OOIR: Observatory of International Research

Papers

(The TQCC of Cytokine & Growth Factor Reviews is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Editorial Board	147
Potential effects of HMGB1 on viral replication and virus infection-induced inflammatory responses: A promising therapeutic target for virus infection-induced inflammatory diseases	139
COVID-19: From emerging variants to vaccination	119
COVID-19 as a mediator of interferon deficiency and hyperinflammation: Rationale for the use of JAK1/2 inhibitors in combination with interferon	114
Unveiling cytokine charge disparity as a potential mechanism for immune regulation	112
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions	96
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs	94
Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics	79
Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism	76
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy	75
Editorial Board	74
Editorial Board	67
Editorial Board	67
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects	65
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances	63
Participation of interferons in psoriatic inflammation	63
Molecular mechanisms of regulation of IL-1 and its receptors	60
Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration	59
Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection	58
Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms	54
The immunosuppressive and pro-tumor functions of CCL18 at the tumor microenvironment	52
TGF-β mediated drug resistance in solid cancer	51
Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation	51
Pro-angiogenic activity and vasculogenic mimicry in the tumor microenvironment by leptin in cancer	47
Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets	46

Exogenous drug-induced mouse models of atopic dermatitis	45
Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence	45
Current utilization of interferon alpha for the treatment of coronavirus disease 2019: A comprehensive review	44
Principles of the activin receptor signaling pathway and its inhibition	43
Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis	43
Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis	41
The cGAS-STING pathway: Post-translational modifications and functional implications in diseases	40
Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2	38
Suppressor of cytokine signaling 6 in cancer development and therapy: Deciphering its emerging and suppressive roles	38
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells	37
COVID-19 and dys-regulation of pulmonary endothelium: implications for vascular remodeling	37
Exosomes as a modulator of immune resistance in human cancers	36
MDSCs might be “Achilles heel” for eradicating CSCs	36
Multifaceted role of CD14 in innate immunity and tissue homeostasis	35
Neurotrophic factors and their receptors in lung development and implications in lung diseases	35
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	34
Decoding the roles of heat shock proteins in liver cancer	34
Editorial Board	34
The IFN-γ/miniTrpRS signaling axis: An insight into the pathophysiology of osteoporosis and therapeutic potential	33
The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies	33
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases	33
Exploring Inflammatory and Fibrotic Mechanisms Driving Diabetic Nephropathy Progression	32
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	30
Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy	30
Netrin-1: An emerging player in inflammatory diseases	28
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands	28
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights	28
B cell-activating factor and its targeted therapy in autoimmune diseases	28
Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer	27
The impact of adipokines on vascular networks in adipose tissue	27
Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities	27
Forgetting COVID-19 – Introduction to the special issue	27
Chemokine networks modulating natural killer cell trafficking to solid tumors	27
The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance	26
Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism	25
mTOR in programmed cell death and its therapeutic implications	24
Therapeutic inhibition of the JAK-STAT pathway in the treatment of inflammatory bowel disease	23
Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation	23
Editorial Board	23