OOIR: Observatory of International Research

Papers

(The median citation count of Cytokine & Growth Factor Reviews is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Editorial Board	265
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs	144
Corrigendum to “Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy” [Cytokine Growth Factor Rev. 84 (2025) 59–73]	142
COVID-19: From emerging variants to vaccination	129
Unveiling cytokine charge disparity as a potential mechanism for immune regulation	123
Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions	116
Editorial Board	115
Editorial Board	87
Erratum to “TLR-Based therapeutic strategies for Hepatocellular carcinoma” [Cytokine Growth Factor Rev. Volume 85 2025 Pages 179–189]	82
Editorial Board	82
Proteomics analysis of circulating small extracellular vesicles: Focus on the contribution of EVs to tumor metabolism	80
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: Biological and clinical aspects	73
Metabolic Regulation of cGAS-STING Signaling in the Tumor Microenvironment: Dual Immune Roles and Therapeutic Implications	72
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy	72
Targeting cytokines: Reshaping the pancreatic tumor microenvironment	68
Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances	63
Molecular mechanisms of regulation of IL-1 and its receptors	61
Natural killers or natural regulators? Dual roles of NK cells in checkpoint immunotherapy	58
Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration	53
Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection	48
Cytokine symphony: Deciphering the tumor microenvironment and metastatic axis in oral cancer	47
Exogenous drug-induced mouse models of atopic dermatitis	47
TGF-β mediated drug resistance in solid cancer	45
Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets	45
Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis	43

Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2	43
Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation	43
Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?	42
Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis	42
The cGAS-STING pathway: Post-translational modifications and functional implications in diseases	42
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells	40
Exosomes as a modulator of immune resistance in human cancers	40
MDSCs might be “Achilles heel” for eradicating CSCs	40
Multifaceted role of CD14 in innate immunity and tissue homeostasis	40
The roles of cell-cell and organ-organ crosstalk in the type 2 diabetes mellitus associated inflammatory microenvironment	39
Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression	39
Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies	39
Editorial Board	38
Modulation of IL-33/ST2 signaling as a potential new therapeutic target for cardiovascular diseases	38
Decoding the roles of heat shock proteins in liver cancer	38
The role of neurotransmitter signaling in colorectal cancer progression: Opportunities for drug repurposing	37
Post COVID-19 pandemic Inflammatory Insights into Cancer: Consequences for immunotherapy	37
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands	37
Forgetting COVID-19 – Introduction to the special issue	36
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights	35
From senescence to scarring: Exploring TGF-β signaling in cellular aging, fibrotic remodeling, and pulmonary fibrosis	35
The impact of adipokines on vascular networks in adipose tissue	34
Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities	34
Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer	32
Therapeutic inhibition of the JAK-STAT pathway in the treatment of inflammatory bowel disease	31
Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism	31
Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation	31
The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance	31
Nefarious NTRK oncogenic fusions in pediatric sarcomas: Too many to Trk	30
Glioblastoma-associated macrophages: A key target in overcoming glioblastoma therapeutic resistance	30
Spatiotemporal dynamic regulation of the CX3CL1-CX3CR1 axis: A double-edged sword in the tumor immune microenvironment and new strategies for precision therapy	30
mTOR in programmed cell death and its therapeutic implications	30
Cholecystokinin and gastrin as immune modulating hormones: Implications and applications	28
Editorial Board	28
Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders	27
Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression	27
Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy	26
Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer	26
Unraveling the intricacies of neutrophil extracellular traps in inflammatory bowel disease: Pathways, biomarkers, and promising therapies	26
Could IL-25 be a potential therapeutic target for intestinal inflammatory diseases?	26
Uncovering key mechanisms and intervention therapies in aging skin	25
JAK inhibitors in immune regulation and treatment of vitiligo	25
Multiple post-translational modifications ensure EGFR functionality: Potential therapeutic targets to overcome its drug-resistance mutations	25
cPLA2 in musculoskeletal and autoimmune diseases: Molecular mechanisms and therapeutic insights	25
The intricate relationship between cytokines and galectins in immune modulation	24
The IL-2A receptor pathway and its role in lymphocyte differentiation and function	24
Alternative pathways driven by STING: From innate immunity to lipid metabolism	24
Mechanisms and routes of G-protein coupled receptor-mediated Tau degradation in Alzheimer’s disease	24
The journey of STING: Guiding immune signaling through membrane trafficking	23
Cancer-associated fibroblasts: Vital suppressors of the immune response in the tumor microenvironment	23

