OOIR: Observatory of International Research

Papers

(The TQCC of Apoptosis is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP	296
Monitoring yeast regulated cell death: trespassing the point of no return to loss of plasma membrane integrity	233
Nobiletin as an inducer of programmed cell death in cancer: a review	172
Programmed cell death lives	171
An integrated investigation of sulfotransferases (SULTs) in hepatocellular carcinoma and identification of the role of SULT2A1 on stemness	122
Exosomes derived from FN14-overexpressing BMSCs activate the NF-κB signaling pathway to induce PANoptosis in osteosarcoma	88
Transcription factor EB-mediated autophagy affects cell migration and inhibits apoptosis to promote endometriosis	75
Global trends in PANoptosis research: bibliometrics and knowledge graph analysis	49
N6-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m6A/PD-L1 manner	47
Molecular probes for monitoring pyroptosis: design, imaging and theranostic application	47
Tumor cell-derived exosome RNF126 affects the immune microenvironment and promotes nasopharyngeal carcinoma progression by regulating PTEN ubiquitination	46
Higher replication potential of West Nile virus governs apoptosis induction in human neuroblastoma cells	45
Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury	44
The CXCL8-CXCR2 axis promotes M2 macrophage polarization in ovarian cancer via RASGRP4-mediated mTOR-STAT3 signaling	44
Multiple myeloma with high expression of SLC7A11 is sensitive to erastin-induced ferroptosis	40
Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak	39
Machine learning-based analysis of programmed cell death types and key genes in intervertebral disc degeneration	39
The STING signaling pathways and bacterial infection	39
LncRNA PVT1 delays skin photoaging by sequestering miR-551b-3p to release AQP3 expression via ceRNA mechanism	37
PLAGL2-STAU1-NCOA4 axis enhances gastric cancer peritoneal metastasis by resisting ferroptosis via ferritinophagy	36
A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury	35
Transcriptomic responses of cumulus granulosa cells to SARS-CoV-2 infection during controlled ovarian stimulation	35
Necroptosis in myocardial ischaemia-reperfusion injury: current update on mechanisms, therapeutic targets, and translational potential	34
Genipin protects against acute liver injury by abrogating ferroptosis via modification of GPX4 and ALOX15-launched lipid peroxidation in mice	32
An immunogenic cell death-related signature predicts prognosis and immunotherapy response in stomach adenocarcinoma	32

Dual role of endoplasmic reticulum stress-ATF-6 activation in autophagy and apoptosis induced by cyclic stretch in myoblast	32
PTGR1-mediated immune evasion mechanisms in late-stage triple-negative breast cancer: mechanisms of M2 macrophage infiltration and CD8+ T cell suppression	32
Manipulating the PANoptosome: baseless hype or a newfound hope for human immunity?	30
Elevated serum mtDNA in COVID-19 patients is linked to SARS-CoV-2 envelope protein targeting mitochondrial VDAC1, inducing apoptosis and mtDNA release	29
Regulation of autophagy of the heart in ischemia and reperfusion	29
Rising impact of cell death research	28
m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling	28
Analysis of cuproptosis-related lncRNA signature for predicting prognosis and tumor immune microenvironment in pancreatic cancer	27
Correction: Targeting PNPO to suppress tumor growth via inhibiting autophagic flux and to reverse paclitaxel resistance in ovarian cancer	27
LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis	27
The role of lncRNA OIP5-AS1 in cancer development and progression	26
Novel dual inhibitor targeting CDC25 and HDAC for treating triple-negative breast cancer	26
Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons	26
CHI3L1 promotes myocardial fibrosis via regulating lncRNA TUG1/miR-495-3p/ETS1 axis	25
JNK-dependent phosphorylation and nuclear translocation of EGR-1 promotes cardiomyocyte apoptosis	25
A ZFP42/MARK2 regulatory network reduces the damage of retinal ganglion cells in glaucoma: a study based on GEO dataset and in vitro experiments	25
Bufalin targeting BFAR inhibits the occurrence and metastasis of gastric cancer through PI3K/AKT/mTOR signal pathway	25
