Apoptosis

Article	Citations
Release mechanisms of major DAMPs	211
The function and mechanism of ferroptosis in cancer	115
Mechanism of interaction between autophagy and apoptosis in cancer	100
BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy	73
BCL-2 protein family: attractive targets for cancer therapy	65
Terpenoids’ anti-cancer effects: focus on autophagy	58
BAX-dependent mitochondrial pathway mediates the crosstalk between ferroptosis and apoptosis	52
Targeting of cancer cell death mechanisms by resveratrol: a review	52
Mechanisms of cancer cell death induction by paclitaxel: an updated review	50
Programmed cell death detection methods: a systematic review and a categorical comparison	45
The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases	41
Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/reperfusion rats	40
Ca2+ overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells	39
COVID-19 disrupts spermatogenesis through the oxidative stress pathway following induction of apoptosis	32
Programmed cell death, redox imbalance, and cancer therapeutics	32
Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death	31
FTO inhibits UPRmt-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes	30
Progesterone induces apoptosis by activation of caspase-8 and calcitriol via activation of caspase-9 pathways in ovarian and endometrial cancer cells in vitro	30
Apoptosis in Alzheimer’s disease: insight into the signaling pathways and therapeutic avenues	29
Photodynamic therapy: apoptosis, paraptosis and beyond	29
New insights into targeting mitochondria in ischemic injury	26
Acetylcholinesterase promotes apoptosis in insect neurons	25
Circumventing the Crabtree effect: forcing oxidative phosphorylation (OXPHOS) via galactose medium increases sensitivity of HepG2 cells to the purine derivative kinetin riboside	24
Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax	23
Nobiletin as an inducer of programmed cell death in cancer: a review	23

XIAP as a multifaceted molecule in Cellular Signaling	22
Pyroptosis in acute pancreatitis and its therapeutic regulation	22
Apoptosis induced by SARS-CoV-2: can we target it?	21
Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells	21
Regulation of autophagy of the heart in ischemia and reperfusion	20
A potent protective effect of baicalein on liver injury by regulating mitochondria-related apoptosis	20
Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation	20
Gedunin isolated from the mangrove plant Xylocarpus granatum exerts its anti-proliferative activity in ovarian cancer cells through G2/M-phase arrest and oxidative stress-mediated intrinsic apoptosis	19
miR-21 protects neonatal rats from hypoxic-ischemic brain damage by targeting CCL3	18
Ischemia reperfusion injury induces pyroptosis and mediates injury in steatotic liver thorough Caspase 1 activation	18
DNA damage induces STING mediated IL-6-STAT3 survival pathway in triple-negative breast cancer cells and decreased survival of breast cancer patients	18
The regulation of necroptosis and perspectives for the development of new drugs preventing ischemic/reperfusion of cardiac injury	18
COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampus	18
The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD+ redox state	18
Intracellular leucine-rich alpha-2-glycoprotein-1 competes with Apaf-1 for binding cytochrome c in protecting MCF-7 breast cancer cells from apoptosis	18
Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects	17
Citarinostat and Momelotinib co-target HDAC6 and JAK2/STAT3 in lymphoid malignant cell lines: a potential new therapeutic combination	17
Soluble receptor for advanced glycation end-products promotes angiogenesis through activation of STAT3 in myocardial ischemia/reperfusion injury	17
Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins	16
miR-30b-5p inhibits cancer progression and enhances cisplatin sensitivity in lung cancer through targeting LRP8	16
Regulatory T cells are less sensitive to glucocorticoid hormone induced apoptosis than CD4+ T cells	16
Maslinic acid differentially exploits the MAPK pathway in estrogen-positive and triple-negative breast cancer to induce mitochondrion-mediated, caspase-independent apoptosis	16
Interconnections among major forms of regulated cell death	16
The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis	16
Casein kinase 1α mediates eryptosis: a review	15
Human umbilical cord mesenchymal stem cell-derived exosomes carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2 polarization and prevent colorectal liver metastasis	15
p53 m6A modulation sensitizes hepatocellular carcinoma to apatinib through apoptosis	15
Heat shock proteins-driven stress granule dynamics: yet another avenue for cell survival	15
m6A writer WTAP targets NRF2 to accelerate bladder cancer malignancy via m6A-dependent ferroptosis regulation	14
The pro-apoptotic ARTS protein induces neutrophil apoptosis, efferocytosis, and macrophage reprogramming to promote resolution of inflammation	14
LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis	14
Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells	14
Pyroptosis, a target for cancer treatment?	13
Triclosan induces apoptosis in Burkitt lymphoma-derived BJAB cells through caspase and JNK/MAPK pathways	13
Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis	13
The interplay between apoptosis and ferroptosis mediated by ER stress	13
Regulation of autophagy as a therapeutic option in glioblastoma	12
Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis	12
Upregulation of microRNA-532 enhances cardiomyocyte apoptosis in the diabetic heart	12
Role of apoptosis repressor with caspase recruitment domain (ARC) in cell death and cardiovascular disease	12
LncRNA FGD5-AS1 promotes the malignant phenotypes of ovarian cancer cells via targeting miR-142-5p	12
Cardiac Mitochondrial PTEN-L determines cell fate between apoptosis and survival during chronic alcohol consumption	12
Cuproptosis identifies respiratory subtype of renal cancer that confers favorable prognosis	12
Valproic acid upregulates the expression of the p75NTR/sortilin receptor complex to induce neuronal apoptosis	12
Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated interverte	12
Tumor cell-derived exosome RNF126 affects the immune microenvironment and promotes nasopharyngeal carcinoma progression by regulating PTEN ubiquitination	12
The delay in cell death caused by the induction of autophagy by P2Et extract is essential for the generation of immunogenic signals in melanoma cells	11
The role of lncRNA OIP5-AS1 in cancer development and progression	11
Ambra1 regulates apoptosis and chemosensitivity in breast cancer cells through the Akt-FoxO1-Bim pathway	11
Epoxyazadiradione exhibit activities in head and neck squamous cell carcinoma by targeting multiple pathways	11

Doxorubicin sensitizes cancer cells to Smac mimetic via synergistic activation of the CYLD/RIPK1/FADD/caspase-8-dependent apoptosis	11
N6-methyladenosine writer METTL3 accelerates the sepsis-induced myocardial injury by regulating m6A-dependent ferroptosis	11
Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1	10
Molecular mechanisms of cell death in bronchopulmonary dysplasia	10
The role of the DFF40/CAD endonuclease in genomic stability	10
Phosphodiesterase 5 inhibitor sildenafil potentiates the antitumor activity of cisplatin by ROS-mediated apoptosis: a role of deregulated glucose metabolism	10
Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway	10
Inhibition of miR-130b-3p restores autophagy and attenuates intervertebral disc degeneration through mediating ATG14 and PRKAA1	10
Benzofuran pyran hybrid prevents glucocorticoid induced osteoporosis in mice via modulation of canonical Wnt/β-catenin signaling	9
Understanding the mechanistic roles of environmental heavy metal stressors in regulating ferroptosis: adding new paradigms to the links with diseases	9
Targeting lipid metabolism for ferroptotic cancer therapy	9
The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells	9
RAB25 confers resistance to chemotherapy by altering mitochondrial apoptosis signaling in ovarian cancer cells	9
High glucose-induced ROS-accumulation in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis	9
H2S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434	9
Piperlongumine, a piper alkaloid, enhances the efficacy of doxorubicin in breast cancer: involvement of glucose import, ROS, NF-κB and lncRNAs	9
LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis	9
CACNA1C-AS2 inhibits cell proliferation and suppresses cell migration and invasion via targeting FBXO45 and PI3K/AKT/mTOR pathways in glioma	8
Targeting mitochondria as a therapeutic anti-gastric cancer approach	8
Apoptotic proteins with non-apoptotic activity: expression and function in cancer	8
WNT signaling modulates chemoresistance to temozolomide in p53-mutant glioblastoma multiforme	8
Antiproliferative effect of bacterial cyclodipeptides in the HeLa line of human cervical cancer reveals multiple protein kinase targeting, including mTORC1/C2 complex inhibition in a TSC1/2-dependent	7
The functions of lncRNAs in the HPV-negative cervical cancer compared with HPV-positive cervical cancer	7
Targeting ferroptosis: a novel insight against myocardial infarction and ischemia–reperfusion injuries	7
The α7 and β2 nicotinic acetylcholine receptor subunits regulate apoptosis in the infant hippocampus, and in sudden infant death syndrome (SIDS)	7
Role of C-terminal domain of Mycobacterium tuberculosis PE6 (Rv0335c) protein in host mitochondrial stress and macrophage apoptosis	7
High-dose copper activates p53-independent apoptosis through the induction of nucleolar stress in human cell lines	7
NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer	7
The regulation of necroptosis by ubiquitylation	7
Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis	7
MicroRNA-136-5p protects cardiomyocytes from coronary microembolization through the inhibition of pyroptosis	7
