OOIR: Observatory of International Research

Papers

(The TQCC of Apoptosis is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP	303
Investigation of GPR143 as a promising novel marker for the progression of skin cutaneous melanoma through bioinformatic analyses and cell experiments	176
Nobiletin as an inducer of programmed cell death in cancer: a review	137
Ischemia reperfusion injury induces pyroptosis and mediates injury in steatotic liver thorough Caspase 1 activation	133
New prospects of cancer therapy based on pyroptosis and pyroptosis inducers	89
TM2, a novel semi-synthetic taxoid, exerts anti-MDR activity in NSCLC by inhibiting P-gp function and stabilizing microtubule polymerization	76
Acetic acid triggers cytochrome c release in yeast heterologously expressing human Bax	75
Exploration of microRNA-106b-5p as a therapeutic target in intervertebral disc degeneration: a preclinical study	59
Mechanisms of nucleophosmin (NPM)-mediated regulated cell death elucidated by Hsp70 during renal ischemia	55
A quarter century of Apoptosis	46
Advancing the frontiers of colorectal cancer treatment: harnessing ferroptosis regulation	45
PARP-2 mediates cardiomyocyte aging and damage induced by doxorubicin through SIRT1 Inhibition	44
mTOR deletion ameliorates CD4 + T cell apoptosis during sepsis by improving autophagosome-lysosome fusion	42
N6-methyladenosine writer METTL3 accelerates the sepsis-induced myocardial injury by regulating m6A-dependent ferroptosis	38
Metabolic Heterogeneity and Potential Immunotherapeutic Responses Revealed by Single-Cell Transcriptomics of Breast Cancer	35
C-terminal region of Rv1039c (PPE15) protein of Mycobacterium tuberculosis targets host mitochondria to induce macrophage apoptosis	33
Resveratrol suppresses liver cancer progression by downregulating AKR1C3: targeting HCC with HSA nanomaterial as a carrier to enhance therapeutic efficacy	32
The role of hydrogen sulfide regulation of ferroptosis in different diseases	30
Glutamine deprivation in glioblastoma stem cells triggers autophagic SIRT3 degradation to epigenetically restrict CD133 expression and stemness	28
Targeting PAX8 sensitizes ovarian cancer cells to ferroptosis by inhibiting glutathione synthesis	27
Global trends in PANoptosis research: bibliometrics and knowledge graph analysis	25
Pyroptosis in acute pancreatitis and its therapeutic regulation	25
An integrated investigation of sulfotransferases (SULTs) in hepatocellular carcinoma and identification of the role of SULT2A1 on stemness	25
Targeting mitochondria as a therapeutic anti-gastric cancer approach	24
Machine learning framework develops neutrophil extracellular traps model for clinical outcome and immunotherapy response in lung adenocarcinoma	23

Gamma irradiation induces a pro-apoptotic state in longer stored platelets, without progressing to an overt apoptosis by day 7 of storage	23
Enhancing or inhibiting apoptosis? The effects of ucMSC-Ex in the treatment of different degrees of traumatic pancreatitis	22
Rictor, an essential component of mTOR complex 2, undergoes caspase-mediated cleavage during apoptosis induced by multiple stimuli	22
Bufalin reverses cancer-associated fibroblast-mediated colorectal cancer metastasis by inhibiting the STAT3 signaling pathway	22
Integrated analysis reveals a novel 5-fluorouracil resistance-based prognostic signature with promising implications for predicting the efficacy of chemotherapy and immunotherapy in patients with colo	21
A novel safer CD19CAR with shRNA interference of IFN-γ can reduce multiple cytokine levels without significantly compromising its killing efficacy	21
Notch1 signaling activation alleviates coronary microvascular dysfunction through histone modification of Nrg-1 via the interaction between NICD and GCN5	20
Programmed cell death lives	20
Ambra1 in cancer: implications for clinical oncology	20
Stemness-related lncRNAs signature as a biologic prognostic model for head and neck squamous cell carcinoma	20
Study on the activation of cell death mechanisms: in search of new therapeutic targets in glioblastoma multiforme	19
AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via BadSer136 phosphorylation	19
Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells	19
Role of APR3 in cancer: apoptosis, autophagy, oxidative stress, and cancer therapy	19
Molecular probes for monitoring pyroptosis: design, imaging and theranostic application	19
Anticancer effect and apoptosis induction by azaflavanone derivative in human prostate cancer cells	19
TRIM23 promotes 5-Fluorouracil resistance in colorectal cancer by upregulating GALNT4 expression	19
miR-30b-5p inhibits cancer progression and enhances cisplatin sensitivity in lung cancer through targeting LRP8	18
Benefits of high-intensity interval training compared to continuous training to reduce apoptotic markers in female rats with cisplatin nephrotoxicity – possible modulatory role of IL-11	18
IRF-1-inhibited lncRNA XIST regulated the osteogenic differentiation via miR-450b/FBXW7 axis	18
Isolation, identification, and challenges of extracellular vesicles: emerging players in clinical applications	17
IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease	17
Identification and experimental validation of PYCARD as a crucial PANoptosis-related gene for immune response and inflammation in COPD	16
MRG15 promotes cell apoptosis through inhibition of mitophagy in hyperlipidemic acute pancreatitis	15
Transcription factor EB-mediated autophagy affects cell migration and inhibits apoptosis to promote endometriosis	15
Cuproptosis identifies respiratory subtype of renal cancer that confers favorable prognosis	15
BH3-mimetics or DNA-damaging agents in combination with RG7388 overcome p53 mutation-induced resistance to MDM2 inhibition	14
The regulation of necroptosis by ubiquitylation	14
Revealing the role of necroptosis microenvironment: FCGBP + tumor-associated macrophages drive primary liver cancer differentiation towards cHCC-CCA or iCCA	14
Up-regulation of pro-angiogenic molecules and events does not relate with an angiogenic switch in metastatic osteosarcoma cells but to cell survival features	13
Analysis and experimental validation of necroptosis-related molecular classification, immune signature and feature genes in Alzheimer’s disease	13
The cross-talk between Bax, Bcl2, caspases, and DNA damage in bystander HepG2 cells is regulated by γ-radiation dose and time of conditioned media transfer	13
Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives	13
Monitoring yeast regulated cell death: trespassing the point of no return to loss of plasma membrane integrity	13
A self-amplifying loop of TP53INP1 and P53 drives oxidative stress-induced apoptosis of bone marrow mesenchymal stem cells	12
Cancer-associated fibroblasts promote malignant phenotypes of prostate cancer cells via autophagy	12
Programmed cell death, redox imbalance, and cancer therapeutics	12
N6-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m6A/PD-L1 manner	12
Comprehensive analysis of mitochondrial dysfunction and necroptosis in intracranial aneurysms from the perspective of predictive, preventative, and personalized medicine	12
ARPC5 is transcriptionally activated by KLF4, and promotes cell migration and invasion in prostate cancer via up-regulating ADAM17	12
Inhibition of miR-130b-3p restores autophagy and attenuates intervertebral disc degeneration through mediating ATG14 and PRKAA1	12
Recent advances in the role of gasotransmitters in necroptosis	11
MARCH5 promotes aerobic glycolysis to facilitate ovarian cancer progression via ubiquitinating MPC1	11
Retraction Note to: Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca2+-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular c	11
Long non-coding RNA SNHG4 enhances RNF14 mRNA stability to promote the progression of colorectal cancer by recruiting TAF15 protein	11
EFNA4-enhanced deubiquitination of SLC7A11 inhibits ferroptosis in hepatocellular carcinoma	11
Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission	11
Exosomes derived from FN14-overexpressing BMSCs activate the NF-κB signaling pathway to induce PANoptosis in osteosarcoma	11
Combined effects of natural products and exercise on apoptosis pathways in obesity-related skeletal muscle dysfunction	11
Ferroptosis: underlying mechanisms and involvement in neurodegenerative diseases	11

