OOIR: Observatory of International Research

Papers

(The TQCC of Cytokine & Growth Factor Reviews is 21. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Editorial Board	165
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions	141
Potential effects of HMGB1 on viral replication and virus infection-induced inflammatory responses: A promising therapeutic target for virus infection-induced inflammatory diseases	123
COVID-19 as a mediator of interferon deficiency and hyperinflammation: Rationale for the use of JAK1/2 inhibitors in combination with interferon	123
COVID-19: From emerging variants to vaccination	110
Unveiling cytokine charge disparity as a potential mechanism for immune regulation	106
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs	89
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects	86
Editorial Board	84
Editorial Board	77
Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism	71
Editorial Board	71
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy	69
Metabolic Regulation of cGAS-STING Signaling in the Tumor Microenvironment: Dual Immune Roles and Therapeutic Implications	67
Participation of interferons in psoriatic inflammation	65
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances	62
Cytokine symphony: Deciphering the tumor microenvironment and metastatic axis in oral cancer	56
Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration	55
Molecular mechanisms of regulation of IL-1 and its receptors	52
The immunosuppressive and pro-tumor functions of CCL18 at the tumor microenvironment	51
Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms	50
Pro-angiogenic activity and vasculogenic mimicry in the tumor microenvironment by leptin in cancer	50
Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection	50
Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation	47
Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets	47

Exogenous drug-induced mouse models of atopic dermatitis	46
TGF-β mediated drug resistance in solid cancer	44
Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence	44
Suppressor of cytokine signaling 6 in cancer development and therapy: Deciphering its emerging and suppressive roles	43
Current utilization of interferon alpha for the treatment of coronavirus disease 2019: A comprehensive review	43
Principles of the activin receptor signaling pathway and its inhibition	41
The cGAS-STING pathway: Post-translational modifications and functional implications in diseases	39
Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis	39
Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis	38
Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2	37
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	36
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells	36
MDSCs might be “Achilles heel” for eradicating CSCs	36
Exosomes as a modulator of immune resistance in human cancers	36
COVID-19 and dys-regulation of pulmonary endothelium: implications for vascular remodeling	36
Multifaceted role of CD14 in innate immunity and tissue homeostasis	34
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands	33
Editorial Board	33
B cell-activating factor and its targeted therapy in autoimmune diseases	32
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	31
The IFN-γ/miniTrpRS signaling axis: An insight into the pathophysiology of osteoporosis and therapeutic potential	31
Netrin-1: An emerging player in inflammatory diseases	30
Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression	30
Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy	29
The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies	29
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights	28
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases	28
Decoding the roles of heat shock proteins in liver cancer	28
The impact of adipokines on vascular networks in adipose tissue	26
Forgetting COVID-19 – Introduction to the special issue	26
Therapeutic inhibition of the JAK-STAT pathway in the treatment of inflammatory bowel disease	25
Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism	24
Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer	24
Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation	23
Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities	23
The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance	22
Editorial Board	22
mTOR in programmed cell death and its therapeutic implications	22
Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders	21
Cholecystokinin and gastrin as immune modulating hormones: Implications and applications	21