OOIR: Observatory of International Research

Papers

(The TQCC of Cytokine & Growth Factor Reviews is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Editorial Board	216
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs	151
Unveiling cytokine charge disparity as a potential mechanism for immune regulation	148
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions	132
COVID-19: From emerging variants to vaccination	126
Editorial Board	125
Editorial Board	109
Editorial Board	99
Erratum to “TLR-Based therapeutic strategies for Hepatocellular carcinoma” [Cytokine Growth Factor Rev. Volume 85 2025 Pages 179–189]	97
Metabolic Regulation of cGAS-STING Signaling in the Tumor Microenvironment: Dual Immune Roles and Therapeutic Implications	87
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects	80
Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism	78
Participation of interferons in psoriatic inflammation	70
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy	70
Targeting cytokines: Reshaping the pancreatic tumor microenvironment	68
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances	67
Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration	65
Cytokine symphony: Deciphering the tumor microenvironment and metastatic axis in oral cancer	61
Molecular mechanisms of regulation of IL-1 and its receptors	60
Natural killers or natural regulators? Dual roles of NK cells in checkpoint immunotherapy	60
Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection	54
Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets	50
Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation	48
Exogenous drug-induced mouse models of atopic dermatitis	47
TGF-β mediated drug resistance in solid cancer	45

Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis	45
Suppressor of cytokine signaling 6 in cancer development and therapy: Deciphering its emerging and suppressive roles	44
Current utilization of interferon alpha for the treatment of coronavirus disease 2019: A comprehensive review	41
Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2	40
Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis	40
The cGAS-STING pathway: Post-translational modifications and functional implications in diseases	40
MDSCs might be “Achilles heel” for eradicating CSCs	39
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells	38
Multifaceted role of CD14 in innate immunity and tissue homeostasis	37
Exosomes as a modulator of immune resistance in human cancers	37
COVID-19 and dys-regulation of pulmonary endothelium: implications for vascular remodeling	37
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	36
Editorial Board	35
The IFN-γ/miniTrpRS signaling axis: An insight into the pathophysiology of osteoporosis and therapeutic potential	35
Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy	33
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands	33
Decoding the roles of heat shock proteins in liver cancer	33
Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies	33
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	32
B cell-activating factor and its targeted therapy in autoimmune diseases	32
Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression	31
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights	30
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases	30
Netrin-1: An emerging player in inflammatory diseases	30
The impact of adipokines on vascular networks in adipose tissue	30
From senescence to scarring: Exploring TGF-β signaling in cellular aging, fibrotic remodeling, and pulmonary fibrosis	29
Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities	29
Forgetting COVID-19 – Introduction to the special issue	29
Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer	28
The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance	28
Therapeutic inhibition of the JAK-STAT pathway in the treatment of inflammatory bowel disease	28
Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism	27
mTOR in programmed cell death and its therapeutic implications	27
Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation	27
Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders	26
Editorial Board	26
Cholecystokinin and gastrin as immune modulating hormones: Implications and applications	26
Glioblastoma-associated macrophages: A key target in overcoming glioblastoma therapeutic resistance	26
Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy	24
Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression	24