Cuprotosis clusters predict prognosis and immunotherapy response in low-grade glioma	11
Integrinβ3 mediates the protective effects of soluble receptor for advanced glycation end-products during myocardial ischemia/reperfusion through AKT/STAT3 signaling pathway	10
Cuproptosis in lung cancer: therapeutic options and prognostic models	10
TNF-α and RPLP0 drive the apoptosis of endothelial cells and increase susceptibility to high-altitude pulmonary edema	10
SIRT1 regulates mitochondrial fission to alleviate high altitude hypoxia inducedcardiac dysfunction in rats via the PGC-1α-DRP1/FIS1/MFF pathway	10
High pyroptosis activity in pancreatic adenocarcinoma: poor prognosis and oxaliplatin resistance	10
Phosphodiesterase 5 inhibitor sildenafil potentiates the antitumor activity of cisplatin by ROS-mediated apoptosis: a role of deregulated glucose metabolism	10
Detection of apoptotic cells based on in situ hybridization chain reaction using specific hairpins	10
Exploratory study on the efficacy of bortezomib combining mitoxantrone or CD22-CAR T therapy targeting CD19-negative relapse after CD19-CAR T cell therapy with a simpler cell-line-based model	10
Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak	10
Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury	10
SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients	10
The unfolded protein response (UPR) pathway: the unsung hero in breast cancer management	10
DJ-1-mediated p62 degradation delays intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus cells	9
Angiotensin-(1–9) prevents angiotensin II-induced endothelial apoptosis through CNPY2/PERK pathway	9
Myeloma extracellular vesicle-derived RAGE increases inflammatory responses and myotube atrophy in multiple myeloma through activation of the TLR4/NF-κB p65 pathway	9
A novel apoptosis probe, cyclic ApoPep-1, for in vivo imaging with multimodal applications in chronic inflammatory arthritis	9
Machine learning-based analysis of programmed cell death types and key genes in intervertebral disc degeneration	9
Piperlongumine, a piper alkaloid, enhances the efficacy of doxorubicin in breast cancer: involvement of glucose import, ROS, NF-κB and lncRNAs	9
Release mechanisms of major DAMPs	9
Unveiling the hidden role of disulfidptosis in kidney renal clear cell carcinoma: a prognostic signature for personalized treatment	9
Response to the letter to the editor: Dihydroartemisinin prevents palmitate-induced β-cell apoptosis	8
Higher replication potential of West Nile virus governs apoptosis induction in human neuroblastoma cells	8
Exploring the MEN1 dependent modulation of caspase 8 and caspase 3 in human pancreatic and murine embryo fibroblast cells	8
Fas ligand intracellular signaling: does PSTPIP mediate T cell death?	8
FAM83B regulates mitochondrial metabolism and anti-apoptotic activity in pulmonary adenocarcinoma	8
Targeting PNPO to suppress tumor growth via inhibiting autophagic flux and to reverse paclitaxel resistance in ovarian cancer	8
Escaping cell death via TRAIL decoy receptors: a systematic review of their roles and expressions in colorectal cancer	8
Forcing dividing cancer cells to die; low‐dose drug combinations to prevent spindle pole clustering	8
Emerging role of PANoptosis in kidney diseases: molecular mechanisms and therapeutic opportunities	8