Apoptosis

Article	Citations
Release mechanisms of major DAMPs	276
BCL-2 protein family: attractive targets for cancer therapy	135
Mechanism of interaction between autophagy and apoptosis in cancer	127
Programmed cell death detection methods: a systematic review and a categorical comparison	103
Terpenoids’ anti-cancer effects: focus on autophagy	79
Mechanisms of cancer cell death induction by paclitaxel: an updated review	76
Apoptosis in Alzheimer’s disease: insight into the signaling pathways and therapeutic avenues	61
Targeting of cancer cell death mechanisms by resveratrol: a review	59
The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases	46
Ca2+ overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells	45
Regulation of autophagy of the heart in ischemia and reperfusion	40
Programmed cell death, redox imbalance, and cancer therapeutics	39
COVID-19 disrupts spermatogenesis through the oxidative stress pathway following induction of apoptosis	38
New insights into targeting mitochondria in ischemic injury	36
Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death	36
Progesterone induces apoptosis by activation of caspase-8 and calcitriol via activation of caspase-9 pathways in ovarian and endometrial cancer cells in vitro	35
FTO inhibits UPRmt-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes	33
COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus	30
Nobiletin as an inducer of programmed cell death in cancer: a review	30
Pyroptosis in acute pancreatitis and its therapeutic regulation	28
XIAP as a multifaceted molecule in Cellular Signaling	27
Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation	27
The regulation of necroptosis and perspectives for the development of new drugs preventing ischemic/reperfusion of cardiac injury	25
DNA damage induces STING mediated IL-6-STAT3 survival pathway in triple-negative breast cancer cells and decreased survival of breast cancer patients	25
m6A writer WTAP targets NRF2 to accelerate bladder cancer malignancy via m6A-dependent ferroptosis regulation	25

Apoptosis induced by SARS-CoV-2: can we target it?	24
Intracellular leucine-rich alpha-2-glycoprotein-1 competes with Apaf-1 for binding cytochrome c in protecting MCF-7 breast cancer cells from apoptosis	24
The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD+ redox state	23
Ischemia reperfusion injury induces pyroptosis and mediates injury in steatotic liver thorough Caspase 1 activation	23
Heat shock proteins-driven stress granule dynamics: yet another avenue for cell survival	23
N6-methyladenosine writer METTL3 accelerates the sepsis-induced myocardial injury by regulating m6A-dependent ferroptosis	22
miR-30b-5p inhibits cancer progression and enhances cisplatin sensitivity in lung cancer through targeting LRP8	21
Human umbilical cord mesenchymal stem cell-derived exosomes carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2 polarization and prevent colorectal liver metastasis	21
Understanding the mechanistic roles of environmental heavy metal stressors in regulating ferroptosis: adding new paradigms to the links with diseases	21
Cuproptosis identifies respiratory subtype of renal cancer that confers favorable prognosis	20
Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects	20
Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated interverte	20
Apoptotic proteins with non-apoptotic activity: expression and function in cancer	19
Pyroptosis, a target for cancer treatment?	19
LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis	19
Role of apoptosis repressor with caspase recruitment domain (ARC) in cell death and cardiovascular disease	19
p53 m6A modulation sensitizes hepatocellular carcinoma to apatinib through apoptosis	19
Casein kinase 1α mediates eryptosis: a review	18
Targeting ferroptosis: a novel insight against myocardial infarction and ischemia–reperfusion injuries	18
Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis	18
Crosstalk of ferroptosis regulators and tumor immunity in pancreatic adenocarcinoma: novel perspective to mRNA vaccines and personalized immunotherapy	18
The role of lncRNA OIP5-AS1 in cancer development and progression	18
Targeting lipid metabolism for ferroptotic cancer therapy	17
Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells	17
Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1	16
LncRNA FGD5-AS1 promotes the malignant phenotypes of ovarian cancer cells via targeting miR-142-5p	16
Improved antitumor immunity of chemotherapy in OSCC treatment by Gasdermin-E mediated pyroptosis	15
Adipose mesenchymal stem cells-derived exosomes alleviate osteoarthritis by transporting microRNA -376c-3p and targeting the WNT-beta-catenin signaling axis	15
Ambra1 regulates apoptosis and chemosensitivity in breast cancer cells through the Akt-FoxO1-Bim pathway	15
Tumor cell-derived exosome RNF126 affects the immune microenvironment and promotes nasopharyngeal carcinoma progression by regulating PTEN ubiquitination	14
Molecular mechanisms of cell death in bronchopulmonary dysplasia	14
