OOIR: Observatory of International Research

Papers

(The TQCC of Apoptosis is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Release mechanisms of major DAMPs	276
BCL-2 protein family: attractive targets for cancer therapy	135
Mechanism of interaction between autophagy and apoptosis in cancer	127
Programmed cell death detection methods: a systematic review and a categorical comparison	103
Terpenoids’ anti-cancer effects: focus on autophagy	79
Mechanisms of cancer cell death induction by paclitaxel: an updated review	76
Apoptosis in Alzheimer’s disease: insight into the signaling pathways and therapeutic avenues	61
Targeting of cancer cell death mechanisms by resveratrol: a review	59
The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases	46
Ca2+ overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells	45
Regulation of autophagy of the heart in ischemia and reperfusion	40
Programmed cell death, redox imbalance, and cancer therapeutics	39
COVID-19 disrupts spermatogenesis through the oxidative stress pathway following induction of apoptosis	38
Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death	36
New insights into targeting mitochondria in ischemic injury	36
Progesterone induces apoptosis by activation of caspase-8 and calcitriol via activation of caspase-9 pathways in ovarian and endometrial cancer cells in vitro	35
FTO inhibits UPRmt-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes	33
COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus	30
Nobiletin as an inducer of programmed cell death in cancer: a review	30
Pyroptosis in acute pancreatitis and its therapeutic regulation	28
XIAP as a multifaceted molecule in Cellular Signaling	27
Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation	27
The regulation of necroptosis and perspectives for the development of new drugs preventing ischemic/reperfusion of cardiac injury	25
DNA damage induces STING mediated IL-6-STAT3 survival pathway in triple-negative breast cancer cells and decreased survival of breast cancer patients	25
m6A writer WTAP targets NRF2 to accelerate bladder cancer malignancy via m6A-dependent ferroptosis regulation	25

Apoptosis induced by SARS-CoV-2: can we target it?	24
Intracellular leucine-rich alpha-2-glycoprotein-1 competes with Apaf-1 for binding cytochrome c in protecting MCF-7 breast cancer cells from apoptosis	24
The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD+ redox state	23
Ischemia reperfusion injury induces pyroptosis and mediates injury in steatotic liver thorough Caspase 1 activation	23
Heat shock proteins-driven stress granule dynamics: yet another avenue for cell survival	23
N6-methyladenosine writer METTL3 accelerates the sepsis-induced myocardial injury by regulating m6A-dependent ferroptosis	22
miR-30b-5p inhibits cancer progression and enhances cisplatin sensitivity in lung cancer through targeting LRP8	21
Human umbilical cord mesenchymal stem cell-derived exosomes carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2 polarization and prevent colorectal liver metastasis	21
Understanding the mechanistic roles of environmental heavy metal stressors in regulating ferroptosis: adding new paradigms to the links with diseases	21
Cuproptosis identifies respiratory subtype of renal cancer that confers favorable prognosis	20
Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects	20
Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated interverte	20
Apoptotic proteins with non-apoptotic activity: expression and function in cancer	19
Pyroptosis, a target for cancer treatment?	19
LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis	19
Role of apoptosis repressor with caspase recruitment domain (ARC) in cell death and cardiovascular disease	19
p53 m6A modulation sensitizes hepatocellular carcinoma to apatinib through apoptosis	19
Crosstalk of ferroptosis regulators and tumor immunity in pancreatic adenocarcinoma: novel perspective to mRNA vaccines and personalized immunotherapy	18
The role of lncRNA OIP5-AS1 in cancer development and progression	18
Casein kinase 1α mediates eryptosis: a review	18
Targeting ferroptosis: a novel insight against myocardial infarction and ischemia–reperfusion injuries	18
Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis	18
Targeting lipid metabolism for ferroptotic cancer therapy	17
Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells	17
Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1	16
LncRNA FGD5-AS1 promotes the malignant phenotypes of ovarian cancer cells via targeting miR-142-5p	16
Improved antitumor immunity of chemotherapy in OSCC treatment by Gasdermin-E mediated pyroptosis	15
Adipose mesenchymal stem cells-derived exosomes alleviate osteoarthritis by transporting microRNA -376c-3p and targeting the WNT-beta-catenin signaling axis	15
Ambra1 regulates apoptosis and chemosensitivity in breast cancer cells through the Akt-FoxO1-Bim pathway	15
Tumor cell-derived exosome RNF126 affects the immune microenvironment and promotes nasopharyngeal carcinoma progression by regulating PTEN ubiquitination	14
Molecular mechanisms of cell death in bronchopulmonary dysplasia	14
High glucose-induced ROS-accumulation in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis	13
Triclosan induces apoptosis in Burkitt lymphoma-derived BJAB cells through caspase and JNK/MAPK pathways	13
The delay in cell death caused by the induction of autophagy by P2Et extract is essential for the generation of immunogenic signals in melanoma cells	13
FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated redox homeostasis	13
The interplay between apoptosis and ferroptosis mediated by ER stress	13
LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis	13
Dysfunctions, molecular mechanisms, and therapeutic strategies of pancreatic β-cells in diabetes	13
The role of the DFF40/CAD endonuclease in genomic stability	12
H2S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434	12
Inhibition of miR-130b-3p restores autophagy and attenuates intervertebral disc degeneration through mediating ATG14 and PRKAA1	12
Regulation of autophagy as a therapeutic option in glioblastoma	12
The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells	12
Bufalin targeting BFAR inhibits the occurrence and metastasis of gastric cancer through PI3K/AKT/mTOR signal pathway	12
mTOR deletion ameliorates CD4 + T cell apoptosis during sepsis by improving autophagosome-lysosome fusion	12
Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3/SLC7A11 axis	11
N6-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m6A/PD-L1 manner	11
microRNA-944 inhibits breast cancer cell proliferation and promotes cell apoptosis by reducing SPP1 through inactivating the PI3K/Akt pathway	11
Benzofuran pyran hybrid prevents glucocorticoid induced osteoporosis in mice via modulation of canonical Wnt/β-catenin signaling	11
Targeting mitochondria as a therapeutic anti-gastric cancer approach	11

