OOIR: Observatory of International Research

Papers

(The median citation count of Cytokine & Growth Factor Reviews is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Interleukin-6 (IL-6)-associated tumor microenvironment remodelling and cancer immunotherapy	120
Endothelial and macrophage interactions in the angiogenic niche	106
Roles of the gut microbiota in severe SARS-CoV-2 infection	103
Multifaceted role of CD14 in innate immunity and tissue homeostasis	99
MDSCs in sepsis-induced immunosuppression and its potential therapeutic targets	92
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	86
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs	76
Old drugs, new tricks: Emerging role of drug repurposing in the management of atopic dermatitis	74
Development of mRNA vaccines against respiratory syncytial virus (RSV)	65
Galectins as modulators of receptor tyrosine kinases signaling in health and disease	60
The anti-inflammatory effects of itaconate and its derivatives in neurological disorders	59
Editorial Board	55
Editorial Board	55
The functional roles of m6A modification in T lymphocyte responses and autoimmune diseases	55
ORF8a as a viroporin in SARS-CoV-2 infection?	54
Editorial Board	54
Editorial Board	54
The conundrum of current anti-SARS-CoV-2 vaccines	53
Macrophage migration inhibitor factor (MIF): Potential role in cognitive impairment disorders	51
Response to: Letter to the Editor on “Bonafè M, Prattichizzo F, Giuliani A, Storci G, Sabbatinelli J, Olivieri F. Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcom	50
Serum amyloid A and inflammasome activation: A link to breast cancer progression?	47
COVID-19 as a mediator of interferon deficiency and hyperinflammation: Rationale for the use of JAK1/2 inhibitors in combination with interferon	46
Cytokine signalling in formation of neutrophil extracellular traps: Implications for health and diseases	45
LC3B: A microtubule-associated protein influences disease progression and prognosis	44
Role of SARS-CoV-2 -induced cytokines and growth factors in coagulopathy and thromboembolism	43

Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics	43
Potential effects of HMGB1 on viral replication and virus infection-induced inflammatory responses: A promising therapeutic target for virus infection-induced inflammatory diseases	42
Influence of adipose tissue immune dysfunction on childhood obesity	42
Neurotrophic factors and their receptors in lung development and implications in lung diseases	40
COVID-19 and dys-regulation of pulmonary endothelium: implications for vascular remodeling	40
Retard or exacerbate: Role of long non-coding RNA growth arrest-specific 5 in the fibrosis	39
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells	38
T cell receptor signaling in the differentiation and plasticity of CD4+ T cells	38
Role of the Wnt and GTPase pathways in breast cancer tumorigenesis and treatment	36
MDSCs might be “Achilles heel” for eradicating CSCs	35
Unveiling cytokine charge disparity as a potential mechanism for immune regulation	34
Targeting PD-1/PD-L1 in tumor immunotherapy: Mechanisms and interactions with host growth regulatory pathways	33
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions	32
Crosstalk between glucose metabolism, lactate production and immune response modulation	32
Antiphospholipid antibodies and risk of post-COVID-19 vaccination thrombophilia: The straw that breaks the camel's back?	31
Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia	31
Role of circular RNA in myocardial ischemia and ageing-related diseases	31
FGF/FGFR signaling: From lung development to respiratory diseases	30
Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic	30
The cytokine interleukin-11 crucially links bone formation, remodeling and resorption	30
Harnessing the potential of CD40 agonism in cancer therapy	28
GLP-1R agonist therapy and vaccine response: Neglected implications	27
COVID-19: From emerging variants to vaccination	26
Exosomes as a modulator of immune resistance in human cancers	26
The activin-follistatin system: Key regulator of kidney development, regeneration, inflammation, and fibrosis	26
The role of transforming growth factor β in cervical carcinogenesis	25
The Immunopathogenesis of a Cytokine Storm: The Key Mechanisms Underlying Severe COVID-19	25
Impact of chronic stress on intestinal mucosal immunity in colorectal cancer progression	25
Apoptotic cell-derived metabolites in efferocytosis-mediated resolution of inflammation	24
The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies	23
Role of the APRIL molecule in solid tumors	23
Pharmacological therapies and drug development targeting SARS-CoV-2 infection	23
Type I IFN-dependent antibody response at the basis of sex dimorphism in the outcome of COVID-19	22
Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy	22
Inflamm-ageing: How cytokines and nutrition shape the trajectory of ageing	21
Targeting NKG2D/NKG2DL axis in multiple myeloma therapy	21
NLRP1 inflammasome in neurodegenerative disorders: From pathology to therapies	21
A quartet of cancer stem cell niches in hepatocellular carcinoma	21
Interleukin-26 in host defense and inflammatory disorders of the airways	20
Editorial Board	20
Editorial Board	20
Editorial Board	19
Editorial Board	19
Editorial Board	18
Editorial Board	18
B cell-activating factor and its targeted therapy in autoimmune diseases	18
Editorial Board	18
Netrin-1: An emerging player in inflammatory diseases	17
Revisiting IRF1-mediated antiviral innate immunity	17
Small extracellular vesicle-mediated bidirectional crosstalk between neutrophils and tumor cells	16