High glucose-induced ROS-accumulation in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis	13
Triclosan induces apoptosis in Burkitt lymphoma-derived BJAB cells through caspase and JNK/MAPK pathways	13
The delay in cell death caused by the induction of autophagy by P2Et extract is essential for the generation of immunogenic signals in melanoma cells	13
FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated redox homeostasis	13
The interplay between apoptosis and ferroptosis mediated by ER stress	13
LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis	13
Dysfunctions, molecular mechanisms, and therapeutic strategies of pancreatic β-cells in diabetes	13
The role of the DFF40/CAD endonuclease in genomic stability	12
H2S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434	12
Inhibition of miR-130b-3p restores autophagy and attenuates intervertebral disc degeneration through mediating ATG14 and PRKAA1	12
Regulation of autophagy as a therapeutic option in glioblastoma	12
The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells	12
Bufalin targeting BFAR inhibits the occurrence and metastasis of gastric cancer through PI3K/AKT/mTOR signal pathway	12
mTOR deletion ameliorates CD4 + T cell apoptosis during sepsis by improving autophagosome-lysosome fusion	12
N6-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m6A/PD-L1 manner	11
microRNA-944 inhibits breast cancer cell proliferation and promotes cell apoptosis by reducing SPP1 through inactivating the PI3K/Akt pathway	11
Benzofuran pyran hybrid prevents glucocorticoid induced osteoporosis in mice via modulation of canonical Wnt/β-catenin signaling	11
Targeting mitochondria as a therapeutic anti-gastric cancer approach	11
CACNA1C-AS2 inhibits cell proliferation and suppresses cell migration and invasion via targeting FBXO45 and PI3K/AKT/mTOR pathways in glioma	11

Piperlongumine, a piper alkaloid, enhances the efficacy of doxorubicin in breast cancer: involvement of glucose import, ROS, NF-κB and lncRNAs	11
Programmed cell death lives	11
Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3/SLC7A11 axis	11
SARS-CoV-2 envelope protein induces necroptosis and mediates inflammatory response in lung and colon cells through receptor interacting protein kinase 1	10
Regulation of alveolar macrophage death in pulmonary fibrosis: a review	10
Anti-apoptosis effect of traditional Chinese medicine in the treatment of cerebral ischemia–reperfusion injury	10
Phosphodiesterase 5 inhibitor sildenafil potentiates the antitumor activity of cisplatin by ROS-mediated apoptosis: a role of deregulated glucose metabolism	10
Hypobaric hypoxia triggers pyroptosis in the retina via NLRP3 inflammasome activation	10
High-dose copper activates p53-independent apoptosis through the induction of nucleolar stress in human cell lines	10
c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia	10
Comprehensive analysis of mitochondrial dysfunction and necroptosis in intracranial aneurysms from the perspective of predictive, preventative, and personalized  medicine	10
Role of C-terminal domain of Mycobacterium tuberculosis PE6 (Rv0335c) protein in host mitochondrial stress and macrophage apoptosis	10
NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer	10
Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway	10
Circ_0000523 regulates miR-1184/COL1A1/PI3K/Akt pathway to promote nasopharyngeal carcinoma progression	10
The regulation of necroptosis by ubiquitylation	10
Triptolide induces PANoptosis in macrophages and causes organ injury in mice	9
MicroRNA-136-5p protects cardiomyocytes from coronary microembolization through the inhibition of pyroptosis	9
Cuproptosis-related LncRNA signatures as a prognostic model for head and neck squamous cell carcinoma	9
Vitamin D3 affects browning of white adipocytes by regulating autophagy via PI3K/Akt/mTOR/p53 signaling in vitro and in vivo	9
JNK-dependent phosphorylation and nuclear translocation of EGR-1 promotes cardiomyocyte apoptosis	9
Escaping cell death via TRAIL decoy receptors: a systematic review of their roles and expressions in colorectal cancer	9
Phloretin induces G2/M arrest and apoptosis by suppressing the β-catenin signaling pathway in colorectal carcinoma cells	9
Apoptosis and eryptosis: similarities and differences	9
Neutrophil extracellular traps mediate TLR9/Merlin axis to resist ferroptosis and promote triple negative breast cancer progression	9
Obstructive sleep apnea-increased DEC1 regulates systemic inflammation and oxidative stress that promotes development of pulmonary arterial hypertension	8
A novel 8-hydroxyquinoline derivative induces breast cancer cell death through paraptosis and apoptosis	8
WNT signaling modulates chemoresistance to temozolomide in p53-mutant glioblastoma multiforme	8
The histone deacetylase SIRT6 promotes glycolysis through the HIF-1α/HK2 signaling axis and induces erlotinib resistance in non-small cell lung cancer	8
Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure	8
