OOIR: Observatory of International Research

Papers

(The TQCC of Apoptosis is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Programmed cell death lives	248
Molecular probes for monitoring pyroptosis: design, imaging and theranostic application	186
Transcription factor EB-mediated autophagy affects cell migration and inhibits apoptosis to promote endometriosis	159
An integrated investigation of sulfotransferases (SULTs) in hepatocellular carcinoma and identification of the role of SULT2A1 on stemness	129
ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP	110
Global trends in PANoptosis research: bibliometrics and knowledge graph analysis	109
Exosomes derived from FN14-overexpressing BMSCs activate the NF-κB signaling pathway to induce PANoptosis in osteosarcoma	75
Nobiletin as an inducer of programmed cell death in cancer: a review	72
Programmed cell death, redox imbalance, and cancer therapeutics	48
N6-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m6A/PD-L1 manner	44
Monitoring yeast regulated cell death: trespassing the point of no return to loss of plasma membrane integrity	43
Machine learning-based analysis of programmed cell death types and key genes in intervertebral disc degeneration	40
LncRNA PVT1 delays skin photoaging by sequestering miR-551b-3p to release AQP3 expression via ceRNA mechanism	39
Tumor cell-derived exosome RNF126 affects the immune microenvironment and promotes nasopharyngeal carcinoma progression by regulating PTEN ubiquitination	39
Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury	37
Multiple myeloma with high expression of SLC7A11 is sensitive to erastin-induced ferroptosis	36
Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak	35
Higher replication potential of West Nile virus governs apoptosis induction in human neuroblastoma cells	35
PTGR1-mediated immune evasion mechanisms in late-stage triple-negative breast cancer: mechanisms of M2 macrophage infiltration and CD8+ T cell suppression	34
The STING signaling pathways and bacterial infection	34
PLAGL2-STAU1-NCOA4 axis enhances gastric cancer peritoneal metastasis by resisting ferroptosis via ferritinophagy	33
m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling	33
An immunogenic cell death-related signature predicts prognosis and immunotherapy response in stomach adenocarcinoma	32
Regulation of autophagy of the heart in ischemia and reperfusion	32
Elevated serum mtDNA in COVID-19 patients is linked to SARS-CoV-2 envelope protein targeting mitochondrial VDAC1, inducing apoptosis and mtDNA release	32

Genipin protects against acute liver injury by abrogating ferroptosis via modification of GPX4 and ALOX15-launched lipid peroxidation in mice	31
Necroptosis in myocardial ischaemia-reperfusion injury: current update on mechanisms, therapeutic targets, and translational potential	29
Transcriptomic responses of cumulus granulosa cells to SARS-CoV-2 infection during controlled ovarian stimulation	29
Dual role of endoplasmic reticulum stress-ATF-6 activation in autophagy and apoptosis induced by cyclic stretch in myoblast	28
A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury	26
Novel dual inhibitor targeting CDC25 and HDAC for treating triple-negative breast cancer	25
Rising impact of cell death research	25
JNK-dependent phosphorylation and nuclear translocation of EGR-1 promotes cardiomyocyte apoptosis	25
Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons	25
Exploring the role of ITGB6: fibrosis, cancer, and other diseases	24
Bufalin targeting BFAR inhibits the occurrence and metastasis of gastric cancer through PI3K/AKT/mTOR signal pathway	24
Correction: Targeting PNPO to suppress tumor growth via inhibiting autophagic flux and to reverse paclitaxel resistance in ovarian cancer	24
The role of lncRNA OIP5-AS1 in cancer development and progression	23
Analysis of cuproptosis-related lncRNA signature for predicting prognosis and tumor immune microenvironment in pancreatic cancer	23
LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis	23
5-Aminolevulinic acid-mediated photodynamic therapy in combination with kinase inhibitor lapatinib enhances glioblastoma cell death	21
CACNA1C-AS2 inhibits cell proliferation and suppresses cell migration and invasion via targeting FBXO45 and PI3K/AKT/mTOR pathways in glioma	21
Integrative analysis of genes reveals endoplasmic reticulum stress-related immune responses involved in dilated cardiomyopathy with fibrosis	21
A ZFP42/MARK2 regulatory network reduces the damage of retinal ganglion cells in glaucoma: a study based on GEO dataset and in vitro experiments	21
CHI3L1 promotes myocardial fibrosis via regulating lncRNA TUG1/miR-495-3p/ETS1 axis	20
LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis	20
XIAP as a multifaceted molecule in Cellular Signaling	20
Casein kinase 1α mediates eryptosis: a review	20
Zincoptosis: does it exist?	20
Exploring a specialized programmed-cell death patterns to predict the prognosis and sensitivity of immunotherapy in cutaneous melanoma via machine learning	20
The critical role of X-linked inhibitor of apoptosis protein (XIAP) in tumor development	20
Overview of genetic and epigenetic regulation of human papillomavirus and apoptosis in cervical cancer	19
Live-cell imaging and mathematical analysis of the “community effect” in apoptosis	19
The N6-methyladenosine writer METTL3 promotes breast cancer progression through YTHDF2-dependent posttranscriptional silencing of GSDMD	19
The role of TIGIT-CD226-PVR axis in mediating T cell exhaustion and apoptosis in NSCLC	19
Brazilin alleviates acute lung injury via inhibition of ferroptosis through the SIRT3/GPX4 pathway	18
PANoptosis: a potential new target for programmed cell death in breast cancer treatment and prognosis	18
Let-7a-5p regulated by lncRNA-MEG3 promotes functional differentiation to Schwann cells from adipose derived stem cells via directly inhibiting RBPJ-mediating Notch pathway	18
Human umbilical cord mesenchymal stem cell-derived exosomes carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2 polarization and prevent colorectal liver metastasis	18
Critical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury	18
Correction to: NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis	17
Combined effects of natural products and exercise on apoptosis pathways in obesity-related skeletal muscle dysfunction	17
MARCH5 promotes aerobic glycolysis to facilitate ovarian cancer progression via ubiquitinating MPC1	17
USP43 impairs cisplatin sensitivity in epithelial ovarian cancer through HDAC2-dependent regulation of Wnt/β-catenin signaling pathway	17
Anticancer effect and apoptosis induction by azaflavanone derivative in human prostate cancer cells	16
Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission	16
Mechanisms of nucleophosmin (NPM)-mediated regulated cell death elucidated by Hsp70 during renal ischemia	16
The regulation of necroptosis by ubiquitylation	16
Targeting mitochondria as a therapeutic anti-gastric cancer approach	16
Role of ferroptosis in food-borne mycotoxin-induced toxicities	15
Cuproptosis identifies respiratory subtype of renal cancer that confers favorable prognosis	15
Role of the USP family in autophagy regulation and cancer progression	15
Stemness-related lncRNAs signature as a biologic prognostic model for head and neck squamous cell carcinoma	15
Circ_0000523 regulates miR-1184/COL1A1/PI3K/Akt pathway to promote nasopharyngeal carcinoma progression	15
Bushen Jianpi Tiaoxue Decoction (BJTD) inhibits the LIF-mTOR signaling axis to regulate mitochondrial function and alleviate cyclophosphamide-induced diminished ovarian reserve	15

