OOIR: Observatory of International Research

Papers

(The median citation count of Cytokine & Growth Factor Reviews is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Editorial Board	287
Corrigendum to “Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy” [Cytokine Growth Factor Rev. 84 (2025) 59–73]	157
Unveiling cytokine charge disparity as a potential mechanism for immune regulation	151
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs	140
COVID-19: From emerging variants to vaccination	138
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions	128
Editorial Board	125
Editorial Board	103
Editorial Board	93
Erratum to “TLR-Based therapeutic strategies for Hepatocellular carcinoma” [Cytokine Growth Factor Rev. Volume 85 2025 Pages 179–189]	91
Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism	88
Metabolic Regulation of cGAS-STING Signaling in the Tumor Microenvironment: Dual Immune Roles and Therapeutic Implications	87
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy	85
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects	80
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances	77
Targeting cytokines: Reshaping the pancreatic tumor microenvironment	77
Editorial Board	68
Molecular mechanisms of regulation of IL-1 and its receptors	68
Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection	62
Natural killers or natural regulators? Dual roles of NK cells in checkpoint immunotherapy	59
Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration	59
The immunodynamics of pulmonary fibrosis	54
Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets	54
Cytokine symphony: Deciphering the tumor microenvironment and metastatic axis in oral cancer	54
Exogenous drug-induced mouse models of atopic dermatitis	53

Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation	53
TGF-β mediated drug resistance in solid cancer	52
Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis	50
Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis	50
Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2	47
The cGAS-STING pathway: Post-translational modifications and functional implications in diseases	47
Role of FOXO3 in regulation of redox homeostasis and promotion of red blood cell longevity in sickle cell disease	47
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells	47
Exosomes as a modulator of immune resistance in human cancers	46
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	46
Decoding the roles of heat shock proteins in liver cancer	45
Multifaceted role of CD14 in innate immunity and tissue homeostasis	45
Editorial Board	44
Post COVID-19 pandemic Inflammatory Insights into Cancer: Consequences for immunotherapy	43
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	42
The role of neurotransmitter signaling in colorectal cancer progression: Opportunities for drug repurposing	42
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases	42
Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression	41
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands	41
Forgetting COVID-19 – Introduction to the special issue	40
Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies	40
From senescence to scarring: Exploring TGF-β signaling in cellular aging, fibrotic remodeling, and pulmonary fibrosis	39
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights	39
The impact of adipokines on vascular networks in adipose tissue	39
Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities	37
Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation	35
Fibroblast growth factor homologous factors in neural signaling: Molecular mechanisms and disease-relevant dysregulation	34
Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer	34
The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance	34
Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism	33
mTOR in programmed cell death and its therapeutic implications	33
Cholecystokinin and gastrin as immune modulating hormones: Implications and applications	32
Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy	32
Glioblastoma-associated macrophages: A key target in overcoming glioblastoma therapeutic resistance	32
Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders	32
Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression	32
Nefarious NTRK oncogenic fusions in pediatric sarcomas: Too many to Trk	32
Therapeutic inhibition of the JAK-STAT pathway in the treatment of inflammatory bowel disease	32
Could IL-25 be a potential therapeutic target for intestinal inflammatory diseases?	30
Uncovering key mechanisms and intervention therapies in aging skin	30
Spatiotemporal dynamic regulation of the CX3CL1-CX3CR1 axis: A double-edged sword in the tumor immune microenvironment and new strategies for precision therapy	30
cPLA2 in musculoskeletal and autoimmune diseases: Molecular mechanisms and therapeutic insights	29
The intricate relationship between cytokines and galectins in immune modulation	29
The journey of STING: Guiding immune signaling through membrane trafficking	28
The IL-2A receptor pathway and its role in lymphocyte differentiation and function	28
Alternative pathways driven by STING: From innate immunity to lipid metabolism	28
Regulation of regulated cell death by extracellular vesicles in acute kidney injury and chronic kidney disease	28
The critical role of osteopontin (OPN) in fibrotic diseases	27
JAK inhibitors in immune regulation and treatment of vitiligo	26
Unraveling the intricacies of neutrophil extracellular traps in inflammatory bowel disease: Pathways, biomarkers, and promising therapies	26