The functions of lncRNAs in the HPV-negative cervical cancer compared with HPV-positive cervical cancer	8
ML323, a USP1 inhibitor triggers cell cycle arrest, apoptosis and autophagy in esophageal squamous cell carcinoma cells	8
Role of Escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin	8
Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis	8
TFAM-Mediated mitochondrial transfer of MSCs improved the permeability barrier in sepsis-associated acute lung injury	8
Ferroptosis: underlying mechanisms and involvement in neurodegenerative diseases	8
The deubiquitinase Usp27x as a novel regulator of cFLIPL protein expression and sensitizer to death-receptor-induced apoptosis	7
IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD + acute myeloid leukemia	7
The natural product dehydrocurvularin induces apoptosis of gastric cancer cells by activating PARP-1 and caspase-3	7
Genipin protects against acute liver injury by abrogating ferroptosis via modification of GPX4 and ALOX15-launched lipid peroxidation in mice	7
Acetylcholine exerts cytoprotection against hypoxia/reoxygenation-induced apoptosis, autophagy and mitochondrial impairment through both muscarinic and nicotinic receptors	7
Exploring the MEN1 dependent modulation of caspase 8 and caspase 3 in human pancreatic and murine embryo fibroblast cells	7
Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives	7
Mild hypothermia alleviates oxygen−glucose deprivation/reperfusion-induced apoptosis by inhibiting ROS generation, improving mitochondrial dysfunction and regulating DNA damage repair pathway in PC12	7
Hypoxic condition induced H3K27me3 modification of the LncRNA Tmem235 promoter thus supporting apoptosis of BMSCs	7
MEG3 alleviates ankylosing spondylitis by suppressing osteogenic differentiation of mesenchymal stem cells through regulating microRNA-125a-5p-mediated TNFAIP3	7
mTOR pathway mediates endoplasmic reticulum stress-induced CD4+ T cell apoptosis in septic mice	7
DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis	7
Acetic acid triggers cytochrome c release in yeast heterologously expressing human Bax	7
Up-regulation of pro-angiogenic molecules and events does not relate with an angiogenic switch in metastatic osteosarcoma cells but to cell survival features	7
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration	7
Ferroptosis and cuproptposis in kidney Diseases: dysfunction of cell metabolism	7
m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling	7
Development and experimental validation of a machine learning-based disulfidptosis-related ferroptosis score for hepatocellular carcinoma	7
Long non-coding RNA SNHG4 enhances RNF14 mRNA stability to promote the progression of colorectal cancer by recruiting TAF15 protein	7
Cancer-associated fibroblasts promote malignant phenotypes of prostate cancer cells via autophagy	7
The cross-talk between Bax, Bcl2, caspases, and DNA damage in bystander HepG2 cells is regulated by γ-radiation dose and time of conditioned media transfer	7
Targeting lysophosphatidic acid receptor with Ki16425 impedes T cell lymphoma progression through apoptosis induction, glycolysis inhibition, and activation of antitumor immune response	6
Endoplasmic reticulum stress in diabetic kidney disease: adaptation and apoptosis after three UPR pathways	6
An immunogenic cell death-related signature predicts prognosis and immunotherapy response in stomach adenocarcinoma	6
CXCR4 enhances the inhibitory effects of bone mesenchymal stem cells on lung cell apoptosis in a rat model of smoking-induced COPD	6
Long-circulating XTEN864-annexin A5 fusion protein for phosphatidylserine-related therapeutic applications	6
Research progress on the mechanism of curcumin in cerebral ischemia/reperfusion injury: a narrative review	6
Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury	6
Let-7a-5p regulated by lncRNA-MEG3 promotes functional differentiation to Schwann cells from adipose derived stem cells via directly inhibiting RBPJ-mediating Notch pathway	6
Apoptolysis: a less understood concept in the pathogenesis of Pemphigus Vulgaris	6
Fluorizoline-induced apoptosis requires prohibitins in nematodes and human cells	6
Analysis of cuproptosis-related lncRNA signature for predicting prognosis and tumor immune microenvironment in pancreatic cancer	6
Integrinβ3 mediates the protective effects of soluble receptor for advanced glycation end-products during myocardial ischemia/reperfusion through AKT/STAT3 signaling pathway	6
From ferroptosis to cuproptosis, and calcicoptosis, to find more novel metals-mediated distinct form of regulated cell death	6
PANoptosis subtypes predict prognosis and immune efficacy in gastric cancer	5
The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action	5
Pyroptosis in bone loss	5
Monitoring yeast regulated cell death: trespassing the point of no return to loss of plasma membrane integrity	5
New prospects of cancer therapy based on pyroptosis and pyroptosis inducers	5
Tumor-suppressive E3 ubiquitin ligase CHIP inhibits the PBK/ERK axis to repress stem cell properties and radioresistance in non-small cell lung cancer	5