Exploring the role of ITGB6: fibrosis, cancer, and other diseases	25
CACNA1C-AS2 inhibits cell proliferation and suppresses cell migration and invasion via targeting FBXO45 and PI3K/AKT/mTOR pathways in glioma	24
Integrative analysis of genes reveals endoplasmic reticulum stress-related immune responses involved in dilated cardiomyopathy with fibrosis	24
Overview of genetic and epigenetic regulation of human papillomavirus and apoptosis in cervical cancer	24
Exploring a specialized programmed-cell death patterns to predict the prognosis and sensitivity of immunotherapy in cutaneous melanoma via machine learning	24
5-Aminolevulinic acid-mediated photodynamic therapy in combination with kinase inhibitor lapatinib enhances glioblastoma cell death	23
XIAP as a multifaceted molecule in Cellular Signaling	23
LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis	23
Casein kinase 1α mediates eryptosis: a review	22
Exosome-mediated triple drug delivery enhances apoptosis in pancreatic cancer cells	22
Zincoptosis: does it exist?	22
The role of the NcRNA/ferroptosis axis in lung cancer: molecular mechanisms and potential therapeutic targets	22
The critical role of X-linked inhibitor of apoptosis protein (XIAP) in tumor development	22
The role of TIGIT-CD226-PVR axis in mediating T cell exhaustion and apoptosis in NSCLC	21
Critical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury	20
Ferroptosis: a novel therapeutic warrior in the battle against leukemia	20
Live-cell imaging and mathematical analysis of the “community effect” in apoptosis	20
The N6-methyladenosine writer METTL3 promotes breast cancer progression through YTHDF2-dependent posttranscriptional silencing of GSDMD	20
Brazilin alleviates acute lung injury via inhibition of ferroptosis through the SIRT3/GPX4 pathway	19
USP43 impairs cisplatin sensitivity in epithelial ovarian cancer through HDAC2-dependent regulation of Wnt/β-catenin signaling pathway	19
Let-7a-5p regulated by lncRNA-MEG3 promotes functional differentiation to Schwann cells from adipose derived stem cells via directly inhibiting RBPJ-mediating Notch pathway	18
MARCH5 promotes aerobic glycolysis to facilitate ovarian cancer progression via ubiquitinating MPC1	17
Combined effects of natural products and exercise on apoptosis pathways in obesity-related skeletal muscle dysfunction	17
Anticancer effect and apoptosis induction by azaflavanone derivative in human prostate cancer cells	17
PANoptosis: a potential new target for programmed cell death in breast cancer treatment and prognosis	17
Correction to: NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis	17
Human umbilical cord mesenchymal stem cell-derived exosomes carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2 polarization and prevent colorectal liver metastasis	17
Mechanisms of nucleophosmin (NPM)-mediated regulated cell death elucidated by Hsp70 during renal ischemia	16
Stemness-related lncRNAs signature as a biologic prognostic model for head and neck squamous cell carcinoma	16
Targeting mitochondria as a therapeutic anti-gastric cancer approach	16
DJ-1-mediated p62 degradation delays intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus cells	16
EFNA4-enhanced deubiquitination of SLC7A11 inhibits ferroptosis in hepatocellular carcinoma	16
The regulation of necroptosis by ubiquitylation	16

Integrating single-cell sequencing and machine learning to uncover the role of mitophagy in subtyping and prognosis of esophageal cancer	16
The mechanistic study of quercetin in the treatment of alcoholic brain injury via the JNK/P38 MAPK signaling pathway	16
Cuproptosis identifies respiratory subtype of renal cancer that confers favorable prognosis	16
Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission	16
Unveiling the hidden role of disulfidptosis in kidney renal clear cell carcinoma: a prognostic signature for personalized treatment	16
Circ_0000523 regulates miR-1184/COL1A1/PI3K/Akt pathway to promote nasopharyngeal carcinoma progression	16
Role of ferroptosis in food-borne mycotoxin-induced toxicities	15
Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects	15
Role of the USP family in autophagy regulation and cancer progression	15
