OOIR: Observatory of International Research

Papers

(The median citation count of Cytokine & Growth Factor Reviews is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Editorial Board	216
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs	151
Unveiling cytokine charge disparity as a potential mechanism for immune regulation	148
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions	132
COVID-19: From emerging variants to vaccination	126
Editorial Board	125
Editorial Board	109
Editorial Board	99
Erratum to “TLR-Based therapeutic strategies for Hepatocellular carcinoma” [Cytokine Growth Factor Rev. Volume 85 2025 Pages 179–189]	97
Metabolic Regulation of cGAS-STING Signaling in the Tumor Microenvironment: Dual Immune Roles and Therapeutic Implications	87
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects	80
Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism	78
Participation of interferons in psoriatic inflammation	70
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy	70
Targeting cytokines: Reshaping the pancreatic tumor microenvironment	68
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances	67
Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration	65
Cytokine symphony: Deciphering the tumor microenvironment and metastatic axis in oral cancer	61
Natural killers or natural regulators? Dual roles of NK cells in checkpoint immunotherapy	60
Molecular mechanisms of regulation of IL-1 and its receptors	60
Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection	54
Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets	50
Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation	48
Exogenous drug-induced mouse models of atopic dermatitis	47
Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis	45

TGF-β mediated drug resistance in solid cancer	45
Suppressor of cytokine signaling 6 in cancer development and therapy: Deciphering its emerging and suppressive roles	44
Current utilization of interferon alpha for the treatment of coronavirus disease 2019: A comprehensive review	41
The cGAS-STING pathway: Post-translational modifications and functional implications in diseases	40
Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2	40
Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis	40
MDSCs might be “Achilles heel” for eradicating CSCs	39
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells	38
COVID-19 and dys-regulation of pulmonary endothelium: implications for vascular remodeling	37
Multifaceted role of CD14 in innate immunity and tissue homeostasis	37
Exosomes as a modulator of immune resistance in human cancers	37
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	36
Editorial Board	35
The IFN-γ/miniTrpRS signaling axis: An insight into the pathophysiology of osteoporosis and therapeutic potential	35
Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy	33
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands	33
Decoding the roles of heat shock proteins in liver cancer	33
Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies	33
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	32
B cell-activating factor and its targeted therapy in autoimmune diseases	32
Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression	31
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights	30
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases	30
Netrin-1: An emerging player in inflammatory diseases	30
The impact of adipokines on vascular networks in adipose tissue	30
Forgetting COVID-19 – Introduction to the special issue	29
From senescence to scarring: Exploring TGF-β signaling in cellular aging, fibrotic remodeling, and pulmonary fibrosis	29
Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities	29
Therapeutic inhibition of the JAK-STAT pathway in the treatment of inflammatory bowel disease	28
Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer	28
The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance	28
Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation	27
Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism	27
mTOR in programmed cell death and its therapeutic implications	27
Glioblastoma-associated macrophages: A key target in overcoming glioblastoma therapeutic resistance	26
Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders	26
Editorial Board	26
Cholecystokinin and gastrin as immune modulating hormones: Implications and applications	26
Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression	24
Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy	24
Multiple post-translational modifications ensure EGFR functionality: Potential therapeutic targets to overcome its drug-resistance mutations	23
Nefarious NTRK oncogenic fusions in pediatric sarcomas: Too many to Trk	23
Uncovering key mechanisms and intervention therapies in aging skin	23
Could IL-25 be a potential therapeutic target for intestinal inflammatory diseases?	23
JAK inhibitors in immune regulation and treatment of vitiligo	23
Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer	23
The IL-2A receptor pathway and its role in lymphocyte differentiation and function	23
Unraveling the intricacies of neutrophil extracellular traps in inflammatory bowel disease: Pathways, biomarkers, and promising therapies	22
Alternative pathways driven by STING: From innate immunity to lipid metabolism	22
Mechanisms and routes of G-protein coupled receptor-mediated Tau degradation in Alzheimer’s disease	22