CACNA1C-AS2 inhibits cell proliferation and suppresses cell migration and invasion via targeting FBXO45 and PI3K/AKT/mTOR pathways in glioma	11
Piperlongumine, a piper alkaloid, enhances the efficacy of doxorubicin in breast cancer: involvement of glucose import, ROS, NF-κB and lncRNAs	11
Programmed cell death lives	11
The regulation of necroptosis by ubiquitylation	10
Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway	10
SARS-CoV-2 envelope protein induces necroptosis and mediates inflammatory response in lung and colon cells through receptor interacting protein kinase 1	10
Anti-apoptosis effect of traditional Chinese medicine in the treatment of cerebral ischemia–reperfusion injury	10
Phosphodiesterase 5 inhibitor sildenafil potentiates the antitumor activity of cisplatin by ROS-mediated apoptosis: a role of deregulated glucose metabolism	10
Regulation of alveolar macrophage death in pulmonary fibrosis: a review	10
Hypobaric hypoxia triggers pyroptosis in the retina via NLRP3 inflammasome activation	10
c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia	10
Comprehensive analysis of mitochondrial dysfunction and necroptosis in intracranial aneurysms from the perspective of predictive, preventative, and personalized medicine	10
High-dose copper activates p53-independent apoptosis through the induction of nucleolar stress in human cell lines	10
Role of C-terminal domain of Mycobacterium tuberculosis PE6 (Rv0335c) protein in host mitochondrial stress and macrophage apoptosis	10
NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer	10
Circ_0000523 regulates miR-1184/COL1A1/PI3K/Akt pathway to promote nasopharyngeal carcinoma progression	10
Phloretin induces G2/M arrest and apoptosis by suppressing the β-catenin signaling pathway in colorectal carcinoma cells	9
Apoptosis and eryptosis: similarities and differences	9
Neutrophil extracellular traps mediate TLR9/Merlin axis to resist ferroptosis and promote triple negative breast cancer progression	9
Triptolide induces PANoptosis in macrophages and causes organ injury in mice	9
MicroRNA-136-5p protects cardiomyocytes from coronary microembolization through the inhibition of pyroptosis	9
Cuproptosis-related LncRNA signatures as a prognostic model for head and neck squamous cell carcinoma	9
Vitamin D3 affects browning of white adipocytes by regulating autophagy via PI3K/Akt/mTOR/p53 signaling in vitro and in vivo	9
JNK-dependent phosphorylation and nuclear translocation of EGR-1 promotes cardiomyocyte apoptosis	9
Escaping cell death via TRAIL decoy receptors: a systematic review of their roles and expressions in colorectal cancer	9