Hallmarks of aging and immunosenescence: Connecting the dots	16
The IFN-γ/miniTrpRS signaling axis: An insight into the pathophysiology of osteoporosis and therapeutic potential	16
From orphan to oncogene: The role of GPR35 in cancer and immune modulation	16
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands	16
Radiation-targeted immunotherapy: A new perspective in cancer radiotherapy	16
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	15
Semaphorins in health and disease	15
Role of gremlin-1 in the pathophysiology of the adipose tissues	15
Extracellular vesicles in cancer: Shaping the intricate network of metabolic reprogramming and immune interactions in the tumor microenvironment	14
Exosome-mediated metabolic reprogramming: Implications in esophageal carcinoma progression and tumor microenvironment remodeling	14
Secretory Leukocyte Protease Inhibitor (SLPI) in mucosal tissues: Protects against inflammation, but promotes cancer	13
Receptor binding competition: A paradigm for regulating TGF-β family action	13
SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities	13
Role of lipid signalling in extracellular vesicles-mediated cell-to-cell communication	13
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects	13
Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury	13
Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy	12
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases	12
Interferon-I modulation and natural products: Unraveling mechanisms and therapeutic potential in severe COVID-19	12
Decoding the roles of heat shock proteins in liver cancer	12
The impact of cytokines in neuroinflammation-mediated stroke	11
Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism	11
Cytokines on the way to secretion	11
Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases	11
Snake venom vascular endothelial growth factors (svVEGFs): Unravelling their molecular structure, functions, and research potential	10
Exercise tolls the bell for key mediators of low-grade inflammation in dysmetabolic conditions	10
Cytokine modulation and immunoregulation of uterine NK cells in pregnancy disorders	10
Assessment of clinical studies evaluating combinations of immune checkpoint inhibitors with locoregional treatments in solid tumors	10
Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron	10
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy	10
Genetically modified immunomodulatory cell-based biomaterials in tissue regeneration and engineering	9
Editorial Board	9
S100A8/A9 in COVID-19 pathogenesis: Impact on clinical outcomes	9
Chemokine networks modulating natural killer cell trafficking to solid tumors	9
Editorial Board	9
Biological functions of NLRP3 inflammasome: A therapeutic target in inflammatory bowel disease	9
Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions	9
Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity	9
The interleukin-1 cytokine family members: Role in cancer pathogenesis and potential therapeutic applications in cancer immunotherapy	9
Anticancer innovative therapy congress: Highlights from the 10th anniversary edition	8
Fibrinogen-like protein 2: Its biological function across cell types and the potential to serve as an immunotherapy target for brain tumors	8
Growth differentiation factor-15 and its role in diabetes and cardiovascular disease	8
Advances in extracellular vesicles as mediators of cell-to-cell communication in pregnancy	8
Interferons and other cytokines, genetics and beyond in COVID-19 and autoimmunity	8
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances	8
Signaling crosstalk between mesenchymal stem cells and tumor cells: Implications for tumor suppression or progression	8
Clinical progress in MSC-based therapies for the management of severe COVID-19	8
AntagomiRs: A novel therapeutic strategy for challenging COVID-19 cytokine storm	7
Cytokine storm with rapidly elevated interleukin-6 indicates sudden death in patients with critical COVID-19	7
The Coronavirus pandemic – 2022: Viruses, variants & vaccines	7
Molecular regulation of autophagy in a pro-inflammatory tumour microenvironment: New insight into the role of serum amyloid A	7
Participation of interferons in psoriatic inflammation	7
Unravelling the immunobiology of innate lymphoid cells (ILCs): Implications in health and disease	7
Before the “cytokine storm”: Boosting efferocytosis as an effective strategy against SARS-CoV-2 infection and associated complications	7
Editorial Board	7
The determinant role of IL-6 in the establishment of inflammation leading to spontaneous preterm birth	6
Biomarker discovery in hepatocellular carcinoma (HCC) for personalized treatment and enhanced prognosis	6
IL-33 in cancer immunotherapy: Pleiotropic functions and biological strategies	6
The involvement of TH17 cells in the pathogenesis of IBD	6
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights	6
Distinct roles of MIF in the pathogenesis of ischemic heart disease	6
The intersection of microbiome and autoimmunity in long COVID-19: Current insights and future directions	6
Erratum to “Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2” [Cytokine Growth Factor Rev. 66 (2022) 26–37]	6
The impact of adipokines on vascular networks in adipose tissue	6
Correlation between PD-1/PD-L1 expression and polarization in tumor-associated macrophages: A key player in tumor immunotherapy	6
Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy	6
Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs	6
SARS-CoV-2 Mutations and their Viral Variants	6
Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus	6
Corrigendum to “Dually modified transmembrane proteoglycans in development and disease” [Cytokine Growth Factor Rev. 39 (2018) 124–136]	6