OOIR: Observatory of International Research

Papers

(The TQCC of Cytokine & Growth Factor Reviews is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Editorial Board	140
Unveiling cytokine charge disparity as a potential mechanism for immune regulation	136
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions	116
Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics	109
COVID-19 as a mediator of interferon deficiency and hyperinflammation: Rationale for the use of JAK1/2 inhibitors in combination with interferon	105
Potential effects of HMGB1 on viral replication and virus infection-induced inflammatory responses: A promising therapeutic target for virus infection-induced inflammatory diseases	93
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs	89
COVID-19: From emerging variants to vaccination	77
Editorial Board	72
Editorial Board	71
Editorial Board	68
Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism	65
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy	64
Participation of interferons in psoriatic inflammation	62
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects	62
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances	61
Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms	58
Molecular mechanisms of regulation of IL-1 and its receptors	57
Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration	54
Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection	51
The immunosuppressive and pro-tumor functions of CCL18 at the tumor microenvironment	50
Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation	49
Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets	48
Pro-angiogenic activity and vasculogenic mimicry in the tumor microenvironment by leptin in cancer	47
Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence	44

Exogenous drug-induced mouse models of atopic dermatitis	44
TGF-β mediated drug resistance in solid cancer	43
Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis	42
Current utilization of interferon alpha for the treatment of coronavirus disease 2019: A comprehensive review	42
Suppressor of cytokine signaling 6 in cancer development and therapy: Deciphering its emerging and suppressive roles	42
Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis	40
Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2	37
Principles of the activin receptor signaling pathway and its inhibition	37
The cGAS-STING pathway: Post-translational modifications and functional implications in diseases	36
Neurotrophic factors and their receptors in lung development and implications in lung diseases	35
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells	35
Exosomes as a modulator of immune resistance in human cancers	35
COVID-19 and dys-regulation of pulmonary endothelium: implications for vascular remodeling	34
Multifaceted role of CD14 in innate immunity and tissue homeostasis	34
MDSCs might be “Achilles heel” for eradicating CSCs	33
Decoding the roles of heat shock proteins in liver cancer	31
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	31
Editorial Board	31
The IFN-γ/miniTrpRS signaling axis: An insight into the pathophysiology of osteoporosis and therapeutic potential	31
B cell-activating factor and its targeted therapy in autoimmune diseases	30
The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies	30
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases	29
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands	29
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	28
Netrin-1: An emerging player in inflammatory diseases	28
The impact of adipokines on vascular networks in adipose tissue	27
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights	27
Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy	27
Chemokine networks modulating natural killer cell trafficking to solid tumors	26
Forgetting COVID-19 – Introduction to the special issue	26
Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities	25
The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance	25
Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation	24
Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer	24
Therapeutic inhibition of the JAK-STAT pathway in the treatment of inflammatory bowel disease	24
Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism	23
mTOR in programmed cell death and its therapeutic implications	23