Neuroprotective effect of 3,3’-Diindolylmethane against perinatal asphyxia involves inhibition of the AhR and NMDA signaling and hypermethylation of specific genes	7
c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia	7
Activation of β1 integrins and caveolin-1 by TF/FVIIa promotes IGF-1R signaling and cell survival	7
Programmed cell death lives	6
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration	6
JNK-dependent phosphorylation and nuclear translocation of EGR-1 promotes cardiomyocyte apoptosis	6
Hypobaric hypoxia triggers pyroptosis in the retina via NLRP3 inflammasome activation	6
Exploring the MEN1 dependent modulation of caspase 8 and caspase 3 in human pancreatic and murine embryo fibroblast cells	6
mTOR deletion ameliorates CD4 + T cell apoptosis during sepsis by improving autophagosome-lysosome fusion	6
Regulation of alveolar macrophage death in pulmonary fibrosis: a review	6
Hypoxic condition induced H3K27me3 modification of the LncRNA Tmem235 promoter thus supporting apoptosis of BMSCs	6
Dysfunctions, molecular mechanisms, and therapeutic strategies of pancreatic β-cells in diabetes	6
ML323, a USP1 inhibitor triggers cell cycle arrest, apoptosis and autophagy in esophageal squamous cell carcinoma cells	6
Crosstalk of ferroptosis regulators and tumor immunity in pancreatic adenocarcinoma: novel perspective to mRNA vaccines and personalized immunotherapy	6
Bufalin targeting BFAR inhibits the occurrence and metastasis of gastric cancer through PI3K/AKT/mTOR signal pathway	6
Fluorizoline-induced apoptosis requires prohibitins in nematodes and human cells	6
Neutrophil extracellular traps mediate TLR9/Merlin axis to resist ferroptosis and promote triple negative breast cancer progression	6
microRNA-944 inhibits breast cancer cell proliferation and promotes cell apoptosis by reducing SPP1 through inactivating the PI3K/Akt pathway	5
Improved antitumor immunity of chemotherapy in OSCC treatment by Gasdermin-E mediated pyroptosis	5
Flow cytometric detection of hyper-polarized mitochondria in regulated and accidental cell death processes	5
Cuproptosis-related LncRNA signatures as a prognostic model for head and neck squamous cell carcinoma	5
Acetic acid triggers cytochrome c release in yeast heterologously expressing human Bax	5
Let-7a-5p regulated by lncRNA-MEG3 promotes functional differentiation to Schwann cells from adipose derived stem cells via directly inhibiting RBPJ-mediating Notch pathway	5
Adipose mesenchymal stem cells-derived exosomes alleviate osteoarthritis by transporting microRNA -376c-3p and targeting the WNT-beta-catenin signaling axis	5
FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated redox homeostasis	5
Acetylcholine exerts cytoprotection against hypoxia/reoxygenation-induced apoptosis, autophagy and mitochondrial impairment through both muscarinic and nicotinic receptors	5
DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis	5
Up-regulation of pro-angiogenic molecules and events does not relate with an angiogenic switch in metastatic osteosarcoma cells but to cell survival features	5
Vitamin D3 affects browning of white adipocytes by regulating autophagy via PI3K/Akt/mTOR/p53 signaling in vitro and in vivo	5
Long-circulating XTEN864-annexin A5 fusion protein for phosphatidylserine-related therapeutic applications	5
Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic	5
Circ_0000523 regulates miR-1184/COL1A1/PI3K/Akt pathway to promote nasopharyngeal carcinoma progression	5
The cross-talk between Bax, Bcl2, caspases, and DNA damage in bystander HepG2 cells is regulated by γ-radiation dose and time of conditioned media transfer	5
Comprehensive analysis of mitochondrial dysfunction and necroptosis in intracranial aneurysms from the perspective of predictive, preventative, and personalized  medicine	4
Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives	4
Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure	4
Overview of genetic and epigenetic regulation of human papillomavirus and apoptosis in cervical cancer	4
Phloretin induces G2/M arrest and apoptosis by suppressing the β-catenin signaling pathway in colorectal carcinoma cells	4
Long non-coding RNA SNHG4 enhances RNF14 mRNA stability to promote the progression of colorectal cancer by recruiting TAF15 protein	4
Combination of a p53-activating CP-31398 and an MDM2 or a FAK inhibitor produces growth suppressive effects in mesothelioma with wild-type p53 genotype	4
A quarter century of Apoptosis	4
The deubiquitinase Usp27x as a novel regulator of cFLIPL protein expression and sensitizer to death-receptor-induced apoptosis	4
Targeting lysophosphatidic acid receptor with Ki16425 impedes T cell lymphoma progression through apoptosis induction, glycolysis inhibition, and activation of antitumor immune response	4
A novel 8-hydroxyquinoline derivative induces breast cancer cell death through paraptosis and apoptosis	4
Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3/SLC7A11 axis	4