EFNA4-enhanced deubiquitination of SLC7A11 inhibits ferroptosis in hepatocellular carcinoma	15
SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients	14
Unveiling the hidden role of disulfidptosis in kidney renal clear cell carcinoma: a prognostic signature for personalized treatment	14
IGF2BP3 boosts lactate generation to accelerate gastric cancer immune evasion	14
Correction to: Integrative analysis of genes reveals endoplasmic reticulum stress-related immune responses involved in dilated cardiomyopathy with fibrosis	14
Is long-term administration of PLD-pegylated liposomal doxorubicin able to induce oral cancer?	14
Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects	14
Integrating single-cell sequencing and machine learning to uncover the role of mitophagy in subtyping and prognosis of esophageal cancer	14
TBC1D10B promotes tumor progression in colon cancer via PAK4‑mediated promotion of the PI3K/AKT/mTOR pathway	14
Terpenoids’ anti-cancer effects: focus on autophagy	13
DLD is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients	13
Development and experimental validation of a machine learning-based disulfidptosis-related ferroptosis score for hepatocellular carcinoma	13
COVID-19 disrupts spermatogenesis through the oxidative stress pathway following induction of apoptosis	13
A deadly taste: linking bitter taste receptors and apoptosis	13
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis	13
Targeting ferroptosis: a novel insight against myocardial infarction and ischemia–reperfusion injuries	13
Benzofuran pyran hybrid prevents glucocorticoid induced osteoporosis in mice via modulation of canonical Wnt/β-catenin signaling	13
Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells	13
DJ-1-mediated p62 degradation delays intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus cells	13
DDI2 promotes tumor metastasis and resists antineoplastic drugs-induced apoptosis in colorectal cancer	13
Prognostic implications and therapeutic opportunities related to CAF subtypes in CMS4 colorectal cancer: insights from single-cell and bulk transcriptomics	13
Emerging role of PANoptosis in kidney diseases: molecular mechanisms and therapeutic opportunities	13
Bufalin inhibits immune escape in metastatic colorectal cancer by regulating M2 macrophage polarization	12
Bibliometric analysis and mini-review of global research on pyroptosis in the field of cancer	12
Context-dependent activation of p53 target genes and induction of apoptosis by actinomycin D in aerodigestive tract cancers	12
EVA1A reverses lenvatinib resistance in hepatocellular carcinoma through regulating PI3K/AKT/p53 signaling axis	12
microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin β1 recycling on the membrane	12
Understanding the mechanistic roles of environmental heavy metal stressors in regulating ferroptosis: adding new paradigms to the links with diseases	12
The fundamental contribution of James Maxwell Ross Cormack (1909–1975) in suggesting the term “apoptosis”	12
Research progress on the mechanism of curcumin in cerebral ischemia/reperfusion injury: a narrative review	12
Correction: Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomalmitochondrial axis	11
IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD + acute myeloid leukemia	11
Novel impact of metal ion-induced cell death on diabetic cardiomyopathy pathogenesis and therapy	11
Necroptosis inhibitors: mechanisms of action and therapeutic potential	11
The gut microbial metabolite phenylacetylglutamine increases susceptibility to atrial fibrillation after myocardial infarction through ferroptosis and NLRP3 inflammasome	11
Intravenous immunoglobulin ameliorates doxorubicin-induced intestinal mucositis by inhibiting the Syk/PI3K/Akt axis and ferroptosis	11
A novel 8-hydroxyquinoline derivative induces breast cancer cell death through paraptosis and apoptosis	11
MLKL and other necroptosis-related genes promote the tumor immune cell infiltration, guiding for the administration of immunotherapy in bladder urothelial carcinoma	11
Mild hypothermia alleviates oxygen−glucose deprivation/reperfusion-induced apoptosis by inhibiting ROS generation, improving mitochondrial dysfunction and regulating DNA damage repair pathway in PC12	11
Targeted delivery of FAK siRNA by engineered exosomes to reverse cetuximab resistance via activating paraptosis in colon cancer	11
Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1	11