The critical role of osteopontin (OPN) in fibrotic diseases	22
The journey of STING: Guiding immune signaling through membrane trafficking	22
Regulation of regulated cell death by extracellular vesicles in acute kidney injury and chronic kidney disease	20
Leptin as a mechanistic link between obesity and systemic lupus erythematous	20
Cancer-associated fibroblasts: Vital suppressors of the immune response in the tumor microenvironment	20
The activin-follistatin system: Key regulator of kidney development, regeneration, inflammation, and fibrosis	20
The functional roles of m6A modification in T lymphocyte responses and autoimmune diseases	19
T cell receptor signaling in the differentiation and plasticity of CD4+ T cells	19
Editorial Board	19
Retard or exacerbate: Role of long non-coding RNA growth arrest-specific 5 in the fibrosis	19
LC3B: A microtubule-associated protein influences disease progression and prognosis	19
GLP-1R agonist therapy and vaccine response: Neglected implications	18
Macrophage migration inhibitor factor (MIF): Potential role in cognitive impairment disorders	18
The anti-inflammatory effects of itaconate and its derivatives in neurological disorders	17
An emerging paradigm of CXCL16 involvement in cancer progression	17
Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury	17
Endothelial and macrophage interactions in the angiogenic niche	17
Cytokines on the way to secretion	17
Decoding the neuroimmune axis in colorectal cancer: From neural circuitry to therapeutic innovation	17
Pharmacological therapies and drug development targeting SARS-CoV-2 infection	16
Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron	16
Pancreatic cancer exosomes: Their role in drug resistance and immunomodulation	16
Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases	16
Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy	15
Revisiting IRF1-mediated antiviral innate immunity	15
Exosome-mediated metabolic reprogramming: Implications in esophageal carcinoma progression and tumor microenvironment remodeling	15
Role of cytokine-based immunotherapy approaches in gastrointestinal cancers	15
The central role of CXCL10-CXCR3 signaling in neuroinflammation and neuropathology	15
Tightly bound T-cell clusters: A new class of hyper-effector tumor killers	15
SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities	14
The impact of cytokines in neuroinflammation-mediated stroke	13
Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus	13
Role of growth factors and their interplay during oligodendroglial differentiation and maturation	13
Role of lipid signalling in extracellular vesicles-mediated cell-to-cell communication	13
Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs	13
Assessment of clinical studies evaluating combinations of immune checkpoint inhibitors with locoregional treatments in solid tumors	13
The Coronavirus pandemic – 2022: Viruses, variants & vaccines	13
The involvement of TH17 cells in the pathogenesis of IBD	13
Editorial Board	12
The odyssey of cGAS: From cytosol to nucleus	12
Unveiling the role of IL-17: Therapeutic insights and cardiovascular implications	12
TLR-based therapeutic strategies for hepatocellular carcinoma	12
Targeting interleukin-17 in radiation-induced toxicity and cancer progression	12
Preexisting immunity: Barrier or bridge to effective oncolytic virus therapy?	11
Neuroprotective properties of ciliary neurotrophic factor in the retina for the treatment of macular telangiectasia type 2	11
BCR-ABL: The molecular mastermind behind chronic myeloid leukemia	11
Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors	11
The role of microglial activation on ischemic stroke: Modulation by fibroblast growth factors	11
Editorial Board	10
Neuro-endocrine-immune regulation of metabolic homeostasis	10
Cardiac and pericardial inflammatory changes and post-cardiac surgery atrial fibrillation	10
The evolving epidemiology of monkeypox virus	9
Cancer and Covid-19: Collectively catastrophic	9
Protein-protein interactions and related inhibitors involved in the NLRP3 inflammasome pathway	9
Granulocyte macrophage colony stimulating factor in virus-host interactions and its implication for immunotherapy	9
Acinar cells and the development of pancreatic fibrosis	9
The cytokine trio - visfatin, placental growth factor and fractalkine – and their role in myocardial infarction with non-obstructive coronary arteries (MINOCA)	9
Nanotechnology-based cytokine delivery strategies in gastrointestinal cancers	9