Zhongfeng Capsules protects against cerebral ischemia–reperfusion injury via mediating the phosphoinositide 3-kinase/Akt and toll-like receptor 4/nuclear factor kappa B signaling pathways by regulatin	4
Escaping cell death via TRAIL decoy receptors: a systematic review of their roles and expressions in colorectal cancer	4
The function of RNase L and its degradation mechanism in cardiac acute ischemic injury	4
The histone deacetylase SIRT6 promotes glycolysis through the HIF-1α/HK2 signaling axis and induces erlotinib resistance in non-small cell lung cancer	4

The intricate relationship between autoimmunity disease and neutrophils death patterns: a love-hate story	4
circTAB2 inhibits lung cancer proliferation, migration and invasion by sponging miR-3142 to upregulate GLIS2	4
Contribution of endoplasmic reticulum stress, MAPK and PI3K/Akt pathways to the apoptotic death induced by a penicillin derivative in melanoma cells	4
Integrinβ3 mediates the protective effects of soluble receptor for advanced glycation end-products during myocardial ischemia/reperfusion through AKT/STAT3 signaling pathway	4
Modulation of lung cytoskeletal remodeling, RXR based metabolic cascades and inflammation to achieve redox homeostasis during extended exposures to lowered pO2	3
Forcing dividing cancer cells to die; low‐dose drug combinations to prevent spindle pole clustering	3
The unfolded protein response (UPR) pathway: the unsung hero in breast cancer management	3
Tumor-suppressive E3 ubiquitin ligase CHIP inhibits the PBK/ERK axis to repress stem cell properties and radioresistance in non-small cell lung cancer	3
Gamma irradiation induces a pro-apoptotic state in longer stored platelets, without progressing to an overt apoptosis by day 7 of storage	3
Triptolide induces PANoptosis in macrophages and causes organ injury in mice	3
Enhancing or inhibiting apoptosis? The effects of ucMSC-Ex in the treatment of different degrees of traumatic pancreatitis	3
The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action	3
Rational design of genetically encoded reporter genes for optical imaging of apoptosis	3
The therapeutic strategy of drug re-positioning to induce autophagic cell death in brain malignancy	3
TFAM-Mediated mitochondrial transfer of MSCs improved the permeability barrier in sepsis-associated acute lung injury	3
Excessive hydrogen sulfide causes lung and brain tissue damage by promoting PARP1/Bax and C9 and inhibiting LAMB1	3
Genipin protects against acute liver injury by abrogating ferroptosis via modification of GPX4 and ALOX15-launched lipid peroxidation in mice	3
Intensive stretch-activated CRT-PMCA1 feedback loop promoted apoptosis of myoblasts through Ca2+ overloading	3
The molecular mechanism of a novel derivative of BTO-956 induced apoptosis in human myelomonocytic lymphoma cells	3
P2Y1 agonist HIC in combination with androgen receptor inhibitor abiraterone acetate impairs cell growth of prostate cancer	3
Monitoring yeast regulated cell death: trespassing the point of no return to loss of plasma membrane integrity	3
Role of Escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin	3
Rictor, an essential component of mTOR complex 2, undergoes caspase-mediated cleavage during apoptosis induced by multiple stimuli	3
Obstructive sleep apnea-increased DEC1 regulates systemic inflammation and oxidative stress that promotes development of pulmonary arterial hypertension	3
Novel PET/CT tracers for targeted imaging of membrane receptors to evaluate cardiomyocyte apoptosis and tissue repair process in a rat model of myocardial infarction	3
Context-dependent activation of p53 target genes and induction of apoptosis by actinomycin D in aerodigestive tract cancers	3
Meta analysis of bioactive compounds, miRNA, siRNA and cell death regulators as sensitizers to doxorubicin induced chemoresistance	3
Selective CDK9 knockdown sensitizes TRAIL response by suppression of antiapoptotic factors and NF-kappaB pathway	3
Apoptosis and eryptosis: similarities and differences	3
GAS6/Axl is associated with AMPK activation and attenuates H2O2-induced oxidative stress	3
Cancer-associated fibroblasts promote malignant phenotypes of prostate cancer cells via autophagy	3
Anti-neoplastic pharmacophore benzophenone-1 coumarin (BP-1C) targets JAK2 to induce apoptosis in lung cancer	3
Ferroptosis: underlying mechanisms and involvement in neurodegenerative diseases	3
Mild hypothermia alleviates oxygen−glucose deprivation/reperfusion-induced apoptosis by inhibiting ROS generation, improving mitochondrial dysfunction and regulating DNA damage repair pathway in PC12	3
Anticancer effect and apoptosis induction by azaflavanone derivative in human prostate cancer cells	3
Targeting the Akt/PI3K/mTOR signaling pathway for complete eradication of keloid disease by sunitinib	3
MEG3 alleviates ankylosing spondylitis by suppressing osteogenic differentiation of mesenchymal stem cells through regulating microRNA-125a-5p-mediated TNFAIP3	3
The natural product dehydrocurvularin induces apoptosis of gastric cancer cells by activating PARP-1 and caspase-3	3