CAF subtypes in CMS4 colorectal cancer: insights from single-cell and bulk transcriptomics	15
Beyond the hype: the glycolysis–pyroptosis axis in intervertebral disc degeneration and the path to therapeutic translation	15
DLD is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients	15
METTL3 safeguard cancer cells from programmed cell death during detachment from their surrounding extracellular matrix	15
Crosstalk between protein lipidation and ubiquitination in tumor biology	15
KRAS-mediated CCDC6 degradation drives xCT upregulation and ferroptosis evasion	14
Development and experimental validation of a machine learning-based disulfidptosis-related ferroptosis score for hepatocellular carcinoma	14
Targeting ferroptosis: a novel insight against myocardial infarction and ischemia–reperfusion injuries	14
A novel programmed cell death signature predicts clinical outcomes in clear cell renal cell carcinoma and identifies PLK1 as a therapeutic target	14
Correction: Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomalmitochondrial axis	14
Zinc regulates the balance of specific gut microbiota through MTF1/Nrf2 and mitigates ferroptosis through activation of PINK1/Parkin/mitophagy via the gut-kidney axis in sepsis-associated acute kidney	14
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis	14
GJB2 as a novel prognostic biomarker associated with immune infiltration and cuproptosis in ovarian cancer	14
Multi-omics nominates VDAC2 as a candidate protective locus in sepsis-associated cholesterol dysregulation	14
Mitochondria–membrane contact duration: a spatial checkpoint for oxidative cell death	14
A new perspective on iron-dependent cell death: PRDX-1-mediated ferroptosis in tumor cells	14
Emerging role of RNA m6A modifications in laryngeal squamous cell carcinoma: insights into tumorigenesis and therapeutic potential	14
microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin β1 recycling on the membrane	14

Novel impact of metal ion-induced cell death on diabetic cardiomyopathy pathogenesis and therapy	13
AIM2-PANoptosome-driven PANoptosis in hepatic lipid dysregulation induced by β-HCH and nanoplastics co-exposure	13
Bibliometric analysis and mini-review of global research on pyroptosis in the field of cancer	13
Bufalin inhibits immune escape in metastatic colorectal cancer by regulating M2 macrophage polarization	13
Microplastics promote chemoresistance by mediating lipid metabolism and suppressing pyroptosis in colorectal cancer	13
NUFIP1-engineered exosomes modulate propofol-induced neurotoxicity in neonatal rats via the ERS apoptotic pathway	13
Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1	13
Copper homeostasis and cuproptosis in cancer: mitochondrial metabolic dependency and nanomedicine-based therapeutic strategies	13
Research progress on the mechanism of curcumin in cerebral ischemia/reperfusion injury: a narrative review	13
Targeting BACH1 by HPPE inhibits the Wnt/β-catenin pathway and malignant phenotype in glioblastoma cells	13
Taginostat, a new quinolone-based HDAC6 inhibitor, promotes apoptosis of chronic lymphocytic leukemia cells in vitro and in vivo by activating STAT4	13
MLKL and other necroptosis-related genes promote the tumor immune cell infiltration, guiding for the administration of immunotherapy in bladder urothelial carcinoma	13
EVA1A reverses lenvatinib resistance in hepatocellular carcinoma through regulating PI3K/AKT/p53 signaling axis	13
A deadly taste: linking bitter taste receptors and apoptosis	13
Understanding the mechanistic roles of environmental heavy metal stressors in regulating ferroptosis: adding new paradigms to the links with diseases	13