Mechanisms and routes of G-protein coupled receptor-mediated Tau degradation in Alzheimer’s disease	26
Editorial Board	25
Cancer-associated fibroblasts: Vital suppressors of the immune response in the tumor microenvironment	25
Multiple post-translational modifications ensure EGFR functionality: Potential therapeutic targets to overcome its drug-resistance mutations	25
Leptin as a mechanistic link between obesity and systemic lupus erythematous	24
Retard or exacerbate: Role of long non-coding RNA growth arrest-specific 5 in the fibrosis	24
Decoding the neuroimmune axis in colorectal cancer: From neural circuitry to therapeutic innovation	23
The activin-follistatin system: Key regulator of kidney development, regeneration, inflammation, and fibrosis	23
LC3B: A microtubule-associated protein influences disease progression and prognosis	23
An emerging paradigm of CXCL16 involvement in cancer progression	23
Endothelial and macrophage interactions in the angiogenic niche	23
The anti-inflammatory effects of itaconate and its derivatives in neurological disorders	23
T cell receptor signaling in the differentiation and plasticity of CD4+ T cells	23
Macrophage migration inhibitor factor (MIF): Potential role in cognitive impairment disorders	22
GLP-1R agonist therapy and vaccine response: Neglected implications	22
Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy	21
Role of lipid signalling in extracellular vesicles-mediated cell-to-cell communication	21
Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases	21
Bacterial immunomodulatory structures as determinants of the maternal immune response and autism risk	19
Pharmacological therapies and drug development targeting SARS-CoV-2 infection	19
Role of cytokine-based immunotherapy approaches in gastrointestinal cancers	19
Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron	18
Tightly bound T-cell clusters: A new class of hyper-effector tumor killers	18
Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury	18
Exosome-mediated metabolic reprogramming: Implications in esophageal carcinoma progression and tumor microenvironment remodeling	18
Pancreatic cancer exosomes: Their role in drug resistance and immunomodulation	17
The impact of cytokines in neuroinflammation-mediated stroke	17
Cytokines on the way to secretion	17
GDF15 in the tumor microenvironment: A central mediator of cancer immunometabolism and therapeutic resistance	16
Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs	16
Assessment of clinical studies evaluating combinations of immune checkpoint inhibitors with locoregional treatments in solid tumors	16
The involvement of TH17 cells in the pathogenesis of IBD	16
Meteorin-like/Metrnl: A pleiotropic cytokine implicated in metabolic, inflammatory and malignant disorders	16
The central role of CXCL10-CXCR3 signaling in neuroinflammation and neuropathology	16
The role of microglial activation on ischemic stroke: Modulation by fibroblast growth factors	16
Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus	16
Role of growth factors and their interplay during oligodendroglial differentiation and maturation	16
Editorial Board	15
Chemokines in thyroid cancer: Mechanistic insights and clinical implications	14
Targeting interleukin-17 in radiation-induced toxicity and cancer progression	14
TLR-based therapeutic strategies for hepatocellular carcinoma	14
Neuroprotective properties of ciliary neurotrophic factor in the retina for the treatment of macular telangiectasia type 2	14
The IL-17 axis in gastric carcinogenesis: From inflammation to oncogenic transformation	13
BCR-ABL: The molecular mastermind behind chronic myeloid leukemia	13
The odyssey of cGAS: From cytosol to nucleus	13
Inflammation and Type 1 interferon signaling in pancreatic adenocarcinoma: Insights into inflammasome driven crosstalk and therapeutic advances	13
Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors	13
Mitochondrial DNA-mediated cGAS–STING activation and its crosstalk with NLRP3 inflammasome in chronic obstructive pulmonary disease	13
Granulocyte macrophage colony stimulating factor in virus-host interactions and its implication for immunotherapy	13
Preexisting immunity: Barrier or bridge to effective oncolytic virus therapy?	13
Unveiling the role of IL-17: Therapeutic insights and cardiovascular implications	13
Cardiac and pericardial inflammatory changes and post-cardiac surgery atrial fibrillation	12
Protein-protein interactions and related inhibitors involved in the NLRP3 inflammasome pathway	12
Adeno-associated virus therapies: Pioneering solutions for human genetic diseases	12
The evolving epidemiology of monkeypox virus	12
Extracellular vesicles in cardiovascular diseases: From pathophysiology to diagnosis and therapy	12
The cytokine trio - visfatin, placental growth factor and fractalkine – and their role in myocardial infarction with non-obstructive coronary arteries (MINOCA)	12
Neuro-endocrine-immune regulation of metabolic homeostasis	12
Acinar cells and the development of pancreatic fibrosis	12