OOIR: Observatory of International Research

Papers

(The TQCC of Cytokine & Growth Factor Reviews is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Editorial Board	265
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs	144
Corrigendum to “Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy” [Cytokine Growth Factor Rev. 84 (2025) 59–73]	142
COVID-19: From emerging variants to vaccination	129
Unveiling cytokine charge disparity as a potential mechanism for immune regulation	123
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions	116
Editorial Board	115
Editorial Board	87
Erratum to “TLR-Based therapeutic strategies for Hepatocellular carcinoma” [Cytokine Growth Factor Rev. Volume 85 2025 Pages 179–189]	82
Editorial Board	82
Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism	80
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects	73
Metabolic Regulation of cGAS-STING Signaling in the Tumor Microenvironment: Dual Immune Roles and Therapeutic Implications	72
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy	72
Targeting cytokines: Reshaping the pancreatic tumor microenvironment	68
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances	63
Molecular mechanisms of regulation of IL-1 and its receptors	61
Natural killers or natural regulators? Dual roles of NK cells in checkpoint immunotherapy	58
Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration	53
Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection	48
Exogenous drug-induced mouse models of atopic dermatitis	47
Cytokine symphony: Deciphering the tumor microenvironment and metastatic axis in oral cancer	47
TGF-β mediated drug resistance in solid cancer	45
Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets	45
Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation	43

Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis	43
Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2	43
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	42
Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis	42
The cGAS-STING pathway: Post-translational modifications and functional implications in diseases	42
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells	40
Exosomes as a modulator of immune resistance in human cancers	40
MDSCs might be “Achilles heel” for eradicating CSCs	40
Multifaceted role of CD14 in innate immunity and tissue homeostasis	40
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	39
Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression	39
Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies	39
Editorial Board	38
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases	38
Decoding the roles of heat shock proteins in liver cancer	38
The role of neurotransmitter signaling in colorectal cancer progression: Opportunities for drug repurposing	37
Post COVID-19 pandemic Inflammatory Insights into Cancer: Consequences for immunotherapy	37
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands	37
Forgetting COVID-19 – Introduction to the special issue	36
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights	35
From senescence to scarring: Exploring TGF-β signaling in cellular aging, fibrotic remodeling, and pulmonary fibrosis	35
Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities	34
The impact of adipokines on vascular networks in adipose tissue	34
Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer	32
The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance	31
Therapeutic inhibition of the JAK-STAT pathway in the treatment of inflammatory bowel disease	31
Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism	31
Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation	31
Spatiotemporal dynamic regulation of the CX3CL1-CX3CR1 axis: A double-edged sword in the tumor immune microenvironment and new strategies for precision therapy	30
mTOR in programmed cell death and its therapeutic implications	30
Nefarious NTRK oncogenic fusions in pediatric sarcomas: Too many to Trk	30
Glioblastoma-associated macrophages: A key target in overcoming glioblastoma therapeutic resistance	30
Cholecystokinin and gastrin as immune modulating hormones: Implications and applications	28
Editorial Board	28
Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders	27
Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression	27
Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy	26
Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer	26
Unraveling the intricacies of neutrophil extracellular traps in inflammatory bowel disease: Pathways, biomarkers, and promising therapies	26
Could IL-25 be a potential therapeutic target for intestinal inflammatory diseases?	26