The critical role of osteopontin (OPN) in fibrotic diseases	23
Editorial Board	23
Regulation of regulated cell death by extracellular vesicles in acute kidney injury and chronic kidney disease	23
Retard or exacerbate: Role of long non-coding RNA growth arrest-specific 5 in the fibrosis	22
Leptin as a mechanistic link between obesity and systemic lupus erythematous	22
Macrophage migration inhibitor factor (MIF): Potential role in cognitive impairment disorders	21
The anti-inflammatory effects of itaconate and its derivatives in neurological disorders	21
The functional roles of m6A modification in T lymphocyte responses and autoimmune diseases	21
Decoding the neuroimmune axis in colorectal cancer: From neural circuitry to therapeutic innovation	20
GLP-1R agonist therapy and vaccine response: Neglected implications	20
T cell receptor signaling in the differentiation and plasticity of CD4+ T cells	20
The activin-follistatin system: Key regulator of kidney development, regeneration, inflammation, and fibrosis	19
LC3B: A microtubule-associated protein influences disease progression and prognosis	18
Endothelial and macrophage interactions in the angiogenic niche	18
Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy	18
An emerging paradigm of CXCL16 involvement in cancer progression	18
Bacterial immunomodulatory structures as determinants of the maternal immune response and autism risk	18
The central role of CXCL10-CXCR3 signaling in neuroinflammation and neuropathology	16
Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury	16
Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron	16
Pancreatic cancer exosomes: Their role in drug resistance and immunomodulation	16
Cytokines on the way to secretion	16
Role of cytokine-based immunotherapy approaches in gastrointestinal cancers	15
Tightly bound T-cell clusters: A new class of hyper-effector tumor killers	15
Pharmacological therapies and drug development targeting SARS-CoV-2 infection	15
Exosome-mediated metabolic reprogramming: Implications in esophageal carcinoma progression and tumor microenvironment remodeling	15
The impact of cytokines in neuroinflammation-mediated stroke	14
Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases	14
Role of lipid signalling in extracellular vesicles-mediated cell-to-cell communication	14
The involvement of TH17 cells in the pathogenesis of IBD	13
Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs	13
Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus	13
Meteorin-like/Metrnl: A pleiotropic cytokine implicated in metabolic, inflammatory and malignant disorders	13
Role of growth factors and their interplay during oligodendroglial differentiation and maturation	13
GDF15 in the tumor microenvironment: A central mediator of cancer immunometabolism and therapeutic resistance	13
Targeting interleukin-17 in radiation-induced toxicity and cancer progression	12
TLR-based therapeutic strategies for hepatocellular carcinoma	12
Editorial Board	12
Preexisting immunity: Barrier or bridge to effective oncolytic virus therapy?	12
Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors	12
Unveiling the role of IL-17: Therapeutic insights and cardiovascular implications	12
Assessment of clinical studies evaluating combinations of immune checkpoint inhibitors with locoregional treatments in solid tumors	12
The role of microglial activation on ischemic stroke: Modulation by fibroblast growth factors	12
Inflammation and Type 1 interferon signaling in pancreatic adenocarcinoma: Insights into inflammasome driven crosstalk and therapeutic advances	11
The odyssey of cGAS: From cytosol to nucleus	11
Neuroprotective properties of ciliary neurotrophic factor in the retina for the treatment of macular telangiectasia type 2	11
BCR-ABL: The molecular mastermind behind chronic myeloid leukemia	11
Neuro-endocrine-immune regulation of metabolic homeostasis	10
Granulocyte macrophage colony stimulating factor in virus-host interactions and its implication for immunotherapy	10
Protein-protein interactions and related inhibitors involved in the NLRP3 inflammasome pathway	10
Cardiac and pericardial inflammatory changes and post-cardiac surgery atrial fibrillation	10
Nanotechnology-based cytokine delivery strategies in gastrointestinal cancers	10
Acinar cells and the development of pancreatic fibrosis	10
The evolving epidemiology of monkeypox virus	10
The IL-17 axis in gastric carcinogenesis: From inflammation to oncogenic transformation	10
The cytokine trio - visfatin, placental growth factor and fractalkine – and their role in myocardial infarction with non-obstructive coronary arteries (MINOCA)	10
Extracellular vesicles in cardiovascular diseases: From pathophysiology to diagnosis and therapy	10