OOIR: Observatory of International Research

Papers

(The median citation count of Cytokine & Growth Factor Reviews is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
SARS-CoV-2 Mutations and their Viral Variants	120
The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies	103
The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved	92
Crosstalk between glucose metabolism, lactate production and immune response modulation	90
Hallmarks of aging and immunosenescence: Connecting the dots	86
SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders	84
Applications of the regenerative capacity of platelets in modern medicine	74
Mechanisms of NLRP3 priming in inflammaging and age related diseases	73
Correlation between PD-1/PD-L1 expression and polarization in tumor-associated macrophages: A key player in tumor immunotherapy	64
Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?	59
Semaphorins in health and disease	54
Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy	53
Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia	53
SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities	50
Receptor binding competition: A paradigm for regulating TGF-β family action	50
S100A8/A9 in COVID-19 pathogenesis: Impact on clinical outcomes	48
The involvement of TH17 cells in the pathogenesis of IBD	48
ALCAM/CD166: A pleiotropic mediator of cell adhesion, stemness and cancer progression	48
FGF/FGFR signaling: From lung development to respiratory diseases	48
Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2	47
Growth differentiation factor-15 and its role in diabetes and cardiovascular disease	47
Chemokine networks modulating natural killer cell trafficking to solid tumors	46
The evolving epidemiology of monkeypox virus	45
Recent advances in the treatment of IBD: Targets, mechanisms and related therapies	45
SARS-CoV-2: Targeted managements and vaccine development	44

Secretory Leukocyte Protease Inhibitor (SLPI) in mucosal tissues: Protects against inflammation, but promotes cancer	43
The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system	42
Cytokines in oncolytic virotherapy	41
Engineering and combining oncolytic measles virus for cancer therapy	40
Antiphospholipid antibodies and risk of post-COVID-19 vaccination thrombophilia: The straw that breaks the camel's back?	40
Biological functions of NLRP3 inflammasome: A therapeutic target in inflammatory bowel disease	40
Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy	39
Biological functions and therapeutic opportunities of soluble cytokine receptors	39
IL-36 in chronic inflammation and cancer	38
An evaluation of the effects of probiotics on tumoral necrosis factor (TNF-α) signaling and gene expression	38
The determinant role of IL-6 in the establishment of inflammation leading to spontaneous preterm birth	38
The immunosuppressive and pro-tumor functions of CCL18 at the tumor microenvironment	36
Revisiting IRF1-mediated antiviral innate immunity	36
Selective inhibition of Tumor necrosis factor receptor-1 (TNFR1) for the treatment of autoimmune diseases	35
Pro-angiogenic activity and vasculogenic mimicry in the tumor microenvironment by leptin in cancer	35
Mechanisms of measles virus oncolytic immunotherapy	35
Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence	34
Cancer-associated fibroblasts: Vital suppressors of the immune response in the tumor microenvironment	34
The Coronavirus pandemic – 2022: Viruses, variants & vaccines	32
Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic	32
Exercise tolls the bell for key mediators of low-grade inflammation in dysmetabolic conditions	32
MDSCs in sepsis-induced immunosuppression and its potential therapeutic targets	31
Galectins as modulators of receptor tyrosine kinases signaling in health and disease	31
Principles of the activin receptor signaling pathway and its inhibition	30
Role of SARS-CoV-2 -induced cytokines and growth factors in coagulopathy and thromboembolism	29
The interleukin-1 cytokine family members: Role in cancer pathogenesis and potential therapeutic applications in cancer immunotherapy	28
Development of mRNA vaccines against respiratory syncytial virus (RSV)	28
The cytokine interleukin-11 crucially links bone formation, remodeling and resorption	27
Pathogenic mechanisms of glucocorticoid-induced osteoporosis	27
Multifactorial effects of hyperglycaemia, hyperinsulinemia and inflammation on bone remodelling in type 2 diabetes mellitus	26
Small extracellular vesicle-mediated bidirectional crosstalk between neutrophils and tumor cells	26
Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer	26
Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron	25
Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics	24
The IL-2A receptor pathway and its role in lymphocyte differentiation and function	23
Covid-19 in Brazil: A sad scenario	23
IL-6 and its role in IgA nephropathy development	22
Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions	22
Chagas disease: Immunology of the disease at a glance	22
The two-faces of NK cells in oncolytic virotherapy	22
Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity	21
Netrin-1: An emerging player in inflammatory diseases	21
The pros and cons of interferons for oncolytic virotherapy	21
COVID-19 as a mediator of interferon deficiency and hyperinflammation: Rationale for the use of JAK1/2 inhibitors in combination with interferon	21
Mesenchymal stromal cells to fight SARS-CoV-2: Taking advantage of a pleiotropic therapy	20
The pathogenic importance of CCL21 and CCR7 in rheumatoid arthritis	20
Potential effects of HMGB1 on viral replication and virus infection-induced inflammatory responses: A promising therapeutic target for virus infection-induced inflammatory diseases	20
When Rab GTPases meet innate immune signaling pathways	20
Cytokine storm with rapidly elevated interleukin-6 indicates sudden death in patients with critical COVID-19	19
Predictive monitoring and therapeutic immune biomarkers in the management of clinical complications of COVID-19	19