The interplay of miRNAs and ferroptosis in diseases related to iron overload	5
Identification of ferroptosis-related signature with potential implications in prognosis and immunotherapy of renal cell carcinoma	5
Stemness-related lncRNAs signature as a biologic prognostic model for head and neck squamous cell carcinoma	5
PANoptosis: a potential new target for programmed cell death in breast cancer treatment and prognosis	5

The intricate relationship between autoimmunity disease and neutrophils death patterns: a love-hate story	5
A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury	5
GAS6/Axl is associated with AMPK activation and attenuates H2O2-induced oxidative stress	5
Benefits of high-intensity interval training compared to continuous training to reduce apoptotic markers in female rats with cisplatin nephrotoxicity – possible modulatory role of IL-11	5
Forcing dividing cancer cells to die; low‐dose drug combinations to prevent spindle pole clustering	4
Necroptosis inhibitors: mechanisms of action and therapeutic potential	4
Gamma irradiation induces a pro-apoptotic state in longer stored platelets, without progressing to an overt apoptosis by day 7 of storage	4
Context-dependent activation of p53 target genes and induction of apoptosis by actinomycin D in aerodigestive tract cancers	4
AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via BadSer136 phosphorylation	4
Advances in tumor nanotechnology: theragnostic implications in tumors via targeting regulated cell death	4
Activated p53 in the anti-apoptotic milieu of tuberous sclerosis gene mutation induced diseases leads to cell death if thioredoxin reductase is inhibited	4
IRF-1-inhibited lncRNA XIST regulated the osteogenic differentiation via miR-450b/FBXW7 axis	4
Zhongfeng Capsules protects against cerebral ischemia–reperfusion injury via mediating the phosphoinositide 3-kinase/Akt and toll-like receptor 4/nuclear factor kappa B signaling pathways by regulatin	4
Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission	4
The molecular mechanism of a novel derivative of BTO-956 induced apoptosis in human myelomonocytic lymphoma cells	4
Overview of genetic and epigenetic regulation of human papillomavirus and apoptosis in cervical cancer	4
Exploration of microRNA-106b-5p as a therapeutic target in intervertebral disc degeneration: a preclinical study	4
Targeting the Akt/PI3K/mTOR signaling pathway for complete eradication of keloid disease by sunitinib	4
Bufalin reverses cancer-associated fibroblast-mediated colorectal cancer metastasis by inhibiting the STAT3 signaling pathway	4
Design and cytotoxic evaluation via apoptotic and antiproliferative activity for novel 11(4-aminophenylamino)neocryptolepine on hepatocellular and colorectal cancer cells	4
Glucocorticoid-induced activation of NOX/ROS/NF-κB signaling in MSCs contributes to the development of GONFH	4
Cuprotosis clusters predict prognosis and immunotherapy response in low-grade glioma	4
Downregulation of circ-STK39 suppresses pancreatic cancer progression by sponging mir-140-3p and regulating TRAM2-mediated epithelial-mesenchymal transition	4
A quarter century of Apoptosis	4
Role of ferroptosis in food-borne mycotoxin-induced toxicities	4
Revealing the role of necroptosis microenvironment: FCGBP + tumor-associated macrophages drive primary liver cancer differentiation towards cHCC-CCA or iCCA	4
MicroRNA-22-3p in human umbilical cord mesenchymal stem cell-secreted exosomes inhibits granulosa cell apoptosis by targeting KLF6 and ATF4-ATF3-CHOP pathway in POF mice	4
LncRNA PVT1 delays skin photoaging by sequestering miR-551b-3p to release AQP3 expression via ceRNA mechanism	4
LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer	4
Role of APR3 in cancer: apoptosis, autophagy, oxidative stress, and cancer therapy	4
circTAB2 inhibits lung cancer proliferation, migration and invasion by sponging miR-3142 to upregulate GLIS2	4
A self-amplifying loop of TP53INP1 and P53 drives oxidative stress-induced apoptosis of bone marrow mesenchymal stem cells	4
Potential role of human umbilical cord stem cells-derived exosomes as novel molecular inhibitors of hepatocellular carcinoma growth	4
Contribution of endoplasmic reticulum stress, MAPK and PI3K/Akt pathways to the apoptotic death induced by a penicillin derivative in melanoma cells	4
Anticancer effect and apoptosis induction by azaflavanone derivative in human prostate cancer cells	4
Multiple myeloma with high expression of SLC7A11 is sensitive to erastin-induced ferroptosis	4
Enhancing or inhibiting apoptosis? The effects of ucMSC-Ex in the treatment of different degrees of traumatic pancreatitis	4
DJ-1-mediated p62 degradation delays intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus cells	4
The regulation of amino acid metabolism in tumor cell death: from the perspective of physiological functions	4
Mitophagy in health and disease. Molecular mechanisms, regulatory pathways, and therapeutic implications	4