TBC1D10B promotes tumor progression in colon cancer via PAK4‑mediated promotion of the PI3K/AKT/mTOR pathway	15
Correction to: Integrative analysis of genes reveals endoplasmic reticulum stress-related immune responses involved in dilated cardiomyopathy with fibrosis	15
IGF2BP3 boosts lactate generation to accelerate gastric cancer immune evasion	15
Unlocking Parkinson’s disease: the role of microRNAs in regulation, diagnosis, and therapy	15
Emerging role of PANoptosis in kidney diseases: molecular mechanisms and therapeutic opportunities	15
Bushen Jianpi Tiaoxue Decoction (BJTD) inhibits the LIF-mTOR signaling axis to regulate mitochondrial function and alleviate cyclophosphamide-induced diminished ovarian reserve	15
SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients	15
DDI2 promotes tumor metastasis and resists antineoplastic drugs-induced apoptosis in colorectal cancer	14
GJB2 as a novel prognostic biomarker associated with immune infiltration and cuproptosis in ovarian cancer	14
Prognostic implications and therapeutic opportunities related to CAF subtypes in CMS4 colorectal cancer: insights from single-cell and bulk transcriptomics	14
Is long-term administration of PLD-pegylated liposomal doxorubicin able to induce oral cancer?	14
A new perspective on iron-dependent cell death: PRDX-1-mediated ferroptosis in tumor cells	14
Benzofuran pyran hybrid prevents glucocorticoid induced osteoporosis in mice via modulation of canonical Wnt/β-catenin signaling	14
DLD is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients	14
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis	14
Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells	14
Targeting ferroptosis: a novel insight against myocardial infarction and ischemia–reperfusion injuries	13
The fundamental contribution of James Maxwell Ross Cormack (1909–1975) in suggesting the term “apoptosis”	13
Correction: Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomalmitochondrial axis	13
microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin β1 recycling on the membrane	13
Context-dependent activation of p53 target genes and induction of apoptosis by actinomycin D in aerodigestive tract cancers	13
A novel programmed cell death signature predicts clinical outcomes in clear cell renal cell carcinoma and identifies PLK1 as a therapeutic target	13
Bibliometric analysis and mini-review of global research on pyroptosis in the field of cancer	13
Understanding the mechanistic roles of environmental heavy metal stressors in regulating ferroptosis: adding new paradigms to the links with diseases	13
Development and experimental validation of a machine learning-based disulfidptosis-related ferroptosis score for hepatocellular carcinoma	13
Research progress on the mechanism of curcumin in cerebral ischemia/reperfusion injury: a narrative review	13
A deadly taste: linking bitter taste receptors and apoptosis	13
EVA1A reverses lenvatinib resistance in hepatocellular carcinoma through regulating PI3K/AKT/p53 signaling axis	13
Bufalin inhibits immune escape in metastatic colorectal cancer by regulating M2 macrophage polarization	13
MLKL and other necroptosis-related genes promote the tumor immune cell infiltration, guiding for the administration of immunotherapy in bladder urothelial carcinoma	12
Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1	12
Novel impact of metal ion-induced cell death on diabetic cardiomyopathy pathogenesis and therapy	12
The gut microbial metabolite phenylacetylglutamine increases susceptibility to atrial fibrillation after myocardial infarction through ferroptosis and NLRP3 inflammasome	12
Intravenous immunoglobulin ameliorates doxorubicin-induced intestinal mucositis by inhibiting the Syk/PI3K/Akt axis and ferroptosis	12
Necroptosis inhibitors: mechanisms of action and therapeutic potential	12
Diallyl disulfide in oncotherapy: molecular mechanisms and therapeutic potentials	12
IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD + acute myeloid leukemia	12
AIM2-PANoptosome-driven PANoptosis in hepatic lipid dysregulation induced by β-HCH and nanoplastics co-exposure	12
Targeted delivery of FAK siRNA by engineered exosomes to reverse cetuximab resistance via activating paraptosis in colon cancer	12