Interferon, restriction factors and SUMO pathways	19
Serum amyloid A and inflammasome activation: A link to breast cancer progression?	18
Snake venom vascular endothelial growth factors (svVEGFs): Unravelling their molecular structure, functions, and research potential	18
B cell-activating factor and its targeted therapy in autoimmune diseases	18
Revisiting PD-1/PD-L pathway in T and B cell response: Beyond immunosuppression	18
The NOTCH4-GATA4-IRG1 axis as a novel target in early-onset colorectal cancer	17
Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection	17
Current utilization of interferon alpha for the treatment of coronavirus disease 2019: A comprehensive review	16
Type I IFN-dependent antibody response at the basis of sex dimorphism in the outcome of COVID-19	16
Preexisting immunity: Barrier or bridge to effective oncolytic virus therapy?	16
Roles of the gut microbiota in severe SARS-CoV-2 infection	16
Role of lipid signalling in extracellular vesicles-mediated cell-to-cell communication	16
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	16
Tumour vasculature: Friend or foe of oncolytic viruses?	15
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	15
Latest developments in tryptophan metabolism: Understanding its role in B cell immunity	15
T cell receptor signaling in the differentiation and plasticity of CD4+ T cells	15
Balancing STING in antimicrobial defense and autoinflammation	15
Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression	14
Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus	14
mTOR in programmed cell death and its therapeutic implications	14
Interferon regulatory factor 8 governs myeloid cell development	14
TGF-β mediated drug resistance in solid cancer	14
Clinical progress in MSC-based therapies for the management of severe COVID-19	14
Developing oncolytic viruses for clinical use: A consortium approach	14
The role and transformative potential of IL-19 in atherosclerosis	13
Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms	13
The multiple functions of the co-chaperone stress inducible protein 1	13
Role of circular RNA in myocardial ischemia and ageing-related diseases	13
Cancer and Covid-19: Collectively catastrophic	13
Extracellular vesicles as a novel mediator of interkingdom communication	12
Role of the APRIL molecule in solid tumors	12
Type I and III IFN-mediated antiviral actions counteracted by SARS-CoV-2 proteins and host inherited factors	12
Role of the Wnt and GTPase pathways in breast cancer tumorigenesis and treatment	12
AntagomiRs: A novel therapeutic strategy for challenging COVID-19 cytokine storm	12
Oncolytic Immunotherapy: Can’t Start a Fire Without a Spark	12
The impact of adipokines on vascular networks in adipose tissue	11
Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis	11
Before the “cytokine storm”: Boosting efferocytosis as an effective strategy against SARS-CoV-2 infection and associated complications	11
The roles and potential therapeutic implications of C5a in the pathogenesis of COVID-19-associated coagulopathy	11
Role of TGF-β signaling in the mechanisms of tamoxifen resistance	10
The IFN-γ/miniTrpRS signaling axis: An insight into the pathophysiology of osteoporosis and therapeutic potential	10
Role of cellular senescence in inflammatory lung diseases	10
Multiple post-translational modifications ensure EGFR functionality: Potential therapeutic targets to overcome its drug-resistance mutations	10
Molecular regulation of autophagy in a pro-inflammatory tumour microenvironment: New insight into the role of serum amyloid A	10
Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation	9
Apoptotic cell-derived metabolites in efferocytosis-mediated resolution of inflammation	9
Old drugs, new tricks: Emerging role of drug repurposing in the management of atopic dermatitis	9
Acinar cells and the development of pancreatic fibrosis	9
Exploiting natural antiviral immunity for the control of pandemics: Lessons from Covid-19	9
Interleukin-26 in host defense and inflammatory disorders of the airways	9
The functional roles of m6A modification in T lymphocyte responses and autoimmune diseases	9
The cGAS-STING pathway: Post-translational modifications and functional implications in diseases	9
Participation of interferons in psoriatic inflammation	9
MDSCs might be “Achilles heel” for eradicating CSCs	9
The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance	8
Response to: Letter to the Editor on “Bonafè M, Prattichizzo F, Giuliani A, Storci G, Sabbatinelli J, Olivieri F. Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcom	8
Motor rehabilitation as a therapeutic tool for spinal cord injury: New perspectives in immunomodulation	8
Plasticity in T-cell mitochondrial metabolism: A necessary peacekeeper during the troubled times of persistent HIV-1 infection	8
Nefarious NTRK oncogenic fusions in pediatric sarcomas: Too many to Trk	8
Fibrinogen-like protein 2: Its biological function across cell types and the potential to serve as an immunotherapy target for brain tumors	8